prednisolone has been researched along with Hypertension, Pulmonary in 43 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Excerpt | Relevance | Reference |
---|---|---|
"A 57-year-old woman with Crow-Fukase syndrome presented thiamine deficiency and pulmonary hypertension of unknown etiology." | 7.69 | Thiamine deficiency and pulmonary hypertension in Crow-Fukase syndrome. ( Gohma, I; Hatta, K; Imanaka, T; Okura, H, 1995) |
"The pathogenesis of monocrotaline-induced pulmonary hypertension is not clear." | 7.67 | Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. ( Kanisawa, M; Kato, T; Kitamura, H, 1989) |
" According to the possibility of either idiopathic pulmonary fibrosis or chronic hypersensitivity pneumonitis, treatment included prednisolone, azathioprine, acetylcysteine and avoidance of contact with the parakeet, but there was an unfavorable response and the patient was subsequently referred for lung transplant." | 3.79 | Clinical case: Differential diagnosis of idiopathic pulmonary fibrosis. ( Alfaro, TM; Cordeiro, CR; Freitas, S, 2013) |
"A rare case of childhood pulmonary haemosiderosis with juvenile idiopathic arthritis is discussed, with particular reference to treatment with hydroxychloroquine and sildenafil for pulmonary hypertension which occurs secondary to this disease." | 3.74 | Pulmonary haemosiderosis with juvenile idiopathic arthritis in a Malaysian child. ( Noor, AS; Quah, BS; Rasool, AH; Roberton, D; Wong, AR, 2007) |
"A 57-year-old woman with Crow-Fukase syndrome presented thiamine deficiency and pulmonary hypertension of unknown etiology." | 3.69 | Thiamine deficiency and pulmonary hypertension in Crow-Fukase syndrome. ( Gohma, I; Hatta, K; Imanaka, T; Okura, H, 1995) |
"The pathogenesis of monocrotaline-induced pulmonary hypertension is not clear." | 3.67 | Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. ( Kanisawa, M; Kato, T; Kitamura, H, 1989) |
"To investigate the involvement of the immune mechanism in the development of pulmonary hypertension in rats given monocrotaline, pulmonary hypertension was induced in rats and the effect of daily injection of prednisolone was studied." | 3.66 | Experimental study on monocrotaline induced pulmonary hypertensive rats. (1) Effect of long-term injection of immunosuppressant. ( Furuya, H; Goto, Y; Hata, J; Kanemoto, N; Tanabe, T, 1981) |
" Methylprednisolone pulse therapy was performed in patients resistant to the high dosage of PSL." | 2.47 | The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases: report of five cases and a literature review. ( Atsumi, T; Fujieda, Y; Horita, T; Kataoka, H; Kato, M; Koike, T; Nishimura, M; Odani, T; Ohira, H; Oku, K; Otomo, K; Tsujino, I; Yasuda, S, 2011) |
"Fatigue is a frequent symptom of patients with sarcoidosis." | 1.40 | Factors associated with fatigue in sarcoidosis. ( Bosse-Henck, A; Brähler, E; Fleischer, M; Hinz, A; Wirtz, H, 2014) |
"Echocardiography detected left ventricular hypertrophy and diastolic dysfunction." | 1.39 | Pulmonary hypertension and refractory heart failure in a patient with Crow-Fukase (POEMS) syndrome. ( Hisa, S; Kanno, Y; Kobayashi, A; Mizukami, H; Nakazato, K; Noji, H; Ogawa, K; Ohkawara, H; Saitoh, S; Shichishima-Nakamura, A; Suzuki, H; Takahashi, H; Takeishi, Y; Yokokawa, T; Yoshihisa, A, 2013) |
"Combined idiopathic pulmonary fibrosis (IPF) with pulmonary emphysema (CPFE) is a syndrome with a characteristic presentation of upper lobe emphysema and lower lobe fibrosis." | 1.39 | Clinical case: Combined pulmonary fibrosis and emphysema with pulmonary hypertension--clinical management. ( Cottin, V, 2013) |
"We report a rare case of diffuse systemic sclerosis (SSc) evolving into diffuse SSc/systemic lupus erythematosus (SLE) overlap syndrome." | 1.38 | Juvenile diffuse systemic sclerosis/systemic lupus erythematosus overlap syndrome--a case report. ( Fu, LS; Lin, HK; Wang, JD, 2012) |
"Severe pulmonary hypertension is one of the fetal complications in various connective tissue diseases." | 1.32 | Severe pulmonary hypertension associated with primary Sjögren's syndrome. ( Ide, H; Kikuchi, K; Nakagawa, N; Nakano, H; Nishigaki, Y; Obata, H; Ohsaki, Y; Osanai, S; Takahashi, S; Tokusashi, Y, 2003) |
" The same symptoms subsequently recurred, and ESR and CRP levels increased proportionately to a decreased dosage of prednisolone." | 1.30 | [Chronic thromboembolic pulmonary hypertension associated with initial pulmonary involvement in Takayasu arteritis]. ( Kashiwabara, K; Kiguchi, T; Kishi, K; Kobayashi, K; Kusama, H; Matsuoka, T; Nakamura, H; Sarashina, G; Yagyu, H, 1998) |
"However, 4 patients with MCTD showed increased ACE levels (> 28." | 1.29 | Increased serum angiotensin I-converting enzyme activity in patients with mixed connective tissue disease and pulmonary hypertension. ( Arakawa, M; Honma, T; Kikuchi, M; Nakano, M; Ninomiya, Y; Ozawa, T; Sato, T, 1995) |
"Pulmonary hypertension was diagnosed in a patient with SLE after her 5th delivery." | 1.29 | Primary pulmonary hypertension in a patient with systemic lupus erythematosus: partial improvement with cyclophosphamide. ( Bootsma, H; Groen, H; Kallenberg, CG; Postma, DS, 1993) |
"In 1986, she was diagnosed as systemic lupus erythematosus (SLE)." | 1.28 | [A case of systemic lupus erythematosus complicated with pulmonary hypertension and massive pericardial effusion]. ( Akizuki, S; Irimajiri, S; Matsuoka, Y; Tsuji, S, 1991) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (13.95) | 18.7374 |
1990's | 10 (23.26) | 18.2507 |
2000's | 12 (27.91) | 29.6817 |
2010's | 15 (34.88) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Sugino, K | 1 |
Kabuki, T | 1 |
Shibuya, K | 1 |
Homma, S | 1 |
Yokokawa, T | 1 |
Nakazato, K | 1 |
Kanno, Y | 1 |
Mizukami, H | 1 |
Kobayashi, A | 1 |
Yoshihisa, A | 1 |
Takahashi, H | 1 |
Shichishima-Nakamura, A | 1 |
Ohkawara, H | 1 |
Noji, H | 1 |
Suzuki, H | 1 |
Saitoh, S | 1 |
Ogawa, K | 2 |
Hisa, S | 1 |
Takeishi, Y | 1 |
Cordeiro, CR | 1 |
Alfaro, TM | 1 |
Freitas, S | 1 |
Cottin, V | 1 |
Ishida, M | 2 |
Miyamura, T | 2 |
Kaieda, T | 1 |
Kimura, D | 2 |
Nakamura, A | 1 |
Takahama, S | 1 |
Kiyasu, J | 1 |
Minami, R | 1 |
Yamamoto, M | 1 |
Suematsu, E | 2 |
Fleischer, M | 1 |
Hinz, A | 1 |
Brähler, E | 1 |
Wirtz, H | 1 |
Bosse-Henck, A | 1 |
Sato, S | 1 |
Wong, AR | 1 |
Noor, AS | 1 |
Rasool, AH | 1 |
Quah, BS | 1 |
Roberton, D | 1 |
Hayashi, H | 1 |
Morimoto, K | 1 |
Matsuyama, M | 1 |
Kokuho, N | 1 |
Oota, K | 1 |
Masuko, H | 1 |
Iizuka, T | 1 |
Hayashihara, K | 1 |
Saito, T | 1 |
Kawabata, Y | 1 |
Taniguchi, Y | 1 |
Horino, T | 1 |
Kato, T | 2 |
Terada, Y | 1 |
Shimomura, Y | 1 |
Hara, M | 1 |
Mizote, I | 1 |
Nakaoka, Y | 1 |
Tanaka, H | 1 |
Asano, Y | 1 |
Sakata, Y | 1 |
Komuro, I | 1 |
Ogawa, A | 2 |
Nakamura, K | 2 |
Mizoguchi, H | 1 |
Fujii, N | 1 |
Fujio, H | 2 |
Kusano, KF | 2 |
Ohe, T | 2 |
Ito, H | 1 |
Naniwa, T | 1 |
Takeda, Y | 1 |
Lin, HK | 1 |
Wang, JD | 1 |
Fu, LS | 1 |
Ueda, Y | 1 |
Takahashi, Y | 1 |
Yamashita, H | 1 |
Kaneko, H | 1 |
Mimori, A | 1 |
Kato, M | 1 |
Kataoka, H | 1 |
Odani, T | 1 |
Fujieda, Y | 1 |
Otomo, K | 1 |
Oku, K | 1 |
Horita, T | 1 |
Yasuda, S | 1 |
Atsumi, T | 1 |
Ohira, H | 1 |
Tsujino, I | 1 |
Nishimura, M | 1 |
Koike, T | 1 |
Takagi, S | 1 |
Komatsu, N | 1 |
Mukerjee, D | 1 |
Kingdon, E | 1 |
Vanderpump, M | 1 |
Coghlan, JG | 1 |
HERBERG, D | 1 |
Kondo, H | 1 |
Nakagawa, N | 1 |
Osanai, S | 1 |
Ide, H | 1 |
Nishigaki, Y | 1 |
Takahashi, S | 1 |
Nakano, H | 1 |
Ohsaki, Y | 1 |
Kikuchi, K | 1 |
Tokusashi, Y | 1 |
Obata, H | 1 |
Endo, H | 1 |
Tanaka, S | 1 |
Sakai, M | 1 |
Matsubara, H | 1 |
Ikeda, T | 1 |
Kobayashi, K | 2 |
Miyazaki, I | 1 |
Asanuma, M | 1 |
Miyaji, K | 1 |
Miura, D | 1 |
Date, H | 1 |
Nagai, Y | 1 |
Yamanaka, M | 1 |
Nishimura, S | 1 |
Nakano, A | 1 |
Hasegawa, A | 1 |
Ishikawa, O | 1 |
Zhang, X | 1 |
Zeng, X | 1 |
Tanabe, T | 1 |
Furuya, H | 1 |
Kanemoto, N | 1 |
Goto, Y | 1 |
Hata, J | 1 |
Davies, J | 1 |
Nellen, M | 1 |
Goodwin, JF | 1 |
Okura, H | 1 |
Gohma, I | 1 |
Hatta, K | 1 |
Imanaka, T | 1 |
Ozawa, T | 2 |
Ninomiya, Y | 2 |
Honma, T | 2 |
Kikuchi, M | 2 |
Sato, T | 2 |
Nakano, M | 2 |
Arakawa, M | 2 |
Iwasaki, H | 1 |
Yoshida, H | 1 |
Takashima, F | 1 |
Shimizu, K | 1 |
Lee, JD | 1 |
Ueda, T | 1 |
Nakamura, T | 1 |
Groen, H | 1 |
Bootsma, H | 1 |
Postma, DS | 1 |
Kallenberg, CG | 1 |
Kasukawa, R | 1 |
Nishimaki, T | 1 |
Miyata, M | 1 |
Usui, K | 1 |
Anzai, C | 1 |
Sano, K | 1 |
Kumazaki, S | 1 |
Ishihara, T | 1 |
Kashiwabara, K | 1 |
Nakamura, H | 1 |
Sarashina, G | 1 |
Kishi, K | 1 |
Yagyu, H | 1 |
Kiguchi, T | 1 |
Kusama, H | 1 |
Matsuoka, T | 1 |
Bellotto, F | 1 |
Chiavacci, P | 1 |
Laveder, F | 1 |
Angelini, A | 1 |
Thiene, G | 1 |
Marcolongo, R | 1 |
Ooiwa, H | 1 |
Miyazawa, T | 1 |
Yamanishi, Y | 1 |
Hiyama, K | 1 |
Ishioka, S | 1 |
Yamakido, M | 1 |
Niimi, H | 1 |
Arimura, K | 1 |
Jonosono, M | 1 |
Hashiguchi, T | 1 |
Kawabata, M | 1 |
Osame, M | 1 |
Kitajima, I | 1 |
Kawamura, N | 1 |
Tsutsui, H | 1 |
Fukuyama, K | 1 |
Hayashidani, S | 1 |
Koike, G | 1 |
Egashira, K | 1 |
Abe, Y | 1 |
Yamamoto, H | 1 |
Tsuneyoshi, M | 1 |
Takeshita, A | 1 |
Judd, PA | 1 |
Finnegan, P | 1 |
Curran, RC | 1 |
Tsuji, S | 1 |
Akizuki, S | 1 |
Matsuoka, Y | 1 |
Irimajiri, S | 1 |
Inokuma, S | 1 |
Kitamura, H | 1 |
Kanisawa, M | 1 |
Ogiwara, T | 1 |
Takano, Y | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Prospective Study of Glucocorticoids as a Mechanism to Treat Pulmonary Hypertension[NCT04499196] | 40 participants (Anticipated) | Observational | 2020-07-29 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 reviews available for prednisolone and Hypertension, Pulmonary
Article | Year |
---|---|
The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases: report of five cases and a literature review.
Topics: Adrenal Cortex Hormones; Adult; Algorithms; Connective Tissue Diseases; Evidence-Based Medicine; Fem | 2011 |
Risk-benefit assessment in management of adult idiopathic thrombocytopenic purpura.
Topics: Adrenal Cortex Hormones; Animals; Arteriosclerosis; Cardiovascular Diseases; Diabetes Mellitus; Huma | 2011 |
[Collagen diseases with pulmonary hypertension].
Topics: Administration, Oral; Antihypertensive Agents; Calcium Channel Blockers; Collagen Diseases; Endothel | 2004 |
[Coping with pathological changes in heart and lung in collagen diseases--pulmonary hypertension].
Topics: Adult; Anti-Inflammatory Agents; Anticoagulants; Collagen Diseases; Female; Humans; Hypertension, Pu | 1996 |
39 other studies available for prednisolone and Hypertension, Pulmonary
Article | Year |
---|---|
Systemic scleroderma-related interstitial pneumonia associated with borderline pulmonary arterial hypertension.
Topics: Aged; Anti-Inflammatory Agents; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Female | 2018 |
Pulmonary hypertension and refractory heart failure in a patient with Crow-Fukase (POEMS) syndrome.
Topics: Aged; Dexamethasone; Diuretics; Drug Resistance; Edema; Furosemide; Heart Failure; Humans; Hypertens | 2013 |
Clinical case: Differential diagnosis of idiopathic pulmonary fibrosis.
Topics: Acetylcysteine; Alveolitis, Extrinsic Allergic; Azathioprine; Diagnosis, Differential; Disease Manag | 2013 |
Clinical case: Combined pulmonary fibrosis and emphysema with pulmonary hypertension--clinical management.
Topics: Acetylcysteine; Azathioprine; Disease Management; Humans; Hypertension, Pulmonary; Lung; Male; Middl | 2013 |
[Rapidly progressive pulmonary arterial hypertension associated with systemic sclerosis : a case report].
Topics: Aged; Disease Progression; Female; Humans; Hypertension, Pulmonary; Prednisolone; Scleroderma, Syste | 2013 |
Factors associated with fatigue in sarcoidosis.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Cohort Studies; Fatigue; Female; Germany; Humans; Hyp | 2014 |
Pulmonary arterial hypertension associated with IgG4-related disease.
Topics: Antibodies, Anti-Idiotypic; Autoimmune Diseases; Female; Glucocorticoids; Humans; Hypertension, Pulm | 2014 |
Pulmonary haemosiderosis with juvenile idiopathic arthritis in a Malaysian child.
Topics: Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Juvenile; Female; Hemosideros | 2007 |
[Case of systemic sclerosis sine scleroderma showing pulmonary venula lesion that suggests pulmonary veno-occlusive disease].
Topics: Aged; Female; Humans; Hypertension, Pulmonary; Methylprednisolone; Prednisolone; Pulmonary Veno-Occl | 2009 |
Acute pulmonary arterial hypertension associated with anti-synthetase syndrome.
Topics: Antibodies, Antinuclear; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Hypertensio | 2010 |
Sildenafil and steroid therapy effectively improved POEMS syndrome-associated pulmonary arterial hypertension.
Topics: Drug Therapy, Combination; Familial Primary Pulmonary Hypertension; Glucocorticoids; Humans; Hyperte | 2010 |
Prednisolone ameliorates idiopathic pulmonary arterial hypertension.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Hypertension, Pulmonary; Prednisolone; Pu | 2011 |
Long-term remission of pulmonary veno-occlusive disease associated with primary Sjögren's syndrome following immunosuppressive therapy.
Topics: Azathioprine; Female; Heart Failure; Humans; Hypertension, Pulmonary; Immunosuppressive Agents; Pred | 2011 |
Juvenile diffuse systemic sclerosis/systemic lupus erythematosus overlap syndrome--a case report.
Topics: Adolescent; Antihypertensive Agents; Arthritis; Autoantibodies; Biomarkers; Deglutition Disorders; D | 2012 |
[Successful bosentan therapy in a case of pulmonary arterial hypertention developed during immunosuppressive therapy for lupus nephritis].
Topics: Adult; Antihypertensive Agents; Bosentan; Cyclophosphamide; Drug Administration Schedule; Drug Thera | 2011 |
Pathophysiological insights from a case of reversible pulmonary arterial hypertension.
Topics: Azathioprine; Echocardiography; Humans; Hypertension, Pulmonary; Immunosuppressive Agents; Male; Mid | 2003 |
[ACUTE COR PULMONALE].
Topics: Angiotensins; Atropine; Deoxyribonuclease I; Drug Therapy; Electrocardiography; Heart Failure; Hepar | 1965 |
Autoimmune aspects of pulmonary hypertension in collagen vascular diseases.
Topics: Connective Tissue Diseases; Glucocorticoids; Humans; Hypertension, Pulmonary; Prednisolone; Sjogren' | 2003 |
Severe pulmonary hypertension associated with primary Sjögren's syndrome.
Topics: Adult; Antigen-Antibody Complex; Complement C1q; Female; Glucocorticoids; Humans; Hypertension, Pulm | 2003 |
Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.
Topics: Becaplermin; Cell Division; Cell Separation; Cell Survival; Cells, Cultured; DNA Replication; Humans | 2005 |
Drug eruption due to bosentan in a patient with systemic sclerosis.
Topics: Anti-Inflammatory Agents; Antihypertensive Agents; Bosentan; Drug Eruptions; Endothelin Receptor Ant | 2006 |
Severe pulmonary hypertension in pediatric primary Sjögren syndrome: a case report.
Topics: Antirheumatic Agents; Child; Cyclophosphamide; Female; Humans; Hypertension, Pulmonary; Prednisolone | 2007 |
Experimental study on monocrotaline induced pulmonary hypertensive rats. (1) Effect of long-term injection of immunosuppressant.
Topics: Animals; Blood Pressure; Heart Ventricles; Hypertension, Pulmonary; Immunosuppressive Agents; Inject | 1981 |
Reversible pulmonary hypertension in sarcoidosis.
Topics: Adult; Humans; Hypertension, Pulmonary; Lung Diseases; Male; Prednisolone; Sarcoidosis | 1982 |
Thiamine deficiency and pulmonary hypertension in Crow-Fukase syndrome.
Topics: Drug Therapy, Combination; Female; Humans; Hypertension, Pulmonary; Middle Aged; POEMS Syndrome; Pre | 1995 |
Increased serum angiotensin I-converting enzyme activity in patients with mixed connective tissue disease and pulmonary hypertension.
Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Female; Humans; Hypertension, Pulmonary; Male | 1995 |
Crow-Fukase syndrome associated with pulmonary hypertension.
Topics: Bone Marrow; Dyspnea; Edema; Empty Sella Syndrome; Female; Heart Failure; Humans; Hypertension, Pulm | 1993 |
Primary pulmonary hypertension in a patient with systemic lupus erythematosus: partial improvement with cyclophosphamide.
Topics: Adult; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Hypertension, Pulmonary; Lupus E | 1993 |
[Primary Sjögren's syndrome with pulmonary hypertension].
Topics: Anemia, Hemolytic; Anti-Inflammatory Agents; Cyclophosphamide; Female; Humans; Hypergammaglobulinemi | 1998 |
[Chronic thromboembolic pulmonary hypertension associated with initial pulmonary involvement in Takayasu arteritis].
Topics: Adult; Chronic Disease; Female; Humans; Hypertension, Pulmonary; Prednisolone; Pulmonary Embolism; T | 1998 |
Effective immunosuppressive therapy in a patient with primary pulmonary hypertension.
Topics: Adult; Female; Humans; Hypertension, Pulmonary; Immunosuppressive Agents; Methotrexate; Prednisolone | 1999 |
Successful treatment of systemic lupus erythematosus and pulmonary hypertension with intravenous prostaglandin I2 followed by its oral analogue.
Topics: Administration, Oral; Angiography; Drug Therapy, Combination; Epoprostenol; Female; Humans; Hyperten | 2000 |
VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome.
Topics: Cytokines; Endothelial Growth Factors; Female; Humans; Hypertension, Pulmonary; Immunosuppressive Ag | 2000 |
Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity.
Topics: Anticoagulants; Autoimmune Diseases; Calcium Channel Blockers; Disease Progression; Epoprostenol; Fa | 2002 |
Pulmonary sarcoidosis: A clinico-pathological study.
Topics: Adult; Biopsy; Female; Fibroblasts; Humans; Hypertension, Pulmonary; Inclusion Bodies; Lung; Lung Di | 1975 |
[A case of systemic lupus erythematosus complicated with pulmonary hypertension and massive pericardial effusion].
Topics: Adult; Dysgammaglobulinemia; Female; Humans; Hypertension, Pulmonary; Immunoglobulin A; Lupus Erythe | 1991 |
[Clinical study and therapy of pulmonary hypertension in systemic lupus erythematosus].
Topics: Female; Humans; Hypertension, Pulmonary; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Ma | 1990 |
Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Indome | 1989 |
[A case of MCTD with pulmonary hypertension showing elevated serum angiotensin I-converting enzyme activity].
Topics: Adult; Female; Humans; Hypertension, Pulmonary; Mixed Connective Tissue Disease; Peptidyl-Dipeptidas | 1989 |