Page last updated: 2024-11-06

prednisolone and Hypercholesterolemia

prednisolone has been researched along with Hypercholesterolemia in 22 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.

Research Excerpts

ExcerptRelevanceReference
"The therapy of nephrotic syndrome in focal segmental glomerulosclerosis (FSGS) is still a matter of controversy."6.71Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis. ( Braun, N; Fünfstück, R; Grabensee, B; Heering, P; Ivens, K; Keller, F; Krämer, BK; Müllejans, R; Risler, T; Schollmeyer, P; Zäuner, I, 2004)
"Hypercholesterolemia was observed in 46% to 80% and hypertriglyceridemia in 43% to 78% of sirolimus-treated patients during the first 6 posttransplantation months."3.72Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: incidence, risk factors, progression, and prognosis. ( Chueh, SC; Kahan, BD, 2003)
" Prophylaxis against graft-versus-host disease (GVHD) consisted of cyclosporine (CsA) and short-term methotrexate."3.72[Hypercholesterolemia as a part of chronic GVHD after allogeneic stem cell transplantation]. ( Koyama, M; Kunisaki, Y; Matsue, K; Matsuoka, K; Takeuchi, M, 2004)
" Dosing of these agents was concentration-controlled and open-labeled."2.71Bicêtre hospital experience with sirolimus-based therapy in human renal transplantation: the Sirolimus European Renal Transplant Study. ( Bäckman, L; Brattström, C; Calne, R; Campistol, JM; Charpentier, B; Claesson, K; Durand, D; Groth, CG; Kreis, H; Lang, P; Morales, JM; Touraine, JL; Wramner, L, 2003)
"The therapy of nephrotic syndrome in focal segmental glomerulosclerosis (FSGS) is still a matter of controversy."2.71Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis. ( Braun, N; Fünfstück, R; Grabensee, B; Heering, P; Ivens, K; Keller, F; Krämer, BK; Müllejans, R; Risler, T; Schollmeyer, P; Zäuner, I, 2004)
"Hypercholesterolemia was evident in 66."1.30Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation. ( Bechstein, WO; Guckelberger, O; Jonas, S; Kratschmer, B; Lemmens, HP; Luesebrink, R; Neuhaus, PL; Neuhaus, R, 1997)
" Twelve potential risk factors were evaluated as covariates: recipient age, body weight after 6 months, body weight gain over 6 months, body mass index after 6 months, body mass index gain over 6 months, current cyclosporine dosage, trough level of cyclosporine in whole blood according to high-performance liquid chromatography after 6 months, cumulative cyclosporine dosage over 6 months, serum bilirubin, type of original cardiac disease, maintenance steroids, and steroid bolus treatment."1.28The determinants of elevated total plasma cholesterol levels in cardiac transplant recipients administered low dose cyclosporine for immunosuppression. ( Grablowitz, V; Heinz, G; Laczkovics, A; Laufer, G; Miholic, J; Schreiner, W; Wolfram, J; Wollenek, G; Wolner, E, 1992)
" This change coincided with the attainment of maintenance steroid dosage (usually prednisolone 10 mg."1.26Hyperlipidaemia following renal transplantation. A study of the prevalence, 'natural history' and dietary treatment. ( Gokal, R; Mann, JI; Moore, RA; Morris, PJ, 1979)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19906 (27.27)18.7374
1990's5 (22.73)18.2507
2000's8 (36.36)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ishiguro, H1
Hashimoto, T1
Akata, M1
Suzuki, S1
Azushima, K1
Kobayashi, Y1
Kanaoka, T1
Yoshida, S1
Wakui, H1
Oshikawa, J1
Nagahama, K1
Inayama, Y1
Tamura, K1
Toya, Y1
Umemura, S1
Lin, CF1
Lee, KJ1
Yu, SS1
Lin, YS1
Nakajima, A1
Doki, K1
Homma, M1
Sagae, T1
Saito, R1
Ito, S1
Sumida, T1
Kohda, Y1
Grosch, S1
Van Overmeire, L1
Krzesinski, JM1
Bovy, C1
Charpentier, B1
Groth, CG1
Bäckman, L1
Morales, JM1
Calne, R1
Kreis, H1
Lang, P1
Touraine, JL1
Claesson, K1
Campistol, JM1
Durand, D1
Wramner, L1
Brattström, C1
Pannu, HS1
Singh, D1
Sandhu, JS1
Chueh, SC1
Kahan, BD1
BONATI, B1
RANCATI, GB1
MANFREDI, GC1
FERRARI, C1
Heering, P1
Braun, N1
Müllejans, R1
Ivens, K1
Zäuner, I1
Fünfstück, R1
Keller, F1
Krämer, BK1
Schollmeyer, P1
Risler, T1
Grabensee, B1
Koyama, M1
Matsuoka, K1
Kunisaki, Y1
Takeuchi, M1
Matsue, K1
Fassbender, WJ1
Akbas, SH1
Yurdakonar, E1
Yucetin, L1
Senol, Y1
Tuncer, M1
Kocak, H1
Akbas, M1
Gurkan, A1
Demirbas, A1
Gultekin, M1
Sokolovskaya, IV1
Nikiforova, NV1
Aakhus, S1
Dahl, K1
Widerøe, TE1
Guckelberger, O1
Bechstein, WO1
Neuhaus, R1
Luesebrink, R1
Lemmens, HP1
Kratschmer, B1
Jonas, S1
Neuhaus, PL1
Tsukahara, H1
Haruki, S1
Hiraoka, M1
Hori, C1
Sudo, M1
Gokal, R1
Mann, JI1
Moore, RA1
Morris, PJ1
Laufer, G1
Grablowitz, V1
Laczkovics, A1
Miholic, J1
Heinz, G1
Wollenek, G1
Schreiner, W1
Wolfram, J1
Wolner, E1
Ettenger, RB1
Rosenthal, JT1
Marik, J1
Grimm, PC1
Nelson, P1
Malekzadeh, MH1
Fine, RN1
Yoshimoto, K1
Saima, S1
Nakamura, Y1
Ishikawa, H1
Kinoshita, M1
Yokohari, R1
Shibata, S1
Farrow, BR1
Huxtable, CR1
Mishikawa, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA, Versus Standard Dose Tacrolimus, ECMPA Plus Corticosteroids in Patients Undergoing Liver Transplant[NCT02123108]Phase 459 participants (Actual)Interventional2011-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Participants Experiencing Acute Rejection Episode

(NCT02123108)
Timeframe: 12 months post liver transplant

InterventionParticipants (Count of Participants)
Basiliximab3
Tacrolimus Group4

Participants Experiencing Adverse Event Attributable to Study Drug

(NCT02123108)
Timeframe: 12 months post liver transplantation

InterventionParticipants (Count of Participants)
Basiliximab0
Tacrolimus Group0

Participants Experiencing Graft Failure

(NCT02123108)
Timeframe: 12 months post transplant

InterventionParticipants (Count of Participants)
Basiliximab2
Tacrolimus Group5

Renal Recovery/ Function

Number of participants who experienced dialysis independence or improvement based upon kidney function labs as a measure of renal recovery/ function following OLT in patients after undergoing orthotopic liver transplant (NCT02123108)
Timeframe: 12 months post-transplant

InterventionParticipants (Count of Participants)
Basiliximab28
Tacrolimus Group26

Survival

Participants at risk minus incidence of death within the first year post-transplant (NCT02123108)
Timeframe: 12 months post liver transplant

InterventionParticipants (Count of Participants)
Basiliximab28
Tacrolimus Group26

Trials

2 trials available for prednisolone and Hypercholesterolemia

ArticleYear
Bicêtre hospital experience with sirolimus-based therapy in human renal transplantation: the Sirolimus European Renal Transplant Study.
    Transplantation proceedings, 2003, Volume: 35, Issue:3 Suppl

    Topics: Adrenal Cortex Hormones; Azathioprine; Cyclosporine; Drug Therapy, Combination; France; Graft Reject

2003
Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 43, Issue:1

    Topics: Adult; Aged; Alkylating Agents; Biopsy; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Femal

2004

Other Studies

20 other studies available for prednisolone and Hypercholesterolemia

ArticleYear
Rituximab treatment for adult purpura nephritis with nephrotic syndrome.
    Internal medicine (Tokyo, Japan), 2013, Volume: 52, Issue:10

    Topics: Administration, Oral; Aged; Antibodies, Monoclonal, Murine-Derived; Anticholesteremic Agents; Cyclop

2013
Effect of comorbid diabetes and hypercholesterolemia on the prognosis of idiopathic sudden sensorineural hearing loss.
    The Laryngoscope, 2016, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Aged; Audiometry, Pure-Tone; Child; Comorbidity; Diabetes Complications; Female;

2016
[Investigation of glucocorticoid-induced side effects in patients with autoimmune diseases].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2009, Volume: 129, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Appetite; Autoimmune Diseases; Candidiasis, Oral; Dose-Response Rela

2009
[Fibrillary nonamyloid glomerulonephritis: a rare etiology of nephrotic syndrome].
    Nephrologie & therapeutique, 2011, Volume: 7, Issue:6

    Topics: Coloring Agents; Complement C3; Congo Red; Diagnosis, Differential; Edema; Female; Fluorobenzenes; G

2011
Lipid profile before and after renal transplantation--a longitudinal study.
    Renal failure, 2003, Volume: 25, Issue:3

    Topics: Adult; Azathioprine; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Cyclosporine

2003
Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: incidence, risk factors, progression, and prognosis.
    Transplantation, 2003, Jul-27, Volume: 76, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; Cardiovascular Diseases; Cohort Studies; Cyclosporine; Disease Prog

2003
[Effect of prednisolone on blood and tissue levels of vitamins A, C and E in rabbits on diets inducing hypercholesterolemia].
    Acta vitaminologica, 1957, Volume: 11, Issue:1

    Topics: Animals; Ascorbic Acid; Cholesterol; Diet; Hypercholesterolemia; Prednisolone; Rabbits; Vitamin A; V

1957
[Hypercholesterolemia as a part of chronic GVHD after allogeneic stem cell transplantation].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2004, Volume: 45, Issue:10

    Topics: Chronic Disease; Cyclosporine; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Hyp

2004
[Practical ambulatory therapy for multisystem atrophy and diabetes mellitus].
    Deutsche medizinische Wochenschrift (1946), 2005, Oct-14, Volume: 130, Issue:41

    Topics: Aged; Ambulatory Care; Anti-Inflammatory Agents; Calcium; Diabetes Mellitus, Type 2; Female; Humans;

2005
Relation of C-2 monitoring with serum lipid profile in stable renal transplant patients.
    Transplantation proceedings, 2006, Volume: 38, Issue:2

    Topics: Adult; Cyclosporine; Drug Therapy, Combination; Environmental Monitoring; Epidemiological Monitoring

2006
High-density lipoprotein cholesterol in patients with untreated and treated nephrotic syndrome.
    Nephron, 1984, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Cholesterol; Cholesterol, HDL; Female; Humans; Hypercholesterolemia; Hypoproteine

1984
Hyperlipidaemia in renal transplant patients.
    Journal of internal medicine, 1996, Volume: 239, Issue:5

    Topics: Adrenergic beta-Antagonists; Cardiovascular Agents; Cross-Sectional Studies; Cyclosporine; Diuretics

1996
Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation.
    Clinical transplantation, 1997, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Glucose; Cardiovascular Diseases; Cyclosporine; Female; Follow-Up Stu

1997
Persistent hypercholesterolaemia in frequently relapsing steroid-responsive nephrotic syndrome.
    Journal of paediatrics and child health, 1997, Volume: 33, Issue:3

    Topics: Adolescent; Anti-Inflammatory Agents; Child; Child, Preschool; Cholesterol; Female; Follow-Up Studie

1997
Hyperlipidaemia following renal transplantation. A study of the prevalence, 'natural history' and dietary treatment.
    The Quarterly journal of medicine, 1979, Volume: 48, Issue:192

    Topics: Adolescent; Adult; Cholesterol; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Kidney Transp

1979
The determinants of elevated total plasma cholesterol levels in cardiac transplant recipients administered low dose cyclosporine for immunosuppression.
    The Journal of thoracic and cardiovascular surgery, 1992, Volume: 104, Issue:2

    Topics: Adult; Cholesterol; Cyclosporine; Drug Therapy, Combination; Female; Heart Transplantation; Humans;

1992
Long-term results with cyclosporine immune suppression in pediatric cadaver renal transplantation.
    Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 2

    Topics: Adolescent; Age Factors; Azathioprine; Cadaver; Child; Cyclosporins; Growth; Humans; Hypercholestero

1991
[A case of acute dissecting aneurysm of the aorta in systemic lupus erythematosus].
    Nihon Jinzo Gakkai shi, 1989, Volume: 31, Issue:11

    Topics: Adult; Aortic Aneurysm; Aortic Dissection; Arteriosclerosis; Female; Humans; Hypercholesterolemia; H

1989
Membranous nephropathy and the nephrotic syndrome in the cat.
    Journal of comparative pathology, 1971, Volume: 81, Issue:4

    Topics: Animals; Cat Diseases; Cats; Edema; Female; Hypercholesterolemia; Hypoproteinemia; Kidney; Kidney Gl

1971
[Experimental studies on relation between cholesterol metabolism and endocrine function using C 14 -labelled cholesterol. 1. Effect of endocrine function on plasma cholesterol level and C 14 -labelled cholesterol metabolism in the rabbit].
    Naika hokan. Japanese archives of internal medicine, 1971, Volume: 18, Issue:9

    Topics: Anabolic Agents; Animals; Carbon Isotopes; Cholesterol; Hypercholesterolemia; Male; Oxymetholone; Pr

1971