prednisolone has been researched along with Hepatic Encephalopathy in 38 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a randomized, double-blind trial comparing 28 days of prednisolone treatment (40 mg per day) with placebo in 61 patients with biopsy-proved alcoholic hepatitis and either spontaneous hepatic encephalopathy (n = 19) or a discriminant-function value higher than 32." | 10.17 | A randomized trial of prednisolone in patients with severe alcoholic hepatitis. ( Benhamou, JP; Chaput, JC; Mathurin, P; Poynard, T; Ramond, MJ; Rueff, B; Théodore, C, 1992) |
| "Twenty-eight patients entered a double-blind controlled trial to evaluate the efficacy of prednisolone treatment in severe acute alcoholic hepatitis accompanied by encephalopathy." | 9.05 | Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy. ( Boyer, T; Depew, W; Omata, M; Redeker, A; Reynolds, T, 1980) |
| "A previous report from this institution demonstrated significant improvement of caloric intake and survival in patients with alcoholic hepatitis and hepatic encephalopathy given prednisolone when compared with placebo." | 9.04 | Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements. ( Bozymski, EM; Fallon, HJ; Lesesne, HR, 1978) |
| "We conducted a randomized, double-blind trial comparing 28 days of prednisolone treatment (40 mg per day) with placebo in 61 patients with biopsy-proved alcoholic hepatitis and either spontaneous hepatic encephalopathy (n = 19) or a discriminant-function value higher than 32." | 6.17 | A randomized trial of prednisolone in patients with severe alcoholic hepatitis. ( Benhamou, JP; Chaput, JC; Mathurin, P; Poynard, T; Ramond, MJ; Rueff, B; Théodore, C, 1992) |
| "Twenty-eight patients entered a double-blind controlled trial to evaluate the efficacy of prednisolone treatment in severe acute alcoholic hepatitis accompanied by encephalopathy." | 5.05 | Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy. ( Boyer, T; Depew, W; Omata, M; Redeker, A; Reynolds, T, 1980) |
| "In a prospective, randomized, double-blind study of prednisolone therapy of acute alcoholic hepatitis, 39% of the total group of 28 patients died." | 5.04 | Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study. ( Blitzer, BL; Conn, HO; Fessel, JM; Joshi, PH; Mutchnick, MG; Phillips, MM, 1977) |
| "A previous report from this institution demonstrated significant improvement of caloric intake and survival in patients with alcoholic hepatitis and hepatic encephalopathy given prednisolone when compared with placebo." | 5.04 | Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements. ( Bozymski, EM; Fallon, HJ; Lesesne, HR, 1978) |
| "A 10-year-old child experienced painful nodular lesions following rapid withdrawal of large doses of orally-administered prednisolone prescribed for treatment of an episode of hepatic encephalopathy." | 3.67 | Panniculitis following steroid therapy. ( Nigam, PK; Saxena, AK, 1988) |
| "Corticosteroid therapy for the treatment of alcoholic hepatitis was evaluated in nine short-term randomized clinical trials that included 150 treated and 161 control patients with a mortality rate of 37 and 44%, respectively." | 2.65 | Use of colchicine and steroids in the treatment of alcoholic liver disease. ( Galambos, JT; Riepe, SP, 1984) |
| "Severe alcoholic hepatitis (SAH) is defined by modified Maddrey discriminant function ≥32 or Model for End-Stage Liver Disease (MELD) >21 and/or hepatic encephalopathy." | 2.55 | New paradigms in management of alcoholic hepatitis: a review. ( Goyal, O; Kishore, H; Sidhu, S; Sidhu, SS, 2017) |
| "Treatment with propylthiouracil and insulin and glucagon infusions has also shown promising results in controlled studies but there is still no general agreement on their value." | 2.38 | Treatment of advanced alcoholic liver disease. ( Bird, GL; Williams, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (76.32) | 18.7374 |
| 1990's | 7 (18.42) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cortes, M | 1 |
| Vilca-Melendez, H | 1 |
| Heaton, N | 1 |
| Sidhu, SS | 1 |
| Goyal, O | 1 |
| Kishore, H | 1 |
| Sidhu, S | 1 |
| SCHMIDT, E | 1 |
| SCHMIDT, FW | 1 |
| UGARTE, G | 1 |
| PINO, ME | 1 |
| VALENZUELA, J | 1 |
| LORCA, F | 1 |
| DELPINO, D | 1 |
| BENNETT, JR | 1 |
| HOFF, WV | 1 |
| Meihoff, WE | 1 |
| Pasquale, DN | 1 |
| Jacoby, WJ | 1 |
| Seifert, E | 1 |
| Dittrich, H | 1 |
| Hölbel, I | 1 |
| Galambos, JT | 1 |
| Riepe, SP | 1 |
| Depew, W | 1 |
| Boyer, T | 1 |
| Omata, M | 1 |
| Redeker, A | 1 |
| Reynolds, T | 1 |
| Hirayama, C | 2 |
| Farber, NA | 1 |
| Gubskiĭ, LV | 1 |
| Malyshev, NA | 1 |
| Kirzhner, LS | 1 |
| Ohnishi, K | 1 |
| Torimoto, Y | 1 |
| Ohhira, M | 1 |
| Yasuda, A | 1 |
| Matsumoto, A | 1 |
| Murazumi, Y | 1 |
| Mizuno, M | 1 |
| Murazumi, K | 1 |
| Ohta, H | 1 |
| Kohda, H | 1 |
| Higuchi, D | 1 |
| Sekiyama, K | 1 |
| Yoshiba, M | 1 |
| Inoue, K | 1 |
| Fujita, R | 1 |
| Stephens, CG | 1 |
| Meadows, JG | 1 |
| Kerkering, TM | 1 |
| Markowitz, SW | 1 |
| Nisman, RM | 1 |
| Blitzer, BL | 1 |
| Mutchnick, MG | 1 |
| Joshi, PH | 1 |
| Phillips, MM | 1 |
| Fessel, JM | 1 |
| Conn, HO | 2 |
| Lesesne, HR | 2 |
| Bozymski, EM | 1 |
| Fallon, HJ | 3 |
| Kleinberger, G | 1 |
| Kotzaurek, R | 1 |
| Pall, H | 1 |
| Pichler, M | 1 |
| Weiser, M | 1 |
| Gasbarrini, G | 1 |
| Bernardi, M | 1 |
| Corazza, GR | 1 |
| Battista, P | 1 |
| Di Tano, G | 1 |
| Di Primio, R | 1 |
| Martinelli, G | 1 |
| De Leeuw, P | 1 |
| Lefebvre, C | 1 |
| Tomasi, JP | 1 |
| Rahier, J | 1 |
| Geubel, A | 1 |
| Ramond, MJ | 1 |
| Poynard, T | 1 |
| Rueff, B | 1 |
| Mathurin, P | 1 |
| Théodore, C | 1 |
| Chaput, JC | 1 |
| Benhamou, JP | 1 |
| Gorelov, VG | 1 |
| Vakharlovskiĭ, VG | 1 |
| Razevig, ND | 1 |
| Vorob'ev, AI | 1 |
| Bird, GL | 1 |
| Williams, R | 1 |
| Muto, Y | 1 |
| Murakami, N | 1 |
| Sugihara, J | 1 |
| Saxena, AK | 1 |
| Nigam, PK | 1 |
| Levina, LD | 1 |
| Kazantseva, VV | 1 |
| Fung, WP | 1 |
| Ware, AJ | 1 |
| Jones, RE | 1 |
| Shorey, JW | 1 |
| Combes, B | 1 |
| Buckner, CD | 1 |
| Clift, RA | 1 |
| Volwiler, W | 1 |
| Donohue, DM | 1 |
| Burnell, JM | 1 |
| Saunders, FC | 1 |
| Thomas, ED | 1 |
| Scheminzky, C | 1 |
| Kircher, W | 1 |
| Helman, RA | 1 |
| Temko, MH | 1 |
| Nye, SW | 1 |
| Alexander, M | 1 |
| Kludas, M | 1 |
| McMahon, JM | 1 |
| Elliott, CW | 1 |
| Green, RC | 1 |
| Liehr, H | 1 |
| Richter, E | 1 |
| Schultis, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Survival Benefit of the Adjunction of Pentoxifylline to Corticosteroids in Patients Suffering From Severe Alcoholic Hepatitis[NCT01214226] | Phase 3 | 278 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for prednisolone and Hepatic Encephalopathy
| Article | Year |
|---|---|
New paradigms in management of alcoholic hepatitis: a review.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Fecal Microbiota Transplantation; Female | 2017 |
A randomized trial of prednisolone in patients with severe alcoholic hepatitis.
Topics: Double-Blind Method; Female; Follow-Up Studies; Hepatic Encephalopathy; Hepatitis, Alcoholic; Humans | 1992 |
Treatment of advanced alcoholic liver disease.
Topics: Amino Acids; Anabolic Agents; Colchicine; Combined Modality Therapy; Hepatic Encephalopathy; Hepatit | 1990 |
Treatment of liver disease with corticosteroids.
Topics: Adrenal Cortex Hormones; Alcoholism; Azathioprine; Chemical and Drug Induced Liver Injury; Glucocort | 1973 |
8 trials available for prednisolone and Hepatic Encephalopathy
| Article | Year |
|---|---|
Use of colchicine and steroids in the treatment of alcoholic liver disease.
Topics: Clinical Trials as Topic; Colchicine; Combined Modality Therapy; Double-Blind Method; Energy Intake; | 1984 |
Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hepatic Encephalopathy; Hepatiti | 1980 |
Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study.
Topics: Acute Disease; Adrenal Cortex Hormones; Alcoholism; Alkaline Phosphatase; Aspartate Aminotransferase | 1977 |
Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements.
Topics: Adult; Clinical Trials as Topic; Energy Intake; Female; Glucose; Hepatic Encephalopathy; Hepatitis, | 1978 |
Steroid treatment of alcoholic hepatitis. The yeas and the nays.
Topics: Female; Hepatic Encephalopathy; Hepatitis, Alcoholic; Humans; Male; Prednisolone; Prognosis; Researc | 1978 |
A randomized trial of prednisolone in patients with severe alcoholic hepatitis.
Topics: Double-Blind Method; Female; Follow-Up Studies; Hepatic Encephalopathy; Hepatitis, Alcoholic; Humans | 1992 |
A controlled trial of steroid therapy in massive hepatic necrosis.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Female; Hepatic Encephalopathy; Hepati | 1974 |
Alcoholic hepatitis. Natural history and evaluation of prednisolone therapy.
Topics: Adult; Aged; Alanine Transaminase; Alcoholism; Alkaline Phosphatase; Aspartate Aminotransferases; Bi | 1971 |
27 other studies available for prednisolone and Hepatic Encephalopathy
| Article | Year |
|---|---|
The use of temporary portocaval shunt as a technical aid in auxiliary orthotopic liver transplantation.
Topics: Acetaminophen; Adolescent; Adult; Allografts; Ammonia; Analgesics, Non-Narcotic; Biopsy; Female; Gra | 2016 |
[ENZYME DETERMINATIONS IN THE SERUM IN LIVER DISEASES. FUNCTION PATTERNS AS A MEANS OF DIAGNOSIS].
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Cholecystitis; C | 1963 |
[HEPATIC COMA].
Topics: Ammonia; Arginine; Aspartate Aminotransferases; Blood; Blood Protein Electrophoresis; Clinical Labor | 1963 |
SERUM HEPATITIS PRESENTING AS SUDDEN LOSS OF CONSCIOUSNESS.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Clinical Enzyme Tests; Diagnosis, Diff | 1965 |
Tetracycline-induced hepatic coma, with recovery. Report of a case.
Topics: Adult; Female; Hepatic Encephalopathy; Humans; Prednisolone; Prednisone; Pregnancy; Pregnancy Compli | 1967 |
[On the prognosis of virus hepatitis].
Topics: Adult; Biopsy; Hepatic Encephalopathy; Hepatitis A; Humans; Liver Cirrhosis; Prednisolone; Prognosis | 1967 |
[Liver diseases. C 2. Liver cirrhosis].
Topics: Hepatic Encephalopathy; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Male; Middle Aged; P | 1982 |
[Search for and perspectives of new methods of treatment of severe forms of hepatitis B].
Topics: Adolescent; Adult; Aged; Brain Edema; Diuretics; Hepatic Encephalopathy; Hepatitis B; Humans; Hyperb | 1980 |
[A case of autoimmune hepatitis recovered from a fulminant like severe hepatic failure].
Topics: Autoimmune Diseases; Female; Glucagon; Hepatic Encephalopathy; Hepatitis; Humans; Insulin; Middle Ag | 1994 |
[A close association of prognosis with effect of interferon in HBV carriers developing acute severe exacervation].
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Carrier State; Cyclosporine; Drug | 1998 |
Spontaneous peritonitis due to Hemophilus influenzae in an adult.
Topics: Adult; Age Factors; Ascitic Fluid; Haemophilus Infections; Haemophilus influenzae; Hepatic Encephalo | 1979 |
[Effect of exchange transfusion on the plasma amino acid concentration in hepatic coma].
Topics: Adult; Amino Acids; Canrenoic Acid; Cephalothin; Exchange Transfusion, Whole Blood; Gentamicins; Hep | 1977 |
[Prospects of antilymphocyte globulin therapy of acute hepatitis].
Topics: Antilymphocyte Serum; Fever; Hepatic Encephalopathy; Hepatitis B; Hepatitis B Antigens; Humans; Lymp | 1977 |
[Severe hepatitis with encephalopathy induced by acetylsalicylic acid in a case of lupus erythematosus disseminatus].
Topics: Aspirin; Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Lupus Eryth | 1992 |
[Successful treatment of a patient with hepatolenticular degeneration with the terminal stage of liver disease].
Topics: Adult; Combined Modality Therapy; Critical Care; Hepatic Encephalopathy; Hepatolenticular Degenerati | 1991 |
[Prediction, diagnosis and therapy of fulminant hepatitis].
Topics: Amino Acids; Blood Coagulation Tests; Glucagon; Hepatic Encephalopathy; Hepatitis; Humans; Insulin; | 1990 |
Panniculitis following steroid therapy.
Topics: Child; Female; Hepatic Encephalopathy; Humans; Panniculitis; Prednisolone | 1988 |
[Treatment of hepatic coma in infectious hepatitis].
Topics: Adult; Dextrans; Drug Therapy, Combination; Female; Hepatic Encephalopathy; Hepatitis A; Humans; Hyd | 1974 |
[Acute liver insufficiency caused by toadstool poisoning].
Topics: Acute Disease; Adult; Aminophylline; Ascorbic Acid; Blood Transfusion; Drug Therapy, Combination; He | 1974 |
Clinical use of corticosteroid and immunosuppressive drugs in liver disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Biliary Tract Diseases; Chemical and D | 1974 |
Plasma exchange in patients with fulminant hepatic failure.
Topics: Adult; Arteriovenous Shunt, Surgical; Aspartate Aminotransferases; Bilirubin; Blood Platelets; Child | 1973 |
[Therapy in intoxication by Amanita phalloides in childhood].
Topics: Anti-Bacterial Agents; Bicarbonates; Child, Preschool; Diazepam; Electrolytes; Exchange Transfusion, | 1973 |
Tryptophan metabolism in liver disease.
Topics: Adult; Aged; Amino Acids; Ammonia; Brain Diseases; Chronic Disease; Diabetes Complications; Diabetes | 1971 |
[Collagen synthesis inhibition by D-penicillamine in patients with chronic, aggressive hepatitis].
Topics: Chelating Agents; Chronic Disease; Collagen; Connective Tissue; Cysteine; Female; Hepatic Encephalop | 1969 |
Steroids in alcoholic hepatitis.
Topics: Alcoholism; Female; Hepatic Encephalopathy; Hepatitis; Humans; Male; Prednisolone | 1971 |
Infectious mononucleosis complicated by hepatic coma.
Topics: Adult; Alkaline Phosphatase; Antibodies; Aspartate Aminotransferases; Cephalothin; Diagnosis, Differ | 1969 |
[Therapy of hepatic coma].
Topics: Blood Transfusion; Esophageal and Gastric Varices; Hepatic Encephalopathy; Humans; Prednisolone | 1969 |