Page last updated: 2024-11-06

prednisolone and Hepatic Encephalopathy

prednisolone has been researched along with Hepatic Encephalopathy in 38 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"We conducted a randomized, double-blind trial comparing 28 days of prednisolone treatment (40 mg per day) with placebo in 61 patients with biopsy-proved alcoholic hepatitis and either spontaneous hepatic encephalopathy (n = 19) or a discriminant-function value higher than 32."10.17A randomized trial of prednisolone in patients with severe alcoholic hepatitis. ( Benhamou, JP; Chaput, JC; Mathurin, P; Poynard, T; Ramond, MJ; Rueff, B; Théodore, C, 1992)
"Twenty-eight patients entered a double-blind controlled trial to evaluate the efficacy of prednisolone treatment in severe acute alcoholic hepatitis accompanied by encephalopathy."9.05Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy. ( Boyer, T; Depew, W; Omata, M; Redeker, A; Reynolds, T, 1980)
"A previous report from this institution demonstrated significant improvement of caloric intake and survival in patients with alcoholic hepatitis and hepatic encephalopathy given prednisolone when compared with placebo."9.04Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements. ( Bozymski, EM; Fallon, HJ; Lesesne, HR, 1978)
"We conducted a randomized, double-blind trial comparing 28 days of prednisolone treatment (40 mg per day) with placebo in 61 patients with biopsy-proved alcoholic hepatitis and either spontaneous hepatic encephalopathy (n = 19) or a discriminant-function value higher than 32."6.17A randomized trial of prednisolone in patients with severe alcoholic hepatitis. ( Benhamou, JP; Chaput, JC; Mathurin, P; Poynard, T; Ramond, MJ; Rueff, B; Théodore, C, 1992)
"Twenty-eight patients entered a double-blind controlled trial to evaluate the efficacy of prednisolone treatment in severe acute alcoholic hepatitis accompanied by encephalopathy."5.05Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy. ( Boyer, T; Depew, W; Omata, M; Redeker, A; Reynolds, T, 1980)
"In a prospective, randomized, double-blind study of prednisolone therapy of acute alcoholic hepatitis, 39% of the total group of 28 patients died."5.04Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study. ( Blitzer, BL; Conn, HO; Fessel, JM; Joshi, PH; Mutchnick, MG; Phillips, MM, 1977)
"A previous report from this institution demonstrated significant improvement of caloric intake and survival in patients with alcoholic hepatitis and hepatic encephalopathy given prednisolone when compared with placebo."5.04Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements. ( Bozymski, EM; Fallon, HJ; Lesesne, HR, 1978)
"A 10-year-old child experienced painful nodular lesions following rapid withdrawal of large doses of orally-administered prednisolone prescribed for treatment of an episode of hepatic encephalopathy."3.67Panniculitis following steroid therapy. ( Nigam, PK; Saxena, AK, 1988)
"Corticosteroid therapy for the treatment of alcoholic hepatitis was evaluated in nine short-term randomized clinical trials that included 150 treated and 161 control patients with a mortality rate of 37 and 44%, respectively."2.65Use of colchicine and steroids in the treatment of alcoholic liver disease. ( Galambos, JT; Riepe, SP, 1984)
"Severe alcoholic hepatitis (SAH) is defined by modified Maddrey discriminant function ≥32 or Model for End-Stage Liver Disease (MELD) >21 and/or hepatic encephalopathy."2.55New paradigms in management of alcoholic hepatitis: a review. ( Goyal, O; Kishore, H; Sidhu, S; Sidhu, SS, 2017)
"Treatment with propylthiouracil and insulin and glucagon infusions has also shown promising results in controlled studies but there is still no general agreement on their value."2.38Treatment of advanced alcoholic liver disease. ( Bird, GL; Williams, R, 1990)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199029 (76.32)18.7374
1990's7 (18.42)18.2507
2000's0 (0.00)29.6817
2010's2 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cortes, M1
Vilca-Melendez, H1
Heaton, N1
Sidhu, SS1
Goyal, O1
Kishore, H1
Sidhu, S1
SCHMIDT, E1
SCHMIDT, FW1
UGARTE, G1
PINO, ME1
VALENZUELA, J1
LORCA, F1
DELPINO, D1
BENNETT, JR1
HOFF, WV1
Meihoff, WE1
Pasquale, DN1
Jacoby, WJ1
Seifert, E1
Dittrich, H1
Hölbel, I1
Galambos, JT1
Riepe, SP1
Depew, W1
Boyer, T1
Omata, M1
Redeker, A1
Reynolds, T1
Hirayama, C2
Farber, NA1
Gubskiĭ, LV1
Malyshev, NA1
Kirzhner, LS1
Ohnishi, K1
Torimoto, Y1
Ohhira, M1
Yasuda, A1
Matsumoto, A1
Murazumi, Y1
Mizuno, M1
Murazumi, K1
Ohta, H1
Kohda, H1
Higuchi, D1
Sekiyama, K1
Yoshiba, M1
Inoue, K1
Fujita, R1
Stephens, CG1
Meadows, JG1
Kerkering, TM1
Markowitz, SW1
Nisman, RM1
Blitzer, BL1
Mutchnick, MG1
Joshi, PH1
Phillips, MM1
Fessel, JM1
Conn, HO2
Lesesne, HR2
Bozymski, EM1
Fallon, HJ3
Kleinberger, G1
Kotzaurek, R1
Pall, H1
Pichler, M1
Weiser, M1
Gasbarrini, G1
Bernardi, M1
Corazza, GR1
Battista, P1
Di Tano, G1
Di Primio, R1
Martinelli, G1
De Leeuw, P1
Lefebvre, C1
Tomasi, JP1
Rahier, J1
Geubel, A1
Ramond, MJ1
Poynard, T1
Rueff, B1
Mathurin, P1
Théodore, C1
Chaput, JC1
Benhamou, JP1
Gorelov, VG1
Vakharlovskiĭ, VG1
Razevig, ND1
Vorob'ev, AI1
Bird, GL1
Williams, R1
Muto, Y1
Murakami, N1
Sugihara, J1
Saxena, AK1
Nigam, PK1
Levina, LD1
Kazantseva, VV1
Fung, WP1
Ware, AJ1
Jones, RE1
Shorey, JW1
Combes, B1
Buckner, CD1
Clift, RA1
Volwiler, W1
Donohue, DM1
Burnell, JM1
Saunders, FC1
Thomas, ED1
Scheminzky, C1
Kircher, W1
Helman, RA1
Temko, MH1
Nye, SW1
Alexander, M1
Kludas, M1
McMahon, JM1
Elliott, CW1
Green, RC1
Liehr, H1
Richter, E1
Schultis, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Survival Benefit of the Adjunction of Pentoxifylline to Corticosteroids in Patients Suffering From Severe Alcoholic Hepatitis[NCT01214226]Phase 3278 participants (Actual)Interventional2007-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for prednisolone and Hepatic Encephalopathy

ArticleYear
New paradigms in management of alcoholic hepatitis: a review.
    Hepatology international, 2017, Volume: 11, Issue:3

    Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Fecal Microbiota Transplantation; Female

2017
A randomized trial of prednisolone in patients with severe alcoholic hepatitis.
    The New England journal of medicine, 1992, Feb-20, Volume: 326, Issue:8

    Topics: Double-Blind Method; Female; Follow-Up Studies; Hepatic Encephalopathy; Hepatitis, Alcoholic; Humans

1992
Treatment of advanced alcoholic liver disease.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1990, Volume: 25, Issue:2-3

    Topics: Amino Acids; Anabolic Agents; Colchicine; Combined Modality Therapy; Hepatic Encephalopathy; Hepatit

1990
Treatment of liver disease with corticosteroids.
    The Medical clinics of North America, 1973, Volume: 57, Issue:5

    Topics: Adrenal Cortex Hormones; Alcoholism; Azathioprine; Chemical and Drug Induced Liver Injury; Glucocort

1973

Trials

8 trials available for prednisolone and Hepatic Encephalopathy

ArticleYear
Use of colchicine and steroids in the treatment of alcoholic liver disease.
    Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism, 1984, Volume: 2

    Topics: Clinical Trials as Topic; Colchicine; Combined Modality Therapy; Double-Blind Method; Energy Intake;

1984
Double-blind controlled trial of prednisolone therapy in patients with severe acute alcoholic hepatitis and spontaneous encephalopathy.
    Gastroenterology, 1980, Volume: 78, Issue:3

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hepatic Encephalopathy; Hepatiti

1980
Adrenocorticosteroid therapy in alcoholic hepatitis. A prospective, double-blind randomized study.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:6

    Topics: Acute Disease; Adrenal Cortex Hormones; Alcoholism; Alkaline Phosphatase; Aspartate Aminotransferase

1977
Treatment of alcoholic hepatitis with encephalopathy. Comparison of prednisolone with caloric supplements.
    Gastroenterology, 1978, Volume: 74, Issue:2 Pt 1

    Topics: Adult; Clinical Trials as Topic; Energy Intake; Female; Glucose; Hepatic Encephalopathy; Hepatitis,

1978
Steroid treatment of alcoholic hepatitis. The yeas and the nays.
    Gastroenterology, 1978, Volume: 74, Issue:2 Pt 1

    Topics: Female; Hepatic Encephalopathy; Hepatitis, Alcoholic; Humans; Male; Prednisolone; Prognosis; Researc

1978
A randomized trial of prednisolone in patients with severe alcoholic hepatitis.
    The New England journal of medicine, 1992, Feb-20, Volume: 326, Issue:8

    Topics: Double-Blind Method; Female; Follow-Up Studies; Hepatic Encephalopathy; Hepatitis, Alcoholic; Humans

1992
A controlled trial of steroid therapy in massive hepatic necrosis.
    The American journal of gastroenterology, 1974, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Female; Hepatic Encephalopathy; Hepati

1974
Alcoholic hepatitis. Natural history and evaluation of prednisolone therapy.
    Annals of internal medicine, 1971, Volume: 74, Issue:3

    Topics: Adult; Aged; Alanine Transaminase; Alcoholism; Alkaline Phosphatase; Aspartate Aminotransferases; Bi

1971

Other Studies

27 other studies available for prednisolone and Hepatic Encephalopathy

ArticleYear
The use of temporary portocaval shunt as a technical aid in auxiliary orthotopic liver transplantation.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2016, Volume: 22, Issue:11

    Topics: Acetaminophen; Adolescent; Adult; Allografts; Ammonia; Analgesics, Non-Narcotic; Biopsy; Female; Gra

2016
[ENZYME DETERMINATIONS IN THE SERUM IN LIVER DISEASES. FUNCTION PATTERNS AS A MEANS OF DIAGNOSIS].
    Enzymologia biologica et clinica, 1963, Volume: 79

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Cholecystitis; C

1963
[HEPATIC COMA].
    Revista medica de Chile, 1963, Volume: 91

    Topics: Ammonia; Arginine; Aspartate Aminotransferases; Blood; Blood Protein Electrophoresis; Clinical Labor

1963
SERUM HEPATITIS PRESENTING AS SUDDEN LOSS OF CONSCIOUSNESS.
    British medical journal, 1965, Mar-13, Volume: 1, Issue:5436

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Clinical Enzyme Tests; Diagnosis, Diff

1965
Tetracycline-induced hepatic coma, with recovery. Report of a case.
    Obstetrics and gynecology, 1967, Volume: 29, Issue:2

    Topics: Adult; Female; Hepatic Encephalopathy; Humans; Prednisolone; Prednisone; Pregnancy; Pregnancy Compli

1967
[On the prognosis of virus hepatitis].
    Gastroenterologia, 1967, Volume: 107, Issue:5

    Topics: Adult; Biopsy; Hepatic Encephalopathy; Hepatitis A; Humans; Liver Cirrhosis; Prednisolone; Prognosis

1967
[Liver diseases. C 2. Liver cirrhosis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1982, May-10, Volume: 71, Issue:5

    Topics: Hepatic Encephalopathy; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Male; Middle Aged; P

1982
[Search for and perspectives of new methods of treatment of severe forms of hepatitis B].
    Terapevticheskii arkhiv, 1980, Volume: 52, Issue:11

    Topics: Adolescent; Adult; Aged; Brain Edema; Diuretics; Hepatic Encephalopathy; Hepatitis B; Humans; Hyperb

1980
[A case of autoimmune hepatitis recovered from a fulminant like severe hepatic failure].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1994, Volume: 91, Issue:9

    Topics: Autoimmune Diseases; Female; Glucagon; Hepatic Encephalopathy; Hepatitis; Humans; Insulin; Middle Ag

1994
[A close association of prognosis with effect of interferon in HBV carriers developing acute severe exacervation].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1998, Volume: 95, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Carrier State; Cyclosporine; Drug

1998
Spontaneous peritonitis due to Hemophilus influenzae in an adult.
    Gastroenterology, 1979, Volume: 77, Issue:5

    Topics: Adult; Age Factors; Ascitic Fluid; Haemophilus Infections; Haemophilus influenzae; Hepatic Encephalo

1979
[Effect of exchange transfusion on the plasma amino acid concentration in hepatic coma].
    Zeitschrift fur Gastroenterologie, 1977, Volume: 15, Issue:1

    Topics: Adult; Amino Acids; Canrenoic Acid; Cephalothin; Exchange Transfusion, Whole Blood; Gentamicins; Hep

1977
[Prospects of antilymphocyte globulin therapy of acute hepatitis].
    Bollettino della Societa italiana di biologia sperimentale, 1977, Nov-15, Volume: 53, Issue:21

    Topics: Antilymphocyte Serum; Fever; Hepatic Encephalopathy; Hepatitis B; Hepatitis B Antigens; Humans; Lymp

1977
[Severe hepatitis with encephalopathy induced by acetylsalicylic acid in a case of lupus erythematosus disseminatus].
    Gastroenterologie clinique et biologique, 1992, Volume: 16, Issue:4

    Topics: Aspirin; Chemical and Drug Induced Liver Injury; Female; Hepatic Encephalopathy; Humans; Lupus Eryth

1992
[Successful treatment of a patient with hepatolenticular degeneration with the terminal stage of liver disease].
    Gematologiia i transfuziologiia, 1991, Volume: 36, Issue:4

    Topics: Adult; Combined Modality Therapy; Critical Care; Hepatic Encephalopathy; Hepatolenticular Degenerati

1991
[Prediction, diagnosis and therapy of fulminant hepatitis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1990, Aug-10, Volume: 79, Issue:8

    Topics: Amino Acids; Blood Coagulation Tests; Glucagon; Hepatic Encephalopathy; Hepatitis; Humans; Insulin;

1990
Panniculitis following steroid therapy.
    Cutis, 1988, Volume: 42, Issue:4

    Topics: Child; Female; Hepatic Encephalopathy; Humans; Panniculitis; Prednisolone

1988
[Treatment of hepatic coma in infectious hepatitis].
    Klinicheskaia meditsina, 1974, Volume: 52, Issue:6

    Topics: Adult; Dextrans; Drug Therapy, Combination; Female; Hepatic Encephalopathy; Hepatitis A; Humans; Hyd

1974
[Acute liver insufficiency caused by toadstool poisoning].
    Vrachebnoe delo, 1974, Volume: 0, Issue:7

    Topics: Acute Disease; Adult; Aminophylline; Ascorbic Acid; Blood Transfusion; Drug Therapy, Combination; He

1974
Clinical use of corticosteroid and immunosuppressive drugs in liver disease.
    Drugs, 1974, Volume: 8, Issue:2

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Biliary Tract Diseases; Chemical and D

1974
Plasma exchange in patients with fulminant hepatic failure.
    Archives of internal medicine, 1973, Volume: 132, Issue:4

    Topics: Adult; Arteriovenous Shunt, Surgical; Aspartate Aminotransferases; Bilirubin; Blood Platelets; Child

1973
[Therapy in intoxication by Amanita phalloides in childhood].
    Padiatrie und Padologie, 1973, Volume: 8, Issue:1

    Topics: Anti-Bacterial Agents; Bicarbonates; Child, Preschool; Diazepam; Electrolytes; Exchange Transfusion,

1973
Tryptophan metabolism in liver disease.
    Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 32, Issue:2

    Topics: Adult; Aged; Amino Acids; Ammonia; Brain Diseases; Chronic Disease; Diabetes Complications; Diabetes

1971
[Collagen synthesis inhibition by D-penicillamine in patients with chronic, aggressive hepatitis].
    Munchener medizinische Wochenschrift (1950), 1969, Apr-11, Volume: 111, Issue:15

    Topics: Chelating Agents; Chronic Disease; Collagen; Connective Tissue; Cysteine; Female; Hepatic Encephalop

1969
Steroids in alcoholic hepatitis.
    Annals of internal medicine, 1971, Volume: 75, Issue:2

    Topics: Alcoholism; Female; Hepatic Encephalopathy; Hepatitis; Humans; Male; Prednisolone

1971
Infectious mononucleosis complicated by hepatic coma.
    The American journal of gastroenterology, 1969, Volume: 51, Issue:3

    Topics: Adult; Alkaline Phosphatase; Antibodies; Aspartate Aminotransferases; Cephalothin; Diagnosis, Differ

1969
[Therapy of hepatic coma].
    Die Medizinische Welt, 1969, May-17, Volume: 20

    Topics: Blood Transfusion; Esophageal and Gastric Varices; Hepatic Encephalopathy; Humans; Prednisolone

1969