Page last updated: 2024-11-06

prednisolone and Glucose Intolerance

prednisolone has been researched along with Glucose Intolerance in 10 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.

Research Excerpts

ExcerptRelevanceReference
"Increased prednisolone dose and older age are strongly associated with the development of posttransplant glucose intolerance."7.69Glucose intolerance after renal transplantation depends upon prednisolone dose and recipient age. ( Egeland, T; Fauchald, P; Hartmann, A; Hjelmesaeth, J; Kofstad, J; Leivestad, T; Stenstrøm, J, 1997)
"Men with the metabolic syndrome but without diabetes received prednisolone 30  mg once daily plus sitagliptin 100  mg once daily (n=14), prednisolone (n=12) or sitagliptin alone (n=14) or placebo (n=12) for 14 days in a double-blind 2 × 2 randomized-controlled study."5.19Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial. ( Diamant, M; Heymans, MW; Mari, A; Muskiet, MH; Ouwens, DM; Pouwels, PJ; van Genugten, RE; van Raalte, DH, 2014)
" Intravenous boluses of cyclophosphamide (IVCY) with oral prednisolone and cyclosporin A induced remission of SLE, and a subsequent disappearance of anti-insulin receptor autoantibodies, followed by a recovery of glucose intolerance."3.76Type B insulin resistance complicated with systemic lupus erythematosus. ( Aramaki, T; Eguchi, K; Fujikawa, K; Ida, H; Iwamoto, N; Kawakami, A; Kawashiri, SY; Nakamura, H; Origuchi, T; Tamai, M, 2010)
" This study reports the use of a large dose of prednisolone to evaluate the effects of EA in a state of insulin resistance."3.75Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background male rats. ( Chang, SL; Cheng, JT; Ho, WJ; Lee, YC; Lin, JG; Lin, RT; Tzeng, CY, 2009)
"Increased prednisolone dose and older age are strongly associated with the development of posttransplant glucose intolerance."3.69Glucose intolerance after renal transplantation depends upon prednisolone dose and recipient age. ( Egeland, T; Fauchald, P; Hartmann, A; Hjelmesaeth, J; Kofstad, J; Leivestad, T; Stenstrøm, J, 1997)
"Both Mikulicz's disease and autoimmune pancreatitis presented with elevated serum IgG4 and infiltration of IgG4-expressing plasma cells into the glandular tissues."1.33[A case of Mikulicz's disease complicated by autoimmune pancreatitis, in which impaired glucose tolerance was improved by glucocorticoid treatment]. ( Imai, K; Naishiro, Y; Ohara, M; Oka, T; Shinomura, Y; Suzuki, C; Takahashi, H; Yamamoto, H; Yamamoto, M, 2005)
"Glucose intolerance is an untoward side effect of some immunosuppressive and anti-hypertensive drugs."1.31Tapering off prednisolone and cyclosporin the first year after renal transplantation: the effect on glucose tolerance. ( Egeland, T; Fauchald, P; Hartmann, A; Hjelmesaeth, J; Kofstad, J; Stenstrøm, J, 2001)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's3 (30.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Noguchi, K1
Nakai, Y1
Mizuno, S1
Isayama, H1
Hirano, K1
Kanai, S1
Nakamura, T1
Uchino, R1
Takahara, N1
Kogure, H1
Tada, M1
Koike, K1
van Genugten, RE1
van Raalte, DH1
Muskiet, MH1
Heymans, MW1
Pouwels, PJ1
Ouwens, DM1
Mari, A1
Diamant, M1
Lin, RT1
Tzeng, CY1
Lee, YC1
Ho, WJ1
Cheng, JT1
Lin, JG1
Chang, SL1
Kawashiri, SY1
Kawakami, A1
Fujikawa, K1
Iwamoto, N1
Aramaki, T1
Tamai, M1
Nakamura, H1
Origuchi, T1
Ida, H1
Eguchi, K1
Yamamoto, M1
Ohara, M1
Suzuki, C1
Oka, T1
Naishiro, Y1
Yamamoto, H1
Takahashi, H1
Shinomura, Y1
Imai, K1
Hokken-Koelega, AC1
Hjelmesaeth, J2
Hartmann, A2
Kofstad, J2
Stenstrøm, J2
Leivestad, T1
Egeland, T2
Fauchald, P2
Uchida, K1
Tominaga, Y1
Haba, T1
Katayama, A1
Ichimori, T1
Yamada, K1
Hibi, Y1
Uemura, O1
Morozumi, K1
Takagi, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism and Beta-Cell Dysfunction in Males With the Metabolic Syndrome X: A Randomized, Placebo-controlled, Double-blind Intervention Study With a 2x2 Factorial Design[NCT00721552]82 participants (Actual)Interventional2008-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for prednisolone and Glucose Intolerance

ArticleYear
Deflazacort--an alternative to prednisolone?
    Drug and therapeutics bulletin, 1999, Volume: 37, Issue:8

    Topics: Adult; Anti-Inflammatory Agents; Child; Glucocorticoids; Glucose Intolerance; Humans; Prednisolone;

1999

Trials

2 trials available for prednisolone and Glucose Intolerance

ArticleYear
Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.
    European journal of endocrinology, 2014, Volume: 170, Issue:3

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; F

2014
Decreasing pancreatic toxicity of tacrolimus by dosage reduction.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Administration, Oral; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Thera

1998

Other Studies

7 other studies available for prednisolone and Glucose Intolerance

ArticleYear
Insulin secretion improvement during steroid therapy for autoimmune pancreatitis according to the onset of diabetes mellitus.
    Journal of gastroenterology, 2020, Volume: 55, Issue:2

    Topics: Aged; Anti-Inflammatory Agents; Atrophy; Autoimmune Pancreatitis; Blood Glucose; C-Peptide; Diabetes

2020
Acute effect of electroacupuncture at the Zusanli acupoints on decreasing insulin resistance as shown by lowering plasma free fatty acid levels in steroid-background male rats.
    BMC complementary and alternative medicine, 2009, Aug-01, Volume: 9

    Topics: Acupuncture Points; Animals; Blood Glucose; Disease Models, Animal; Electroacupuncture; Fatty Acids,

2009
Type B insulin resistance complicated with systemic lupus erythematosus.
    Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:5

    Topics: Autoantibodies; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Glucose Intolerance; Huma

2010
[A case of Mikulicz's disease complicated by autoimmune pancreatitis, in which impaired glucose tolerance was improved by glucocorticoid treatment].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2005, Volume: 28, Issue:5

    Topics: Aged; Autoimmune Diseases; Female; Glucocorticoids; Glucose Intolerance; Humans; Mikulicz' Disease;

2005
Can glucose intolerance and/or diabetes be predicted in patients treated with rhGH?
    British journal of clinical practice. Supplement, 1996, Volume: 85

    Topics: Child; Diabetes Mellitus; Glucose Intolerance; Human Growth Hormone; Humans; Kidney Transplantation;

1996
Glucose intolerance after renal transplantation depends upon prednisolone dose and recipient age.
    Transplantation, 1997, Oct-15, Volume: 64, Issue:7

    Topics: Adult; Age Factors; Cyclosporine; Diabetes Mellitus; Dose-Response Relationship, Drug; Family; Femal

1997
Tapering off prednisolone and cyclosporin the first year after renal transplantation: the effect on glucose tolerance.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents; Cyclosporine; Female; Glucose Intolerance; Glucose Tolerance

2001