prednisolone has been researched along with Gaucher Disease in 3 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In type I Gaucher's disease, episodes of severe disabling bone pain, the so called bone crises, may be resistant to all analgesics, including narcotics." | 5.29 | Effective treatment of painful bone crises in type I gaucher's disease with high dose prednisolone. ( Cohen, IJ; Katz, K; Kornreich, L; Mekhmandarov, S; Zaizov, R, 1996) |
| "In type I Gaucher's disease, episodes of severe disabling bone pain, the so called bone crises, may be resistant to all analgesics, including narcotics." | 1.29 | Effective treatment of painful bone crises in type I gaucher's disease with high dose prednisolone. ( Cohen, IJ; Katz, K; Kornreich, L; Mekhmandarov, S; Zaizov, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| YAMANA, M | 1 |
| INOUE, O | 1 |
| MORIYA, J | 1 |
| Cohen, IJ | 1 |
| Kornreich, L | 1 |
| Mekhmandarov, S | 1 |
| Katz, K | 1 |
| Zaizov, R | 1 |
| Elstein, D | 1 |
| Abrahamov, A | 1 |
| Itzchaki, M | 1 |
| Zimran, A | 1 |
3 other studies available for prednisolone and Gaucher Disease
| Article | Year |
|---|---|
[ON A CASE OF FAMILIAL GAUCHER'S DISEASE].
Topics: Child; Diagnosis; Gaucher Disease; Genetics, Medical; Humans; Pathology; Prednisolone | 1964 |
Effective treatment of painful bone crises in type I gaucher's disease with high dose prednisolone.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Bone Diseases; Child; Drug Therapy, Combination; Gauche | 1996 |
Commentary: low-dose high-frequency enzyme replacement therapy prevents fractures without complete suppression of painful bone crises in patients with severe juvenile onset type I Gaucher disease.
Topics: Adolescent; Adult; Age Factors; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Ste | 1998 |