Page last updated: 2024-11-06

prednisolone and Fasting Hypoglycemia

prednisolone has been researched along with Fasting Hypoglycemia in 43 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.

Research Excerpts

ExcerptRelevanceReference
"In this retrospective case series, we found no evidence of prolonged effects of maternal prednisolone use during pregnancy on the neonatal hypothalamic-pituitary-adrenal axis."3.85Maternal use of prednisolone is unlikely to be associated with neonatal adrenal suppression-a single-center study of 16 cases. ( Bocca, G; de Vetten, L; Kema, IP; van Stuijvenberg, M, 2017)
" He was recently discharged following a 50-day hospital stay with newly diagnosed microscopic polyangiitis, complicated by pulmonary haemorrhage and severe renal dysfunction requiring renal replacement therapy, plasma exchange and immunosuppression (cyclophosphamide and methylprednisolone)."3.85Severe co-trimoxazole-induced hypoglycaemia in a patient with microscopic polyangiitis. ( Conley, TE; Mohiuddin, A; Naz, N, 2017)
"A new diagnosis of unresectable hepatocellular carcinoma (HCC) was made."1.72The palliative management of non-islet cell tumour hypoglycaemia with glucocorticoids and somatostatin analogues in an unresectable hepatocellular carcinoma. ( Hammond, JS; James, RA; North, AS; Thakkar, RG, 2022)
"Insulinoma was excluded by detailed endocrine assessment."1.48Insulin Autoimmune Syndrome: a rare case of hypoglycaemia resolving with immunosuppression. ( Graham, U; Hunter, A; Lindsay, JR, 2018)
"Sheehan syndrome is a rare but potentially serious complication of postpartum haemorrhage."1.40Recurrent hypoglycaemia: a delayed presentation of Sheehan syndrome. ( Dhanwal, DK; Kumar, J; Kumar, N; Singh, P, 2014)
"Insulinoma was diagnosed based on fasting blood glucose level of 15 mg/dl, high fasting immunoreactive insulin/blood glucose ratio (more than 0."1.34Insulinoma with early-morning abnormal behavior. ( Hirata, K; Miyamoto, M; Miyamoto, T; Suzuki, K, 2007)
"Prednisolone was replaced to a lower dosage dexamethasone (2 mg/day)."1.33Hepatocellular carcinoma with persistent hypoglycemia: successful treatment with corticosteroid and frequent high carbohydrate intake. ( Bubpha, P; Thipaporn, T; Varaphon, V, 2005)
"Hypoglycemia was repeated despite infusion of glucose and glucagon."1.33Glucocorticoid therapy ameliorated hypoglycemia in insulin-like growth factor-II-producing solitary fibrous tumor. ( Fujimoto, M; Fukui, H; Kojima, H; Kou, S; Nakajima, Y; Nakamura, T; Okamoto, S; Tsuro, K; Uemura, M; Yoshiji, H; Yoshikawa, M, 2006)
"Surgical removal of the malignancy, where this was an option, was successful within the periods studied."1.32The effectiveness of different treatment options for non-islet cell tumour hypoglycaemia. ( Teale, JD; Wark, G, 2004)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199018 (41.86)18.7374
1990's3 (6.98)18.2507
2000's13 (30.23)29.6817
2010's8 (18.60)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
North, AS1
Thakkar, RG1
James, RA1
Hammond, JS1
de Vetten, L1
van Stuijvenberg, M1
Kema, IP2
Bocca, G1
Hunter, A1
Graham, U1
Lindsay, JR1
Kumar, N1
Singh, P1
Kumar, J1
Dhanwal, DK1
Moore, AR1
Chu, C1
Singh, K1
Barger, AM1
Schnelle, AN1
Radhakutty, A1
Stranks, JL1
Mangelsdorf, BL1
Drake, SM1
Roberts, GW1
Zimmermann, AT1
Stranks, SN1
Thompson, CH1
Burt, MG1
Conley, TE1
Mohiuddin, A1
Naz, N1
Lupsa, BC1
Chong, AY1
Cochran, EK1
Soos, MA1
Semple, RK1
Gorden, P1
Lee, Y1
Jung, HS1
Choi, HJ1
Kim, MJ1
Kim, TM1
Park, KS1
Kim, SY1
Kulaksızoglu, M1
Gonen, MS1
Kebapcilar, L1
Sahin, F1
Demirci, F1
Topcu, A1
Basu, M1
Sawhney, RC1
Kumar, S1
Pal, K1
Prasad, R1
Selvamurthy, W1
Plikat, K1
Reichle, A1
Elmlinger, MW1
Schölmerich, J1
Sari, R1
Altunbas, H1
Ozdogan, M1
Gurer, EI1
Karayalcin, U1
LLOYD, JK1
Teale, JD2
Wark, G1
Shibata, C1
Funayama, Y1
Fukushima, K1
Shiiba, K1
Sasaki, I1
Itoi, K1
Naito, H1
Sundell, J1
Ala-Houhala, M1
Lewitt, M1
Laine, H1
Nuutila, P1
Koyama, R1
Nakanishi, K1
Kato, M1
Yamashita, S1
Kuwahara, H1
Katori, H1
Thipaporn, T1
Bubpha, P1
Varaphon, V1
Tsuro, K1
Kojima, H1
Okamoto, S1
Yoshiji, H1
Fujimoto, M1
Uemura, M1
Yoshikawa, M1
Nakamura, T1
Kou, S1
Nakajima, Y1
Fukui, H1
Suzuki, K1
Miyamoto, M1
Miyamoto, T1
Hirata, K1
Kato, Y1
Ichiki, Y1
Kitajima, Y1
Perros, P1
Simpson, J1
Innes, JA1
McKnight, JA1
Shotliff, KP1
Allen, A1
Nussey, SS1
Kerstens, MN1
Hoogenberg, K1
Minkema, HJ1
Dullaart, RP1
Satterfield, RG1
Williamson, HO1
Tiller, R1
Lange, J1
Kremss, B1
Manniello, RL1
Schulman, JD1
Farrell, PM1
Ichikawa, K1
Nishii, Y1
Hashizume, K1
Chino, M1
Nagasawa, T1
Suzuki, S1
Okada, N1
Kobayashi, M1
Koizumi, Y1
Arai, M1
Rodger, RS1
Watson, MJ1
Sellars, L1
Wilkinson, R1
Ward, MK1
Kerr, DN1
Abel, HT1
Fünfhausen, H1
Korb, C1
Lamme, W1
Kleinhans, F1
Muszbek, L1
Csaba, B1
Kovács, K1
Csizér, Z1
Nakagawa, S1
Suda, N1
Kudo, M1
Kawasaki, M1
Malone, DN1
Grant, IW1
Percy-Robb, IW1
Radó, JP1
Takó, J1
Salamon, F1
Loczka, B1
Major, E1
Carter, ME1
James, VH1
Takeda, R1
Nakabayashi, H1
Usukura, N1
Hosojima, H1
Kawato, M1
Ueda, M1
Astvatsatrian, VA1
Matevosian, EG1
Winkelmann, W1
Katsumata, K1
Yamada, K1
Talamo, RC1
Hendren, WH1
Plumpton, FS2
Besser, GM2
Cole, PV1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of Neutral Protamine Hagedorn (NPH) Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia[NCT03511521]Phase 43 participants (Actual)Interventional2018-03-27Terminated (stopped due to Unable to recruit sufficient number of patients)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Glycemic Control

mean of 4 glucose levels per day (premeal and bedtime) for each group for first 3 days after intervention (NCT03511521)
Timeframe: 3 days

Interventionmg/dL (Mean)
NPH Insulin284.3
Basal/Bolus Insulin184.3

Percentage of Glucose Values Within the Hypoglycemic Range

Percentage of the glucose values (premeal and bedtime for 3 days) less than 70 mg/dL and 54 mg/dL (NCT03511521)
Timeframe: 3 days

InterventionPercentage of glucose values < 70 mg/dL (Mean)
NPH Insulin0
Basal/Bolus Insulin0

Percentage of Glucose Values Within Therapeutic Range

Percentage of the glucose values (premeal and bedtime for 3 days) within the therapeutic target of 80 - 180 mg/dL (NCT03511521)
Timeframe: 3 days

Interventionpercentage of glucose values in range (Mean)
NPH Insulin4.2
Basal/Bolus Insulin50

Reviews

2 reviews available for prednisolone and Fasting Hypoglycemia

ArticleYear
Autoimmune forms of hypoglycemia.
    Medicine, 2009, Volume: 88, Issue:3

    Topics: Aged; Autoantibodies; Autoimmune Diseases; Glucocorticoids; Humans; Hypoglycemia; Insulin; Insulin R

2009
[Elevated hormone levels without endocrinopathy: hypercortisoluria and hypoglycemia as facticious disorders].
    Nederlands tijdschrift voor geneeskunde, 2001, Mar-31, Volume: 145, Issue:13

    Topics: Adrenocortical Hyperfunction; Adult; Diabetes Mellitus; Diagnosis, Differential; Factitious Disorder

2001

Trials

2 trials available for prednisolone and Fasting Hypoglycemia

ArticleYear
Treatment of prednisolone-induced hyperglycaemia in hospitalized patients: Insights from a randomized, controlled study.
    Diabetes, obesity & metabolism, 2017, Volume: 19, Issue:4

    Topics: Aged; Blood Glucose; Drug Administration Schedule; Female; Hospitalization; Humans; Hyperglycemia; H

2017
Hypothalamic-pituitary-adrenal axis following glucocorticoid prophylaxis against acute mountain sickness.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2002, Volume: 34, Issue:6

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Altitude Sickness; Blood Glucose; Epinephrine; G

2002

Other Studies

39 other studies available for prednisolone and Fasting Hypoglycemia

ArticleYear
The palliative management of non-islet cell tumour hypoglycaemia with glucocorticoids and somatostatin analogues in an unresectable hepatocellular carcinoma.
    Annals of the Royal College of Surgeons of England, 2022, Volume: 104, Issue:6

    Topics: Aged; Carbohydrates; Carcinoma, Hepatocellular; Female; Glucocorticoids; Humans; Hypoglycemia; Hypog

2022
Maternal use of prednisolone is unlikely to be associated with neonatal adrenal suppression-a single-center study of 16 cases.
    European journal of pediatrics, 2017, Volume: 176, Issue:8

    Topics: Adrenal Insufficiency; Female; Follow-Up Studies; Glucocorticoids; Humans; Hypoglycemia; Hypothalamo

2017
Insulin Autoimmune Syndrome: a rare case of hypoglycaemia resolving with immunosuppression.
    The Ulster medical journal, 2018, Volume: 87, Issue:1

    Topics: Autoimmune Diseases; Diagnosis, Differential; Humans; Hypoglycemia; Immunosuppressive Agents; Insuli

2018
Recurrent hypoglycaemia: a delayed presentation of Sheehan syndrome.
    BMJ case reports, 2014, May-19, Volume: 2014

    Topics: Blood Chemical Analysis; Blood Glucose; Delayed Diagnosis; Diagnosis, Differential; Drug Therapy, Co

2014
What is your diagnosis? Liver aspirate from a hypoglycemic dog.
    Veterinary clinical pathology, 2015, Volume: 44, Issue:3

    Topics: Abdomen; Animals; Anticonvulsants; Biopsy, Fine-Needle; Dog Diseases; Dogs; Euthanasia, Animal; Hypo

2015
Severe co-trimoxazole-induced hypoglycaemia in a patient with microscopic polyangiitis.
    BMJ case reports, 2017, Mar-16, Volume: 2017

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Humans; Hypoglycemia; Male; Microscopic Polyangiiti

2017
Life-threatening hypoglycemia induced by a tyrosine kinase inhibitor in a patient with neuroendocrine tumor: a case report.
    Diabetes research and clinical practice, 2011, Volume: 93, Issue:2

    Topics: Adult; Antineoplastic Agents; Critical Care; Critical Illness; Humans; Hypoglycemia; Indoles; Male;

2011
Treatment of recurrent hypoglycemia with plasmapheresis and steroid in nondiabetic patient.
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2013, Volume: 48, Issue:1

    Topics: Adult; Humans; Hypoglycemia; Male; Plasmapheresis; Prednisolone

2013
[Hypoglycemia associated with the production of insulin-like growth factor (IGF)-II by a hemangiopericytoma].
    Deutsche medizinische Wochenschrift (1946), 2003, Feb-07, Volume: 128, Issue:6

    Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alky

2003
Severe and prolonged hypoglycemia triggered by long-acting octreotide in a patient with malignant mesenchymal tumor: case report.
    Journal of chemotherapy (Florence, Italy), 2003, Volume: 15, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Female; Glucocorticoids; Humans; Hypoglycemia; Mesoderm; Middle Age

2003
DIABETES MELLITUS PRESENTING AS SPONTANEOUS HYPOGLYCAEMIA IN CHILDHOOD.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Adolescent; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diagnosis; Glucose Tolerance Test;

1964
The effectiveness of different treatment options for non-islet cell tumour hypoglycaemia.
    Clinical endocrinology, 2004, Volume: 60, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Female; Glucocorticoids; Human Growth Horm

2004
Effect of steroid therapy for late dumping syndrome after total gastrectomy: report of a case.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:5

    Topics: Anastomosis, Roux-en-Y; Dumping Syndrome; Female; Gastrectomy; Glucocorticoids; Humans; Hypoglycemia

2004
[Non-islet cell tumor hypoglycemia].
    Duodecim; laaketieteellinen aikakauskirja, 2004, Volume: 120, Issue:22

    Topics: Aged; Aged, 80 and over; Drug Therapy, Combination; Finland; Follow-Up Studies; Glucose; Humans; Hyp

2004
Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone.
    The American journal of the medical sciences, 2005, Volume: 329, Issue:5

    Topics: Adult; Aged; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus; Female; Humans; Hyperglyce

2005
Hepatocellular carcinoma with persistent hypoglycemia: successful treatment with corticosteroid and frequent high carbohydrate intake.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2005, Volume: 88, Issue:12

    Topics: Adult; Carcinoma, Hepatocellular; Dietary Carbohydrates; Glucocorticoids; Humans; Hypoglycemia; Live

2005
Glucocorticoid therapy ameliorated hypoglycemia in insulin-like growth factor-II-producing solitary fibrous tumor.
    Internal medicine (Tokyo, Japan), 2006, Volume: 45, Issue:8

    Topics: Fibroma; Glucocorticoids; Humans; Hypoglycemia; Insulin-Like Growth Factor II; Liver Neoplasms; Male

2006
Insulinoma with early-morning abnormal behavior.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:7

    Topics: Aged; Behavior; Behavioral Symptoms; Drug Therapy, Combination; Follow-Up Studies; Glucose; Glucose

2007
A case of systemic lupus erythematosus presenting as hypoglycemia due to anti-insulin receptor antibodies.
    Rheumatology international, 2008, Volume: 29, Issue:1

    Topics: Adult; Autoantibodies; Diagnosis, Differential; Female; Glucocorticoids; Humans; Hypoglycemia; Insul

2008
Non-islet cell tumour-associated hypoglycaemia: 111In-octreotide imaging and efficacy of octreotide, growth hormone and glucocorticosteroids.
    Clinical endocrinology, 1996, Volume: 44, Issue:6

    Topics: Aged; Bendroflumethiazide; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hypoglycemia;

1996
Ovarian carcinoma producing hypoglycaemia.
    Postgraduate medical journal, 1998, Volume: 74, Issue:868

    Topics: Adult; Antineoplastic Agents, Hormonal; Carcinoma; Female; Growth Hormone; Hormones; Humans; Hypogly

1998
Isolated ACTH deficiency and pregnancy.
    Obstetrics and gynecology, 1976, Volume: 48, Issue:6

    Topics: Adrenocorticotropic Hormone; Adult; Amenorrhea; Female; Humans; Hypoglycemia; Infant, Newborn; Predn

1976
[Results in the treatment of newborns of diabetic mothers].
    Zeitschrift fur arztliche Fortbildung, 1979, Apr-01, Volume: 73, Issue:7

    Topics: Female; Humans; Hyperbilirubinemia; Hypoglycemia; Incubators, Infant; Infant Mortality; Infant, Newb

1979
Amino acid metabolism in dysmature newborn rats--possible explanation for the antihypoglycemic effect of prenatal glucocorticoids.
    Pediatric research, 1977, Volume: 11, Issue:11

    Topics: Amino Acids; Animals; Animals, Newborn; Disease Models, Animal; Female; Gluconeogenesis; Hypoglycemi

1977
A case of autoimmune insulin antibody syndrome associated with polymyositis, empty sella and apparent high urinary output of immunoreactive insulin.
    Endocrinologia japonica, 1992, Volume: 39, Issue:3

    Topics: Autoantibodies; Autoimmune Diseases; Blood Glucose; C-Peptide; Child; Empty Sella Syndrome; Glucose

1992
Hypothalamic-pituitary-adrenocortical suppression and recovery in renal transplant patients returning to maintenance dialysis.
    The Quarterly journal of medicine, 1986, Volume: 61, Issue:235

    Topics: Adolescent; Adult; Depression, Chemical; Female; Graft Rejection; Humans; Hydrocortisone; Hypoglycem

1986
[Hypoglycemia of newborn infants--therapy and prevention].
    Padiatrie und Grenzgebiete, 1987, Volume: 26, Issue:3

    Topics: Combined Modality Therapy; Glucose; Glucose Solution, Hypertonic; Humans; Hypoglycemia; Infant, Newb

1987
The effect of Bordetella pertussis vaccine on epinephrine induced hyperglycemia in rats.
    Acta allergologica, 1971, Volume: 26, Issue:6

    Topics: Animals; Blood Glucose; Drug Interactions; Epinephrine; Histamine Release; Hyperglycemia; Hypoglycem

1971
A new type of hypoglycaemia in a newborn infant.
    Diabetologia, 1973, Volume: 9, Issue:5

    Topics: Adult; Animals; Antigens; Blood Glucose; Chromatography, Gel; Cold Temperature; Cross Reactions; Fem

1973
Hypothalamo-pituitary-adrenal function in asthmatic patients receiving long-term corticosteroid therapy.
    Lancet (London, England), 1970, Oct-10, Volume: 2, Issue:7676

    Topics: Adult; Aged; Asthma; Blood Glucose; Circadian Rhythm; Female; Humans; Hydrocortisone; Hypoglycemia;

1970
Paradoxical increase of peripheral glucose utilization in a patient with insulinoma treated with prednisolone.
    Endokrinologie, 1966, Volume: 50, Issue:5

    Topics: Adenoma, Islet Cell; Blood Glucose; Glucose; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin;

1966
Effect of alternate-day, single-dose, corticosteroid therapy on pituitary-adrenal function.
    Annals of the rheumatic diseases, 1972, Volume: 31, Issue:5

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Hydroco

1972
Suppressive effect of glucocorticoid on arginine-induced growth hormone release in normal subjects.
    Steroids and lipids research, 1974, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Antigens; Arginine; Blood Glucose; Fatty Acids, Nonesterified; Growth Hormone; Hu

1974
[Functional state of the insular apparatus in children with rheumatism, treated with glucocorticoids].
    Pediatriia, 1969, Volume: 48, Issue:11

    Topics: Adolescent; Blood Glucose; Child; Child, Preschool; Female; Humans; Hypoglycemia; Insulin; Insulin S

1969
[Diagnosis and immediate therapy of the endocrine crisis].
    Der Internist, 1970, Volume: 11, Issue:2

    Topics: Adrenal Insufficiency; Diabetic Coma; Emergencies; Endocrine System Diseases; Glucose; Humans; Hydro

1970
[Disturbance of carbohydrate metabolism in the alcohol-fed rats].
    Nihon Naibunpi Gakkai zasshi, 1971, Jan-20, Volume: 46, Issue:10

    Topics: Adipose Tissue; Alanine; Animals; Blood Glucose; Carbon Isotopes; Diaphragm; Ethanol; Glucose; Gluco

1971
Prolonged obstructive jaundice. Report of a case in a neonate with meconium ileus and jejunal atresia.
    American journal of diseases of children (1960), 1968, Volume: 115, Issue:1

    Topics: Aspartate Aminotransferases; Bilirubin; Blood Glucose; Cholestasis; Humans; Hypoglycemia; Infant, Ne

1968
Corticosteroid treatment and surgery. 1. An investigation of the indications for steroid cover.
    Anaesthesia, 1969, Volume: 24, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Humans; Hydrocortisone; Hypoglycemia; Pituitary-Adrenal Fun

1969
The adrenocortical response to surgery and insulin-induced hypoglycaemia in corticosteroid-treated and normal subjects.
    The British journal of surgery, 1969, Volume: 56, Issue:3

    Topics: Adrenal Cortex Hormones; Blood Glucose; Humans; Hypoglycemia; Insulin; Prednisolone; Surgical Proced

1969