Page last updated: 2024-11-06

prednisolone and Endotoxin Shock

prednisolone has been researched along with Endotoxin Shock in 50 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Research Excerpts

ExcerptRelevanceReference
"We encountered a disseminated sporotrichosis patient with polyarthritis and progressive skin ulcers, who had been previously treated with prednisolone, tocilizmab, tacrolims, and cyclophosphamide under the diagnosis of rheumatoid arthritis in another hospital."7.78A case of disseminated sporotrichosis treated with prednisolone, immunosuppressants, and tocilizumab under the diagnosis of rheumatoid arthritis. ( Goto, D; Goto, M; Hayashi, T; Horikoshi, M; Ito, S; Matsumoto, I; Sumida, T; Takano, Y; Umeda, N; Yamaguchi, T, 2012)
" The IV injection of prednisolone sodium succinate, 10 mg/kg at 25 minutes before dosing the pigs with endotoxin resulted in a significant increase in survival time."5.27Endotoxin shock in the pig: beneficial effects of pretreatment with prednisolone sodium succinate. ( Houvenaghel, AM; Schrauwen, EM, 1984)
"We encountered a disseminated sporotrichosis patient with polyarthritis and progressive skin ulcers, who had been previously treated with prednisolone, tocilizmab, tacrolims, and cyclophosphamide under the diagnosis of rheumatoid arthritis in another hospital."3.78A case of disseminated sporotrichosis treated with prednisolone, immunosuppressants, and tocilizumab under the diagnosis of rheumatoid arthritis. ( Goto, D; Goto, M; Hayashi, T; Horikoshi, M; Ito, S; Matsumoto, I; Sumida, T; Takano, Y; Umeda, N; Yamaguchi, T, 2012)
"We investigated the effect of a novel N-benzoyl-L-phenylalanine derivative compound (JTE-607) on production of various cytokines and other immune responses in vitro and on endotoxin shock in vivo."3.70JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. ( Iwamura, H; Kakutani, M; Takeuchi, K; Waga, I; Wakitani, K, 1999)
"To evaluate the effect of certain drugs on hematologic changes, blood chemical values, and survival in endotoxin shock, anesthetized ponies were given (IV) endotoxin (Escherichia coli O55:B5) and then treated as follows: Group A ponies--given a saline infusion at 5 minutes and at 3 hours after they were given endotoxin; group B ponies--given flunixin meglumine at 5 minutes and at 3, 6, 9, and 24 hours after they were given endotoxin; group C ponies--treated with dexamethasone; and group D ponies--treated with prednisolone at 5 minutes and at 3, 9, and 24 hours after they were given endotoxin."3.67Endotoxin-induced hematologic and blood chemical changes in ponies: effects of flunixin meglumine, dexamethasone, and prednisolone. ( Bottoms, GD; Ewert, KM; Fessler, JF; Johnson, MA; Latshaw, HS; Templeton, CB, 1985)
"The terms corticosteroids, sepsis, septic shock, hydrocortisone, controlled trials, and randomized controlled trial were searched alone or in combination."2.61Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis. ( Fang, F; Faramand, A; He, J; Li, T; Lunsford, LD; Tang, J; Tang, R; Xu, J; Xu, P; You, C; Zhang, Y, 2019)
" Heterogeneity was related in part to the dosing strategy."2.52Corticosteroids for treating sepsis. ( Annane, D; Bellissant, E; Bollaert, PE; Briegel, J; Keh, D; Kupfer, Y, 2015)
"Most patients were on corticosteroid treatment."2.43Necrotizing fasciitis in rheumatic diseases. ( Chan, TM; Lau, CS; Mok, MY; Tang, WM; Wong, SY; Wong, WS, 2006)
"In the septic shock model, all three drugs given preventively markedly decreased circulating levels of TNF-alpha and mortality (50% mortality in fluoxetine treated group, 30% in desipramine and prednisolone treated groups versus 90% in controls)."1.34Anti-inflammatory properties of desipramine and fluoxetine. ( Bichon, F; Detoc, M; Henriquet, C; Jaffuel, D; Mathieu, M; Michel, A; Portet, K; Roumestan, C, 2007)
"We have developed a septic shock model in mice by sequential administration of beta-glucan, a biological response modifier, and indomethacin (IND), a nonsteroidal anti-inflammatory drug."1.34Lincomycin protects mice from septic shock in beta-glucan-indomethacin model. ( Adachi, Y; Miura, NN; Nameda, S; Ohno, N, 2007)
"Septic shock is characterised by infection causing a systemic inflammatory response, end-organ failure and acute circulatory collapse."1.30Sweet's syndrome associated with systemic inflammatory response syndrome. ( Matthews, PC; Willatts, SM, 1998)
" The IV injection of prednisolone sodium succinate, 10 mg/kg at 25 minutes before dosing the pigs with endotoxin resulted in a significant increase in survival time."1.27Endotoxin shock in the pig: beneficial effects of pretreatment with prednisolone sodium succinate. ( Houvenaghel, AM; Schrauwen, EM, 1984)
" This lack of effect can be due to an inappropriate dosage of the steroid or failure of steroid treatment to alleviate endotoxin-mediated effects."1.27Endotoxic shock in the awake young pig: absence of beneficial effect of prednisolone sodium succinate treatment. ( Houvenaghel, AM; Schrauwen, EM, 1985)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-199035 (70.00)18.7374
1990's2 (4.00)18.2507
2000's8 (16.00)29.6817
2010's5 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fang, F1
Zhang, Y1
Tang, J1
Lunsford, LD1
Li, T1
Tang, R1
He, J1
Xu, P1
Faramand, A1
Xu, J1
You, C1
Jamieson, A1
Parkins, G1
White, B1
Annane, D2
Bellissant, E1
Bollaert, PE1
Briegel, J1
Keh, D1
Kupfer, Y1
Wyska, E1
Yamaguchi, T1
Ito, S1
Takano, Y1
Umeda, N1
Goto, M1
Horikoshi, M1
Hayashi, T1
Goto, D1
Matsumoto, I1
Sumida, T1
MURANAKA, M1
ABE, K1
HAZEYAMA, S1
KURAJIMA, S1
SAMBHI, MP1
WEIL, MH1
UDHOJI, VN1
SHUBIN, H1
Iwamura, H2
Sato, M1
Wakitani, K2
Kotanidou, AN1
Zakynthinos, E1
Andrianakis, I1
Zervakis, D1
Kokotsakis, I1
Argyrakos, T1
Argiropoulou, A1
Margariti, G1
Douzinas, E1
Mok, MY1
Wong, SY1
Chan, TM1
Tang, WM1
Wong, WS1
Lau, CS1
Amano, T1
Nishihira, J1
Miki, I1
Roumestan, C1
Michel, A1
Bichon, F1
Portet, K1
Detoc, M1
Henriquet, C1
Jaffuel, D1
Mathieu, M1
Nameda, S1
Miura, NN1
Adachi, Y1
Ohno, N1
Renaud, S1
Allard, C1
Latour, JG1
Sekigawa, T1
Schrauwen, EM2
Houvenaghel, AM2
Brückner, O1
Kresse, M1
Neubert, V1
Triest, H1
Trautmann, M1
Roland, DA1
Mora, EC1
Hoerr, FJ1
White, GL1
White, GS1
Richter, K1
Bowen, JM1
Matthews, PC1
Willatts, SM1
Kakutani, M1
Takeuchi, K1
Waga, I1
Emerson, TE1
Katsu, M1
Mita, S1
Soma, T1
Adachi, M1
Hankes, GH1
Templeton, CB2
Bottoms, GD2
Fessler, JF2
Ewert, KM2
Roesel, OF1
Johnson, MA2
Latshaw, HS2
Bahrami, S1
Schiesser, A1
Redl, H1
Schlag, G1
Ho, CH1
Chiang, YM1
Chong, LL1
Lin, HY1
Hwang, TS1
Wittels, W1
Bartel, J3
Bornemann, K1
Schulz, E1
Heinecker, R1
Martin, L1
Anton, AH1
Huth, K1
Missler, U1
Schmahl, FW1
Beickert, A1
Mills, LC1
Jaques, R1
Jaquet, H1
Vaughn, D1
Kirschbaum, TH1
Bersentes, T1
Assali, NS1
Luger, A1
Pavlik, F1
Dieckhoff, J2
Gawellek, F1
Iwanoff, S1
Hoppe, E1
Schimpf, K1
Krecke, HJ1
Herbig, W1
Sullivan, TJ1
Cavanagh, D1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159]Phase 2140 participants (Actual)Interventional2018-02-05Completed
Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock: a Randomized Clinical Study (VITAMIN TRIAL)[NCT05192213]Phase 31,090 participants (Anticipated)Interventional2021-08-01Recruiting
Fluoxetine to Reduce Hospitalization From COVID-19 Infection (FloR COVID-19)[NCT04570449]Early Phase 10 participants (Actual)Interventional2020-11-30Withdrawn (stopped due to Study timeline is not feasible)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Sequential Organ Failure Assessment (SOFA) Score

Defined as the day 4 post-randomization SOFA score minus the initial SOFA score. The Sequential Organ Failure Assessment (SOFA) Score is a mortality prediction score that is based on the degree of dysfunction of six organ systems. The score is calculated on admission and every 24 hours until discharge using the worst parameters measured during the prior 24 hours SOFA score ranges from 0 (no organ dysfunction) to 24 (highest possible score / organ dysfunction). (NCT03422159)
Timeframe: 4 days post-randomization

Interventionscore on a scale (Mean)
Treatment Arm2.9
Placebo Arm1.93

Hospital Length of Stay

Time from admitting to discharge of hospital stay. (NCT03422159)
Timeframe: From admission to the hospital until final discharge, up to 28 days.

InterventionDays (Mean)
Treatment Arm11.5
Placebo Arm11

Hospital Mortality

In-hospital mortality rate. (NCT03422159)
Timeframe: Survival until hospital discharge, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm11
Placebo Arm13

ICU Length of Stay

Time from admitting to ICU to discharge. (NCT03422159)
Timeframe: From admission to the ICU until final discharge from the ICU, up to an average of 7 days.

Interventiondays (Mean)
Treatment Arm4.76
Placebo Arm4.66

ICU Mortality

ICU mortality rate (NCT03422159)
Timeframe: From admission to hospital until final discharge from the ICU, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm6
Placebo Arm10

Procalcitonin (PCT) Clearance

PCT at 96 hours minus initial PCT, divided by the initial PCT multiplied by 100. (NCT03422159)
Timeframe: 4 days post-randomization

InterventionPercent (Mean)
Treatment Arm63
Placebo Arm58

Time to Vasopressor Independence (Hours)

Defined as the time from starting the active treatment/placebo to discontinuation of all pressors. (NCT03422159)
Timeframe: From start of vasopressor medication to final discontinuation of vasopressor medication, up to 7 days.

Interventionhours (Mean)
HAT Treatment27
Comparator53

Ventilator Free Days

Number of days alive and off of the ventilator at day 28. (NCT03422159)
Timeframe: 28 Days post-randomization

InterventionDays (Mean)
Treatment Arm22
Placebo Arm22.4

Reviews

7 reviews available for prednisolone and Endotoxin Shock

ArticleYear
Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis.
    JAMA internal medicine, 2019, 02-01, Volume: 179, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Glucocorticoids; Humans; Hydrocortisone; Intensive Care Units; Organ

2019
Corticosteroids for treating sepsis.
    The Cochrane database of systematic reviews, 2015, Dec-03, Issue:12

    Topics: Adrenal Cortex Hormones; Adult; Child; Critical Care; Dexamethasone; Fludrocortisone; Humans; Hydroc

2015
Corticosteroids for treating sepsis.
    The Cochrane database of systematic reviews, 2015, Dec-03, Issue:12

    Topics: Adrenal Cortex Hormones; Adult; Child; Critical Care; Dexamethasone; Fludrocortisone; Humans; Hydroc

2015
Corticosteroids for treating sepsis.
    The Cochrane database of systematic reviews, 2015, Dec-03, Issue:12

    Topics: Adrenal Cortex Hormones; Adult; Child; Critical Care; Dexamethasone; Fludrocortisone; Humans; Hydroc

2015
Corticosteroids for treating sepsis.
    The Cochrane database of systematic reviews, 2015, Dec-03, Issue:12

    Topics: Adrenal Cortex Hormones; Adult; Child; Critical Care; Dexamethasone; Fludrocortisone; Humans; Hydroc

2015
Aspergillus endocarditis in a native valve after amphotericin B treatment.
    The Annals of thoracic surgery, 2004, Volume: 78, Issue:4

    Topics: Amphotericin B; Anti-Infective Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Drug Resis

2004
Necrotizing fasciitis in rheumatic diseases.
    Lupus, 2006, Volume: 15, Issue:6

    Topics: Adult; Aeromonas; Animals; Anti-Bacterial Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Arth

2006
Therapy of shock: the corticosteroid question.
    The Veterinary clinics of North America, 1976, Volume: 6, Issue:2

    Topics: Adrenal Cortex Hormones; Animals; Cardiac Output; Cell Membrane; Dexamethasone; Dog Diseases; Dogs;

1976
[Pathogenesis of the septic-toxic shock].
    Zeitschrift fur arztliche Fortbildung, 1972, Aug-01, Volume: 66, Issue:15

    Topics: Animals; Autolysis; Capillary Permeability; Cardiac Output; Cathepsins; Disseminated Intravascular C

1972
[Glucocorticoids in prophylaxis and therapy of different kinds of shock].
    Das Deutsche Gesundheitswesen, 1970, Oct-29, Volume: 25, Issue:44

    Topics: Anaphylaxis; Anti-Bacterial Agents; Cardiac Glycosides; Dexamethasone; Dextrans; Epinephrine; Glucoc

1970

Other Studies

43 other studies available for prednisolone and Endotoxin Shock

ArticleYear
Drugs, the Thyroid, and the Heart: A Lethal Cocktail.
    The American journal of medicine, 2019, Volume: 132, Issue:3

    Topics: Agranulocytosis; Amiodarone; Anti-Arrhythmia Agents; Antithyroid Agents; Atrial Fibrillation; Carbim

2019
DRESS syndrome presenting like septic shock.
    QJM : monthly journal of the Association of Physicians, 2013, Volume: 106, Issue:7

    Topics: Adult; Diagnosis, Differential; Drug Eruptions; Drug Hypersensitivity Syndrome; Drug-Related Side Ef

2013
Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock.
    International immunopharmacology, 2009, Volume: 9, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytokine

2009
A case of disseminated sporotrichosis treated with prednisolone, immunosuppressants, and tocilizumab under the diagnosis of rheumatoid arthritis.
    Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:15

    Topics: Aged; Antibodies, Monoclonal, Humanized; Arthritis, Infectious; Arthritis, Rheumatoid; Diagnosis, Di

2012
[SHOCK-LIKE SYMPTOMS CAUSED BY DRUGS AND THEIR TREATMENT. (2) CLINICAL ASPECTS].
    Jibi inkoka Otolaryngology, 1963, Volume: 35

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Blood Chemical Analysis; Body Constitut

1963
[CASE OF SYMPTOMS OF SHOCK MANIFESTED AFTER EAR IRRIGATION WITH COLISTIN AND PREDONINE].
    Jibi inkoka Otolaryngology, 1963, Volume: 35

    Topics: Colistin; Drug Hypersensitivity; Otitis Media; Prednisolone; Shock; Shock, Septic; Therapeutic Irrig

1963
ADRENOCORTICOIDS IN THE MANAGEMENT OF SHOCK.
    International anesthesiology clinics, 1964, Volume: 2

    Topics: Adrenal Cortex Hormones; Aldosterone; Blood Circulation; Dexamethasone; Endotoxins; Humans; Hypotens

1964
Comparative study of glucocorticoids, cyclosporine A, and JTE-607 [(-)-Ethyl-N[3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl]-L-phenylalaninate dihydrochloride] in a mouse septic shock model.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cyclosporine; Cytokines; Enzyme-Lin

2004
Blockade of macrophage migration inhibitory factor (MIF) prevents the antigen-induced response in a murine model of allergic airway inflammation.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2007, Volume: 56, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antibodies, Blocking; Asthma; Bronchial Hyperreactivity; Bronchoa

2007
Anti-inflammatory properties of desipramine and fluoxetine.
    Respiratory research, 2007, May-03, Volume: 8

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Asthma; Cells, Cultured; Cytokines; Desipr

2007
Lincomycin protects mice from septic shock in beta-glucan-indomethacin model.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; beta-Glucans; Blood Glucose

2007
Prohormones: novel biomarkers for corticosteroids in septic shock?
    Intensive care medicine, 2008, Volume: 34, Issue:3

    Topics: Adrenomedullin; Atrial Natriuretic Factor; Biomarkers; Endotoxemia; Glucocorticoids; Hormones; Human

2008
The prevention by glucocorticoids of endotoxin-initiated thrombosis in rat, in relation to fibrinolysis, coagulation, and lipemia.
    American heart journal, 1966, Volume: 72, Issue:6

    Topics: Adrenal Cortex Hormones; Animals; Blood Coagulation; Budd-Chiari Syndrome; Fibrinolysis; Humans; Hyd

1966
[Biochemical aspects of endotoxicosis in rat: lipid peroxide formation and the effect of free radical scavengers].
    Bulletin of the Chest Disease Research Institute, Kyoto University, 1984, Volume: 17, Issue:1-2

    Topics: Animals; Endotoxins; Escherichia coli; Glutathione; Lipid Peroxides; Liver; Lung; Male; Prednisolone

1984
Endotoxin shock in the pig: beneficial effects of pretreatment with prednisolone sodium succinate.
    American journal of veterinary research, 1984, Volume: 45, Issue:8

    Topics: Animals; Cardiovascular System; Female; Prednisolone; Shock, Septic; Swine; Swine Diseases; Time Fac

1984
[Toxic shock syndrome].
    Immunitat und Infektion, 1983, Volume: 11, Issue:3

    Topics: Adult; Female; Humans; Menstrual Hygiene Products; Prednisolone; Shock, Septic; Staphylococcus aureu

1983
Toxic shock-like syndrome in hens and its relationship to shell-less eggs.
    Poultry science, 1984, Volume: 63, Issue:4

    Topics: Animals; Calcification, Physiologic; Chickens; Cyclophosphamide; Disease Models, Animal; Egg Shell;

1984
In vitro effects of prednisolone sodium succinate and Escherichia coli organisms on neutrophil survival, glucose utilization, and E coli clearance in canine blood.
    American journal of veterinary research, 1982, Volume: 43, Issue:6

    Topics: Animals; Blood Glucose; Cell Survival; Dogs; Endotoxins; Escherichia coli; Escherichia coli Infectio

1982
[Children's emergencies--what to do?].
    Fortschritte der Medizin, 1982, Jul-22, Volume: 100, Issue:27-28

    Topics: Abdomen, Acute; Aerosols; Child, Preschool; Chloral Hydrate; Cold Temperature; Coma; Croup; Diazepam

1982
Are corticosteroids useful in shock therapy?
    Journal of the American Veterinary Medical Association, 1980, Sep-01, Volume: 177, Issue:5

    Topics: Adrenal Cortex Hormones; Animals; Animals, Domestic; Anti-Bacterial Agents; Dexamethasone; Hydrocort

1980
Sweet's syndrome associated with systemic inflammatory response syndrome.
    Intensive care medicine, 1998, Volume: 24, Issue:10

    Topics: Anti-Inflammatory Agents; Female; Humans; Middle Aged; Prednisolone; Pyelonephritis; Shock, Septic;

1998
JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Genes, MHC Cl

1999
Total and regional cerebral hemodynamic and metabolic abnormalities during endotoxin shock: prevention with methylprednisolone.
    Advances in neurology, 1978, Volume: 20

    Topics: Animals; Brain; Carbon Dioxide; Cerebrovascular Circulation; Dogs; Escherichia coli Infections; Fema

1978
[Steroid therapy for infectious diseases--indications and methods of administration].
    Nihon rinsho. Japanese journal of clinical medicine, 1979, Jun-10, Volume: 37, Issue:6

    Topics: Adult; Female; Glucocorticoids; Humans; Klebsiella Infections; Male; Prednisolone; Shock, Septic

1979
[Recommendations for the prevention and treatment of transfusion reactions].
    Blut, 1976, Volume: 32, Issue:2

    Topics: Antibody Formation; Blood; Blood Circulation Time; Diuretics; Embolism, Air; Hemolysis; Heparin; Hum

1976
Endotoxin-induced hemodynamic and prostaglandin changes in ponies: effects of flunixin meglumine, dexamethasone, and prednisolone.
    Circulatory shock, 1987, Volume: 23, Issue:4

    Topics: Animals; Clonixin; Dexamethasone; Endotoxins; Epoprostenol; Escherichia coli; Female; Hemodynamics;

1987
Comparison of different corticosteroids in rat endotoxemia.
    Progress in clinical and biological research, 1987, Volume: 236B

    Topics: Adrenal Cortex Hormones; Animals; Dexamethasone; Disease Models, Animal; Endotoxins; Male; Methylpre

1987
Development of chronic lymphocytic leukaemia in a case of Sjögren's syndrome with systemic lupus erythematosus.
    Scandinavian journal of haematology, 1985, Volume: 35, Issue:2

    Topics: Aged; B-Lymphocytes; Cephalosporins; Female; Gentamicins; Humans; Leukemia, Lymphoid; Lupus Erythema

1985
Endotoxin-induced hematologic and blood chemical changes in ponies: effects of flunixin meglumine, dexamethasone, and prednisolone.
    American journal of veterinary research, 1985, Volume: 46, Issue:1

    Topics: Animals; Blood Cell Count; Blood Chemical Analysis; Blood Coagulation Tests; Blood Gas Analysis; Clo

1985
Endotoxic shock in the awake young pig: absence of beneficial effect of prednisolone sodium succinate treatment.
    American journal of veterinary research, 1985, Volume: 46, Issue:8

    Topics: Animals; Body Temperature; Electrocardiography; Escherichia coli; Female; Hemodynamics; Hydrogen-Ion

1985
[Antibiotics and corticosteroids in the corticosteroids in the treatment of burns].
    Wiener klinische Wochenschrift, 1971, Dec-31, Volume: 83, Issue:52

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Burns; Chloramphenicol; Dexamethasone; Gentamicins;

1971
[Acute, non-allergic reactions following i.m. administration of clemizole-penicillin G and streptomycin].
    Munchener medizinische Wochenschrift (1950), 1966, Apr-15, Volume: 108, Issue:15

    Topics: Adult; Anaphylaxis; Benzimidazoles; Diagnosis, Differential; Drug Hypersensitivity; Female; Histamin

1966
Toxicity of acids and bases after intraperitoneal injection.
    European journal of pharmacology, 1970, Jul-01, Volume: 11, Issue:1

    Topics: Acetates; Acids; Alkalies; Analgesics; Anesthetics, Local; Animals; Anti-Bacterial Agents; Body Temp

1970
[Influences of prednisolone on changes in lipid metabolism following endotoxin].
    Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa, 1972, Volume: 12

    Topics: Animals; Cholesterol; Endotoxins; Fatty Acids, Nonesterified; Injections, Intravenous; Lipid Metabol

1972
Corticosteroids in endotoxic shock.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1971, Volume: 138, Issue:2

    Topics: Adrenal Cortex Hormones; Animals; Dexamethasone; Endotoxins; Escherichia coli; Hydrocortisone; Letha

1971
[What is your diagnosis?].
    Medizinische Klinik, 1971, Nov-05, Volume: 66, Issue:45

    Topics: Adult; Amputation, Surgical; Blood Transfusion; Chloramphenicol; Female; Forearm Injuries; Fractures

1971
The duration of action of certain corticosteroids in the acutely adrenalectomized rat as estimated by reference to their protective effect in endotoxin shock.
    Experientia, 1964, Apr-15, Volume: 20, Issue:4

    Topics: Adrenalectomy; Animals; Endotoxins; Hydrocortisone; Mortality; Prednisolone; Rats; Serratia marcesce

1964
Effects of corticosteroid hormones on regional circulation in endotoxin shock.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 124, Issue:3

    Topics: Acid-Base Equilibrium; Acidosis; Aldosterone; Animals; Blood Circulation; Blood Flow Velocity; Blood

1967
[Effect of corticosteroids on the Jarisch-Herxheimer reaction].
    Wiener klinische Wochenschrift, 1971, Mar-26, Volume: 83, Issue:12

    Topics: Depression, Chemical; Fever; Humans; Neurosyphilis; Penicillins; Prednisolone; Procaine; Shock, Sept

1971
[The effect of prednisolone and redergam on experimental endotoxin shock].
    Das Deutsche Gesundheitswesen, 1967, Jan-05, Volume: 22, Issue:1

    Topics: Animals; Catecholamines; Male; Prednisolone; Rabbits; Reserpine; Shock, Septic

1967
[Therapy of experimental endotoxin shock. II. Morphologic changes in kidneys and adrenals in endotoxin shock under treatment with prednisolone and redergam].
    Padiatrie und Grenzgebiete, 1968, Volume: 7, Issue:2

    Topics: Adrenal Glands; Animals; Humans; Kidney; Male; Prednisolone; Rabbits; Shock, Septic; Shwartzman Phen

1968
[Contrast media-induced shock. Successful therapy using streptokinase].
    Deutsche medizinische Wochenschrift (1946), 1969, Feb-21, Volume: 94, Issue:8

    Topics: Adult; Blood Pressure; Contrast Media; Female; Fibrinolysis; Humans; Norepinephrine; Plasma Substitu

1969
Corticosteroids in endotoxin shock. Effect on renal vasomotion.
    Archives of surgery (Chicago, Ill. : 1960), 1966, Volume: 92, Issue:5

    Topics: Animals; Blood Pressure; Dexamethasone; Dogs; Endotoxins; Kidney; Prednisolone; Shock, Septic; Vasom

1966