prednisolone has been researched along with Diathesis in 28 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with SAH given prednisolone are at greater risk for developing serious infections and infections after treatment than patients not given prednisolone, which may offset its therapeutic benefit." | 9.24 | In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA. ( Allison, M; Atkinson, SR; Austin, A; Forrest, EH; Gleeson, D; Knapp, S; Masson, S; Maurice, J; McCune, A; Patch, D; Richardson, P; Ryder, SD; Thursz, MR; Vergis, N; Wright, M, 2017) |
| "Patients with SAH given prednisolone are at greater risk for developing serious infections and infections after treatment than patients not given prednisolone, which may offset its therapeutic benefit." | 5.24 | In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA. ( Allison, M; Atkinson, SR; Austin, A; Forrest, EH; Gleeson, D; Knapp, S; Masson, S; Maurice, J; McCune, A; Patch, D; Richardson, P; Ryder, SD; Thursz, MR; Vergis, N; Wright, M, 2017) |
| "In the Steroids for Corneal Ulcers Trial (SCUT), 500 corneal infections were treated with topical moxifloxacin." | 5.17 | Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis. ( Acharya, NR; Bharathi, MJ; Glidden, DV; Lalitha, P; Lietman, TM; Manikandan, P; Mascarenhas, J; Nardone, N; Oldenburg, CE; Rajaraman, R; Ravindran, M; Ray, KJ; Srinivasan, M, 2013) |
| "Relapse was relatively common among all subgroups." | 1.51 | Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol. ( Alayari, A; Eliyan, Y; Heesch, J; Hussain, SA; Rajaraman, RR; Sankar, R, 2019) |
| " All six patients received prophylactic cranial irradiation with a dosage of 18 or 24 Gy." | 1.34 | Moyamoya syndrome following childhood acute lymphoblastic leukemia. ( Hanada, R; Ikuta, K; Ishimoto, K; Kaneko, T; Kikuchi, A; Maeda, M; Okimoto, Y; Tsuchida, M, 2007) |
| "Patients with systemic lupus erythematosus are prone to various infections, often associated with high mortality." | 1.33 | CAPD-related peritonitis due to Salmonella enteritidis in a patient with SLE. ( Chiu, YL; Chu, TS; Hsueh, PR; Huang, JW; Wu, KD, 2005) |
| "No increased frequency of infection was seen for the children with genotypes encoding serum low levels of MBL." | 1.33 | Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiency. ( Andreassen, B; Garred, P; Lausen, B; Madsen, HO; Schmiegelow, K, 2006) |
| " Prednisone, begun perioperatively, was reduced gradually from a mean initial dosage of 38." | 1.32 | [Pneumocystis carinii pneumonia complicating brain tumor]. ( Gejyo, F; Nishibori, T; Takahashi, H; Tanaka, R; Tsukada, H; Uzuka, T, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.29) | 18.7374 |
| 1990's | 9 (32.14) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Vuille-Lessard, É | 1 |
| Montani, M | 1 |
| Bosch, J | 1 |
| Semmo, N | 1 |
| Wu, YT | 1 |
| Truong, TN | 1 |
| Tam, C | 1 |
| Mendoza, MN | 1 |
| Zhu, L | 1 |
| Evans, DJ | 1 |
| Fleiszig, SMJ | 1 |
| Matsumoto, T | 1 |
| Fujita, M | 1 |
| Hirano, R | 1 |
| Sasaki, T | 1 |
| Watanabe, K | 1 |
| Eliyan, Y | 1 |
| Heesch, J | 1 |
| Alayari, A | 1 |
| Rajaraman, RR | 1 |
| Sankar, R | 1 |
| Hussain, SA | 1 |
| Kanazawa, H | 1 |
| Kotoda, A | 1 |
| Akimoto, T | 1 |
| Shinozaki, T | 1 |
| Inoue, M | 1 |
| Sugimoto, H | 1 |
| Kusano, E | 1 |
| Vergis, N | 1 |
| Atkinson, SR | 1 |
| Knapp, S | 1 |
| Maurice, J | 1 |
| Allison, M | 1 |
| Austin, A | 1 |
| Forrest, EH | 1 |
| Masson, S | 1 |
| McCune, A | 1 |
| Patch, D | 1 |
| Richardson, P | 1 |
| Gleeson, D | 1 |
| Ryder, SD | 1 |
| Wright, M | 1 |
| Thursz, MR | 1 |
| Oldenburg, CE | 1 |
| Lalitha, P | 1 |
| Srinivasan, M | 2 |
| Manikandan, P | 1 |
| Bharathi, MJ | 1 |
| Rajaraman, R | 1 |
| Ravindran, M | 1 |
| Mascarenhas, J | 1 |
| Nardone, N | 1 |
| Ray, KJ | 1 |
| Glidden, DV | 1 |
| Acharya, NR | 2 |
| Lietman, TM | 2 |
| Uzuka, T | 1 |
| Takahashi, H | 1 |
| Tanaka, R | 1 |
| Nishibori, T | 1 |
| Tsukada, H | 1 |
| Gejyo, F | 1 |
| Chiu, YL | 1 |
| Huang, JW | 1 |
| Hsueh, PR | 1 |
| Wu, KD | 1 |
| Chu, TS | 1 |
| Lausen, B | 1 |
| Schmiegelow, K | 1 |
| Andreassen, B | 1 |
| Madsen, HO | 1 |
| Garred, P | 1 |
| Kikuchi, A | 1 |
| Maeda, M | 1 |
| Hanada, R | 1 |
| Okimoto, Y | 1 |
| Ishimoto, K | 1 |
| Kaneko, T | 1 |
| Ikuta, K | 1 |
| Tsuchida, M | 1 |
| Balighi, K | 1 |
| Robati, RM | 1 |
| Hejazi, N | 1 |
| Chen, A | 1 |
| Prajna, L | 1 |
| Mahalakshmi, R | 1 |
| Whitcher, JP | 1 |
| McLeod, S | 1 |
| Hanna, PE | 1 |
| Percy, DH | 1 |
| Paturzo, F | 1 |
| Bhatt, PN | 1 |
| Kaufman, J | 1 |
| Grønstøl, H | 1 |
| Hebart, H | 1 |
| Ehninger, G | 1 |
| Schmidt, H | 1 |
| Berner, B | 1 |
| Reuss-Borst, M | 1 |
| Waller, HD | 1 |
| Müller, CA | 1 |
| Einsele, H | 1 |
| Rice, P | 1 |
| Simmons, K | 1 |
| Carr, R | 1 |
| Banatvala, J | 1 |
| De Lord, C | 1 |
| Marsh, JC | 1 |
| Smith, JG | 1 |
| Singer, CR | 1 |
| Gordon-Smith, EC | 1 |
| Lee, SH | 1 |
| Park, SK | 1 |
| Seo, M | 1 |
| Guk, SM | 1 |
| Choi, MH | 1 |
| Chai, JY | 1 |
| Nomura, S | 1 |
| Matsuzaki, T | 1 |
| Ozaki, Y | 1 |
| Yamaoka, M | 1 |
| Yoshimura, C | 1 |
| Katsura, K | 1 |
| Xie, GL | 1 |
| Kagawa, H | 1 |
| Ishida, T | 1 |
| Fukuhara, S | 1 |
| Gumà, J | 1 |
| Rubió, J | 1 |
| Masip, C | 1 |
| Alvaro, T | 1 |
| Borràs, JL | 1 |
| Czerwony, G | 1 |
| Alten, R | 1 |
| Gromnica-Ihle, E | 1 |
| Hagemann, D | 1 |
| Reuter, U | 1 |
| Sörensen, H | 1 |
| Müller, B | 1 |
| Ide, S | 1 |
| Koga, T | 1 |
| Rikimaru, T | 1 |
| Katsuki, Y | 1 |
| Oizumi, K | 1 |
| Eguchi, K | 1 |
| Mazzette, R | 1 |
| Sanna, E | 1 |
| De Santis, EP | 1 |
| Pisanu, S | 1 |
| Leoni, A | 1 |
| Tebbe, B | 1 |
| Mayer-da-Silva, A | 1 |
| Garbe, C | 1 |
| von Keyserlingk, HJ | 1 |
| Orfanos, CE | 1 |
| Das, M | 1 |
| Agrawal, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Steroids for Corneal Ulcers Trial[NCT00324168] | Phase 4 | 500 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
LogMAR (logarithm of the Minimum Angle of Resolution) is a measure of visual acuity in which the smaller values indicate better visual acuity. (NCT00324168)
Timeframe: 3 months from enrollment
| Intervention | logMAR (Mean) |
|---|---|
| Steroid | 0.42 |
| Placebo | 0.41 |
LogMAR (logarithm of the Minimum Angle of Resolution) is a measure of visual acuity in which the smaller values indicate better visual acuity. (NCT00324168)
Timeframe: 12 months from enrollment
| Intervention | logMAR (Mean) |
|---|---|
| Steroid | 2.90 |
| Placebo | 2.87 |
LogMAR (logarithm of the Minimum Angle of Resolution) is a measure of visual acuity in which the smaller values indicate better visual acuity. (NCT00324168)
Timeframe: 3 months from enrollment
| Intervention | logMAR (Mean) |
|---|---|
| Steroid | 0.48 |
| Placebo | 0.49 |
Best spectacle-corrected visual acuity (BSCVA) for this outcome is measured in logMAR (logarithm of the Minimum Angle of Resolution) in which smaller values indicate better visual acuity. Minimum inhibitory concentration (MIC) to moxifloxacin was measured by E test and a log2-transformation of MIC was used in all analyses. In this analysis we add MIC to the model examining BSCVA at 3 months. (NCT00324168)
Timeframe: 3 months after enrollment
| Intervention | logMAR (Mean) |
|---|---|
| Steroid | 0.50 |
| Placebo | 0.46 |
(NCT00324168)
Timeframe: 3 months from enrollment
| Intervention | mm (Mean) |
|---|---|
| Steroid | 3.07 |
| Placebo | 3.02 |
(NCT00324168)
Timeframe: At the time of perforation
| Intervention | participants (Number) |
|---|---|
| Steroid | 7 |
| Placebo | 8 |
This outcome measured time from enrollment to resolution of the epithelial defect in days for up to 21 days. For three weeks patients were examined every 3 days for size of epithelial defect until the defect was gone. (NCT00324168)
Timeframe: From enrollment up to 21 days
| Intervention | days (Mean) |
|---|---|
| Steroid | 9.77 |
| Placebo | 9.43 |
BSCVA measured in logMAR will be examined by categories infiltrate depth (categorized by depth percentage) by mean and standard deviation as well as in a regression model. (NCT00324168)
Timeframe: 3 months from enrollment
| Intervention | logMAR (Mean) | ||
|---|---|---|---|
| >0-33% | >33%-67% | >67%-100% | |
| Placebo | 0.26 | 0.47 | 0.86 |
| Steroid | 0.35 | 0.52 | 0.80 |
BSCVA measured in logMAR will be estimated by causative organism (either Nocardia spp, Streptococcus pneumoniae, Moraxella spp, or Pseudomonas aeruginosa). BSCVA will be examined for each causative organism by mean and standard deviation as well as in a regression model. (NCT00324168)
Timeframe: 3 months after enrollment
| Intervention | logMAR (Mean) | |||
|---|---|---|---|---|
| Nocardia spp | Streptococcus pneumoniae | Moraxella spp | Pseudomonas aeruginosa | |
| Placebo | 0.36 | 0.52 | 0.26 | 0.45 |
| Steroid | 0.54 | 0.49 | 0.46 | 0.53 |
Best spectacle-corrected visual acuity (BSCVA) for this subgroup analysis was measured in logMAR and then categorized by equivalent Snellen fractions (NCT00324168)
Timeframe: 3 months from enrollment
| Intervention | logMAR (Mean) | ||
|---|---|---|---|
| <20/40 | 20/40 to 20/800 | Counting fingers (CF) or worse | |
| Placebo | -0.02 | 0.38 | 1.15 |
| Steroid | 0.06 | 0.36 | 1.00 |
Best-spectacle visual acuity (BSCVA) at 3 months from enrollment is stratified by categories of infiltrate/scar size and examined by treatment arm (NCT00324168)
Timeframe: 3 months from enrollment
| Intervention | logMAR (Mean) | |||
|---|---|---|---|---|
| 0-1.90 mm | 1.91-2.70 mm | 2.71-4.06 mm | 4.07-8.90 mm | |
| Placebo | 0.19 | 0.29 | 0.53 | 0.96 |
| Steroid | 0.18 | 0.39 | 0.53 | 0.85 |
2 reviews available for prednisolone and Diathesis
| Article | Year |
|---|---|
Diseases of the adrenal cortex of dogs and cats.
Topics: Adrenocorticotropic Hormone; Animals; Cat Diseases; Cats; Cushing Syndrome; Dexamethasone; Disease S | 1984 |
Aggressive bowel lymphoma in a patient with intestinal lymphangiectasia and widespread viral warts.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Disease Susceptibility; Dox | 1998 |
4 trials available for prednisolone and Diathesis
| Article | Year |
|---|---|
In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA.
Topics: Adult; Anti-Bacterial Agents; Disease Susceptibility; DNA, Bacterial; Double-Blind Method; Female; F | 2017 |
Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis.
Topics: Administration, Topical; Anti-Infective Agents; Aza Compounds; Bacteria; Corneal Ulcer; Disease Susc | 2013 |
Does in vitro susceptibility predict clinical outcome in bacterial keratitis?
Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Corneal Ulcer; Disease Susceptibility; Eye Infection | 2008 |
Treatment of steroid-resistant graft-versus-host disease after allogeneic bone marrow transplantation with anti-CD3/TCR monoclonal antibodies.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; | 1995 |
22 other studies available for prednisolone and Diathesis
| Article | Year |
|---|---|
Autoimmune hepatitis triggered by SARS-CoV-2 vaccination.
Topics: 2019-nCoV Vaccine mRNA-1273; Aged; Autoantibodies; Azathioprine; Carcinoma, Transitional Cell; Causa | 2021 |
Impact of topical corticosteroid pretreatment on susceptibility of the injured murine cornea to Pseudomonas aeruginosa colonization and infection.
Topics: Administration, Ophthalmic; Animals; Cornea; Corneal Injuries; Corneal Ulcer; Disease Models, Animal | 2019 |
Risk factors for pneumocystis pneumonia onset in HIV-negative patients treated with high-dose systemic corticosteroids.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Blood Proteins; Disease Susceptibility; Dose-Resp | 2019 |
Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Clinical Protocols; Cohort Studies; Disease Susceptibi | 2019 |
Serial Tc-99m MAG3 renography evaluating the recovery of acute kidney injury associated with minimal change nephrotic syndrome.
Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Disease Susceptibility; Fracture | 2013 |
[Pneumocystis carinii pneumonia complicating brain tumor].
Topics: Aged; Brain Neoplasms; Disease Susceptibility; Female; Humans; Immunocompromised Host; Male; Middle | 2004 |
CAPD-related peritonitis due to Salmonella enteritidis in a patient with SLE.
Topics: Catheterization; Device Removal; Disease Susceptibility; Female; Humans; Immunocompromised Host; Imm | 2005 |
Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiency.
Topics: Adolescent; Age Factors; Allopurinol; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Pr | 2006 |
Moyamoya syndrome following childhood acute lymphoblastic leukemia.
Topics: Adolescent; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cerebral I | 2007 |
A dilemma: bullous-pemphigoid-like eruption in scabies or scabies-induced bullous pemphigoid.
Topics: Animals; Anti-Inflammatory Agents; Complement C3; Diagnosis, Differential; Disease Susceptibility; H | 2006 |
Sialodacryoadenitis in the rat: effects of immunosuppression on the course of the disease.
Topics: Amylases; Animals; Coronaviridae Infections; Cyclophosphamide; Disease Susceptibility; Female; Immun | 1984 |
Listeriosis in sheep. Experimental listeric infection in sheep treated with various immunosuppressiva.
Topics: Animals; Cyclophosphamide; Disease Susceptibility; Immunosuppressive Agents; Listeriosis; Niridazole | 1980 |
Near fatal chickenpox during prednisolone treatment.
Topics: Adult; Chickenpox; Critical Care; Critical Illness; Disease Susceptibility; Female; Humans; Immunity | 1994 |
Fatal autoimmune pancytopenia following bone marrow transplantation for aplastic anaemia.
Topics: Adult; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Aspergillosis; Autoantibodies; Autoimmune Di | 1996 |
Susceptibility of various species of animals and strains of mice to Gymnophalloides seoi infection and the effects of immunosuppression in C3H/HeN mice.
Topics: Animals; Cats; Chickens; Cricetinae; Disease Susceptibility; Dogs; Ducks; Female; Gerbillinae; Gluco | 1997 |
Clinical significance of HLA-DRB1*0410 in Japanese patients with idiopathic thrombocytopenic purpura.
Topics: Adult; Aged; Alleles; Asian People; Autoantibodies; Autoimmune Diseases; Disease Susceptibility; Fem | 1998 |
Differential surface expression of HLA-DRB1 and HLA-DRB4 among peripheral blood cells of DR4 positive individuals.
Topics: Arthritis, Rheumatoid; Disease Susceptibility; Haplotypes; Histocompatibility Testing; HLA-DR Antige | 1999 |
Good's syndrome presenting with cytomegalovirus pneumonia.
Topics: Agammaglobulinemia; Antibody Formation; B-Lymphocytes; Cytomegalovirus Infections; Disease Susceptib | 2000 |
Systemic lupus erythematosus complicated by cytomegalovirus-induced hemophagocytic syndrome and colitis.
Topics: Autoimmune Diseases; Azathioprine; Colitis; Cyclophosphamide; Cytokines; Cytomegalovirus Infections; | 2002 |
[Experimental listeriosis in chickens: microbiological and anatomo-histopathological studies and health and hygiene considerations].
Topics: Abattoirs; Animals; Chickens; Disease Susceptibility; Eggs; Female; Food Contamination; Food Handlin | 1991 |
Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment. Spontaneous regression 8 months after discontinuing therapy.
Topics: Disease Susceptibility; HIV Seropositivity; HLA Antigens; Humans; Lung Diseases, Obstructive; Male; | 1991 |
Experimental infection of rhesus monkeys with Schistosoma incognitum and Orientobilharzia dattai.
Topics: Animals; Disease Susceptibility; Macaca mulatta; Male; Monkey Diseases; Prednisolone; Schistosoma; S | 1986 |