prednisolone has been researched along with Cryptogenic Infantile Spasms in 62 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Meta analysis showed that there was no significant difference in the spasm remission rate, spasm remission time, complicating infection rate, and irritability rate between the prednisolone and ACTH treatment groups (P>0." | 9.01 | [Effect of prednisolone and adrenocorticotropic hormone in the treatment of infantile spasms: a Meta analysis]. ( Luo, KR; Mu, DZ; Tang, J, 2019) |
| "To report a prospectively planned analysis of two randomised controlled trials with embedded comparisons of prednisolone versus tetracosactide depot for the treatment of infantile epileptic spasms syndrome (IESS)." | 8.31 | Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials. ( Alber, FD; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, M; Mallick, A; Newton, RW; Nolan, M; O'Callaghan, FK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2023) |
| "To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence." | 8.12 | Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022) |
| "BACKGROUND: High-dose prednisone and prednisolone have been increasingly studied as a lower-cost alternative to adrenocorticotropic hormone for the treatment of infantile spasms, but this treatment has not been well studied in children with infantile spasms due to perinatal stroke." | 8.02 | High-Dose Prednisolone for Treatment of Infantile Spasms After Presumed Perinatal Stroke. ( Golomb, MR; Hall, KR, 2021) |
| "Infantile spasms is a severe infantile seizure disorder that is difficult to treat and has a high morbidity." | 6.71 | The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. ( Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Lux, AL; Newton, RW; O'Callaghan, FJ; Osborne, JP; Verity, CM, 2005) |
| "Children with infantile spasms are often treated with hormonal therapies including adrenocorticotropic hormone (ACTH) and prednisolone." | 5.56 | Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. ( Cree-Green, M; Knupp, K; McGarry, L; Messer, R; Ray, K, 2020) |
| " Meta analysis showed that there was no significant difference in the spasm remission rate, spasm remission time, complicating infection rate, and irritability rate between the prednisolone and ACTH treatment groups (P>0." | 5.01 | [Effect of prednisolone and adrenocorticotropic hormone in the treatment of infantile spasms: a Meta analysis]. ( Luo, KR; Mu, DZ; Tang, J, 2019) |
| "To describe the temporal trends in the cost and use of adrenocorticotropic hormone (ACTH), oral prednisolone, and vigabatrin, the first-line treatments for infantile epileptic spasms syndrome (IESS)." | 4.31 | Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome. ( Amengual-Gual, M; Barcia Aguilar, C; Chao, J; Douglass, L; Gaínza-Lein, M; Harini, C; Jonas, R; Romeu, A; Sánchez Fernández, I; Sheikh, T; Torres, A, 2023) |
| "To report a prospectively planned analysis of two randomised controlled trials with embedded comparisons of prednisolone versus tetracosactide depot for the treatment of infantile epileptic spasms syndrome (IESS)." | 4.31 | Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials. ( Alber, FD; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, M; Mallick, A; Newton, RW; Nolan, M; O'Callaghan, FK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2023) |
| "Prednisolone is an effective and well-tolerated medication for treating infantile spasms in Down syndrome." | 4.12 | Response to treatment and outcomes of infantile spasms in Down syndrome. ( Allen, NM; Gorman, KM; Harvey, S; King, MD; Lynch, B; Lynch, SA; O'Regan, M; O'Rourke, D; Shahwan, A; Webb, D, 2022) |
| "To report response to first treatment in infants with infantile spasms (IS), including incremental benefit of prednisolone 60 mg/day and vigabatrin following prednisolone 40 mg/day failure in infants commenced on the United Kingdom Infantile Spasms Study (UKISS) treatment sequence." | 4.12 | Response to sequential treatment with prednisolone and vigabatrin in infantile spasms. ( Cheng, S; Dzau, W; Fahey, M; Harvey, AS; Howell, KB; Scheffer, IE; Snell, P, 2022) |
| "BACKGROUND: High-dose prednisone and prednisolone have been increasingly studied as a lower-cost alternative to adrenocorticotropic hormone for the treatment of infantile spasms, but this treatment has not been well studied in children with infantile spasms due to perinatal stroke." | 4.02 | High-Dose Prednisolone for Treatment of Infantile Spasms After Presumed Perinatal Stroke. ( Golomb, MR; Hall, KR, 2021) |
| " Stroke and infarct have a better outcome than other etiologies, whereas Down syndrome might not respond to the addition of vigabatrin to hormonal treatment." | 3.91 | The underlying etiology of infantile spasms (West syndrome): Information from the International Collaborative Infantile Spasms Study (ICISS). ( Dietrich Alber, F; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, M; Mallick, A; Newton, RW; Nolan, M; O'Callaghan, FJK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2019) |
| "A majority of children diagnosed with West syndrome continued to have seizures at age four years, although most were controlled on antiseizure medication." | 3.01 | Epilepsy Outcome at Four Years in a Randomized Clinical Trial Comparing Oral Prednisolone and Intramuscular ACTH in West Syndrome. ( Arambepola, C; Jayasundara, K; Ranganathan, SS; Wanigasinghe, J; Weerasinghe, A; Wickramarachchi, P, 2021) |
| "Rapid diagnosis and effective treatment of infantile spasms could therefore improve outcomes." | 2.87 | Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial. ( Alber, FD; Cortina Borja, M; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, MT; Mallick, AA; Newton, RW; Nolan, M; O'Callaghan, FJK; Osborne, JP; Pressler, R; Rating, D; Schmitt, B; Verity, CM, 2018) |
| "Infants with untreated West syndrome were randomized to receive 14 days of prednisolone (40 to 60 mg/day) or intramuscular long-acting ACTH (40 to 60 IU every other day)." | 2.84 | Randomized, Single-Blind, Parallel Clinical Trial on Efficacy of Oral Prednisolone Versus Intramuscular Corticotropin: A 12-Month Assessment of Spasm Control in West Syndrome. ( Arambepola, C; Ranganathan, SS; Sumanasena, S; Wanigasinghe, J, 2017) |
| "Newly diagnosed infants with West syndrome were randomized to receive 14 days of oral prednisolone (40-60 mg/day) or a synthetically prepared intramuscular long-acting adrenocorticotropic hormone (40-60 IU/every other day [0." | 2.80 | Randomized, Single-Blind, Parallel Clinical Trial on Efficacy of Oral Prednisolone Versus Intramuscular Corticotropin on Immediate and Continued Spasm Control in West Syndrome. ( Arambepola, C; Attanapola, G; Sri Ranganathan, S; Sumanasena, S; Wanigasinghe, J, 2015) |
| "Response (absence of both hypsarrhythmia and spasms) to prednisolone was ascertained by repeat overnight video-EEG." | 2.79 | Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. ( Hussain, SA; Kwong, G; Lerner, JT; Matsumoto, JH; Sankar, R; Shields, WD; Shinnar, S; Wu, JY, 2014) |
| "Improvement of hypsarrhythmia was assessed blindly using a hypsarrhythmia severity scale before and after completion of therapy." | 2.79 | The efficacy of moderate-to-high dose oral prednisolone versus low-to-moderate dose intramuscular corticotropin for improvement of hypsarrhythmia in West syndrome: a randomized, single-blind, parallel clinical trial. ( Arambepola, C; Muhandiram, EC; Sri Ranganathan, S; Sumanasena, S; Wanigasinghe, J, 2014) |
| "Infantile spasms is a severe infantile seizure disorder." | 2.76 | The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: evidence from the United Kingdom Infantile Spasms Study. ( Darke, K; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Lux, AL; Newton, RW; O'Callaghan, FJ; Osborne, JP; Verity, CM, 2011) |
| "Infantile spasms is the name given to a difficult to treat, severe infantile epilepsy with high morbidity." | 2.75 | Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial. ( Darke, K; Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Lux, AL; Newton, RW; O'Callaghan, FJ; Osborne, JP; Verity, CM, 2010) |
| "The ideal treatment of infantile spasms is unclear, but many studies advocate hormonal treatment." | 2.74 | High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH. ( Hartman, AL; Kossoff, EH; Rubenstein, JE; Vining, EP, 2009) |
| "Patients admitted with West syndrome in Children's Hospital, Islamabad, between January 1995 and December 2001 were included in the analysis." | 2.71 | Use of ACTH and prednisolone in infantile spasms: experience from a developing country. ( Azam, M; Bhatti, N; Krishin, J, 2005) |
| "Infantile spasms is a severe infantile seizure disorder that is difficult to treat and has a high morbidity." | 2.71 | The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. ( Edwards, SW; Hancock, E; Johnson, AL; Kennedy, CR; Lux, AL; Newton, RW; O'Callaghan, FJ; Osborne, JP; Verity, CM, 2005) |
| "Vigabatrin may be the treatment of choice in tuberous sclerosis." | 2.49 | Treatment of infantile spasms. ( Edwards, SW; Hancock, EC; Osborne, JP, 2013) |
| "Adrenal insufficiency is frequent and can potentially lead to an adrenal crisis in this population." | 1.72 | Adrenal insufficiency among children treated with hormonal therapy for infantile spasms. ( Chrestian, N; Doré-Brabant, G; Laflamme, G; Millette, M; Osterman, B, 2022) |
| "All consecutive children with hypsarrhythmia or hypsarrhythmia variant on EEG with/without IS, who had been treated with vigabatrin as first-line anti-seizure medication (ASM) followed by high-dose oral prednisolone (8 mg/kg/day; maximum 60 mg/day) in cases who did not respond to vigabatrin, were included." | 1.72 | Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms. ( Al-Shehhi, W; Boyd, J; Chau, V; Donner, E; Go, C; Jain, P; Sharma, R; Snead, C, 2022) |
| "It has been known that West syndrome (WS) patients with an unknown etiology have better clinical outcomes than patients with an identified etiology of any kind." | 1.62 | Disparate treatment outcomes according to presence of pathogenic mutations in West syndrome. ( Choi, HS; Choi, JR; Kang, HC; Kim, HD; Kim, SH; Ko, A; Lee, JS; Lee, ST, 2021) |
| "Children with infantile spasms are often treated with hormonal therapies including adrenocorticotropic hormone (ACTH) and prednisolone." | 1.56 | Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. ( Cree-Green, M; Knupp, K; McGarry, L; Messer, R; Ray, K, 2020) |
| "Relapse was relatively common among all subgroups." | 1.51 | Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol. ( Alayari, A; Eliyan, Y; Heesch, J; Hussain, SA; Rajaraman, RR; Sankar, R, 2019) |
| "The prednisolone dose was increased to 60 mg/day if spasms were still present or the BASED score was ≥3 on day 21." | 1.48 | Vigabatrin and high-dose prednisolone therapy for patients with West syndrome. ( Chung, HJ; Kang, HC; Kim, HD; Kim, SH; Ko, A; Lee, JS; Youn, SE, 2018) |
| "Treatment choice and categorization of hypsarrhythmia were determined clinically at each site." | 1.46 | The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. ( Bluvstein, JS; Chu, CJ; Demarest, ST; Gaillard, WD; Grinspan, Z; Hussain, SA; Joshi, S; Keator, C; Knupp, KG; Loddenkemper, T; Mohamed, IS; Nickels, KC; Patel, AD; Sánchez Fernández, I; Saneto, RP; Shellhaas, RA; Singh, RK; Stack, CV; Stafstrom, CE; Wirrell, E; Wusthoff, CJ; Yozawitz, E, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (9.68) | 18.7374 |
| 1990's | 1 (1.61) | 18.2507 |
| 2000's | 3 (4.84) | 29.6817 |
| 2010's | 30 (48.39) | 24.3611 |
| 2020's | 22 (35.48) | 2.80 |
| Authors | Studies |
|---|---|
| Harvey, S | 1 |
| Allen, NM | 1 |
| King, MD | 1 |
| Lynch, B | 1 |
| Lynch, SA | 1 |
| O'Regan, M | 1 |
| O'Rourke, D | 1 |
| Shahwan, A | 1 |
| Webb, D | 1 |
| Gorman, KM | 1 |
| Doré-Brabant, G | 1 |
| Laflamme, G | 1 |
| Millette, M | 1 |
| Osterman, B | 1 |
| Chrestian, N | 1 |
| Mytinger, JR | 6 |
| Parker, W | 1 |
| Rust, SW | 1 |
| Ahrens, SM | 1 |
| Albert, DVF | 2 |
| Beatty, CW | 1 |
| Chrisman, J | 1 |
| Clark, DJ | 1 |
| Debs, A | 1 |
| Denney, D | 1 |
| Karn, M | 1 |
| Herbst, J | 1 |
| Ostendorf, AP | 2 |
| Taylor, MC | 1 |
| Twanow, JDE | 1 |
| Vidaurre, J | 2 |
| Patel, AD | 3 |
| Dzau, W | 1 |
| Cheng, S | 1 |
| Snell, P | 1 |
| Fahey, M | 1 |
| Scheffer, IE | 1 |
| Harvey, AS | 1 |
| Howell, KB | 1 |
| Sakpichaisakul, K | 2 |
| Boonkrongsak, R | 2 |
| Lertbutsayanukul, P | 2 |
| Iemwimangsa, N | 2 |
| Klumsathian, S | 2 |
| Panthan, B | 2 |
| Trachoo, O | 2 |
| Sánchez Fernández, I | 3 |
| Amengual-Gual, M | 2 |
| Barcia Aguilar, C | 2 |
| Romeu, A | 1 |
| Sheikh, T | 1 |
| Torres, A | 1 |
| Chao, J | 1 |
| Jonas, R | 1 |
| Gaínza-Lein, M | 2 |
| Harini, C | 3 |
| Douglass, L | 1 |
| Osborne, JP | 8 |
| Edwards, SW | 8 |
| Alber, FD | 3 |
| Hancock, E | 8 |
| Johnson, AL | 7 |
| Kennedy, CR | 7 |
| Likeman, M | 4 |
| Lux, AL | 7 |
| Mackay, M | 3 |
| Mallick, A | 2 |
| Newton, RW | 7 |
| Nolan, M | 4 |
| Pressler, R | 4 |
| Rating, D | 4 |
| Schmitt, B | 4 |
| Verity, CM | 7 |
| O'Callaghan, FK | 1 |
| Sampaio, LPB | 1 |
| Henriques-Souza, AMM | 1 |
| Silveira, MRMD | 1 |
| Seguti, L | 1 |
| Santos, MLSF | 1 |
| Montenegro, MA | 1 |
| Antoniuk, S | 1 |
| Manreza, MLG | 1 |
| Dietrich Alber, F | 1 |
| O'Callaghan, FJK | 2 |
| Chang, YH | 1 |
| Chen, C | 1 |
| Chen, SH | 1 |
| Shen, YC | 1 |
| Kuo, YT | 1 |
| McGarry, L | 1 |
| Messer, R | 1 |
| Cree-Green, M | 1 |
| Ray, K | 1 |
| Knupp, K | 1 |
| Gupta, A | 1 |
| Li, S | 1 |
| Zhong, X | 1 |
| Hong, S | 1 |
| Li, T | 1 |
| Jiang, L | 1 |
| Twanow, JD | 1 |
| Tan, Y | 1 |
| Brock, GN | 1 |
| Kelley, SA | 2 |
| Grinspan, ZM | 1 |
| Baumer, FM | 1 |
| Ciliberto, MA | 1 |
| Cohen, BH | 1 |
| Dlugos, DJ | 2 |
| Hussain, SA | 4 |
| Joshi, SM | 1 |
| Keator, CG | 1 |
| Knupp, KG | 3 |
| McGoldrick, PE | 1 |
| Nickels, KC | 2 |
| Park, JT | 1 |
| Pasupuleti, A | 1 |
| Pomeroy, SL | 1 |
| Shahid, AM | 1 |
| Shellhaas, RA | 2 |
| Shrey, DW | 1 |
| Singh, RK | 2 |
| Wolf, SM | 1 |
| Yozawitz, EG | 1 |
| Yuskaitis, CJ | 2 |
| Waugh, JL | 1 |
| Pearl, PL | 1 |
| Bergin, AM | 1 |
| Bashiri, FA | 1 |
| Al-Sehemi, MA | 1 |
| Hamad, MH | 1 |
| Alshammari, NR | 1 |
| Aljumah, MA | 1 |
| Kentab, A | 1 |
| Salih, MA | 1 |
| Hall, KR | 1 |
| Golomb, MR | 1 |
| Kapoor, D | 1 |
| Sharma, S | 2 |
| Garg, D | 1 |
| Samaddar, S | 1 |
| Panda, I | 1 |
| Patra, B | 1 |
| Mukherjee, SB | 1 |
| Pemde, HK | 1 |
| Wanigasinghe, J | 5 |
| Arambepola, C | 6 |
| Ranganathan, SS | 2 |
| Jayasundara, K | 1 |
| Weerasinghe, A | 1 |
| Wickramarachchi, P | 1 |
| Sumanasena, SP | 1 |
| Sri Ranganathan, S | 3 |
| Muhandiram, E | 1 |
| Choi, HS | 1 |
| Ko, A | 2 |
| Kim, SH | 2 |
| Lee, ST | 1 |
| Choi, JR | 1 |
| Lee, JS | 2 |
| Kim, HD | 2 |
| Kang, HC | 2 |
| Al-Shehhi, W | 1 |
| Chau, V | 1 |
| Boyd, J | 2 |
| Snead, C | 1 |
| Sharma, R | 1 |
| Donner, E | 1 |
| Go, C | 2 |
| Jain, P | 2 |
| Fosi, T | 1 |
| Werner, K | 1 |
| Boyd, SG | 1 |
| De Haan, M | 1 |
| Scott, RC | 1 |
| Neville, BG | 1 |
| Wanigsinghe, J | 1 |
| Sumanasena, S | 3 |
| Demarest, ST | 1 |
| Gaillard, WD | 2 |
| Keator, C | 1 |
| Loddenkemper, T | 1 |
| Saneto, RP | 1 |
| Wirrell, E | 1 |
| Chu, CJ | 1 |
| Grinspan, Z | 1 |
| Wusthoff, CJ | 1 |
| Joshi, S | 1 |
| Mohamed, IS | 1 |
| Stafstrom, CE | 2 |
| Stack, CV | 1 |
| Yozawitz, E | 1 |
| Bluvstein, JS | 1 |
| Youn, SE | 1 |
| Chung, HJ | 1 |
| Gowda, VK | 1 |
| Narayanaswamy, V | 1 |
| Shivappa, SK | 1 |
| Benakappa, N | 1 |
| Benakappa, A | 1 |
| Cortina Borja, M | 1 |
| Mackay, MT | 1 |
| Mallick, AA | 2 |
| Gill, RE | 1 |
| Morrow, C | 1 |
| Kossoff, E | 1 |
| Gonzalez-Giraldo, E | 1 |
| Stanfield, AC | 1 |
| Kossoff, EH | 2 |
| Kesavan, S | 1 |
| Sankhyan, N | 1 |
| Armstrong, D | 1 |
| Said, RR | 1 |
| Luo, KR | 1 |
| Tang, J | 1 |
| Mu, DZ | 1 |
| Eliyan, Y | 1 |
| Heesch, J | 1 |
| Alayari, A | 1 |
| Rajaraman, RR | 1 |
| Sankar, R | 2 |
| Hancock, EC | 1 |
| Shinnar, S | 2 |
| Kwong, G | 1 |
| Lerner, JT | 1 |
| Matsumoto, JH | 1 |
| Wu, JY | 1 |
| Shields, WD | 2 |
| Heyer, GL | 1 |
| Muhandiram, EC | 1 |
| Jones, K | 1 |
| Snead, OC | 1 |
| Chellamuthu, P | 1 |
| Kaushik, JS | 1 |
| Seth, A | 1 |
| Aneja, S | 1 |
| Attanapola, G | 1 |
| Camfield, PR | 1 |
| Tiwari, L | 1 |
| Kumar, M | 1 |
| O'Callaghan, FJ | 4 |
| Hartman, AL | 1 |
| Rubenstein, JE | 1 |
| Vining, EP | 1 |
| Darke, K | 2 |
| Pellock, JM | 1 |
| Hrachovy, R | 1 |
| Baram, TZ | 1 |
| Bettis, D | 1 |
| Gibson, PA | 1 |
| Holmes, GL | 1 |
| Nordl, DR | 1 |
| O'Dell, C | 1 |
| Trevathan, E | 1 |
| Wheless, JW | 1 |
| FUELOEP, T | 1 |
| KAISER, E | 1 |
| FARKAS, G | 1 |
| Azam, M | 1 |
| Bhatti, N | 1 |
| Krishin, J | 1 |
| Osborne, J | 1 |
| Low, PS | 1 |
| Pavone, L | 1 |
| Mollica, F | 1 |
| Incorpora, G | 1 |
| Pampiglione, G | 1 |
| Iwakawa, Y | 1 |
| Ogiso, M | 1 |
| Suzuki, H | 1 |
| Kawano, Y | 1 |
| Koyama, J | 1 |
| Shimohira, M | 1 |
| Danielsen, J | 1 |
| Nielsen, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Methylprednisolone Versus High Dose Oral Prednisolone for the Treatment of Infantile Spasms: a Randomized Open-labelled Trial[NCT03876444] | Phase 2/Phase 3 | 128 participants (Anticipated) | Interventional | 2019-04-01 | Recruiting | ||
| Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
| Effect of Neuro Developmental Therapy to Improve Postural Reactions and Motor Milestones in Infants With Down Syndrome[NCT04816409] | 20 participants (Actual) | Interventional | 2019-03-15 | Completed | |||
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| Randomized Trial of High Dose (4mg/kg) Versus Usual Dose (2mg/kg) Oral Prednisolone in the Treatment of Infantile Spasms.[NCT01575639] | Phase 3 | 63 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Decreasing Parental Stress and Costs While Improving Overall Satisfaction of Caregivers of Infants With Infantile Spasms on ACTH Therapy Utilizing Innovative Telemedicine Technology: A Randomized Study[NCT04086992] | 40 participants (Anticipated) | Interventional | 2019-10-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for prednisolone and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Effectiveness of corticosteroids versus adrenocorticotropic hormone for infantile spasms: a systematic review and meta-analysis.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Humans; Infant; Pred | 2019 |
Prednisolone/prednisone as adrenocorticotropic hormone alternative for infantile spasms: a meta-analysis of randomized controlled trials.
Topics: Adrenocorticotropic Hormone; Humans; Infant; Parasympatholytics; Prednisolone; Prednisone; Randomize | 2020 |
Cost-effectiveness of adrenocorticotropic hormone versus oral steroids for infantile spasms.
Topics: Adrenocorticotropic Hormone; Cost-Benefit Analysis; Decision Support Techniques; Dose-Response Relat | 2021 |
Infantile Spasms-Have We Made Progress?
Topics: Adrenocorticotropic Hormone; Animals; Anticonvulsants; Child; Child, Preschool; Combined Modality Th | 2018 |
West Syndrome: Questions Aplenty- Few Answers.
Topics: Adrenocorticotropic Hormone; Humans; Prednisolone; Spasms, Infantile | 2019 |
[Effect of prednisolone and adrenocorticotropic hormone in the treatment of infantile spasms: a Meta analysis].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; China; Humans; Infant; Prednisolone; Spasm; Spasms, In | 2019 |
Treatment of infantile spasms.
Topics: Anticonvulsants; Cosyntropin; Hormones; Humans; Infant; Prednisolone; Psychomotor Performance; Rando | 2013 |
Infantile spasms: a U.S. consensus report.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Consensus; Consensus Developm | 2010 |
Infantile spasms: a U.S. consensus report.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Consensus; Consensus Developm | 2010 |
Infantile spasms: a U.S. consensus report.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Consensus; Consensus Developm | 2010 |
Infantile spasms: a U.S. consensus report.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Consensus; Consensus Developm | 2010 |
16 trials available for prednisolone and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Intravenous Methylprednisolone Versus Oral Prednisolone for West Syndrome: A Randomized Open-Label Trial.
Topics: Administration, Intravenous; Child, Preschool; Humans; Infant; Methylprednisolone; Prednisolone; Res | 2021 |
Epilepsy Outcome at Four Years in a Randomized Clinical Trial Comparing Oral Prednisolone and Intramuscular ACTH in West Syndrome.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Child, Preschool; Female; Follow-Up Studies; Gluc | 2021 |
Effect of intramuscular ACTH versus oral prednisolone on the developmental trajectories of children with West syndrome over 24 months: A randomised control study.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Child, Preschool; Hormones; Humans; Infant; Injec | 2021 |
Randomized, Single-Blind, Parallel Clinical Trial on Efficacy of Oral Prednisolone Versus Intramuscular Corticotropin: A 12-Month Assessment of Spasm Control in West Syndrome.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Female; Follow-Up Studies; Glucocorticoids; Human | 2017 |
Corticotrophin-ACTH in Comparison to Prednisolone in West Syndrome - A Randomized Study.
Topics: Adrenocorticotropic Hormone; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Epil | 2019 |
Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial.
Topics: Cosyntropin; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Female | 2018 |
Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone.
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Child; Child, Preschool; Drug Administrati | 2014 |
The efficacy of moderate-to-high dose oral prednisolone versus low-to-moderate dose intramuscular corticotropin for improvement of hypsarrhythmia in West syndrome: a randomized, single-blind, parallel clinical trial.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Child, Preschool; Dose- | 2014 |
High dose (4 mg/kg/day) versus usual dose (2 mg/kg/day) oral prednisolone for treatment of infantile spasms: an open-label, randomized controlled trial.
Topics: Administration, Oral; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Studies; | 2014 |
Randomized, Single-Blind, Parallel Clinical Trial on Efficacy of Oral Prednisolone Versus Intramuscular Corticotropin on Immediate and Continued Spasm Control in West Syndrome.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Anticonvulsants; Female; Humans; Infant; Injectio | 2015 |
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial.
Topics: Anticonvulsants; Cosyntropin; Drug Administration Schedule; Drug Therapy, Combination; Electroenceph | 2017 |
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial.
Topics: Anticonvulsants; Cosyntropin; Drug Administration Schedule; Drug Therapy, Combination; Electroenceph | 2017 |
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial.
Topics: Anticonvulsants; Cosyntropin; Drug Administration Schedule; Drug Therapy, Combination; Electroenceph | 2017 |
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial.
Topics: Anticonvulsants; Cosyntropin; Drug Administration Schedule; Drug Therapy, Combination; Electroenceph | 2017 |
High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Female; Glucocorticoids; Humans; Infant; Male; Pr | 2009 |
High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Female; Glucocorticoids; Humans; Infant; Male; Pr | 2009 |
High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Female; Glucocorticoids; Humans; Infant; Male; Pr | 2009 |
High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Female; Glucocorticoids; Humans; Infant; Male; Pr | 2009 |
Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial.
Topics: Anticonvulsants; Child Development; Child, Preschool; Cosyntropin; Epidemiologic Methods; Glucocorti | 2010 |
The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: evidence from the United Kingdom Infantile Spasms Study.
Topics: Age of Onset; Anticonvulsants; Child Development; Cosyntropin; Early Diagnosis; Humans; Infant; Infa | 2011 |
Use of ACTH and prednisolone in infantile spasms: experience from a developing country.
Topics: Adrenocorticotropic Hormone; Child, Preschool; Developing Countries; Electroencephalography; Female; | 2005 |
The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial.
Topics: Adaptation, Psychological; Anti-Inflammatory Agents; Anticonvulsants; Child Development; Cosyntropin | 2005 |
38 other studies available for prednisolone and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Response to treatment and outcomes of infantile spasms in Down syndrome.
Topics: Adult; Anticonvulsants; Child; Down Syndrome; Humans; Infant; Prednisolone; Seizures; Spasm; Spasms, | 2022 |
Adrenal insufficiency among children treated with hormonal therapy for infantile spasms.
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Child; Humans; Hydrocor | 2022 |
Prioritizing Hormone Therapy Over Vigabatrin as the First Treatment for Infantile Spasms: A Quality Improvement Initiative.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child, Preschool; Cohort Studies; Humans; Infant; Pred | 2022 |
Response to sequential treatment with prednisolone and vigabatrin in infantile spasms.
Topics: Anticonvulsants; Humans; Infant; Prednisolone; Recurrence; Retrospective Studies; Spasm; Spasms, Inf | 2022 |
Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high dose prednisolone therapy.
Topics: Anticonvulsants; Basic Helix-Loop-Helix Transcription Factors; Female; Humans; Infant; Mutation; Neu | 2022 |
Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high dose prednisolone therapy.
Topics: Anticonvulsants; Basic Helix-Loop-Helix Transcription Factors; Female; Humans; Infant; Mutation; Neu | 2022 |
Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high dose prednisolone therapy.
Topics: Anticonvulsants; Basic Helix-Loop-Helix Transcription Factors; Female; Humans; Infant; Mutation; Neu | 2022 |
Epileptic spasms related to neuronal differentiation factor 2 (NEUROD2) mutation respond to combined vigabatrin and high dose prednisolone therapy.
Topics: Anticonvulsants; Basic Helix-Loop-Helix Transcription Factors; Female; Humans; Infant; Mutation; Neu | 2022 |
Temporal trends in the cost and use of first-line treatments for infantile epileptic spasms syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Female; Humans; Infant; Infant, Newborn; Male; | 2023 |
Prednisolone or tetracosactide depot for infantile epileptic spasms syndrome? A prospective analysis of data embedded within two randomised controlled trials.
Topics: Anticonvulsants; Cosyntropin; Epilepsy; Humans; Infant; Prednisolone; Randomized Controlled Trials a | 2023 |
Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants.
Topics: Anticonvulsants; Brazil; Child; Consensus; Epilepsy; Humans; Infant; Prednisolone; Recurrence; Spasm | 2023 |
The underlying etiology of infantile spasms (West syndrome): Information from the International Collaborative Infantile Spasms Study (ICISS).
Topics: Anticonvulsants; Female; Humans; Infant; Male; Malformations of Cortical Development; Prednisolone; | 2019 |
Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms.
Topics: Adrenocorticotropic Hormone; Causality; Child, Preschool; Colorado; Comorbidity; Female; Glucocortic | 2020 |
Corticotrophin-ACTH in Comparison to Prednisolone in West Syndrome - A Randomized Study: Correspondence.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Humans; Prednisolone; Spasms, Infantile | 2020 |
Compliance With Standard Therapies and Remission Rates After Implementation of an Infantile Spasms Management Guideline.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Female; Glucocorticoids; Guideline Adherence; Humans; | 2020 |
Corticosteroids and ACTH for infantile spasms: are we closer to equipoise?
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Humans; Prednisolone; Prednisone; Randomized C | 2020 |
Crisis Standard of Care: Management of Infantile Spasms during COVID-19.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Betacoronavirus; Coronavirus Infections; COVID-19; Del | 2020 |
Neurodevelopmental and epilepsy outcomes of patients with infantile spasms treated in a tertiary care center.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Infant; Inf | 2021 |
High-Dose Prednisolone for Treatment of Infantile Spasms After Presumed Perinatal Stroke.
Topics: Child; Female; Humans; Infant; Prednisolone; Spasm; Spasms, Infantile; Stroke; Treatment Outcome | 2021 |
Disparate treatment outcomes according to presence of pathogenic mutations in West syndrome.
Topics: Age of Onset; Anti-Inflammatory Agents; Anticonvulsants; Arrhythmias, Cardiac; Child; Child, Prescho | 2021 |
Treatment with High-Dose Prednisolone in Vigabatrin-Refractory Infantile Spasms.
Topics: Anticonvulsants; Child; Humans; Infant; Prednisolone; Spasms, Infantile; Treatment Outcome; Vigabatr | 2022 |
Auditory processing following infantile spasms: An event-related potential study.
Topics: Acoustic Stimulation; Auditory Pathways; Auditory Perception; Case-Control Studies; Cerebral Cortex; | 2017 |
Letter Reply.
Topics: Adrenocorticotropic Hormone; Humans; Prednisolone; Single-Blind Method; Spasms, Infantile | 2017 |
The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium.
Topics: Adrenocorticotropic Hormone; Age of Onset; Anticonvulsants; Cohort Studies; Female; Humans; Infant; | 2017 |
Vigabatrin and high-dose prednisolone therapy for patients with West syndrome.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug | 2018 |
A Serendipitous Case for Shorter Steroid Course in Infantile Spasms.
Topics: Acyclovir; Drug Administration Schedule; Glucocorticoids; Humans; Infant; Male; Prednisolone; Spasms | 2019 |
High-Dose Prednisolone as a First-line Treatment for Infantile Spasms.
Topics: Adrenal Cortex Hormones; Child; Humans; Prednisolone; Retrospective Studies; Spasms, Infantile; Viga | 2018 |
Treating Infantile Spasms with High-Dose Oral Corticosteroids: A Retrospective Review of 87 Children.
Topics: Adrenal Cortex Hormones; Female; Humans; Infant; Infant, Newborn; Male; Outcome Assessment, Health C | 2018 |
Outcomes of High-Dose Steroid Therapy for Infantile Spasms in Children With Trisomy 21.
Topics: Adolescent; Adrenal Cortex Hormones; Anticonvulsants; Brain; Child; Child, Preschool; Down Syndrome; | 2019 |
Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Clinical Protocols; Cohort Studies; Disease Susceptibi | 2019 |
Oral corticosteroids versus adrenocorticotropic hormone for infantile spasms--an unfinished story.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Female; Humans; Male; Prednisolone; Spasms, I | 2014 |
Adrenocorticotropic hormone versus prednisolone in the treatment of infantile spasms post vigabatrin failure.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Cohort Studies; Female; Humans; Infant; Male; Predniso | 2015 |
Synthetic ACTH Is Not Superior to Prednisolone for Infantile Spasms: Randomized Clinical Trials and Tribulations.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Female; Humans; Male; Prednisolone; Spasms, Infantile | 2015 |
Oral Prednisolone Versus Intramuscular Corticotropin in West Syndrome.
Topics: Adrenocorticotropic Hormone; Humans; Injections, Intramuscular; Prednisolone; Single-Blind Method; S | 2016 |
[TREATMENT OF HYPSARRHYTHMIA ASSOCIATED WITH FLEXOR SPASM WITH ACTH AND PREDNISOLONE].
Topics: Adolescent; Adrenocorticotropic Hormone; Asphyxia Neonatorum; Child; Down Syndrome; Electroencephalo | 1964 |
Treatment of infantile spasms with high-dose oral prednisolone.
Topics: Administration, Oral; Glucocorticoids; Humans; Infant; Infant, Newborn; Prednisolone; Prognosis; Spa | 1998 |
Infantile spasms--a clinical perspective.
Topics: Adrenocorticotropic Hormone; Electroencephalography; Epilepsy; Humans; Infant; Prednisolone; Prognos | 1989 |
Infantile spasms syndrome in monozygotic twins. A 7-year follow-up.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diseases in Twins; Drug Therapy, C | 1985 |
Polygraphical study on age dependent epileptic encephalopathy--relationship between body movements during sleep and prognosis.
Topics: Adolescent; Adrenocorticotropic Hormone; Age Factors; Child; Child, Preschool; Epilepsy; Female; Hum | 1986 |
Infantile spasms and hypsarhythmia treated with corticosteroids.
Topics: Adrenocorticotropic Hormone; Brain Diseases; Cerebral Ventriculography; Electroencephalography; Huma | 1965 |
[Hypsarrhythmia and triple vaccination].
Topics: Child, Preschool; Electroencephalography; Female; Humans; Male; Prednisolone; Spasms, Infantile; Vac | 1968 |