Page last updated: 2024-11-06

prednisolone and Corneal Ulcer

prednisolone has been researched along with Corneal Ulcer in 71 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Corneal Ulcer: Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.

Research Excerpts

ExcerptRelevanceReference
"The Steroids for Corneal Ulcers Trial (SCUT) was a randomized, double-masked, placebo-controlled trial assessing outcomes in patients with culture positive bacterial corneal ulcers randomized to receive prednisolone phosphate or placebo."5.17Emerging moxifloxacin resistance in Pseudomonas aeruginosa keratitis isolates in South India. ( Acharya, NR; Borkar, DS; Lalitha, P; Lietman, TM; Mascarenhas, J; McLeod, SD; Oldenburg, CE; Porco, TC; Rajaraman, R; Ravindran, M; Ray, KJ; Srinivasan, M; Zegans, ME, 2013)
"In the Steroids for Corneal Ulcers Trial (SCUT), 500 corneal infections were treated with topical moxifloxacin."5.17Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis. ( Acharya, NR; Bharathi, MJ; Glidden, DV; Lalitha, P; Lietman, TM; Manikandan, P; Mascarenhas, J; Nardone, N; Oldenburg, CE; Rajaraman, R; Ravindran, M; Ray, KJ; Srinivasan, M, 2013)
"Baseline data from a 1:1 randomized, placebo-controlled, double-masked clinical trial comparing prednisolone phosphate, 1%, with placebo as adjunctive therapy for the treatment of bacterial corneal ulcers."5.16The steroids for corneal ulcers trial: study design and baseline characteristics. ( Acharya, NR; Glidden, DV; Hong, KC; Lalitha, P; Lee, SM; Lietman, TM; Mascarenhas, J; McLeod, SD; Oldenburg, CE; Rajaraman, R; Ravindran, M; Ray, KJ; Srinivasan, M; Zegans, ME, 2012)
"Subanalyses were performed on data collected in the Steroids for Corneal Ulcers Trial (SCUT), a large randomized controlled trial in which patients were treated with moxifloxacin and were randomly assigned to 1 of 2 adjunctive treatment arms: corticosteroid or placebo (4 times a day with subsequent reduction)."5.16Pseudomonas aeruginosa keratitis: outcomes and response to corticosteroid treatment. ( Acharya, NR; Glidden, D; Lalitha, P; Lietman, TM; Mascarenhas, J; McLeod, SD; Oldenburg, CE; Rajaraman, R; Ravindran, M; Ray, KJ; Srinivasan, M; Sy, A; Zegans, ME, 2012)
"A 60-year-old female with a 39°C fever and bilateral parotid swelling diagnosed with mumps and treated for photophobia, pain, redness, and decreased vision in 1 eye, was referred to our hospital when her condition deteriorated despite receiving betamethasone phosphate instillation and antiglaucoma agents for elevated intraocular pressure (52 mm Hg) and iritis."3.83An Adult Case of Fulminant Mumps Keratitis With Positive Viral RNA in Aqueous Humor Detected by RT-PCR. ( Kitagawa, K; Okamoto, A; Sasaki, H; Shibata, T; Takahashi, Y, 2016)
" Postoperative uveitis was controlled with oral prednisolone."3.72Bilateral phacofragmentation in a New Zealand fur seal (Arctocephalus forsteri). ( Barnes, JA; Smith, JS, 2004)
"To assess the effect of intensive topical and intravenous antibiotics plus oral prednisolone and surgical debridement in Pseudomonas keratoscleritis after pterygium excision."3.70The treatment of Pseudomonas keratoscleritis after pterygium excision. ( Huang, SC; Lai, HC; Lai, IC, 1999)
"Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition."2.73Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine. ( Araujo, DM; Esmaeli, B; Espandar, L; Hatef, E; Kim, SK; Shome, D; Song, CD; Trent, J, 2008)
"Reactive arthritis is occasionally associated with conjunctivitis and uveitis, but rarely keratitis."1.43Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( AlQahtani, E; Gardiner, J; Lyons, CJ; Moloney, GT; Tsang, H, 2016)
"Sodium hypochlorite is an effective antibacterial irrigant indicated for the treatment of root canal infections."1.40Sodium hypochlorite chemical burn in an endodontist's eye during canal treatment using operating microscope. ( Estrela, C; Puente, CG; Regalado Farreras, DC, 2014)
"Bacterial keratitis results in corneal scarring and subsequent visual impairment."1.39Improvement in corneal scarring following bacterial keratitis. ( Acharya, NR; Greninger, DA; Keenan, JD; Lietman, TM; Mascarenhas, J; McClintic, SM; Srinivasan, M, 2013)
"An elderly white woman with stable ocular cicatricial pemphigoid underwent an uncomplicated clear corneal phacoemulsification procedure in the left eye."1.37Peripheral ulcerative keratitis after cataract surgery in a patient with ocular cicatricial pemphigoid. ( Inglis, A; Kiire, CA; Srinivasan, S, 2011)
"Peripheral ulcerative keratitis is a destructive process involving perilimbal corneal inflammation and an overlying epithelial defect."1.37Peripheral ulcerative keratitis in a child. ( Ali, A; Leung, AK; Mireskandari, K, 2011)
"One month later, a recurrence of PUK on the donor button was noted."1.35Recurrence of peripheral ulcerative keratitis on the corneoscleral button in a young man treated successfully with oral corticosteroids. ( Bakiah, S; Ibrahim, M; Selvaraja, V; Wahid, WA, 2008)
"The diagnosis was bilateral vernal keratoconjunctivitis with shield ulcer in the right eye."1.35Combined therapy for vernal shield ulcer. ( Kumar, S, 2008)
"Wegener's granulomatosis is a rare necrotising vasculitis not easily diagnosed due to the obscurity of its diverse clinical features."1.34Unusual eye signs in Wegener's granulomatosis. ( Chan, AY; Choi, PC; Lam, DS; Lam, PT; Li, EK; Liu, DT, 2007)
"To report a patient with vernal keratoconjunctivitis-induced shield ulcer superinfected with Staphylococcus aureus."1.33Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis. ( Akova, YA; Gedik, S; Gür, S, 2006)
" These results suggest that either salt of prednisolone, when combined with ciprofloxacin, reduces ocular inflammation without affecting the antimicrobial efficacy of the antibiotic."1.29Prednisolone acetate or prednisolone phosphate concurrently administered with ciprofloxacin for the therapy of experimental Pseudomonas aeruginosa keratitis. ( Callegan, MC; Engel, LS; Hill, JM; Hobden, JA; O'Callaghan, RJ, 1993)
"Three AIDS patients with ocular herpes zoster infection (mean age at onset, 33."1.29Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome. ( Belfort, R; Foster, CS; Lane, L; Muccioli, C; Neves, RA; Power, WJ; Rodriguez, A, 1996)

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-199021 (29.58)18.7374
1990's8 (11.27)18.2507
2000's13 (18.31)29.6817
2010's29 (40.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Urkude, J1
Singh, R1
Chaniyara, M1
Pujari, A1
Wu, YT1
Truong, TN2
Tam, C1
Mendoza, MN2
Zhu, L1
Evans, DJ1
Fleiszig, SMJ1
Ashar, JN1
Mathur, A1
Sangwan, VS1
Oldenburg, CE10
Lalitha, P10
Srinivasan, M14
Rajaraman, R9
Ravindran, M8
Mascarenhas, J11
Borkar, DS1
Ray, KJ11
Zegans, ME8
McLeod, SD8
Porco, TC2
Lietman, TM14
Acharya, NR14
Papakostas, TD1
Kohanim, S1
Skondra, D1
Lo, K1
Chodosh, J1
O'Brien, KS2
Glidden, DV5
Whitcher, JP4
Keenan, JD3
McClintic, SM2
Prajna, NV2
Schneider, LR1
Shorter, E1
Cortina, MS1
Krall, P1
Kubal, A1
Regalado Farreras, DC1
Puente, CG1
Estrela, C1
Shibata, T1
Takahashi, Y1
Okamoto, A1
Sasaki, H1
Kitagawa, K1
Höllhumer, R1
Zairani Mz, A1
Watson, S1
Lyons, CJ1
AlQahtani, E1
Tsang, H1
Moloney, GT1
Gardiner, J1
Wahid, WA1
Selvaraja, V1
Bakiah, S1
Ibrahim, M1
Mahalakshmi, R2
Chidambaram, JD1
Lee, S1
Hong, KC3
Zegans, M1
McLeod, S2
Berger, EA1
McClellan, SA1
Barrett, RP1
Hazlett, LD1
Das, S1
Sharma, S1
Sahu, SK1
Vemuganti, GK1
Kiire, CA1
Srinivasan, S1
Inglis, A1
Meskin, SW1
Carlson, EM1
Lee, SM2
Leung, AK1
Mireskandari, K1
Ali, A1
Sy, A2
Glidden, D2
Praidou, A1
Androudi, S1
Kanonidou, E1
Konidaris, V1
Alexandridis, A1
Brazitikos, P1
Priya, JL1
Labiris, G1
Troeber, L1
Gatzioufas, Z1
Stavridis, E1
Seitz, B1
See, CW1
Saravanan, S1
Esterberg, EJ1
Glaser, TS1
Tu, EY1
Greninger, DA1
Prajna, L2
Geetha, M1
Karpagam, R1
Sun, CQ1
Manikandan, P1
Bharathi, MJ1
Nardone, N1
CROMPTON, DO1
ARNOTT, EJ1
GREAVES, DP1
Lee, EJ1
Fleiszig, SM1
Barnes, JA1
Smith, JS1
Jin, GJ1
Lyle, WA1
Merkley, KH1
Lanier, JD1
Dawson, CR1
Oh, JO1
Tan, MH1
Chen, SD1
Rubinstein, A1
Bron, AJ1
Gedik, S1
Akova, YA1
Gür, S1
Chan, AY1
Li, EK1
Choi, PC1
Liu, DT1
Lam, PT1
Lam, DS1
Chawla, B1
Agarwal, P1
Tandon, R1
Titiyal, JS1
Kumar, S1
Shome, D1
Trent, J1
Espandar, L1
Hatef, E1
Araujo, DM1
Song, CD1
Kim, SK1
Esmaeli, B1
Chen, A1
Knecht, CD1
Schiller, AG1
Small, E1
Phillips, K1
Arffa, R1
Cintron, C1
Rose, J1
Miller, D2
Kublin, CL1
Kenyon, KR2
Petroutsos, G1
Guimaraes, R1
Giraud, JP1
Pouliquen, Y1
Poirier, RH1
Hobden, JA1
Engel, LS1
Hill, JM1
Callegan, MC1
O'Callaghan, RJ1
Neves, RA1
Rodriguez, A1
Power, WJ1
Muccioli, C1
Lane, L1
Belfort, R1
Foster, CS2
Scott, IU1
Flynn, HW1
Feuer, W1
Pflugfelder, SC1
Alfonso, EC1
Forster, RK2
Dada, T1
Kumar, A1
Sharma, N1
Yang, J1
Baltatzis, S1
Huang, SC1
Lai, HC1
Lai, IC1
Smith, VA1
Hoh, HB1
Easty, DL3
Sirois, D1
Leigh, JE1
Sollecito, TP1
el-Gammal, MY1
el-Din Mostafa, MS1
Rebell, G1
Stiles, W1
Smolin, G1
Okumoto, M1
Jones, BR1
McGill, JI2
Steele, AD1
Lesher, MP1
Lohman, LE1
Yeakley, W1
Lass, J1
Aonuma, Y1
Itoh, M1
Hakamata, M1
Endo, S1
Ohashi, H1
Okugawa, T1
Yamazaki, N1
Climenhaga, DB1
Jackson, WB1
Delcarpio, J1
Struck, HG1
Franke, C1
Tost, M1
Taube, C1
Schein, OD1
Wasson, PJ1
Boruchoff, SA1
Aronson, SB1
Moore, TE1
Macdonald, A1
Levy, I1
Holt-Wilson, AD1
Shilling, J1
Gornig, H1
Chignell, AH1
Chesterton, JR1
Thomsitt, J1
Willis, WE1
Laibson, PR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Steroids for Corneal Ulcers Trial[NCT00324168]Phase 4500 participants (Actual)Interventional2006-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Best Hard Contact Lens Corrected Visual Acuity Measured in logMAR, Correcting for Best Spectacle Corrected Visual Acuity at Enrollment

LogMAR (logarithm of the Minimum Angle of Resolution) is a measure of visual acuity in which the smaller values indicate better visual acuity. (NCT00324168)
Timeframe: 3 months from enrollment

InterventionlogMAR (Mean)
Steroid0.42
Placebo0.41

Best Spectacle-corrected Visual Acuity (BSCVA) in logMAR at 12 Months, Using Best Spectacle-corrected Enrollment Visual Acuity as a Co-variate

LogMAR (logarithm of the Minimum Angle of Resolution) is a measure of visual acuity in which the smaller values indicate better visual acuity. (NCT00324168)
Timeframe: 12 months from enrollment

InterventionlogMAR (Mean)
Steroid2.90
Placebo2.87

Best Spectacle-corrected Visual Acuity (BSCVA) in logMAR at 3 Months, Using Best Spectacle-corrected Enrollment Visual Acuity as a Co-variate

LogMAR (logarithm of the Minimum Angle of Resolution) is a measure of visual acuity in which the smaller values indicate better visual acuity. (NCT00324168)
Timeframe: 3 months from enrollment

InterventionlogMAR (Mean)
Steroid0.48
Placebo0.49

Best Spectacle-corrected Visual Acuity (BSCVA) in logMAR Using MIC (Minimum Inhibitory Concentration) to Moxifloxacin as a Covariate

Best spectacle-corrected visual acuity (BSCVA) for this outcome is measured in logMAR (logarithm of the Minimum Angle of Resolution) in which smaller values indicate better visual acuity. Minimum inhibitory concentration (MIC) to moxifloxacin was measured by E test and a log2-transformation of MIC was used in all analyses. In this analysis we add MIC to the model examining BSCVA at 3 months. (NCT00324168)
Timeframe: 3 months after enrollment

InterventionlogMAR (Mean)
Steroid0.50
Placebo0.46

Infiltrate/Scar Size, Correcting for Infiltrate/Scar Size at Enrollment

(NCT00324168)
Timeframe: 3 months from enrollment

Interventionmm (Mean)
Steroid3.07
Placebo3.02

Ocular Perforations

(NCT00324168)
Timeframe: At the time of perforation

Interventionparticipants (Number)
Steroid7
Placebo8

Time to Resolution of Epithelial Defect

This outcome measured time from enrollment to resolution of the epithelial defect in days for up to 21 days. For three weeks patients were examined every 3 days for size of epithelial defect until the defect was gone. (NCT00324168)
Timeframe: From enrollment up to 21 days

Interventiondays (Mean)
Steroid9.77
Placebo9.43

Subgroup Analysis of Best Spectacle-corrected Visual Acuity (BSCVA) by Categories of Infiltrate Depth

BSCVA measured in logMAR will be examined by categories infiltrate depth (categorized by depth percentage) by mean and standard deviation as well as in a regression model. (NCT00324168)
Timeframe: 3 months from enrollment

,
InterventionlogMAR (Mean)
>0-33%>33%-67%>67%-100%
Placebo0.260.470.86
Steroid0.350.520.80

Subgroup Analysis Predicting 3 Month Best Spectacle-corrected Visual Acuity (BSCVA) by Causative Organism

BSCVA measured in logMAR will be estimated by causative organism (either Nocardia spp, Streptococcus pneumoniae, Moraxella spp, or Pseudomonas aeruginosa). BSCVA will be examined for each causative organism by mean and standard deviation as well as in a regression model. (NCT00324168)
Timeframe: 3 months after enrollment

,
InterventionlogMAR (Mean)
Nocardia sppStreptococcus pneumoniaeMoraxella sppPseudomonas aeruginosa
Placebo0.360.520.260.45
Steroid0.540.490.460.53

Subgroup Analysis Predicting 3 Month Best Spectacle-corrected Visual Acuity (BSCVA) by Visual Acuity Group

Best spectacle-corrected visual acuity (BSCVA) for this subgroup analysis was measured in logMAR and then categorized by equivalent Snellen fractions (NCT00324168)
Timeframe: 3 months from enrollment

,
InterventionlogMAR (Mean)
<20/4020/40 to 20/800Counting fingers (CF) or worse
Placebo-0.020.381.15
Steroid0.060.361.00

Subgroup Analysis Predicting Best Spectacle-corrected Visual Acuity (BSCVA) as Stratified by Categories of Infiltrate/Scar Size

Best-spectacle visual acuity (BSCVA) at 3 months from enrollment is stratified by categories of infiltrate/scar size and examined by treatment arm (NCT00324168)
Timeframe: 3 months from enrollment

,
InterventionlogMAR (Mean)
0-1.90 mm1.91-2.70 mm2.71-4.06 mm4.07-8.90 mm
Placebo0.190.290.530.96
Steroid0.180.390.530.85

Reviews

2 reviews available for prednisolone and Corneal Ulcer

ArticleYear
Mooren's-type ulceration associated with severe hidradenitis suppurativa: a case report and literature review.
    Ocular immunology and inflammation, 2011, Volume: 19, Issue:5

    Topics: Amnion; Antibodies, Monoclonal; Aza Compounds; Conjunctiva; Corneal Perforation; Corneal Ulcer; Derm

2011
Staphylococcal blepharitis.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1977, Volume: 95, Issue:5

    Topics: Anti-Bacterial Agents; Blepharitis; Chronic Disease; Conjunctivitis; Corneal Diseases; Corneal Ulcer

1977

Trials

16 trials available for prednisolone and Corneal Ulcer

ArticleYear
Emerging moxifloxacin resistance in Pseudomonas aeruginosa keratitis isolates in South India.
    Ophthalmic epidemiology, 2013, Volume: 20, Issue:3

    Topics: Anti-Bacterial Agents; Aza Compounds; Communicable Diseases, Emerging; Cornea; Corneal Ulcer; Double

2013
The steroids for corneal ulcers trial (SCUT): secondary 12-month clinical outcomes of a randomized controlled trial.
    American journal of ophthalmology, 2014, Volume: 157, Issue:2

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Aza Compounds; Bacteria; Corneal Ulcer; Doubl

2014
Visual recovery in treated bacterial keratitis.
    Ophthalmology, 2014, Volume: 121, Issue:6

    Topics: Adult; Aged; Anti-Bacterial Agents; Aza Compounds; Corneal Ulcer; Eye Infections, Bacterial; Female;

2014
Visual outcomes in treated bacterial keratitis: four years of prospective follow-up.
    Investigative ophthalmology & visual science, 2014, May-02, Volume: 55, Issue:5

    Topics: Adult; Aged; Anti-Bacterial Agents; Aza Compounds; Corneal Ulcer; Double-Blind Method; Eye Infection

2014
Corticosteroids for bacterial corneal ulcers.
    The British journal of ophthalmology, 2009, Volume: 93, Issue:2

    Topics: Adult; Aged; Corneal Ulcer; Double-Blind Method; Epithelium, Corneal; Eye Infections, Bacterial; Fea

2009
The steroids for corneal ulcers trial: study design and baseline characteristics.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2012, Volume: 130, Issue:2

    Topics: Administration, Topical; Adult; Anti-Infective Agents; Aza Compounds; Bacteria; Cornea; Corneal Ulce

2012
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT).
    Archives of ophthalmology (Chicago, Ill. : 1960), 2012, Volume: 130, Issue:2

    Topics: Administration, Topical; Adult; Anti-Infective Agents; Aza Compounds; Bacteria; Cornea; Corneal Ulce

2012
Pseudomonas aeruginosa keratitis: outcomes and response to corticosteroid treatment.
    Investigative ophthalmology & visual science, 2012, Jan-25, Volume: 53, Issue:1

    Topics: Adult; Anti-Infective Agents; Aza Compounds; Corneal Ulcer; Double-Blind Method; Eye Infections, Bac

2012
Nocardia keratitis: clinical course and effect of corticosteroids.
    American journal of ophthalmology, 2012, Volume: 154, Issue:6

    Topics: Administration, Topical; Adult; Anti-Infective Agents; Aza Compounds; Corneal Ulcer; Double-Blind Me

2012
Prior elicitation and Bayesian analysis of the Steroids for Corneal Ulcers Trial.
    Ophthalmic epidemiology, 2012, Volume: 19, Issue:6

    Topics: Administration, Topical; Anti-Infective Agents; Aza Compounds; Bayes Theorem; Corneal Ulcer; Double-

2012
Fluoroquinolone treatment and susceptibility of isolates from bacterial keratitis.
    JAMA ophthalmology, 2013, Volume: 131, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Aza Compounds; Bacteria; Corneal Ulcer; Double-Blind Method; Drug Resi

2013
Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis.
    Investigative ophthalmology & visual science, 2013, Feb-28, Volume: 54, Issue:2

    Topics: Administration, Topical; Anti-Infective Agents; Aza Compounds; Bacteria; Corneal Ulcer; Disease Susc

2013
Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine.
    Ophthalmology, 2008, Volume: 115, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Corne

2008
Does in vitro susceptibility predict clinical outcome in bacterial keratitis?
    American journal of ophthalmology, 2008, Volume: 145, Issue:3

    Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Corneal Ulcer; Disease Susceptibility; Eye Infection

2008
[Animal experiment and clinical studies of the use of anti-inflammatory agents in chemical burns of the eye].
    Klinische Monatsblatter fur Augenheilkunde, 1988, Volume: 193, Issue:4

    Topics: Animals; Burns, Chemical; Corneal Ulcer; Dexamethasone; Eye Burns; Female; Humans; Indomethacin; Mal

1988
The aetiology and treatment of marginal corneal ulcers.
    Transactions of the ophthalmological societies of the United Kingdom, 1971, Volume: 91

    Topics: Chromones; Corneal Ulcer; Cromolyn Sodium; Humans; Ointments; Ophthalmic Solutions; Oxyphenbutazone;

1971

Other Studies

53 other studies available for prednisolone and Corneal Ulcer

ArticleYear
Customised crescentic corneal transplant with conjunctival resection in an atypical case of malignant Mooren's ulcer.
    BMJ case reports, 2017, Jul-17, Volume: 2017

    Topics: Corneal Transplantation; Corneal Ulcer; Humans; Male; Prednisolone; Slit Lamp Microscopy; Treatment

2017
Impact of topical corticosteroid pretreatment on susceptibility of the injured murine cornea to Pseudomonas aeruginosa colonization and infection.
    Experimental eye research, 2019, Volume: 179

    Topics: Administration, Ophthalmic; Animals; Cornea; Corneal Injuries; Corneal Ulcer; Disease Models, Animal

2019
Immunosuppression for Mooren's ulcer: evaluation of the stepladder approach--topical, oral and intravenous immunosuppressive agents.
    The British journal of ophthalmology, 2013, Volume: 97, Issue:11

    Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents; Corneal Ulcer; Dose-Respons

2013
Medical management of Alternaria keratitis with endophthalmitis in a patient with a corneal graft.
    Clinical & experimental ophthalmology, 2014, Volume: 42, Issue:5

    Topics: Administration, Oral; Administration, Topical; Adult; Alternaria; Alternariosis; Antifungal Agents;

2014
Man with blurry vision.
    JAMA ophthalmology, 2014, Volume: 132, Issue:6

    Topics: Anterior Chamber; Combined Modality Therapy; Contact Lenses; Corneal Ulcer; Diabetes Complications;

2014
Herpes zoster stromal keratitis after varicella vaccine booster in a pediatric patient.
    Cornea, 2014, Volume: 33, Issue:9

    Topics: Administration, Topical; Chickenpox Vaccine; Child; Corneal Stroma; Corneal Ulcer; Female; Glucocort

2014
Sodium hypochlorite chemical burn in an endodontist's eye during canal treatment using operating microscope.
    Journal of endodontics, 2014, Volume: 40, Issue:8

    Topics: Accidents, Occupational; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agents;

2014
An Adult Case of Fulminant Mumps Keratitis With Positive Viral RNA in Aqueous Humor Detected by RT-PCR.
    Cornea, 2016, Volume: 35, Issue:4

    Topics: Administration, Oral; Administration, Topical; Aqueous Humor; Betamethasone; Corneal Ulcer; Eye Infe

2016
Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis.
    Cornea, 2016, Volume: 35, Issue:9

    Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; Chloramphenicol; Combined Modality Therapy; C

2016
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis.
    Journal of pediatric ophthalmology and strabismus, 2016, Dec-08, Volume: 53

    Topics: Adolescent; Arthritis, Reactive; Corneal Stroma; Corneal Ulcer; Diagnosis, Differential; Eye Pain; G

2016
Recurrence of peripheral ulcerative keratitis on the corneoscleral button in a young man treated successfully with oral corticosteroids.
    Cornea, 2008, Volume: 27, Issue:7

    Topics: Administration, Oral; Adult; Amnion; Anti-Infective Agents; Ciprofloxacin; Corneal Transplantation;

2008
VIP promotes resistance in the Pseudomonas aeruginosa-infected cornea by modulating adhesion molecule expression.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:11

    Topics: Animals; Cell Adhesion Molecules; Cell Movement; Corneal Ulcer; Disease Models, Animal; Enzyme-Linke

2010
Intraocular invasion by microsporidial spores in a case of stromal keratitis.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:4

    Topics: Acyclovir; Adult; Biguanides; Corneal Stroma; Corneal Ulcer; Drug Therapy, Combination; Endothelium,

2011
Peripheral ulcerative keratitis after cataract surgery in a patient with ocular cicatricial pemphigoid.
    Cornea, 2011, Volume: 30, Issue:10

    Topics: Aged, 80 and over; Cataract; Combined Modality Therapy; Corneal Ulcer; Female; Glucocorticoids; Huma

2011
Peripheral ulcerative keratitis in a child.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2011, Volume: 15, Issue:5

    Topics: Child; Corneal Ulcer; Eye Pain; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrex

2011
Bilateral herpes simplex keratitis presenting as peripheral ulcerative keratitis.
    Cornea, 2012, Volume: 31, Issue:5

    Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Corneal Ulcer; Diagnosis, Differential; Drug Therapy,

2012
Bilateral Fusarium oxysporum keratitis after laser in situ keratomileusis.
    Journal of cataract and refractive surgery, 2012, Volume: 38, Issue:11

    Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Corneal Ulcer; DNA, Fungal; Drug Therapy, Combi

2012
Improvement in corneal scarring following bacterial keratitis.
    Eye (London, England), 2013, Volume: 27, Issue:3

    Topics: Adult; Aged; Aza Compounds; Cicatrix; Corneal Ulcer; Eye Infections, Bacterial; Female; Fluoroquinol

2013
CORTICOSTEROIDS EXACERBATE OCULAR HERPES SIMPLEX.
    The Medical journal of Australia, 1964, Dec-12, Volume: 2

    Topics: Administration, Topical; Adolescent; Adrenal Cortex Hormones; Betamethasone; Corneal Ulcer; Drug The

1964
ORBITAL INVOLVEMENT IN RIEDEL'S THYROIDITIS.
    The British journal of ophthalmology, 1965, Volume: 49

    Topics: Corneal Ulcer; Drug Therapy; Eye Manifestations; Humans; Orbit; Pathology; Prednisolone; Thyroiditis

1965
A comparison of invasive and cytotoxic Pseudomonas aeruginosa strain-induced corneal disease responses to therapeutics.
    Current eye research, 2003, Volume: 27, Issue:5

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cornea; Corneal Ulcer; Disease Models, Anim

2003
Bilateral phacofragmentation in a New Zealand fur seal (Arctocephalus forsteri).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2004, Volume: 35, Issue:1

    Topics: Animals; Atropine; Cataract Extraction; Corneal Edema; Corneal Ulcer; Fur Seals; Male; Mydriatics; P

2004
Late-onset idiopathic diffuse lamellar keratitis after laser in situ keratomileusis.
    Journal of cataract and refractive surgery, 2005, Volume: 31, Issue:2

    Topics: Administration, Topical; Astigmatism; Corneal Ulcer; Female; Glucocorticoids; Humans; Keratomileusis

2005
Proflavine and light in the treatment of experimental herpetic ocular infections.
    Antimicrobial agents and chemotherapy, 1974, Volume: 6, Issue:5

    Topics: Animals; Corneal Ulcer; Drug Therapy, Combination; Idoxuridine; Keratitis, Herpetic; Male; Photochem

1974
Corneal perforation due to severe peripheral ulcerative keratitis in Crohn disease.
    Cornea, 2006, Volume: 25, Issue:5

    Topics: Aged; Combined Modality Therapy; Conjunctiva; Corneal Ulcer; Crohn Disease; Glucocorticoids; Humans;

2006
Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis.
    Cornea, 2006, Volume: 25, Issue:8

    Topics: Anti-Bacterial Agents; Cefazolin; Child; Conjunctivitis, Allergic; Corneal Ulcer; Cyclopentolate; Dr

2006
Unusual eye signs in Wegener's granulomatosis.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2007, Volume: 13, Issue:3

    Topics: Anti-Inflammatory Agents; Corneal Ulcer; Cyclophosphamide; Female; Granulomatosis with Polyangiitis;

2007
Peripheral ulcerative keratitis with bilateral optic nerve involvement as an initial presentation of acute lymphocytic leukemia in an adult.
    International ophthalmology, 2009, Volume: 29, Issue:1

    Topics: Adult; Corneal Ulcer; Drug Therapy, Combination; Female; Fluoroquinolones; Gatifloxacin; Humans; Int

2009
Combined therapy for vernal shield ulcer.
    Clinical & experimental optometry, 2008, Volume: 91, Issue:1

    Topics: Adult; Conjunctivitis, Allergic; Corneal Ulcer; Cyclosporine; Drug Therapy, Combination; Follow-Up S

2008
Focal degeneration of the cornea with sequestration in a cat.
    Journal of the American Veterinary Medical Association, 1966, Nov-01, Volume: 149, Issue:9

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Atropine; Cat Diseases; Cats; Chloramphe

1966
Effects of prednisolone and medroxyprogesterone on corneal wound healing, ulceration, and neovascularization.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1983, Volume: 101, Issue:4

    Topics: Animals; Collagen; Cornea; Corneal Injuries; Corneal Ulcer; Medroxyprogesterone; Medroxyprogesterone

1983
Corticosteroids and corneal epithelial wound healing.
    The British journal of ophthalmology, 1982, Volume: 66, Issue:11

    Topics: Animals; Cornea; Corneal Ulcer; Dexamethasone; Epithelium; Female; Glucocorticoids; Male; Prednisolo

1982
Herpetic ocular infections of childhood.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1980, Volume: 98, Issue:4

    Topics: Adolescent; Atropine; Child; Child, Preschool; Corneal Ulcer; Drug Resistance, Microbial; Female; Fo

1980
Prednisolone acetate or prednisolone phosphate concurrently administered with ciprofloxacin for the therapy of experimental Pseudomonas aeruginosa keratitis.
    Current eye research, 1993, Volume: 12, Issue:5

    Topics: Animals; Aqueous Humor; Ciprofloxacin; Corneal Ulcer; Disease Models, Animal; Drug Therapy, Combinat

1993
Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome.
    Cornea, 1996, Volume: 15, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Administration, Oral; Adult; Anti-Inflammatory Agents

1996
Endophthalmitis associated with microbial keratitis.
    Ophthalmology, 1996, Volume: 103, Issue:11

    Topics: Anti-Inflammatory Agents; Bacteria; Corneal Ulcer; Endophthalmitis; Eye Infections, Bacterial; Eye I

1996
Sympathetic ophthalmia associated with antecedent adherent leucoma--a rare association.
    Acta ophthalmologica Scandinavica, 1998, Volume: 76, Issue:3

    Topics: Administration, Oral; Adult; Corneal Opacity; Corneal Ulcer; Dexamethasone; Glucocorticoids; Humans;

1998
Peripheral ulcerative keratitis after Salmonella gastroenteritis.
    Cornea, 1998, Volume: 17, Issue:6

    Topics: Aged; Cornea; Corneal Neovascularization; Corneal Ulcer; Cyclopentolate; Drug Therapy, Combination;

1998
The treatment of Pseudomonas keratoscleritis after pterygium excision.
    Cornea, 1999, Volume: 18, Issue:5

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Corneal Ulcer; Debridement; Drug Therapy, Combina

1999
Role of ocular matrix metalloproteinases in peripheral ulcerative keratitis.
    The British journal of ophthalmology, 1999, Volume: 83, Issue:12

    Topics: Copper; Cornea; Corneal Ulcer; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Eye; Gelatin

1999
Oral pemphigus vulgaris preceding cutaneous lesions: recognition and diagnosis.
    Journal of the American Dental Association (1939), 2000, Volume: 131, Issue:8

    Topics: Adult; Aged; Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Corneal Ulcer; Cyclophosphamide

2000
The effect of local and systemic steroids on healing of corneal wounds.
    Bulletin of the Ophthalmological Society of Egypt, 1976, Volume: 69, Issue:73

    Topics: Administration, Topical; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Anti-Inflamm

1976
Recurrent keratitis due to Acremonium potronii.
    American journal of ophthalmology, 1975, Volume: 79, Issue:1

    Topics: Adolescent; Atropine; Bacitracin; Corneal Injuries; Corneal Ulcer; Cyanoacrylates; Eye Injuries; Gen

1975
Recurrent suppurative kerato-uveitis with loss of eye due to infection by Acanthamoeba castellani.
    Transactions of the ophthalmological societies of the United Kingdom, 1975, Volume: 95, Issue:2

    Topics: Amebiasis; Anti-Bacterial Agents; Corneal Transplantation; Corneal Ulcer; Doxycycline; Eukaryota; Hu

1975
Recurrence of herpetic stromal keratitis after a conjunctival flap surgical procedure.
    American journal of ophthalmology, 1992, Aug-15, Volume: 114, Issue:2

    Topics: Aged; Cataract Extraction; Conjunctiva; Corneal Stroma; Corneal Ulcer; Eye Infections, Viral; Female

1992
[A patient with temporal arteritis presenting corneal ulcer as his first symptom].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1989, Volume: 78, Issue:5

    Topics: Aged; Corneal Ulcer; Cyclophosphamide; Drug Therapy, Combination; Giant Cell Arteritis; Humans; Male

1989
Peripheral corneal ulcer associated with benign hypergammaglobulinemic purpura.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1988, Volume: 23, Issue:5

    Topics: Corneal Ulcer; Female; Humans; Hydrocortisone; Keratitis; Middle Aged; Plasmapheresis; Prednisolone;

1988
Microbial keratitis associated with contaminated ocular medications.
    American journal of ophthalmology, 1988, Apr-15, Volume: 105, Issue:4

    Topics: Administration, Topical; Aged; Aged, 80 and over; Corneal Ulcer; Drug Contamination; Female; Humans;

1988
Corticosteroid therapy in central stromal keratitis.
    American journal of ophthalmology, 1969, Volume: 67, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Aged; Antibody Formation; Antigen-Antibody Reactions; Bacteria; Chil

1969
Erythrodermic psoriasis with corneal ulcers and ophthalmological sequelae.
    Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:8

    Topics: Adult; Beds; Corneal Ulcer; Dermatitis, Exfoliative; Female; Humans; Methotrexate; Panophthalmitis;

1971
[Topical prednisolone therapy of corneal ulcers].
    Zeitschrift fur arztliche Fortbildung, 1972, Feb-15, Volume: 66, Issue:4

    Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Corneal Ulcer; Female; Follow-Up Stu

1972
Marginal ulceration of the cornea.
    The British journal of ophthalmology, 1970, Volume: 54, Issue:7

    Topics: Adolescent; Adult; Aged; Corneal Ulcer; Eye; Eye Foreign Bodies; Female; Humans; Male; Middle Aged;

1970
Intractable Mycobacterium fortuitum corneal ulcer in man.
    American journal of ophthalmology, 1971, Volume: 71, Issue:2

    Topics: Accidents, Occupational; Anti-Bacterial Agents; Antitubercular Agents; Chronic Disease; Corneal Ulce

1971