prednisolone and Colitis Gravis studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Research Excerpts

Excerpt	Relevance	Reference
"The local release of human neutrophil lipocalin, considered to be highly specific for neutrophil granulocyte activation, and interleukin-8 and tumor necrosis factor-alpha were studied in 11 patients with distal ulcerative colitis and proctitis before and during treatment with steroid enemas."	7.71	Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis. ( Carlson, M; Lööf, L; Raab, Y; Sangfelt, P; Thörn, M; Xu, S, 2002)
"We describe the response of symptoms of chronic abacterial prostatitis/chronic pelvic pain syndrome (CAP/PPS) in a man treated with rectal prednisolone for concomitant ulcerative colitis."	7.71	Variability of the symptoms of chronic abacterial prostatitis/chronic pelvic pain syndrome during intermittent therapy with rectal prednisolone foam for ulcerative colitis. ( Bates, S; Talbot, M, 2001)
" Two young adult women are described in whom headache and papilloedema in association with raised intracranial pressure occurred during prednisolone treatment for inflammatory bowel disease."	7.69	Benign intracranial hypertension during prednisolone treatment for inflammatory bowel disease. ( Cooper, BT; Newton, M, 1994)
"A double blind trial of prednisolone suppositories in out-patients with idiopathic proctitis is reported."	7.64	A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis. ( BARON, JH; CONNELL, AM; JONES, FA; LENNARD-JONES, JE, 1962)
"It is concluded that in the topical treatment of ulcerative colitis, BDP may be preferable to PP because it exerts a promising anti-inflammatory action without affecting adrenocortical function."	6.66	Comparison of beclomethasone dipropionate (2 and 3 mg) and prednisolone sodium phosphate enemas (30 mg) in the treatment of ulcerative proctitis. An adrenocortical approach. ( Endert, E; Houthoff, HJ; Mulder, CJ; Tytgat, GN; van der Heide, H; Wiersinga, W; Wiltink, EH, 1989)
"The patient was diagnosed with ulcerative colitis and received remission induction therapy with prednisolone."	5.51	Hematemesis due to Drug Allergy to Oral Prednisolone in a Patient with Ulcerative Colitis. ( Arisaka, O; Arisaka, T; Hiraishi, H; Irisawa, A; Kanazawa, M; Sugaya, T; Takahashi, F; Takenaka, K; Tominaga, K, 2019)
"A 19-year-old Japanese man had been treated for ulcerative colitis for 2 years."	5.37	A case of acne fulminans in a patient with ulcerative colitis successfully treated with prednisolone and diaminodiphenylsulfone: a literature review of acne fulminans, rosacea fulminans and neutrophilic dermatoses occurring in the setting of inflammatory ( Danno, K; Fujimoto, N; Tanaka, T; Uenishi, T; Wakabayashi, M, 2011)
"Colitis was induced by intrarectal administration of OXA solution (7."	5.32	Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. ( Hatakeyama, S; Kojima, R; Kuroda, S; Nakamaru, K; Ohkishi, T, 2004)
"Patients were eligible if they had acute disease with a modified Truelove and Witts activity score of more than 10 for at least 2 weeks and if they were currently not receiving immunomodulators or more than 10 mg/day prednisolone."	5.11	Infliximab for acute, not steroid-refractory ulcerative colitis: a randomized pilot study. ( Göke, B; Ochsenkühn, T; Sackmann, M, 2004)
" Based on these findings, we diagnosed him with eosinophilic gastroenteritis and started prednisolone."	3.96	Eosinophilic Gastroenteritis in an Ulcerative Colitis Patient During Treatment with Tumor Necrosis Factor-alpha Antagonist. ( Amano, N; Genda, T; Hayashida, S; Ikeda, Y; Murata, A; Nagahara, A; Sato, S; Shimada, Y; Takahashi, S; Tsuzura, H, 2020)
" Intravenous administration of prednisolone was initiated on suspicion of lacrimal gland inflammation (pseudotumor)."	3.76	Case of lacrimal gland inflammation associated with ulcerative colitis. ( Katsumura, N; Mochizuki, K; Sawada, A, 2010)
"The local release of human neutrophil lipocalin, considered to be highly specific for neutrophil granulocyte activation, and interleukin-8 and tumor necrosis factor-alpha were studied in 11 patients with distal ulcerative colitis and proctitis before and during treatment with steroid enemas."	3.71	Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-alpha is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis. ( Carlson, M; Lööf, L; Raab, Y; Sangfelt, P; Thörn, M; Xu, S, 2002)
"We describe the response of symptoms of chronic abacterial prostatitis/chronic pelvic pain syndrome (CAP/PPS) in a man treated with rectal prednisolone for concomitant ulcerative colitis."	3.71	Variability of the symptoms of chronic abacterial prostatitis/chronic pelvic pain syndrome during intermittent therapy with rectal prednisolone foam for ulcerative colitis. ( Bates, S; Talbot, M, 2001)
"High doses of orally administered prednisolone induced the healing of the pyoderma gangrenosum within 2 months."	3.70	[Extra-intestinal manifestations and complications in chronic active ulcerative colitis in childhood and adolescence]. ( Hüppe, D; Schenck, B; Tromm, A, 1999)
"We report a rare case of ulcerative colitis (UC) associated with methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa infections in multiple organs, and with compressive fracture from osteoporosis after the administration of high-dose prednisolone and azathioprine."	3.70	Severe complications of ulcerative colitis after high-dose prednisolone and azathioprine treatment. ( Abo, Y; Kawamura, YJ; Masaki, T; Matsuda, K; Muto, T; Uchida, H; Watanabe, T, 1999)
" The course of the disease and the shape of the lesions strongly suggested involvement of rheumatoid vasculitis; oral administration of prednisolone was effective."	3.70	Rheumatoid arthritis accompanied by colonic lesions. ( Matake, H; Matsui, T; Matsumura, M; Nagahama, T; Sakurai, T; Schlemper, R; Tsuda, S; Yao, T, 2000)
" Two young adult women are described in whom headache and papilloedema in association with raised intracranial pressure occurred during prednisolone treatment for inflammatory bowel disease."	3.69	Benign intracranial hypertension during prednisolone treatment for inflammatory bowel disease. ( Cooper, BT; Newton, M, 1994)
"A rat model of colitis [dextran sulfate (DSS)] was used to study the permeation of Evans blue (EB) from the lumen into the wall of proximal and distal colonic loops after exposure to the dye for 2 hr."	3.69	Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats. ( Ahlman, H; Björck, S; Dahlström, A; Jennische, E, 1997)
" Low birth weight were observed after the medication of prednisolone and a manifestation of the ulcerous colitis during the gravidity."	3.68	[Pregnancy and chronic inflammatory bowel diseases]. ( Hänert, E; Schneider, W, 1991)
"A double blind trial of prednisolone suppositories in out-patients with idiopathic proctitis is reported."	3.64	A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis. ( BARON, JH; CONNELL, AM; JONES, FA; LENNARD-JONES, JE, 1962)
"In active ulcerative colitis [UC] refractory to mesalazine, escalation to either steroids or immunosuppression is common practice."	2.90	Novel Leucocyte/Thrombocyte Apheresis for Induction of Steroid-Free Remission in Ulcerative Colitis: A Controlled Randomized Pilot Study. ( Dignaß, A; Drebber, U; Kruis, W; Morgenstern, J; Nguyen, P; Ramlow, W; Stallmach, A, 2019)
"In patients with steroid-dependent ulcerative colitis, 6-month therapy with low dose of dexamethasone 21-phosphate allowed the withdrawal of oral steroids and the reversal of steroid-related adverse events in most patients while maintaining clinical remission (ClinicalTrials."	2.78	Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. ( Andriulli, A; Annese, V; Bossa, F; Damonte, G; De Santo, E; Latiano, A; Magnani, M; Martino, G; Palmieri, O; Rossi, L; Serafini, S; Valvano, MR, 2013)
" Seven patients received a single topical dose of 30 mg and one special case subject received three doses with 4 weeks between dosing occasions."	2.78	Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity. ( Admyre, C; Löfberg, R; Lutfi, T; Malek, M; Musch, E; von Stein, OD; von Stein, P; Zargari, A, 2013)
"Vidofludimus (SC12267) is a novel oral immunomodulator inhibiting dihydroorotate dehydrogenase (DHODH) and the expression of proinflammatory cytokines including interleukin-17 (IL17A and IL17F) and interferon-gamma."	2.78	Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: the ENTRANCE study. ( Ammendola, A; Diculescu, M; Dietrich, B; Fellermann, K; Hartmann, H; Hentsch, B; Herrlinger, KR; Howaldt, S; Nikolov, R; Otte, JM; Petrov, A; Reindl, W; Stange, EF; Stoynov, S; Strauch, U; Sturm, A; Voiosu, R, 2013)
" However, a significantly higher incidence of adverse event (AE) was observed in the routine 3,000 mL LCAP group as compared with the BWA-LCAP group (P < 0."	2.76	Optimal apheresis treatment volume for the efficacy and safety of leukocytapheresis with Cellsorba in patients with active ulcerative colitis. ( Fukunaga, K; Hida, N; Iimuro, M; Kamikozuru, K; Kato, K; Kikuyama, R; Matsumoto, T; Miwa, H; Nagase, K; Nakamura, S; Ohda, Y; Takeda, N; Yokoyama, Y; Yoshida, K, 2011)
"6-Mercaptopurine (6-MP) is an effective maintenance medication in patients with ulcerative colitis (UC), but toxic effects like myelosuppression limit its clinical benefit."	2.75	Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide. ( Abe, J; Arai, O; Hanai, H; Hosoda, Y; Iida, T; Ikeya, K; Kageoka, M; Kubota, T; Maruyama, Y; Miwa, I; Oohata, A; Takeuchi, K; Watanabe, F; Yoshirou, S, 2010)
"The study included 44 patients with ulcerative colitis (UC), which was implemented MSC transplantation, 40 patients with UC who received standard therapy with mesalazane (salofalka) 4-6 g/day and corticosteroids (prednisone)--1-2 mg/kg, azathioprine--1."	2.75	[Allogeneic mesenchymal stromal cells in patients with ulcerative colitis: two years of observation]. ( Gudkova, RB; Khomeriki, SG; Kniazev, OV; Konopliannikov, AG; Konopliannikova, OA; Lazebnik, LB; Mikhaĭlova, ZF; Parfenov, AI; Rogozina, VA; Ruchkina, IN; Shcherbakov, PL; Tsaregorodtseva, TM, 2010)
" UC patients whose neutrophils were isolated were divided into two subgroups according to their total preoperative dosage of prednisolone: group H, > or =10,000 mg; group L, <10,000 mg."	2.73	Neutrophil-related immunoinflammatory disturbance in steroid-overdosed ulcerative colitis patients. ( Araki, T; Kusunoki, M; Miki, C; Okita, Y; Uchida, K; Yoshiyama, S, 2008)
"Ulcerative colitis is characterized by relapsing mucosal inflammation where the lesions include tissue-damaging granulocytes."	2.73	The proinflammatory CXC-chemokines GRO-alpha/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids. ( Bjartell, A; Carlson, M; Egesten, A; Eliasson, M; Erjefält, JS; Olin, AI; Sangfelt, P, 2007)
"Heparin could be beneficial to the treatment of active ulcerative colitis because of its anticoagulant, anti-inflammatory and immunomodulatory properties."	2.72	Low-molecular-weight heparin (enoxaparin) as adjuvant therapy in the treatment of active ulcerative colitis: a randomized, controlled, comparative study. ( Evgenidis, N; Giouleme, O; Nikolaidis, N; Papageorgiou, A; Papaioannou, G; Patsiaoura, K; Vassiliadis, T; Zezos, P, 2006)
" Therefore, an alternative treatment is necessary in order to decrease steroid dosage and avoid the clinical problems associated with steroids."	2.71	Multicenter randomized controlled trial for the treatment of ulcerative colitis with a leukocytapheresis column. ( Asakura, H; Hibi, T; Hiwatashi, N; Muto, T; Nagawa, H; Satomi, M; Sawada, K; Sawada, T; Shimoyama, T, 2003)
"Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis."	2.71	Oral prednisolone metasulphobenzoate in the treatment of active ulcerative colitis. ( Balan, K; Binnie, JA; Cameron, EA; Middleton, SJ; Skerratt, SA; Solanki, C; Swift, A, 2003)
"Azathioprine has a useful role in maintaining the remission achieved by i."	2.71	Combination immunomodulatory therapy with cyclosporine and azathioprine in corticosteroid-resistant severe ulcerative colitis: the Edinburgh experience of outcome. ( Campbell, S; Ghosh, S, 2003)
"Prednisolone was gradually stopped and sulfasalazine was maintained."	2.71	Different therapy for different types of ulcerative colitis in China. ( Cui, HF; Jiang, XL, 2004)
"Active ulcerative colitis (UC) is often associated with increased peripheral granulocytes and monocytes/macrophages which show activation behavior and prolonged survival time."	2.71	Adsorptive granulocyte and monocyte apheresis versus prednisolone in patients with corticosteroid-dependent moderately severe ulcerative colitis. ( Hanai, H; Iida, T; Iwaoka, Y; Kikuch, K; Maruyama, Y; Matsushita, I; Saniabadi, AR; Sato, Y; Takeuchi, K; Tanaka, T; Tozawa, K; Watanabe, F; Yamada, M, 2004)
"Steroid administration currently plays a central role in the medical management of ulcerative colitis (UC); however, long-term steroid usage causes adverse effects, which necessitates stoppage of drug intake, leading to worsening of the disease."	2.71	Leukocytapheresis therapy for steroid-naïve patients with active ulcerative colitis: its clinical efficacy and adverse effects compared with those of conventional steroid therapy. ( Abe, T; Aoyama, N; Fukagawa, M; Kasuga, M; Maekawa, S; Nakahara, T; Nishioka, C; Shirasaka, D; Tamura, T; Umezu, M, 2005)
"Nicotine enemas cause fewer AEs and were used as supplemental treatment for active UC."	2.71	A randomized trial of nicotine enemas for active ulcerative colitis. ( Courtney, E; Evans, BK; Green, JT; Hawkes, ND; Ingram, JR; Newcombe, RG; Pillai, S; Rhodes, J; Srivastava, ED; Swift, JL; Thomas, GA; Williams, GT, 2005)
"Sixteen ulcerative colitis patients received IFN-alpha-2A subcutaneously (dosage: first wk, 9 MIU three times weekly [t."	2.70	An open-labeled, randomized study comparing systemic interferon-alpha-2A and prednisolone enemas in the treatment of left-sided ulcerative colitis. ( Davidsen, B; Federspiel, B; Madsen, SM; Munkholm, P; Nielsen, OH; Riis, P; Schlichting, P, 2001)
"Ulcerative colitis is managed mainly in secondary care by regular outpatient reviews done by specialist clinicians."	2.70	Guided self-management and patient-directed follow-up of ulcerative colitis: a randomised trial. ( Roberts, C; Robinson, A; Thompson, DG; Wilkin, D, 2001)
"Forty-two patients with severe ulcerative colitis (more than 10 points on the Powell-Tuck scoring system and mucosal disease Heatly grade III or IV)."	2.70	Octreotide in patients with active ulcerative colitis treated with high dose corticosteroids (OPUS 1). ( Friis, S; Hoogkamer, JF; Karvonen, AL; Lygren, I; Mulder, CJ; Nielsen, OH; Rädler, A; Tefera, S; van Bergeijk, JD; von Tirpitz, C; Waldum, HL; Wilson, JH, 2002)
"Patients with active ulcerative colitis have decreased levels of factor XIII (FXIII) activity, which is important for woundhealing."	2.69	Lack of clinical efficacy of additional factor XIII treatment in patients with steroid refractory colitis. The Factor XIII Study Group. ( Andus, T; Bregenzer, N; Caesar, I; Hämling, J; Malchow, H; Schölmerich, J; Schreiber, S, 1999)
"Azathioprine (AZA) has been shown to be effective and safe in the treatment of chronic active UC."	2.69	Mycophenolate mofetil versus azathioprine in patients with chronic active ulcerative colitis: a 12-month pilot study. ( Galle, PR; Krummenauer, F; Mayet, WJ; Neurath, MF; Orth, T; Peters, M; Schlaak, JF; Wanitschke, R, 2000)
"In the first, 24 patients with severe ulcerative colitis (UC) were prospectively studied by the Research Group of Inflammatory Bowel Disease, sponsored by the Ministry of Health and Welfare of Japan."	2.68	Corticosteroids for the management of ulcerative colitis. ( Kitano, A; Kobayashi, K; Matsumoto, T; Oshitani, N, 1995)
"Prednisolone treated patients had significantly fewer days with liquid stools than mesalazine patients, with a median of 0 and 1 days respectively by week 4 (p = 0."	2.68	A randomised trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis. ( Daniels, S; Grace, RH; Jewell, DP; Keighley, MR; Kingston, RD; Lee, FI; Mani, V; Patterson, J; Record, CO; Smith, K, 1996)
"Ulcerative colitis is largely a disease of non-smokers."	2.68	Transdermal nicotine compared with oral prednisolone therapy for active ulcerative colitis. ( Feyerabend, C; Mani, V; Newcombe, RG; Ragunath, K; Rhodes, J; Russell, MA; Thomas, GA; Williams, GT, 1996)
"One hundred patients with active ulcerative colitis, not reaching beyond the splenic flexure as determined by endoscopy, were treated for up to 8 weeks."	2.67	Budesonide versus prednisolone retention enemas in active distal ulcerative colitis. ( Danielsson, A; Graffner, H; Langholz, E; Löfberg, R; Matzen, P; Møller-Petersen, JF; Ostergaard Thomsen, O; Påhlman, L; Schiöler, R; Suhr, O, 1994)
"The etiology of Crohn's disease remains unknown, but current research has concentrated on autoimmunity and/or mycobacterial infection."	2.67	Mycobacterium paratuberculosis in intestinal tissue from patients with Crohn's disease demonstrated by a nested primer polymerase chain reaction. ( Andersen, J; Binder, V; Engbaek, K; Lisby, G, 1994)
"Prednisolone was given in a dose of 40 mg daily orally, reducing over four weeks to 10 or 20 mg."	2.67	Double blind trial of oral fluticasone propionate v prednisolone in the treatment of active ulcerative colitis. ( Burke, DA; Giaffer, MH; Hawkey, CJ; Hawthorne, AB; Holdsworth, CD; Keech, ML; Record, CO, 1993)
"The effect of fish oil on the course of ulcerative colitis was investigated in a randomised blinded controlled study."	2.67	Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. ( Belluzzi, A; Daneshmend, TK; Everitt, SJ; Hawkey, CJ; Hawthorne, AB; Holmes, GK; Malkinson, C; Shaheen, MZ; Willars, JE, 1992)
"It is concluded that in the topical treatment of ulcerative colitis, BDP may be preferable to PP because it exerts a promising anti-inflammatory action without affecting adrenocortical function."	2.66	Comparison of beclomethasone dipropionate (2 and 3 mg) and prednisolone sodium phosphate enemas (30 mg) in the treatment of ulcerative proctitis. An adrenocortical approach. ( Endert, E; Houthoff, HJ; Mulder, CJ; Tytgat, GN; van der Heide, H; Wiersinga, W; Wiltink, EH, 1989)
"26 in-patients (17 with Crohn's disease, 9 with ulcerative colitis) were given high-molecular (diet 1; 12 patients) or low-molecular (diet 2; 14 patients) elemental diets (6."	2.66	[Adjuvant therapy with elemental diet in chronic inflammatory intestinal diseases. Comparative study]. ( Heskamp, R; Rabast, U, 1986)
"Sixty-four patients with active distal ulcerative colitis participated in a multicentre, randomized, investigator-blind trial to compare the effect of budesonide enema, 2 mg/100 ml, with prednisolone disodium phosphate enema, 31."	2.66	A controlled randomized trial of budesonide versus prednisolone retention enemas in active distal ulcerative colitis. ( Danielsson, A; Hellers, G; Löfberg, R; Lyrenäs, E; Naesdal, J; Nilsson, A; Olsson, O; Olsson, SA; Persson, T; Salde, L, 1987)
" In view of the low plasma prednisolone concentrations obtained, there are theoretical advantages in using a poorly absorbed enema to avoid the possibility of systemic steroid effects in patients requiring long term steroid treatment."	2.66	Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis. ( Berghouse, L; English, J; Lennard-Jones, JE; Macrae, FA; McIntyre, PB, 1985)
" Treatment with steroid enemas resulted in symptomatic and sigmoidoscopic evidence of improvement more frequently than treatment with a dosage of oral steroid calculated to achieve similar plasma prednisolone levels."	2.65	A comparison of prednisolone enemas with low-dose oral prednisolone in the treatment of acute distal ulcerative colitis. ( Axon, AT; Dickinson, RJ; Dixon, MF; Hamilton, I; Pinder, IF; Ruddell, WS, 1984)
"It is concluded that maintenance treatment of ulcerative colitis with sulphasalazine should be continued indefinitely unless contraindicated by side effects."	2.64	A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin). ( Dissanayake, AS; Truelove, SC, 1973)
"In the case of steroid resistance in ulcerative colitis, aminosalicylates, the above-mentioned immunomodulators, infliximab, adalimumab or calcineurin inhibitors such as ciclosporin or tacrolimus may be administered."	2.48	Therapy of steroid-resistant inflammatory bowel disease. ( Frei, P; Lakatos, PL; Manz, M; Rogler, G; Safroneeva, E; Schoepfer, AM; Vavricka, SR; Wanner, R, 2012)
"Tracheobronchitis is a rare extraintestinal manifestation of ulcerative colitis (UC) and is often mis-diagnosed and treated as asthma."	2.45	A case of tracheobronchitis in ulcerative colitis: a review of literature. ( Kar, S; Thomas, SG, 2009)
" We also evaluated the effectiveness and side effects of prednisolone using chitosan capsules compared with the conventional dosage form (gelatin capsules)."	2.44	[Study on the colon specific delivery of prednisolone using chitosan capsules]. ( Yamamoto, A, 2007)
"Surgical indication for ulcerative colitis is fulminant colitis, intractability, cancer or dysplasia."	2.43	[Surgical treatment for ulcerative colitis--recent advances]. ( Arai, K; Fukushima, T; Kimura, H; Kitoh, F; Koganei, K; Shimada, H; Sugita, A, 2005)
"Guidelines for treatment of ulcerative colitis in children have been created by the working group of the Japanese Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Japanese Society for Pediatric Inflammatory Bowel Disease."	2.43	[Guidelines for treatment of ulcerative colitis in children]. ( Tomomasa, T, 2005)
"In patients with moderate to severe ulcerative colitis whose disease was refractory to conventional treatment using corticosteroids and/or immunosuppressive agents, infliximab (three intravenous infusions at 0, 2, and 6 weeks) was more effective than placebo in inducing clinical remission (Relative Risk (RR) 3."	2.43	Tumour necrosis factor alpha blocking agents for induction of remission in ulcerative colitis. ( Akobeng, AK; Lawson, MM; Thomas, AG, 2006)
"She had ulcerative colitis when she was 16 and received medical treatment."	2.43	[A case of sacroiliitis complicated by ulcerative colitis that was successfully treated with steroid]. ( Araki, A; Chin, S; Itsui, Y; Kanai, T; Kawamura, T; Kubota, D; Matsumoto, T; Miyata, T; Ohoka, S; Okada, E; Sakamoto, N; Tsuchiya, K; Watanabe, M, 2006)
"Crohn's disease and ulcerative colitis are the most frequent inflammatory bowel diseases (IBD) with a prevalence of approximately one out of 500."	2.42	[Inflammatory bowel diseases (IBD) -- critical discussion of etiology, pathogenesis, diagnostics, and therapy]. ( Göke, B; Ochsenkühn, T; Sackmann, M, 2003)
"It describes the treatment of ulcerative colitis according to the different groups of patients and the degree of activity."	2.41	[Conservative therapy of inflammatory bowel diseases]. ( Nagy, F, 2002)
"A case of Basedow's disease, that developed after successful treatment of ulcerative colitis with a total colectomy, is presented, along with a review of the Japanese literature on the coexistence of hyperthyroidism and ulcerative colitis."	2.41	Basedow's disease and chronic ulcerative colitis: a case report and review of the Japanese literature. ( Hada, T; Iijima, H; Moriwaki, Y; Nishimura, M; Takahashi, S; Yamamoto, T, 2001)
"The role of salicylates in Crohn's disease is limited to the mild activity phase; further data are required to clarify its role in maintenance on remission."	2.41	New steroids and new salicylates in inflammatory bowel disease: a critical appraisal. ( Campieri, M, 2002)
"Drugs for the treatment of ulcerative colitis are sulphapyridine, 5-aminosalicylic acid, prednisolone, betamethasone and immunosuppressive drugs."	2.40	[Ulcerative colitis and intestinal bleeding]. ( Asakura, H, 1998)
"In patients with moderate or severe ulcerative colitis, glucocorticoids which may be given in conjunction with SASP or 5-ASA are beneficial in producing remission."	2.40	[Medical therapy in ulcerative colitis]. ( Akiya, T; Kon, Y; Motegi, K; Nagasako, K; Nogawa, H; Sawada, T, 1999)
"Selection of treatment for ulcerative colitis is based on the definition of clinical severity."	2.40	[Treatment of mild and moderate ulcerative colitis]. ( Fujinuma, S; Nakajima, S; Sakai, K; Sakai, Y, 1999)
"Ocular complications in ulcerative colitis has been reviewed."	2.40	[Ocular complications in ulcerative colitis]. ( Harada, T, 1999)
"Women with ulcerative colitis who are pregnant have many concerns, such as the effect of the gestational period on UC, the effect of UC on the pregnancy, and the safety of drugs used to control the disease."	2.40	[Ulcerative colitis and pregnancy]. ( Ida, A; Koyama, K, 1999)
"An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described."	2.38	Polymyositis associated with ulcerative colitis. ( Chawla, YK; Chugh, S; Dang, N; Dilawari, JB; Radotra, BD; Sawhney, IM, 1993)
"The reported incidence of Crohn's disease has increased in the last 30 years."	2.37	Chronic inflammatory bowel disease. ( Sanderson, IR, 1986)
"The modern medical and surgical treatment of ulcerative colitis has been detailed."	2.35	The management of ulcerative colitis. ( Watkinson, G, 1976)
"Aseptic abscesses associated with ulcerative colitis are difficult to differentiate from infectious abscesses."	1.91	Multiple ulcerative colitis-associated aseptic abscesses successfully treated with infliximab: a case report. ( Fujii, K; Fujimoto, A; Hojo, A; Ikegami, R; Matsuda, T; Nogami, A; Ogawa, Y; Toba, T; Watanabe, N, 2023)
"Pediatric ulcerative colitis is likely to be more severe than adult ulcerative colitis."	1.91	A pediatric case of infliximab-resistant ulcerative colitis successfully treated using vedolizumab. ( Fukura, S; Ichihara, Y; Kondo, S; Mori, K; Ono, A; Shichijo, K; Suzuki, Y; Takei, M; Takeuchi, S; Tayama, T, 2023)
"A 56-year-old Japanese man with ulcerative colitis and a history of Sweet's syndrome who was taking prednisolone and azathioprine presented with a moderate exacerbation of ulcerative colitis, abdominal pain, diarrhea, and bloody stools along with cytomegalovirus infection."	1.91	Ulcerative colitis successfully treated with vedolizumab in the presence of comorbid opportunistic infections: a case report. ( Ichimori, T; Ishikawa, Y; Nagano, S; Oki, Y; Uchida, K; Yamada, T, 2023)
"However, the efficacy and safety of treatment of severe colitis is poorly understood."	1.72	Safety and efficacy of infliximab and corticosteroid therapy in checkpoint inhibitor-induced colitis. ( Abed, OK; Agnholt, JS; Bjerrum, JT; Dahl, EK; Dige, A; Donia, M; Kjeldsen, J; Seidelin, JB; Svane, IM, 2022)
"001), with increases in poorly bioavailable oral corticosteroids in Crohn's (pandemic 15."	1.72	Treatment adaptations and outcomes of patients experiencing inflammatory bowel disease flares during the early COVID-19 pandemic: the PREPARE-IBD multicentre cohort study. ( Bhala, N; Brookes, MJ; Conley, TE; Gonzalez, HA; Hicks, LC; Kennedy, NA; Kent, AJ; Lamb, CA; Mehta, SJ; Patel, KV; Saifuddin, A; Sebastian, S; Segal, JP; Subramanian, S; Walker, GJ, 2022)
"Steroids are one of the main treatments for ulcerative colitis; however, steroids work well for only about 50% of people who take them."	1.72	Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods study. ( Barr, A; Bedford, H; Blackwell, S; Coates, E; Dames, N; Hind, D; Lee, M; Lobo, A; Probert, C; Sebastian, S; Shackley, P; Totton, N; Wickramasekera, N, 2022)
"A woman in her 30s was diagnosed with ulcerative colitis (UC) 4 years ago and treated with tacrolimus, azathioprine, and prednisolone 5mg (PSL)."	1.72	[Ulcerative colitis complicated by pyoderma gangrenosum and multiple aseptic abscesses]. ( Hashimoto, Y; Hosaka, H; Itoi, Y; Kasuga, K; Kita, A; Kuribayashi, S; Sato, K; Tanaka, H; Uraoka, T, 2022)
"In total, 391 patients with ulcerative colitis who received ileal pouch-anal anastomosis were identified."	1.72	Risk factors for failure of ileal pouch-anal anastomosis in patients with refractory ulcerative colitis. ( Frese, JP; Gröne, J; Konietschke, F; Kreis, ME; Lauscher, JC; Seifarth, C, 2022)
"The onset age of ulcerative colitis has been increasing in several countries."	1.62	Clinical Course of Ulcerative Colitis Associated with an Age at Diagnosis: A Recent Japanese Database Survey. ( Iijima, K; Shimodaira, Y; Watanabe, K, 2021)
" Mesalazine at 4,000 mg/day and prednisolone at 60 mg/day were started, and the prednisolone dosage was thereafter gradually reduced and switched to golimumab."	1.62	Multiple Cerebral Infarction Associated with Cerebral Vasculitis in a Patient with Ulcerative Colitis. ( Dohi, O; Hasegawa, D; Hirose, R; Inoue, K; Ishikawa, T; Itoh, Y; Kamada, K; Konishi, H; Naito, Y; Takagi, T; Uchiyama, K; Yasuda, T; Yoshida, N, 2021)
"The therapy of linear IgA dermatosis is ensured by steroid-containing topical agents, alongside antiseptic measures as well as systemic dapsone p."	1.51	["Decoratively figured blisters" on the whole integument in initially diagnosed ulcerative colitis]. ( Daeschlein, G; Jünger, M; Konschake, W; Lutze, S, 2019)
"The patient was diagnosed with ulcerative colitis and received remission induction therapy with prednisolone."	1.51	Hematemesis due to Drug Allergy to Oral Prednisolone in a Patient with Ulcerative Colitis. ( Arisaka, O; Arisaka, T; Hiraishi, H; Irisawa, A; Kanazawa, M; Sugaya, T; Takahashi, F; Takenaka, K; Tominaga, K, 2019)
"Prednisolone treatment successfully induced clinical remission and mucosal healing."	1.51	A case of nivolumab-associated colitis, which relapsed after mucosal healing and was then successfully treated with mesalazine. ( Akemoto, Y; Asari, T; Chinda, D; Fukuda, S; Fukutoku, Y; Hasui, K; Hiraga, H; Kikuchi, H; Mikami, T; Murai, Y; Sakuraba, H; Sawaya, M; Tanaka, M; Tatsuta, T, 2019)
"Budesonide with multi-matrix technology (MMX) is an oral corticosteroid, shown to have high topical activity against ulcerative colitis (UC) while maintaining low systemic bioavailability with few adverse events."	1.48	Budesonide with multi-matrix technology as second-line treatment for ulcerative colitis: evaluation of long-term cost-effectiveness in the Netherlands. ( Ghatnekar, O; Gherardi, A; Kuijvenhoven, J; Roze, S; Yip Sonderegger, YL, 2018)
" Conclusion We confirmed that LI-CAP has therapeutic effects on reducing the dosage and discontinuing steroids in patients with steroid-dependent UC."	1.46	Long-interval Cytapheresis as a Novel Therapeutic Strategy Leading to Dosage Reduction and Discontinuation of Steroids in Steroid-dependent Ulcerative Colitis. ( Etou, T; Iizuka, M; Kumagai, M; Matsuoka, A; Numata, Y; Sagara, S, 2017)
"When he developed ulcerative colitis in the following year, he also noticed wasting of the calf muscles."	1.46	Non-granulomatous myositis in a patient with ulcerative colitis who showed symptoms resembling gastrocnemius myalgia syndrome. ( Hamano, T; Inoue, M; Shibata, Y; Tachibana, N; Tsuzaki, K; Yamamoto, M, 2017)
"He had ulcerative colitis that was diagnosed 10 years previously which was well controlled on adalimumab 40 mg fortnightly."	1.46	Oral Sweet's syndrome occurring in ulcerative colitis. ( Nestor, LA; Tobin, AM, 2017)
"She had poorly controlled ulcerative colitis and was treated with high doses of prednisolone, infliximab, acetaminophen and lansoprazole."	1.43	Toxic epidermal necrolysis caused by acetaminophen featuring almost 100% skin detachment: Acetaminophen is associated with a risk of severe cutaneous adverse reactions. ( Aruga, T; Fukuda, K; Kamiyama, T; Kobayashi, K; Miyake, Y; Sasaki, S; Sueki, H; Watanabe, H, 2016)
"Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical syndrome of varying etiologies with similar neuroimaging findings."	1.43	Reversible Posterior Leukoencephalopathy Syndrome Associated with Treatment for Acute Exacerbation of Ulcerative Colitis. ( Ashida, T; Kikuchi, S; Maemoto, A; Orii, F, 2016)
"A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy."	1.42	Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions. ( Chayama, K; Hayashi, R; Nagai, K; Sagami, S; Tanaka, S; Ueno, Y, 2015)
"As seen in active ulcerative colitis (UC), the formation of crypt abscesses was observed in the biopsy."	1.42	A case of diverticular colitis with lesions resembling ulcerative colitis and correlation of tumor necrosis factor-alpha staining with clinical manifestations. ( Inui, K; Katano, Y; Kobayashi, T; Kosaka, T; Torii, Y; Wakabayasi, T; Yoshino, J, 2015)
"She was under treatment for ulcerative colitis."	1.42	[Case of posterior reversible encephalopathy syndrome due to azathioprine]. ( Kanno, S; Mochizuki, H; Ogawa, R; Oikawa, T; Shibuya, S; Shijo, T, 2015)
"A 16-years old man with severe ulcerative colitis (UC) was admitted to our hospital."	1.42	A rare case of ulcerative colitis exacerbated by VZV infection. ( Fujikawa, Y; Nishimura, S; Watanabe, M; Yazumi, S; Yoshino, T, 2015)
"Monitoring active ulcerative colitis (UC) is essential for making correct and timely treatment decisions."	1.40	The correlation between fecal calprotectin, simple clinical colitis activity index and biochemical markers in ulcerative colitis during high-dose steroid treatment. ( Kiszka-Kanowitz, M; Nielsen, AM; Nordgaard-Lassen, I; Theede, K, 2014)
"Patients with ulcerative colitis still need effective therapy without major side effects."	1.40	Strontium chloride: can it be a new treatment option for ulcerative colitis? ( Akyol, M; Ataseven, H; Topal, F; Tuzcu, M; Tuzcu, N; Yonem, O, 2014)
"Prednisolone has been gradually reduced."	1.40	Florid urticarial vasculitis heralding a flare up of ulcerative colitis. ( Boules, E; Lyon, C, 2014)
"Patients with ulcerative colitis (UC) are treated with prednisolone (PSL), which causes adverse side effects."	1.39	Efficacy, safety and cost analyses in ulcerative colitis patients undergoing granulocyte and monocyte adsorption or receiving prednisolone. ( Hiraishi, H; Hoshino, M; Kanke, K; Nakano, M; Tominaga, K, 2013)
"Currently available drugs for the treatment of ulcerative colitis (UC) include salicylates, thiopurines, corticosteroids and new anti-tumour necrosis factor (TNF)-α biologics."	1.39	Treatment of children and adolescents with ulcerative colitis by adsorptive depletion of myeloid lineage leucocytes as monotherapy or in combination with low dose prednisolone after failure of first-line medications. ( Akagi, M; Goishi, H; Kajihara, T; Miura, T; Sugiyama, S; Tanaka, T, 2013)
"We report a case of a patient with ulcerative colitis and central serous retinopathy, which is a chronic ophthalmological condition that is frequently aggravated by corticosteroid treatment and may sometimes result in severe visual impairment."	1.39	A patient with ulcerative colitis and central serous chorioretinopathy--a therapeutic dilemma. ( Ben-Horin, S; Geyshis, B; Katz, G; Kopylov, U, 2013)
" There was a significant difference in the dosage of steroid per month just before colectomy between the two groups (P = 0."	1.39	Characteristics of extremely early-onset pouchitis after proctocolectomy with ileal pouch-anal anastomosis. ( Araki, T; Fujikawa, H; Inoue, M; Inoue, Y; Kawamura, M; Kusunoki, M; Mohri, Y; Okita, Y; Shimura, T; Tanaka, K; Uchida, K, 2013)
"She was diagnosed with unilateral hypoglossal nerve palsy, which was thought to be caused by mononeuritis."	1.38	Ulcerative colitis associated with isolated unilateral hypoglossal nerve palsy. ( Doi, K; Fukuba, N; Fukuda, K; Ishihara, S; Kawashima, K; Kinoshita, Y; Kusunoki, R; Ohno, Y; Oka, A; Onishi, K; Tada, Y; Uemura, Y; Yuki, T, 2012)
"We report a rare case of lobular panniculitis with small vessel vasculitis, presenting with fever, cutaneous lesions, and systemic manifestations involving the visceral fat and associated with ulcerative colitis."	1.37	Lobular panniculitis with small vessel vasculitis associated with ulcerative colitis. ( Almerigogna, F; Beccastrini, E; Emmi, G; Emmi, L; Nesi, G; Squatrito, D, 2011)
"A 19-year-old Japanese man had been treated for ulcerative colitis for 2 years."	1.37	A case of acne fulminans in a patient with ulcerative colitis successfully treated with prednisolone and diaminodiphenylsulfone: a literature review of acne fulminans, rosacea fulminans and neutrophilic dermatoses occurring in the setting of inflammatory ( Danno, K; Fujimoto, N; Tanaka, T; Uenishi, T; Wakabayashi, M, 2011)
"There was a significant positive correlation between the levels of MIF and the total preoperative dosage of prednisolone."	1.37	Neutrophil dysfunction in steroid-overdosed patients with ulcerative colitis: potential relevance of macrophage migration inhibitory factor to increased postoperative morbidity. ( Araki, T; Kusunoki, M; Miki, C; Okita, Y; Otake, K; Uchida, K; Yoshiyama, S, 2011)
"We describe a pediatric case of Sweet syndrome presenting 10 days after treatment with azathioprine."	1.37	Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis. ( Choe, YH; Jang, KT; Kim, MJ, 2011)
"A case of hemophagocytic syndrome associated with ulcerative colitis is very rare."	1.36	[A case of hemophagocytic syndrome in an ulcerative colitis patient]. ( Cheung, DY; Hong, SI; Kim, GM; Kim, JI; Kim, JK; Kim, YC; Lee, HS; Park, SH, 2010)
"Fourteen members of the Japanese Society for Pediatric Inflammatory Bowel Disease reported 35 retrospective cases that received AZA/6-MP and were evaluated for adverse drug effects."	1.35	Efficacy and safety of azathioprine and 6-mercaptopurine in Japanese pediatric patients with ulcerative colitis: a survey of the Japanese Society for Pediatric Inflammatory Bowel Disease. ( Etani, Y; Kobayashi, A; Konno, M; Maisawa, S; Nakacho, M; Sasaki, M; Shimizu, T; Sumazaki, R; Tajiri, H; Tomomasa, T; Toyoda, S; Ushijima, K; Yoden, A, 2008)
"We present a case of ulcerative colitis in a pediatric liver transplant recipient."	1.35	De novo inflammatory bowel disease after pediatric orthotopic liver transplant: a case report. ( Bahador, A; Dehghani, SM; Eshraghian, A; Geramizadeh, B; Kakaei, F; Malek-Hosseini, SA, 2009)
"A total of 58 patients with ulcerative colitis (UC, N = 37) or Crohn's disease (CD, N = 21) together with 11 healthy controls were included in this study."	1.35	Adsorptive depletion of elevated proinflammatory CD14+CD16+DR++ monocytes in patients with inflammatory bowel disease. ( Hanai, H; Hirayama, K; Iida, T; Iwaoka, Y; Kikuyama, M; Maruyama, Y; Nagata, S; Takai, K; Takeuchi, K; Watanabe, F; Yamada, M, 2008)
"A 62-year-old Japanese woman with ulcerative colitis (UC) had episcleritis and erythema nodosum."	1.35	[Episcleritis and erythema nodosum in a patient with ulcerative colitis]. ( Kanda, K; Kihara, Y; Kume, K; Maekawa, S; Otsuki, M; Tashiro, M; Yamasaki, M; Yoshikawa, I, 2008)
"Fifty consecutive patients with active ulcerative colitis initially received five granulocyte, monocyte/macrophage adsorptive apheresis sessions with the Adacolumn over five consecutive weeks."	1.34	Factors affecting clinical and endoscopic efficacies of selective leucocytapheresis for ulcerative colitis. ( Maruyama, Y; Matsumoto, K; Saniabadi, AR; Umegae, S; Yamamoto, T, 2007)
"Both ulcerative colitis and multiple sclerosis were eventually well controlled using this regimen."	1.34	Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a. ( Baumgart, DC; Paul, F; Rudolph, B; Schott, E; Wiedenmann, B; Wuerfel, JT; Zipp, F, 2007)
"Colonic biopsies from patients with ulcerative colitis and normal controls were cultured with either budesonide or prednisolone in the presence of proinflammatory cytokines."	1.33	Effect of corticosteroids on nitric oxide production in inflammatory bowel disease: are leukocytes the site of action? ( Kolios, G; Linehan, JD; Robertson, DA; Valatas, V; Westwick, J, 2005)
"The histology was consistent with ulcerative colitis."	1.33	Development of ulcerative colitis after heart transplantation during immunosuppressive therapy. ( Böhm, M; Ecker, KW; Giese, T; Jüngling, B; Kindermann, I; Moser, C; Püschel, W; Schäfers, HJ; Stallmach, A; Zeuzem, S, 2005)
"We describe a patient with ulcerative colitis (UC) who developed small vessel vasculitis."	1.33	Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis. ( Grigoriadou, M; Magira, E; Panani, AD; Raptis, SA; Roussos, C, 2006)
"Ulcerative colitis-related interstitial lung disease is exceedingly rare and has been reported to be steroid-responsive."	1.33	Case report: Fatal acute exacerbation of usual interstitial pneumonia in ulcerative colitis. ( Engelke, C; Fend, F; Hautmann, H; Kremer, M; Marten, K; Rummeny, EJ, 2005)
"Ulcerative colitis (UC) and Crohn's disease (CD) are characterized by intestinal inflammation mainly caused by a disturbance in the balance between cytokines and increased complement (C) activation."	1.33	Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis. ( Baatrup, G; Dahlerup, JF; Grønbaek, H; Thorlacius-Ussing, O; Zimmermann-Nielsen, E, 2005)
"She had been diagnosed and treated for ulcerative colitis for four years."	1.33	Cerebral arteriopathy with extracranial artery involvement in a patient with ulcerative colitis. ( Hirabayashi, K; Katayama, Y; Katsura, K; Nagao, T; Nomoto, T; Seta, T; Yokochi, M, 2006)
"We report on a 30-year-old male with ulcerative colitis who developed a spontaneous gas gangrene in the right limb, the gluteal muscles and the retroperitoneal region under immunosuppressive therapy."	1.33	[Gas gangrene with ulcerative colitis under immunosuppressive therapy: report of a case]. ( Freitag, M; Jackisch, T; Ludwig, K, 2006)
"Ten subjects with active ulcerative colitis and 13 subjects with active Crohn's disease were recruited."	1.33	Repeat planar white cell scanning to monitor short-term therapy of active inflammatory bowel disease: a methodological study and comparison with clinical scores and novel inflammatory markers. ( Britten, AJ; Dearing, M; Gordon, C; Heenan, S; Irwin, AG; Maxwell, JD; Poullis, A, 2006)
"A 22-year-old woman with ulcerative colitis developed skin eruptions, liver dysfunction, and atypical lymphocytes in the peripheral blood two weeks after she started taking salazosulfapyridine (SASP)."	1.32	Salazosulfapyridine induced hypersensitivity syndrome associated with reactivation of humanherpes virus 6. ( Goto, H; Kitagawa, K; Kunisaki, Y; Nagano, M, 2003)
"We report a patient with ulcerative colitis who, in the period following surgery, developed recurrent episodes of acute adrenal insufficiency presenting clinically as a high output ileostomy."	1.32	Acute adrenal insufficiency presenting as high output ileostomy. ( Hemingway, D; Rai, S, 2003)
"Prednisolone (40 mg) was prescribed to 15 patients with severe disease activity."	1.32	Correlation between circulating soluble ICAM-1 and prednisolone-induced amelioration of ulcerative colitis. ( Nielsen, OH; Vainer, B, 2003)
" This case suggests that combining ECCT with steroid therapy can maintain such poorly controlled and high-risk UC patients safely for the scheduled colectomy while improving the prognosis by reducing the dosage of steroid efficiently prior to operation."	1.32	Poorly controlled ulcerative colitis treated by colectomy during remission induced by extracorporeal leukocyte removal therapy. ( Fukuda, Y; Fukui, S; Fukunaga, K; Hori, K; Matoba, Y; Ohnishi, K; Sagayama, K; Sawada, K; Shimoyama, T, 2003)
"Prednisolone was effective."	1.32	Pulseless hematochezia: Takayasu's arteritis associated with ulcerative colitis. ( Arakaki, T; Hokama, A; Kawane, M; Kinjo, F; Koja, K; Makishi, T; Matayoshi, R; Saito, A; Sunagawa, T; Tomiyama, R; Yonamine, Y, 2003)
"Previous clinical features of ulcerative colitis, activity index at four weeks, and subsequent course were compared between patients with leukocytapheresis and those without."	1.32	Addition of leukocytapheresis to steroid therapy: is it beneficial in recurrence of moderate-to-severe ulcerative colitis? ( Iida, M; Jo, Y; Matsumoto, T; Mibu, R, 2003)
"A 19-year-old man with severe active ulcerative colitis was admitted to our hospital where he was prescribed 80 mg prednisolone and underwent leukocytapheresis (LCAP)."	1.32	Cerebral sinus thrombosis associated with severe active ulcerative colitis. ( Date, H; Eto, T; Inatsu, H; Ishikawa, N; Kitani, M; Murata, S; Ootsuka, M; Oshikawa, S; Yamaga, J, 2004)
"The aetiology of bone loss in ulcerative colitis is multifactorial, but corticosteroid treatment is an important risk factor."	1.32	The short-term effects of Eudragit-L-coated prednisolone metasulphobenzoate (Predocol) on bone formation and bone mineral density in acute ulcerative colitis. ( Darlow, SJ; Mandal, A; Mayberry, JF; Pick, B; Robinson, RJ; Thomas, T, 2004)
"Colitis was induced by intrarectal administration of OXA solution (7."	1.32	Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. ( Hatakeyama, S; Kojima, R; Kuroda, S; Nakamaru, K; Ohkishi, T, 2004)
"Twenty-six patients (14 ulcerative colitis, 12 Crohn's disease) were included."	1.32	Granulocyteaphaeresis in steroid-dependent inflammatory bowel disease: a prospective, open, pilot study. ( Bastida, G; Domènech, E; Esteve-Comas, M; Gassull, MA; Gomollón, F; Herrera, JM; Hinojosa, J; Obrador, A; Ruiz, R; Saro, C, 2004)
"Pre-treatment with prednisolone decreased the cell attracting effect of ICAM-1 in a dose-dependent manner to 72% of the basal migration (P<0."	1.31	Chemotactic properties of ICAM-1 and PECAM-1 on neutrophil granulocytes in ulcerative colitis: effects of prednisolone and mesalazine. ( Nielsen, OH; Vainer, B, 2000)
"Thirty-nine patients with IBD (22 with ulcerative colitis, 17 with Crohn's disease) and 35 normal controls were studied."	1.31	Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease. ( Buttgereit, F; Lochs, H; Rohde, W; Schottelius, A; Schreiber, S; Wedel, S; Weltrich, R, 2000)
"We report a case of refractory ulcerative colitis treated with tacrolimus."	1.31	Tacrolimus in corticosteroid-resistant ulcerative colitis. ( Iwadare, JI; Komeno, Y; Kondo, K; Matsuhashi, N; Muto, T; Nagawa, H; Nakajima, A; Ohnishi, S; Omata, M; Suzuki, A; Usui, Y; Watanabe, K; Watanabe, T, 2000)
"Ursodeoxycholic acid (UDCA) treatment for primary sclerosing cholangitis (PSC) has been considered a rational therapy, though its effectiveness in the clinical course is still open to discussion."	1.31	Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis. ( Kikuchi, S; Kisara, N; Komatsu, K; Maruhama, Y; Shimosegawa, T; Toyota, T; Uchi, M; Ueno, Y, 2000)
"Ulcerative colitis is an inflammatory bowel disease with chronic diarrhea, rectal bleeding and characteristic histological findings."	1.31	Nephronophthisis and ulcerative colitis in siblings: a new association. ( Ala-Mello, S; Kääriäinen, H; Koskimies, O, 2001)
"We have developed a new experimental ulcerative colitis model in rats."	1.31	[The new experimental ulcerative colitis model in rats induced by subserosal injection of acetic acid]. ( Hamamoto, S; Iwadate, K; Kojima, R; Moriwaki, M; Ohwaki, T, 2001)
"Retroperitoneal fibrosis has been described as a rare occurrence during the course of inflammatory bowel disease, mainly Crohn's disease."	1.31	Retroperitoneal fibrosis during the course of ulcerative colitis. A simple coincidence? ( Anezinis, P; Karampekios, S; Koulentaki, M; Kouroumalis, EA; Matrella, E; Mouzas, IA, 2001)
"A case of ulcerative colitis complicated by Wilson's disease is described."	1.31	A rare case of ulcerative colitis complicating Wilson's disease: possible association between the two diseases. ( Azuma, K; Esaki, M; Iida, M; Matsumoto, T; Nakamura, S; Okada, M; Torisu, T; Tsuji, H; Yao, T, 2002)
"Hypertrophic cardiomyopathy has been described in preterms treated with dexamethasone for bronchopulmonary dysplasia."	1.30	[Hypertrophic cardiomyopathy complicating a prolonged corticotherapy for hemorrhagic rectocolitis]. ( Cézard, JP; Faure, C; Guillonneau, M; Jacqz-Aigrain, E; Lhasbellaoui, F; Magnier, S; Navarro, J, 1997)
"An 11-year-old boy with acute fulminant ulcerative colitis (UC) is presented."	1.30	Acute fulminant ulcerative colitis with toxic megacolon. ( Fujita, S; Hori, T; Igarashi, C; Tosaka, M; Yokozawa, M; Yonezawa, K; Yoshida, M; Yoshida, Y, 1997)
"Hospitalizations for ulcerative colitis occurred with similar frequency (about 15 hospitalizations per 100 patients per year) among users of those drugs."	1.30	5-Aminosalicylates, sulfasalazine, steroid use, and complications in patients with ulcerative colitis. ( Bianchi, LA; Dreyer, NA; Field, LG; Sutherland, LR; Szneke, P; Walker, AM, 1997)
"The association of sensorineural hearing loss and ulcerative colitis is well documented and it is speculated that this is autoimmune in origin."	1.30	Sensorineural hearing loss and ulcerative colitis. ( Carlin, WV; Kumar, BN; Walsh, RM; Wilson, PS, 1997)
" However, in severely relapsed cases, corticosteroids are not always effective even when a high dosage is administered."	1.30	A pilot study of centrifugal leukocyte apheresis for corticosteroid-resistant active ulcerative colitis. ( Ashida, T; Ayabe, T; Einami, K; Kohgo, Y; Nomura, M; Ono, M; Saitoh, Y; Santos, SB; Shibata, Y; Taniguchi, M; Taruishi, M, 1997)
" The occurrence of steroid side effects depends on dosage and duration of steroid treatment."	1.30	[Steroid-induced myopathy in left-sided ulcerative colitis. Successful treatment and continued therapy with the topical steroid budesonide]. ( Andus, T; Caesar, I; Gross, V; Hohenberger, W; Roth, M; Schölmerich, J, 1997)
"Eleven patients with ulcerative colitis (5 who responded to intravenous glucocorticoids and 6 who did not) and ten control subjects were studied."	1.30	Relationship between glucocorticoid receptor and response to glucocorticoid therapy in ulcerative colitis. ( Hiwatashi, N; Kinouchi, Y; Shimada, T; Toyota, T; Yamazaki, H, 1997)
"A 29-year-old man with severe aplastic anemia (SAA) was submitted to HLA-identical unrelated allogeneic bone marrow transplantation (BMT) and was found to be suffering from grade IV G-I GVHD."	1.30	Intra-mesenteric artery steroid administration relieved severe refractory gastro-intestinal graft-vs.-host disease in an allogeneic bone marrow transplantation patient. ( Honma, H; Kato, J; Kogawa, K; Kuribayashi, K; Morii, K; Nagamachi, Y; Nagaoka, Y; Niitsu, Y; Sakamaki, S; Sato, T, 1997)
"Blood was collected from patients with Crohn's disease (N = 49), ulcerative colitis (N = 43), and normal control volunteers (N = 15)."	1.30	Peripheral blood lymphocyte beta 2 integrin and ICAM expression in inflammatory bowel disease. ( Bernstein, CN; Rawsthorne, P; Rector, E; Sargent, M, 1997)
"Patients with Crohn's disease had significantly lower lumbar spine and total body BMD SDS than patients with ulcerative colitis, even after adjustment for cumulative dose of prednisolone."	1.30	Bone mineral density and nutritional status in children with chronic inflammatory bowel disease. ( Boot, AM; Bouquet, J; de Muinck Keizer-Schrama, SM; Krenning, EP, 1998)
"In both IBDs, but particularly Crohn's disease, increased activation of NF kappa B may be involved in the regulation of the inflammatory response."	1.30	Activation of nuclear factor kappa B inflammatory bowel disease. ( Hampe, J; Nikolaus, S; Schreiber, S, 1998)
"Twenty-seven patients with active ulcerative colitis and 42 with active Crohn's disease treated with glucocorticoids were studied."	1.30	Markers of coagulation and fibrinolysis as measures of disease activity in inflammatory bowel disease. ( Brandslund, I; Kjeldsen, J; Lassen, JF; Schaffalitzky de Muckadell, OB, 1998)
"Ethane breath tests were conducted on all animals on days 2, 4, 6, 8, and 10 (acute phase) and weeks 3, 6, and 9 (chronic phase) after commencement of DSS consumption."	1.30	An orally administered growth factor extract derived from bovine whey suppresses breath ethane in colitic rats. ( Butler, RN; Howarth, GS; Porter, SN, 1998)
" In addition, the long-term use of corticosteroids often causes serious side effects."	1.30	Centrifugal leukocyte apheresis for ulcerative colitis. ( Ashida, T; Ayabe, T; Kohgo, Y, 1998)
"Ulcerative colitis was controlled by administering 40 mg of predonisolone during perioperative period."	1.30	[Coronary artery bypass grafting for a patient with angina pectoris and ulcerative colitis]. ( Esato, K; Fujimura, Y; Gohra, H; Hamano, K; Ikeda, N; Katoh, T; Noda, H; Sirasawa, B; Sudoh, M, 1999)
"We describe a 31-year-old patient with ulcerative colitis who was successfully treated with prednisolone (PSL)."	1.29	Suppressed natural killer cell activity in ulcerative colitis. ( Itoh, K; Jinbo, T; Kubota, K; Matsushima, T; Murakami, H; Naruse, T; Take, H; Tamura, J; Tsuchiya, J, 1994)
"Severe acute inflammation in ulcerative colitis is often associated with major intestinal blood loss."	1.29	[Substitution of factor XIII concentrate in treatment refractory ulcerative colitis. A prospective pilot study]. ( Born, P; Classen, M; Lorenz, R, 1994)
"Two men with severe ulcerative colitis developed ulcerative tracheobronchitis 4 and 8 years after total colectomy."	1.29	Ulcerative tracheobronchitis years after colectomy for ulcerative colitis. ( McGinty, F; Vasishta, S; Wood, JB, 1994)
"Extraintestinal features of ulcerative colitis are well recognised."	1.29	Unusual pulmonary complication of ulcerative colitis with a rapid response to corticosteroids: case report. ( Chalmers, AH; Hilling, GA; Rigby, HS; Robertson, DA, 1994)
"In patients with Crohn's disease not taking corticosteroids, IgM lipocortin-I antibody levels were directly related to disease activity scored clinically."	1.29	Antibodies to human recombinant lipocortin-I in inflammatory bowel disease. ( Rampton, DS; Smith, SF; Stevens, TR, 1993)
"Treatment of acute attacks of ulcerative colitis in 89 patients with doses of prednisolone above or equal to 40 mg resulted in an overall remission in 67%."	1.29	Treatment of ulcerative colitis with high doses of oral prednisolone. The rate of remission, the need for surgery, and the effect of prolonging the treatment. ( Kjeldsen, J, 1993)
"Severely ill patients with ulcerative colitis are usually treated with parenteral corticoids."	1.29	Are antibiotics useful in the management of nontoxic severe ulcerative colitis? ( Peppercorn, MA, 1993)
"Very few cases of BOOP associated with ulcerative colitis have been reported."	1.29	[A case of bronchiolitis obliterans organizing pneumonia associated with ulcerative colitis]. ( Hirano, T; Kawabata, Y; Kondo, Y; Matsumoto, K; Suzuki, R; Takagi, K; Taki, F; Yamaki, K; Yokoi, T, 1993)
"Twenty children with active ulcerative colitis were assessed before and after 8 weeks of medical therapy with 5-aminosalicylic acid (5-ASA) derivatives and corticosteroids."	1.29	Endoscopic assessment of the colonic response to corticosteroids in children with ulcerative colitis. ( Beattie, RM; Domizio, P; Nicholls, SW; Walker-Smith, JA; Williams, CB, 1996)
"He had a previous history of selective IgA deficiency and ulcerative colitis treated with sulphasalazine."	1.29	Primary Sjögren's syndrome, ulcerative colitis and selective IgA deficiency. ( Colaco, CB; McCrea, DJ; Steuer, A, 1996)
"A case of ulcerative colitis complicated with gastric and duodenal lesions is reported."	1.29	Ulcerative colitis complicated by gastroduodenal lesions. ( Bamba, T; Fujiyama, Y; Inoue, H; Koyama, S; Okada, K; Sasaki, M; Yoshioka, U, 1996)
"A 20-year-old man with ulcerative colitis was admitted because of fever, eruption and lymphadenopathy."	1.29	Salazosulfapyridine-induced angioimmunoblastic lymphadenopathy. ( Goto, M; Hatta, K; Imanaka, T; Kobashi, Y; Nakano, A, 1996)
"In active ulcerative colitis, A23187 and antihuman IgE induced significantly higher stimulation of PAF synthesis compared to their effects on normal mucosa."	1.28	Cytokines and platelet-activating factor in human inflamed colonic mucosa. ( Eliakim, R; Karmeli, F; Ligumsky, M; Rachmilewitz, D; Simon, P, 1992)
"In patients with ulcerative colitis, the hydrophilic suppository showed retrograde spread to a site 34."	1.28	Pharmaceutical characterization of corticosteroid suppository treatment for ulcerative colitis. ( Hosoi, K; Iijima, T; Ito, Z; Noguchi, M; Sadahiro, S, 1992)
"The use of azathioprine in ulcerative colitis is unclear."	1.28	The role of azathioprine in the management of ulcerative colitis. ( Axon, AT; Burke, DA; Foster, PN; Johnston, D; Lobo, AJ, 1990)
"Miniaturised methods have been used to construct dose-response curves for the effects of inhibitory drugs on prostaglandin synthesis using individual rectal biopsies obtained from patients with ulcerative colitis."	1.27	Inhibition of prostaglandin synthetase in human rectal mucosa. ( Hawkey, CJ; Lo Casto, M, 1983)
"Although Crohn's disease may decrease fertility, female reproductive ability is normal in UC."	1.27	Medical and surgical treatment of inflammatory bowel disease in pregnancy. ( Warsof, SL, 1983)
"In two patients, treatment of amebic dysentery was followed (despite the disappearance of the infecting organism) by an illness with the clinical, pathological, and radiological characteristics of nonspecific ulcerative colitis."	1.27	Nonspecific ulcerative colitis as a sequel to amebic dysentery. ( Clark, CG; Rampton, DS; Salmon, PR, 1983)
"The pharmacokinetics and bioavailability of prednisolone after doses of oral prednisone and intravenous prednisolone were determined in seven patients receiving corticosteroids for treatment of inflammatory bowel disease in active disease and remission."	1.27	Effect of inflammatory bowel disease on absorption and disposition of prednisolone. ( George, DE; Jusko, WJ; Lebenthal, E; Milsap, RL; Murray, KA; Szefler, SJ, 1983)
"In 6 patients with ulcerative colitis absorption was delayed until the preparation reached the colon but the total absorption was unchanged."	1.27	Absorption of delayed-release prednisolone in ulcerative colitis and Crohn's disease. ( Dew, MJ; Evans, BK; Rhodes, J; Richards, A; Richards, D; Rogers, L; Thomas, P, 1985)
"In active ulcerative colitis basal platelet-activating factor activity was 8."	1.27	Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. ( Eliakim, R; Karmeli, F; Rachmilewitz, D; Razin, E, 1988)
"Prednisolone absorption was studied in 13 normal subjects, eight patients with ulcerative colitis and 21 patients with Crohn's disease, by measuring plasma levels after a single oral dose."	1.27	Prednisolone absorption in inflammatory bowel disease: correlation with anatomical site and extent. ( Lennard-Jones, JE; McIntyre, PB; Nabi, EM; Phongsathorn, V; Rodrigues, CA; Rosen, A; Spiliadis, C; Willoughby, JM, 1987)
"A young woman with ulcerative colitis developed pneumonia, which responded to corticosteroids."	1.27	Bronchiolitis obliterans organising pneumonia in a patient with ulcerative colitis. ( Ashcroft, T; Cobden, I; Corris, PA; Jackson, GJ; Morritt, GN; Swinburn, CR, 1988)
"Thirty-seven patients with ulcerative colitis who had shown inadequate response to conventional medical therapies were given intraarterial infusions of prednisolone via the superior and inferior mesenteric arteries."	1.27	Intraarterial prednisolone infusion therapy in ulcerative colitis. ( Asakura, H; Hiramatsu, K; Kohda, E; Momoshima, S, 1985)
"A patient with ulcerative colitis presenting with vasculitic purpura is reported."	1.27	A case of ulcerative colitis presenting as vasculitic purpura. ( McCarthy, CF; McDermott, V, 1985)
"Thus, ulcerative colitis can be safely controlled by medical management unless we misjudge the timing for surgical intervention."	1.27	[Indications for surgery from the point of view of an internist]. ( Watanabe, H, 1985)
" In the fulminant form of the disease the highly dosed application of prednisolone with ease the highly dosed application of prednisolone with parenteral hypercaloric nutrition and the substitution of mineral, protein and blood losses are therapeutically in the first place."	1.26	[Ulcerative and granulomatous colitis]. ( Bosseckert, H, 1981)
"The granulomatous inflammation in Crohn's disease differs from that in sarcoidosis, in which striking elevation of angiotensin-converting enzyme is present in granulomatous tissue and frequently in serum."	1.26	Angiotensin-converting enzyme in Crohn's disease and ulcerative colitis. ( Fierst, SM; Friedland, J; Silverstein, E; Simon, MR; Weinstock, JV, 1981)
"Ulcerative colitis is associated with many ocular complications."	1.26	Scleromalacia perforans in ulcerative colitis. ( Burgess, JA; Goy, JA; Lazell, RW; Tesar, PJ, 1981)
"In a 25-year old woman with ulcerative colitis a lupus erythematosus syndrome occurred during treatment with salazosulfapyridine."	1.26	[Salazosulfapyridine-induced lupus erythematosus syndrome in ulcerative colitis (author's transl)]. ( Jaup, BH, 1978)
"There were no deaths directly due to ulcerative colitis or to surgical treatment in these patients during the period of the study, the mean period of follow-up being 25 months; but 4 elderly patients died from unrelated causes."	1.26	Further experience in the treatment of severe attacks of ulcerative colitis. ( Kettlewell, MG; Lee, EG; Truelove, SC; Willoughby, CP, 1978)
"Pericarditis is an uncommon but important complication of inflammatory bowel disease."	1.26	Pericarditis and inflammatory bowel disease. ( Bown, R; Lennard-Jones, JE; Swarbrick, ET; Thompson, DG, 1979)
" The study revealed no correlation between steroid dosage and postoperative morbidity or mortality."	1.26	Factors which influenced postoperative complications in patients with ulcerative colitis or Crohn's disease of the colon on corticosteroids. ( Allsop, JR; Lee, EC, 1978)
"A young female with ulcerative colitis associated with positive direct and indirect Coombs reaction and severe autoimmune hemolytic anemia is reported."	1.26	Antibody coated red cells with and without hemolysis in chronic ulcerative colitis. ( Jacob, J; Lance, KP, 1976)
"A woman with ulcerative colitis was treated with sulphasalazine and prednisolone."	1.25	Fibrosing alveolitis and treatment with sulphasalazine. ( Davies, D; MacFarlane, A, 1974)
"In acute exacerbations of ulcerative colitis, the potential difference was reversed, the luminal side being positive."	1.25	Electrical potentials of the sigmoid colon and rectum in irritable bowel syndrome and ulcerative colitis. ( Edmonds, CJ, 1970)

Research

Studies (562)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Change in IL-17

Timeframe	Studies, this research(%)	All Research%
pre-1990	182 (32.38)	18.7374
1990's	119 (21.17)	18.2507
2000's	135 (24.02)	29.6817
2010's	103 (18.33)	24.3611
2020's	23 (4.09)	2.80

Authors	Studies
Shimodaira, Y	1
Watanabe, K	3
Iijima, K	1
Gardiner, LJ	1
Carrieri, AP	1
Bingham, K	1
Macluskie, G	1
Bunton, D	1
McNeil, M	1
Pyzer-Knapp, EO	1
Hosomi, S	1
Sugita, N	1
Kanamori, A	1
Ominami, M	1
Otani, K	1
Kamata, N	2
Tanaka, F	1
Nagami, Y	1
Taira, K	1
Fujiwara, Y	1
Irie, K	2
Tateishi, T	1
Hirano, S	1
Ueno, S	1
Kikuchi, S	3
Taniwaki, T	1
Ito, C	1
Odajima, K	1
Niimura, Y	1
Fujii, M	2
Sone, M	1
Asakawa, S	1
Arai, S	1
Yamazaki, O	1
Tamura, Y	1
Saito, K	1
Tada, Y	2
Yamamoto, T	3
Kozuma, K	1
Shibata, S	1
Fujigaki, Y	1
Bauer, M	1
Baholli, L	1
Uflacker, L	1
Rolffs, S	1
Dahl, EK	1
Abed, OK	1
Kjeldsen, J	3
Donia, M	1
Svane, IM	1
Dige, A	1
Agnholt, JS	1
Bjerrum, JT	1
Seidelin, JB	2
Saifuddin, A	1
Kent, AJ	1
Mehta, SJ	1
Hicks, LC	1
Gonzalez, HA	1
Segal, JP	1
Brookes, MJ	1
Subramanian, S	1
Bhala, N	1
Conley, TE	1
Patel, KV	1
Lamb, CA	1
Walker, GJ	1
Kennedy, NA	1
Sebastian, S	2
Coates, E	1
Wickramasekera, N	1
Barr, A	1
Shackley, P	1
Lee, M	1
Hind, D	1
Probert, C	1
Totton, N	1
Blackwell, S	1
Bedford, H	1
Dames, N	1
Lobo, A	1
Kita, A	1
Hashimoto, Y	1
Sato, K	1
Itoi, Y	1
Kasuga, K	1
Tanaka, H	2
Hosaka, H	1
Kuribayashi, S	1
Uraoka, T	1
Gn, D	1
Patil, M	1
Shafiq, S	1
Toba, T	1
Ikegami, R	1
Nogami, A	1
Watanabe, N	1
Fujii, K	1
Ogawa, Y	1
Hojo, A	1
Fujimoto, A	1
Matsuda, T	1
Fukura, S	1
Takei, M	1
Takeuchi, S	1
Tayama, T	1
Ono, A	1
Ichihara, Y	1
Shichijo, K	1
Suzuki, Y	2
Mori, K	1
Kondo, S	2
Oki, Y	1
Nagano, S	1
Ishikawa, Y	1
Yamada, T	1
Ichimori, T	2
Uchida, K	8
Sonoyama, H	1
Mishima, Y	1
Ishihara, S	2
Oshima, N	1
Moriyama, I	1
Kawashima, K	2
Chinuki, Y	1
Morita, E	1
Kinoshita, Y	2
Kearney, N	1
Harnett, C	1
Keohane, J	1
Thorne, J	1
Feighery, C	1
Collins, S	1
Zhou, H	1
Ikeuchi-Takahashi, Y	2
Hattori, Y	2
Onishi, H	2
Yoshida, A	1
Katsumata, Y	1
Hirahara, S	1
Hanaoka, M	1
Ochiai, M	1
Kobayashi, M	1
Harigai, M	1
Hayashida, S	1
Sato, S	3
Shimada, Y	1
Tsuzura, H	1
Ikeda, Y	1
Takahashi, S	2
Amano, N	1
Murata, A	1
Nagahara, A	1
Genda, T	1
Yasuda, T	1
Takagi, T	1
Hasegawa, D	1
Hirose, R	1
Inoue, K	1
Dohi, O	1
Yoshida, N	1
Kamada, K	1
Uchiyama, K	1
Ishikawa, T	1
Konishi, H	1
Naito, Y	1
Itoh, Y	1
Jansen, FM	1
Vavricka, SR	2
den Broeder, AA	1
de Jong, EM	1
Hoentjen, F	1
van Dop, WA	1
Dermawan, A	1
So, K	1
Venugopal, K	1
Picardo, S	1
Frese, JP	1
Gröne, J	1
Lauscher, JC	1
Konietschke, F	1
Kreis, ME	1
Seifarth, C	1
Nomura, O	1
Osada, T	1
Shibuya, T	1
Ishikawa, D	1
Haga, K	1
Kodani, T	1
Sakamoto, N	3
Ogihara, T	1
Yamaji, K	2
Watanabe, S	1
Iizuka, M	3
Etou, T	2
Kumagai, M	1
Matsuoka, A	1
Numata, Y	1
Sagara, S	2
Kojima, Y	1
Hirotsu, Y	1
Omata, W	1
Sugimori, M	1
Takaoka, S	1
Ashizawa, H	1
Nakagomi, K	1
Yoshimura, D	1
Hosoda, K	1
Mochizuki, H	2
Omata, M	2
Hamashige, J	1
Umemura, H	1
Asagoe, K	1
Teich, N	1
Stallmach, A	5
Patel, P	1
Yarur, A	1
Dalal, S	1
Sakuraba, A	1
Rubin, DT	1
Hanauer, SB	1
Hanan, I	1
Raffals, LH	1
Cohen, RD	1
Pekow, J	1
Marques da Costa, P	1
Correia, L	1
Correia, LA	1
Oka, T	1
Miyagaki, T	1
Isomura, S	1
Ichimura, Y	1
Kamata, M	1
Mitsui, H	1
Ishii, N	3
Hashimoto, T	2
Peter, J	1
Zeitz, J	1
Gherardi, A	1
Roze, S	1
Kuijvenhoven, J	1
Ghatnekar, O	1
Yip Sonderegger, YL	1
Imamura, R	1
Hayashi, K	1
Sada, KE	1
Yamamura, Y	1
Yamaguchi, S	1
Morishita, M	1
Watanabe, H	3
Matsumoto, Y	1
Wada, J	1
Konschake, W	1
Daeschlein, G	1
Jünger, M	1
Lutze, S	1
Arisaka, T	1
Kanazawa, M	1
Tominaga, K	2
Takahashi, F	1
Takenaka, K	1
Sugaya, T	1
Arisaka, O	1
Irisawa, A	1
Hiraishi, H	2
Tomoda, Y	1
Kagawa, S	1
Kurata, S	1
Tanaka, K	4
Kruis, W	2
Nguyen, P	1
Morgenstern, J	1
Ramlow, W	1
Dignaß, A	1
Drebber, U	1
Kikuchi, H	1
Sakuraba, H	1
Akemoto, Y	1
Murai, Y	1
Fukutoku, Y	1
Asari, T	1
Tatsuta, T	1
Hasui, K	1
Hiraga, H	1
Sawaya, M	1
Chinda, D	1
Mikami, T	1
Tanaka, M	2
Fukuda, S	1
Kawano, K	1
Tsukamoto, H	1
Tanida, S	1
Mizoshita, T	1
Ozeki, K	1
Ebi, M	1
Shimura, T	2
Mori, Y	1
Kataoka, H	1
Kamiya, T	1
Joh, T	1
Horikoshi, H	1
Takada, K	1
Higuchi, T	1
Yoshikawa, T	1
Matsumoto, M	2
Suzuki, K	1
Nakano, M	3
Hoshino, M	1
Kanke, K	1
Kniazev, OV	2
Lazebnik, LB	2
Parfenov, AI	2
Ruchkina, IN	2
Shcherbakov, PL	2
Konopliannikov, AG	2
Mikhaĭlova, ZF	2
Khomeriki, SG	2
Noble-Jamieson, G	1
Heuschkel, RB	1
Torrente, F	1
Hadzic, N	1
Zilbauer, M	1
Hideki, M	1
Tetsurou, T	1
Sakae, F	1
Kensei, K	1
Makoto, O	1
Toshinobu, K	1
Papiamonis, N	1
Koutroubakis, IE	1
Bossa, F	1
Annese, V	1
Valvano, MR	1
Latiano, A	1
Martino, G	1
Rossi, L	1
Magnani, M	1
Palmieri, O	1
Serafini, S	1
Damonte, G	1
De Santo, E	1
Andriulli, A	1
Pagoldh, M	1
Hultgren, E	1
Arnell, P	1
Eriksson, A	1
Tanaka, T	4
Sugiyama, S	1
Goishi, H	1
Kajihara, T	1
Akagi, M	1
Miura, T	1
Wong, SC	1
Catto-Smith, AG	1
Zacharin, M	1
Park, SK	1
Yang, SK	2
Ye, BD	1
Kim, KJ	1
Yang, DH	1
Jung, KW	1
Park, SH	2
Kim, JW	1
Byeon, JS	1
Myung, SJ	1
Kim, JH	1
Dhamija, P	1
Hota, D	1
Kochhar, R	1
Sachdev, A	1
Chakrabarti, A	1
Theede, K	1
Kiszka-Kanowitz, M	1
Nielsen, AM	1
Nordgaard-Lassen, I	1
Uchiyama, R	1
Arakura, F	1
Kiniwa, Y	1
Nakazawa, K	1
Uhara, H	1
Okuyama, R	1
Sidoroff, M	1
Kolho, KL	2
Gecse, KB	1
Lakatos, PL	2
Herculano, R	1
Barreiro, P	1
Hann, A	1
Chapim, I	1
Bispo, M	1
Santos, S	1
Monteiro, L	1
Chagas, C	1
Matos, L	1
Topal, F	1
Yonem, O	1
Tuzcu, N	1
Tuzcu, M	1
Ataseven, H	1
Akyol, M	1
Fujikawa, T	1
Takayama, K	1
Boules, E	1
Lyon, C	1
Araki, T	6
Kawamura, M	3
Okita, Y	6
Fujikawa, H	3
Toiyama, Y	1
Inoue, Y	2
Mohri, Y	3
Kusunoki, M	6
Kamiya, K	1
Aoyama, Y	1
Kawata, M	1
Takiguchi, T	1
Mitsui, S	1
Tokura, Y	1
Iwatsuki, K	1
Sagami, S	1
Ueno, Y	3
Tanaka, S	2
Nagai, K	1
Hayashi, R	1
Chayama, K	2
Kamiyama, T	1
Sasaki, S	1
Kobayashi, K	4
Fukuda, K	2
Miyake, Y	1
Aruga, T	1
Sueki, H	1
Wang, Y	1
MacDonald, JK	1
Benchimol, EI	2
Griffiths, AM	2
Steinhart, AH	2
Panaccione, R	1
Seow, CH	2
Torii, Y	1
Katano, Y	1
Yoshino, J	1
Inui, K	1
Wakabayasi, T	1
Kobayashi, T	1
Kosaka, T	3
Ashizuka, S	1
Inatsu, H	3
Kita, T	1
Kitamura, K	1
Ogawa, R	1
Oikawa, T	1
Shijo, T	1
Kanno, S	1
Shibuya, S	1
Nishimura, S	2
Yoshino, T	1
Fujikawa, Y	1
Watanabe, M	8
Yazumi, S	1
Ohno, M	1
Koyama, S	2
Ohara, M	2
Shimamoto, K	1
Kobayashi, Y	1
Nakamura, F	1
Mitsuru, K	1
Andoh, A	1
Orii, F	1
Maemoto, A	1
Ashida, T	3
Iida, T	5
Satoh, S	1
Nakagaki, S	2
Shimizu, H	1
Kaneto, H	1
Hu, J	1
Li, YK	1
Choi, M	1
Lynch, RW	1
Soane, T	1
Gibson, R	1
Pal, S	1
Lees, CW	1
Dey, YN	1
Sharma, G	1
Wanjari, MM	1
Kumar, D	1
Lomash, V	1
Jadhav, AD	1
Aktaş Karabay, E	1
Aksu Cerman, A	1
Kıvanc Altunay, İ	1
Yalçın, Ö	1
Kuznietsova, HM	1
Yena, MS	1
Kotlyar, IP	1
Ogloblya, OV	1
Rybalchenko, VK	1
Yamamoto, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
PHASE 2 STUDY OF DEXAMETHASONE 21-PHOSPHATE LOADED INTO AUTOLOGOUS ERYTHROCYTES IN STEROID-DEPENDENT ULCERATIVE COLITIS PATIENTS[NCT01171807]	Phase 2	40 participants (Anticipated)	Interventional	2003-04-30	Recruiting
Bone Density in Children With IBD Treated With Amorphous Calcium or Commercial Crystalline Calcium: A Prospective Randomized Multicenter Trial[NCT02470663]		0 participants (Actual)	Interventional	2015-07-31	Withdrawn (stopped due to company and Sheba did not reach an agreement)
Exploratory, Open-label Study to Demonstrate Efficacy, Safety and Tolerability of SC12267 (35 mg) in Patients With Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)[NCT00820365]	Phase 2	34 participants (Actual)	Interventional	2009-03-31	Completed
Efficacy of High-dose Corticosteroid Pulses Added to Conventional Oral Corticosteroid Course for Moderate Flares of Ulcerative Colitis.[NCT02921555]	Phase 4	75 participants (Actual)	Interventional	2018-10-11	Completed
A Randomized, Multicenter Open Label Study Comparing Cyclosporine With Infliximab in Steroid-refractory Severe Attacks of Ulcerative Colitis[NCT00542152]	Phase 4	115 participants (Actual)	Interventional	2007-06-30	Completed
An Investigator Initiated Study of Monocyte Biomarkers in Moderate to Severe Plaque Psoriasis Subjects Treated With Apremilast[NCT03442088]	Phase 2	28 participants (Actual)	Interventional	2018-06-01	Completed
An Investigator Initiated Open Study to Evaluate the Efficacy and Safety of Intra Arterial Infusion for Treatment of Steroid Resistant Acute Hepatic Graft Versus Host Disease (AGVHD)[NCT01140984]		2 participants (Actual)	Interventional	2010-09-30	Terminated (stopped due to technical issues)
Electronic Linkage for Inflammatory Bowel Disease to Deliver Joint Access to Health Reports[NCT02985476]		61 participants (Actual)	Interventional	2010-05-31	Completed
Dexamethasone Versus Methylprednisolone for the Treatment of Active Inflammatory Bowel Disease[NCT00152620]		40 participants	Interventional	2004-06-30	Terminated (stopped due to study completed)
Supplementation of Extra Virgin Olive Oil Monocultivar Coratina in Patients With Active Ulcerative Colitis[NCT03408847]		30 participants (Anticipated)	Interventional	2017-11-20	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To assess change in IL-17 in the identified patient AM-endotype computing relative percent reduction for each subject being treated and serum marker. The median and other summary statistics of these percent change values will be computed (NCT03442088)
Timeframe: Baseline, Week 16

Change in Serum Myeloperoxidase

Intervention	Pg/mL (Mean)
	Baseline	Week 16
Apremilast for Treatment of Psoriasis With the AM-endotype	1.513	-0.8315

To assess change in serum myeloperoxidase in the identified patient AM-endotype computing relative percent reduction for each subject being treated and serum marker. The median and other summary statistics of these percent change values will be computed (NCT03442088)
Timeframe: Baseline, Week 16

Change in Tissue Factor

Intervention	Pg/mL (Mean)
	Baseline	Week 16
Apremilast for Treatment of Psoriasis With the AM-endotype	24198	24294

To assess change in Tissue Factor in the identified patient AM-endotype computing relative percent reduction for each subject being treated and serum marker. The median and other summary statistics of these percent change values will be computed (NCT03442088)
Timeframe: Baseline, Week 16

Change in TNF Alpha

Intervention	Pg/mL (Mean)
	Baseline	Week 16
Apremilast for Treatment of Psoriasis With the AM-endotype	72.28	75.52

To assess change in in the identified patient AM-endotype computing relative percent reduction for each subject being treated and serum marker. The median and other summary statistics of these percent change values will be computed (NCT03442088)
Timeframe: Baseline, Week 16

The Primary Outcome Measure Will be to Evaluate Change in Aberrant Inflammatory Profiles of Activated Blood Monocytes (Aberrant-monocyte Endotype Patients (AM-endotype).

Intervention	Pg/mL (Mean)
	Baseline	Week 16
Apremilast for Treatment of Psoriasis With the AM-endotype	14.95	14.26

For each subject, we will identify a target biomarker of abnormally elevated monocytes, among 1.) intermediate, or 2.) doublets, or 3.) platelet doubles. Each subject will thus have one identified monocyte biomarker for which relative percent change will be its basis for analysis in the primary outcome measure. We will specifically assess change from baseline to 16 weeks by computing relative percent reduction for each subject being treated. Note for example that a change of 1.5% to 1.2% is (1 - (1.2/1.5))*100% = 20% reduction. The median and other summary statistics of these percent change values will be computed. Wilcoxon's signed rank test will be used to evaluate the null hypothesis of the median percent change being 0. (NCT03442088)
Timeframe: Baseline, Week 16

Article	Year
Clinical management of the most common extra-intestinal manifestations in patients with inflammatory bowel disease focused on the joints, skin and eyes. United European gastroenterology journal, 2020, Volume: 8, Issue:9 Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia;	2020
Pathological fractures in paediatric patients with inflammatory bowel disease. European journal of pediatrics, 2014, Volume: 173, Issue:2 Topics: Adolescent; Body Height; Body Weight; Bone Density; Child; Colitis, Ulcerative; Crohn Disease; Dipho	2014
Ulcerative proctitis: an update on the pharmacotherapy and management. Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:11 Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Disease Management; Humans; Mesalamine; Prednisolone;	2014
Drug-induced colonic Kaposi's sarcoma in a HIV-negative patient with ulcerative colitis: a case report and review of the literature. International journal of colorectal disease, 2014, Volume: 29, Issue:11 Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Colonic Neoplasms; HIV Seronegativity; Humans; Immunoc	2014
Type I interferons for induction of remission in ulcerative colitis. The Cochrane database of systematic reviews, 2015, Sep-14, Issue:9 Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Enema; Humans; Induction Chemotherapy; Interferon Typ	2015
[Second Korean Guideline for the Management of Ulcerative Colitis]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2017, Jan-25, Volume: 69, Issue:1 Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; C-Reactive Pr	2017
Type I interferons for induction of remission in ulcerative colitis. The Cochrane database of systematic reviews, 2008, Jul-16, Issue:3 Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Humans; Interferon Type I; Interferon-alpha; Interfer	2008
[Contemporary views on non-specific ulcerative colitis and conservative methods of its treatment ]. Voenno-meditsinskii zhurnal, 2008, Volume: 329, Issue:11 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Budesonide; Colitis, Ulcerative; Ga	2008
A case of tracheobronchitis in ulcerative colitis: a review of literature. The clinical respiratory journal, 2009, Volume: 3, Issue:1 Topics: Azathioprine; Biopsy, Needle; Bronchitis; Bronchoscopy; Colitis, Ulcerative; Drug Therapy, Combinati	2009
Therapy of steroid-resistant inflammatory bowel disease. Digestion, 2012, Volume: 86 Suppl 1 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Diseas	2012
[Inflammatory bowel diseases (IBD) -- critical discussion of etiology, pathogenesis, diagnostics, and therapy]. Der Radiologe, 2003, Volume: 43, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Bude	2003
[Conservative therapy of inflammatory bowel diseases]. Orvosi hetilap, 2002, Dec-15, Volume: 143, Issue:50 Topics: Acute Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Chro	2002
Steroid-induced osteonecrosis in refractory ulcerative colitis. Fukuoka igaku zasshi = Hukuoka acta medica, 2005, Volume: 96, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Female; Humans; Magnetic Resonance Imaging; Os	2005
[Surgical treatment for ulcerative colitis--recent advances]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63, Issue:5 Topics: Colitis, Ulcerative; Colonic Neoplasms; Digestive System Surgical Procedures; Humans; Prednisolone;	2005
[Guidelines for treatment of ulcerative colitis in children]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63, Issue:5 Topics: Azathioprine; Child; Colitis, Ulcerative; Contraindications; Cyclosporins; Growth Disorders; Humans;	2005
Pyodermatitis-pyostomatitis vegetans of the eyelids case report and review of the literature. Ophthalmology, 2005, Volume: 112, Issue:10 Topics: Adult; Colitis, Ulcerative; Colonoscopy; Eyelid Diseases; Folliculitis; Glucocorticoids; Humans; Mal	2005
Tumour necrosis factor alpha blocking agents for induction of remission in ulcerative colitis. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Colitis, Ulcerative; Humans; Infliximab; Prednisol	2006
[A case of sacroiliitis complicated by ulcerative colitis that was successfully treated with steroid]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2006, Volume: 103, Issue:8 Topics: Adult; Arthritis; Colitis, Ulcerative; Female; Humans; Prednisolone; Sacroiliac Joint	2006
[Treatment of inflammatory bowel disease]. Praxis, 2007, Feb-28, Volume: 96, Issue:9 Topics: Anti-Inflammatory Agents; Biological Products; Colitis, Ulcerative; Crohn Disease; Humans; Mesalamin	2007
[Study on the colon specific delivery of prednisolone using chitosan capsules]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2007, Volume: 127, Issue:4 Topics: Administration, Oral; Animals; Anti-Infective Agents; Capsules; Chitosan; Colitis, Ulcerative; Colon	2007
[Acute myelitis in a patient with ulcerative colitis]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Aug-10, Volume: 96, Issue:8 Topics: Acute Disease; Administration, Oral; Colitis, Ulcerative; Female; Humans; Magnetic Resonance Imaging	2007
[Ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8 Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Colitis, Ulcerative; Drugs, Chinese Herbal; Humans;	2007
Medical treatment of ulcerative colitis. Postgraduate medical journal, 1984, Volume: 60, Issue:709 Topics: Administration, Oral; Administration, Topical; Adrenocorticotropic Hormone; Aminosalicylic Acids; Az	1984
Toward optimal use of corticosteroids in ulcerative colitis and Crohn's disease. Gut, 1983, Volume: 24, Issue:3 Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Human	1983
[Ulcerative colitis associated with pyoderma gangrenosum]. Orvosi hetilap, 1994, Apr-24, Volume: 135, Issue:17 Topics: Adult; Chronic Disease; Colitis, Ulcerative; Foot Dermatoses; Humans; Male; Prednisolone; Pyoderma G	1994
Polymyositis associated with ulcerative colitis. Gut, 1993, Volume: 34, Issue:4 Topics: Aged; Aspirin; Chronic Disease; Colitis, Ulcerative; Colon; Drug Therapy, Combination; Female; Human	1993
[Advances in the topical steroid treatment of inflammatory bowel diseases]. Revista espanola de enfermedades digestivas, 1995, Volume: 87, Issue:11 Topics: Administration, Topical; Androstadienes; Anti-Inflammatory Agents; Beclomethasone; Budesonide; Clini	1995
[Ulcerative colitis and Crohn disease]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1996, Mar-10, Volume: 85, Issue:3 Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Humans; Immunoglobulin G; Immunosuppre	1996
[Specific respiratory manifestations associated with hemorrhagic rectocolitis. Analysis of a case and review of the literature]. Gastroenterologie clinique et biologique, 1996, Volume: 20, Issue:4 Topics: Bronchitis; Chronic Disease; Colectomy; Colitis, Ulcerative; Combined Modality Therapy; Female; Gluc	1996
[Ulcerative colitis and intestinal bleeding]. Nihon rinsho. Japanese journal of clinical medicine, 1998, Volume: 56, Issue:9 Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, U	1998
[Medical therapy in ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Colitis, Ulcerative; D	1999
[Leukocytapheresis for ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11 Topics: Adolescent; Anti-Inflammatory Agents; Colitis, Ulcerative; Humans; Leukapheresis; Male; Prednisolone	1999
[Treatment of mild and moderate ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Colitis, Ulcerativ	1999
[Therapeutic strategy for severe and fulminating ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11 Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Colectomy; Colitis, Ulcerative; Cyclosporine;	1999
[Ocular complications in ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11 Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Conjunctivitis; Diagnosis, Differential; Humans; Pred	1999
[Ulcerative colitis and pregnancy]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female; Fertility; Humans; Immu	1999
[Budesonide and inflammatory bowel disease]. Gastroenterologia y hepatologia, 1999, Volume: 22, Issue:10 Topics: Anti-Inflammatory Agents; Budesonide; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease;	1999
Basedow's disease and chronic ulcerative colitis: a case report and review of the Japanese literature. Internal medicine (Tokyo, Japan), 2001, Volume: 40, Issue:1 Topics: Adult; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antithyroid Agent	2001
[Severity and parenteral enteral nutrition for ulcerative colitis]. Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 5 Topics: Colitis, Ulcerative; Enteral Nutrition; Humans; Parenteral Nutrition; Perioperative Care; Prednisolo	2001
New steroids and new salicylates in inflammatory bowel disease: a critical appraisal. Gut, 2002, Volume: 50 Suppl 3 Topics: Acute Disease; Aspirin; Beclomethasone; Budesonide; Colitis, Ulcerative; Crohn Disease; Drug Therapy	2002
The management of ulcerative colitis. The Practitioner, 1976, Volume: 216, Issue:1296 Topics: Azathioprine; Colitis, Ulcerative; Cromolyn Sodium; Humans; Hydrocortisone; Prednisolone; Recurrence	1976
[Corticosteroids in gastroenterology]. Nederlands tijdschrift voor geneeskunde, 1978, Mar-25, Volume: 122, Issue:12 Topics: Adrenal Cortex Hormones; Burns, Chemical; Celiac Disease; Chronic Disease; Colitis, Ulcerative; Croh	1978
Inflammatory bowel disease presenting in pregnancy. The Australian & New Zealand journal of obstetrics & gynaecology, 1992, Volume: 32, Issue:1 Topics: Adult; Colitis, Ulcerative; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Prednisolone;	1992
[A case of ulcerative colitis with HLA haplotypes in a siblings]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1991, Jun-10, Volume: 80, Issue:6 Topics: Adult; Colitis, Ulcerative; Drug Combinations; Female; Glucosamine; Haplotypes; HLA Antigens; Humans	1991
[Parenteral and enteral nutrition for conservative treatment of inflammatory bowel disease]. Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49 Suppl Topics: Behcet Syndrome; Colitis, Ulcerative; Crohn Disease; Enteral Nutrition; Humans; Parenteral Nutrition	1991
The role of ciclosporin therapy in Crohn's disease. A review. Digestive diseases (Basel, Switzerland), 1991, Volume: 9, Issue:4 Topics: Colitis, Ulcerative; Crohn Disease; Cyclosporine; Drug Therapy, Combination; Enema; Humans; Predniso	1991
[The course and prognosis of ulcerative colitis]. Medizinische Klinik (Munich, Germany : 1983), 1989, Apr-15, Volume: 84, Issue:4 Topics: Colitis, Ulcerative; Combined Modality Therapy; Humans; Prednisolone; Sulfasalazine	1989
Chronic inflammatory bowel disease. Clinics in gastroenterology, 1986, Volume: 15, Issue:1 Topics: Child; Colectomy; Colitis, Ulcerative; Crohn Disease; Enema; Food, Formulated; Humans; Prednisolone;	1986
Does food affect acute inflammatory bowel disease? The role of parenteral nutrition, elemental and exclusion diets. Gut, 1986, Volume: 27, Issue:5 Topics: Acute Disease; Colitis, Ulcerative; Crohn Disease; Food, Formulated; Humans; Parenteral Nutrition; P	1986
Ulcerative colitis. Medical management. British medical journal, 1971, Mar-20, Volume: 1, Issue:5750 Topics: Adrenocorticotropic Hormone; Allergens; Animals; Arthritis; Blood Transfusion; Colitis, Ulcerative;	1971
Immunosuppressive therapy. 1. The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5 Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid	1972
Advances in gastroenterology. The Practitioner, 1972, Volume: 209, Issue:252 Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Colitis, Ulcerative; Diet; Disaccharides; Du	1972
Sclerosing cholangitis. Clinics in gastroenterology, 1973, Volume: 2, Issue:1 Topics: Age Factors; Anti-Bacterial Agents; Antifungal Agents; Bacterial Infections; Bile Duct Neoplasms; Bl	1973

Article	Year
Novel Leucocyte/Thrombocyte Apheresis for Induction of Steroid-Free Remission in Ulcerative Colitis: A Controlled Randomized Pilot Study. Journal of Crohn's & colitis, 2019, Jul-25, Volume: 13, Issue:7 Topics: Adult; Blood Platelets; Colitis, Ulcerative; Female; Germany; Glucocorticoids; Humans; Leukapheresis	2019
Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. Inflammatory bowel diseases, 2013, Volume: 19, Issue:9 Topics: Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Case-Control Studies; Colitis, Ulc	2013
Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study. Scandinavian journal of gastroenterology, 2013, Volume: 48, Issue:9 Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Colectomy;	2013
Randomized clinical trial: atorvastatin versus placebo in patients with acute exacerbation of mild to moderate ulcerative colitis. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2014, Volume: 33, Issue:2 Topics: Acute Disease; Adult; Atorvastatin; Colitis, Ulcerative; Disease Progression; Double-Blind Method; D	2014
Neutrophil-related immunoinflammatory disturbance in steroid-overdosed ulcerative colitis patients. Journal of gastroenterology, 2008, Volume: 43, Issue:10 Topics: Adult; Apoptosis; Cohort Studies; Colitis, Ulcerative; Cytokines; Dose-Response Relationship, Drug;	2008
Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide. Inflammatory bowel diseases, 2010, Volume: 16, Issue:8 Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Diseases; Colitis, Ulcerative; Drug Monitoring; Er	2010
Plasma histamine levels (H) during adjunctive H1-receptor antagonist treatment with loratadine in patients with active inflammatory bowel disease (IBD). Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59 Suppl 2 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Diseas	2010
Impact of defunctioning loop ileostomy on outcome after restorative proctocolectomy for ulcerative colitis. International journal of colorectal disease, 2011, Volume: 26, Issue:5 Topics: Adolescent; Adult; Aged; Colitis, Ulcerative; Female; Humans; Ileostomy; Male; Middle Aged; Postoper	2011
[Allogeneic mesenchymal stromal cells in patients with ulcerative colitis: two years of observation]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2010, Issue:11 Topics: Adult; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Colitis, Ulcerative;	2010
Leukocytapheresis in pediatric patients with ulcerative colitis. Journal of pediatric gastroenterology and nutrition, 2011, Volume: 53, Issue:1 Topics: Abdominal Pain; Adolescent; Body Weight; Child; Colitis, Ulcerative; Diarrhea; Dose-Response Relatio	2011
Capsule-endoscopic findings of ulcerative colitis patients. Digestion, 2011, Volume: 84, Issue:4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Case-Control Studies; Colitis, Ul	2011
Optimal apheresis treatment volume for the efficacy and safety of leukocytapheresis with Cellsorba in patients with active ulcerative colitis. Journal of clinical apheresis, 2011, Volume: 26, Issue:6 Topics: Adolescent; Adult; Aged; Blood Volume; Child; Colitis, Ulcerative; Female; Humans; Leukapheresis; Ma	2011
Topical treatment with the Toll-like receptor agonist DIMS0150 has potential for lasting relief of symptoms in patients with chronic active ulcerative colitis by restoring glucocorticoid sensitivity. Inflammatory bowel diseases, 2013, Volume: 19, Issue:2 Topics: Administration, Topical; Adult; Aged; Biomarkers; Colitis, Ulcerative; Colon; Colonoscopy; DNA; Drug	2013
Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: the ENTRANCE study. Journal of Crohn's & colitis, 2013, Volume: 7, Issue:8 Topics: Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Biphenyl Compounds; Blood Sedimentation; C-Reac	2013
Multicenter randomized controlled trial for the treatment of ulcerative colitis with a leukocytapheresis column. Current pharmaceutical design, 2003, Volume: 9, Issue:4 Topics: Adult; Chi-Square Distribution; Colitis, Ulcerative; Female; Humans; Leukapheresis; Male; Middle Age	2003
Oral prednisolone metasulphobenzoate in the treatment of active ulcerative colitis. Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:5 Topics: Administration, Oral; Anti-Inflammatory Agents; Colitis, Ulcerative; Female; Humans; Male; Middle Ag	2003
Combination immunomodulatory therapy with cyclosporine and azathioprine in corticosteroid-resistant severe ulcerative colitis: the Edinburgh experience of outcome. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35, Issue:8 Topics: Administration, Oral; Adult; Anti-Infective Agents; Azathioprine; Colitis, Ulcerative; Cyclosporine;	2003
Different therapy for different types of ulcerative colitis in China. World journal of gastroenterology, 2004, May-15, Volume: 10, Issue:10 Topics: Adult; Aminosalicylic Acids; Anti-Inflammatory Agents; Antigens, CD; ATP Binding Cassette Transporte	2004
Adsorptive granulocyte and monocyte apheresis versus prednisolone in patients with corticosteroid-dependent moderately severe ulcerative colitis. Digestion, 2004, Volume: 70, Issue:1 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Blood Component Removal; Colit	2004
Infliximab for acute, not steroid-refractory ulcerative colitis: a randomized pilot study. European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:11 Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Colitis, Ulcerative; F	2004
Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis. Gut, 2006, Volume: 55, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative;	2006
Leukocytapheresis therapy for steroid-naïve patients with active ulcerative colitis: its clinical efficacy and adverse effects compared with those of conventional steroid therapy. Journal of gastroenterology and hepatology, 2005, Volume: 20, Issue:10 Topics: Adolescent; Adult; Anti-Inflammatory Agents; Biological Therapy; Child; Colitis, Ulcerative; Female;	2005
A randomized trial of nicotine enemas for active ulcerative colitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Colitis, Ulcerative; Double-Blind Method; Enema; Female; Humans; Mal	2005
Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease. Alimentary pharmacology & therapeutics, 2006, May-15, Volume: 23, Issue:10 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Basiliximab; Colectomy; C	2006
Low-molecular-weight heparin (enoxaparin) as adjuvant therapy in the treatment of active ulcerative colitis: a randomized, controlled, comparative study. Alimentary pharmacology & therapeutics, 2006, May-15, Volume: 23, Issue:10 Topics: Adjuvants, Pharmaceutic; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Ami	2006
The proinflammatory CXC-chemokines GRO-alpha/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids. International journal of colorectal disease, 2007, Volume: 22, Issue:12 Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents; Biomarkers;	2007
Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitis. Alimentary pharmacology & therapeutics, 2008, Feb-01, Volume: 27, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents; Chi-Square Distribution; Colitis, Ulcerative; Double-Blind Me	2008
Intensive granulocyte and monocyte adsorption versus intravenous prednisolone in patients with severe ulcerative colitis: an unblinded randomised multi-centre controlled study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2008, Volume: 40, Issue:6 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Colitis, Ulcerative; Female; Granulocytes; Humans	2008
The effect of the acetylator phenotype on the metabolism of sulphasalazine in man. Journal of medical genetics, 1983, Volume: 20, Issue:1 Topics: Acetylation; Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Humans; Mesalamine	1983
Assessment of disease activity in inflammatory bowel disease: a new approach using 111In granulocyte scanning. British medical journal (Clinical research ed.), 1983, Dec-10, Volume: 287, Issue:6407 Topics: Colitis, Ulcerative; Crohn Disease; Female; Granulocytes; Humans; Indium; Male; Prednisolone; Radioi	1983
A comparison of prednisolone enemas with low-dose oral prednisolone in the treatment of acute distal ulcerative colitis. Diseases of the colon and rectum, 1984, Volume: 27, Issue:11 Topics: Acute Disease; Administration, Oral; Adult; Aged; Colitis, Ulcerative; Enema; Female; Humans; Male;	1984
Controlled trial of azathioprine in chronic ulcerative colitis. British medical journal (Clinical research ed.), 1982, May-01, Volume: 284, Issue:6325 Topics: Azathioprine; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Female; Humans; Ma	1982
A controlled trial of alternate day prednisolone as a maintenance treatment for ulcerative colitis in remission. Digestion, 1981, Volume: 22, Issue:5 Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Metho	1981
Budesonide versus prednisolone retention enemas in active distal ulcerative colitis. Alimentary pharmacology & therapeutics, 1994, Volume: 8, Issue:6 Topics: Adult; Anti-Inflammatory Agents; Budesonide; Colitis, Ulcerative; Endoscopy; Enema; Female; Humans;	1994
Safety of urgent restorative proctocolectomy with ileal pouch-anal anastomosis for fulminant colitis. Diseases of the colon and rectum, 1995, Volume: 38, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Algorithms; Anti-Bacterial Agents; Child; Child, Preschool;	1995
Mycobacterium paratuberculosis in intestinal tissue from patients with Crohn's disease demonstrated by a nested primer polymerase chain reaction. Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Base Sequence; Colitis, Ulcerative; Colon; Colonic Disea	1994
Double blind trial of oral fluticasone propionate v prednisolone in the treatment of active ulcerative colitis. Gut, 1993, Volume: 34, Issue:1 Topics: Adolescent; Adult; Aged; Androstadienes; Anti-Inflammatory Agents; Colitis, Ulcerative; Double-Blind	1993
Corticosteroids for the management of ulcerative colitis. Journal of gastroenterology, 1995, Volume: 30 Suppl 8 Topics: Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Female; Humans; Hydrocortisone; Male; Methylpr	1995
A randomised trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis. Gut, 1996, Volume: 38, Issue:2 Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Aged; Aged, 80 and over; Aminosalicylic Ac	1996
Transdermal nicotine compared with oral prednisolone therapy for active ulcerative colitis. European journal of gastroenterology & hepatology, 1996, Volume: 8, Issue:8 Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Colitis, Ulcerative; C	1996
Oral budesonide versus prednisolone in patients with active extensive and left-sided ulcerative colitis. Gastroenterology, 1996, Volume: 110, Issue:6 Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Bu	1996
A prospective randomized controlled trial of oral ciprofloxacin in acute ulcerative colitis. The American journal of gastroenterology, 1997, Volume: 92, Issue:3 Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aminosalicylic Acids; Anti-Infective A	1997
Beclomethasone dipropionate enemas versus prednisolone sodium phosphate enemas in the treatment of distal ulcerative colitis. Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:4 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Beclomethasone; Colitis, Ulcerative; Doubl	1998
Lack of clinical efficacy of additional factor XIII treatment in patients with steroid refractory colitis. The Factor XIII Study Group. Zeitschrift fur Gastroenterologie, 1999, Volume: 37, Issue:10 Topics: Adolescent; Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Double-Blind Method; Factor XIII;	1999
[Mechanism of leukocytapheresis effect in the treatment of ulcerative colitis]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 1999, Volume: 22, Issue:6 Topics: Adult; Colitis, Ulcerative; Female; Humans; Leukapheresis; Prednisolone	1999
Mycophenolate mofetil versus azathioprine in patients with chronic active ulcerative colitis: a 12-month pilot study. The American journal of gastroenterology, 2000, Volume: 95, Issue:5 Topics: Adult; Aged; Azathioprine; Chronic Disease; Colitis, Ulcerative; Drug Therapy, Combination; Female;	2000
[Chronic inflammatory bowel diseases. Do antihistaminics reduce the need for steroids?]. MMW Fortschritte der Medizin, 2000, Jun-01, Volume: 142, Issue:22 Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Histamine H	2000
An open-labeled, randomized study comparing systemic interferon-alpha-2A and prednisolone enemas in the treatment of left-sided ulcerative colitis. The American journal of gastroenterology, 2001, Volume: 96, Issue:6 Topics: Adult; Aged; Colitis, Ulcerative; Enema; Female; Glucocorticoids; Humans; Injections, Subcutaneous;	2001
Guided self-management and patient-directed follow-up of ulcerative colitis: a randomised trial. Lancet (London, England), 2001, Sep-22, Volume: 358, Issue:9286 Topics: Administration, Topical; Adolescent; Adult; Aged; Ambulatory Care; Anti-Inflammatory Agents; Anti-In	2001
Octreotide in patients with active ulcerative colitis treated with high dose corticosteroids (OPUS 1). European journal of gastroenterology & hepatology, 2002, Volume: 14, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Double-Blind Method; Drug Admin	2002
The effects of prednisolone in leucocyte function in man. A double blind controlled study. Clinical and experimental immunology, 1977, Volume: 28, Issue:2 Topics: Clinical Trials as Topic; Colitis, Ulcerative; Cytotoxicity Tests, Immunologic; Humans; Leukocyte Co	1977
Role of oxygen-derived free radical scavengers in the management of recurrent attacks of ulcerative colitis: a new approach. The Journal of laboratory and clinical medicine, 1992, Volume: 119, Issue:6 Topics: Adult; Allopurinol; Blood Sedimentation; Colitis, Ulcerative; Dimethyl Sulfoxide; Double-Blind Metho	1992
Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut, 1992, Volume: 33, Issue:7 Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Colitis, Ulcerative; Drug Therapy, Combination; Eicos	1992
Role of sulphydryl-containing agents in the management of recurrent attacks of ulcerative colitis. A new approach. Pharmacology, 1992, Volume: 45, Issue:6 Topics: Adult; Aged; Anti-Ulcer Agents; Colitis, Ulcerative; Cysteine; Double-Blind Method; Drug Administrat	1992
Double blind, controlled trial of 4-aminosalicylic acid and prednisolone enemas in distal ulcerative colitis. Gut, 1992, Volume: 33, Issue:7 Topics: Aminosalicylic Acid; Colitis, Ulcerative; Double-Blind Method; Drug Administration Schedule; Enema;	1992
Budesonide enema in distal ulcerative colitis. A randomized dose-response trial with prednisolone enema as positive control. The Danish Budesonide Study Group. Scandinavian journal of gastroenterology, 1991, Volume: 26, Issue:12 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Budesonide; Colitis, Ulcerative; Dose-Resp	1991
Morphometric studies in rectal biopsy specimens from patients with ulcerative colitis: effect of oral 5 amino salicylic acid and rectal prednisolone treatment. Gut, 1991, Volume: 32, Issue:2 Topics: Aminosalicylic Acids; Biopsy; Colitis, Ulcerative; Diagnosis, Computer-Assisted; Double-Blind Method	1991
A comparison of sucralfate and prednisolone enemas in the treatment of active distal ulcerative colitis. Scandinavian journal of gastroenterology, 1989, Volume: 24, Issue:8 Topics: Adult; Aged; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Enema; Female; Huma	1989
Comparison of beclomethasone dipropionate (2 and 3 mg) and prednisolone sodium phosphate enemas (30 mg) in the treatment of ulcerative proctitis. An adrenocortical approach. The Netherlands journal of medicine, 1989, Volume: 35, Issue:1-2 Topics: Adult; Aged; Beclomethasone; Colitis, Ulcerative; Enema; Female; Humans; Hydrocortisone; Male; Middl	1989
[Adjuvant therapy with elemental diet in chronic inflammatory intestinal diseases. Comparative study]. Deutsche medizinische Wochenschrift (1946), 1986, Feb-21, Volume: 111, Issue:8 Topics: Adolescent; Adult; Blood Proteins; Blood Sedimentation; Colitis, Ulcerative; Combined Modality Thera	1986
Topical 5-aminosalicylic acid versus prednisolone in ulcerative proctosigmoiditis. A randomized, double-blind multicenter trial. Danish 5-ASA Group. Digestive diseases and sciences, 1987, Volume: 32, Issue:6 Topics: Administration, Topical; Adolescent; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology, 1986, Volume: 91, Issue:4 Topics: Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Dialysis; Dinopros	1986
Comparison of 5-aminosalicylic acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of distal ulcerative colitis. A prospective, randomized, double-blind trial. Scandinavian journal of gastroenterology, 1988, Volume: 23, Issue:8 Topics: Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Metho	1988
A defence of the small clinical trial: evaluation of three gastroenterological studies. British medical journal (Clinical research ed.), 1986, Mar-01, Volume: 292, Issue:6520 Topics: Adult; Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Colonic Diseases, Functi	1986
Comparative trial of sodium cromoglycate enemas with prednisolone enemas in the treatment of ulcerative colitis. Gut, 1987, Volume: 28, Issue:1 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Colitis, Ulcerative; Cromolyn Sodium; Double-Blin	1987
A controlled randomized trial of budesonide versus prednisolone retention enemas in active distal ulcerative colitis. Scandinavian journal of gastroenterology, 1987, Volume: 22, Issue:8 Topics: Adolescent; Adult; Aged; Budesonide; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Met	1987
Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis. Gut, 1985, Volume: 26, Issue:8 Topics: Adult; Aged; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Enema; Female; Huma	1985
Effect of treatment on symptoms and quality of life in patients with ulcerative colitis: comparative trial of hydrocortisone acetate foam and prednisolone 21-phosphate enemas. British medical journal (Clinical research ed.), 1985, Sep-28, Volume: 291, Issue:6499 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Clinical Trials as Topic; Colitis, Ulcerat	1985
A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin). Gut, 1973, Volume: 14, Issue:12 Topics: Biopsy; Blood Cell Count; Blood Sedimentation; Clinical Trials as Topic; Colitis, Ulcerative; Headac	1973
[Basis of the immunosuppressive therapy of ulcerative colitis in childhood]. Monatsschrift fur Kinderheilkunde, 1972, Volume: 120, Issue:6 Topics: Adolescent; Adrenal Cortex Hormones; Azathioprine; Child; Clinical Trials as Topic; Colitis, Ulcerat	1972
Azathioprine in ulcerative colitis: final report on controlled therapeutic trial. British medical journal, 1974, Dec-14, Volume: 4, Issue:5945 Topics: Acute Disease; Adult; Azathioprine; Biopsy; Colitis, Ulcerative; Diarrhea; Erythema; Female; Humans;	1974
Immunosuppressive therapy. 1. The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5 Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid	1972
Betamethasone 17-valerate and prednisolone 21-phosphate retention enemata in proctocolitis. A multicentre trial. British medical journal, 1971, Jul-10, Volume: 3, Issue:5766 Topics: Adolescent; Adrenal Glands; Adult; Aged; Betamethasone; Colitis, Ulcerative; Depression, Chemical; E	1971

prednisolone and Colitis Gravis