Page last updated: 2024-11-06

prednisolone and Cardiovascular Diseases

prednisolone has been researched along with Cardiovascular Diseases in 36 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
"To examine the long-term effects of early low-dose prednisolone use in patients with rheumatoid arthritis (RA) on cardiovascular (CV) morbidity and mortality."9.19Low-dose prednisolone treatment of early rheumatoid arthritis and late cardiovascular outcome and survival: 10-year follow-up of a 2-year randomised trial. ( Ajeganova, S; Hafström, I; Svensson, B, 2014)
"To examine the long-term effects of early low-dose prednisolone use in patients with rheumatoid arthritis (RA) on cardiovascular (CV) morbidity and mortality."5.19Low-dose prednisolone treatment of early rheumatoid arthritis and late cardiovascular outcome and survival: 10-year follow-up of a 2-year randomised trial. ( Ajeganova, S; Hafström, I; Svensson, B, 2014)
" We sought to test the hypothesis that tapering of prednisolone (TAP) the first year after renal transplantation improves insulin sensitivity (IS), and to assess the effect of complete steroid withdrawal (SW) on IS in patients on a cyclosporine-based immunosuppressive regimen."5.11Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal. ( Egeland, T; Hartmann, A; Hjelmesaeth, J; Jenssen, T; Lund, K; Midtvedt, K; Paulsen, D, 2004)
" History of lupus nephritis and a higher average dose of prednisolone used since diagnosis were associated with cIMT progression in patients."3.96Similar progression of carotid intima-media thickness in 7-year surveillance of patients with mild SLE and controls, but this progression is still promoted by dyslipidaemia, lower HDL levels, hypertension, history of lupus nephritis and a higher prednisol ( Ajeganova, S; Frostegård, J; Gustafsson, T; Hafström, I; Lindberg, L, 2020)
"Our results indicate that obesity, distribution of obesity, and prednisolone treatment are the predominant determinants of insulin resistance long term after transplantation."3.74Determinants of insulin resistance in renal transplant recipients. ( Bakker, SJ; de Jong, PE; de Vries, AP; Gans, RO; Gansevoort, RT; Oterdoom, LH; Ploeg, RJ; van der Heide, JJ; van Son, WJ, 2007)
"Hypercholesterolemia was observed in 46% to 80% and hypertriglyceridemia in 43% to 78% of sirolimus-treated patients during the first 6 posttransplantation months."3.72Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: incidence, risk factors, progression, and prognosis. ( Chueh, SC; Kahan, BD, 2003)
"Treatment with leflunomide or low doses of glucocorticoids were not associated with severe course in our cohort."2.82COVID-19 among patients with giant cell arteritis: a single-centre observational study from Slovenia. ( Hočevar, A; Ješe, R; Kramarič, J; Rotar, Ž; Tomšič, M, 2022)
" Hence, a reduction in CsA dosage in kidney transplant recipients (KTR) may improve long-term outcomes."2.71Analysis of the cardiovascular risk profile in stable kidney transplant recipients after 50% cyclosporine reduction. ( Cardarelli, F; Cosimi, AB; Delmonico, FL; Farrell, ML; Pascual, M; Saidman, SL; Shih, V; Tolkoff-Rubin, N; Winkelmayer, WC; Wong, W, 2004)
"Cancer was less common in recipients with a higher BMI (hazard ratio (HR) 0."1.48Is big bad or bearable? Long-term renal transplant outcomes in obese recipients. ( Courtney, AE; Devine, PA; McCaughan, JA; McCloskey, OM, 2018)
"Hypercholesterolemia was evident in 66."1.30Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation. ( Bechstein, WO; Guckelberger, O; Jonas, S; Kratschmer, B; Lemmens, HP; Luesebrink, R; Neuhaus, PL; Neuhaus, R, 1997)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199010 (27.78)18.7374
1990's4 (11.11)18.2507
2000's10 (27.78)29.6817
2010's8 (22.22)24.3611
2020's4 (11.11)2.80

Authors

AuthorsStudies
Kramarič, J1
Ješe, R1
Tomšič, M1
Rotar, Ž1
Hočevar, A1
Ajeganova, S2
Gustafsson, T1
Lindberg, L1
Hafström, I2
Frostegård, J1
Vedder, D1
Nurmohamed, MT1
McCloskey, OM1
Devine, PA1
Courtney, AE1
McCaughan, JA1
Rahvar, AH1
Haas, CS1
Danneberg, S1
Harbeck, B1
van Dijk, M1
van Roon, AM1
Said, MY1
Bemelman, FJ1
Homan van der Heide, JJ1
de Fijter, HW1
de Vries, APJ1
Bakker, SJL1
Sanders, JSF1
Nielsen, CB1
Nielsen, C1
Nybo, M1
Just, SA1
Vinholt, PJ1
Svensson, B1
Barzenje, DA1
Cvancarova Småstuen, M1
Liestøl, K1
Fosså, A1
Delabie, J1
Kolstad, A1
Holte, H1
Verhoeven, F1
Totoson, P1
Maguin-Gaté, K1
Prigent-Tessier, A1
Marie, C1
Wendling, D1
Moretto, J1
Prati, C1
Demougeot, C1
Sugiyama, T1
Suzuki, S1
Yoshida, T1
Suyama, K1
Tanaka, T1
Sueishi, M1
Tatsuno, I1
Takagi, S1
Komatsu, N1
Martínez-Berriotxoa, A1
Ruiz-Irastorza, G1
Egurbide Arberas, MV1
Rueda Gutiérrez, M1
Aguirre Errasti, C1
Chueh, SC1
Kahan, BD1
BRIGDEN, W1
SIEGENTHALER, W1
SIEGENTHALER, G1
BONER, A1
DOUGLAS, AC1
Lyman, GH1
Morrison, VA1
Dale, DC1
Crawford, J1
Delgado, DJ1
Fridman, M1
Wong, W1
Tolkoff-Rubin, N1
Delmonico, FL1
Cardarelli, F1
Saidman, SL1
Farrell, ML1
Shih, V1
Winkelmayer, WC1
Cosimi, AB1
Pascual, M1
Midtvedt, K1
Hjelmesaeth, J1
Hartmann, A1
Lund, K1
Paulsen, D1
Egeland, T1
Jenssen, T1
Raza, K1
Banks, M1
Kitas, GD1
Oterdoom, LH1
de Vries, AP1
Gansevoort, RT1
van Son, WJ1
van der Heide, JJ1
Ploeg, RJ1
de Jong, PE1
Gans, RO1
Bakker, SJ1
Sonneveld, P1
de Ridder, M1
van der Lelie, H1
Nieuwenhuis, K1
Schouten, H1
Mulder, A1
van Reijswoud, I1
Hop, W1
Lowenberg, B1
Koike, M1
Ishiyama, T1
Guckelberger, O1
Bechstein, WO1
Neuhaus, R1
Luesebrink, R1
Lemmens, HP1
Kratschmer, B1
Jonas, S1
Neuhaus, PL1
Yoshida, C1
Miyachi, Y1
Hall, RL1
Leahy, MF1
Uddhammar, A1
Eriksson, AL1
Nyström, L1
Stenling, R1
Rantapää-Dahlqvist, S1
Moroni, G1
Banfi, G1
Ponticelli, C1
Morandini, G1
Spanedda, M1
Spanedda, L1
Egorova, LI1
Moiseev, VS2
Fiegel, G1
Gardell, C1
Tuchweber, B1
Hatakeyama, S1
Kovacs, K1
Argov, IuM1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Prednisone on Atherogenesis as Studied in the Macrophage Foam Cell Formation Model System.[NCT03367663]Early Phase 110 participants (Actual)Interventional2018-01-17Completed
TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study[NCT03272854]606 participants (Actual)Observational [Patient Registry]2001-08-31Active, not recruiting
ACtive Care After Transplantation, a Lifestyle Intervention in Renal Transplant Recipients[NCT01047410]221 participants (Actual)Interventional2010-10-31Completed
Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA, Versus Standard Dose Tacrolimus, ECMPA Plus Corticosteroids in Patients Undergoing Liver Transplant[NCT02123108]Phase 459 participants (Actual)Interventional2011-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Participants Experiencing Acute Rejection Episode

(NCT02123108)
Timeframe: 12 months post liver transplant

InterventionParticipants (Count of Participants)
Basiliximab3
Tacrolimus Group4

Participants Experiencing Adverse Event Attributable to Study Drug

(NCT02123108)
Timeframe: 12 months post liver transplantation

InterventionParticipants (Count of Participants)
Basiliximab0
Tacrolimus Group0

Participants Experiencing Graft Failure

(NCT02123108)
Timeframe: 12 months post transplant

InterventionParticipants (Count of Participants)
Basiliximab2
Tacrolimus Group5

Renal Recovery/ Function

Number of participants who experienced dialysis independence or improvement based upon kidney function labs as a measure of renal recovery/ function following OLT in patients after undergoing orthotopic liver transplant (NCT02123108)
Timeframe: 12 months post-transplant

InterventionParticipants (Count of Participants)
Basiliximab28
Tacrolimus Group26

Survival

Participants at risk minus incidence of death within the first year post-transplant (NCT02123108)
Timeframe: 12 months post liver transplant

InterventionParticipants (Count of Participants)
Basiliximab28
Tacrolimus Group26

Reviews

9 reviews available for prednisolone and Cardiovascular Diseases

ArticleYear
COVID-19 among patients with giant cell arteritis: a single-centre observational study from Slovenia.
    Clinical rheumatology, 2022, Volume: 41, Issue:8

    Topics: Cardiovascular Diseases; COVID-19; Giant Cell Arteritis; Glucocorticoids; Humans; Hypertension; Lefl

2022
Increased Cardiovascular Risk in Patients with Adrenal Insufficiency: A Short Review.
    BioMed research international, 2017, Volume: 2017

    Topics: Adrenal Insufficiency; Cardiovascular Diseases; Cardiovascular System; Glucocorticoids; Hormone Repl

2017
Risk-benefit assessment in management of adult idiopathic thrombocytopenic purpura.
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2011, Volume: 52, Issue:11

    Topics: Adrenal Cortex Hormones; Animals; Arteriosclerosis; Cardiovascular Diseases; Diabetes Mellitus; Huma

2011
[TREATMENT OF KIDNEY DISEASES, CARDIAC AND VASCULAR DISORDERS AS WELL AS COLLAGENOSES WITH CORTISONES].
    Die Therapiewoche, 1964, Volume: 14

    Topics: Adams-Stokes Syndrome; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis, Rheumatoid;

1964
[Hypereosinophilic syndrome].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:3

    Topics: Adult; Aged; Cardiovascular Diseases; Eosinophilia; Female; Humans; Hydroxyurea; Leukemia, Eosinophi

1993
[Lipid metabolism in Cushing's syndrome].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 3

    Topics: Cardiovascular Diseases; Cushing Syndrome; Humans; Hyperlipidemias; Insulin Resistance; Lipid Metabo

2001
[Use of cortisol and its derivatives in clinic practice].
    Terapevticheskii arkhiv, 1967, Volume: 39, Issue:6

    Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Arthritis, Rheumatoid;

1967
[Use of glucocorticoid hormones in the pathology of the cardiovascular system].
    Kardiologiia, 1972, Volume: 12, Issue:3

    Topics: Adrenal Glands; Animals; Cardiovascular Diseases; Cell Membrane; Cortisone; Diuresis; Electrocardiog

1972
[Pathologic changes in the cardiovascular system during treatment with glucocorticoid hormones].
    Kardiologiia, 1972, Volume: 12, Issue:10

    Topics: Animals; Arteriosclerosis; Arthritis, Rheumatoid; Asparagine; Biological Transport, Active; Calcium;

1972

Trials

5 trials available for prednisolone and Cardiovascular Diseases

ArticleYear
Long-term cardiovascular outcome of renal transplant recipients after early conversion to everolimus compared to calcineurin inhibition: results from the randomized controlled MECANO trial.
    Transplant international : official journal of the European Society for Organ Transplantation, 2018, Volume: 31, Issue:12

    Topics: Adult; Basiliximab; Calcineurin; Calcineurin Inhibitors; Cardiovascular Diseases; Carotid Intima-Med

2018
Low-dose prednisolone treatment of early rheumatoid arthritis and late cardiovascular outcome and survival: 10-year follow-up of a 2-year randomised trial.
    BMJ open, 2014, Apr-07, Volume: 4, Issue:4

    Topics: Age Factors; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Coronary Dise

2014
Analysis of the cardiovascular risk profile in stable kidney transplant recipients after 50% cyclosporine reduction.
    Clinical transplantation, 2004, Volume: 18, Issue:4

    Topics: Adult; Blood Pressure; C-Reactive Protein; Cardiovascular Diseases; Cyclosporine; Female; Graft Surv

2004
Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:12

    Topics: Body Weight; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Glucocorticoids; Graft Rejection; H

2004
Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkin's lymphoma using CHOP versus CNOP chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10

    Topics: Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined

1995

Other Studies

22 other studies available for prednisolone and Cardiovascular Diseases

ArticleYear
Similar progression of carotid intima-media thickness in 7-year surveillance of patients with mild SLE and controls, but this progression is still promoted by dyslipidaemia, lower HDL levels, hypertension, history of lupus nephritis and a higher prednisol
    Lupus science & medicine, 2020, Volume: 7, Issue:1

    Topics: Adult; Aged; Cardiovascular Diseases; Carotid Artery Diseases; Carotid Intima-Media Thickness; Case-

2020
[Increased cardiovascular risk due to glucocorticoids: how strong is the evidence?]
    Nederlands tijdschrift voor geneeskunde, 2021, 04-08, Volume: 165

    Topics: Adrenal Cortex Hormones; Arrhythmias, Cardiac; Cardiovascular Diseases; Dose-Response Relationship,

2021
Is big bad or bearable? Long-term renal transplant outcomes in obese recipients.
    QJM : monthly journal of the Association of Physicians, 2018, Jun-01, Volume: 111, Issue:6

    Topics: Adult; Body Mass Index; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus; Female; Graft Rejec

2018
The in vitro effect of antirheumatic drugs on platelet function.
    Platelets, 2020, Volume: 31, Issue:2

    Topics: Adalimumab; Adenosine Diphosphate; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Blood Pl

2020
Radiotherapy Compared to Other Strategies in the Treatment of Stage I/II Follicular Lymphoma: A Study of 404 Patients with a Median Follow-Up of 15 Years.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cardiova

2015
Glucocorticoids improve endothelial function in rheumatoid arthritis: a study in rats with adjuvant-induced arthritis.
    Clinical and experimental immunology, 2017, Volume: 188, Issue:2

    Topics: Acetylcholine; Animals; Aorta; Arginase; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid;

2017
Incidence of symptomatic vertebral fractures in women of childbearing age newly treated with high-dose glucocorticoid.
    Gender medicine, 2010, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Cardiovascular Diseases; Cohort Studies; Confi

2010
[Plasma homocysteine levels in systemic lupus erythematosus].
    Medicina clinica, 2003, May-17, Volume: 120, Issue:18

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Cardiovascular Diseases; Cholesterol; Creatinine;

2003
Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: incidence, risk factors, progression, and prognosis.
    Transplantation, 2003, Jul-27, Volume: 76, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; Cardiovascular Diseases; Cohort Studies; Cyclosporine; Disease Prog

2003
Cardiovascular disease: heart and major vessels; medical.
    The Medical annual, 1958, Volume: 76

    Topics: Cardiovascular Diseases; Heart; Humans; Prednisolone

1958
SARCOIDOSIS.
    Current medicine and drugs, 1964, Volume: 4, Issue:9

    Topics: Adrenal Cortex Hormones; Bone Diseases; Cardiovascular Diseases; Dermatology; Endocrinology; Eye Man

1964
Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy.
    Leukemia & lymphoma, 2003, Volume: 44, Issue:12

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Body Te

2003
Reversing myocardial microvascular disease in a patient with rheumatoid arthritis.
    The Journal of rheumatology, 2005, Volume: 32, Issue:4

    Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Coronary Angiography; Coronary Circulation; Cyclospo

2005
Determinants of insulin resistance in renal transplant recipients.
    Transplantation, 2007, Jan-15, Volume: 83, Issue:1

    Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up

2007
Determinants of insulin resistance in renal transplant recipients.
    Transplantation, 2007, Jan-15, Volume: 83, Issue:1

    Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up

2007
Determinants of insulin resistance in renal transplant recipients.
    Transplantation, 2007, Jan-15, Volume: 83, Issue:1

    Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up

2007
Determinants of insulin resistance in renal transplant recipients.
    Transplantation, 2007, Jan-15, Volume: 83, Issue:1

    Topics: Adult; Aged; Body Composition; Body Mass Index; Cardiovascular Diseases; Exercise; Female; Follow-Up

2007
Cardiovascular risk factors in long-term follow-up after orthotopic liver transplantation.
    Clinical transplantation, 1997, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Glucose; Cardiovascular Diseases; Cyclosporine; Female; Follow-Up Stu

1997
Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment.
    European journal of haematology, 2001, Volume: 66, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Azathiop

2001
Increased mortality due to cardiovascular disease in patients with giant cell arteritis in northern Sweden.
    The Journal of rheumatology, 2002, Volume: 29, Issue:4

    Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cause of Death; Comorbidity; Dose-Response Relatio

2002
Clinical status of patients after 10 years of lupus nephritis.
    The Quarterly journal of medicine, 1992, Volume: 84, Issue:305

    Topics: Adult; Brain Diseases; Cardiovascular Diseases; Female; Follow-Up Studies; Humans; Immunosuppressive

1992
[Further observations on the cortisonic and aldosterone potentiation of the action of angiotensin in man].
    Minerva medica, 1967, Apr-28, Volume: 58, Issue:34

    Topics: Adult; Aldosterone; Angiotensin II; Betamethasone; Blood Pressure; Cardiovascular Diseases; Drug Syn

1967
[Experimental results on the diabetogenic effect of fluprednisolone in the corticoid-glucose-tolerance-test].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:7

    Topics: Adult; Aged; Blood Glucose; Cardiovascular Diseases; Dexamethasone; Diabetes Mellitus; Fluprednisolo

1969
[Steroids and nephrectomy cardiopathy].
    Revue canadienne de biologie, 1970, Volume: 29, Issue:2

    Topics: Animals; Calcinosis; Cardiovascular Diseases; Desoxycorticosterone; Estradiol; Ethylestrenol; Heart

1970
[Electrocardiographic studies in patients with infectious hepatitis, cardio-vascular diseases and symptoms of heart and coronary insufficiency during treatment with corticosteroids (prednisolone)].
    Terapevticheskii arkhiv, 1968, Volume: 40, Issue:7

    Topics: Cardiovascular Diseases; Electrocardiography; Female; Heart; Hepatitis A; Humans; Middle Aged; Predn

1968