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prednisolone and Abortion, Recurrent

prednisolone has been researched along with Abortion, Recurrent in 38 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Research Excerpts

ExcerptRelevanceReference
"This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment."7.91The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study. ( Cooper, S; Laird, SM; Li, TC; Mariee, N; Metwally, M, 2019)
"Prednisolone or IVIG was then added to the tube with E:T ratio of 50:1 to assess suppressive effect."5.35Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity. ( Abdalla, HI; Bansal, A; Bhaskaran, S; Ford, B; Sumar, N; Thum, MY, 2008)
"We did a statistical analysis and found that oral immunosuppressants (including cyclosporine A or prednisolone) can improve pregnancy outcomes in patients with idiopathic RM, increase live birth rate and ongoing pregnancy rate, and reduce miscarriage rate."5.22Oral immunosuppressants improve pregnancy outcomes in women with idiopathic recurrent miscarriage: A meta-analysis. ( Hang, F; Liao, M; Ma, N; Qin, A; Qin, R; Qin, W; Zhao, Y, 2022)
"The effects of prednisolone on pregnancy outcome are open to debate."4.91Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis. ( Dan, S; Hong, L; Hongbo, C; Jiaxiong, W; Shenmin, Y; Wei, W; Yichao, S, 2015)
"This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment."3.91The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study. ( Cooper, S; Laird, SM; Li, TC; Mariee, N; Metwally, M, 2019)
"We treated four pregnancy cases positive for antiphospholipid antibodies (APLs) who had experienced recurrent second trimester fetal or neonatal losses using a Japanese modified Chinese herbal medicine, Sairei-to, low dose aspirin and adrenocorticosteroid hormone."3.72Effect of sairei-to combined with aspirin and prednisolone on four recurrent reproductive failure women who are positive for anti-phospholipid antibodies. ( Adachi, H; Ishii, K; Kurabayasi, T; Kurata, H; Natsume, N; Takaki, Y; Takakuwa, K; Tamura, M; Tanaka, K, 2003)
" The question of whether anti-GM3 antibodies might exert influence in APLs-positive recurrent pregnancy loss patients who are undergoing prednisolone and aspirin (PSL/ASA) treatment was investigated."3.69Clinical significance of anti-GM3 antibodies in recurrent pregnancy loss with elevated level of antiphospholipid antibodies. ( Aoki, K; Aoyama, T; Kunimatsu, M; Ozaki, Y, 1995)
"Idiopathic recurrent miscarriage is defined as 3 consecutive pregnancy losses with no contributing features found on investigations."2.74Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium. ( Alfirevic, Z; Drury, J; Quenby, S; Tang, AW; Turner, MA, 2009)
"Pregnancy was successfully carried out in 12/12 (100%) SLE-RSA patients with a mean Apgar score of 8."2.73Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion. ( Cipriani, P; De Carolis, C; Fontana, L; Giacomelli, R; Greco, E; Kröegler, B; Perricone, C; Perricone, R, 2008)
"Prednisolone treatment reduces endometrial vascular maturation and angiogenic growth factor expression in women with RM with increased uNK cells."1.37Prednisolone treatment reduces endometrial spiral artery development in women with recurrent miscarriage. ( Bulmer, JN; Drury, JA; Innes, BA; Lash, GE; Quenby, S; Robson, SC, 2011)
"Prednisolone or IVIG was then added to the tube with E:T ratio of 50:1 to assess suppressive effect."1.35Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity. ( Abdalla, HI; Bansal, A; Bhaskaran, S; Ford, B; Sumar, N; Thum, MY, 2008)
"Prednisolone treatment significantly reduced the number of CD56 cells in the endometrium, from a median of 14% (before) to 9% (after) (P=."1.33Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. ( Bates, M; Farquharson, R; Kalumbi, C; Quenby, S; Vince, G, 2005)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19907 (18.42)18.7374
1990's11 (28.95)18.2507
2000's8 (21.05)29.6817
2010's9 (23.68)24.3611
2020's3 (7.89)2.80

Authors

AuthorsStudies
Ma, N1
Qin, R1
Qin, W1
Liao, M1
Zhao, Y1
Hang, F1
Qin, A1
Nørgaard-Pedersen, C1
Nielsen, K1
Steffensen, R1
Eriksen, L1
Jørgensen, MM1
Kesmodel, US1
Christiansen, OB1
Woon, EV1
Day, A1
Bracewell-Milnes, T1
Male, V1
Johnson, M1
Sasaki, A1
Kuroda, K1
Hisano, M1
Ozawa, N2
Sago, H1
Yamaguchi, K1
Deguchi, M1
Maesawa, Y1
Kubota, S1
Morizane, M1
Tanimura, K1
Ebina, Y1
Yamada, H1
Cooper, S1
Laird, SM1
Mariee, N1
Li, TC1
Metwally, M1
Tang, AW2
Alfirevic, Z2
Turner, MA2
Drury, JA2
Small, R1
Quenby, S5
Gomaa, MF1
Elkholy, AG1
El-Said, MM1
Abdel-Salam, NE1
Lynch, E1
Dan, S1
Wei, W1
Yichao, S1
Hongbo, C1
Shenmin, Y1
Jiaxiong, W1
Hong, L1
Robertson, SA1
Jin, M1
Yu, D1
Moldenhauer, LM1
Davies, MJ1
Hull, ML1
Norman, RJ1
Drury, J1
Lash, GE1
Bulmer, JN1
Innes, BA1
Robson, SC1
Takakuwa, K3
Ishii, K1
Takaki, Y1
Natsume, N1
Adachi, H1
Kurata, H1
Tamura, M2
Kurabayasi, T1
Tanaka, K3
Farquharson, R2
Young, M1
Vince, G2
Kalumbi, C1
Bates, M1
Carbillon, L1
Thum, MY1
Bhaskaran, S1
Abdalla, HI1
Ford, B1
Sumar, N1
Bansal, A1
Perricone, R1
De Carolis, C1
Kröegler, B1
Greco, E1
Giacomelli, R1
Cipriani, P1
Fontana, L1
Perricone, C1
Hartikainen-Sorri, AL1
Kaila, J1
Ozaki, Y1
Aoki, K4
Aoyama, T3
Kunimatsu, M1
al-Momen, AK2
Moghraby, SA1
el-Rab, MO1
Gader, AM1
al-Balla, SR1
al-Meshari, AA1
al-Nuaim, L1
Someya, K1
Hosokawa, T1
Nemoto, T1
Iwasaki, S1
Nozawa, S1
Makino, T1
Murphy, MF1
Hambley, H1
Nicolaides, K1
Waters, AH1
Arakawa, M1
Honda, K1
Imai, T1
Kurabayashi, T1
Katano, K2
Ogasawara, M2
Suzumori, K2
Sasa, H1
Darmochwał-Kolarz, D1
Leszczyńska-Gorzelak, B1
Oleszczuk, J1
Ho, HN2
Melinda, S1
Lin, HH1
Hwang, JL2
Hsieh, CY2
Lee, TY1
Yoshida, A2
Morozumi, K2
Koyama, K1
Fukuda, M1
Oikawa, T1
Hasegawa, I1
Goto, S1
Yamada, K1
Sekizuka, N1
Kanazawa, K1
Sulimani, R1
Harakati, M1
Gader, AG1
Mekki, M1
Huang, LW1
Shen, MC1
Mizoguchi, K1
Kakisako, S1
Tanaka, M1
Yano, H1
Shimizu, T1
Gondoh, Y1
Shoji, H1
Kaji, M1
Gancel, A1
Courtois, H1
Doucet, J1
Schrub, JC1
Le Bouedec, G1
Fondrinier, E1
Sauvezie, B1
Bruhat, MA1
Suganuma, T1
Shinmura, I1
Fujinami, T1
Yagami, Y1
Svetlova, AK1
Rozovskiĭ, IS1
Stepanova, RA1
Golovatskaya, GI1
Tkachenko, NM1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intravenous Immunoglobulin and Prednisolone to Women With Unexplained Recurrent Pregnancy Loss After Assisted Reproductive Technology Treatment: a Randomised, Double-blind, Placebo-controlled Trial[NCT04701034]Phase 274 participants (Anticipated)Interventional2021-02-06Recruiting
Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss[NCT04558268]Phase 2/Phase 3242 participants (Anticipated)Interventional2020-12-31Not yet recruiting
A Three-arm, Multicenter, Open-label Randomized Controlled Trial of Hydroxychloroquine and Low-dose Prednisone on Recurrent Spontaneous Abortion With Undifferentiated Connective Tissue Diseases: Protocol for the Immunosuppressant Regimens for Living FEtus[NCT03671174]420 participants (Anticipated)Interventional2019-08-02Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for prednisolone and Abortion, Recurrent

ArticleYear
Oral immunosuppressants improve pregnancy outcomes in women with idiopathic recurrent miscarriage: A meta-analysis.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:7

    Topics: Abortion, Habitual; Cyclosporine; Female; Humans; Immunosuppressive Agents; Live Birth; Prednisolone

2022
Immunotherapy to improve pregnancy outcome in women with abnormal natural killer cell levels/activity and recurrent miscarriage or implantation failure: A systematic review and meta-analysis.
    Journal of reproductive immunology, 2020, Volume: 142

    Topics: Abortion, Habitual; Embryo Implantation; Emulsions; Etanercept; Female; Humans; Immunoglobulins, Int

2020
Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2015, Volume: 74, Issue:1

    Topics: Abortion, Habitual; Embryo Implantation; Female; Humans; Killer Cells, Natural; Leukocyte Count; Liv

2015
Corticosteroid therapy in assisted reproduction - immune suppression is a faulty premise.
    Human reproduction (Oxford, England), 2016, Volume: 31, Issue:10

    Topics: Abortion, Habitual; Embryo Implantation; Endometrium; Female; Humans; Immunosuppressive Agents; Pred

2016

Trials

6 trials available for prednisolone and Abortion, Recurrent

ArticleYear
Intravenous immunoglobulin and prednisolone to women with unexplained recurrent pregnancy loss after assisted reproductive technology treatment: a protocol for a randomised, double-blind, placebo-controlled trial.
    BMJ open, 2022, 09-22, Volume: 12, Issue:9

    Topics: Abortion, Habitual; Double-Blind Method; Female; Humans; Immunoglobulins, Intravenous; Prednisolone;

2022
A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant.
    Human reproduction (Oxford, England), 2013, Volume: 28, Issue:7

    Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Feasibility Studies; Female; Glucocorticoids; Huma

2013
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial.
    Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4

    Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th

2014
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial.
    Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4

    Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th

2014
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial.
    Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4

    Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th

2014
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial.
    Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4

    Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th

2014
Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.
    Trials, 2009, Nov-10, Volume: 10

    Topics: Abortion, Habitual; Clinical Protocols; Double-Blind Method; Endometrium; Female; Humans; Killer Cel

2009
Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion.
    Rheumatology (Oxford, England), 2008, Volume: 47, Issue:5

    Topics: Abortion, Habitual; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antibodies

2008
Effectiveness of prednisolone/aspirin therapy for recurrent aborters with antiphospholipid antibody.
    Human reproduction (Oxford, England), 1992, Volume: 7, Issue:2

    Topics: Abortion, Habitual; Adult; Antibodies; Antiphospholipid Syndrome; Aspirin; Cardiolipins; Drug Evalua

1992

Other Studies

28 other studies available for prednisolone and Abortion, Recurrent

ArticleYear
Successful treatment for a recurrent pregnancy loss woman with high Th1/Th2 ratio using medium-dose corticosteroids.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2017, Volume: 37, Issue:5

    Topics: Abortion, Habitual; Adrenal Cortex Hormones; Adult; CD4 Lymphocyte Count; Female; Fetal Death; Gesta

2017
Factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus.
    Journal of reproductive immunology, 2018, Volume: 125

    Topics: Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Complement Syste

2018
The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study.
    Journal of reproductive immunology, 2019, Volume: 131

    Topics: Abortion, Habitual; Adult; Embryo Implantation; Endometrium; Female; Humans; Killer Cells, Natural;

2019
Natural born killer.
    Midwives, 2014, Volume: 17, Issue:1

    Topics: Abortion, Habitual; Abortion, Spontaneous; Female; Glucocorticoids; Humans; Immunotherapy; Killer Ce

2014
Prednisolone treatment reduces endometrial spiral artery development in women with recurrent miscarriage.
    Angiogenesis, 2011, Volume: 14, Issue:4

    Topics: Abortion, Habitual; Actins; Adult; Angiogenesis Inducing Agents; Endometrium; Factor VIII; Female; H

2011
Effect of sairei-to combined with aspirin and prednisolone on four recurrent reproductive failure women who are positive for anti-phospholipid antibodies.
    The American journal of Chinese medicine, 2003, Volume: 31, Issue:4

    Topics: Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Aspirin; Drug Therapy, Combination; Drugs,

2003
Successful pregnancy outcome following 19 consecutive miscarriages: case report.
    Human reproduction (Oxford, England), 2003, Volume: 18, Issue:12

    Topics: Abortion, Habitual; Cell Count; Female; Humans; Killer Cells, Natural; Prednisolone; Pregnancy; Preg

2003
Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage.
    Fertility and sterility, 2005, Volume: 84, Issue:4

    Topics: Abortion, Habitual; Adult; Endometrium; Female; Fertilization; Humans; Killer Cells, Natural; Middle

2005
Intrarater variation--more studies are needed.
    Fertility and sterility, 2006, Volume: 85, Issue:2

    Topics: Abortion, Habitual; CD56 Antigen; Female; Humans; Killer Cells, Natural; Observer Variation; Prednis

2006
Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2008, Volume: 59, Issue:3

    Topics: Abortion, Habitual; Adult; Coculture Techniques; Cytotoxicity, Immunologic; Female; Humans; Immunogl

2008
Systemic lupus erythematosus and habitual abortion. Case report.
    British journal of obstetrics and gynaecology, 1980, Volume: 87, Issue:8

    Topics: Abortion, Habitual; Adult; Female; Heart Block; Humans; Infant, Newborn; Lupus Erythematosus, System

1980
Clinical significance of anti-GM3 antibodies in recurrent pregnancy loss with elevated level of antiphospholipid antibodies.
    American journal of reproductive immunology (New York, N.Y. : 1989), 1995, Volume: 33, Issue:3

    Topics: Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Aspirin; Drug Therapy, Combination; Female;

1995
Pregnancy outcome in women with antiphospholipid antibodies.
    Clinical rheumatology, 1993, Volume: 12, Issue:3

    Topics: Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Aspirin; Female; Humans; Immune System Dise

1993
[A case of beta 2-glycoprotein I-independent antiphospholipid syndrome].
    Nihon Sanka Fujinka Gakkai zasshi, 1995, Volume: 47, Issue:10

    Topics: Abortion, Habitual; Administration, Oral; Adult; Anti-Inflammatory Agents; Antibodies, Anticardiolip

1995
Severe fetomaternal alloimmune thrombocytopenia presenting with fetal hydrocephalus.
    Prenatal diagnosis, 1996, Volume: 16, Issue:12

    Topics: Abortion, Habitual; Abortion, Spontaneous; Anemia; Antigens, Human Platelet; Female; Fetal Diseases;

1996
Immunosuppressive therapy for recurrent aborters with positive antiphospholipid antibodies and alteration of 6ketoPGF1 alpha/TXB2 ratio.
    Journal of perinatal medicine, 1997, Volume: 25, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Aspirin; Drug

1997
Postpartum thrombosis after a successful pregnancy in a recurrent aborter strongly positive for antiphospholipid antibodies.
    Acta obstetricia et gynecologica Scandinavica, 1998, Volume: 77, Issue:3

    Topics: Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome;

1998
Recurrent abortion and moderate or strong antiphospholipid antibody production.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1998, Volume: 62, Issue:2

    Topics: Abortion, Habitual; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibo

1998
[Pregnancy after four recurrent pregnancy losses: a case report].
    Ginekologia polska, 2000, Volume: 71, Issue:6

    Topics: Abortion, Habitual; Adult; Anti-Inflammatory Agents; Antigens, CD; Asthma; Biomarkers; Female; HLA-D

2000
Treatment and outcome of unexplained recurrent spontaneous abortions in subclinical autoimmune disorders.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 1992, Volume: 91, Issue:5

    Topics: Abortion, Habitual; Antibodies, Antinuclear; Aspirin; Autoimmune Diseases; Female; Humans; Infant, N

1992
[Prednisolone and aspirin therapy for habitual abortion associated with anti-cardiolipin antibody].
    Ryumachi. [Rheumatism], 1992, Volume: 32, Issue:3

    Topics: Abortion, Habitual; Adult; Antiphospholipid Syndrome; Aspirin; Autoantibodies; Cardiolipins; Drug Th

1992
IgA antiphospholipid and adrenal insufficiency: is there a link?
    Thrombosis research, 1991, Dec-01, Volume: 64, Issue:5

    Topics: Abortion, Habitual; Addison Disease; Adult; Antiphospholipid Syndrome; Aphasia; Female; Hemiplegia;

1991
Recurrent fetal loss with circulating lupus anticoagulant: report of 2 cases.
    Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1989, Volume: 88, Issue:10

    Topics: Abortion, Habitual; Adult; Aspirin; Blood Coagulation Factors; Drug Therapy, Combination; Female; Hu

1989
Lupus anticoagulant as a risk factor for cerebral infarction and habitual abortions.
    The Kurume medical journal, 1989, Volume: 36, Issue:3

    Topics: Abortion, Habitual; Adult; Blood Coagulation Factors; Cerebral Infarction; Female; Hemiplegia; Human

1989
[Multiple fetal losses caused by a circulating anticoagulant. Correction with a combination of aspirin and corticotherapy].
    Presse medicale (Paris, France : 1983), 1986, Sep-20, Volume: 15, Issue:30

    Topics: Abortion, Habitual; Adult; Aspirin; Blood Coagulation; Female; Humans; Immunoglobulins; Prednisolone

1986
[Full term pregnancy and Soulier-Boffa syndrome].
    Presse medicale (Paris, France : 1983), 1988, Sep-10, Volume: 17, Issue:30

    Topics: Abortion, Habitual; Adult; Aspirin; Autoimmune Diseases; Drug Therapy, Combination; Female; Humans;

1988
[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].
    Ryumachi. [Rheumatism], 1988, Volume: 28, Issue:5

    Topics: Abortion, Habitual; Adult; Aspirin; Autoantibodies; Autoimmune Diseases; Drug Therapy, Combination;

1988
[Some clinical-physiological indices in children born of mothers with habitual abortion].
    Voprosy okhrany materinstva i detstva, 1971, Volume: 16, Issue:5

    Topics: Abortion, Habitual; Child; Child, Preschool; Congenital Abnormalities; Electroencephalography; Estro

1971