pre 084 has been researched along with Disease Models, Animal in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 16 (64.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Kadnikov, IA; Seredenin, SB; Voronin, MV; Voronkov, DN | 1 |
| Cao, T; Guo, CH; Waddington, JL; Zhen, XC; Zheng, LT | 1 |
| Barwick, SR; Smith, SB; Wang, J; Xiao, H | 1 |
| Hirooka, Y; Ito, K; Sunagawa, K | 1 |
| Griesmaier, E; Kiechl-Kohlendorfer, U; Krepp, Y; Posod, A; Stock, K; Urbanek, M | 1 |
| Bigini, P; Bontempi, L; Collina, S; Curti, D; Manzo, A; Petese, A; Peviani, M; Rossi, D; Salmona, M; Salvaneschi, E | 1 |
| Bez, F; Cenci, MA; Francardo, V; Nissbrandt, H; Ruscher, K; Wieloch, T | 1 |
| Chen, L; Hong, J; Sha, S; Wang, C; Yin, J; Zhou, L | 1 |
| Chen, J; Dong, H; Ma, Y; Ren, Z; Xu, B; Yang, B; Zhang, Y | 1 |
| Maurice, T | 1 |
| Cao, D; Fu, CH; Ji, LL; Li, D; Peng, JB; Tong, L; Wang, ZY | 1 |
| Baeyens, JM; Cobos, EJ; Entrena, JM; González-Cano, R; Nieto, FR; Sánchez-Fernández, C; Yeste, S | 1 |
| Beitz, AJ; Choi, HS; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 2 |
| Beitz, AJ; Han, HJ; Kim, HW; Kim, KW; Kwon, YB; Lee, JH; Roh, DH; Seo, HS; Yoon, SY | 2 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Del Pozo, E; Entrena, JM; Nieto, FR | 1 |
| Allahtavakoli, M; Jarrott, B | 1 |
| Hirooka, Y; Ito, K; Matsukawa, R; Nakano, M; Sunagawa, K | 1 |
| Casas, C; Mancuso, R; Navarro, X; Oliván, S; Osta, R; Rando, A | 1 |
| Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R; Orito, K | 1 |
| Chou, YC; Liao, JF; Liou, KT; Shen, YC; Wang, WY; Wang, YH; Yen, JC | 1 |
| Matsuno, K | 1 |
1 review(s) available for pre 084 and Disease Models, Animal
| Article | Year |
|---|---|
[Anti-amnesic effects of sigma (sigma)-receptor agonists].
Topics: Acetylcholine; Amnesia; Animals; Disease Models, Animal; Dopamine; Ligands; Mice; Morpholines; Pentazocine; Phenazocine; Piperazines; Receptors, sigma; Sigma-1 Receptor | 1999 |
24 other study(ies) available for pre 084 and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Chaperone Sigma1R mediates the neuroprotective action of afobazole in the 6-OHDA model of Parkinson's disease.
Topics: Animals; Benzimidazoles; Corpus Striatum; Disease Models, Animal; Dopamine; Ethylenediamines; Male; Mice; Mice, Inbred ICR; Morpholines; Neurons; Neuroprotection; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Substantia Nigra | 2019 |
Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson's disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; DEAD-box RNA Helicases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flavonols; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Morpholines; Oxidopamine; Parkinson Disease; Receptors, sigma; Ribonuclease III; Sigma-1 Receptor; Tamoxifen | 2020 |
Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP.
Topics: Animals; Catalase; Cell Line; Cell Survival; Disease Models, Animal; Electroretinography; Gene Expression Regulation; Ligands; Mice; Mice, Inbred C57BL; Morpholines; NAD(P)H Dehydrogenase (Quinone); Nootropic Agents; Oxidative Stress; Pentazocine; Piperazines; Receptors, sigma; Retina; Retinal Cone Photoreceptor Cells; Retinitis Pigmentosa; Sigma-1 Receptor; Superoxide Dismutase-1; Visual Acuity | 2020 |
Brain sigma-1 receptor stimulation improves mental disorder and cardiac function in mice with myocardial infarction.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cardiotonic Agents; Cognition Disorders; Depression; Disease Models, Animal; Heart; Hippocampus; Hypothalamus; Male; Memory Disorders; Mice; Mice, Inbred ICR; Morpholines; Myocardial Infarction; Nerve Tissue Proteins; Neurons; Nootropic Agents; Receptors, sigma; Sigma-1 Receptor; Ventricular Dysfunction | 2013 |
In vivo and in vitro evaluation of the effect of 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate on inflammation-sensitized hyperoxia-induced developing brain injury.
Topics: Animals; Blotting, Western; Brain Injuries; Disease Models, Animal; Fluorescent Antibody Technique; Hyperoxia; Immunohistochemistry; Inflammation; Morpholines; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor | 2013 |
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Locomotion; Male; Mice; Mice, Transgenic; Morpholines; Motor Neuron Disease; Motor Neurons; Mutation; Neuroglia; Neuroprotective Agents; Receptors, sigma; Sigma-1 Receptor; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Brain; Disease Models, Animal; Dopamine; Exploratory Behavior; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Oxidopamine; Parkinsonian Disorders; Psychomotor Performance; Receptors, sigma; Serotonin; Sigma-1 Receptor | 2014 |
Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anisoles; Astrocytes; Cell Death; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Morpholines; Neuroprotective Agents; Parkinson Disease, Secondary; Pars Compacta; Phenols; Phosphorylation; Piperidines; Propylamines; Psychomotor Performance; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Vesicular Monoamine Transport Proteins | 2015 |
Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Inflammation; Macrophage Activation; Macrophages; Mice, Inbred C57BL; Microglia; Morpholines; Neuroprotective Agents; Oxidative Stress; Receptors, sigma; Sigma-1 Receptor | 2016 |
Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments.
Topics: Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Furans; Indans; Male; Memantine; Memory Disorders; Mice; Morpholines; Neuroprotective Agents; Peptide Fragments; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2016 |
Activation of Sigma-1 receptor ameliorates anxiety-like behavior and cognitive impairments in a rat model of post-traumatic stress disorder.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Disease Models, Animal; Male; MAP Kinase Signaling System; Maze Learning; Morpholines; Motor Activity; Psychotropic Drugs; Rats, Sprague-Dawley; Receptor, trkB; Receptors, sigma; Sigma-1 Receptor; Spatial Memory; Stress Disorders, Post-Traumatic | 2016 |
Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.
Topics: Animals; Capsaicin; Cyclopentanes; Disease Models, Animal; Hyperalgesia; Liver; Male; Mice; Morpholines; Nociception; Pain Measurement; Pain Threshold; Pentazocine; Receptors, sigma; Sigma-1 Receptor | 2016 |
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Nerve Tissue Proteins; Neuralgia; Phosphorylation; Physical Stimulation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Spinal Cord | 2017 |
Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathway.
Topics: Animals; Antitussive Agents; Calcium Signaling; Cyclopentanes; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Inflammation Mediators; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Protein Kinase C; Proto-Oncogene Proteins c-fos; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Spinal Cord | 2008 |
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Brain; Capsaicin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Hyperalgesia; Mice; Morpholines; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pentazocine; Physical Stimulation; Protein Binding; Radioligand Assay; Reaction Time; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Tritium | 2009 |
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Brain Infarction; Cytokines; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Extremities; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Morpholines; Nervous System Diseases; Neuroprotective Agents; Rats; Rats, Wistar; Reaction Time; Regional Blood Flow; Time Factors; Touch | 2011 |
Decreased brain sigma-1 receptor contributes to the relationship between heart failure and depression.
Topics: Animals; Brain; Dehydroepiandrosterone Sulfate; Depression; Disease Models, Animal; Fluvoxamine; Heart Failure; Infusions, Intraventricular; Male; Mice; Mice, Inbred ICR; Morpholines; Piperazines; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor; Sympathetic Nervous System | 2012 |
Sigma-1R agonist improves motor function and motoneuron survival in ALS mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Cell Survival; Disease Models, Animal; Electrophysiology; Female; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Morpholines; Motor Activity; Motor Neurons; Neuroprotective Agents; Receptors, sigma; Sigma-1 Receptor; Superoxide Dismutase; Superoxide Dismutase-1 | 2012 |
Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Enzyme Inhibitors; Ethylenediamines; Hyperalgesia; Imidazoles; Male; Mice; Mice, Inbred ICR; Morpholines; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sciatica; Sigma-1 Receptor; Spinal Cord | 2013 |
Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine.
Topics: Animals; Behavior, Animal; Brain; Butyrates; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Fluvoxamine; Male; Mice; Mice, Inbred ICR; Morpholines; Obsessive-Compulsive Disorder; Paroxetine; Phenazocine; Piperazines; Psychotropic Drugs; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor; Tropanes | 2007 |
Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.
Topics: Analysis of Variance; Animals; Brain Infarction; Brain Ischemia; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Lipid Peroxidation; Male; Morphinans; Morpholines; NF-kappaB-Inducing Kinase; Nitric Oxide Synthase; Peroxidase; Protein Serine-Threonine Kinases; Rats; Rats, Long-Evans; Receptors, sigma; Reperfusion Injury; Sigma-1 Receptor; Signal Transduction; STAT1 Transcription Factor | 2008 |
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
Topics: Animals; Behavior, Animal; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Cyclopentanes; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Immunohistochemistry; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morpholines; N-Methylaspartate; Pain; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Serine; Sigma-1 Receptor; Signal Processing, Computer-Assisted; Signal Transduction; Spinal Cord; Time Factors | 2008 |