Page last updated: 2024-11-03

prazosin and Ventricular Dysfunction, Left

prazosin has been researched along with Ventricular Dysfunction, Left in 7 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.

Research Excerpts

ExcerptRelevanceReference
" The role of alpha(1)-adrenergic stimulation in myocardial TNF-alpha expression and depressed cardiac function after HS/R was assessed by treatment with the alpha(1)-adrenergic inhibitor, prazosin hydrochloride (1 mg/kg ip), for 1 h before the onset of hemorrhage."3.71Hemorrhage-induced alpha-adrenergic signaling results in myocardial TNF-alpha expression and contractile dysfunction. ( Klein, LV; Lindsay, TF; Marshall, JG; Nicholson, S; Rubin, BB; Shahani, R; Walker, PM, 2001)
"[3H]Prazosin binding was determined in arterial segments of Wistar-Kyoto rats (WKY), and of Wistar rats 5 weeks after myocardial infarction (MI) or sham operation (SHAM)."3.69Alpha 1-adrenoceptor subtypes in rat aorta and mesenteric small arteries are preserved during left ventricular dysfunction post-myocardial infarction. ( DeMey, JG; Janssen, GM; Stassen, FR; Willemsen, MJ, 1997)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Abdel Baseer, KA1
Aboelela, MG1
Qubaisy, HM1
Isabelle, M1
Monteil, C1
Moritz, F1
Dautreaux, B1
Henry, JP1
Richard, V1
Mulder, P1
Thuillez, C1
Stassen, FR1
Willemsen, MJ1
Janssen, GM1
DeMey, JG1
Grupp, IL1
Lorenz, JN1
Walsh, RA1
Boivin, GP1
Rindt, H1
Adigun, AQ1
Ajayi, OE1
Sofowora, GG1
Ajayi, AA1
Cohn, JN1
Shahani, R1
Klein, LV1
Marshall, JG1
Nicholson, S1
Rubin, BB1
Walker, PM1
Lindsay, TF1

Reviews

1 review available for prazosin and Ventricular Dysfunction, Left

ArticleYear
Left ventricle and arteries: structure, function, hormones, and disease.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2 Pt 2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arginine Vasopressin; Dr

2001

Trials

1 trial available for prazosin and Ventricular Dysfunction, Left

ArticleYear
Vasodilator therapy of hypertensive acute left ventricular failure: comparison of captopril-prazosin with hydralazine-isosorbide dinitrate.
    International journal of cardiology, 1998, Nov-30, Volume: 67, Issue:1

    Topics: Adult; Antihypertensive Agents; Captopril; Drug Therapy, Combination; Female; Humans; Hydralazine; H

1998

Other Studies

5 other studies available for prazosin and Ventricular Dysfunction, Left

ArticleYear
Echocardiographic Evaluation of the Response to Prazosin Treatment in Scorpion Sting.
    Journal of tropical pediatrics, 2021, 07-02, Volume: 67, Issue:3

    Topics: Adolescent; Child; Echocardiography; Humans; Male; Prazosin; Prospective Studies; Scorpion Stings; V

2021
Role of alpha1-adrenoreceptors in cocaine-induced NADPH oxidase expression and cardiac dysfunction.
    Cardiovascular research, 2005, Sep-01, Volume: 67, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Cardiomyopathies; Co

2005
Alpha 1-adrenoceptor subtypes in rat aorta and mesenteric small arteries are preserved during left ventricular dysfunction post-myocardial infarction.
    Cardiovascular research, 1997, Volume: 33, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Calcium Channel Blockers; Dihydropyridines; In Vitro T

1997
Overexpression of alpha1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Blood Pressure; Calcium; Cardiomegaly; Cells, Cult

1998
Hemorrhage-induced alpha-adrenergic signaling results in myocardial TNF-alpha expression and contractile dysfunction.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Hemorrhage; Male; Myocardial Contr

2001