prazosin has been researched along with Trypanosomiasis, African in 2 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human African trypanosomiasis (HAT) remains a health threat to sub-Saharan Africa." | 1.72 | Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis. ( Afrin, M; Hanna, J; Li, B; Li, Y; Marbury, M; Orahoske, CM; Su, B, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Orahoske, CM | 1 |
| Afrin, M | 1 |
| Li, Y | 1 |
| Hanna, J | 1 |
| Marbury, M | 1 |
| Li, B | 1 |
| Su, B | 1 |
| Khasar, S | 1 |
| Oriowo, MA | 1 |
2 other studies available for prazosin and Trypanosomiasis, African
| Article | Year |
|---|---|
Identification of Prazosin as a Potential Flagellum Attachment Zone 1(FAZ1) Inhibitor for the Treatment of Human African Trypanosomiasis.
Topics: Animals; Flagella; Humans; Prazosin; Proteomics; Trypanocidal Agents; Trypanosomiasis, African | 2022 |
Vascular smooth muscle sensitivity to noradrenaline is reduced during an infection with Trypanosoma brucei in rats and rabbits.
Topics: Animals; Arteries; Dose-Response Relationship, Drug; Histamine; Muscle, Smooth, Vascular; Norepineph | 1991 |