prazosin has been researched along with Syncope in 10 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a 71-year-old male patient who developed acute myocardial infarction (AMI) due to a dynamic left ventricular outflow tract obstruction induced by terazosin." | 7.83 | Myocardial infarction induced by oral terazosin in a patient with predisposing structural cardiomyopathy: case report. ( Ferrando-Castagnetto, F; Lluberas, N; Martínez, F; Vidal Margenat, A; Vignolo, G, 2016) |
| " In a four-trial, randomized placebo-controlled crossover experiment, 12 normotensive volunteers (aged 25 ± 1 yrs; mean ± SE) completed a 60° head-upward tilt (HUT; 15 min or until onset of presyncope) at 06:00 and 16:00 h, 90 min after the administration of either α(1)-blockade (prazosin, 1 mg/20 kg body weight) or placebo." | 5.16 | The effect of time-of-day and sympathetic α1-blockade on orthostatic tolerance. ( Ainslie, PN; Atkinson, G; Grant, EJ; Jones, H; Lewis, NC; Lucas, SJ, 2012) |
| "We describe a 71-year-old male patient who developed acute myocardial infarction (AMI) due to a dynamic left ventricular outflow tract obstruction induced by terazosin." | 3.83 | Myocardial infarction induced by oral terazosin in a patient with predisposing structural cardiomyopathy: case report. ( Ferrando-Castagnetto, F; Lluberas, N; Martínez, F; Vidal Margenat, A; Vignolo, G, 2016) |
| "Treatment of benign prostatic hyperplasia (BPH) with nonselective alpha1 antagonists such as terazosin, doxazosin, and prazosin results in blood pressure reduction due to vasodilation." | 3.71 | Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study. ( Chao, J; Chrischilles, E; Gilden, D; Kreder, KJ; Rubenstein, L; Shah, H, 2001) |
| "The safety of terazosin, an effective agent for the treatment of hypertension, was assessed by analyzing data from 1,006 hypertensive patients who were enrolled in short-term and/or long-term studies." | 3.67 | Overall safety of terazosin as an antihypertensive agent. ( Glassman, HN; Jordan, DC; Luther, RR; Sperzel, WD, 1986) |
| "Hence, paragangliomas are occasionally misdiagnosed, and this results in unanticipated intraoperative hypertensive crisis." | 1.56 | Micturition syncope secondary to urinary bladder paraganglioma. ( Cherian, KE; Johnson, JT; Kapoor, N; Paul, TV, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohyama, K | 1 |
| Hori, Y | 1 |
| Sugiura, M | 1 |
| Johnson, JT | 1 |
| Cherian, KE | 1 |
| Kapoor, N | 1 |
| Paul, TV | 1 |
| Vidal Margenat, A | 1 |
| Ferrando-Castagnetto, F | 1 |
| Martínez, F | 1 |
| Lluberas, N | 1 |
| Vignolo, G | 1 |
| Lewis, NC | 2 |
| Ainslie, PN | 2 |
| Atkinson, G | 2 |
| Jones, H | 2 |
| Grant, EJ | 2 |
| Lucas, SJ | 2 |
| Seideman, P | 1 |
| Grahnén, A | 1 |
| Haglund, K | 1 |
| Lindström, B | 1 |
| von Bahr, C | 1 |
| Rubin, P | 1 |
| Jackson, G | 1 |
| Blaschke, T | 1 |
| Ball, J | 1 |
| Chrischilles, E | 1 |
| Rubenstein, L | 1 |
| Chao, J | 1 |
| Kreder, KJ | 1 |
| Gilden, D | 1 |
| Shah, H | 1 |
| Sperzel, WD | 1 |
| Glassman, HN | 1 |
| Jordan, DC | 1 |
| Luther, RR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Systemic Alfuzosin and Tamsulosin Hydrochloride on Choroidal Thickness and Pupil Diameter Sizes in Cases With Benign Prostatic Hyperplasia[NCT03144596] | Phase 4 | 63 participants (Actual) | Interventional | 2015-10-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for prazosin and Syncope
| Article | Year |
|---|---|
The effect of time-of-day and sympathetic α1-blockade on orthostatic tolerance.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Blood Pressure; Circadian Rhythm; Cross-Over Studies | 2012 |
Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adult; Arterial Pressure; Blood Flow | 2013 |
8 other studies available for prazosin and Syncope
| Article | Year |
|---|---|
Evaluation of syncope association with α
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Doxazosin; Humans; Hypertension; Indoles; Male; Midd | 2019 |
Micturition syncope secondary to urinary bladder paraganglioma.
Topics: 3-Iodobenzylguanidine; Adrenergic alpha-1 Receptor Antagonists; Adult; Diagnosis, Differential; Diag | 2020 |
Myocardial infarction induced by oral terazosin in a patient with predisposing structural cardiomyopathy: case report.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Angina Pectoris; Cardiomyopathies; Coronary Angiograp | 2016 |
Prazosin dynamics in hypertension: relationship to plasma concentration.
Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Male; Middle | 1981 |
Studies on the clinical pharmacology of prazosin. II: The influence of indomethacin and of propranolol on the action and disposition of prazosin.
Topics: Adult; Blood Pressure; Drug Interactions; Endocrine Glands; Heart Rate; Humans; Indomethacin; Kineti | 1980 |
Symptomatic sinus bradycardia due to prazosin.
Topics: Bradycardia; Humans; Male; Middle Aged; Prazosin; Syncope | 1994 |
Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study.
Topics: Accidental Falls; Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Cohort Studies; Comor | 2001 |
Overall safety of terazosin as an antihypertensive agent.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Asthenia; Body Weight; Dizziness; Female; Hea | 1986 |