prazosin has been researched along with Seizures in 29 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice." | 7.69 | Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994) |
| "The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice." | 7.68 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| " The anticonvulsant effect of MK-801 was evaluated against limbic seizures (measured by EEG) induced by intrahippocampal injection of 120 nmol of quinolinic acid, an agonist of the N-methyl-D-aspartate-type receptors, in freely moving rats." | 7.67 | Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats. ( Caccia, S; Conti, I; Samanin, R; Serafini, R; Stasi, MA; Tridico, RV; Vezzani, A, 1989) |
| "Stimulation-evoked seizures produced dramatic bilateral increases in specific [3H]prazosin binding to alpha 1A + alpha 1B receptors and particularly to alpha 1B receptors in layers I-III of all cortical areas examined." | 5.29 | Spatiotemporal alterations of central alpha 1-adrenergic receptor binding sites following amygdaloid kindling seizures in the rat: autoradiographic studies using [3H]prazosin. ( Berkovic, SF; Burazin, TC; Gundlach, AL; Jenkins, TA, 1995) |
| "kainic acid were a decrease in noradrenaline and an increase in 5-hydroxyindoleacetic acid in the acute (3 h after kainic acid injection) suggesting strongly increased neurotransmitter turnover in noradrenergic and serotonergic neurons." | 5.27 | Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures. ( Baran, H; Hornykiewicz, O; Hörtnagl, H; Sapetschnig, G; Sperk, G, 1985) |
| " This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.77 | The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011) |
| "The effects of alpha-adrenoceptors agents on seizures induced by intraperitoneal administration of lidocaine (75 mg/kg) were studied in mice." | 3.70 | Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors. ( Altenburg, SP; Farah, MB, 1999) |
| " The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice." | 3.69 | Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994) |
| "The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice." | 3.68 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| "Death from cocaine intoxication results from one or more of the multiple mechanisms including seizures, cardiovascular collapse, or apnea." | 3.68 | Acute cocaine toxicity: the effect of agents in non-seizure-induced death. ( Albertson, TE; Derlet, RW; Tseng, CC, 1993) |
| " The anticonvulsant effect of MK-801 was evaluated against limbic seizures (measured by EEG) induced by intrahippocampal injection of 120 nmol of quinolinic acid, an agonist of the N-methyl-D-aspartate-type receptors, in freely moving rats." | 3.67 | Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats. ( Caccia, S; Conti, I; Samanin, R; Serafini, R; Stasi, MA; Tridico, RV; Vezzani, A, 1989) |
| "The preferential alpha 2-noradrenergic agonist clonidine dose-relatedly increased the onset of seizures and mortality times, and decreased severity in rats treated with D,L-allylglycine." | 3.66 | Alpha-noradrenaline modulation of D,L-allylgycine seizures. ( Ashton, D; Wauquier, A, 1981) |
| "Chronic sound or electroshock-induced seizures caused down regulation of beta-adrenoceptors in frontal cortex and in hippocampus from GEPR-9s." | 1.31 | Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats. ( Cheong, JH; Choi, CR; Dailey, JW; Jobe, PC; Ko, KH; Reith, ME; Ryu, JR; Seo, DO; Shin, CY, 2000) |
| "Stimulation-evoked seizures produced dramatic bilateral increases in specific [3H]prazosin binding to alpha 1A + alpha 1B receptors and particularly to alpha 1B receptors in layers I-III of all cortical areas examined." | 1.29 | Spatiotemporal alterations of central alpha 1-adrenergic receptor binding sites following amygdaloid kindling seizures in the rat: autoradiographic studies using [3H]prazosin. ( Berkovic, SF; Burazin, TC; Gundlach, AL; Jenkins, TA, 1995) |
| "Postdecapitation convulsions were analyzed in rats after the administration of a variety of adrenergic and serotonergic agents." | 1.27 | Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents. ( Gonzales, DA; Peroutka, SJ; Shapiro, M, 1987) |
| "The convulsions were also inhibited by oxyprothepin, zotepine or chlorpromazine but not by haloperidol." | 1.27 | Inhibition of post-decapitation convulsions in the rat by dibenzothiepin neuroleptics via alpha 1-adrenoceptor blockade. ( Fukuda, T; Furukawa, T; Hashizume, N; Kumagai, M; Matsuo, N; Nagashima, M; Nojima, H; Oguro, K; Yamada, K, 1988) |
| "kainic acid were a decrease in noradrenaline and an increase in 5-hydroxyindoleacetic acid in the acute (3 h after kainic acid injection) suggesting strongly increased neurotransmitter turnover in noradrenergic and serotonergic neurons." | 1.27 | Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures. ( Baran, H; Hornykiewicz, O; Hörtnagl, H; Sapetschnig, G; Sperk, G, 1985) |
| "[3H]clonidine binding was increased in the brainstem of the mutants, and to a lesser extent in the cerebral cortex, while it was slightly diminished in the hypothalamic area." | 1.27 | Altered postnatal ontogeny of alpha 1- and alpha 2-adrenoceptor binding sites in the brain of a convulsive mutant mouse (quaking). ( Baumann, N; Graillot, C; Le Saux, F; Maurin, Y, 1985) |
| " Chronic administration of antidepressant drugs: amitriptyline, imipramine and zimelidine augmented the PDC." | 1.26 | Postdecapitation convulsions in the rat measured with an Animex motility meter: relation to central alpha-adrenoceptors. ( Pilc, A; Vetulani, J, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (48.28) | 18.7374 |
| 1990's | 10 (34.48) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Shen, Y | 1 |
| Ma, HX | 1 |
| Lu, H | 1 |
| Zhao, HT | 1 |
| Sun, JL | 1 |
| Cheng, Y | 1 |
| Zhang, HH | 1 |
| Kruse, SW | 1 |
| Dayton, KG | 1 |
| Purnell, BS | 1 |
| Rosner, JI | 1 |
| Buchanan, GF | 1 |
| Moezi, L | 1 |
| Shafaroodi, H | 1 |
| Hojati, A | 1 |
| Dehpour, AR | 1 |
| Vetulani, J | 1 |
| Pilc, A | 1 |
| Ashton, D | 1 |
| Wauquier, A | 1 |
| Papanicolaou, J | 1 |
| Summers, RJ | 1 |
| Vajda, FJ | 1 |
| Louis, WJ | 1 |
| Simon, P | 2 |
| Chermat, R | 2 |
| Puech, AJ | 1 |
| Dolan, JG | 1 |
| Mushlin, AI | 1 |
| Bodjarian, N | 1 |
| Carpentier, P | 1 |
| Baubichon, D | 1 |
| Blanchet, G | 1 |
| Lallement, G | 1 |
| Gundlach, AL | 1 |
| Burazin, TC | 1 |
| Jenkins, TA | 1 |
| Berkovic, SF | 1 |
| Amabeoku, G | 1 |
| Chandomba, R | 1 |
| Amabeoku, GJ | 1 |
| Tseng, CC | 1 |
| Derlet, RW | 1 |
| Albertson, TE | 1 |
| Altenburg, SP | 1 |
| Farah, MB | 1 |
| Malinowska, B | 1 |
| Napiórkowska-Pawlak, D | 1 |
| Pawlak, R | 1 |
| Buczko, W | 1 |
| Göthert, M | 1 |
| Seo, DO | 1 |
| Shin, CY | 1 |
| Ryu, JR | 1 |
| Cheong, JH | 1 |
| Choi, CR | 1 |
| Dailey, JW | 1 |
| Reith, ME | 1 |
| Jobe, PC | 1 |
| Ko, KH | 1 |
| Lachapelle, F | 1 |
| Baumann, N | 3 |
| Maj, J | 1 |
| Rogóz, Z | 1 |
| Skuza, G | 1 |
| Sowińska, H | 1 |
| Tsuda, H | 1 |
| Ito, M | 1 |
| Oguro, K | 2 |
| Mutoh, K | 1 |
| Shiraishi, H | 1 |
| Shirasaka, Y | 1 |
| Mikawa, H | 1 |
| Popoli, P | 1 |
| Pezzola, A | 1 |
| Scotti de Carolis, A | 1 |
| Vezzani, A | 1 |
| Serafini, R | 1 |
| Stasi, MA | 1 |
| Caccia, S | 1 |
| Conti, I | 1 |
| Tridico, RV | 1 |
| Samanin, R | 1 |
| Peroutka, SJ | 1 |
| Gonzales, DA | 1 |
| Shapiro, M | 1 |
| Yamada, K | 1 |
| Matsuo, N | 1 |
| Kumagai, M | 1 |
| Nagashima, M | 1 |
| Nojima, H | 1 |
| Hashizume, N | 1 |
| Fukuda, T | 1 |
| Furukawa, T | 1 |
| Baran, H | 1 |
| Sperk, G | 1 |
| Hörtnagl, H | 1 |
| Sapetschnig, G | 1 |
| Hornykiewicz, O | 1 |
| Maurin, Y | 2 |
| Le Saux, F | 1 |
| Graillot, C | 2 |
| Jazrawi, SP | 1 |
| Horton, RW | 1 |
| Russell, RD | 1 |
| Stripling, JS | 1 |
29 other studies available for prazosin and Seizures
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest.
Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals | 2021 |
Effect of monoamine reuptake inhibition and α
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochl | 2019 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela | 2011 |
Postdecapitation convulsions in the rat measured with an Animex motility meter: relation to central alpha-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Brain; Imipramine; Male; Prazosin; Rat | 1982 |
Alpha-noradrenaline modulation of D,L-allylgycine seizures.
Topics: Allylglycine; Animals; Clonidine; Glycine; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred Strain | 1981 |
The relationship between alpha 2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Clonidine; Female; Male; Pentylenetetrazole; Prazosin; Ra | 1982 |
Pharmacological evidence of the stimulation of central alpha-adrenergic receptors.
Topics: Animals; Body Temperature Regulation; Brain; Hydroxamic Acids; Male; Mice; Mice, Quaking; Motor Acti | 1983 |
Hypertension, vascular headaches, and seizures after carotid endarterectomy. Case report and therapeutic considerations.
Topics: Carotid Arteries; Endarterectomy; Female; Humans; Hypertension; Middle Aged; Phenobarbital; Prazosin | 1984 |
Involvement of non-muscarinic receptors in phosphoinositide signalling during soman-induced seizures.
Topics: Animals; Chlorpheniramine; Dimethyl Sulfoxide; Electroencephalography; Inositol 1,4,5-Trisphosphate; | 1995 |
Spatiotemporal alterations of central alpha 1-adrenergic receptor binding sites following amygdaloid kindling seizures in the rat: autoradiographic studies using [3H]prazosin.
Topics: Amygdala; Animals; Autoradiography; Binding Sites; Cerebral Cortex; Diencephalon; Kindling, Neurolog | 1995 |
Strychnine-induced seizures in mice: the role of noradrenaline.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipram | 1994 |
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Dr | 1993 |
Acute cocaine toxicity: the effect of agents in non-seizure-induced death.
Topics: Animals; Anticonvulsants; Cocaine; Diazepam; Electrodes, Implanted; Electroencephalography; Male; Ni | 1993 |
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phe | 1999 |
Ifenprodil influences changes in mouse behaviour related to acute and chronic ethanol administration.
Topics: Animals; Behavior, Animal; Brain; Central Nervous System Depressants; Dose-Response Relationship, Dr | 1999 |
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
Topics: Animals; Dihydroalprenolol; Electroshock; Epilepsy; Norepinephrine; Oxidopamine; Prazosin; Rats; Rat | 2000 |
Anticonvulsant effect of yohimbine in quaking mice: antagonism by clonidine and prazosine.
Topics: Animals; Anticonvulsants; Clonidine; Male; Mice; Mice, Quaking; Phentolamine; Prazosin; Quinazolines | 1979 |
The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist.
Topics: Animals; Antidepressive Agents; Benzazepines; Citalopram; Dizocilpine Maleate; Fluoxetine; Imipramin | 1992 |
Involvement of the noradrenergic system in the seizures of epileptic El mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dihydroalprenolol; Drug Interactions; Female; Injections, | 1990 |
An EEG and behavioural study on the interactions of clonidine with phencyclidine and ketamine in rats.
Topics: Animals; Brain; Clonidine; Drug Interactions; Electroencephalography; Ketamine; Male; Muscle Tonus; | 1990 |
Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.
Topics: Animals; Anticonvulsants; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Electroencephalography; | 1989 |
Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Animals; Buspirone; Death; Dioxan | 1987 |
Inhibition of post-decapitation convulsions in the rat by dibenzothiepin neuroleptics via alpha 1-adrenoceptor blockade.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Dibenzothiep | 1988 |
Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures.
Topics: Animals; Brain Chemistry; Clonidine; Diazepam; Haloperidol; Kainic Acid; Male; Metergoline; Prazosin | 1985 |
Altered postnatal ontogeny of alpha 1- and alpha 2-adrenoceptor binding sites in the brain of a convulsive mutant mouse (quaking).
Topics: Animals; Brain; Brain Chemistry; Clonidine; Dihydroalprenolol; Female; Male; Mice; Mice, Inbred C57B | 1985 |
Modulation of alpha 1-and alpha 2-adrenoceptor binding sites in the brain of audiogenic seizure susceptible mice (DBA/2J).
Topics: Acoustic Stimulation; Animals; Brain; Clonidine; Dihydroalprenolol; Female; Kinetics; Male; Mice; Mi | 1985 |
Brain adrenoceptor binding sites in mice susceptible (DBA/2J) and resistant (C57 Bl/6) to audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Binding Sites; Brain; Clonidine; Dihydroalprenolol; Disease Susceptib | 1986 |
Monoaminergic and local anesthetic components of cocaine's effects on kindled seizure expression.
Topics: Amphetamine; Anesthetics, Local; Animals; Biogenic Amines; Cocaine; Drug Interactions; Haloperidol; | 1985 |