prazosin has been researched along with Pregnancy in 102 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether nifedipine or prazosin is the more appropriate second-line antihypertensive agent in pregnancy." | 9.09 | Nifedipine or prazosin as a second agent to control early severe hypertension in pregnancy: a randomised controlled trial. ( Hall, DR; Odendaal, HJ; Smith, M; Steyn, DW, 2000) |
| "Subjects were 11 patients who took prazosin during pregnancy and were counselled at the FRAME clinic in London Health Sciences Centre (Ontario, Canada) between 1 January 2000 and 31 December 2021." | 8.31 | Prospective evaluation of pregnancy outcomes after gestational exposure to prazosin. ( Campbell, MK; Garcia-Bournissen, F; Matsui, D; Zitoun, N, 2023) |
| "Prazosin is a selective peripheral alpha 1-adrenoceptor antagonist used in the treatment of hypertension and heart failure." | 7.68 | [Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases]. ( Bourget, P; Edouard, D; Fernandez, H; Frydman, R; Ribou, F, 1993) |
| "Prazosin (Minipress; Pfizer), the first purely alpha-blocking antihypertensive agent, was used to treat 22 pregnant patients with moderately severe hypertension (diastolic blood pressure persistently above 95 mmHg at gestational ages ranging from 18 to 33 weeks)." | 7.66 | Prazosin and oxprenolol therapy in pregnancy hypertension. ( Davey, DA; Dommisse, J; Roos, PJ, 1983) |
| "The combination of prazosin (3-21 mg/day) and oxprenolol (60-360 mg/day) was used to treat 25 pregnant women with severe essential hypertension and 19 women with the hypertension-oedema-proteinuria syndrome." | 7.66 | Combined alpha- and beta-adrenoceptor antagonism with prazosin and oxprenolol in control of severe hypertension in pregnancy. ( Hodge, JV; Lubbe, WF, 1981) |
| "The disposition and effect of orally administered prazosin have been studied in eight women with hypertension which was uncontrolled by beta-adrenoceptor blockade during the last trimester of pregnancy." | 7.66 | Clinical pharmacological studies with prazosin during pregnancy complicated by hypertension. ( Butters, L; Low, RA; Reid, JL; Rubin, PC, 1983) |
| "We conducted an uncontrolled study of the efficacy of prazosin in the treatment of hypertension in 45 patients." | 7.65 | Prazosin alone and combined with a thiazide diuretic in the treatment of hypertension. ( Bhoola, R; Seedat, MA; Seedat, YK, 1977) |
| "Pheochromocytoma is a rare disease that may occur during pregnancy." | 5.30 | Pheochromocytoma in pregnancy manifesting hypertensive crisis induced by metoclopramide. ( Kinoshita, K; Seki, H; Takai, Y, 1997) |
| "To determine whether nifedipine or prazosin is the more appropriate second-line antihypertensive agent in pregnancy." | 5.09 | Nifedipine or prazosin as a second agent to control early severe hypertension in pregnancy: a randomised controlled trial. ( Hall, DR; Odendaal, HJ; Smith, M; Steyn, DW, 2000) |
| "Subjects were 11 patients who took prazosin during pregnancy and were counselled at the FRAME clinic in London Health Sciences Centre (Ontario, Canada) between 1 January 2000 and 31 December 2021." | 4.31 | Prospective evaluation of pregnancy outcomes after gestational exposure to prazosin. ( Campbell, MK; Garcia-Bournissen, F; Matsui, D; Zitoun, N, 2023) |
| "We treated C57BL/6NCrl female mice with the α1-adrenergic antagonist prazosin during pregnancy and analyzed the male and female offspring for endocrine and metabolic abnormalities." | 3.85 | Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy. ( Geissler, C; Harder, L; Herrmann, B; Kirchner, H; Koch, C; Lehnert, H; Mittag, J; Oelkrug, R; Oster, H, 2017) |
| " To test the hypothesis that hypoxia-induced developmental and vessel specific cerebral artery contractility changes are mediated, in part, by changes in alpha1-adrenergic receptor (alpha1-AR) density and/or NE-induced inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] responses, we performed the following study." | 3.69 | High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries. ( Longo, LD; Ueno, N; Zhang, L; Zhao, Y, 1997) |
| "Receptor autoradiography using (-)-3-[125I]cyanopindolol and [3H]prazosin was used to study the distribution of beta and alpha-1 adrenoceptors in the rat uterus at early and midpregnancy." | 3.68 | Selective distribution of alpha-1 and beta adrenoceptors in pregnant rat uterus visualized by autoradiography. ( Legrand, C; Maltier, JP; Rigolot, C; Vivat, V, 1991) |
| "Prazosin is a selective peripheral alpha 1-adrenoceptor antagonist used in the treatment of hypertension and heart failure." | 3.68 | [Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases]. ( Bourget, P; Edouard, D; Fernandez, H; Frydman, R; Ribou, F, 1993) |
| "Myometrial biopsies from 80 women, delivered by cesarean section in 26-42 completed weeks of pregnancy, were analyzed using radiolabeled alpha 1-antagonist [3H]-prazosin and alpha 2-antagonist [3H]-rauwolscine." | 3.68 | Alpha-adrenergic receptors in human myometrium: changes during pregnancy. ( Andersson, RG; Berg, G; Dahle, LO; Hurtig, M; Rydén, G, 1993) |
| " To investigate the implication of these adrenergic receptors in uterine reactivity near term delivery, we have measured the number and the affinity of alpha 1-adrenergic antagonist [( 3H]prazosin: [3H]PRAZ)-binding sites and of very high affinity beta 2-adrenergic agonist [( 3H]hydroxybenzylisoproterenol: [3H]HBI)-binding sites in myometrial membranes throughout the last 5 days of pregnancy and at delivery." | 3.67 | Rat myometrial adrenergic receptors in late pregnancy. ( Benghan-Eyene, Y; Legrand, C; Maltier, JP, 1987) |
| "Metastatic pheochromocytoma, a rare complication of pregnancy, was managed from 30 weeks' gestation until delivery three weeks later with a combination of alpha-adrenergic blockade (Minipres) beta-adrenergic blockade (Timolol), and dopamine synthesis inhibition (Demser)." | 3.67 | Metastatic pheochromocytoma in pregnancy and fetal biophysical assessment after maternal administration of alpha-adrenergic, beta-adrenergic, and dopamine antagonists. ( Castillo, RA; Devoe, LD; Hadi, HA; O'Dell, BE; Searle, N, 1986) |
| "The combination of prazosin (3-21 mg/day) and oxprenolol (60-360 mg/day) was used to treat 25 pregnant women with severe essential hypertension and 19 women with the hypertension-oedema-proteinuria syndrome." | 3.66 | Combined alpha- and beta-adrenoceptor antagonism with prazosin and oxprenolol in control of severe hypertension in pregnancy. ( Hodge, JV; Lubbe, WF, 1981) |
| "Prazosin (Minipress; Pfizer), the first purely alpha-blocking antihypertensive agent, was used to treat 22 pregnant patients with moderately severe hypertension (diastolic blood pressure persistently above 95 mmHg at gestational ages ranging from 18 to 33 weeks)." | 3.66 | Prazosin and oxprenolol therapy in pregnancy hypertension. ( Davey, DA; Dommisse, J; Roos, PJ, 1983) |
| "The disposition and effect of orally administered prazosin have been studied in eight women with hypertension which was uncontrolled by beta-adrenoceptor blockade during the last trimester of pregnancy." | 3.66 | Clinical pharmacological studies with prazosin during pregnancy complicated by hypertension. ( Butters, L; Low, RA; Reid, JL; Rubin, PC, 1983) |
| " during different phases of the menstrual cycle, in postmenopausal women, term pregnancy, and during depo-progestin (medroxyprogesterone acetate) therapy." | 3.66 | Differential regulation of alpha-adrenergic receptor subclasses by gonadal steroids in human myometrium. ( Bottari, SP; Kaivez, E; Lescrainier, JP; Vauquelin, GP; Vokaer, A, 1983) |
| "We conducted an uncontrolled study of the efficacy of prazosin in the treatment of hypertension in 45 patients." | 3.65 | Prazosin alone and combined with a thiazide diuretic in the treatment of hypertension. ( Bhoola, R; Seedat, MA; Seedat, YK, 1977) |
| " These drugs must be administered parenterally and have a half-life of only a few minutes." | 2.40 | Clinical pharmacokinetics of vasodilators. Part II. ( Heintz, B; Kirsten, D; Kirsten, R; Nelson, K, 1998) |
| "Pre-eclampsia is still a very prevalent disease with critical hemodynamic changes." | 1.38 | Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. ( Albarran, HA; Rodriguez, GC; Zeron, HM, 2012) |
| " However, by means of pharmacokinetic modeling we describe the inverse correlation between lipid solubility of a molecule and its active transport by placental ABC efflux transporters." | 1.35 | Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility. ( Ceckova, M; Cygalova, LH; Hofman, J; Staud, F, 2009) |
| " Dose-response curves were constructed for NE with and without the addition of the alpha-adrenergic antagonist prazosin, EPI (after 20%-30% preconstruction with the thromboxane analog U46619) with and without the addition of the beta-adrenergic antagonist propranolol, and NE in the presence of 10(-8) M EPI." | 1.35 | The effect of maternal catecholamines on the caliber of gravid uterine microvessels. ( Segal, S; Wang, SY, 2008) |
| "Pheochromocytoma is a rare disease that may occur during pregnancy." | 1.30 | Pheochromocytoma in pregnancy manifesting hypertensive crisis induced by metoclopramide. ( Kinoshita, K; Seki, H; Takai, Y, 1997) |
| "Pregnancy is associated with an antinociception that is multifactorial and results from spinal (kappa/delta) opioid antinociceptive pathways as well as peripheral processes (ovarian sex steroids, uterine afferent neurotransmission)." | 1.30 | Gestational and ovarian sex steroid antinociception: relevance of uterine afferent and spinal alpha(2)-noradrenergic activity. ( Gintzler, AR; Liu, NJ, 1999) |
| "Phentolamine leads to an increase in FBM by preferentially antagonizing presynaptic alpha 2-adrenoreceptors over postsynaptic alpha 1-adrenoreceptors." | 1.29 | Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero. ( Bennet, L; Giussani, DA; Hanson, MA; Moore, PJ; Spencer, JA, 1995) |
| " The norepinephrine dose-response curves were shifted to the right and the concentrations at which 50% of the maximal response was attained were increased 3." | 1.29 | Effects of long-term high-altitude hypoxemia on alpha 1-adrenergic receptors in the ovine uterine artery. ( Gilbert, RD; Hu, XQ; Longo, LD; Zhang, L, 1996) |
| " The dose-response relationship of cocaine with fetal development was established in CF-1 mice by administering cocaine sc on days 5 to 18 of gestation followed by teratologic evaluation." | 1.28 | Antagonism of cocaine-induced fetal anomalies by prazosin and diltiazem in mice. ( Hitner, HW; Mahalik, MP, 1992) |
| "Hydralazine failed to inhibit responses to any of the agonists tested in the fetal and maternal arteries." | 1.28 | Effects of vasodilators on isolated human uteroplacental arteries. ( Allen, J; Forman, A; Maigaard, S; Skajaa, K, 1991) |
| "Oxytocin was infused for 60 min into the jugular vein of 8 lactating cows with full udders before milking." | 1.27 | Effect of prazosin on the function of the teat sphincter in lactating cows. ( Bernabé, J; Burvenich, C; Peeters, G; Vandeputte-Van Messom, G, 1984) |
| "Indomethacin pretreatment resulted in attenuation, but not suppression of contractile activity." | 1.27 | Effects of prazosin and indomethacin on the alpha-adrenergic stimulation of rabbit myometrium. ( Barss, VA; Phillippe, M; Valles, L, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (43.14) | 18.7374 |
| 1990's | 40 (39.22) | 18.2507 |
| 2000's | 12 (11.76) | 29.6817 |
| 2010's | 5 (4.90) | 24.3611 |
| 2020's | 1 (0.98) | 2.80 |
| Authors | Studies |
|---|---|
| Zitoun, N | 1 |
| Campbell, MK | 1 |
| Matsui, D | 1 |
| Garcia-Bournissen, F | 1 |
| Oelkrug, R | 1 |
| Herrmann, B | 1 |
| Geissler, C | 1 |
| Harder, L | 1 |
| Koch, C | 1 |
| Lehnert, H | 1 |
| Oster, H | 1 |
| Kirchner, H | 1 |
| Mittag, J | 1 |
| Spradley, FT | 1 |
| Ge, Y | 1 |
| Haynes, BP | 1 |
| Granger, JP | 1 |
| Anderson, CD | 1 |
| Castro, AE | 1 |
| Benitez, SG | 1 |
| Farias Altamirano, LE | 1 |
| Savastano, LE | 1 |
| Patterson, SI | 1 |
| Muñoz, EM | 1 |
| Abramova, MA | 2 |
| Ugryumov, MV | 1 |
| Kalas, A | 1 |
| Cygalova, LH | 1 |
| Hofman, J | 1 |
| Ceckova, M | 1 |
| Staud, F | 1 |
| Calas, A | 1 |
| Ugrumov, M | 1 |
| Rodriguez, GC | 1 |
| Albarran, HA | 1 |
| Zeron, HM | 1 |
| Xiao, D | 1 |
| Huang, X | 1 |
| Pearce, WJ | 1 |
| Longo, LD | 4 |
| Zhang, L | 5 |
| Tolbert, LM | 1 |
| Russell, DS | 1 |
| Duman, RS | 1 |
| Choong, KC | 1 |
| Shen, RY | 1 |
| Ontsouka, EC | 1 |
| Zbinden, Y | 1 |
| Hammon, HM | 1 |
| Blum, JW | 1 |
| Pérez, H | 2 |
| Ruiz, S | 2 |
| Núñez, H | 2 |
| White, A | 2 |
| Gotteland, M | 2 |
| Hernández, A | 1 |
| Segal, S | 1 |
| Wang, SY | 1 |
| Ambrosio, E | 1 |
| Montero, MT | 1 |
| Fernandez, I | 1 |
| Azuara, MC | 1 |
| Orensanz, LM | 1 |
| Gardey-Levassort, C | 1 |
| Ventura, MA | 1 |
| Thiroux, G | 1 |
| Olive, G | 1 |
| Lubbe, WF | 3 |
| Hodge, JV | 2 |
| Vandeputte-Van Messom, G | 3 |
| Bernabé, J | 2 |
| Burvenich, C | 3 |
| Peeters, G | 3 |
| Dausse, JP | 1 |
| Le Quan-Bui, KH | 1 |
| Meyer, P | 1 |
| Zwierzina, WD | 1 |
| Kunz, F | 1 |
| Judmaier, G | 1 |
| Mikuz, G | 1 |
| Gattringer, K | 1 |
| Bottari, SP | 1 |
| Vokaer, A | 1 |
| Kaivez, E | 1 |
| Lescrainier, JP | 1 |
| Vauquelin, GP | 1 |
| Rovinski, B | 1 |
| Hosein, EA | 1 |
| Lee, H | 1 |
| Ram, CV | 1 |
| Venuto, R | 1 |
| Burstein, P | 1 |
| Schneider, R | 1 |
| Rubin, PC | 2 |
| Butters, L | 1 |
| Low, RA | 1 |
| Reid, JL | 1 |
| Dommisse, J | 1 |
| Davey, DA | 1 |
| Roos, PJ | 1 |
| Kellaway, GS | 1 |
| Berkowitz, RL | 1 |
| Hu, XQ | 3 |
| Giussani, DA | 1 |
| Moore, PJ | 1 |
| Bennet, L | 1 |
| Spencer, JA | 1 |
| Hanson, MA | 1 |
| Jovanović, A | 1 |
| Grbović, L | 1 |
| Jovanović, S | 1 |
| Falkay, G | 4 |
| Kovács, L | 2 |
| Inayatulla, A | 1 |
| Li, DY | 1 |
| Chemtob, S | 1 |
| Varma, DR | 1 |
| Ueda, F | 1 |
| Ideguchi, K | 1 |
| Taniguchi, N | 1 |
| Kimura, K | 1 |
| Héry, M | 1 |
| François-Bellan, AM | 1 |
| Deprez, P | 1 |
| Faudon, M | 1 |
| Héry, F | 1 |
| Bourget, P | 1 |
| Fernandez, H | 1 |
| Ribou, F | 1 |
| Edouard, D | 1 |
| Frydman, R | 1 |
| Dahle, LO | 2 |
| Andersson, RG | 1 |
| Berg, G | 2 |
| Hurtig, M | 1 |
| Rydén, G | 1 |
| Monga, M | 1 |
| Weisbrodt, NW | 1 |
| Andres, RL | 1 |
| Sanborn, BM | 1 |
| al-Damluji, S | 1 |
| Krsmanovic, LZ | 1 |
| Catt, KJ | 1 |
| Parker, SL | 1 |
| Crowley, WR | 1 |
| Shi, CZ | 1 |
| Zhuang, LZ | 1 |
| Hurst, JA | 1 |
| Houlston, RS | 1 |
| Roberts, A | 1 |
| Gould, SJ | 1 |
| Tingey, WG | 1 |
| Gilbert, RD | 1 |
| Abe-Dohmae, S | 1 |
| Takagi, Y | 1 |
| Harada, N | 1 |
| Ueno, N | 1 |
| Zhao, Y | 1 |
| Dyer, DC | 2 |
| Chittacharoen, A | 1 |
| Phuapradit, W | 1 |
| Takai, Y | 1 |
| Seki, H | 1 |
| Kinoshita, K | 1 |
| Hall, DR | 4 |
| Odendaal, HJ | 4 |
| Adolfsson, PI | 1 |
| Svensson, SP | 1 |
| Hurd, WW | 1 |
| Betz, AL | 1 |
| Dombrowski, MP | 1 |
| Fomin, VP | 1 |
| Kirsten, R | 1 |
| Nelson, K | 1 |
| Kirsten, D | 1 |
| Heintz, B | 1 |
| Hu, X | 1 |
| Zupkó, I | 1 |
| Márki, A | 1 |
| Gáspár, R | 1 |
| Bakheet, DM | 1 |
| El Tahir, KE | 1 |
| Al-Sayed, MI | 1 |
| El-Obeid, HA | 1 |
| Al-Rashood, KA | 1 |
| Liu, NJ | 1 |
| Gintzler, AR | 1 |
| Jahn, GA | 1 |
| Kalia, V | 1 |
| Hole, D | 1 |
| Wilson, CA | 1 |
| Deis, RP | 1 |
| Steyn, DW | 2 |
| Smith, M | 1 |
| Grové, D | 2 |
| Kirsten, GF | 1 |
| Smith, J | 1 |
| Seedat, YK | 1 |
| Seedat, MA | 1 |
| Bhoola, R | 1 |
| Bento, AC | 1 |
| de Moraes, S | 1 |
| Mahalik, MP | 1 |
| Hitner, HW | 1 |
| Breuiller-Fouche, M | 1 |
| Doualla-Bell Kotto Maka, F | 1 |
| Geny, B | 1 |
| Ferre, F | 1 |
| Reviriego, J | 1 |
| Fernandez-Alfonso, MS | 1 |
| Guerra, P | 1 |
| Marín, J | 1 |
| Vass-Lopez, A | 1 |
| Garcia-Villar, R | 1 |
| Lafontan, M | 1 |
| Toutain, PL | 1 |
| Legrand, C | 7 |
| Vivat, V | 1 |
| Rigolot, C | 2 |
| Maltier, JP | 7 |
| Isla, M | 1 |
| Allen, J | 1 |
| Skajaa, K | 1 |
| Maigaard, S | 1 |
| Forman, A | 1 |
| Shaul, PW | 1 |
| Magness, RR | 1 |
| Muntz, KH | 1 |
| DeBeltz, D | 1 |
| Buja, LM | 1 |
| Arkinstall, SJ | 1 |
| Jones, CT | 1 |
| Petit, I | 1 |
| Banuelos-Nevarez, A | 2 |
| Benghan-Eyene, Y | 1 |
| Fallgren, B | 1 |
| Bjellin, L | 1 |
| Edvinsson, L | 1 |
| Mgaloblishvili, IB | 2 |
| Durando, C | 1 |
| Leidi, L | 1 |
| Margaria, E | 1 |
| Medaglia, M | 1 |
| Gessa, M | 1 |
| Maina, G | 1 |
| Devoe, LD | 1 |
| O'Dell, BE | 1 |
| Castillo, RA | 1 |
| Hadi, HA | 1 |
| Searle, N | 1 |
| Walters, DE | 1 |
| Carr, LA | 1 |
| Strizhakov, AN | 1 |
| Bunin, AT | 1 |
| Minasova, GS | 1 |
| Shakhonina, DA | 1 |
| Schoepp, DD | 1 |
| Rutledge, CO | 1 |
| Jacobs, MM | 1 |
| Hayashida, D | 1 |
| Roberts, JM | 1 |
| Konno, A | 1 |
| Terada, N | 1 |
| Okamoto, Y | 1 |
| McCaughran, JA | 1 |
| Juno, CJ | 1 |
| Friedman, R | 1 |
| Wood, M | 1 |
| Prud'Homme, MJ | 1 |
| Barss, VA | 1 |
| Phillippe, M | 1 |
| Valles, L | 1 |
| Ugen, KE | 1 |
| Scott, WJ | 1 |
| Redgrave, JE | 1 |
| Swartz, SL | 1 |
| Pinaud, M | 1 |
| Souron, R | 1 |
| Le Neel, JC | 1 |
| Lopes, P | 1 |
| Murat, A | 1 |
| L'hoste, F | 1 |
5 reviews available for prazosin and Pregnancy
| Article | Year |
|---|---|
Hypertensive crisis.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1984 |
Anti-hypertensive drugs in the pregnant patient.
Topics: Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Diuretics; Female; Fetus; Furosemide | 1980 |
Clinical pharmacokinetics of vasodilators. Part II.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Alprostadil; Amrinone; Carbazoles; Carvedilo | 1998 |
Treatment of hypertension in pregnancy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Eclampsia; Female; Human | 1986 |
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca | 1986 |
2 trials available for prazosin and Pregnancy
| Article | Year |
|---|---|
The addition of a diuretic to anti-hypertensive therapy for early severe hypertension in pregnancy.
Topics: Adult; Amiloride; Antihypertensive Agents; Diuretics; Drug Combinations; Drug Therapy, Combination; | 1998 |
Nifedipine or prazosin as a second agent to control early severe hypertension in pregnancy: a randomised controlled trial.
Topics: Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hypertension; Ni | 2000 |
95 other studies available for prazosin and Pregnancy
| Article | Year |
|---|---|
Prospective evaluation of pregnancy outcomes after gestational exposure to prazosin.
Topics: Female; Humans; Infant, Newborn; London; Ontario; Prazosin; Pregnancy; Pregnancy Outcome; Premature | 2023 |
Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy.
Topics: Adipose Tissue, Brown; Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Newborn; Dwarfism; | 2017 |
Adrenergic receptor blockade attenuates placental ischemia-induced hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Femal | 2018 |
Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Basic Helix-Loop-Helix Transcrip | 2015 |
Vasopressinergic neurons in rats in ontogenesis: responses to salt loading and their modulation by noradrenergic afferents.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Regulation; Female; Gene Expression Regulation, Deve | 2008 |
Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, | 2009 |
Vasopressinergic neurons of the supraoptic nucleus in perinatal rats: reaction to osmotic stimulation and its regulation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Newborn; Female; Fetal Development; Gene | 2011 |
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia.
Topics: Adolescent; Adult; Amlodipine; Antihypertensive Agents; Benzimidazoles; Benzoates; Blood Pressure; C | 2012 |
Effect of cortisol on norepinephrine-mediated contractions in ovine uterine arteries.
Topics: Animals; Arteries; Calcium; Drug Synergism; Female; Hydrocortisone; Inositol 1,4,5-Trisphosphate; Mu | 2003 |
Norepinephrine activates extracellular-regulated kinase in cortical neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 2003 |
Methylphenidate restores ventral tegmental area dopamine neuron activity in prenatal ethanol-exposed rats by augmenting dopamine neurotransmission.
Topics: Amphetamine; Animals; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Elec | 2004 |
Ontogenesis of mRNA levels and binding sites of hepatic alpha-adrenoceptors in young cattle.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Binding, Competitive; Blood Glucose; Cattle | 2006 |
Paraventricular-coerulear interactions: role in hypertension induced by prenatal undernutrition in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Corticotropin-Releasing Hormone; Diet | 2006 |
Coerulear activation by crh and its role in hypertension induced by prenatal malnutrition in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Corticosterone; Corticotropin-Releasi | 2007 |
The effect of maternal catecholamines on the caliber of gravid uterine microvessels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; Ad | 2008 |
[3H]prazosin binding to central nervous system regions of male and female rats.
Topics: Animals; Central Nervous System; Estrus; Female; Male; Prazosin; Pregnancy; Quinazolines; Rats; Rats | 1984 |
An attempt to identify alpha-adrenoceptors in the human placenta.
Topics: Binding Sites; Clonidine; Dihydroergotoxine; Female; Humans; Kinetics; Placenta; Prazosin; Pregnancy | 1984 |
Combined alpha- and beta-adrenoceptor antagonism with prazosin and oxprenolol in control of severe hypertension in pregnancy.
Topics: Acute Disease; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Drug Therapy, Combination | 1981 |
Effects of alpha-blocking agents on teat motility in lactating cows.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; Female; In Vitro Techniques; Lactation; Mammary Gland | 1982 |
Effect of neonatal 6-hydroxydopamine treatment on alpha 1- and alpha 2-adrenoceptors in rat cerebral cortex.
Topics: Aging; Animals; Animals, Newborn; Brain; Clonidine; Female; Hydroxydopamines; Kinetics; Prazosin; Pr | 1982 |
[Acute fatty liver in pregnancy with consumption coagulopathy].
Topics: Acute Disease; Adult; Ampicillin; Ascites; Disseminated Intravascular Coagulation; Electrolytes; Fat | 1983 |
Differential regulation of alpha-adrenergic receptor subclasses by gonadal steroids in human myometrium.
Topics: Binding, Competitive; Estradiol; Estrogens; Female; Humans; Medroxyprogesterone; Medroxyprogesterone | 1983 |
Effect of maternal ethanol ingestion during pregnancy and lactation on the structure and function of the postnatal rat liver plasma membrane. Assessement with [3H]prazosin binding to the hepatic alpha 1-adrenergic receptors.
Topics: Animals; Cell Membrane; Diet; Ethanol; Female; Lactation; Liver; Maternal-Fetal Exchange; Prazosin; | 1984 |
Pheochromocytoma: antepartum diagnosis and management with tumor resection in the puerperium.
Topics: Adrenal Gland Neoplasms; Adult; Combined Modality Therapy; Female; Humans; Metoprolol; Pheochromocyt | 1984 |
Action of epinephrine on the function of the teat sphincter in the lactating cow.
Topics: Animals; Cattle; Drug Interactions; Epinephrine; Female; Injections, Intra-Arterial; Lactation; Mamm | 1984 |
Clinical pharmacological studies with prazosin during pregnancy complicated by hypertension.
Topics: Adolescent; Adult; Female; Humans; Hypertension; Prazosin; Pregnancy; Pregnancy Complications, Cardi | 1983 |
Effect of prazosin on the function of the teat sphincter in lactating cows.
Topics: Animals; Cattle; Female; Injections, Intra-Arterial; Injections, Intravenous; Lactation; Mammary Gla | 1984 |
Prazosin and oxprenolol therapy in pregnancy hypertension.
Topics: Blood Pressure; Drug Therapy, Combination; Female; Humans; Hypertension; Oxprenolol; Prazosin; Pregn | 1983 |
Prazosin hydrochloride.
Topics: Adult; Animals; Child; Dogs; Female; Humans; Hypertension; Male; Prazosin; Pregnancy; Quinazolines | 1980 |
Antihypertensive treatment and fetal welfare in essential hypertension in pregnancy: a retrospective survey of experience with various regimes at National Women's Hospital, Auckland, 1970-80.
Topics: Antihypertensive Agents; Bed Rest; Benzothiadiazines; Birth Weight; Diuretics; Drug Therapy, Combina | 1982 |
The management of hypertension in pregnancy.
Topics: Adult; Dihydralazine; Drug Therapy, Combination; Female; Humans; Hypertension; Oxprenolol; Prazosin; | 1981 |
Serotonin stimulates rapid increase of inositol 1,4,5-trisphosphate in ovine uterine artery: correlation with contractile state.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Calcium; Female; Inositol 1,4,5-Trisphosphate; Keta | 1995 |
Alpha 1- and alpha 2-adrenoreceptor actions of phentolamine and prazosin on breathing movements in fetal sheep in utero.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 1995 |
Effect of the vascular endothelium on noradrenaline-induced contractions in non-pregnant and pregnant guinea-pig uterine arteries.
Topics: Animals; Arginine; Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Guinea | 1995 |
Expression of two alpha 2-adrenergic receptor subtypes in human placenta: evidence from direct binding studies.
Topics: Adult; Binding, Competitive; Dibenzazepines; Female; Humans; Imidazoles; Indoles; Isoindoles; Placen | 1994 |
Ontogeny of positive inotropic responses to sympathomimetic agents and of myocardial adrenoceptors in rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-1 Receptor Agonists | 1994 |
Adrenergic regulation of prostaglandin biosynthesis in cultured rabbit gastric epithelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Cells, Cultured; Dinoprostone; Epinephrine; | 1994 |
Evidence for the presence of noradrenergic neurons and their inhibitory action on luteinizing hormone-releasing hormone release in cultured fetal rat hypothalamic cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Cells, Cultu | 1993 |
[Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases].
Topics: Adult; Delayed-Action Preparations; Drug Monitoring; Female; Fetal Blood; Humans; Hypertension; Mate | 1993 |
Alpha-adrenergic receptors in human myometrium: changes during pregnancy.
Topics: Analysis of Variance; Female; Humans; Kinetics; Myometrium; Prazosin; Pregnancy; Pregnancy Trimester | 1993 |
Cocaine acutely increases rat myometrial contractile activity by mechanisms other than potentiation of adrenergic pathways.
Topics: Animals; Catecholamines; Cocaine; Female; In Vitro Techniques; Myometrium; Prazosin; Pregnancy; Rats | 1993 |
High-affinity uptake of noradrenaline in postsynaptic neurones.
Topics: Animals; Cell Membrane; Cells, Cultured; Desipramine; Female; Gonadotropin-Releasing Hormone; Hypoth | 1993 |
Central stimulation of oxytocin release in the lactating rat: interaction of neuropeptide Y with alpha-1-adrenergic mechanisms.
Topics: Animals; Cell Membrane; Dose-Response Relationship, Drug; Female; Gastrointestinal Hormones; Hypotha | 1993 |
Stimulatory effect of norepinephrine on progesterone production by human first trimester placenta explants in vitro.
Topics: Atenolol; Clonidine; Culture Media, Serum-Free; Cyclic AMP; Female; Gadolinium; Gonadotropin-Releasi | 1993 |
Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Facial Bones; Female; Fetal Death; Fetus; Huma | 1995 |
Effects of long-term high-altitude hypoxemia on alpha 1-adrenergic receptors in the ovine uterine artery.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Female; Hypoxia; Muscle Contraction; Norepinephrine | 1996 |
Neurotransmitter-mediated regulation of brain aromatase: protein kinase C- and G-dependent induction.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Re | 1996 |
High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries.
Topics: Acclimatization; Adrenergic alpha-Antagonists; Aging; Altitude; Animals; Cerebral Arteries; Female; | 1997 |
Heterogeneity and complexity of alpha 1-adrenoceptors in the ovine uterine artery and umbilical vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Binding, Competitive; Ca | 1997 |
Pheochromocytoma during pregnancy: case report.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Female; Humans; Hypertension; Pheochromocytoma; Prazo | 1997 |
Pheochromocytoma in pregnancy manifesting hypertensive crisis induced by metoclopramide.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adult; Antiemetics; Female; Humans; Hypertens | 1997 |
Characterization of alpha2-adrenoceptor subtypes in pregnant human myometrium.
Topics: Adrenergic alpha-Agonists; Binding, Competitive; Cell Membrane; Chlorpromazine; Female; Humans; Myom | 1998 |
Cocaine augments contractility of the pregnant human uterus by both adrenergic and nonadrenergic mechanisms.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Cocaine; Female; Humans; In Vitro Technique | 1998 |
Effect of chronic hypoxia on adrenoceptor responses of ovine foetal umbilical vessels.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relati | 1998 |
Correlation between alpha1/beta-adrenoceptor ratio and spontaneous uterine motor activity in the post-partum rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Dose-Response Relationship, Drug; F | 1998 |
Studies on the spasmolytic and uterine relaxant actions of n -ethyl and n -benzyl-1,2-diphenyl ethanolamines: elucidation of the mechanisms of action.
Topics: Adrenergic alpha-Antagonists; Animals; Blinking; Calcium Chloride; Dinoprostone; Dose-Response Relat | 1999 |
Gestational and ovarian sex steroid antinociception: relevance of uterine afferent and spinal alpha(2)-noradrenergic activity.
Topics: Adrenergic beta-Antagonists; Afferent Pathways; Analgesia; Animals; Estradiol; Female; Models, Neuro | 1999 |
Receptors and neurotransmitters involved in the dual modulation of prolactin release by the serotoninergic system in pregnant and lactating rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergi | 1999 |
Expectant management of early onset, severe pre-eclampsia: maternal outcome.
Topics: Adolescent; Adult; Antihypertensive Agents; Calcium Channel Blockers; Dihydralazine; Female; Fetal D | 2000 |
Expectant management of early onset, severe pre-eclampsia: perinatal outcome.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Female; Fetal Monitoring; Humans; Infant Mortalit | 2000 |
The role of prazosin in the management of hypertension.
Topics: Adolescent; Adrenergic beta-Antagonists; Anesthesia, General; Child; Coronary Disease; Diuretics; Dr | 1977 |
Prazosin alone and combined with a thiazide diuretic in the treatment of hypertension.
Topics: Adult; Aged; Cyclopenthiazide; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertension; M | 1977 |
Effects of estrogen pretreatment of the spare alpha 1-adrenoceptors and the slow and fast components of the contractile response of the isolated female rat aorta.
Topics: Animals; Aorta, Thoracic; Clonidine; Estrogens; Female; Muscle Contraction; Muscle, Smooth, Vascular | 1992 |
Antagonism of cocaine-induced fetal anomalies by prazosin and diltiazem in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cocaine; Diltiazem; Dose-Response Relationship, D | 1992 |
Alpha-1 adrenergic receptor: binding and phosphoinositide breakdown in human myometrium.
Topics: Binding, Competitive; Female; Humans; Kinetics; Myometrium; Norepinephrine; Phosphatidylinositols; P | 1991 |
Effects of Ca2+ antagonists nifedipine and diltiazem on isolated human chorionic arteries and veins.
Topics: Arteries; Calcium; Calcium Radioisotopes; Diltiazem; Female; Humans; In Vitro Techniques; Ketanserin | 1990 |
Influence of steroid hormone treatments or pregnancy on [3H]prazosin and [3H]rauwolscine binding to myometrial alpha-adrenoceptors in the ewe.
Topics: Adrenergic alpha-Antagonists; Animals; Estradiol; Female; Flurogestone Acetate; Gonadal Steroid Horm | 1990 |
Selective distribution of alpha-1 and beta adrenoceptors in pregnant rat uterus visualized by autoradiography.
Topics: Animals; Autoradiography; Female; Iodocyanopindolol; Pindolol; Prazosin; Pregnancy; Pregnancy, Anima | 1991 |
Effects of antiprogestogen (RU-486) treatment on myometrial and cervical alpha and beta-adrenoceptors in pregnant rabbits.
Topics: Animals; Cervix Uteri; Dihydroalprenolol; Female; Mifepristone; Myometrium; Prazosin; Pregnancy; Rab | 1990 |
Characterization of alpha-adrenoceptors in the late pregnant ovine uterine artery.
Topics: Adrenergic alpha-Agonists; Animals; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, | 1990 |
Effects of vasodilators on isolated human uteroplacental arteries.
Topics: Angiotensin II; Arteries; Chorionic Villi; Dinoprost; Female; Humans; Hydralazine; Labetalol; Nitren | 1991 |
Alpha 1-adrenergic receptors in pulmonary and systemic vascular smooth muscle. Alterations with development and pregnancy.
Topics: Age Factors; Analysis of Variance; Animals; Aorta, Thoracic; Binding Sites; Female; Fetus; In Vitro | 1990 |
Adrenergic receptors in human fetal liver membranes.
Topics: Adult; Cell Membrane; Dihydroalprenolol; Female; Fetus; Humans; Liver; Prazosin; Pregnancy; Radiolig | 1990 |
Myometrial alpha 1-adrenoceptors in pregnant guinea pig: their distribution and increased number.
Topics: Animals; Colforsin; Female; Guinea Pigs; Kinetics; Myometrium; Organ Specificity; Prazosin; Pregnanc | 1989 |
Autoradiographic visualization of alpha 1-adrenergic receptors in cervix of early pregnant rat.
Topics: Animals; Autoradiography; Cervix Uteri; Female; Myometrium; Prazosin; Pregnancy; Rats; Receptors, Ad | 1989 |
Changes in electrical activity of myometrium during intrauterine distribution of rat blastocysts and after prazosin administration.
Topics: Animals; Blastocyst; Electrophysiology; Estradiol; Female; Myometrium; Prazosin; Pregnancy; Pregnanc | 1989 |
Rat myometrial adrenergic receptors in late pregnancy.
Topics: 5'-Nucleotidase; Animals; Female; Isoproterenol; Myometrium; Nucleotidases; Prazosin; Pregnancy; Pre | 1987 |
Effect of pregnancy and sex steroids on alpha 1-adrenoceptor mechanisms in the guinea-pig uterine vascular bed.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Female; Gonadal Steroid Hormones; Guinea Pigs; I | 1988 |
[State of the fetoplacental system in late pregnancy toxicoses as affected by alpha 1-adrenoblocker therapy].
Topics: Adrenergic alpha-Antagonists; Adult; Female; Humans; Placental Function Tests; Prazosin; Pre-Eclamps | 1985 |
[Hypertension in pregnancy: proposed monitoring and therapy].
Topics: Adrenergic beta-Antagonists; Captopril; Diuretics; Female; Follow-Up Studies; Humans; Hydralazine; H | 1985 |
Metastatic pheochromocytoma in pregnancy and fetal biophysical assessment after maternal administration of alpha-adrenergic, beta-adrenergic, and dopamine antagonists.
Topics: Adult; alpha-Methyltyrosine; Catecholamines; Drug Therapy, Combination; Female; Fetal Heart; Fetal M | 1986 |
Perinatal exposure to cannabinoids alters neurochemical development in rat brain.
Topics: Aging; Animals; Brain; Brain Chemistry; Cannabinoids; Catecholamines; Corpus Striatum; Dronabinol; F | 1988 |
[Effect of alpha adrenoblockaders on the mother-placenta-fetus system in late pregnancy toxemia].
Topics: Adult; Female; Hemodynamics; Humans; Maternal-Fetal Exchange; Placenta; Prazosin; Pre-Eclampsia; Pre | 1986 |
Comparison of postnatal changes in alpha 1-adrenoceptor binding and adrenergic stimulation of phosphoinositide hydrolysis in rat cerebral cortex.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Female; Guanine Nucleotides; Hydrolysis; In Vitro Techni | 1985 |
Human myometrial adrenergic receptors during pregnancy: identification of the alpha-adrenergic receptor by [3H] dihydroergocryptine binding.
Topics: Dihydroergotoxine; Epinephrine; Female; Humans; Isoproterenol; Myometrium; Norepinephrine; Phentolam | 1985 |
Characterization of alpha-adrenoceptors in myometrium of preparturient rats.
Topics: Animals; Binding, Competitive; Dihydroergotoxine; Female; In Vitro Techniques; Kinetics; Membranes; | 1985 |
Effects of female hormones on the muscarinic and alpha 1-adrenergic receptors of the nasal mucosa. An experimental study in guinea pigs.
Topics: Animals; Estradiol; Female; Guinea Pigs; Male; Nasal Mucosa; Prazosin; Pregnancy; Pregnancy, Animal; | 1986 |
Pre- and neonatal exposure of the Dahl rat to NaCl: development and regional distribution of myocardial alpha 1-adrenergic and cholinergic receptor sites.
Topics: Animals; Animals, Newborn; Blood Pressure; Body Weight; Cell Membrane; Female; Heart; Heart Atria; H | 1986 |
Evidence for a noradrenergic transmission in the control of parturition in the rat.
Topics: Animals; Electromyography; Female; Hydroxydopamines; Labor, Obstetric; Norepinephrine; Oxidopamine; | 1986 |
Comparative effects of 6-hydroxydopamine and alpha-adrenoceptor antagonists on intrauterine migration and spacing of blastocysts in the rat.
Topics: Animals; Blastocyst; Embryo Implantation; Female; Hydroxydopamines; Myometrium; Norepinephrine; Oxid | 1987 |
Effect of alpha-adrenergic blocking agents on uterine activity in the ewe at the end of gestation.
Topics: Animals; Electromyography; Female; Labor, Obstetric; Myometrium; Prazosin; Pregnancy; Pregnancy, Ani | 1988 |
Effects of prazosin and indomethacin on the alpha-adrenergic stimulation of rabbit myometrium.
Topics: Animals; Dinoprost; Female; In Vitro Techniques; Indomethacin; Norepinephrine; Prazosin; Pregnancy; | 1988 |
Acetazolamide teratogenesis in Wistar rats: potentiation and antagonism by adrenergic agents.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Female; Limb Deformities, Congenital; Phenoxybe | 1986 |
Diagnosis and management of malignant hypertension.
Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Hypertension, Malignant; Kidney Function Tests | 1985 |
Bilateral phaeochromocytomas in pregnancy: anaesthetic management of combined caesarean section and tumour removal.
Topics: Adrenal Gland Neoplasms; Adult; Anesthesia, General; Cesarean Section; Female; Humans; Infant, Newbo | 1985 |