prazosin has been researched along with Obesity in 23 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to examine short-term effects of cilazapril and prazosin therapy on insulin sensitivity assessed by a 15' test of insulin tolerance of obese hypertensive persons." | 7.69 | [The effect of cilazapril and prazosin on insulin sensitivity in patients with essential hypertension]. ( Cirić, J; Nesović, M; Tasić, N; Trbojević, B; Zarković, M, 1995) |
| "A 51-year-old patient with COPD, obesity, and pulmonary hypertension underwent long-term prazosin therapy after a successful hemodynamic response to 1 mg of oral prazosin." | 7.68 | Long-term prazosin therapy for COPD pulmonary hypertension. ( Lewczuk, J; Piszko, P; Sobkowicz-Woźniak, B; Spikowski, J; Wrabec, K, 1992) |
| "The aim of this study was to determine whether insulin sensitivity measured by the euglycaemic insulin clamp technique is lower in patients with primary hypertension than in matched healthy control subjects, and whether this sensitivity was affected after 12 weeks of antihypertensive treatment with the alpha 1-adrenoceptor blocking drug prazosin." | 7.67 | Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension. ( Berne, C; Lithell, H; Pollare, T; Selinus, I, 1988) |
| "Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin." | 3.75 | Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. ( Belin de Chantemèle, EJ; Fulton, DJ; Marrero, MB; Mintz, J; Muta, K; Stepp, DW; Tremblay, ML, 2009) |
| " The objective of this study was to examine short-term effects of cilazapril and prazosin therapy on insulin sensitivity assessed by a 15' test of insulin tolerance of obese hypertensive persons." | 3.69 | [The effect of cilazapril and prazosin on insulin sensitivity in patients with essential hypertension]. ( Cirić, J; Nesović, M; Tasić, N; Trbojević, B; Zarković, M, 1995) |
| "A 51-year-old patient with COPD, obesity, and pulmonary hypertension underwent long-term prazosin therapy after a successful hemodynamic response to 1 mg of oral prazosin." | 3.68 | Long-term prazosin therapy for COPD pulmonary hypertension. ( Lewczuk, J; Piszko, P; Sobkowicz-Woźniak, B; Spikowski, J; Wrabec, K, 1992) |
| "The aim of this study was to determine whether insulin sensitivity measured by the euglycaemic insulin clamp technique is lower in patients with primary hypertension than in matched healthy control subjects, and whether this sensitivity was affected after 12 weeks of antihypertensive treatment with the alpha 1-adrenoceptor blocking drug prazosin." | 3.67 | Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension. ( Berne, C; Lithell, H; Pollare, T; Selinus, I, 1988) |
| "Tesofensine is a novel monoamine reuptake inhibitor that inhibits both norepinephrine, 5-HT, and dopamine (DA) reuptake function." | 1.36 | Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. ( Axel, AM; Hansen, HH; Mikkelsen, JD, 2010) |
| "Only clonidine treatment totally prevented the development of insulin resistance, and high-dose aspirin, known to prevent insulin resistance by inhibition of the activity of IkappaB kinase-beta, decreased the degree of insulin resistance by almost 70%." | 1.32 | Hypertension and insulin resistance are not directly related in obese dogs. ( Gokee, A; Rocchini, AP; Yang, JQ, 2004) |
| "LZR." | 1.32 | Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats. ( Frisbee, JC, 2004) |
| "Obesity is a circumstance characterized in the dog fat cell by a modification of the balance between alpha-2 and beta receptors." | 1.26 | Alpha-2 adrenergic antilipolytic effect in dog fat cells: incidence of obesity and adipose tissue localization. ( Berlan, M; Carpene, C; Dang-Tran, L; Lafontan, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (26.09) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belin de Chantemèle, EJ | 1 |
| Muta, K | 1 |
| Mintz, J | 1 |
| Tremblay, ML | 1 |
| Marrero, MB | 1 |
| Fulton, DJ | 1 |
| Stepp, DW | 1 |
| Axel, AM | 1 |
| Mikkelsen, JD | 1 |
| Hansen, HH | 1 |
| Janhunen, SK | 1 |
| van der Zwaal, EM | 1 |
| la Fleur, SE | 1 |
| Adan, RA | 1 |
| Rocchini, AP | 1 |
| Yang, JQ | 1 |
| Gokee, A | 1 |
| Frisbee, JC | 1 |
| Levin, BE | 4 |
| Hamm, MW | 1 |
| Patten, GS | 1 |
| Rattigan, S | 1 |
| Filsell, OH | 1 |
| Clark, MG | 1 |
| Kather, H | 1 |
| Simon, B | 1 |
| Berlan, M | 1 |
| Carpene, C | 1 |
| Lafontan, M | 1 |
| Dang-Tran, L | 1 |
| Planas, B | 2 |
| Routh, VH | 1 |
| Hamilton, J | 1 |
| Stern, JS | 1 |
| Horwitz, BA | 1 |
| Cirić, J | 1 |
| Zarković, M | 1 |
| Trbojević, B | 1 |
| Tasić, N | 1 |
| Nesović, M | 1 |
| Alonso-Galicia, M | 1 |
| Brands, MW | 1 |
| Zappe, DH | 1 |
| Hall, JE | 1 |
| Antic, V | 1 |
| Kiener-Belforti, F | 1 |
| Tempini, A | 1 |
| Van Vliet, BN | 1 |
| Montani, JP | 1 |
| Pelat, M | 1 |
| Verwaerde, P | 1 |
| Tran, MA | 1 |
| Montastruc, JL | 1 |
| Senard, JM | 1 |
| Chan, CB | 1 |
| MacPhail, RM | 1 |
| Lachaal, M | 1 |
| Jung, CY | 1 |
| Lewczuk, J | 1 |
| Sobkowicz-Woźniak, B | 1 |
| Piszko, P | 1 |
| Spikowski, J | 1 |
| Wrabec, K | 1 |
| Jhanwar-Uniyal, M | 1 |
| Awad, IR | 1 |
| Gearhart, GM | 1 |
| Finkelstein, JA | 1 |
| Leibowitz, SF | 1 |
| Auclair, MC | 1 |
| Vernimmen, C | 1 |
| Lavau, M | 1 |
| Lechat, P | 1 |
| Raasmaja, A | 1 |
| York, DA | 1 |
| Pollare, T | 1 |
| Lithell, H | 1 |
| Selinus, I | 1 |
| Berne, C | 1 |
1 review available for prazosin and Obesity
| Article | Year |
|---|---|
Insulin resistance and hypertension.
Topics: Adipose Tissue; Animals; Captopril; Catecholamines; Disease Models, Animal; Fructose; Glucose Tolera | 1992 |
22 other studies available for prazosin and Obesity
| Article | Year |
|---|---|
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood Pressure; Hypertension; Leptin; Male; Mice; Mice | 2009 |
Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Benzazepines; Body Weight; Bridged Bicy | 2010 |
Inverse agonism at α2A adrenoceptors augments the hypophagic effect of sibutramine in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Cyclobutanes | 2011 |
Hypertension and insulin resistance are not directly related in obese dogs.
Topics: Adrenergic beta-Antagonists; Animals; Aspirin; Atenolol; Blood Glucose; Clonidine; Diet, Sodium-Rest | 2004 |
Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats.
Topics: Adrenergic alpha-Agonists; Animals; Arterioles; Clonidine; Male; Metabolic Syndrome; Muscle, Skeleta | 2004 |
Plasticity of brain alpha-adrenoceptors during the development of diet-induced obesity in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Fatty Acids; Mal | 1994 |
Insensitivity of cardiac phosphofructokinase to adrenergic activation in Zucker rats. A post-receptor defect.
Topics: Animals; Calcium; Cell Membrane; Enzyme Activation; Epinephrine; Female; Heart; In Vitro Techniques; | 1984 |
[Weight loss with alpha-receptor blockers?].
Topics: Humans; Obesity; Phentolamine; Prazosin; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Alpha-2 adrenergic antilipolytic effect in dog fat cells: incidence of obesity and adipose tissue localization.
Topics: Adipose Tissue; Animals; Clonidine; Dogs; Epinephrine; Isoproterenol; Lipolysis; Obesity; Prazosin; | 1982 |
Defective glucoregulation of brain alpha 2-adrenoceptors in obesity-prone rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Glucose; Brain; Clonidine; Diet; Disease Susceptibility; M | 1993 |
Altered alpha 1-adrenoceptor binding in intact and adrenalectomized obese Zucker rats (fa/fa).
Topics: Adipose Tissue; Adrenalectomy; Animals; Autoradiography; Body Weight; Brain Chemistry; Genotype; Mal | 1993 |
[The effect of cilazapril and prazosin on insulin sensitivity in patients with essential hypertension].
Topics: Angiotensin-Converting Enzyme Inhibitors; Cilazapril; Female; Glucose Tolerance Test; Humans; Hypert | 1995 |
Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; | 1996 |
Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Blood Pressure D | 2000 |
Alpha2 -adrenoceptor function in arterial hypertension associated with obesity in dogs fed a high-fat diet.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood | 2002 |
Functional characterization of alpha-adrenoceptors on pancreatic islets of fa/fa Zucker rats.
Topics: Animals; Cells, Cultured; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epinep | 1992 |
Long-term prazosin therapy for COPD pulmonary hypertension.
Topics: Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Male; Middle Aged; Obesity; Prazosin; R | 1992 |
Higher alpha-noradrenergic receptors in paraventricular nucleus of obese Zucker rats: decline after food deprivation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Food Deprivation; Norepinephrine; Obesity; Pa | 1991 |
Obesity-prone and -resistant rats differ in their brain [3H]paraminoclonidine binding.
Topics: Animals; Brain; Clonidine; Male; Obesity; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergi | 1990 |
Dependence on extracellular potassium of the positive inotropic response to St 587, a selective alpha-1 adrenoceptor agonist, in Zucker rat heart ventricle.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Cell Membrane; Clonidine; Heart Ventricles; M | 1989 |
Alpha 1- and beta-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats. Effects of cold-acclimation, sucrose feeding and adrenalectomy.
Topics: Adipose Tissue, Brown; Adrenalectomy; Adrenergic beta-Antagonists; Animals; Binding Sites; Cell Memb | 1988 |
Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension.
Topics: Blood Glucose; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin; Insulin Infusion Syste | 1988 |