prazosin has been researched along with Myocardial Ischemia in 26 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The severity of arrhythmias (arrhythmia score, AS) was also markedly attenuated by both interventions (IPC: AS 1." | 1.31 | Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels. ( Pancza, D; Ravingerová, T; Styk, J; Ziegelhoffer, A, 2002) |
| "Prazosin was shown to have a *OH scavenging effect." | 1.30 | Prazosin attenuates hydroxyl radical generation in the rat myocardium. ( Obata, T; Yamanaka, Y, 1999) |
| "Tyramine pretreatment resulted in a smaller infarct size than in untreated controls (AN/AR, 0." | 1.29 | Alpha-adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning. ( Bankwala, Z; Hale, SL; Kloner, RA, 1994) |
| "Pretreatment with prazosin did not abolish the decrease in coronary blood flow." | 1.29 | Cardiogenic shock induced by cocaine in swine with normal coronary arteries. ( Baim, DS; Carrozza, JP; Gladstone, S; Gordon, PC; Kuntz, RE; Miao, L; Morgan, JP; Núñez, BD; Ross, JN, 1994) |
| "Prazosin and yohimbine were found to produce a significant increase in plasma norepinephrine levels in contrast to bunazosin, which had no significant effect." | 1.29 | Effects of alpha-adrenergic blockade on regional myocardial function in canine ischemic myocardium during beta-adrenergic blockade. ( Kono, M; Morita, S; Rubsamen, R, 1995) |
| "Pretreatment with prazosin abolished NE-induced cardioprotection while propranolol pretreatment had no effect." | 1.29 | Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoceptors. ( Ao, L; Banerjee, A; Brown, JM; Harken, AH; Meng, X, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (69.23) | 18.2507 |
| 2000's | 7 (26.92) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, L | 1 |
| Chen, L | 1 |
| Lu, ZZ | 1 |
| Gao, H | 1 |
| Wu, L | 1 |
| Chen, YX | 1 |
| Zhang, CM | 1 |
| Jiang, YK | 1 |
| Jing, Q | 1 |
| Zhang, YY | 1 |
| Yang, HT | 1 |
| Ravingerová, T | 1 |
| Pancza, D | 1 |
| Ziegelhoffer, A | 1 |
| Styk, J | 1 |
| Billman, GE | 1 |
| Node, K | 2 |
| Kitakaze, M | 3 |
| Kosaka, H | 1 |
| Komamura, K | 1 |
| Minamino, T | 3 |
| Tada, M | 1 |
| Inoue, M | 3 |
| Hori, M | 3 |
| Kamada, T | 1 |
| Morioka, T | 2 |
| Shinozaki, Y | 2 |
| Chujo, M | 2 |
| Mori, H | 2 |
| Takeda, H | 1 |
| Vanoli, E | 1 |
| Hull, SS | 1 |
| Foreman, RD | 1 |
| Ferrari, A | 1 |
| Schwartz, PJ | 1 |
| Moraru, II | 1 |
| Popescu, LM | 1 |
| Liu, X | 1 |
| Engelman, RM | 1 |
| Das, DK | 1 |
| Bankwala, Z | 1 |
| Hale, SL | 1 |
| Kloner, RA | 1 |
| Núñez, BD | 1 |
| Miao, L | 1 |
| Kuntz, RE | 1 |
| Ross, JN | 1 |
| Gladstone, S | 1 |
| Baim, DS | 1 |
| Gordon, PC | 1 |
| Morgan, JP | 1 |
| Carrozza, JP | 1 |
| Liusov, VA | 1 |
| Volov, NA | 1 |
| Dibirova, GO | 1 |
| Uteshev, DB | 1 |
| Takashima, S | 1 |
| Sato, H | 1 |
| Yamamoto, T | 1 |
| Nakatsuji, K | 1 |
| Hosoki, K | 1 |
| Karasawa, T | 1 |
| Kono, M | 1 |
| Morita, S | 1 |
| Rubsamen, R | 1 |
| Meng, X | 2 |
| Brown, JM | 1 |
| Ao, L | 1 |
| Banerjee, A | 2 |
| Harken, AH | 2 |
| Moolman, JA | 1 |
| Genade, S | 2 |
| Tromp, E | 1 |
| Lochner, A | 2 |
| Meldrum, DR | 1 |
| Cleveland, JC | 1 |
| Sheridan, BC | 1 |
| Joyeux, M | 1 |
| Godin-Ribuot, D | 1 |
| Patel, A | 1 |
| Demenge, P | 1 |
| Yellon, DM | 1 |
| Ribuot, C | 1 |
| Kurz, T | 1 |
| Schneider, I | 1 |
| Tölg, R | 1 |
| Richardt, G | 1 |
| Obata, T | 1 |
| Yamanaka, Y | 1 |
| Maczewski, M | 1 |
| Beresewicz, A | 1 |
| Sharma, A | 1 |
| Singh, M | 1 |
| Horio, T | 1 |
| Ito, S | 1 |
| Aoyama, M | 1 |
| Takeda, Y | 1 |
| Suzumura, H | 1 |
| Nakata, K | 1 |
| Yamada, Y | 1 |
| Suzuki, S | 1 |
| Fukutomi, T | 1 |
| Itoh, M | 1 |
| Loubani, M | 1 |
| Galiñanes, M | 1 |
| Kim, YH | 1 |
| Chun, YS | 1 |
| Park, JW | 1 |
| Kim, CH | 1 |
| Kim, MS | 1 |
| Abete, P | 1 |
| Testa, G | 1 |
| Ferrara, N | 1 |
| De Santis, D | 1 |
| Capaccio, P | 1 |
| Viati, L | 1 |
| Calabrese, C | 1 |
| Cacciatore, F | 1 |
| Longobardi, G | 1 |
| Condorelli, M | 1 |
| Napoli, C | 1 |
| Rengo, F | 1 |
| Mouton, R | 1 |
| Boschmans, SA | 1 |
| Perkins, MF | 1 |
26 other studies available for prazosin and Myocardial Ischemia
| Article | Year |
|---|---|
Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved postischemic myocardial performance via inhibiting MMP-2 activation.
Topics: Actinin; Adrenergic alpha-1 Receptor Antagonists; Animals; Doxycycline; Hypoxia; Male; Matrix Metall | 2014 |
Preconditioning modulates susceptibility to ischemia-induced arrhythmias in the rat heart: the role of alpha-adrenergic stimulation and K(ATP) channels.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Ant | 2002 |
Effect of alpha 1-adrenergic receptor antagonists on susceptibility to malignant arrhythmias: protection from ventricular fibrillation.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Disease Models, Animal; Dogs; Elect | 1994 |
Roles of alpha 1-adrenoceptor activity in the release of nitric oxide during ischemia of the canine heart.
Topics: Animals; Arginine; Dogs; Hemodynamics; Myocardial Ischemia; Myocardium; NG-Nitroarginine Methyl Este | 1995 |
Bidirectional effects of aminophylline on myocardial ischemia.
Topics: Adenosine; Aminophylline; Animals; Coronary Circulation; Dogs; Heart; Lactates; Lactic Acid; Myocard | 1995 |
Alpha 1-adrenergic blockade and sudden cardiac death.
Topics: Adrenergic alpha-Antagonists; Aminoquinolines; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac | 1994 |
Role of phospholipase A2, C, and D activities during myocardial ischemia and reperfusion.
Topics: Animals; Cytosol; Microsomes; Myocardial Ischemia; Myocardial Reperfusion; Phospholipase D; Phosphol | 1994 |
Alpha-adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning.
Topics: Animals; Blood Pressure; Coronary Circulation; Heart Rate; Male; Myocardial Infarction; Myocardial I | 1994 |
Cardiogenic shock induced by cocaine in swine with normal coronary arteries.
Topics: Animals; Blood Pressure; Cardiac Output; Cocaine; Coronary Circulation; Coronary Vessels; Female; Ma | 1994 |
[The prognosis of drug therapy efficacy in ventricular rhythm disorders by the level of intracellular Ca2+ in the lymphocytes of patients with ischemic heart disease].
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Calcium; Drug Evaluation; Drug Therapy, Combinat | 1993 |
Alpha 1-adrenoceptor activation mediates the infarct size-limiting effect of ischemic preconditioning through augmentation of 5'-nucleotidase activity.
Topics: 5'-Nucleotidase; Adaptation, Biological; Adenosine; Animals; Blood Pressure; Dogs; Endocardium; Esop | 1994 |
Preventive effect of a new calcium antagonist, monatepil, on drug-induced ischaemic electrocardiographic changes in rats.
Topics: Administration, Oral; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Vasospasm; Dibenzo | 1993 |
Effects of alpha-adrenergic blockade on regional myocardial function in canine ischemic myocardium during beta-adrenergic blockade.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Coronary Circulation; Dogs; Fema | 1995 |
Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Blotting, Northern; Gene Expression Regulation; Genes, fos; H | 1996 |
No evidence for mediation of ischemic preconditioning by alpha 1-adrenergic signal transduction pathway or protein kinase C in the isolated rat heart.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Alkaloids; Animals; Benzophenanthridines; Card | 1996 |
Hemorrhage induces acute cardioadaptation to ischemia-reperfusion by an alpha1-adrenoceptor-mediated, protein synthesis-independent mechanism.
Topics: Adaptation, Physiological; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Coronary Circulati | 1997 |
Infarct size-reducing effect of heat stress and alpha1 adrenoceptors in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Heat Stress Disorders; Heat-Shock Proteins; HSP72 | 1998 |
Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Analysis of | 1999 |
Prazosin attenuates hydroxyl radical generation in the rat myocardium.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Hydroxybenzoates; Hydroxyl Radical; Iro | 1999 |
The role of endothelin, protein kinase C and free radicals in the mechanism of the post-ischemic endothelial dysfunction in guinea-pig hearts.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Alkaloids; Angiotensin-Converting Enzyme Inhibitors; An | 2000 |
Possible mechanism of cardioprotective effect of angiotensin preconditioning in isolated rat heart.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiovascular Agents; Colchicine; Creatine Kinase; Female; | 2000 |
Effect of carvedilol on atrioventricular conduction in the ischemic heart.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bundle of His | 2001 |
alpha1-Adrenoceptors during simulated ischemia and reoxygenation of the human myocardium: effect of the dose and time of administration.
Topics: Adrenergic alpha-Antagonists; Creatine Kinase; Formazans; Humans; In Vitro Techniques; Ischemic Prec | 2001 |
Involvement of adrenergic pathways in activation of catalase by myocardial ischemia-reperfusion.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Fibers; Animals; Brain; Catalase | 2002 |
Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Aging; Animals; Blood Flow Velocity; Bod | 2002 |
The role of alpha 1-adrenergic stimulation in inositol phosphate metabolism during post-ischaemic reperfusion.
Topics: Animals; Chlorides; Chromatography, High Pressure Liquid; Heart Ventricles; Inositol 1,4,5-Trisphosp | 1992 |