prazosin has been researched along with Muscle Rigidity in 4 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This implied muscular rigidity was appreciably antagonized by prior intrathecal (10 microliters) administration of prazosin (5 or 10 nmol), but not equimolar dose of yohimbine." | 1.29 | Inhibition by intrathecal prazosin but not yohimbine of fentanyl-induced muscular rigidity in the rat. ( Chan, SH; Fu, MJ; Lee, TY; Lui, PW; Tsen, LY; Yeh, CP, 1995) |
| "This correlate of opiate-induced muscular rigidity was appreciably antagonized by a pretreatment with the specific alpha 1-adrenoceptor blocker, prazosin (250 micrograms/kg, i." | 1.28 | Involvement of coerulospinal noradrenergic pathway in fentanyl-induced muscular rigidity in rats. ( Chan, SH; Lee, TY; Lui, PW, 1990) |
| "Whereas muscular rigidity is a well-known phenomenon that is related to anesthesia induced by large doses of narcotic drugs, the precise underlying mechanism(s) remain to be fully elucidated." | 1.28 | Differential effects of prazosin and yohimbine on fentanyl-induced muscular rigidity in rats. ( Chan, SH; Lee, TY; Lui, PW; Pan, JT; Tsou, MY, 1989) |
| "Whereas muscular rigidity is a well-known side effect that is associated with high-dose fentanyl anesthesia, a paucity of information exists with regard to its underlying mechanism(s)." | 1.28 | Involvement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat. ( Chan, SH; Lee, TY; Lui, PW, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lui, PW | 4 |
| Tsen, LY | 1 |
| Fu, MJ | 1 |
| Yeh, CP | 1 |
| Lee, TY | 4 |
| Chan, SH | 4 |
| Tsou, MY | 1 |
| Pan, JT | 1 |
4 other studies available for prazosin and Muscle Rigidity
| Article | Year |
|---|---|
Inhibition by intrathecal prazosin but not yohimbine of fentanyl-induced muscular rigidity in the rat.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Electromyography; Fentanyl; Injections, I | 1995 |
Involvement of coerulospinal noradrenergic pathway in fentanyl-induced muscular rigidity in rats.
Topics: Adrenergic Fibers; Animals; Dose-Response Relationship, Drug; Fentanyl; Locus Coeruleus; Male; Micro | 1990 |
Differential effects of prazosin and yohimbine on fentanyl-induced muscular rigidity in rats.
Topics: Animals; Blood Pressure; Electromyography; Fentanyl; Heart Rate; Male; Muscle Rigidity; Muscles; Pra | 1989 |
Involvement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic Fibers; Anesthetics; Animals; Dose-Response Relationship, D | 1989 |