prazosin has been researched along with Injuries, Spinal Cord in 22 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prazosin was well tolerated and did not produce a significant lowering of resting blood pressure." | 2.67 | A study of the alpha-1 adrenoceptor blocker prazosin in the prophylactic management of autonomic dysreflexia in high spinal cord injury patients. ( Brown, DJ; Howes, LG; Krum, H; Louis, WJ, 1992) |
| "Clonidine treatment per se induced the expression of a single GMP, similar to a last reflexively evoked one, that was completely blocked by pre-treatment with prazosin (1 microg/animal) indicating that it was due to the alpha(1) properties of clonidine." | 1.32 | Yohimbine reverses the exhaustion of the coital reflex in spinal male rats. ( Carro-Juáreza, M; Rodríguez-Manzo, G, 2003) |
| "Such episodes (known as autonomic dysreflexia) are thought to result from the loss of descending baroreflex inhibition and/or plasticity within the spinal cord." | 1.32 | Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro. ( Brock, JA; McLachlan, EM; Yeoh, M, 2004) |
| "Terazosin was evaluated in 21 normotensive spinal cord injured patients with autonomic dysreflexia." | 1.29 | Prospective evaluation of terazosin for the treatment of autonomic dysreflexia. ( Chancellor, MB; Erhard, MJ; Hirsch, IH; Stass, WE, 1994) |
| " The dosage was gradually increased to 1-2 mg twice daily, depending upon patient tolerance and a minimum acceptable systolic blood pressure of 90 mm Hg." | 1.29 | Efficacy and safety of terazosin to improve voiding in spinal cord injury patients. ( Perkash, I, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, KH | 1 |
| Aulakh, KS | 1 |
| Liu, C | 1 |
| Phillips, AA | 1 |
| Elliott, SL | 1 |
| Zheng, MM | 1 |
| Krassioukov, AV | 1 |
| Rummery, NM | 1 |
| Tripovic, D | 1 |
| McLachlan, EM | 3 |
| Brock, JA | 3 |
| Rank, MM | 1 |
| Murray, KC | 1 |
| Stephens, MJ | 1 |
| D'Amico, J | 1 |
| Gorassini, MA | 1 |
| Bennett, DJ | 1 |
| Miyazato, M | 1 |
| Oshiro, T | 1 |
| Chancellor, MB | 4 |
| de Groat, WC | 1 |
| Yoshimura, N | 1 |
| Saito, S | 1 |
| Linsenmeyer, TA | 1 |
| Horton, J | 1 |
| Benevento, J | 1 |
| Carro-Juáreza, M | 1 |
| Rodríguez-Manzo, G | 1 |
| Yeoh, M | 2 |
| Okamura, K | 1 |
| Takamatsu, T | 1 |
| Koyanagi, T | 1 |
| Santajuliana, D | 1 |
| Zukowska-Grojec, Z | 1 |
| Osborn, JW | 1 |
| Rivas, DA | 2 |
| Huang, B | 1 |
| Salzman, SK | 1 |
| Erhard, MJ | 2 |
| Hirsch, IH | 1 |
| Stass, WE | 1 |
| Swierzewski, SJ | 1 |
| Gormley, EA | 1 |
| Belville, WD | 1 |
| Sweetser, PM | 1 |
| Wan, J | 1 |
| McGuire, EJ | 1 |
| Perkash, I | 1 |
| Kontani, H | 1 |
| Hayashi, K | 1 |
| Vaidyanathan, S | 2 |
| Soni, BM | 2 |
| Sett, P | 2 |
| Watt, JW | 1 |
| Oo, T | 1 |
| Bingley, J | 1 |
| Singh, G | 1 |
| Krishnan, KR | 1 |
| Liu, Z | 1 |
| Xu, S | 1 |
| Bennett, JK | 1 |
| Foote, J | 1 |
| El-Leithy, TR | 1 |
| Saleem, MD | 1 |
| Green, B | 1 |
| Archer, CL | 1 |
| Gray, M | 1 |
| Krum, H | 1 |
| Louis, WJ | 1 |
| Brown, DJ | 1 |
| Howes, LG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886] | 8 participants (Anticipated) | Interventional | 2021-06-08 | Recruiting | |||
| The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388] | 46 participants (Anticipated) | Interventional | 2020-02-01 | Not yet recruiting | |||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923] | 8 participants (Anticipated) | Interventional | 2021-12-31 | Recruiting | |||
| Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093] | 20 participants (Anticipated) | Interventional | 2021-11-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for prazosin and Injuries, Spinal Cord
| Article | Year |
|---|---|
[Evaluation and repair of bladder function after spinal cord injuries].
Topics: Adrenergic alpha-Antagonists; Animals; Electric Stimulation Therapy; Humans; Prazosin; Spinal Cord I | 1997 |
3 trials available for prazosin and Injuries, Spinal Cord
| Article | Year |
|---|---|
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Pathophysiology of autonomic dysreflexia: long-term treatment with terazosin in adult and paediatric spinal cord injury patients manifesting recurrent dysreflexic episodes.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Autonomic Nervous System Diseases; Child; Dose-Resp | 1998 |
A study of the alpha-1 adrenoceptor blocker prazosin in the prophylactic management of autonomic dysreflexia in high spinal cord injury patients.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Autonomic Nervous System Diseases; Blood Pressure; | 1992 |
18 other studies available for prazosin and Injuries, Spinal Cord
| Article | Year |
|---|---|
Retrospective evaluation of prazosin and diazepam after thoracolumbar hemilaminectomy in dogs.
Topics: Adjuvants, Anesthesia; Animals; Diazepam; Dog Diseases; Dogs; Female; Intervertebral Disc Displaceme | 2019 |
Sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Data Interpre | 2010 |
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Chromones; Clonidine; Excitatory Postsynaptic | 2011 |
An alpha1-adrenoceptor blocker terazosin improves urine storage function in the spinal cord in spinal cord injured rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Female; Phenylephrine; Prazosin; Rats; Rats, Sprag | 2013 |
Impact of alpha1-blockers in men with spinal cord injury and upper tract stasis.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Humans; Male; Prazosin | 2002 |
Yohimbine reverses the exhaustion of the coital reflex in spinal male rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Copulation; Ejaculation | 2003 |
Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Autonomic Dysreflexia; C | 2004 |
Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection.
Topics: Adenosine Triphosphate; Animals; Autonomic Dysreflexia; Electric Stimulation; Female; Mesenteric Art | 2006 |
[Management of chronic spinal cord injury patients with prazosin].
Topics: Adult; Chronic Disease; Female; Humans; Male; Middle Aged; Prazosin; Quinazolines; Spinal Cord Injur | 1983 |
Contribution of alpha- and beta- adrenoceptors and neuropeptide-Y to autonomic dysreflexia.
Topics: Animals; Autonomic Nervous System Diseases; Blood Pressure; Ganglionic Blockers; Heart Rate; Hexamet | 1995 |
Autonomic dysreflexia in a rat model spinal cord injury and the effect of pharmacologic agents.
Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System Diseases; Calcium Channel Blockers; | 1995 |
Prospective evaluation of terazosin for the treatment of autonomic dysreflexia.
Topics: Adrenergic alpha-Agonists; Adult; Autonomic Nervous System Diseases; Humans; Male; Middle Aged; Praz | 1994 |
Clinical effect of alpha-1 antagonism by terazosin on external and internal urinary sphincter function.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Follow-Up Studies; Humans; Male; Middle Aged; Penil | 1993 |
The effect of terazosin on bladder function in the spinal cord injured patient.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Drug Evaluation; Female; Humans; Male; Middle Aged; Prazo | 1994 |
Efficacy and safety of terazosin to improve voiding in spinal cord injury patients.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Aged; Dose-Response Relationship, Drug; H | 1995 |
Urinary bladder response to hypogastric nerve stimulation after bilateral resection of the pelvic nerve or spinal cord injury in rats.
Topics: Animals; Atropine; Chronic Disease; Electric Stimulation; Hexamethonium; Hypogastric Plexus; Nicotin | 1997 |
Prolonged penile erection association with terazosin in a cervical spinal cord injury patient.
Topics: Adrenergic alpha-Antagonists; Adult; Humans; Male; Neck; Prazosin; Priapism; Spinal Cord Injuries; T | 1998 |
Terazosin for vesicosphincter dyssynergia in spinal cord-injured male patients.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Ataxia; Humans; Male; Middle Aged; Prazosin; | 2000 |