prazosin has been researched along with Hypothyroidism in 15 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In hypothyroidism, 5'D-II is highly stimulated by the SNS and hypothyroxinemia." | 3.68 | Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold. ( Bianco, AC; Carvalho, SD; Kimura, ET; Silva, JE, 1991) |
| " The effect of artificial hypothyroidism (induced by feeding 6-propyl-2-thiouracil, PTU) and hyperthyroidism (induced by daily injections of triiodothyronine, T3) on myocardial adrenoceptor binding, catecholamines, some physiological responses, and their interdependence was examined." | 3.67 | Thyroid-dependent alterations of myocardial adrenoceptors and adrenoceptor-mediated responses in the rat. ( Gross, G; Lues, I, 1985) |
| "[3H]Prazosin binding was typical of an alpha 1-adrenergic receptor, and (-)epinephrine affinity for the [3H]prazosin-binding sites was not altered in the presence of 10(-5) M guanylyl-imidodiphosphate." | 1.27 | Normal ontogeny of alpha 1-adrenergic receptor in rat liver is thyroid hormone dependent. ( Noguchi, A, 1983) |
| "Prazosin (1 microM) was used to define nonspecific binding of [3H]DHE." | 1.27 | Alpha 1-adrenoreceptors and alpha 1-adrenoreceptor-mediated thyrotropin release in cultures of euthyroid and hypothyroid rat anterior pituitary cells. ( Dieguez, C; Foord, SM; Hall, R; Peters, JR; Scanlon, MF, 1985) |
| "Acquired hypothyroidism is also associated with a decreased density of alpha 1- and beta-adrenergic receptors in rat myocardium." | 1.26 | Ontogeny of alpha 1-adrenergic receptors in the rat myocardium: effects of hypothyroidism. ( Noguchi, A; Whitsett, JA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zaninovich, AA | 1 |
| Rebagliati, I | 1 |
| Raices, M | 1 |
| Ricci, C | 1 |
| Hagmuller, K | 1 |
| Yasuzawa-Amano, S | 1 |
| Toyoda, N | 1 |
| Maeda, A | 1 |
| Kosaki, A | 1 |
| Mori, Y | 1 |
| Iwasaka, T | 1 |
| Nishikawa, M | 1 |
| Medina, JH | 1 |
| Wolfman, C | 1 |
| Levi de Stein, M | 1 |
| Tumilasci, O | 1 |
| Houssay, AB | 1 |
| Chang, HY | 1 |
| Kunos, G | 2 |
| Preiksaitis, HG | 1 |
| Kan, WH | 1 |
| Noguchi, A | 2 |
| Whitsett, JA | 1 |
| Corvera, S | 1 |
| García-Sáinz, JA | 1 |
| Oguro, K | 1 |
| Ohguchi, S | 1 |
| Nakashima, M | 1 |
| Sandrini, M | 1 |
| Marrama, D | 1 |
| Vergoni, AV | 1 |
| Bertolini, A | 1 |
| Carvalho, SD | 1 |
| Kimura, ET | 1 |
| Bianco, AC | 1 |
| Silva, JE | 2 |
| Mills, I | 1 |
| Raasmaja, A | 1 |
| Moolten, N | 1 |
| Lemack, G | 1 |
| Larsen, PR | 1 |
| Dieguez, C | 1 |
| Foord, SM | 1 |
| Peters, JR | 1 |
| Hall, R | 1 |
| Scanlon, MF | 1 |
| Storm, H | 1 |
| van Hardeveld, C | 1 |
| Gross, G | 1 |
| Lues, I | 1 |
15 other studies available for prazosin and Hypothyroidism
| Article | Year |
|---|---|
Mitochondrial respiration in muscle and liver from cold-acclimated hypothyroid rats.
Topics: Adipose Tissue, Brown; Adrenergic Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Weight; C | 2003 |
Expression and regulation of type 2 iodothyronine deiodinase in rat aorta media.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aorta; Gene Expression Regulatio | 2004 |
Thyroid hormone regulation of adrenergic receptors and beta-adrenergic responsiveness in the rat submandibular gland.
Topics: Animals; Dihydroalprenolol; Hyperthyroidism; Hypothyroidism; Isoproterenol; Kinetics; Male; Prazosin | 1984 |
Short term effects of triiodothyronine on rat heart adrenoceptors.
Topics: Animals; Dihydroalprenolol; Hypothyroidism; Kinetics; Male; Myocardium; Prazosin; Rats; Receptors, A | 1981 |
Decreased alpha 1-adrenoceptor responsiveness and density in liver cells of thyroidectomized rats.
Topics: Animals; Binding, Competitive; Calcium; Enzyme Activation; Epinephrine; Hypothyroidism; In Vitro Tec | 1982 |
Ontogeny of alpha 1-adrenergic receptors in the rat myocardium: effects of hypothyroidism.
Topics: Animals; Animals, Newborn; Congenital Hypothyroidism; Dihydroalprenolol; Heart; Hypothyroidism; Kine | 1982 |
Normal ontogeny of alpha 1-adrenergic receptor in rat liver is thyroid hormone dependent.
Topics: Aging; Animals; Binding, Competitive; Cell Membrane; Female; Hypothyroidism; Kinetics; Liver; Male; | 1983 |
Hypothyroidism abolishes the glycogenolytic effect of vasopressin, angiotensin II and A23187 but not that of alpha 1-adrenergic amines in rat hepatocytes.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Calcimycin; Epinephrine; Female; Hypothyroidism; Kine | 1983 |
Induction of opposite response of hindlimb vasculature to adrenergic agents in hypothyroid rats.
Topics: Acetylcholine; Animals; Blood Pressure; Clonidine; Heart Rate; Hindlimb; Hypothyroidism; In Vitro Te | 1984 |
Effects of thyroid status on the characteristics of alpha 1-, alpha 2-, beta, imipramine and GABA receptors in the rat brain.
Topics: Animals; Brain; Dihydroalprenolol; Hyperthyroidism; Hypothyroidism; Imipramine; Kinetics; Male; Musc | 1991 |
Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Calorimetry; Cell Nucleus; Cold Tempera | 1991 |
Effect of thyroid status on catecholamine stimulation of thyroxine 5'-deiodinase in brown adipocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipose Tissue, Brown; Alprenolol; Animals; Catecholamines; | 1989 |
Alpha 1-adrenoreceptors and alpha 1-adrenoreceptor-mediated thyrotropin release in cultures of euthyroid and hypothyroid rat anterior pituitary cells.
Topics: Animals; Calcimycin; Cells, Cultured; Epinephrine; Hypothyroidism; Isoproterenol; Kinetics; Male; Pi | 1985 |
Effect of hypothyroidism on the cytosolic free Ca2+ concentration in rat hepatocytes during rest and following stimulation by noradrenaline or vasopressin.
Topics: Animals; Calcium; Cytosol; Hypothyroidism; Liver; Male; Norepinephrine; Oxygen Consumption; Prazosin | 1986 |
Thyroid-dependent alterations of myocardial adrenoceptors and adrenoceptor-mediated responses in the rat.
Topics: Animals; Cycloheximide; Decerebrate State; Dihydroalprenolol; Dose-Response Relationship, Drug; Elec | 1985 |