Page last updated: 2024-11-03

prazosin and Hypotension

prazosin has been researched along with Hypotension in 53 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"This study was designed to evaluate the safety and efficacy of the selective alpha 1-adrenoceptor blocker terazosin in the treatment of benign prostatic hyperplasia (BPH)."9.08A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of terazosin in the treatment of benign prostatic hyperplasia. ( Barkin, J; Beland, G; Boake, RC; Casey, RW; Elhilali, MM; Fradet, Y; Klotz, LH; Orovan, WL; Ramsey, EW; Schick, E; Trachtenberg, J, 1996)
"To examine the clinical usefulness of selective and non-selective alpha 1-adrenoceptor antagonists, we compared a selective (tamsulosin) and non-selective (terazosin) alpha 1-adrenoceptor antagonists in the treatment of Chinese patients with benign prostatic hyperplasia (BPH)."9.08Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group. ( Gu, FL; Guo, YL; Na, YJ, 1998)
"In this report, we assess the safety of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia."8.79Side effects of terazosin in the treatment of symptomatic benign prostatic hyperplasia. ( Lowe, FC; McKiernan, JM, 1997)
"The oral angiotensin-converting enzyme inhibitor captopril (CPT) produces beneficial hemodynamic and clinical responses in patients with chronic congestive heart failure (CHF)."7.66Captopril in congestive heart failure: improved left ventricular function with decreased metabolic cost. ( Chatterjee, K; Parmley, WW; Rouleau, JL, 1982)
"Prazosin's increase in popularity as a treatment for posttraumatic stress disorder makes it important for emergency physicians to be aware of how to manage potential toxic ingestion because of prazosin overdose."6.58Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature. ( Anderson, C; Gupta, R; Lim, RK; Lynch, T, 2018)
"choline can increase blood pressure in rats made hypotensive by acute chemical sympathectomy through the activation of central nicotinic receptors by presynaptic mechanisms."5.30Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy. ( Gürün, MS; Savci, V; Ulus, IH, 1997)
"This study was designed to evaluate the safety and efficacy of the selective alpha 1-adrenoceptor blocker terazosin in the treatment of benign prostatic hyperplasia (BPH)."5.08A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of terazosin in the treatment of benign prostatic hyperplasia. ( Barkin, J; Beland, G; Boake, RC; Casey, RW; Elhilali, MM; Fradet, Y; Klotz, LH; Orovan, WL; Ramsey, EW; Schick, E; Trachtenberg, J, 1996)
"To examine the clinical usefulness of selective and non-selective alpha 1-adrenoceptor antagonists, we compared a selective (tamsulosin) and non-selective (terazosin) alpha 1-adrenoceptor antagonists in the treatment of Chinese patients with benign prostatic hyperplasia (BPH)."5.08Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group. ( Gu, FL; Guo, YL; Na, YJ, 1998)
"In this report, we assess the safety of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia."4.79Side effects of terazosin in the treatment of symptomatic benign prostatic hyperplasia. ( Lowe, FC; McKiernan, JM, 1997)
" This study was designed to compare middle cerebral artery mean blood velocity responses to acute hypotension with and without alpha(1)-adrenoreceptor blockade (Prazosin) in young, healthy humans."3.74Autonomic neural control of the cerebral vasculature: acute hypotension. ( Brothers, RM; Eubank, WL; Ogoh, S; Raven, PB, 2008)
" Prazosin injection produced hypotension and tachycardia in both groups (C=-43+/-3 mm Hg/98+/-16 bpm; SW=-61+/-5 mm Hg/115+/-32 bpm)."3.73Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious rats. ( Basso, LS; Becker, LK; de Souza, HC; Garcia, MR; Lopes, OU; Martins-Pinge, MC; Neto, RV; Zoccal, DB, 2005)
" The reversal of hypotension by THA was greatly attenuated by administration of either prazosin, an alpha(1)-adrenoceptor antagonist (0."3.71Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine. ( Cavun, S; Gürün, MS; Savci, V; Ulus, IH, 2001)
"Treatment of benign prostatic hyperplasia (BPH) with nonselective alpha1 antagonists such as terazosin, doxazosin, and prazosin results in blood pressure reduction due to vasodilation."3.71Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study. ( Chao, J; Chrischilles, E; Gilden, D; Kreder, KJ; Rubenstein, L; Shah, H, 2001)
"The ectoparasiticide amitraz stimulates alpha 2-adrenoceptors to produce side-effects such as bradycardia and hypotension."3.69Amitraz depresses cardiovascular responses to bilateral carotid occlusion. ( Cullen, LK; Reynoldson, JA, 1996)
"The hypothesis that central alpha-1 adrenoceptors are inhibitory to the hypotension-induced secretion of vasopressin was tested by subjecting lambs that were instrumented for a long term to varying degrees of hypotension after intracerebroventricular injections of prazosin or placebo."3.68Central alpha-1-adrenergic control of vasopressin secretion in newborn lambs. ( Barnes, KD; Block, SM; Zoltoski, R, 1991)
"Our objectives were 1) to investigate the extent to which the pulmonary vascular response to increasing cardiac index after a period of hypotension and hypoperfusion (defined as reperfusion) measured in conscious dogs is altered during pentobarbital sodium anesthesia, and 2) to determine whether pentobarbital anesthesia modifies autonomic nervous system (ANS) regulation of the pulmonary circulation during reperfusion."3.67Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion. ( Chen, BB; Clougherty, PW; Fehr, DM; Goll, HM; Murray, PA; Nyhan, DP, 1988)
" Indomethacin treatment (5 mg/kg ia) of piglets following hemorrhage caused a significant decrease in blood flow to all brain regions within 20 min."3.67Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs. ( Armstead, WM; Beasley, DG; Busija, DW; Leffler, CW; Mirro, R, 1988)
"The oral angiotensin-converting enzyme inhibitor captopril (CPT) produces beneficial hemodynamic and clinical responses in patients with chronic congestive heart failure (CHF)."3.66Captopril in congestive heart failure: improved left ventricular function with decreased metabolic cost. ( Chatterjee, K; Parmley, WW; Rouleau, JL, 1982)
"Prazosin's increase in popularity as a treatment for posttraumatic stress disorder makes it important for emergency physicians to be aware of how to manage potential toxic ingestion because of prazosin overdose."2.58Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature. ( Anderson, C; Gupta, R; Lim, RK; Lynch, T, 2018)
" These compounds, when dosed of 1."1.42α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one. ( Bednarski, M; Dudek, M; Kulig, K; Lustyk, K; Malawska, B; Nowiński, L; Raźny, K; Sapa, J; Siwek, A; Starowicz, G; Zaręba, P, 2015)
"Anaphylactic shock is sometimes life-threatening, and it is accompanied by hepatic venoconstriction in animals, which, in part, accounts for anaphylactic hypotension."1.39Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats. ( Kurata, Y; Shibamoto, T; Tanida, M; Wang, M, 2013)
"Prazosin treatment prolonged the duration of NTG-induced MAP response by about 4-fold for all NTG doses examined (P < 0."1.32Prazosin potentiates the acute hypotensive effects of nitroglycerin but does not attenuate nitrate tolerance in normal conscious rats. ( Fung, HL; Wang, EQ, 2004)
"choline can increase blood pressure in rats made hypotensive by acute chemical sympathectomy through the activation of central nicotinic receptors by presynaptic mechanisms."1.30Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy. ( Gürün, MS; Savci, V; Ulus, IH, 1997)
"Arterial hypotension can cause cerebral ischemia when the autoregulation of the cerebral circulation is exhausted."1.30Cerebral vasoconstriction during sustained ventricular tachycardia induces an ischemic stress response of brain tissue in rats. ( Danos, P; Dettmers, C; Hagendorff, A; Heusch, G; Hümmelgen, M; Lüderitz, B; Martin, C; Vahlhaus, C, 1998)
"5 mm Hg per ng/ml when prazosin was combined with verapamil (p less than 0."1.28An additive or synergistic drug interaction: application of concentration-effect modeling. ( Elliott, HL; Meredith, PA, 1992)

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-199020 (37.74)18.7374
1990's15 (28.30)18.2507
2000's10 (18.87)29.6817
2010's8 (15.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zaręba, P1
Dudek, M1
Lustyk, K1
Siwek, A1
Starowicz, G1
Bednarski, M1
Nowiński, L1
Raźny, K1
Sapa, J1
Malawska, B1
Kulig, K1
Anderson, C1
Lynch, T1
Gupta, R1
Lim, RK1
Iwai, T1
Kaneko, M1
Sasaki-Hamada, S1
Oka, J1
Wang, M1
Tanida, M1
Shibamoto, T1
Kurata, Y1
Agrawal, R1
Mishra, SK1
Bhatia, E1
Mishra, A1
Chand, G1
Agarwal, G1
Agarwal, A1
Verma, AK1
Wahab, NA1
Zainudin, S1
AbAziz, A1
Kamaruddin, NA1
Ogoh, S2
Sørensen, H1
Hirasawa, A1
Sasaki, H1
Washio, T1
Hashimoto, T1
Bailey, DM1
Secher, NH1
Belayneh, M1
Korownyk, C1
Prakash, ES1
Mathis, KW1
Molina, PE1
Wang, EQ1
Fung, HL1
Valdivia, LF1
Centurión, D1
Arulmani, U1
Saxena, PR1
Villalón, CM1
Martins-Pinge, MC1
Becker, LK1
Garcia, MR1
Zoccal, DB1
Neto, RV1
Basso, LS1
de Souza, HC1
Lopes, OU1
Jochem, J1
Zwirska-Korczala, K1
Zabielski, R1
Kato, I1
Kuwahara, A1
Brothers, RM1
Eubank, WL1
Raven, PB1
Hamilton, TC1
Hunt, AA1
Poyser, RH1
Roquebert, J1
Demichel, P1
Malek, A1
Chatterjee, K1
Rouleau, JL1
Parmley, WW1
Jee, LD1
Opie, LH1
Rubin, PC1
Brunton, J1
Meredith, P1
Gerber, JG1
Nies, AS1
Olson, RD1
Glass, AR1
Ballou, R1
Baum, T1
Sabin, C1
Moran, RM1
Sugimoto, T1
Hosoki, K1
Karasawa, T1
Lydiatt, CA1
Fee, MP1
Hill, GE1
Elhilali, MM1
Ramsey, EW1
Barkin, J1
Casey, RW1
Boake, RC1
Beland, G1
Fradet, Y1
Trachtenberg, J1
Orovan, WL1
Schick, E1
Klotz, LH1
Reynoldson, JA1
Cullen, LK1
Dunbar, JC1
O'Leary, DS1
Wang, G1
Wright-Richey, J1
McKiernan, JM1
Lowe, FC1
Gürün, MS2
Savci, V2
Ulus, IH2
Hagendorff, A1
Dettmers, C1
Danos, P1
Hümmelgen, M1
Vahlhaus, C1
Martin, C1
Heusch, G1
Lüderitz, B1
Na, YJ1
Guo, YL1
Gu, FL1
Iversen, PL1
Cornish, KG1
Iversen, LJ1
Mata, JE1
Bylund, DB1
Cavun, S1
Chrischilles, E1
Rubenstein, L1
Chao, J1
Kreder, KJ1
Gilden, D1
Shah, H1
Takakura, K1
Taniguchi, T1
Muramatsu, I1
Takeuchi, K1
Fukuda, S1
Moulds, RJ1
Jauernig, RA1
Imhof, P1
Bendall, MJ1
Meredith, PA1
Elliott, HL1
Block, SM1
Barnes, KD1
Zoltoski, R1
Hasford, J2
Bussmann, WD2
Delius, W2
Koepcke, W1
Lehmann, K2
Weber, E2
Zhang, C1
Hsueh, W1
Köpcke, W1
Jeffries, WB1
Tam, LT1
Wang, Y1
Smyth, DD1
Pettinger, WA1
Feldman, T1
Carroll, JD1
Munkenbeck, F1
Alibali, P1
Feldman, M1
Coggins, DL1
Gray, KR1
Bump, T1
Chen, BB1
Nyhan, DP1
Goll, HM1
Clougherty, PW1
Fehr, DM1
Murray, PA1
Jordan, DA1
Breslow, MJ1
Kubos, KL1
Traystman, RJ1
Bond, RF2
Johnson, G2
Jones, CE1
Liang, IY1
Maulsby, MR1
Armstead, WM1
Leffler, CW1
Busija, DW1
Beasley, DG1
Mirro, R1
Lin, MS1
Hsieh, WJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise[NCT03722953]18 participants (Actual)Interventional2018-12-01Completed
The Effects of Systemic Alfuzosin and Tamsulosin Hydrochloride on Choroidal Thickness and Pupil Diameter Sizes in Cases With Benign Prostatic Hyperplasia[NCT03144596]Phase 463 participants (Actual)Interventional2015-10-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for prazosin and Hypotension

ArticleYear
Refractory Hypotension Caused by Prazosin Overdose Combined With Acetaminophen and Naproxen Toxicity: A Case Report and Review of the Literature.
    The Journal of emergency medicine, 2018, Volume: 55, Issue:6

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antihy

2018
Treatment of lower urinary tract symptoms in benign prostatic hypertrophy with α-blockers.
    Canadian family physician Medecin de famille canadien, 2016, Volume: 62, Issue:9

    Topics: Adrenergic alpha-Antagonists; Dizziness; Doxazosin; Humans; Hypotension; Lower Urinary Tract Symptom

2016
Side effects of terazosin in the treatment of symptomatic benign prostatic hyperplasia.
    Southern medical journal, 1997, Volume: 90, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Clinical Trials as Topic; Dizziness; Humans;

1997
[Treatment of cardiac failure with vasodilators (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, May-30, Volume: 67, Issue:22

    Topics: Cardiac Glycosides; Diuretics; Drug Therapy, Combination; Heart Failure; Hydralazine; Hypotension; I

1978

Trials

5 trials available for prazosin and Hypotension

ArticleYear
Prospective study to compare peri-operative hemodynamic alterations following preparation for pheochromocytoma surgery by phenoxybenzamine or prazosin.
    World journal of surgery, 2014, Volume: 38, Issue:3

    Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adult; Blood Pressure; Female; Heart Rate; He

2014
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of terazosin in the treatment of benign prostatic hyperplasia.
    Urology, 1996, Volume: 47, Issue:3

    Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Analysis of Variance; Canada; Double-Blind Me

1996
Clinical comparison of selective and non-selective alpha 1A-adrenoceptor antagonists for bladder outlet obstruction associated with benign prostatic hyperplasia: studies on tamsulosin and terazosin in Chinese patients. The Chinese Tamsulosin Study Group.
    Journal of medicine, 1998, Volume: 29, Issue:5-6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Aged; Dose-Response Relations

1998
First dose hypotension with enalapril and prazosin in congestive heart failure.
    International journal of cardiology, 1991, Volume: 31, Issue:3

    Topics: Aged; Drug Evaluation; Enalapril; Female; Follow-Up Studies; Heart Failure; Humans; Hypotension; Log

1991
Design and analysis of the HYPREN-trial: safety of enalapril and prazosin in the initial treatment phase of patients with congestive heart failure.
    Zeitschrift fur Kardiologie, 1991, Volume: 80 Suppl 2

    Topics: Aged; Enalapril; Female; Heart Failure; Hemodynamics; Humans; Hypotension; Male; Prazosin

1991

Other Studies

44 other studies available for prazosin and Hypotension

ArticleYear
α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one.
    Bioorganic & medicinal chemistry, 2015, May-01, Volume: 23, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Dose-Response Relationship, Drug; Hypotension; Mal

2015
Characterization of the hypotensive effects of glucagon-like peptide-2 in anesthetized rats.
    Neuroscience letters, 2013, Aug-29, Volume: 550

    Topics: Animals; Antihypertensive Agents; Arterial Pressure; Atropine; Glucagon-Like Peptide 2; Hypotension;

2013
Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Oct-15, Volume: 305, Issue:8

    Topics: Adrenergic alpha-1 Receptor Antagonists; Anaphylaxis; Animals; Hypertension, Portal; Hypotension; Li

2013
Utility of alpha-blockade in a hypotensive pheochromocytoma patient with myocardial infarction.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2015, Volume: 24, Issue:1

    Topics: Adrenal Gland Neoplasms; Adrenergic alpha-1 Receptor Antagonists; Adult; Echocardiography; Humans; H

2015
Dynamic cerebral autoregulation is unrelated to decrease in external carotid artery blood flow during acute hypotension in healthy young men.
    Experimental physiology, 2016, 08-01, Volume: 101, Issue:8

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Arterial Pressure; Carotid Artery, External; Carotid

2016
Effect of prazosin on dynamic cerebral autoregulation during acute hypotension in healthy human subjects.
    Stroke, 2008, Volume: 39, Issue:11

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebral Cortex; Cerebrovascular Circulation; Home

2008
Central acetylcholinesterase inhibition improves hemodynamic counterregulation to severe blood loss in alcohol-intoxicated rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:2

    Topics: Alcoholic Intoxication; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Bl

2009
Prazosin potentiates the acute hypotensive effects of nitroglycerin but does not attenuate nitrate tolerance in normal conscious rats.
    Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Drug Synergism; Drug Tolerance; Hypotension;

2004
5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:1

    Topics: Animals; Biphenyl Compounds; Blood Pressure; Carotid Artery, External; Dogs; Dose-Response Relations

2004
Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious rats.
    Autonomic neuroscience : basic & clinical, 2005, Oct-30, Volume: 122, Issue:1-2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Consciousness; Dose-Respons

2005
Cardiovascular effects of centrally acting orexin A in haemorrhage-shocked rats.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2006, Volume: 57 Suppl 11

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiovascular S

2006
Autonomic neural control of the cerebral vasculature: acute hypotension.
    Stroke, 2008, Volume: 39, Issue:7

    Topics: Administration, Oral; Adult; Autonomic Nervous System; Blood Pressure; Cerebrovascular Circulation;

2008
Involvement of central alpha 2-adrenoceptors in the mediation of clonidine-induced hypotension in the cat.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:11

    Topics: Animals; Blood Pressure; Cats; Clonidine; Female; Hypotension; Prazosin; Receptors, Adrenergic; Rece

1980
Effects of thymoxamine and its metabolites on clonidine-induced hypotension and bradycardia in rats.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 258, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypotension; Male; Moxisyly

1982
Captopril in congestive heart failure: improved left ventricular function with decreased metabolic cost.
    American heart journal, 1982, Volume: 104, Issue:5 Pt 2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Heart Failure; Heart Ventricles; Hemodynamics;

1982
Acute hypotensive response to nifedipine added to prazosin in treatment of hypertension.
    British medical journal (Clinical research ed.), 1983, Nov-19, Volume: 287, Issue:6404

    Topics: Adult; Drug Therapy, Combination; Humans; Hypertension; Hypotension; Male; Nifedipine; Prazosin; Qui

1983
Determination of the vasodilator UK33274 by high-performance liquid chromatography using fluorescence detection.
    Journal of chromatography, 1980, Nov-14, Volume: 221, Issue:1

    Topics: Chromatography, High Pressure Liquid; Doxazosin; Humans; Hypotension; Prazosin; Quinazolines; Vasodi

1980
Prazosin does not alter canine renin release in response to systemic hypotension or intrarenal isoprenaline and prostaglandin I2 infusion.
    British journal of pharmacology, 1980, Volume: 71, Issue:2

    Topics: Animals; Dogs; Epoprostenol; Hemodynamics; Hypotension; Infusions, Parenteral; Isoproterenol; Kidney

1980
Pheochromocytoma, prazosin, and hypotension.
    Annals of internal medicine, 1982, Volume: 97, Issue:3

    Topics: Adrenal Gland Neoplasms; Female; Humans; Hypotension; Middle Aged; Pheochromocytoma; Prazosin; Quina

1982
Comparison of hypotensive, orthostatic and sympathetic inhibitory actions of antihypertensive drugs in rats.
    Clinical and experimental hypertension, 1981, Volume: 3, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diazepam; Guanethidine; Heart Rate; Hyd

1981
Relative contribution of alpha 1-adrenoceptor blocking activity to the hypotensive effect of the novel calcium antagonist monatepil.
    Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:1

    Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Calc

1995
Severe hypotension during epidural anesthesia in a prazosin-treated patient.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:5

    Topics: Anesthesia, Epidural; Epinephrine; Humans; Hypotension; Male; Middle Aged; Phenylephrine; Prazosin;

1993
Amitraz depresses cardiovascular responses to bilateral carotid occlusion.
    Journal of veterinary pharmacology and therapeutics, 1996, Volume: 19, Issue:1

    Topics: Animals; Baroreflex; Blood Pressure; Bradycardia; Carotid Arteries; Carotid Stenosis; Dogs; Dose-Res

1996
Mechanisms mediating insulin-induced hypotension in rats. A role for nitric oxide and autonomic mediators.
    Acta diabetologica, 1996, Volume: 33, Issue:4

    Topics: Animals; Antihypertensive Agents; Atenolol; Atropine; Autonomic Nervous System; Blood Glucose; Blood

1996
Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy.
    Journal of autonomic pharmacology, 1997, Volume: 17, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Choline; Cholinergic Antagonists; Dose-Respon

1997
Cerebral vasoconstriction during sustained ventricular tachycardia induces an ischemic stress response of brain tissue in rats.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:10

    Topics: Adrenergic alpha-Antagonists; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Epinephri

1998
Bolus intravenous injection of phosphorothioate oligonucleotides causes hypotension by acting as alpha(1)-adrenergic receptor antagonists.
    Toxicology and applied pharmacology, 1999, Nov-01, Volume: 160, Issue:3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Cell Membrane; Cerebral Cortex; Heart Atria; Heart

1999
Reversal of Haemorrhagic Shock in Rats by Tetrahydroaminoacridine.
    Pharmacology, 2001, Volume: 62, Issue:1

    Topics: Adrenergic alpha-Antagonists; Anesthetics, Intravenous; Animals; Antidiuretic Hormone Receptor Antag

2001
Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study.
    Clinical therapeutics, 2001, Volume: 23, Issue:5

    Topics: Accidental Falls; Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Cohort Studies; Comor

2001
Modification of alpha1 -adrenoceptors by peroxynitrite as a possible mechanism of systemic hypotension in sepsis.
    Critical care medicine, 2002, Volume: 30, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Calcium; CHO Cells; Cricetinae; Hypotension; In Vitro

2002
Mechanism of prazosin collapse.
    Lancet (London, England), 1977, Jan-22, Volume: 1, Issue:8004

    Topics: Adrenergic alpha-Antagonists; Arteries; Dose-Response Relationship, Drug; Humans; Hypotension; In Vi

1977
Side effects of prazocin.
    British medical journal, 1976, Nov-06, Volume: 2, Issue:6044

    Topics: Blood Pressure; Humans; Hypotension; Prazosin; Quinazolines; Research Design

1976
An additive or synergistic drug interaction: application of concentration-effect modeling.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:6

    Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug The

1992
Central alpha-1-adrenergic control of vasopressin secretion in newborn lambs.
    Pediatric research, 1991, Volume: 30, Issue:1

    Topics: Animals; Animals, Newborn; Arginine Vasopressin; Blood Pressure; Dose-Response Relationship, Drug; H

1991
PAF-induced bowel necrosis. Effects of vasodilators.
    Digestive diseases and sciences, 1991, Volume: 36, Issue:5

    Topics: Alprostadil; Animals; Hydralazine; Hypotension; Indazoles; Intestinal Diseases; Leukopenia; Male; Me

1991
Prazosin-induced alterations in renal alpha-adrenergic receptor function.
    Hypertension (Dallas, Tex. : 1979), 1987, Volume: 9, Issue:6 Pt 2

    Topics: Adrenergic beta-Agonists; Animals; Cocaine; Electric Stimulation; Hypotension; In Vitro Techniques;

1987
Hemodynamic recovery during simulated ventricular tachycardia: role of adrenergic receptor activation.
    American heart journal, 1988, Volume: 115, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiac Pacing, Artificial; Dise

1988
Pentobarbital anesthesia modifies pulmonary vasoregulation after hypoperfusion.
    The American journal of physiology, 1988, Volume: 255, Issue:3 Pt 2

    Topics: Acetylcholine; Anesthesia, General; Animals; Autonomic Nervous System; Blood Pressure; Cardiac Outpu

1988
Adrenergic receptors of adrenal medullary vasculature.
    The American journal of physiology, 1989, Volume: 256, Issue:1 Pt 2

    Topics: Adrenal Medulla; Animals; Catecholamines; Dogs; Hemorrhage; Hypotension; Microspheres; Pindolol; Pra

1989
Alpha 1- and alpha 2-adrenoreceptor relationships in SHRs during hypotension.
    Circulatory shock, 1985, Volume: 17, Issue:2

    Topics: Adrenal Medulla; Animals; Blood Pressure; Hypotension; Male; Prazosin; Pressoreceptors; Propranolol;

1985
Cardiac and coronary effects of prazosin and phenoxybenzamine during coronary hypotension.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1

    Topics: Animals; Coronary Circulation; Dogs; Female; Heart; Hypotension; Male; Oxygen Consumption; Phenoxybe

1986
Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs.
    The American journal of physiology, 1988, Volume: 254, Issue:4 Pt 2

    Topics: Animals; Animals, Newborn; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Hemor

1988
Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.
    Drug intelligence & clinical pharmacy, 1987, Volume: 21, Issue:9

    Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Female; Humans; Hy

1987
Cardiovascular adrenoreceptor balance during hemorrhagic hypotension and shock.
    Circulatory shock, 1985, Volume: 16, Issue:2

    Topics: Animals; Cyclooxygenase Inhibitors; Hypotension; Male; Meclofenamic Acid; Prazosin; Rats; Rats, Inbr

1985