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prazosin and Hyperplasia

prazosin has been researched along with Hyperplasia in 4 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Research Excerpts

ExcerptRelevanceReference
"Prazosin-treated rabbits had significantly less luminal reduction at 1 week (0."5.28Role for prazosin in reducing the development of rabbit intimal hyperplasia after endothelial denudation. ( McDermott, EW; Mehigan, D; O'Higgins, NJ; O'Malley, MK, 1989)
" Standardized dose-response curves demonstrated that the injured tissue was increasingly sensitive over time to norepinephrine and that this was more marked at physiologic levels of norepinephrine."1.27Increased vascular contraction and sensitivity to norepinephrine after endothelial denudation is inhibited by prazosin. ( Cole, CW; Hagen, PO; McCann, RL; Mikat, EM; O'Malley, MK; Radic, ZS, 1986)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guh, JH1
Chueh, SC1
Ko, FN1
Teng, CM1
Norman, PE1
House, AK1
O'Malley, MK2
McDermott, EW1
Mehigan, D1
O'Higgins, NJ1
Hagen, PO1
Mikat, EM1
Cole, CW1
Radic, ZS1
McCann, RL1

Other Studies

4 other studies available for prazosin and Hyperplasia

ArticleYear
Characterization of alpha 1-adrenoceptor subtypes in tension response of human prostate to electrical field stimulation.
    British journal of pharmacology, 1995, Volume: 115, Issue:1

    Topics: Adrenergic Antagonists; Animals; Clonidine; Electric Stimulation; Humans; Hyperplasia; In Vitro Tech

1995
Influence of prazosin on experimental vein graft intimal thickening.
    The British journal of surgery, 1992, Volume: 79, Issue:3

    Topics: Anastomosis, Surgical; Animals; Blood Vessel Prosthesis; Hyperplasia; Iliac Artery; Male; Prazosin;

1992
Role for prazosin in reducing the development of rabbit intimal hyperplasia after endothelial denudation.
    The British journal of surgery, 1989, Volume: 76, Issue:9

    Topics: Animals; Aorta, Abdominal; Endothelium, Vascular; Hyperplasia; Muscle, Smooth, Vascular; Prazosin; R

1989
Increased vascular contraction and sensitivity to norepinephrine after endothelial denudation is inhibited by prazosin.
    Surgery, 1986, Volume: 99, Issue:1

    Topics: Animals; Aorta, Abdominal; Catheterization; Dose-Response Relationship, Drug; Endothelium; Hyperplas

1986