Page last updated: 2024-11-03

prazosin and Hemorrhage

prazosin has been researched along with Hemorrhage in 18 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Hemorrhage: Bleeding or escape of blood from a vessel.

Research Excerpts

ExcerptRelevanceReference
" The role of alpha(1)-adrenergic stimulation in myocardial TNF-alpha expression and depressed cardiac function after HS/R was assessed by treatment with the alpha(1)-adrenergic inhibitor, prazosin hydrochloride (1 mg/kg ip), for 1 h before the onset of hemorrhage."3.71Hemorrhage-induced alpha-adrenergic signaling results in myocardial TNF-alpha expression and contractile dysfunction. ( Klein, LV; Lindsay, TF; Marshall, JG; Nicholson, S; Rubin, BB; Shahani, R; Walker, PM, 2001)
"5 mg/kg) or Group 3, captopril (4 mg/kg), each followed by bleeding as in the group 1."3.69Insight into blood-pressure control in SHR via the response to acute hemorrhage: a spectral analysis approach. ( Akselrod, S; Cohen, S; Eliash, S; Oz, O, 1995)
"To determine the importance of alpha 1-adrenergic receptors in the endocrine responses of fetal lambs to hemorrhage, eight chronically instrumented fetal lambs were bled of 20% of their measured blood volume after pretreatment with prazosin (24."3.67Endocrine responses of fetal lambs to hemorrhage after alpha 1-adrenergic receptor blockade. ( Barnes, KD; Block, SM; Rawashdeh, N; Ray, D; Rose, JC, 1988)
" Indomethacin treatment (5 mg/kg ia) of piglets following hemorrhage caused a significant decrease in blood flow to all brain regions within 20 min."3.67Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs. ( Armstead, WM; Beasley, DG; Busija, DW; Leffler, CW; Mirro, R, 1988)
" Pretreatment with guanethidine did not affect basal output of HCO3- but markedly reduced the bleeding-induced response."3.67Bleeding-induced decrease in duodenal HCO3- secretion in the rat is mediated via alpha 2-adrenoceptors. ( Fändriks, L; Jönson, C, 1987)
"Hemorrhage was conducted over 5 min at the level of 0."1.29Effects of alpha-adrenergic activation on the shift of electrolytes and fluid after hemorrhage in rats. ( Nagashima, K, 1995)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19905 (27.78)18.7374
1990's10 (55.56)18.2507
2000's3 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, Y1
Liu, H1
Gaskari, SA1
Tyberg, JV1
Lee, SS1
Mathis, KW1
Molina, PE1
Nagashima, K1
Almog, Y1
Eliash, S3
Oz, O3
Akselrod, S3
Cohen, S2
Baujard, C1
Ponchon, P3
Elghozi, JL3
Meldrum, DR2
Cleveland, JC2
Meng, X1
Sheridan, BC2
Banerjee, A2
Harken, AH2
Rowland, RT1
Selzman, CH1
Shahani, R1
Klein, LV1
Marshall, JG1
Nicholson, S1
Rubin, BB1
Walker, PM1
Lindsay, TF1
Hasser, EM1
Schadt, JC1
Leffler, CW2
Busija, DW2
Share, L1
Crofton, JT1
Brooks, DP1
Beasley, DG2
Green, RS1
Mirro, R2
Block, SM1
Rose, JC1
Ray, D1
Rawashdeh, N1
Barnes, KD1
Jordan, DA1
Breslow, MJ1
Kubos, KL1
Traystman, RJ1
Armstead, WM1
Jönson, C1
Fändriks, L1

Other Studies

18 other studies available for prazosin and Hemorrhage

ArticleYear
Altered mesenteric venous capacitance and volume pooling in cirrhotic rats are mediated by nitric oxide.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 295, Issue:2

    Topics: Animals; Blood Volume; Hemorrhage; Liver Cirrhosis, Experimental; Mesenteric Veins; NG-Nitroarginine

2008
Central acetylcholinesterase inhibition improves hemodynamic counterregulation to severe blood loss in alcohol-intoxicated rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:2

    Topics: Alcoholic Intoxication; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Bl

2009
Effects of alpha-adrenergic activation on the shift of electrolytes and fluid after hemorrhage in rats.
    The Japanese journal of physiology, 1995, Volume: 45, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Body Fluids; Electrolytes; Hemodynamics; Hemorrh

1995
Nonlinear analysis of BP signal. Can it detect malfunctions in BP control?
    The American journal of physiology, 1996, Volume: 271, Issue:2 Pt 2

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Hemorrhage; Models, Cardiovascular; Prazosin;

1996
Insight into blood-pressure control in SHR via the response to acute hemorrhage: a spectral analysis approach.
    Journal of the autonomic nervous system, 1995, Nov-06, Volume: 55, Issue:3

    Topics: Acute Disease; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin-Co

1995
Effects of graded hemorrhage on short-term variability of blood pressure in conscious rats.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:6

    Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Gas Analysis; Blood Pressure; Blood Prot

1996
Effect of haemorrhage on the power of low frequency blood pressure fluctuations in young spontaneously hypertensive rats.
    Clinical and experimental pharmacology & physiology. Supplement, 1995, Volume: 22, Issue:1

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon

1995
Hemorrhage induces acute cardioadaptation to ischemia-reperfusion by an alpha1-adrenoceptor-mediated, protein synthesis-independent mechanism.
    The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 2

    Topics: Adaptation, Physiological; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Coronary Circulati

1997
Alpha-adrenergic activation of myocardial NF kappa B during hemorrhage.
    The Journal of surgical research, 1997, Volume: 69, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cell Nucleus; Coronary Circulation; Cytoplasm

1997
Contribution of humoral systems to the short-term variability of blood pressure after severe hemorrhage.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: Animals; Antihypertensive Agents; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Carbon D

1997
Contribution of humoral systems to the recovery of blood pressure following severe haemorrhage.
    Journal of autonomic pharmacology, 1997, Volume: 17, Issue:5

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Anti

1997
Hemorrhage-induced alpha-adrenergic signaling results in myocardial TNF-alpha expression and contractile dysfunction.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 281, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Hemorrhage; Male; Myocardial Contr

2001
Sympathoinhibition and its reversal by naloxone during hemorrhage.
    The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 2

    Topics: Analysis of Variance; Animals; Blood Pressure; Heart Rate; Hemodynamics; Hemorrhage; Kidney; Male; N

1992
Adrenergic mediation of vasopressin secretion in newborn pigs.
    The American journal of physiology, 1987, Volume: 253, Issue:3 Pt 2

    Topics: Animals; Animals, Newborn; Blood Pressure; Hemorrhage; Hydrogen-Ion Concentration; Lypressin; Prazos

1987
Endocrine responses of fetal lambs to hemorrhage after alpha 1-adrenergic receptor blockade.
    American journal of obstetrics and gynecology, 1988, Volume: 159, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Endocrine Glands; Hemodynamics; Hemorrhage; Hydrocortisone; P

1988
Adrenergic receptors of adrenal medullary vasculature.
    The American journal of physiology, 1989, Volume: 256, Issue:1 Pt 2

    Topics: Adrenal Medulla; Animals; Catecholamines; Dogs; Hemorrhage; Hypotension; Microspheres; Pindolol; Pra

1989
Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs.
    The American journal of physiology, 1988, Volume: 254, Issue:4 Pt 2

    Topics: Animals; Animals, Newborn; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Hemor

1988
Bleeding-induced decrease in duodenal HCO3- secretion in the rat is mediated via alpha 2-adrenoceptors.
    Acta physiologica Scandinavica, 1987, Volume: 130, Issue:3

    Topics: Animals; Bicarbonates; Duodenum; Guanethidine; Hemorrhage; Male; Prazosin; Propranolol; Rats; Rats,

1987