prazosin has been researched along with Granulocytic Leukemia, Chronic in 4 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Active influx of imatinib in chronic myeloid leukemia (CML) cells is mediated by the organic cation transporter 1 (OCT-1)." | 1.36 | Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. ( Engler, JR; Frede, A; Hughes, TP; Saunders, VA; White, DL; Zannettino, AC, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eadie, LN | 1 |
| Hughes, TP | 3 |
| White, DL | 3 |
| Engler, JR | 1 |
| Frede, A | 1 |
| Saunders, VA | 1 |
| Zannettino, AC | 1 |
| Eadie, L | 1 |
| Forchap, SL | 1 |
| Pirmohamed, M | 1 |
| Clark, RE | 1 |
4 other studies available for prazosin and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Patients with low OCT-1 activity and high ABCB1 fold rise have poor long-term outcomes in response to tyrosine kinase inhibitor therapy.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Humans; Imatinib Mesylate; Leu | 2018 |
Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity.
Topics: Adrenergic alpha-Antagonists; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B; ATP Bin | 2010 |
Nilotinib does not significantly reduce imatinib OCT-1 activity in either cell lines or primary CML cells.
Topics: Adrenergic alpha-Antagonists; Benzamides; Drug Therapy, Combination; Humans; Imatinib Mesylate; Leuk | 2010 |
Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis.
Topics: Amantadine; Apoptosis; Calcium; Caspases; Cell Membrane Permeability; Drug Synergism; Humans; K562 C | 2012 |