Page last updated: 2024-11-03

prazosin and Gelineau Syndrome

prazosin has been researched along with Gelineau Syndrome in 8 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Research Excerpts

ExcerptRelevanceReference
" Experiments have shown that prazosin, an alpha 1 antagonist, dramatically aggravates canine narcolepsy-cataplexy through a central mechanism, and that [3H]prazosin binding sites are increased in the amygdala of narcoleptic dogs."3.67Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep. ( Bowersox, S; Ciaranello, R; Dement, WC; Frusthofer, B; Guilleminault, C; Maddaluno, J; Mignot, E; Nishino, S, 1989)
"Narcolepsy is a genetically determined disorder of sleep characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep that affects both humans and animals."1.29Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. ( Arrigoni, J; Ciaranello, RD; Dement, WC; Edgar, DM; Mignot, E; Nishino, S; Reid, MS; Sharp, LH; Siegel, JM, 1993)
"Canine narcolepsy is an animal model of the human rapid eye movement sleep disorder."1.28Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep. ( Dement, WC; Guilleminault, C; Mignot, E; Nishino, S; Renaud, A, 1991)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's3 (37.50)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mignot, E7
Nishino, S4
Sharp, LH1
Arrigoni, J2
Siegel, JM2
Reid, MS1
Edgar, DM1
Ciaranello, RD1
Dement, WC6
Fruhstorfer, B1
Guilleminault, C6
Gulyani, S1
Wu, MF1
Nienhuis, R1
John, J1
Renaud, A1
Bowersox, S3
Frusthofer, B1
Maddaluno, J1
Ciaranello, R1
Rappaport, A2
Aldrich, M1
Quera-Salva, MA1
Tiberge, M1
Partinen, M1

Other Studies

8 other studies available for prazosin and Gelineau Syndrome

ArticleYear
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:3

    Topics: Aging; Animals; Azepines; Biogenic Amines; Brain; Cataplexy; Chromosome Mapping; Crosses, Genetic; D

1993
Further characterization of the alpha-1 receptor subtype involved in the control of cataplexy in canine narcolepsy.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cataplexy; D

1993
Cataplexy-related neurons in the amygdala of the narcoleptic dog.
    Neuroscience, 2002, Volume: 112, Issue:2

    Topics: Action Potentials; Adrenergic alpha-Antagonists; Amygdala; Animals; Cataplexy; Cerebral Cortex; Dise

2002
Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep.
    European journal of pharmacology, 1991, Nov-19, Volume: 205, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Body Temperature; Bridged Bicyclo Compounds; Bri

1991
Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
    Brain research, 1989, Jun-19, Volume: 490, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cataplexy; Clonidine; Dioxanes; Dogs; Narcolepsy; Phen

1989
Effect of alpha 1-adrenoceptors blockade with prazosin in canine narcolepsy.
    Brain research, 1988, Mar-15, Volume: 444, Issue:1

    Topics: Animals; Brain; Dog Diseases; Dogs; Genetic Carrier Screening; Male; Narcolepsy; Organ Specificity;

1988
Role of central alpha-1 adrenoceptors in canine narcolepsy.
    The Journal of clinical investigation, 1988, Volume: 82, Issue:3

    Topics: Animals; Blood Pressure; Cataplexy; Dogs; Drug Combinations; Food; Heart Rate; Heterozygote; Homozyg

1988
Prazosin contraindicated in patients with narcolepsy.
    Lancet (London, England), 1988, Aug-27, Volume: 2, Issue:8609

    Topics: Aged; Cataplexy; Female; Humans; Hypertension; Male; Middle Aged; Narcolepsy; Prazosin

1988