prazosin has been researched along with Gelineau Syndrome in 8 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Experiments have shown that prazosin, an alpha 1 antagonist, dramatically aggravates canine narcolepsy-cataplexy through a central mechanism, and that [3H]prazosin binding sites are increased in the amygdala of narcoleptic dogs." | 3.67 | Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep. ( Bowersox, S; Ciaranello, R; Dement, WC; Frusthofer, B; Guilleminault, C; Maddaluno, J; Mignot, E; Nishino, S, 1989) |
| "Narcolepsy is a genetically determined disorder of sleep characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep that affects both humans and animals." | 1.29 | Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. ( Arrigoni, J; Ciaranello, RD; Dement, WC; Edgar, DM; Mignot, E; Nishino, S; Reid, MS; Sharp, LH; Siegel, JM, 1993) |
| "Canine narcolepsy is an animal model of the human rapid eye movement sleep disorder." | 1.28 | Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep. ( Dement, WC; Guilleminault, C; Mignot, E; Nishino, S; Renaud, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mignot, E | 7 |
| Nishino, S | 4 |
| Sharp, LH | 1 |
| Arrigoni, J | 2 |
| Siegel, JM | 2 |
| Reid, MS | 1 |
| Edgar, DM | 1 |
| Ciaranello, RD | 1 |
| Dement, WC | 6 |
| Fruhstorfer, B | 1 |
| Guilleminault, C | 6 |
| Gulyani, S | 1 |
| Wu, MF | 1 |
| Nienhuis, R | 1 |
| John, J | 1 |
| Renaud, A | 1 |
| Bowersox, S | 3 |
| Frusthofer, B | 1 |
| Maddaluno, J | 1 |
| Ciaranello, R | 1 |
| Rappaport, A | 2 |
| Aldrich, M | 1 |
| Quera-Salva, MA | 1 |
| Tiberge, M | 1 |
| Partinen, M | 1 |
8 other studies available for prazosin and Gelineau Syndrome
| Article | Year |
|---|---|
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.
Topics: Aging; Animals; Azepines; Biogenic Amines; Brain; Cataplexy; Chromosome Mapping; Crosses, Genetic; D | 1993 |
Further characterization of the alpha-1 receptor subtype involved in the control of cataplexy in canine narcolepsy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cataplexy; D | 1993 |
Cataplexy-related neurons in the amygdala of the narcoleptic dog.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Amygdala; Animals; Cataplexy; Cerebral Cortex; Dise | 2002 |
Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Body Temperature; Bridged Bicyclo Compounds; Bri | 1991 |
Central alpha 1 adrenoceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cataplexy; Clonidine; Dioxanes; Dogs; Narcolepsy; Phen | 1989 |
Effect of alpha 1-adrenoceptors blockade with prazosin in canine narcolepsy.
Topics: Animals; Brain; Dog Diseases; Dogs; Genetic Carrier Screening; Male; Narcolepsy; Organ Specificity; | 1988 |
Role of central alpha-1 adrenoceptors in canine narcolepsy.
Topics: Animals; Blood Pressure; Cataplexy; Dogs; Drug Combinations; Food; Heart Rate; Heterozygote; Homozyg | 1988 |
Prazosin contraindicated in patients with narcolepsy.
Topics: Aged; Cataplexy; Female; Humans; Hypertension; Male; Middle Aged; Narcolepsy; Prazosin | 1988 |