prazosin has been researched along with Disease Models, Animal in 123 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When applied topically, oxymetazoline and brimonidine reduce the persistent facial erythema of rosacea; this effect is mediated by cutaneous vasoconstriction induced by postsynaptic activation of α-adrenoceptors." | 7.88 | Reduction in ultraviolet B light-induced erythema by oxymetazoline and brimonidine is mediated by different α-adrenoceptors. ( Gil, D; Hsia, E; Tian, M, 2018) |
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 7.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission." | 7.72 | Inhibitory actions of endothelin-1 on pain processing. ( Fukuda, Y; Hasue, F; Kuwaki, T; Shimoyama, M; Yamada, H, 2004) |
| "S-antigen (S-Ag)-induced experimental autoimmune uveoretinitis (EAU) was suppressed in Lewis and PVG rats by treatment beginning 4 days post immunization with prazosin, a specific alpha 1-adrenergic receptor antagonist." | 7.68 | Suppression of experimental autoimmune uveoretinitis by prazosin, an alpha 1-adrenergic receptor antagonist. ( de Kozak, Y; Misiuk-Hojlo, M; Ruiz-Moreno, JM; Thillaye, B, 1992) |
| "Effects of prazosin, dobutamine, isoproterenol and SGB-1534, a new alpha-blockade, on congestive heart failure (CHF) in dogs were investigated." | 7.67 | [Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs]. ( Sonoki, H; Sugimoto, T; Tomaru, T; Uchida, Y, 1988) |
| "The effects of dexamethasone, cyclosporin A and prazosin were investigated in an animal model of retinal vasculitis." | 7.67 | Modulation of experimental retinal vasculitis using dexamethasone, cyclosporin A, and prazosin. ( Atkinson, E; Dumonde, DC; Kasp, E; Stanford, MR, 1987) |
| " However, prazosin did not have nicotine-like discriminative effects and did not alter the dose-response curve for nicotine discrimination." | 5.36 | Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. ( Forget, B; Goldberg, SR; Le Foll, B; Mascia, P; Pushparaj, A; Wertheim, C, 2010) |
| "The antimyopia treatments atropine, apomorphine, and intense light all significantly inhibited myopia development and the decrease in ChBP." | 3.96 | Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs. ( Chen, Y; Lei, Y; Qu, J; Xiang, J; Xu, R; Zhang, G; Zhang, S; Zhou, X, 2020) |
| " The alpha-1 adrenoceptor antagonist prazosin has been investigated as a treatment for alcoholism and for chronic stress disorders that are frequently comorbid with alcoholism." | 3.91 | Effects of the Alpha-1 Antagonist Prazosin on KOR Agonist-Induced Reinstatement of Alcohol Seeking. ( Coen, K; Funk, D; Lê, AD; Tamadon, S, 2019) |
| "When applied topically, oxymetazoline and brimonidine reduce the persistent facial erythema of rosacea; this effect is mediated by cutaneous vasoconstriction induced by postsynaptic activation of α-adrenoceptors." | 3.88 | Reduction in ultraviolet B light-induced erythema by oxymetazoline and brimonidine is mediated by different α-adrenoceptors. ( Gil, D; Hsia, E; Tian, M, 2018) |
| "Prazosin decreases alcohol intake in P rats even in a situation that would be expected to increase alcohol drinking, namely following periods of alcohol deprivation." | 3.81 | Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse. ( Fischer, S; Froehlich, JC; Hausauer, B; Rasmussen, DD; Wise, B, 2015) |
| "The drug composition formed by anisodamine and prazosin has good effects of relaxing extremities tiny blood vessels and it can fight against thrombosis, its antithrombotic mechanisms may be related to the influence of the extrinsic coagulation pathway, inhibition of platelet activation functions and the promotion of fibrinolysis function." | 3.80 | [Novel drug composition ameliorating thrombosis and its molecular mechanisms]. ( Cui, WY; Huang, JH; Ning, M; Wang, H; Zhang, YF, 2014) |
| " This study investigated the effect of the interaction of melatonin and agmatine on seizure susceptibility in the mouse model of pentylenetetrazole (PTZ)-induced clonic seizures." | 3.77 | The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. ( Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H, 2011) |
| "5, and 2 mg/kg) of alpha1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas alpha2-AR antagonist yohimbine exacerbated it." | 3.73 | Effects of alpha1- and alpha2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| ") significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0." | 3.73 | Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. ( Hwang, BG; Kim, JH; Kim, SK; Min, BI; Na, HS; Park, DS; Yoo, GY, 2005) |
| "Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission." | 3.72 | Inhibitory actions of endothelin-1 on pain processing. ( Fukuda, Y; Hasue, F; Kuwaki, T; Shimoyama, M; Yamada, H, 2004) |
| "The effect of adrenoceptor blockers on nicotine induced hyperglycemia were studied in fasted normal and thyroidectomised rats." | 3.70 | Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats. ( Fasanmade, AA; Ogwumike, OO, 2000) |
| "Thyroxine treatment was sufficient to induce a significant degree of tachycardia (423+/-6 vs 353+/-4 bpm, P < 0." | 3.70 | Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism. ( Elghozi, JL; Laude, D; Ponchon, P; Safa-Tisseront, V, 1998) |
| "This study was performed to assess the effects of subacute sepsis in rats on the in vitro reactivity of arterioles (internal diameter, 100-150 microm) to alpha1- and alpha2-adrenergic stimulation and to angiotensin II." | 3.70 | Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis. ( Cameron, EM; Fink, MP; Sellke, FW; Wang, SY, 1998) |
| "S-antigen (S-Ag)-induced experimental autoimmune uveoretinitis (EAU) was suppressed in Lewis and PVG rats by treatment beginning 4 days post immunization with prazosin, a specific alpha 1-adrenergic receptor antagonist." | 3.68 | Suppression of experimental autoimmune uveoretinitis by prazosin, an alpha 1-adrenergic receptor antagonist. ( de Kozak, Y; Misiuk-Hojlo, M; Ruiz-Moreno, JM; Thillaye, B, 1992) |
| "The effect of doxazosin administration on hemodynamics, hemostasis, and serum lipid and lipoprotein levels was investigated in cynomolgus monkeys (Macaca fascicularis) with diet-induced hypercholesterolemia." | 3.67 | Serum lipids, lipoproteins, hemodynamics, and hemostasis in doxazosin-treated monkeys. ( Karge, WH; Kowala, MC; Nicolosi, RJ; Weiner, EJ, 1989) |
| "Effects of prazosin, dobutamine, isoproterenol and SGB-1534, a new alpha-blockade, on congestive heart failure (CHF) in dogs were investigated." | 3.67 | [Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs]. ( Sonoki, H; Sugimoto, T; Tomaru, T; Uchida, Y, 1988) |
| "The effects of dexamethasone, cyclosporin A and prazosin were investigated in an animal model of retinal vasculitis." | 3.67 | Modulation of experimental retinal vasculitis using dexamethasone, cyclosporin A, and prazosin. ( Atkinson, E; Dumonde, DC; Kasp, E; Stanford, MR, 1987) |
| "To examine the relationships between the central and peripheral renin angiotensin system in normotensive Wistar Kyoto (WKY) rats, two-kidney, one-clip Goldblatt renovascular hypertension (RVH), spontaneously hypertensive rats (SHR), SQ 14225 (captopril) was administered intraventricularly (IVT) and intravenously (IV) in the alternative manner and their combination." | 3.67 | Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. ( Itaya, Y; Kageyama, Y; Kondo, K; Matsukawa, S; Saruta, T; Suzuki, H, 1986) |
| "In an orthotopic murine model of pancreatic cancer, AES-135 prolongs survival significantly, therefore representing a candidate for further preclinical testing." | 1.51 | Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. ( Adile, AA; Bakhshinyan, D; Berger-Becvar, A; de Araujo, ED; Deininger, MW; Fishel, ML; Gawel, JM; Geletu, M; Grimard, ML; Gunning, PT; Heaton, WL; Konieczny, SF; Luchman, HA; O'Hare, T; Raouf, YS; Shah, F; Shouksmith, AE; Singh, SK; Venugopal, C; Weiss, S, 2019) |
| " However, relationship between stroke incidence and triptan use is unclear, and it is unknown whether acute or chronic use of these drugs worsens ischemic brain injury." | 1.46 | Acute and chronic triptan exposure neither alters rodent cerebral blood flow nor worsens ischemic brain injury. ( Buonvicino, D; Chiarugi, A; De Cesaris, F; Muzzi, M, 2017) |
| "Established allodynia (by day 21) was partly reversed by the re-uptake inhibitor reboxetine (5 μg, i." | 1.39 | Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. ( Hickey, L; Hughes, SW; Hulse, RP; Lumb, BM; Pickering, AE, 2013) |
| "Male rats received partial bladder outlet obstruction or sham surgery were used." | 1.37 | Alpha1-adrenoceptor antagonists improve bladder storage function through reduction of afferent activity in rats with bladder outlet obstruction. ( Aikawa, K; Haga, N; Ishibashi, K; Nomiya, M; Shishido, K; Yamaguchi, O; Yanagida, T; Yazaki, J, 2011) |
| "Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder precipitated by exposure to extreme traumatic stress." | 1.37 | The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder. ( Defino, MC; Hague, C; Olson, VG; Peskind, ER; Raskind, MA; Redila, VA; Reh, RK; Rockett, HR; Szot, P; Tran, PM; Venkov, HA, 2011) |
| "Carvacrol (cvc) was administered orally at single doses of 12." | 1.37 | Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system. ( de Sousa, DP; de Sousa, FC; de Vasconcelos, SM; Fonteles, MM; Macedo, DS; Melo, FH; Moura, BA; Viana, GS, 2011) |
| " However, prazosin did not have nicotine-like discriminative effects and did not alter the dose-response curve for nicotine discrimination." | 1.36 | Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction. ( Forget, B; Goldberg, SR; Le Foll, B; Mascia, P; Pushparaj, A; Wertheim, C, 2010) |
| "Tesofensine is a novel monoamine reuptake inhibitor that inhibits both norepinephrine, 5-HT, and dopamine (DA) reuptake function." | 1.36 | Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. ( Axel, AM; Hansen, HH; Mikkelsen, JD, 2010) |
| "Adenosine has been shown to exert direct antihypertrophic effects on the heart, and plasma adenosine levels have been shown to be elevated in patients with heart failure." | 1.36 | Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes. ( Cook, MA; Freeman, DJ; Gan, XT; Karmazyn, M; Pang, T, 2010) |
| " Prazosin prevented hepatotoxicity when administered 1 h before a toxic paracetamol insult and importantly, when administered up to 1 h post paracetamol injection." | 1.35 | alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice. ( Kitteringham, NR; Macdonald, I; Park, BK; Randle, LE; Sathish, JG; Williams, DP, 2008) |
| " Chronic use of TCA drugs increases the expression of alpha(1)-adrenergic receptors (alpha(1)-ARs)." | 1.35 | alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. ( Darsie, B; Doze, VA; Handel, EM; Haselton, JR; Jensen, KA; Luger, EJ; Rorabaugh, BR; Talbot, JN, 2009) |
| "This study tested the hypothesis that acute pancreatitis decreases alveolar fluid clearance in a rat model of pulmonary oedema during acute pancreatitis." | 1.35 | Endogenous catecholamine stimulates alveolar fluid clearance in rats with acute pancreatitis. ( Ma, G; Sagawa, M; Sakuma, T; Shimazaki, M; Ueda, Y; Wang, Z; Xu, J, 2009) |
| "Phase 2 arrhythmias appear to depend in part on a complex interaction between catecholamines and neutrophils." | 1.35 | Complex adrenergic and inflammatory mechanisms contribute to phase 2 ventricular arrhythmias in anaesthetized rats. ( Andrag, E; Clements-Jewery, H; Curtis, MJ; Hearse, DJ, 2009) |
| "Hyperhomocysteinemia is a known risk factor for cardiovascular diseases, but the underlying mechanisms of this pathology are complex." | 1.33 | Alpha1D-adrenoceptor-induced relaxation on rat carotid artery is impaired during the endothelial dysfunction evoked in the early stages of hyperhomocysteinemia. ( Cunha, FQ; de Andrade, CR; de Godoy, MA; de Oliveira, AM; de Souza, HP; Eberlin, MN; Fukada, SY; Haddad, R; Laurindo, FR; Olivon, VC, 2006) |
| "Hormone treatment induced benign prostatic hyperplasia and resulted in detrusor overactivity, as determined by cystometry." | 1.33 | A selective alpha1A-adrenoceptor antagonist inhibits detrusor overactivity in a rat model of benign prostatic hyperplasia. ( Akiyama, K; Kobayashi, M; Tatemichi, S; Uruno, T; Yamazaki, Y; Yokoyama, O, 2006) |
| "Hearts from animal models of type 2 diabetes present with abnormal contractility patterns." | 1.32 | A role for the alpha1-adrenergic signalling pathway in the response of papillary muscles from type 2 diabetic hearts to anoxia-reoxygenation. ( Huisamen, B; Lochner, A; Upton, J, 2004) |
| "Ventricular fibrillation was untreated for 7 minutes before the start of precordial compression, mechanical ventilation, and attempted defibrillation." | 1.32 | Evidence favoring the use of an alpha2-selective vasopressor agent for cardiopulmonary resuscitation. ( Checchia, P; Pellis, T; Song, L; Sun, S; Tang, W; Weil, MH; Xie, J, 2003) |
| "Both prazosin and pentolinium elicited orthostatic hypotension under all four anesthetic conditions." | 1.30 | A rabbit model for evaluation of chlorpromazine-induced orthostatic hypotension. ( Kato, H; Kurihara, J; Okubo, Y; Suzuki, S; Takata, Y, 1999) |
| "Pretreatment with prazosin (100 micrograms/kg s." | 1.29 | Are the cardiovascular effects and '5-HT syndrome' induced by MDL 73,975 and flesinoxan in the dog mediated by 5-HT1A receptors? ( Di Francesco, GF, 1994) |
| "Nicotine caused an increase in respiratory rate and this effect was abolished by prazosin." | 1.29 | Effects of adrenoceptor blockers on the cardiorespiratory response to nicotine in rats. ( Fasanmade, AA; Oyebola, DD, 1993) |
| "Postural hypotension was observed in the prazosin treatment group, but not following administration of felodipine." | 1.29 | omega-Conotoxin GVIA and prazosin, but not felodipine, cause postural hypotension in rabbits. ( Angus, JA; Hawkes, AL; Wright, CE, 1995) |
| "We have previously demonstrated that cataplexy is strongly inhibited by increases in noradrenergic activity." | 1.28 | Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep. ( Dement, WC; Guilleminault, C; Mignot, E; Nishino, S; Renaud, A, 1991) |
| "In previously untreated rats, pretreatment with enalaprilat shifted the dose-response curve for the hypotensive effect of doxazosin to the left, indicating synergism." | 1.28 | A study of the interaction between the hypotensive actions of doxazosin and enalaprilat in anaesthetized rats. ( Marwood, JF; Stokes, GS; Tierney, G, 1992) |
| "Postural hypotension is a common side effect observed in the treatment of hypertension with various drugs." | 1.27 | Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine. ( Bartsch, W; Böhm, E; Hooper, RG; Sponer, G; Strein, K, 1987) |
| "[3H]Yohimbine binding sites were not significantly altered." | 1.27 | Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma. ( Hashimoto, K; Hoffman, BB; Honda, K; Tsujimoto, G, 1987) |
| "Protection from arrhythmias seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation." | 1.27 | The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. ( Schwartz, PJ; Vanoli, E; Zaza, A; Zuanetti, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (12.20) | 18.7374 |
| 1990's | 24 (19.51) | 18.2507 |
| 2000's | 39 (31.71) | 29.6817 |
| 2010's | 41 (33.33) | 24.3611 |
| 2020's | 4 (3.25) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Shouksmith, AE | 1 |
| Shah, F | 1 |
| Grimard, ML | 1 |
| Gawel, JM | 1 |
| Raouf, YS | 1 |
| Geletu, M | 1 |
| Berger-Becvar, A | 1 |
| de Araujo, ED | 1 |
| Luchman, HA | 1 |
| Heaton, WL | 1 |
| Bakhshinyan, D | 1 |
| Adile, AA | 1 |
| Venugopal, C | 1 |
| O'Hare, T | 1 |
| Deininger, MW | 1 |
| Singh, SK | 1 |
| Konieczny, SF | 1 |
| Weiss, S | 1 |
| Fishel, ML | 1 |
| Gunning, PT | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Funk, D | 1 |
| Coen, K | 1 |
| Tamadon, S | 1 |
| Lê, AD | 1 |
| Hicks, C | 1 |
| Sabino, V | 1 |
| Cottone, P | 1 |
| Zhou, X | 2 |
| Zhang, S | 1 |
| Zhang, G | 1 |
| Chen, Y | 1 |
| Lei, Y | 1 |
| Xiang, J | 1 |
| Xu, R | 1 |
| Qu, J | 1 |
| Shen, Y | 1 |
| Ma, HX | 1 |
| Lu, H | 1 |
| Zhao, HT | 1 |
| Sun, JL | 1 |
| Cheng, Y | 1 |
| Zhang, HH | 1 |
| Boyd, PJ | 1 |
| Tu, WY | 1 |
| Shorrock, HK | 1 |
| Groen, EJN | 1 |
| Carter, RN | 1 |
| Powis, RA | 1 |
| Thomson, SR | 1 |
| Thomson, D | 1 |
| Graham, LC | 1 |
| Motyl, AAL | 1 |
| Wishart, TM | 1 |
| Highley, JR | 1 |
| Morton, NM | 1 |
| Becker, T | 1 |
| Becker, CG | 1 |
| Heath, PR | 1 |
| Gillingwater, TH | 1 |
| Wang, L | 2 |
| Xue, Y | 1 |
| Ma, H | 1 |
| Shi, H | 1 |
| Cui, X | 1 |
| Hsia, E | 1 |
| Tian, M | 1 |
| Gil, D | 1 |
| Hughes, SW | 1 |
| Hickey, L | 1 |
| Hulse, RP | 1 |
| Lumb, BM | 1 |
| Pickering, AE | 1 |
| Song, Z | 1 |
| Ansah, OB | 1 |
| Meyerson, BA | 1 |
| Pertovaara, A | 1 |
| Linderoth, B | 1 |
| Laitman, BM | 1 |
| Gajewski, ND | 1 |
| Mann, GL | 1 |
| Kubin, L | 2 |
| Morrison, AR | 1 |
| Ross, RJ | 1 |
| Ning, M | 1 |
| Huang, JH | 1 |
| Zhang, YF | 1 |
| Cui, WY | 1 |
| Wang, H | 1 |
| Palotai, M | 1 |
| Telegdy, G | 2 |
| Tanaka, M | 1 |
| Bagosi, Z | 1 |
| Jászberényi, M | 1 |
| Sekio, M | 1 |
| Seki, K | 1 |
| Cummins Jacklin, E | 1 |
| Boughner, E | 1 |
| Kent, K | 1 |
| Kwiatkowski, D | 1 |
| MacDonald, T | 1 |
| Leri, F | 1 |
| Suita, K | 1 |
| Fujita, T | 1 |
| Hasegawa, N | 1 |
| Cai, W | 1 |
| Jin, H | 1 |
| Hidaka, Y | 1 |
| Prajapati, R | 1 |
| Umemura, M | 1 |
| Yokoyama, U | 1 |
| Sato, M | 1 |
| Okumura, S | 1 |
| Ishikawa, Y | 1 |
| Froehlich, JC | 1 |
| Hausauer, B | 1 |
| Fischer, S | 1 |
| Wise, B | 1 |
| Rasmussen, DD | 1 |
| Lai, CT | 1 |
| Chen, CY | 1 |
| Kuo, TB | 1 |
| Chern, CM | 1 |
| Yang, CC | 1 |
| Ogon, I | 1 |
| Takebayashi, T | 1 |
| Miyakawa, T | 1 |
| Iwase, T | 1 |
| Tanimoto, K | 1 |
| Terashima, Y | 1 |
| Jimbo, S | 1 |
| Kobayashi, T | 1 |
| Tohse, N | 1 |
| Yamashita, T | 1 |
| Vickers, SP | 1 |
| Hackett, D | 1 |
| Murray, F | 1 |
| Hutson, PH | 1 |
| Heal, DJ | 1 |
| Feenstra, MGP | 1 |
| Klompmakers, A | 1 |
| Figee, M | 1 |
| Fluitman, S | 1 |
| Vulink, N | 1 |
| Westenberg, HGM | 1 |
| Denys, D | 1 |
| Assad Kahn, S | 1 |
| Costa, SL | 1 |
| Gholamin, S | 1 |
| Nitta, RT | 1 |
| Dubois, LG | 1 |
| Fève, M | 1 |
| Zeniou, M | 1 |
| Coelho, PL | 1 |
| El-Habr, E | 1 |
| Cadusseau, J | 1 |
| Varlet, P | 1 |
| Mitra, SS | 1 |
| Devaux, B | 1 |
| Kilhoffer, MC | 1 |
| Cheshier, SH | 1 |
| Moura-Neto, V | 1 |
| Haiech, J | 1 |
| Junier, MP | 1 |
| Chneiweiss, H | 1 |
| Muzzi, M | 1 |
| Buonvicino, D | 1 |
| De Cesaris, F | 1 |
| Chiarugi, A | 1 |
| Winter, KL | 1 |
| Isbister, GK | 1 |
| Schneider, JJ | 1 |
| Konstantakopoulos, N | 1 |
| Seymour, JE | 1 |
| Hodgson, WC | 1 |
| Byku, M | 1 |
| Macarthur, H | 1 |
| Westfall, TC | 1 |
| Stuchlík, A | 1 |
| Petrásek, T | 1 |
| Vales, K | 1 |
| Clements-Jewery, H | 1 |
| Andrag, E | 1 |
| Hearse, DJ | 1 |
| Curtis, MJ | 1 |
| Xu, J | 1 |
| Wang, Z | 1 |
| Ma, G | 1 |
| Sagawa, M | 1 |
| Shimazaki, M | 1 |
| Ueda, Y | 1 |
| Sakuma, T | 1 |
| Machado, DG | 2 |
| Bettio, LE | 1 |
| Cunha, MP | 1 |
| Capra, JC | 1 |
| Dalmarco, JB | 1 |
| Pizzolatti, MG | 2 |
| Rodrigues, AL | 2 |
| Doze, VA | 1 |
| Handel, EM | 1 |
| Jensen, KA | 1 |
| Darsie, B | 1 |
| Luger, EJ | 1 |
| Haselton, JR | 1 |
| Talbot, JN | 1 |
| Rorabaugh, BR | 1 |
| Tanibuchi, Y | 1 |
| Fujita, Y | 1 |
| Kohno, M | 1 |
| Ishima, T | 1 |
| Takatsu, Y | 1 |
| Iyo, M | 1 |
| Hashimoto, K | 2 |
| Pang, T | 1 |
| Gan, XT | 1 |
| Freeman, DJ | 1 |
| Cook, MA | 1 |
| Karmazyn, M | 1 |
| Freitas, AE | 1 |
| Budni, J | 1 |
| Lobato, KR | 1 |
| Binfaré, RW | 1 |
| Jacinto, J | 1 |
| Veronezi, PO | 1 |
| Axel, AM | 1 |
| Mikkelsen, JD | 1 |
| Hansen, HH | 1 |
| Nalepa, I | 1 |
| Vetulani, J | 1 |
| Borghi, V | 1 |
| Kowalska, M | 1 |
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1 review available for prazosin and Disease Models, Animal
| Article | Year |
|---|---|
Insulin resistance and hypertension.
Topics: Adipose Tissue; Animals; Captopril; Catecholamines; Disease Models, Animal; Fructose; Glucose Tolera | 1992 |
1 trial available for prazosin and Disease Models, Animal
| Article | Year |
|---|---|
Prazosin addition to fluvoxamine: A preclinical study and open clinical trial in OCD.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Animals; Antidepressive Agents; Area Under Curve; Di | 2016 |
121 other studies available for prazosin and Disease Models, Animal
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.
Topics: Animals; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease | 2019 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Effects of the Alpha-1 Antagonist Prazosin on KOR Agonist-Induced Reinstatement of Alcohol Seeking.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic | 2019 |
The Alpha-1 Adrenergic Receptor Antagonist Prazosin Reduces Binge-Like Eating in Rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Disease Models, Animal; Feeding and Eating Disorde | 2020 |
Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Atropine; Biometry; Choroid; Disease Models, Anima | 2020 |
Central deficiency of norepinephrine synthesis and norepinephrinergic neurotransmission contributes to seizure-induced respiratory arrest.
Topics: Acoustic Stimulation; Adrenergic alpha-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals | 2021 |
Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.
Topics: Adenosine Triphosphate; Animals; Axons; Disease Models, Animal; Disease Susceptibility; Energy Metab | 2017 |
Prazosin protects myocardial cells against anoxia-reoxygenation injury via the extracellular signal‑regulated kinase signaling pathway.
Topics: Animals; Apoptosis; Biomarkers; Blood Pressure; Cells, Cultured; Cytokines; Disease Models, Animal; | 2018 |
Reduction in ultraviolet B light-induced erythema by oxymetazoline and brimonidine is mediated by different α-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Dis | 2018 |
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Analysis of Varian | 2013 |
Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus.
Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; | 2013 |
The α1 adrenoceptor antagonist prazosin enhances sleep continuity in fear-conditioned Wistar-Kyoto rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Brain Waves; Conditioning, Psychological; Disease | 2014 |
[Novel drug composition ameliorating thrombosis and its molecular mechanisms].
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Disease Models, Animal; In Vitro Techniques; Male; | 2014 |
Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agent | 2014 |
Lipopolysaccharide-induced depressive-like behavior is associated with α₁-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Cell Membrane; Depression; Disease Models, Animal; | 2014 |
Memory of a drug lapse: Role of noradrenaline.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Animals; Basolateral | 2015 |
Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atrial Fibrillation; Calcium Sig | 2015 |
Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse.
Topics: Alcohol Abstinence; Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Male; Prazosin; R | 2015 |
Sympathetic Hyperactivity, Sleep Fragmentation, and Wake-Related Blood Pressure Surge During Late-Light Sleep in Spontaneously Hypertensive Rats.
Topics: Activity Cycles; Adrenergic alpha-1 Receptor Antagonists; Animals; Antihypertensive Agents; Barorefl | 2016 |
Attenuation of pain behaviour by local administration of alpha-2 adrenoceptor antagonists to dorsal root ganglia in a rat radiculopathy model.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2016 |
Effects of lisdexamfetamine in a rat model of binge-eating.
Topics: Animals; Baclofen; Behavior, Animal; Benzazepines; Benzodiazepines; Body Weight; Bulimia; Disease Mo | 2015 |
The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Topics: Animals; Antihypertensive Agents; Antineoplastic Agents; Apoptosis; Cell Survival; Disease Models, A | 2016 |
Acute and chronic triptan exposure neither alters rodent cerebral blood flow nor worsens ischemic brain injury.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Dihy | 2017 |
An examination of the cardiovascular effects of an 'Irukandji' jellyfish, Alatina nr mordens.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blotting, Western; Cardiovascular System; Cat | 2008 |
Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Age Factors; Angiotensin II; | 2008 |
Effect of alpha(1)-adrenergic antagonist prazosin on behavioral alterations induced by MK-801 in a spatial memory task in Long-Evans rats.
Topics: Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Malea | 2009 |
Complex adrenergic and inflammatory mechanisms contribute to phase 2 ventricular arrhythmias in anaesthetized rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Atenolol; | 2009 |
Endogenous catecholamine stimulates alveolar fluid clearance in rats with acute pancreatitis.
Topics: Acute Disease; Adrenalectomy; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bron | 2009 |
Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal | 2009 |
alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.
Topics: Adrenergic alpha-Agonists; Animals; Antidepressive Agents; Behavior, Animal; Brain; Catecholamines; | 2009 |
Effects of quetiapine on phencyclidine-induced cognitive deficits in mice: a possible role of alpha1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Cognition; | 2009 |
Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
Topics: Adenosine; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Heart V | 2010 |
Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Biogenic Monoami | 2010 |
Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Benzazepines; Body Weight; Bridged Bicy | 2010 |
Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analgesics; Animals; A | 2010 |
Noradrenergic alpha1 receptors as a novel target for the treatment of nicotine addiction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 2010 |
Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control.
Topics: Animals; Baroreflex; Blood Pressure Determination; Disease Models, Animal; Humans; Hypertension; Mic | 2010 |
Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepre | 2011 |
Chemical or surgical sympathectomy prevents mechanical hyperalgesia induced by intraplantar injection of bee venom in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals | 2010 |
Alpha1-adrenoceptor antagonists improve bladder storage function through reduction of afferent activity in rats with bladder outlet obstruction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Afferent Pathways; Analysis of Variance; Animals; Disease M | 2011 |
Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Cyproheptadine; Depression; Di | 2011 |
Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Brain Injuries; Disease Models, Animal; Epinephrin | 2011 |
Halothane-anesthetized rabbit: a new experimental model to test the effects of besipirdine and duloxetine on lower urinary tract function.
Topics: Anesthesia; Anesthetics; Animals; Atomoxetine Hydrochloride; Disease Models, Animal; Dose-Response R | 2011 |
The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder.
Topics: Acoustic Stimulation; Aggression; Animals; Brain Mapping; Clonidine; Disease Models, Animal; Electri | 2011 |
Sensitization in relation to posttraumatic stress disorder.
Topics: Acoustic Stimulation; Animals; Brain; Clonidine; Disease Models, Animal; Mice; Norepinephrine; Prazo | 2011 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Rela | 2011 |
Effect of chronic intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic Neurons; Animals; Disease Models, Animal; Hypogl | 2012 |
Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Bicuculline; Cyproh | 2012 |
Neurogenic vascular responses in male mouse mesenteric vascular beds.
Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Guanethi | 2012 |
Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease.
Topics: Adrenergic alpha-1 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease | 2013 |
Mice expressing the alpha(1B)-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation.
Topics: Adrenergic alpha-Antagonists; alpha-Synuclein; Animals; Body Weight; Brain; Cerebellum; Disease Mode | 2002 |
Evidence favoring the use of an alpha2-selective vasopressor agent for cardiopulmonary resuscitation.
Topics: Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Press | 2003 |
Pulmonary vascular responses to ma huang extract.
Topics: Adrenergic alpha-Antagonists; Animals; Cats; Disease Models, Animal; Dose-Response Relationship, Dru | 2003 |
Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amiloride; Ani | 2004 |
A role for the alpha1-adrenergic signalling pathway in the response of papillary muscles from type 2 diabetic hearts to anoxia-reoxygenation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biomarkers; Blood Glucose; Diabete | 2004 |
Effects of alpha1- and alpha2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Cold Tempe | 2005 |
Inhibitory actions of endothelin-1 on pain processing.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Ani | 2004 |
Effects of electroacupuncture on cold allodynia in a rat model of neuropathic pain: mediation by spinal adrenergic and serotonergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Cold Temperature; Disease Models, Animal; Dose-Response Relat | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2005 |
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
Alpha1D-adrenoceptor-induced relaxation on rat carotid artery is impaired during the endothelial dysfunction evoked in the early stages of hyperhomocysteinemia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carotid Arteries; Disease Models, | 2006 |
A selective alpha1A-adrenoceptor antagonist inhibits detrusor overactivity in a rat model of benign prostatic hyperplasia.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Disease Models, Anim | 2006 |
Cardio-protective role of terazosin is possibly mediated through alteration in thyroid function.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Cholesterol, Dietary; Disease Models, Animal; | 2006 |
Pumpkin seed oil and phytosterol-F can block testosterone/prazosin-induced prostate growth in rats.
Topics: Animals; Body Weight; Cucurbita; Disease Models, Animal; Drug Therapy, Combination; Male; Phytostero | 2006 |
Prazosin administered prior to inescapable stressor blocks subsequent exaggeration of acoustic startle response in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Electroshock; Epilepsy, Post-Traumati | 2007 |
The mechanisms of pain-induced pulmonary vasoconstriction: an experimental study in fetal lambs.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Fetal | 2007 |
Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Bloo | 2007 |
Coerulear activation by crh and its role in hypertension induced by prenatal malnutrition in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Corticosterone; Corticotropin-Releasi | 2007 |
Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.
Topics: Adenosine Triphosphate; Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; | 2007 |
Cervical spinal cord stimulation in cerebral ischemia.
Topics: Animals; Antihypertensive Agents; Brain Ischemia; Cervical Vertebrae; Disease Models, Animal; Electr | 2007 |
Increased alpha1-adrenergic activity in the rat bladder by depletion of ovarian hormones.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Disease Models, Animal; Female; Muscle | 2007 |
alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice.
Topics: Acetaminophen; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Catec | 2008 |
Increased pulmonary alpha-adrenergic and reduced beta-adrenergic receptors in experimental asthma.
Topics: Adenylyl Cyclases; Animals; Asthma; Dihydroalprenolol; Disease Models, Animal; Enzyme Activation; Gu | 1980 |
Disparate effects of prazosin and propranolol on lipid metabolism in a rat model.
Topics: Animals; Cholesterol; Disease Models, Animal; Hypertension; Lipid Metabolism; Lipoproteins, VLDL; Ma | 1983 |
A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Chlorisondamine; Disease Models, Animal; Hypotensi | 1983 |
Pancreatitis induced renal vasoconstriction.
Topics: Acute Kidney Injury; Animals; Bile; Disease Models, Animal; Dogs; Female; Fluid Therapy; Male; Pancr | 1982 |
Effect of alpha 1-adrenergic receptor antagonists on susceptibility to malignant arrhythmias: protection from ventricular fibrillation.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Disease Models, Animal; Dogs; Elect | 1994 |
The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atropine; Cats; Cerebral Ventricles; Di | 1995 |
Autonomic dysreflexia in a rat model spinal cord injury and the effect of pharmacologic agents.
Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System Diseases; Calcium Channel Blockers; | 1995 |
Are the cardiovascular effects and '5-HT syndrome' induced by MDL 73,975 and flesinoxan in the dog mediated by 5-HT1A receptors?
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Behavior, Animal; Blood Pressure; Disease Mo | 1994 |
Effects of adrenoceptor blockers on the cardiorespiratory response to nicotine in rats.
Topics: Animals; Disease Models, Animal; Drug Interactions; Hemodynamics; Male; Nicotine; Prazosin; Premedic | 1993 |
Effects of adrenergic receptor blockers on adrenaline and nicotine-induced hyperglycaemia in the rat.
Topics: Animals; Blood Glucose; Disease Models, Animal; Dogs; Epinephrine; Hyperglycemia; Male; Nicotine; Pr | 1993 |
The role of 5-hydroxytryptamine1A (5-HT1A) receptors in the anticonflict activity of beta-adrenoceptor antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Betaxolol; Conflict, Psychological; Disease Models, A | 1994 |
Effects of coronary artery occlusion and reperfusion on the idioventricular rate in anesthetized dogs.
Topics: Analysis of Variance; Animals; Coronary Disease; Disease Models, Animal; Dogs; Heart Block; Heart Ra | 1994 |
Inverse regulation of alpha- and beta-adrenoceptors during trinitrobenzenesulfonic acid (TNB)-induced inflammation in guinea-pig small intestine.
Topics: Animals; Dihydroalprenolol; Disease Models, Animal; Enteritis; Guinea Pigs; Intestinal Mucosa; Intes | 1993 |
omega-Conotoxin GVIA and prazosin, but not felodipine, cause postural hypotension in rabbits.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure | 1995 |
Pharmacological activity of DC-015, a novel potent and selective alpha 1-adrenoceptor antagonist.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age | 1996 |
An experimental model to study intracranial hypertension-induced vomiting in conscious dogs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Disease Models | 1996 |
Chronology and urodynamic characterization of micturition in neurohormonally induced experimental prostate growth in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Chronic Disease; Dihydrotestosterone; Disease Models, Animal; | 1998 |
Mesenteric and skeletal muscle microvascular responsiveness in subacute sepsis.
Topics: Angiotensin II; Animals; Blood Vessels; Disease Models, Animal; Hemodynamics; Male; Microcirculation | 1998 |
Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism.
Topics: Animals; Atenolol; Atropine; Autonomic Nervous System; Blood Pressure; Cardiomegaly; Disease Models, | 1998 |
A rabbit model for evaluation of chlorpromazine-induced orthostatic hypotension.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aorta; Blood Pressure; Cardiac Output; | 1999 |
The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzofurans; | 1999 |
Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Basal Ganglia; | 1999 |
Interaction between AT1 and alpha1-adrenergic receptors in cardiomyopathic hamsters.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Aorta; Cardiomyopathies; Cricetinae; Disease Models | 2000 |
Enhancement of antipsychotic-like effects by combined treatment with the alpha1-adrenoceptor antagonist prazosin and the dopamine D2 receptor antagonist raclopride in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antipsychotic Agents; Avoidance Learning; Cataleps | 2000 |
Mechanisms of the increased pressor response to vasopressors in the mesenteric bed of nitric oxide-deficient hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; D | 2001 |
Overstimulation of the alpha1B-adrenergic receptor causes a "seizure plus" syndrome.
Topics: Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Brain; Cerebral Cortex; Disease Models, | 2001 |
Effects of adrenoceptor blockers on the glycemic response to nicotine in thyroidectomised rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Disease Models, A | 2000 |
Effects of low-protein diet on the baroreflex and Bezold-Jarisch reflex in conscious rats.
Topics: Afferent Pathways; Animals; Baroreflex; Blood Pressure; Body Weight; Cardiovascular Physiological Ph | 2001 |
Cataplexy-related neurons in the amygdala of the narcoleptic dog.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Amygdala; Animals; Cataplexy; Cerebral Cortex; Dise | 2002 |
A study of the interaction between the hypotensive actions of doxazosin and enalaprilat in anaesthetized rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Desoxycorticosterone; Disease Models, Animal; Dose-Res | 1992 |
Suppression of experimental autoimmune uveoretinitis by prazosin, an alpha 1-adrenergic receptor antagonist.
Topics: Animals; Antigens; Arrestin; Autoantigens; Autoimmune Diseases; Capillary Permeability; Disease Mode | 1992 |
Development of a new rabbit ear model for the longitudinal study of digital pathophysiology.
Topics: Albuterol; Animals; Aorta, Abdominal; Blood Pressure; Catheterization, Peripheral; Clonidine; Diseas | 1992 |
Effects of SDZ NVI-085, a putative subtype-selective alpha 1-agonist, on canine cataplexy, a disorder of rapid eye movement sleep.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Body Temperature; Bridged Bicyclo Compounds; Bri | 1991 |
Rat salivary glands as a model for the study of adrenergic receptor modulation.
Topics: Animals; Autonomic Nervous System; Denervation; Dioxanes; Disease Models, Animal; Prazosin; Rats; Re | 1990 |
Evaluation of the risk for drug-induced postural hypotension in an experimental model: investigations with carvedilol, prazosin, labetalol, and guanethidine.
Topics: Animals; Blood Pressure; Carbazoles; Carvedilol; Disease Models, Animal; Guanethidine; Hypotension, | 1987 |
Serum lipids, lipoproteins, hemodynamics, and hemostasis in doxazosin-treated monkeys.
Topics: Adrenergic alpha-Antagonists; Animals; Apolipoproteins B; Disease Models, Animal; Doxazosin; Hemodyn | 1989 |
Effects of doxazosin on diet-induced hypercholesterolemia in C57BR/cdJ mice.
Topics: Adrenergic alpha-Antagonists; Animals; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Dise | 1987 |
Hemodynamic recovery during simulated ventricular tachycardia: role of adrenergic receptor activation.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiac Pacing, Artificial; Dise | 1988 |
[Effects of prazosin, SGB-1534, dobutamine and isoproterenol on congestive heart failure in dogs].
Topics: Adrenergic alpha-Antagonists; Animals; Disease Models, Animal; Dobutamine; Dogs; Heart Failure; Hemo | 1988 |
Hepatic alpha 1-adrenergic receptor alteration in a rat model of chronic sepsis.
Topics: Animals; Bacterial Infections; Chronic Disease; Dihydroergotoxine; Disease Models, Animal; Glucose; | 1986 |
Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma.
Topics: Angiotensins; Animals; Blood Pressure; Cell Membrane; Disease Models, Animal; Dopamine; Heart Rate; | 1987 |
Modulation of experimental retinal vasculitis using dexamethasone, cyclosporin A, and prazosin.
Topics: Animals; Cyclosporins; Dexamethasone; Disease Models, Animal; Fluorescein Angiography; Male; Prazosi | 1987 |
Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats.
Topics: Animals; Blood Pressure; Brain; Captopril; Disease Models, Animal; Hypertension; Hypertension, Renov | 1986 |
Noradrenergic rather than GABAergic processes as the common mediation of the antidepressant profile of GABA agonists and imipramine-like drugs in animals.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; | 1987 |
The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Disease M | 1985 |