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prazosin and Diabetes Mellitus, Type 2

prazosin has been researched along with Diabetes Mellitus, Type 2 in 15 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to evaluate the effectiveness and the safety of prazosin osmotic tablet treatment in non-insulin-dependent diabetic patients with mild to moderate arterial hypertension."9.09[Efficacy of and tolerance to prolonged release prazosin in patients with hypertension and non-insulin dependent diabetes]. ( Bernaud, C; Giacomino, A; Girerd, X; Hanon, O; Troy, S; Weber, S, 2000)
"The effects of the alpha-1-adrenergic blocker terazosin on blood pressure and fasting and postprandial glucose and lipid metabolism were assessed in type 2 diabetic patients with hypertension."9.09Effects of a 3-month treatment with terazosin on fasting and postprandial glucose and lipid metabolism in type 2 diabetic patients with hypertension. ( Ferrara, LA; Imperatore, G; Iovine, C; Pasanisi, F; Vaccaro, O, 1999)
"The effects of prazosin treatment on blood pressure and diabetic control were assessed in 22 patients with stable non-insulin-dependent diabetes mellitus and hypertension."7.67Effects of prazosin on blood pressure and diabetic control in patients with type II diabetes mellitus and mild essential hypertension. ( Levy, P, 1989)
"Doxazosin therapy was associated with opposite patterns of changes in fasting glucose, lipids and lipoproteins but only for serum triglyceride was difference between treatments significant."6.67Alpha-blocker therapy; a possible advance in the treatment of diabetic hypertension--results of a cross-over study of doxazosin and atenolol monotherapy in hypertensive non-insulin dependent diabetic subjects. ( Elkeles, RS; Feher, MD; Gelding, S; Henderson, AD; Poulter, C; Richmond, W; Sever, PS; Wadsworth, J, 1990)
"Doxazosin therapy was associated with a trend toward correcting the disturbances of lipoprotein metabolism characteristic of NIDDM."6.38Doxazosin therapy in the treatment of diabetic hypertension. ( Feher, MD, 1991)
"The aim of this study was to evaluate the effectiveness and the safety of prazosin osmotic tablet treatment in non-insulin-dependent diabetic patients with mild to moderate arterial hypertension."5.09[Efficacy of and tolerance to prolonged release prazosin in patients with hypertension and non-insulin dependent diabetes]. ( Bernaud, C; Giacomino, A; Girerd, X; Hanon, O; Troy, S; Weber, S, 2000)
"The effects of the alpha-1-adrenergic blocker terazosin on blood pressure and fasting and postprandial glucose and lipid metabolism were assessed in type 2 diabetic patients with hypertension."5.09Effects of a 3-month treatment with terazosin on fasting and postprandial glucose and lipid metabolism in type 2 diabetic patients with hypertension. ( Ferrara, LA; Imperatore, G; Iovine, C; Pasanisi, F; Vaccaro, O, 1999)
" In this article, doxazosin is reviewed for its efficacy in the treatment of severe essential hypertension and specific complications or conditions of mild or moderate essential hypertension, namely, left ventricular hypertrophy, hyperlipidemia, noninsulin-dependent diabetes mellitus, renal insufficiency, pheochromocytoma, chronic obstructive pulmonary disease, peripheral vascular disease, and smoking."4.78Efficacy of doxazosin in specific hypertensive patient groups. ( Taylor, SH, 1991)
" The effect of a 2-week treatment with nifedipine, captopril and prazosin upon glycaemia, serum insulin (IRI) and C-peptide (CP) following oral and intravenous glucose load were investigated in three groups, each including 10 non-diabetic patients with essential hypertension (h) and 10 hypertensive type 2 (non-insulin-dependent) diabetics (h + d), aged 32-63 years."3.69Effect of nifedipine, captopril and prazosin on secretory function of pancreatic beta-cells in hypertensive patients with type-2 (non-insulin-dependent) diabetes and in hypertensive non-diabetics. ( Czyzyk, A; Jasik, M; Kasperska-Dworak, A, 1996)
"The effects of prazosin treatment on blood pressure and diabetic control were assessed in 22 patients with stable non-insulin-dependent diabetes mellitus and hypertension."3.67Effects of prazosin on blood pressure and diabetic control in patients with type II diabetes mellitus and mild essential hypertension. ( Levy, P, 1989)
"CARDIOVASCULAR RISK OF LEFT VENTRICULAR HYPERTROPHY: Because of the rhythmic, mechanical and ischemic risk related to it, the left ventricular hypertrophy (LVH) is considered to be a major independent risk factor for cardiovascular disease which should be screened for and treated early."2.70[Management of hypertensive patients with left ventricular hypertrophy]. ( Ambrosioni, E, 2002)
"Doxazosin therapy was associated with opposite patterns of changes in fasting glucose, lipids and lipoproteins but only for serum triglyceride was difference between treatments significant."2.67Alpha-blocker therapy; a possible advance in the treatment of diabetic hypertension--results of a cross-over study of doxazosin and atenolol monotherapy in hypertensive non-insulin dependent diabetic subjects. ( Elkeles, RS; Feher, MD; Gelding, S; Henderson, AD; Poulter, C; Richmond, W; Sever, PS; Wadsworth, J, 1990)
"Doxazosin therapy was associated with a trend toward correcting the disturbances of lipoprotein metabolism characteristic of NIDDM."2.38Doxazosin therapy in the treatment of diabetic hypertension. ( Feher, MD, 1991)
"Hearts from animal models of type 2 diabetes present with abnormal contractility patterns."1.32A role for the alpha1-adrenergic signalling pathway in the response of papillary muscles from type 2 diabetic hearts to anoxia-reoxygenation. ( Huisamen, B; Lochner, A; Upton, J, 2004)
"Systemic hypertension is common in individuals with non-insulin-dependent diabetes (NIDD) and, in this population, markedly increases the risk for cardiovascular complications."1.31NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation. ( Mozaffari, MS; Patel, C; Schaffer, SW; Warren, BK, 2000)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's8 (53.33)18.2507
2000's4 (26.67)29.6817
2010's1 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wu, CS1
Sung, SF1
Tong, SH1
Ong, CT1
Ambrosioni, E1
Hanon, O1
Giacomino, A1
Troy, S1
Bernaud, C1
Girerd, X1
Weber, S1
Huisamen, B1
Upton, J1
Lochner, A1
Jasik, M1
Kasperska-Dworak, A1
Czyzyk, A1
Pasanisi, F1
Imperatore, G1
Vaccaro, O1
Iovine, C1
Ferrara, LA1
Mozaffari, MS1
Patel, C1
Warren, BK1
Schaffer, SW1
Bodansky, HJ1
Maruyama, H1
Saruta, T1
Itoh, H1
Koyama, K1
Kido, K1
Itoh, K1
Takei, I1
Kataoka, K1
Taylor, SH1
Nosadini, R1
Crepaldi, G2
D'Angelo, A2
Feher, MD2
Henderson, AD1
Wadsworth, J1
Poulter, C1
Gelding, S1
Richmond, W1
Sever, PS1
Elkeles, RS1
Castrignano, R1
Pati, T1
Al Awady, M1
Tronca, R1
Levy, P1

Reviews

2 reviews available for prazosin and Diabetes Mellitus, Type 2

ArticleYear
Efficacy of doxazosin in specific hypertensive patient groups.
    American heart journal, 1991, Volume: 121, Issue:1 Pt 2

    Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Cardiomegaly; Diabetes Mellitus, Type 2; Doxazosin

1991
Doxazosin therapy in the treatment of diabetic hypertension.
    American heart journal, 1991, Volume: 121, Issue:4 Pt 2

    Topics: Antihypertensive Agents; Diabetes Mellitus, Type 2; Doxazosin; Humans; Hypertension; Lipids; Lipopro

1991

Trials

4 trials available for prazosin and Diabetes Mellitus, Type 2

ArticleYear
[Management of hypertensive patients with left ventricular hypertrophy].
    Presse medicale (Paris, France : 1983), 2002, Volume: 31 Spec No 2

    Topics: Adrenergic alpha-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent

2002
[Efficacy of and tolerance to prolonged release prazosin in patients with hypertension and non-insulin dependent diabetes].
    Annales de cardiologie et d'angeiologie, 2000, Volume: 49, Issue:7

    Topics: Aged; Antihypertensive Agents; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Diabetic Angi

2000
Effects of a 3-month treatment with terazosin on fasting and postprandial glucose and lipid metabolism in type 2 diabetic patients with hypertension.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 1999, Volume: 9, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Area Under Curve; Blood Glucose; Choleste

1999
Alpha-blocker therapy; a possible advance in the treatment of diabetic hypertension--results of a cross-over study of doxazosin and atenolol monotherapy in hypertensive non-insulin dependent diabetic subjects.
    Journal of human hypertension, 1990, Volume: 4, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aged; Atenolol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Doub

1990

Other Studies

9 other studies available for prazosin and Diabetes Mellitus, Type 2

ArticleYear
Multiple cerebral infarctions related to famotidine-induced eosinophilia.
    Journal of neurology, 2012, Volume: 259, Issue:10

    Topics: Acarbose; Adrenergic alpha-1 Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulc

2012
A role for the alpha1-adrenergic signalling pathway in the response of papillary muscles from type 2 diabetic hearts to anoxia-reoxygenation.
    Cardiovascular drugs and therapy, 2004, Volume: 18, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biomarkers; Blood Glucose; Diabete

2004
Effect of nifedipine, captopril and prazosin on secretory function of pancreatic beta-cells in hypertensive patients with type-2 (non-insulin-dependent) diabetes and in hypertensive non-diabetics.
    Diabetes research and clinical practice, 1996, Volume: 33, Issue:1

    Topics: Adult; Antihypertensive Agents; Blood Glucose; C-Peptide; Calcium Channel Blockers; Captopril; Diabe

1996
NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation.
    American journal of hypertension, 2000, Volume: 13, Issue:5 Pt 1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agon

2000
Doxazosin: alternative antihypertensive treatment.
    Diabetic medicine : a journal of the British Diabetic Association, 1992, Volume: 9, Issue:6

    Topics: Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Doxazosin; Female; Humans; Hyper

1992
Effect of alpha-adrenergic blockade on blood pressure, glucose, and lipid metabolism in hypertensive patients with non-insulin-dependent diabetes mellitus.
    American heart journal, 1991, Volume: 121, Issue:4 Pt 2

    Topics: Adrenergic alpha-Antagonists; Aged; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Drug E

1991
Diabetes mellitus and hypertension: a physiologic basis for a rational therapeutic approach.
    American heart journal, 1991, Volume: 121, Issue:4 Pt 2

    Topics: Antihypertensive Agents; Biological Transport; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2;

1991
A single-blind study of doxazosin in the treatment of mild-to-moderate essential hypertensive patients with concomitant noninsulin-dependent diabetes mellitus.
    American heart journal, 1988, Volume: 116, Issue:6 Pt 2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease

1988
Effects of prazosin on blood pressure and diabetic control in patients with type II diabetes mellitus and mild essential hypertension.
    The American journal of medicine, 1989, Jan-23, Volume: 86, Issue:1B

    Topics: Adult; Aged; Blood Pressure; Diabetes Mellitus, Type 2; Female; Glucose; Heart Rate; Humans; Hyperte

1989