prazosin has been researched along with Depressive Disorder in 5 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic use of TCA drugs increases the expression of alpha(1)-adrenergic receptors (alpha(1)-ARs)." | 1.35 | alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. ( Darsie, B; Doze, VA; Handel, EM; Haselton, JR; Jensen, KA; Luger, EJ; Rorabaugh, BR; Talbot, JN, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doze, VA | 1 |
| Handel, EM | 1 |
| Jensen, KA | 1 |
| Darsie, B | 1 |
| Luger, EJ | 1 |
| Haselton, JR | 1 |
| Talbot, JN | 1 |
| Rorabaugh, BR | 1 |
| Al-Damluji, S | 1 |
| Borsini, F | 1 |
| Nowakowska, E | 1 |
| Samanin, R | 1 |
| Stoudemire, A | 1 |
| Brown, JT | 1 |
| Harris, RT | 1 |
| Blessing-Feussner, C | 1 |
| Roberts, JH | 1 |
| Nichols, JC | 1 |
| Houpt, JL | 1 |
| Menkes, DB | 1 |
1 review available for prazosin and Depressive Disorder
| Article | Year |
|---|---|
The mechanism of action of antidepressants: a unitary hypothesis based on transport-p.
Topics: Adrenergic alpha-Antagonists; Amines; Animals; Antidepressive Agents, Tricyclic; Binding Sites; Biol | 2004 |
1 trial available for prazosin and Depressive Disorder
| Article | Year |
|---|---|
Propranolol and depression: a reevaluation based on a pilot clinical trial.
Topics: Aged; Benzothiadiazines; Clinical Trials as Topic; Depressive Disorder; Diuretics; Female; Humans; M | 1984 |
3 other studies available for prazosin and Depressive Disorder
| Article | Year |
|---|---|
alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.
Topics: Adrenergic alpha-Agonists; Animals; Antidepressive Agents; Behavior, Animal; Brain; Catecholamines; | 2009 |
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidi | 1984 |
Alpha 1-noradrenergic receptor binding in suicide victims.
Topics: Analysis of Variance; Antidepressive Agents; Autoradiography; Depressive Disorder; Humans; Prazosin; | 1991 |