Page last updated: 2024-11-03

prazosin and Cardiomegaly

prazosin has been researched along with Cardiomegaly in 58 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"Sixteen patients with mild or moderate essential hypertension received 1 to 8 mg/day of doxazosin (mean daily dose, 2."9.07Doxazosin in the treatment of mild or moderate essential hypertension: an echocardiographic study. ( Corral, JL; López, NC; Pecorelli, A; Rincón, LA; Terán, VD, 1991)
"A single daily dose of doxazosin taken during a 12-week period produced a significant reduction in blood pressure and left ventricular mass index in patients with mild or moderate hypertension."9.07Echocardiographic assessment of doxazosin on left ventricular mass in patients with essential hypertension. ( Fonseca, R; López, B; Lugo de Franco, V; Medina, O; Monsalve, P; Ostojich, K; Pérez Acuña, F; Torres, N; Vera, O, 1991)
"The stimulus for carbon monoxide-induced cardiac hypertrophy was investigated."7.68Carbon monoxide-induced cardiac hypertrophy is not reduced by alpha- or beta-blockade in the rat. ( Formolo, JM; Penney, DG, 1993)
"There is evidence that cardiac hypertrophy in spontaneously hypertensive rats (SHR) occurs before the development of hypertension."5.28Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension. ( Asano, H; Hashimoto, H; Ishikawa, K; Ito, T; Kondo, J; Okumura, K; Yoshino, M, 1992)
"Although treatment of hypertension per se is important, blood pressure alone may not explain the course of the hypertrophic process."5.28Regression of left ventricular hypertrophy in hypertension. Effects of prazosin therapy. ( Corbett, J; Gonzalez, D; Kaplan, NM; Kulkarni, P; Ram, CV; Sunderajan, P; Taylor, A; Zachariah, NY, 1989)
"Sixteen patients with mild or moderate essential hypertension received 1 to 8 mg/day of doxazosin (mean daily dose, 2."5.07Doxazosin in the treatment of mild or moderate essential hypertension: an echocardiographic study. ( Corral, JL; López, NC; Pecorelli, A; Rincón, LA; Terán, VD, 1991)
"A single daily dose of doxazosin taken during a 12-week period produced a significant reduction in blood pressure and left ventricular mass index in patients with mild or moderate hypertension."5.07Echocardiographic assessment of doxazosin on left ventricular mass in patients with essential hypertension. ( Fonseca, R; López, B; Lugo de Franco, V; Medina, O; Monsalve, P; Ostojich, K; Pérez Acuña, F; Torres, N; Vera, O, 1991)
" Since left ventricular hypertrophy may be an important determinant of outcome in hypertension, the long-term effects of arterial vasodilation with hydralazine on left ventricular mass and function were compared with those of an alternative third-line drug, the alpha1 blocker prazosin, in patients still hypertensive despite combined diuretic and beta blocker therapy."5.06Vasodilators and regression of left ventricular hypertrophy. Hydralazine versus prazosin in hypertensive humans. ( Farkas, RM; Leenen, FH; Marquez-Julio, A; Reeves, RA; Smith, DL, 1987)
" In this article, doxazosin is reviewed for its efficacy in the treatment of severe essential hypertension and specific complications or conditions of mild or moderate essential hypertension, namely, left ventricular hypertrophy, hyperlipidemia, noninsulin-dependent diabetes mellitus, renal insufficiency, pheochromocytoma, chronic obstructive pulmonary disease, peripheral vascular disease, and smoking."4.78Efficacy of doxazosin in specific hypertensive patient groups. ( Taylor, SH, 1991)
" Atenolol neither modified HR nor BP variability in rats with hyperthyroidism."3.70Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism. ( Elghozi, JL; Laude, D; Ponchon, P; Safa-Tisseront, V, 1998)
"The stimulus for carbon monoxide-induced cardiac hypertrophy was investigated."3.68Carbon monoxide-induced cardiac hypertrophy is not reduced by alpha- or beta-blockade in the rat. ( Formolo, JM; Penney, DG, 1993)
"The development of cardiac hypertrophy was examined in rats given ethanol in a nutritionally adequate, liquid diet mixture, by intubation, in severely intoxicating doses at 8-h intervals for up to 96 h, alone or in combination with prazosin."3.67Lack of cardiac alpha 1-adrenoceptor involvement in ethanol-induced cardiac hypertrophy. ( Adams, MA; Hirst, M, 1989)
" On this basis, functional and therapeutical regimen of regression of cardiac hypertrophy (prazosin, clonidine, nifedipine) are analyzed in concentric as well as in excentric hypertrophy in patients with arterial hypertension."3.67[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects]. ( Strauer, BE, 1985)
"Ventricular arrhythmia was a significant independent predictor in V-HeFT II but not in V-HeFT I."2.67Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group. ( Cohn, JN; Fletcher, R; Johnson, GR; Loeb, H; Rector, T; Shabetai, R; Smith, R; Tristani, F, 1993)
"Adenosine has been shown to exert direct antihypertrophic effects on the heart, and plasma adenosine levels have been shown to be elevated in patients with heart failure."1.36Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes. ( Cook, MA; Freeman, DJ; Gan, XT; Karmazyn, M; Pang, T, 2010)
"Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types."1.30Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors. ( Aikawa, R; Hiroi, Y; Komuro, I; Kudoh, S; Mizuno, T; Shiojima, I; Takano, H; Yamazaki, T; Yazaki, Y; Zou, Y, 1997)
"Regression of cardiac hypertrophy occurred after treatment of aortic banded rats with a high dose of enalapril, bunazosin or propranolol, and was accompanied by a reduction in systolic blood pressure."1.29Modulation of adrenergic receptors during regression of cardiac hypertrophy. ( Hata, T; Makino, N; Matsui, H; Nakanishi, H; Yanaga, T; Yano, K, 1994)
" Therefore, after 4 weeks of washout with placebo (phase 1), doxazosin (dosage range from 1 to 16 mg, plus hydrochlorothiazide when necessary) was given to 11 essential hypertensive patients (6 M, 5 F, age range 34-63 years) for 8 weeks (phase 2) in order to achieve diastolic blood pressure values less than 90 mmHg; this dosage was then maintained for a further 20 weeks up to the end of the study (phase 3)."1.28Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin. ( Agabiti-Rosei, E; Beschi, M; Calebich, S; Castellano, M; Muiesan, G; Muiesan, ML; Rizzoni, D; Zulli, R, 1992)
"There is evidence that cardiac hypertrophy in spontaneously hypertensive rats (SHR) occurs before the development of hypertension."1.28Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension. ( Asano, H; Hashimoto, H; Ishikawa, K; Ito, T; Kondo, J; Okumura, K; Yoshino, M, 1992)
"Na+ influx may also be involved in cardiac hypertrophy induced by catecholamine."1.28The role of Na+/H+ exchange in norepinephrine-induced protein synthesis in neonatal cultured rat cardiomyocytes. ( Hori, M; Iwai, K; Iwakura, K; Kagiya, T; Kamada, T; Kitabatake, A; Nakatsubo, N; Sato, H, 1990)
"Although treatment of hypertension per se is important, blood pressure alone may not explain the course of the hypertrophic process."1.28Regression of left ventricular hypertrophy in hypertension. Effects of prazosin therapy. ( Corbett, J; Gonzalez, D; Kaplan, NM; Kulkarni, P; Ram, CV; Sunderajan, P; Taylor, A; Zachariah, NY, 1989)
"Thus, the rapid development of cardiac hypertrophy in the norepinephrine model seems to be directly mediated by stimulation of myocardial alpha- and beta-adrenoceptors rather than by hemodynamic changes."1.28Significance of myocardial alpha- and beta-adrenoceptors in catecholamine-induced cardiac hypertrophy. ( Zierhut, W; Zimmer, HG, 1989)
"In hypertensive cardiac hypertrophy, inotropic responsiveness of alpha and beta adrenergic stimuli is reduced."1.27Excitation-contraction coupling in hypertrophied myocardium. ( Fouad, FM; Hanna, MK; Khairallah, PA; Upsher, ME; Yoshida, K, 1985)
"Even though cardiac hypertrophy is viewed as a beneficial compensatory process that normalizes wall stress, the increased muscle mass carries with it the need of increased blood supply."1.27Effects of vasodilators on the coronary circulation in congestive heart failure. ( Burkart, F; Kiowski, W, 1988)
"Renal hypertrophy was also decreased significantly by cicletanine at a dose of 100 mg/kg."1.27Comparison of cicletanine with other antihypertensive drugs in SHR-SP models. ( Braquet, P; Clostre, F; Le Hegarat, M; Malherbe, E, 1988)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-199030 (51.72)18.7374
1990's22 (37.93)18.2507
2000's4 (6.90)29.6817
2010's2 (3.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pang, T1
Gan, XT1
Freeman, DJ1
Cook, MA1
Karmazyn, M1
Wang, GJ1
Yao, YS1
Wang, HX1
Barron, AJ1
Finn, SG1
Fuller, SJ1
Isabelle, M1
Monteil, C1
Moritz, F1
Dautreaux, B1
Henry, JP1
Richard, V1
Mulder, P1
Thuillez, C1
Lampa, E1
Rossi, F2
Aliperta, A1
Giordano, L1
Perna, D1
Catena, E1
Marmo, E1
Nelson, GI2
Hunyor, SN2
Donnelly, GL2
Simpson, P2
Ruskoaho, H1
Khairallah, PA3
Hanna, MK3
Tarazi, RC1
Upsher, ME2
Yoshida, K3
Bolte, HD1
Bussmann, WD1
Antani, JA1
Harrison, DC1
Feldman, RC1
Ball, RM1
Giudicelli, JF1
Freslon, JL1
Richer, C1
Matsui, H1
Makino, N1
Yano, K1
Nakanishi, H1
Hata, T1
Yanaga, T1
Fregly, MJ1
Sun, Z1
Tümer, N1
Cade, JR1
Hegland, D1
Yürekli, M1
Takahashi, N1
Calderone, A1
Izzo, NJ1
Mäki, TM1
Marsh, JD1
Colucci, WS2
Penney, DG1
Formolo, JM1
Cohn, JN1
Johnson, GR1
Shabetai, R1
Loeb, H1
Tristani, F1
Rector, T1
Smith, R1
Fletcher, R1
Rokosh, DG1
Stewart, AF1
Chang, KC1
Bailey, BA1
Karliner, JS1
Camacho, SA1
Long, CS1
Simpson, PC2
Yamazaki, T1
Komuro, I1
Zou, Y1
Kudoh, S1
Shiojima, I1
Hiroi, Y1
Mizuno, T1
Aikawa, R1
Takano, H1
Yazaki, Y1
Schnabel, P1
Nohr, T1
Nickenig, G1
Paul, M1
Böhm, M1
Gaughan, JP1
Hefner, CA1
Houser, SR1
Grupp, IL1
Lorenz, JN1
Walsh, RA1
Boivin, GP1
Rindt, H1
Safa-Tisseront, V1
Ponchon, P1
Laude, D1
Elghozi, JL1
Hwang, B1
Qu, TY1
Hu, CT1
Chen, HI1
Xiao, L1
Pimental, DR1
Amin, JK1
Singh, K1
Sawyer, DB1
Mier, K1
Kemken, D1
Katus, HA1
Richardt, G1
Kurz, T1
Lloyd, EA1
Agabiti-Rosei, E1
Muiesan, ML1
Rizzoni, D1
Zulli, R1
Calebich, S1
Beschi, M1
Castellano, M1
Muiesan, G1
Leren, P1
Okumura, K1
Kondo, J1
Yoshino, M1
Ishikawa, K1
Asano, H1
Hashimoto, H2
Ito, T1
Taylor, SH1
Corral, JL1
López, NC1
Pecorelli, A1
Rincón, LA1
Terán, VD1
Monsalve, P1
Vera, O1
Pérez Acuña, F1
Medina, O1
Ostojich, K1
López, B1
Torres, N1
Lugo de Franco, V1
Fonseca, R1
Bache, RJ1
Homans, DC1
Dai, XZ1
Yasumoto, K1
Takata, M1
Mikawa, M1
Tomoda, F1
Sasayama, S1
Itaya, T1
Satoh, R1
Uematsu, T1
Nakashima, M1
Hori, M1
Nakatsubo, N1
Kagiya, T1
Iwai, K1
Sato, H1
Iwakura, K1
Kitabatake, A1
Kamada, T1
Fouad, FM1
Sharma, RV1
Butters, CA1
Bhalla, RC1
Motz, W1
Klepzig, M1
Strauer, BE2
Leenen, FH2
Ram, CV1
Gonzalez, D1
Kulkarni, P1
Sunderajan, P1
Corbett, J1
Taylor, A1
Zachariah, NY1
Kaplan, NM1
Adams, MA1
Hirst, M1
Zierhut, W1
Zimmer, HG1
Bishopric, NH1
Ordahl, CP1
Jennings, AA1
Jee, LD1
Smith, JA1
Commerford, PJ1
Opie, LH1
Limas, CJ1
Limas, C1
Rambausek, M1
Ritz, E1
Mall, G1
Mehls, O1
Katus, H1
Smith, DL1
Farkas, RM1
Reeves, RA1
Marquez-Julio, A1
Kiowski, W1
Burkart, F1
Malherbe, E2
Le Hegarat, M2
Clostre, F2
Braquet, P2
Auguet, M1
Delaflotte, S1
Baranes, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795]Phase 430 participants (Actual)Interventional2017-04-10Terminated (stopped due to Funding ended)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for prazosin and Cardiomegaly

ArticleYear
[Treatment of heart failure with vasodilators].
    Der Internist, 1980, Volume: 21, Issue:12

    Topics: Captopril; Cardiomegaly; Cardiotonic Agents; Coronary Disease; Heart Failure; Heart Function Tests;

1980
[Effect of vasodilator agents in chronic heart failure].
    Medizinische Klinik, 1981, Apr-24, Volume: 76, Issue:9

    Topics: Cardiomegaly; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; P

1981
The use of vasodilator agents in the treatment of heart failure.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Nov-10, Volume: 56, Issue:20

    Topics: Cardiac Output; Cardiomegaly; Catheterization; Chronic Disease; Coronary Vessels; Dose-Response Rela

1979
The cardiovascular effects of alpha-receptor blocking agents.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1992, Volume: 10, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cardiomegaly; Cardiovascular System;

1992
Efficacy of doxazosin in specific hypertensive patient groups.
    American heart journal, 1991, Volume: 121, Issue:1 Pt 2

    Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Cardiomegaly; Diabetes Mellitus, Type 2; Doxazosin

1991

Trials

8 trials available for prazosin and Cardiomegaly

ArticleYear
Rest and exercise haemodynamic patterns with chronic prazosin or beta-blocker therapy in hypertensive cardiomegaly.
    The Medical journal of Australia, 1980, 07-26, Volume: 2, Issue:SP1

    Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Female; H

1980
[Effect of vasodilator agents in chronic heart failure].
    Medizinische Klinik, 1981, Apr-24, Volume: 76, Issue:9

    Topics: Cardiomegaly; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; P

1981
[Prazosin in arterial hypertension with cardiac insufficiency].
    Cardiology, 1980, Volume: 66 Suppl 2

    Topics: Adult; Aged; Cardiomegaly; Clinical Trials as Topic; Drug Therapy, Combination; Electrocardiography;

1980
Combined pre- and after-load reduction in hypertensive patients with cardiomegaly and normal filling pressure.
    Clinical science (London, England : 1979), 1981, Volume: 61 Suppl 7

    Topics: Aged; Cardiomegaly; Hemodynamics; Humans; Hypertension; Middle Aged; Physical Exertion; Prazosin; Pr

1981
Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group.
    Circulation, 1993, Volume: 87, Issue:6 Suppl

    Topics: Arrhythmias, Cardiac; Cardiomegaly; Drug Therapy, Combination; Enalapril; Heart Failure; Humans; Hyd

1993
Doxazosin in the treatment of mild or moderate essential hypertension: an echocardiographic study.
    American heart journal, 1991, Volume: 121, Issue:1 Pt 2

    Topics: Adult; Antihypertensive Agents; Cardiomegaly; Doxazosin; Echocardiography; Female; Humans; Hypertens

1991
Echocardiographic assessment of doxazosin on left ventricular mass in patients with essential hypertension.
    American heart journal, 1991, Volume: 121, Issue:1 Pt 2

    Topics: Antihypertensive Agents; Cardiomegaly; Cholesterol; Coronary Disease; Doxazosin; Echocardiography; F

1991
Vasodilators and regression of left ventricular hypertrophy. Hydralazine versus prazosin in hypertensive humans.
    The American journal of medicine, 1987, Volume: 82, Issue:5

    Topics: Adult; Cardiomegaly; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Prazosin; Vasodil

1987

Other Studies

46 other studies available for prazosin and Cardiomegaly

ArticleYear
Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2

    Topics: Adenosine; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Heart V

2010
[Comparing effects of U50488H, prazosin and/or propranolol on cardiac hypertrophy induced by NE in rat].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2010, Volume: 26, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic

2010
Chronic activation of extracellular-signal-regulated protein kinases by phenylephrine is required to elicit a hypertrophic response in cardiac myocytes.
    The Biochemical journal, 2003, Apr-01, Volume: 371, Issue:Pt 1

    Topics: Adrenergic alpha-Antagonists; Animals; Atrial Natriuretic Factor; Benzamides; Butadienes; Cardiomega

2003
Role of alpha1-adrenoreceptors in cocaine-induced NADPH oxidase expression and cardiac dysfunction.
    Cardiovascular research, 2005, Sep-01, Volume: 67, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Cardiomyopathies; Co

2005
A study on the effects of some drugs on DOCA induced hypertension in the rat.
    Experientia, 1980, Feb-15, Volume: 36, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Diuretics; H

1980
Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.
    The Journal of clinical investigation, 1983, Volume: 72, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Cardiomegaly; Isoproterenol; Myocardium; Norepinephrine; Phen

1983
Prevention of cardiac hypertrophy by long-term treatment with isosorbide dinitrate and prazosin but not by minoxidil in spontaneously hypertensive rats.
    Acta pharmacologica et toxicologica, 1984, Volume: 54, Issue:2

    Topics: Animals; Blood Pressure; Cardiomegaly; Female; Hypertension; Isosorbide Dinitrate; Male; Minoxidil;

1984
Biochemical alterations in cardiac hypertrophy.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1984, Volume: 2, Issue:3

    Topics: Animals; Cardiomegaly; Dihydroalprenolol; Hypertension; Myocardium; Prazosin; Protein Kinases; Rats;

1984
[Sustained and beneficial hemodynamic effects of prazosin in cardiac insufficiency].
    Cardiology, 1980, Volume: 66 Suppl 2

    Topics: Blood Pressure; Cardiac Output; Cardiomegaly; Heart Failure; Hemodynamics; Humans; Prazosin; Pulmona

1980
[Antihypertensives and the prevention of development of genetic hypertension in the hypertensive SHR rat].
    Paroi arterielle, 1980, Volume: 6, Issue:4

    Topics: Animals; Antihypertensive Agents; Atenolol; Captopril; Cardiomegaly; Dihydralazine; Dose-Response Re

1980
Modulation of adrenergic receptors during regression of cardiac hypertrophy.
    Journal of hypertension, 1994, Volume: 12, Issue:12

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Iodocyanopindolol; Male; Norepineph

1994
Effect of chronic treatment with prazosin and L-arginine on the elevation of blood pressure during cold exposure.
    Pharmacology, 1994, Volume: 49, Issue:6

    Topics: Adrenal Glands; Angiotensin II; Animals; Arginine; Blood Pressure; Cardiomegaly; Cold Temperature; E

1994
Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes.
    The Journal of clinical investigation, 1994, Volume: 94, Issue:4

    Topics: Animals; Animals, Newborn; Aorta, Abdominal; Atrial Natriuretic Factor; Cardiomegaly; Cells, Culture

1994
Carbon monoxide-induced cardiac hypertrophy is not reduced by alpha- or beta-blockade in the rat.
    Toxicology, 1993, Jun-11, Volume: 80, Issue:2-3

    Topics: Animals; Atenolol; Blood Pressure; Body Weight; Carbon Monoxide; Cardiomegaly; Heart Rate; Lung; Mal

1993
Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. Repression of alpha1B and alpha1D but induction of alpha1C.
    The Journal of biological chemistry, 1996, Mar-08, Volume: 271, Issue:10

    Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Endothelins; Ge

1996
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
    Circulation, 1997, Mar-04, Volume: 95, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-1 Receptor Antagonists; Amino Acids; Animals; Animals,

1997
Alpha-adrenergic signal transduction in renin transgenic rats.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 30, Issue:6

    Topics: Animals; Animals, Genetically Modified; Cardiomegaly; Cell Membrane; GTP-Binding Proteins; Mice; Myo

1997
Electrophysiological properties of neonatal rat ventricular myocytes with alpha1-adrenergic-induced hypertrophy.
    The American journal of physiology, 1998, Volume: 275, Issue:2

    Topics: Action Potentials; Adrenergic alpha-1 Receptor Agonists; Analysis of Variance; Animals; Animals, New

1998
Overexpression of alpha1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Blood Pressure; Calcium; Cardiomegaly; Cells, Cult

1998
Autonomic contribution to the blood pressure and heart rate variability changes in early experimental hyperthyroidism.
    Journal of hypertension, 1998, Volume: 16, Issue:12 Pt 2

    Topics: Animals; Atenolol; Atropine; Autonomic Nervous System; Blood Pressure; Cardiomegaly; Disease Models,

1998
Hemodynamic and neurohumoral changes after abdominal aortic constriction in rats.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1999, Volume: 23, Issue:4

    Topics: Animals; Aorta, Abdominal; Captopril; Cardiac Output; Cardiomegaly; Catecholamines; Constriction; El

1999
MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes.
    Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Cells, Cultured; Enzy

2001
Adrenergic activation of cardiac phospholipase D: role of alpha(1)-adrenoceptor subtypes.
    Cardiovascular research, 2002, Volume: 54, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Clonidine; Dioxane

2002
Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin.
    Journal of human hypertension, 1992, Volume: 6, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adult; Aldosterone; Antihypertensive Agents; Blood Pressure; Cardiomeg

1992
Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension.
    Molecular and cellular biochemistry, 1992, May-13, Volume: 112, Issue:1

    Topics: Animals; Body Weight; Cardiomegaly; Diglycerides; Enalapril; Heart Ventricles; Hypertension; Lipids;

1992
Adrenergic vasoconstriction limits coronary blood flow during exercise in hypertrophied left ventricle.
    The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 2

    Topics: Animals; Cardiomegaly; Coronary Circulation; Dogs; Heart Ventricles; Hemodynamics; Myocardium; Oxyge

1991
Reversal of left ventricular hypertrophy by terazosin in hypertensive patients.
    Journal of human hypertension, 1990, Volume: 4, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aged; Cardiomegaly; Drug Evaluation; Electrocardiography; Female; Hear

1990
Increases in alpha-but not beta-adrenoceptors in hypertrophied non-infarcted cardiac muscles from rats with chronic myocardial infarction.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:4

    Topics: Animals; Body Weight; Cardiomegaly; Coronary Vessels; Dihydroalprenolol; Male; Muscle Proteins; Myoc

1990
The role of Na+/H+ exchange in norepinephrine-induced protein synthesis in neonatal cultured rat cardiomyocytes.
    Japanese circulation journal, 1990, Volume: 54, Issue:5

    Topics: Amiloride; Analysis of Variance; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Ion Excha

1990
Excitation-contraction coupling in hypertrophied myocardium.
    Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 6

    Topics: Age Factors; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Epinephrine; Heart; Hypertension

1985
Alterations in the plasma membrane properties of the myocardium of spontaneously hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:7

    Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Cell Membrane; Ion Channels; Male; Myocardium; Nif

1986
Regression of cardiac hypertrophy: experimental and clinical results.
    Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 6

    Topics: Animals; Cardiomegaly; Clonidine; Enalapril; Humans; Hypertension; Nifedipine; Prazosin; Rats; Rats,

1987
Left ventricular hypertrophy in hypertensive patients.
    The American journal of medicine, 1989, Jan-23, Volume: 86, Issue:1B

    Topics: Cardiomegaly; Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Prazosin

1989
Regression of left ventricular hypertrophy in hypertension. Effects of prazosin therapy.
    The American journal of medicine, 1989, Jan-23, Volume: 86, Issue:1B

    Topics: Blood Pressure; Cardiomegaly; Echocardiography; Female; Heart; Humans; Hypertension; Male; Middle Ag

1989
Lack of cardiac alpha 1-adrenoceptor involvement in ethanol-induced cardiac hypertrophy.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:3

    Topics: Adrenal Glands; Animals; Behavior, Animal; Body Weight; Cardiomegaly; Catecholamines; Ethanol; Male;

1989
Significance of myocardial alpha- and beta-adrenoceptors in catecholamine-induced cardiac hypertrophy.
    Circulation research, 1989, Volume: 65, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; DNA; Female; Myoca

1989
Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:4

    Topics: Actins; Animals; Cardiomegaly; Cells, Cultured; Dose-Response Relationship, Drug; Isoproterenol; Myo

1987
Acute effect of nifedipine on blood pressure and left ventricular ejection fraction in severely hypertensive outpatients: predictive effects of acute therapy and prolonged efficacy when added to existing therapy.
    American heart journal, 1986, Volume: 111, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Cardiomegaly; Drug Therapy, Combination; F

1986
Altered intracellular adrenoceptor distribution in myocardium of spontaneously hypertensive rats.
    The American journal of physiology, 1987, Volume: 253, Issue:4 Pt 2

    Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cell Membrane; Cytosol; Dihydroalprenolol; Hyperten

1987
Myocardial hypertrophy in rats with renal insufficiency.
    Kidney international, 1985, Volume: 28, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Blood Transfusion; Calcium; Cardiomegaly; Hydral

1985
[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects].
    Zeitschrift fur Kardiologie, 1985, Volume: 74 Suppl 7

    Topics: Blood Pressure; Cardiac Volume; Cardiomegaly; Cardiomyopathy, Hypertrophic; Clonidine; Coronary Circ

1985
Effects of vasodilators on the coronary circulation in congestive heart failure.
    The American journal of cardiology, 1988, Sep-09, Volume: 62, Issue:8

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Cardiomegaly; Cilazapri

1988
Comparison of cicletanine with other antihypertensive drugs in SHR-SP models.
    Drugs under experimental and clinical research, 1988, Volume: 14, Issue:2-3

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Diuresis; Di

1988
Antihypertensive profile of cicletanine, a furopyridine derivative: comparison with captopril, indapamide and prazosin.
    Pharmacological research communications, 1988, Volume: 20 Suppl 3

    Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Captopril; Cardiomegaly; Diuresis; Diuretic

1988
Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.
    Circulation research, 1985, Volume: 56, Issue:6

    Topics: Animals; Ascorbic Acid; Cardiomegaly; Cell Division; Cells, Cultured; Cycloheximide; Dopamine; Heart

1985
Alterations of myocardial alpha 1-adrenergic receptors in hypertensive cardiac hypertrophy in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 283, Issue:1

    Topics: Aging; Animals; Blood Pressure; Cardiomegaly; Hypertension; Hypertension, Renal; Male; Myocardium; O

1986