prazosin has been researched along with Brain Injuries in 14 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha1-NA antagonist, or propranolol (PROP), a beta-NA antagonist, would continue to reinstate hemiplegia over time after recovery from weight-drop traumatic brain injury (TBI)." | 5.31 | Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury. ( Feeney, DM; Stibick, DL, 2001) |
| " Nine weeks after providing sleep counseling and initiating an increasing dosage schedule of prazosin at bedtime, 65 veterans reported restful sleep." | 1.35 | Improving sleep: initial headache treatment in OIF/OEF veterans with blast-induced mild traumatic brain injury. ( Ruff, RL; Ruff, SS; Wang, XF, 2009) |
| " This study used a within-subject, dose-response design to determine whether prazosin (PRAZ), an alpha1-NA antagonist, or propranolol (PROP), a beta-NA antagonist, would continue to reinstate hemiplegia over time after recovery from weight-drop traumatic brain injury (TBI)." | 1.31 | Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury. ( Feeney, DM; Stibick, DL, 2001) |
| "Amphetamine-treated animals displayed no significant improvement in beam-walking ability either during or after drug intoxication (from days 3 to 5 after brain injury)." | 1.30 | Lack of delayed effects of amphetamine, methoxamine, and prazosin (adrenergic drugs) on behavioral outcome after lateral fluid percussion brain injury in the rat. ( Dhillon, HS; Dose, JM; Kraemer, PJ; Maki, A; Prasad, RM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruff, RL | 2 |
| Riechers, RG | 1 |
| Wang, XF | 2 |
| Piero, T | 1 |
| Ruff, SS | 2 |
| Visanji, NP | 1 |
| Fox, SH | 1 |
| Johnston, TH | 1 |
| Millan, MJ | 1 |
| Brotchie, JM | 1 |
| Kobori, N | 1 |
| Hu, B | 1 |
| Dash, PK | 1 |
| Friedrich, MJ | 1 |
| Shibata, M | 1 |
| Einhaus, S | 1 |
| Schweitzer, JB | 1 |
| Zuckerman, S | 1 |
| Leffler, CW | 1 |
| Schraufnagel, DE | 1 |
| Thakkar, MB | 1 |
| Dunn-Meynell, AA | 1 |
| Yarlagadda, Y | 1 |
| Levin, BE | 1 |
| Dose, JM | 1 |
| Dhillon, HS | 1 |
| Maki, A | 1 |
| Kraemer, PJ | 1 |
| Prasad, RM | 1 |
| Stibick, DL | 1 |
| Feeney, DM | 1 |
| Prasad, MR | 1 |
| Tzigaret, CM | 1 |
| Smith, D | 1 |
| Soares, H | 1 |
| McIntosh, TK | 1 |
| Pappius, HM | 3 |
| Inoue, M | 1 |
| McHugh, M | 1 |
1 review available for prazosin and Brain Injuries
| Article | Year |
|---|---|
Neurochemical approaches to the amelioration of brain injury.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Brain Injuries; Deoxyglucose; Dibenzocycloheptenes; Di | 1990 |
13 other studies available for prazosin and Brain Injuries
| Article | Year |
|---|---|
For veterans with mild traumatic brain injury, improved posttraumatic stress disorder severity and sleep correlated with symptomatic improvement.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Brain Injuries; Directive Counseling; Dyssomnias; Fe | 2012 |
Alpha1-adrenoceptors mediate dihydroxyphenylalanine-induced activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaques.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic alpha-Antagonists; Animals; Benserazide; Br | 2009 |
Improving sleep: initial headache treatment in OIF/OEF veterans with blast-induced mild traumatic brain injury.
Topics: Adrenergic alpha-Antagonists; Adult; Blast Injuries; Brain Injuries; Cohort Studies; Counseling; Dys | 2009 |
Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Brain Injuries; Disease Models, Animal; Epinephrin | 2011 |
Researchers seek new ways to counter the harmful toll of stress on the brain.
Topics: Antihypertensive Agents; Brain Injuries; Catecholamines; Guanfacine; Humans; Prazosin; Prefrontal Co | 2013 |
Cerebral blood flow decreased by adrenergic stimulation of cerebral vessels in anesthetized newborn pigs with traumatic brain injury.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Arterioles; Blood Pressure; Brain Injuries; | 1993 |
Pulmonary venous sphincter constriction is attenuated by alpha-adrenergic antagonism.
Topics: Animals; Brain Injuries; Corrosion Casting; Craniocerebral Trauma; Female; Lymphatic System; Male; M | 1993 |
Alpha 1-adrenoceptor blockade increases behavioral deficits in traumatic brain injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; | 1997 |
Lack of delayed effects of amphetamine, methoxamine, and prazosin (adrenergic drugs) on behavioral outcome after lateral fluid percussion brain injury in the rat.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Injuries; Male; Methoxamine; Prazosin; Rats; Rats, Spr | 1997 |
Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; | 2001 |
Decreased alpha 1-adrenergic receptors after experimental brain injury.
Topics: Animals; Brain Injuries; Cerebral Cortex; Hippocampus; In Vitro Techniques; Kinetics; Male; Membrane | 1992 |
The effect of alpha-adrenergic receptor blockers prazosin and yohimbine on cerebral metabolism and biogenic amine content of traumatized brain.
Topics: Animals; Biogenic Amines; Brain; Brain Injuries; Cerebral Cortex; Functional Laterality; Glucose; Hy | 1991 |
Significance of biogenic amines in functional disturbances resulting from brain injury.
Topics: Animals; Biogenic Amines; Brain Injuries; Cerebral Cortex; Fenclonine; Freezing; Glucose; Male; Praz | 1988 |