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prazosin and Bradyarrhythmia

prazosin has been researched along with Bradyarrhythmia in 22 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Research Excerpts

ExcerptRelevanceReference
" After pretreatment with a beta-blocker, atenolol, stimulation of PFA suppressed phenylephrine (50 microg/kg iv)-induced bradycardia (DeltaHR=-360+/-29 beats/min without PFA stimulation vs."3.73Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice. ( Fukuda, Y; Kuwaki, T; Sakurai, T; Zhang, W, 2006)
"Blockade of alpha(1)-adrenoreceptors with prazosin produces bradycardia."3.71Age-related peculiarities of the effect of alpha-adrenoreceptor blockade on cardiac function in rats. ( Zefirov, AL; Zefirov, TL; Ziyatdinova, NI, 2002)
"Vasodepressor reactions, characterized by paradoxic bradycardia, were induced in rats when the inferior vena cava was occluded during an infusion of isoproterenol."3.69Paradoxic bradycardia (vasodepressor reaction) induced by inferior vena cava occlusion: the role of alpha- and beta-adrenergic receptors and their interaction. ( Asta, JA; Cameron, DA; Waxman, MB, 1994)
"The ectoparasiticide amitraz stimulates alpha 2-adrenoceptors to produce side-effects such as bradycardia and hypotension."3.69Amitraz depresses cardiovascular responses to bilateral carotid occlusion. ( Cullen, LK; Reynoldson, JA, 1996)
" The selective 5-HT2 antagonist LY 53857 abolished the increase in MAP and the bradycardia elicited by 5-HT."3.68Vasopressin and autonomic mechanisms mediate cardiovascular actions of central serotonin. ( Alper, RH; Pérgola, PE, 1991)
"Yohimbine (100 micrograms/kg), an alpha 2-adrenoceptor blocking agent when injected into the vertebral artery of anaesthetized dogs decreased the vagally mediated bradycardia induced by carotid sinus nerve stimulation."3.66Role of alpha 1- and alpha 2-adrenoceptors in the modulation of the baroreflex vagal bradycardia. ( Chelly, J; Huchet, AM; Schmitt, H, 1981)
"Pretreatment with methyllycaconitine citrate, a selective alpha7 nicotinic receptor antagonist, significantly attenuated cytisine-induced sympathetic response with little effect on the parasympathetic response."1.36Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. ( Freeling, J; Lacroix, C; Li, YF, 2010)
"Prazosin treatment did reduced the inhibition, but only moderately."1.29A prejunctional mechanism in midbrain periaqueductal gray inhibition of vagal bradycardia in rats. ( Inui, K; Murase, S; Murata, K; Nosaka, S, 1996)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19905 (22.73)18.7374
1990's7 (31.82)18.2507
2000's8 (36.36)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Braga, VA1
Burmeister, MA1
Sharma, RV1
Davisson, RL1
Li, YF1
Lacroix, C1
Freeling, J1
Tjen-A-Looi, SC1
Hsiao, AF1
Longhurst, JC1
Ziyatdinova, NI1
Zefirov, AL1
Zefirov, TL1
Sandblom, E1
Axelsson, M1
Zhang, W1
Sakurai, T1
Fukuda, Y1
Kuwaki, T1
Perry, SF1
Desforges, PR1
Seak, CJ1
Lin, CC1
Huchet, AM1
Chelly, J1
Schmitt, H1
Roquebert, J1
Demichel, P1
Malek, A1
Waeber, B1
Nussberger, J1
Brunner, HR1
Kobrin, I1
Stessman, J1
Yagil, Y1
Ben-Ishay, D1
Buchholz, RA1
Nathan, MA1
Waxman, MB1
Asta, JA1
Cameron, DA1
Bawaskar, HS1
Bawaskar, PH1
Ball, J1
Nosaka, S1
Inui, K1
Murase, S1
Murata, K1
Reynoldson, JA1
Cullen, LK1
Roach , D1
Thakore , E1
Sheldon , R1
Zou, CJ1
Wang, H1
Ge, L1
Sundaram, K1
Murugaian, J1
Sapru, H1
Pérgola, PE1
Alper, RH1

Trials

1 trial available for prazosin and Bradyarrhythmia

ArticleYear
Vasodilators: scorpion envenoming and the heart (an Indian experience).
    Toxicon : official journal of the International Society on Toxinology, 1994, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Bradycardia; Cardiovascular Diseases; Child; Ch

1994

Other Studies

21 other studies available for prazosin and Bradyarrhythmia

ArticleYear
Cardiovascular responses to peripheral chemoreflex activation and comparison of different methods to evaluate baroreflex gain in conscious mice using telemetry.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:4

    Topics: Animals; Atropine; Baroreflex; Blood Pressure; Bradycardia; Cardiovascular Physiological Phenomena;

2008
Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
    Autonomic neuroscience : basic & clinical, 2010, Apr-19, Volume: 154, Issue:1-2

    Topics: Aconitine; Adrenergic alpha-Antagonists; Alkaloids; Analysis of Variance; Animals; Atropine; Azocine

2010
Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:3

    Topics: Acidosis; Adrenergic alpha-1 Receptor Antagonists; Anesthetics; Animals; Atenolol; Atropine Derivati

2011
Age-related peculiarities of the effect of alpha-adrenoreceptor blockade on cardiac function in rats.
    Bulletin of experimental biology and medicine, 2002, Volume: 133, Issue:6

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Bradycardia; Electric Stimulation; Heart Rate; Prazosi

2002
Effects of hypoxia on the venous circulation in rainbow trout (Oncorhynchus mykiss).
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2005, Volume: 140, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Cardiac Output; Central Venous Pressure; Female;

2005
Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:6

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Ataxin-3; Atenolol; Baroreflex;

2006
Does bradycardia or hypertension enhance gas transfer in rainbow trout (Oncorhynchus mykiss)?
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2006, Volume: 144, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Bradycardia; Branchial Region; Carb

2006
Acute intoxication with terazosin.
    The American journal of emergency medicine, 2008, Volume: 26, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aged; Bradycardia; Drug Overdose; Electrocardiography; Humans; Male; P

2008
Role of alpha 1- and alpha 2-adrenoceptors in the modulation of the baroreflex vagal bradycardia.
    European journal of pharmacology, 1981, May-22, Volume: 71, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Dogs; Female; Male; Phenylephrine; Prazosin; Pre

1981
Effects of thymoxamine and its metabolites on clonidine-induced hypotension and bradycardia in rats.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 258, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Bradycardia; Clonidine; Heart Rate; Hypotension; Male; Moxisyly

1982
Blood pressure dependency on vasopressin and angiotensin II in prazosin-treated conscious normotensive rats.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 225, Issue:2

    Topics: Angiotensin II; Animals; Arginine Vasopressin; Blood Pressure; Bradycardia; Catecholamines; Deamino

1983
Prazosin-induced bradycardia in acute treatment of hypertension.
    Archives of internal medicine, 1983, Volume: 143, Issue:10

    Topics: Adult; Aged; Blood Pressure; Bradycardia; Female; Heart Rate; Humans; Hypertension; Male; Middle Age

1983
Chronic lability of the arterial blood pressure produced by electrolytic lesions of the nucleus tractus solitarii in the rat.
    Circulation research, 1984, Volume: 54, Issue:3

    Topics: Animals; Atropine; Behavior, Animal; Blood Pressure; Bradycardia; Electrolysis; Heart Rate; Male; Me

1984
Paradoxic bradycardia (vasodepressor reaction) induced by inferior vena cava occlusion: the role of alpha- and beta-adrenergic receptors and their interaction.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:11

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Re

1994
Symptomatic sinus bradycardia due to prazosin.
    Lancet (London, England), 1994, Jan-08, Volume: 343, Issue:8889

    Topics: Bradycardia; Humans; Male; Middle Aged; Prazosin; Syncope

1994
A prejunctional mechanism in midbrain periaqueductal gray inhibition of vagal bradycardia in rats.
    The American journal of physiology, 1996, Volume: 270, Issue:2 Pt 2

    Topics: Acetylcholine; Animals; Baroreflex; Bradycardia; Electric Stimulation; Male; Mesencephalon; Neural I

1996
Amitraz depresses cardiovascular responses to bilateral carotid occlusion.
    Journal of veterinary pharmacology and therapeutics, 1996, Volume: 19, Issue:1

    Topics: Animals; Baroreflex; Blood Pressure; Bradycardia; Carotid Arteries; Carotid Stenosis; Dogs; Dose-Res

1996
Origins of heart rate variability: autonomic blockade of large magnitude, transient bradycardia in conscious rabbits.
    The Canadian journal of cardiology, 2001, Volume: 17, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-2 Receptor An

2001
The central mechanism of the depressor-bradycardia effect of "Tinggong.
    Acupuncture & electro-therapeutics research, 2000, Volume: 25, Issue:3-4

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bradycardia; Cardiovascular Syst

2000
Microinjections of norepinephrine into the intermediolateral cell column of the spinal cord exert excitatory as well as inhibitory effects on the cardiac function.
    Brain research, 1991, Mar-29, Volume: 544, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Dioxanes; Heart; Heart Rate; Idazoxan; Male; Mic

1991
Vasopressin and autonomic mechanisms mediate cardiovascular actions of central serotonin.
    The American journal of physiology, 1991, Volume: 260, Issue:6 Pt 2

    Topics: Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Chlorisondamine; Ergolines; Heart Ra

1991