prazosin has been researched along with Blood Pressure, High in 1096 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prazosin is an orally active post-synaptic selective alpha 1-adrenoreceptor antagonist that has been widely used in treating hypertension and congestive heart failure (CHF)." | 10.15 | Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure. ( Brogden, RN; Kellerman, D; Romankiewicz, JA; Stanaszek, WF, 1983) |
| "Terazosin, a new selective long-acting alpha1-adrenergic blocking agent, has been shown to be an effective once-daily antihypertensive agent in four of five randomized double-blind placebo-controlled studies of patients with mild to moderate hypertension." | 10.15 | Terazosin: a new alpha 1-blocker for the treatment of hypertension: a review of randomized, controlled clinical trials of once-daily administration as monotherapy. ( Glassman, HN; Horton, JK; Jordan, DC; Luther, RR; Sperzel, WD; Steinberg, FJ, 1986) |
| "The present study aims to assess and compare the effects of carvedilol and terazosin plus enalapril on lower urinary tract symptoms (LUTS), the urine flow, and blood pressure (BP) in patients with moderate hypertension (HTN) and benign prostatic hyperplasia (BPH)." | 9.41 | A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia. ( DalirAkbari, N; Farshi, A; Khalili, M; Mahmoudinezhad, M; Zomorrodi, A, 2021) |
| "This prospective randomized double-blinded clinical trial was designed to explore the effects of amlodipine and the combination of amlodipine with terazosin in improving postvoid residual (PVR) in patients with lower urinary tract symptoms (LUTS) and concomitant hypertension." | 9.14 | [Amlodipine combined with terazosin reduces postvoid residual and the risk of acute urinary retention]. ( Fang, J; Li, YL; Liu, HP; Qin, XH; Xu, XP; Yang, C; Zhang, X, 2009) |
| "We determined the efficacy and safety of a relatively high dose of terazosin (5mg) in Korean patients with lower urinary tract symptoms (LUTS), with or without concomitant hypertension." | 9.12 | High-dose terazosin therapy (5mg) in Korean patients with lower urinary tract symptoms with or without concomitant hypertension: a prospective, open-label study. ( Ku, JH; Kwak, C; Lee, JK, 2007) |
| "The aim of this study was to evaluate the effectiveness and the safety of prazosin osmotic tablet treatment in non-insulin-dependent diabetic patients with mild to moderate arterial hypertension." | 9.09 | [Efficacy of and tolerance to prolonged release prazosin in patients with hypertension and non-insulin dependent diabetes]. ( Bernaud, C; Giacomino, A; Girerd, X; Hanon, O; Troy, S; Weber, S, 2000) |
| "To review and assess the cardiovascular safety of the alpha1-blocker terazosin when used to treat symptomatic benign prostatic hyperplasia (BPH) in patients taking concurrent antihypertensive medications." | 9.09 | Effects of terazosin therapy on blood pressure in men with benign prostatic hyperplasia concurrently treated with other antihypertensive medications. ( Lowe, FC; Olson, PJ; Padley, RJ, 1999) |
| "The effects of the alpha-1-adrenergic blocker terazosin on blood pressure and fasting and postprandial glucose and lipid metabolism were assessed in type 2 diabetic patients with hypertension." | 9.09 | Effects of a 3-month treatment with terazosin on fasting and postprandial glucose and lipid metabolism in type 2 diabetic patients with hypertension. ( Ferrara, LA; Imperatore, G; Iovine, C; Pasanisi, F; Vaccaro, O, 1999) |
| "To determine whether nifedipine or prazosin is the more appropriate second-line antihypertensive agent in pregnancy." | 9.09 | Nifedipine or prazosin as a second agent to control early severe hypertension in pregnancy: a randomised controlled trial. ( Hall, DR; Odendaal, HJ; Smith, M; Steyn, DW, 2000) |
| "To determine the effects of terazosin on blood pressure and on antihypertensive therapy when used in managing benign prostatic hyperplasia (BPH)." | 9.08 | Terazosin in benign prostatic hyperplasia: effects on blood pressure in normotensive and hypertensive men. ( Kirby, RS, 1998) |
| "A double-blind, double-dummy, parallel-group trial that used a predominantly Hispanic patient population with mild-to-moderate hypertension was designed to compare the efficacy, safety, and acceptability of monotherapy with either transdermal clonidine applied once a week or terazosin tablets taken once a day." | 9.08 | Alpha 2-agonist versus alpha 1-antagonist in mild-to-moderate hypertension: comparison of transdermal clonidine and terazosin monotherapies. ( Alvarez, C; Harris, SI, 1997) |
| "This study reviews and assesses the safety of terazosin for the treatment of symptomatic benign prostatic hyperplasia (BPH)." | 9.07 | Safety assessment of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia: a combined analysis. ( Lowe, FC, 1994) |
| "Terazosin is safe and effective in treating concomitant hypertension and BPH." | 9.07 | Terazosin in the treatment of hypertension and symptomatic benign prostatic hyperplasia: a primary care trial. ( Guthrie, R, 1994) |
| "The antihypertensive efficacy of single-drug therapy with nifedipine (N), prazosin (P), or acebutolol (A) and the influence of these agents on coronary risk factors including hypoglycemia, hyperuricemia, and hyperlipidemia, were studied in adolescents with hypertension." | 9.07 | [Evaluation of the efficacy and tolerance of three antihypertensive agents used as single-drug therapy, nifedipine, prazosin and acebutolol in severe, idiopathic hypertension in adolescents]. ( Cichocka, E; Januszewicz, P; Wyszynska, T, 1993) |
| "The effects of six weeks of treatment with the selective peripheral alpha 1-adrenoceptor blocker terazosin, or the selective beta 1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were compared in a single-blind, randomized, crossover study of 17 patients with mild-to-moderate essential hypertension." | 9.07 | A comparison of the effects of the selective peripheral alpha 1-blocker terazosin with the selective beta 1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension. ( Cleland, J; Coles, SJ; Humphreys, J; Ligueros, M; Unwin, R; Wilkins, MR, 1992) |
| "Terazosin is a selective alpha 1-adrenoceptor antagonist; its actions on the serum lipoprotein profile were compared with those of the cardioselective beta-adrenoceptor antagonist atenolol in 40 patients with mild to moderate hypertension." | 9.07 | Comparison of antihypertensive and lipid actions of terazosin and atenolol in essential hypertension. ( Guy, S; Humphreys, JE; Silke, B, 1992) |
| "When doxazosin was given to patients with hypertension not adequately controlled by beta-blockade, blood pressure was normalized in 94% of the 34 patients (blood pressure less than or equal to 140/85 mm Hg)." | 9.07 | The addition of doxazosin to the treatment regimen of patients with hypertension not adequately controlled by beta-blockers. ( Barlage, U; Englert, RG, 1991) |
| "The safety, efficacy and the effect on the plasma total cholesterol of once-daily terazosin hydrochloride administered as monotherapy was evaluated in 69 patients with mild-moderate untreated essential hypertension in this open, hospital, multi-centre, 3 month study." | 9.07 | A multicentre, hospital study of the efficacy and safety of terazosin and its effects on the plasma cholesterol levels of patients with untreated essential hypertension. ( Coles, S; Lytle, T; Waite, MA, 1991) |
| "The safety, efficacy and the effect on the plasma total cholesterol of once-daily terazosin hydrochloride administered either as monotherapy or in combination with other antihypertensive therapy were evaluated in patients with mild-moderate uncontrolled essential hypertension in this U." | 9.07 | A multicentre, hospital study of the efficacy and safety of terazosin and its effects on the plasma cholesterol levels of patients with essential hypertension. ( Coles, SJ; Lytle, TB; Waite, MA, 1991) |
| "This Latin American study assessed in the general practice setting the efficacy and tolerance of once-daily doxazosin in the treatment of mild or moderate essential hypertension (sitting diastolic blood pressure, 95 to 115 mm Hg)." | 9.07 | Doxazosin in the treatment of essential hypertension in general medical practice in Latin America. ( Fonseca, R; Marshall, D; Silva, H, 1991) |
| "This study was designed to assess the efficacy and tolerance of doxazosin in patients with mild, moderate, or severe essential hypertension in a general practice setting." | 9.07 | A multicenter study of doxazosin in the treatment of essential hypertension in France. ( Bonnet, G, 1991) |
| "This study assessed the long-term (54 weeks) antihypertensive efficacy and safety of doxazosin in the treatment of mild or moderate essential hypertension, defined as sitting and standing diastolic blood pressure of 95 to 114 mm Hg." | 9.07 | A long-term study of doxazosin in the treatment of mild or moderate essential hypertension in general medical practice. ( Manos, J, 1991) |
| "Sixteen patients with mild or moderate essential hypertension received 1 to 8 mg/day of doxazosin (mean daily dose, 2." | 9.07 | Doxazosin in the treatment of mild or moderate essential hypertension: an echocardiographic study. ( Corral, JL; López, NC; Pecorelli, A; Rincón, LA; Terán, VD, 1991) |
| "A single daily dose of doxazosin taken during a 12-week period produced a significant reduction in blood pressure and left ventricular mass index in patients with mild or moderate hypertension." | 9.07 | Echocardiographic assessment of doxazosin on left ventricular mass in patients with essential hypertension. ( Fonseca, R; López, B; Lugo de Franco, V; Medina, O; Monsalve, P; Ostojich, K; Pérez Acuña, F; Torres, N; Vera, O, 1991) |
| " Forty-two patients, ages 42 to 65 years, including 21 men with sustained hypertension and elevated serum cholesterol levels, were included in a trial of monotherapy with doxazosin administered once daily (range, 1 to 16 mg)." | 9.07 | Efficacy and safety of doxazosin in the treatment of patients with mild or moderate essential hypertension and elevated levels of cholesterol. ( Taylor, SH, 1991) |
| "This study assessed the efficacy and safety of once-daily doxazosin in the treatment of patients (n = 19) with mild or moderate essential hypertension (sitting diastolic blood pressure [DBP] 95 to 114 mm Hg) and concomitant intermittent claudication (Doppler ankle/arm ratio of less than 0." | 9.07 | A multicenter study of doxazosin in the treatment of patients with mild or moderate essential hypertension and concomitant intermittent claudication. ( Catalano, M; Libretti, A, 1991) |
| "Doxazosin (mean dose 11 mg) given once daily in combination with 100 mg atenolol (n = 44) was compared with placebo and atenolol (n = 43) in a double-blind, multicenter study in patients with mild to moderate essential hypertension." | 9.06 | Doxazosin in combination with atenolol in essential hypertension: a double-blind placebo-controlled multicentre trial. ( Christensen, CC; Dathan, R; Dean, S; Searle, M; Westheim, A, 1990) |
| "The efficacy and tolerability of doxazosin and atenolol in the management of mild and moderate hypertension were compared in a multicentre, parallel study, the first year of which was randomized and double-blind." | 9.06 | A long-term study of atenolol and doxazosin in mild and moderate hypertension. ( Daae, L; Talseth, T; Westlie, L, 1990) |
| "The paper deals with the study into the benefits of prazosin and trasicor used in arterial hypertension." | 9.06 | [Changes in lipid fractions of blood during the treatment of hypertension with prazosin and trasicor]. ( Damiĭonaĭtene, RA; Kuchinskene, ZZ; Rugenius, IuIu; Steponenene, RV; Vidugiris, AI, 1990) |
| "Guanfacine, an alpha 2 adrenoceptor agonist, was compared with prazosin hydrochloride for the treatment of patients with mild to moderate essential hypertension in an 8-week, double-blind, randomized, parallel evaluation to determine efficacy and safety." | 9.06 | Antihypertensive efficacy of guanfacine and prazosin in patients with mild to moderate essential hypertension. ( Alderman, MH; Lewin, A; Mathur, P, 1990) |
| "The antihypertensive effect and the influence on lipid metabolism of the alpha-receptor blocking drugs indoramin and prazosin given in combination with hydrochlorothiazide were investigated in patients with mild to moderate essential hypertension." | 9.06 | Comparison of the effect of indoramin and prazosin on blood pressure and lipid profiles in essential hypertension. ( Overlack, A; Stumpe, KO, 1986) |
| "Twenty-three patients with essential hypertension were treated consecutively with prazosin or dihydrochlorothiazide or the combination of the two, each treatment period lasting for three months." | 9.06 | Prazosin improves atherogenic index and inhibits the deleterious effect of dihydrochlorothiazide in patients with essential hypertension. ( Balás-Eltes, A; Farsang, C; Fehér, J; Péter, M, 1987) |
| "The antihypertensive effect and safety of doxazosin once-daily was compared with that of atenolol once-daily in 40 patients with mild to moderate hypertension." | 9.06 | Short-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension. ( Amery, A; Fagard, R; Lijnen, P; Staessen, J, 1988) |
| "The antihypertensive effect and safety of doxazosin once daily as well as the effect on serum lipids was compared with that of atenolol once daily in 40 patients with mild to moderate hypertension." | 9.06 | Long-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension. ( Amery, A; Fagard, R; Lijnen, P; Lissens, W; Staessen, J, 1989) |
| "In an acute, double-blind, crossover study on 12 patients with essential hypertension, the interaction between nifedipine and prazosin was investigated in the supine position." | 9.06 | Nifedipine-prazosin interaction in patients with essential hypertension. ( Farsang, C; Kiss, I, 1989) |
| "The haemodynamic effect of one-week prazosin therapy was investigated in 21 patients with essential hypertension (9 of WHO stage I, 12 of stage II)." | 9.06 | Haemodynamic effect of prazosin during hyperosmolar mannitol load in essential hypertension. ( Ondrejka, P; Pechán, J; Veres, I, 1989) |
| "The effects of once-daily therapy with doxazosin (1 to 8 mg/day) on exercise capacity, left ventricular performance and hemodynamics (radionuclide ventriculography) were compared with those of atenolol (50 to 100 mg/day) and placebo in a randomized, double-blind crossover trial in 16 patients (9 men) with mild hypertension." | 9.06 | Comparison of doxazosin and atenolol in mild hypertension, and effects on exercise capacity, hemodynamics and left ventricular function. ( Bautovich, GJ; Fletcher, PJ; Gillin, AG; Horvath, JS; Hutton, BF; Tiller, DJ, 1989) |
| " This study investigates aspects of the pharmacokinetics, pharmacodynamics and concentration-effect relationships in 10 patients with essential hypertension during acute and chronic treatment with doxazosin, an alpha 1-adrenoceptor antagonist." | 9.06 | Concentration-effect relationships and individual responses to doxazosin in essential hypertension. ( Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL, 1989) |
| "In a single-blind, crossover study, prazosin and enalapril monotherapies were evaluated in 15 patients, aged 55 years or older (average age, 64 years), with mild hypertension (sitting diastolic blood pressure between 90 and 104 mm Hg)." | 9.06 | Mild hypertension in the elderly. A comparison of prazosin and enalapril. ( Cheung, DG; Hoffman, CA; Ricci, ST; Weber, MA, 1989) |
| "The results of a comparative study of the action of a new Soviet agent prazosin in arterial hypertension patients have shown that it does not differ in its pharmacokinetic characteristics from its Finnish analogue and is an effective hypotensive agent." | 9.06 | [Effectiveness of the Russian drug prazosin in patients with arterial hypertension (Working Group for the Cooperative Study of New Drugs in the Prevention of Arterial Hypertension (CSDPAH)]. ( , 1989) |
| "The safety and efficacy of once-daily terazosin as monotherapy were evaluated in five randomized, double-blind, placebo-controlled studies in which 351 patients with mild to moderate hypertension participated." | 9.06 | Terazosin: an effective once-daily monotherapy for the treatment of hypertension. ( Dauer, AD, 1986) |
| "The effect of withdrawal of terazosin therapy in patients with mild to moderate hypertension was assessed in two double-blind, placebo-controlled studies." | 9.06 | Effect of withdrawal of terazosin therapy in patients with hypertension. ( Ruoff, G, 1986) |
| "In a multicenter, double-blind, placebo-controlled study, the efficacy and safety of terazosin and prazosin were compared in patients with mild to moderate essential hypertension." | 9.06 | Comparison of the safety and efficacy of once-daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension. ( Deger, G, 1986) |
| "The long-term safety, efficacy and effect on serum lipid profile of doxazosin, a new alpha 1-adrenoceptor inhibitor administered once daily, were compared with those of prazosin, administered twice daily, in 104 patients with essential hypertension treated for 1 year." | 9.06 | An open one-year comparison of doxazosin and prazosin for mild to moderate essential hypertension. ( Madsbu, HP; Torvik, D, 1987) |
| "9 mg, range 1 to 16) in the treatment of essential hypertension were compared in a double-blind study with those of hydrochlorothiazide (HCTZ) (mean dosage, 84." | 9.06 | Comparative effects of doxazosin and hydrochlorothiazide on serum lipids and blood pressure in essential hypertension. ( Claessens, J; Nelemans, F; Riesen, W; Streulens, Y; Trost, BN; Weidmann, P, 1987) |
| "Chronic responses of systemic hemodynamics and blood pressure counterregulatory ("pseudo-tolerance") mechanisms were investigated in matched groups of patients with essential hypertension after 1 month of vasodilator therapy with pinacidil (a direct arterial dilator), prazosin (an alpha 1-adrenergic blocking drug) or captopril (an angiotensin-converting enzyme inhibitor)." | 9.06 | Chronic effects of direct vasodilation (pinacidil), alpha-adrenergic blockade (prazosin) and angiotensin-converting enzyme inhibition (captopril) in systemic hypertension. ( Izzo, JL; Kallay, MC; Larrabee, PS; Licht, MR; Radke, KJ; Smith, RJ, 1987) |
| "The efficacy and tolerability of felodipine and prazosin were compared in a double-blind randomised parallel group study of 100 patients with moderately severe essential hypertension, treated concomitantly with a beta-blocking drug." | 9.06 | Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study. ( Anderson, A; Gibson, J; Jackson, B; Morgan, TO, 1987) |
| "The long-term treatment of essential hypertension with terazosin, a new once-a-day alpha 1-adrenergic blocking agent, was evaluated in 364 hypertensive patients who received total daily doses of 1 to 40 mg for 3 weeks to 56 months." | 9.06 | Terazosin, a new selective alpha 1-adrenergic blocking agent. Results of long-term treatment in patients with essential hypertension. ( Estep, CB; Glassman, HN; Horton, JK; Jordan, DC; Luther, RR; Schmitz, PJ, 1988) |
| "The effects of prazosin therapy were recently evaluated in ambulatory patients with essential hypertension and chronic obstructive pulmonary disease." | 9.06 | Prazosin in hypertensive patients with chronic bronchitis and asthma: a brief report. ( Chodosh, S; Pizzuto, D; Tuck, J, 1989) |
| "A 12-week double-blind study was performed to compare the safety and efficacy of doxazosin, prazosin and placebo in 172 patients with essential hypertension." | 9.06 | Multicentre 12-week double-blind comparison of doxazosin, prazosin and placebo in patients with mild to moderate essential hypertension. ( Madsbu, HP; Torvik, D, 1986) |
| "The safety and antihypertensive efficacy of PN 200-110 (isradipine), a novel calcium antagonist, are discussed in a preliminary report of double-blind, multicenter, controlled, phase III clinical trials for essential hypertension." | 9.06 | Treatment of essential hypertension with PN 200-110 (isradipine). ( Hamilton, BP, 1987) |
| "The efficacy and safety of doxazosin (DOX) for the treatment of hypertension was investigated." | 9.06 | Effect of doxazosin monotherapy on blood pressure and plasma lipids in patients with essential hypertension. ( Bloomfield, R; Cubeddu, LX; Halperin, A; Klotman, PE; Nelson, EB; Pickering, BI; Pool, JL; Wombolt, DG, 1988) |
| "A multicentre double-blind comparative study of urapidil and prazosin was performed in 412 outpatients with mild to moderate essential hypertension." | 9.06 | Double-blind comparison of urapidil and prazosin in the treatment of patients with essential hypertension. ( Kaneko, Y, 1988) |
| "The safety and efficacy of once-daily terazosin hydrochloride administered concomitantly with once-daily atenolol for the treatment of essential hypertension were evaluated in this double-blind, multiclinic, placebo-controlled study." | 9.06 | Concomitant administration of terazosin and atenolol for the treatment of essential hypertension. ( Holtzman, JL; Kaihlanen, PM; Lewin, AJ; Oberlin, JA; Rider, JA; Spindler, JS, 1988) |
| " In nine patients with essential hypertension, following single and multiple doses of ketanserin, assessments were made of blood pressure and heart rate, QT interval, and pressor responses to phenylephrine and angiotensin II." | 9.06 | Acute and chronic ketanserin in essential hypertension: antihypertensive mechanisms and pharmacokinetics. ( Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL, 1987) |
| "Patients with essential hypertension were randomized to treatment with either prazosin or pinacidil, a new direct-acting vasodilator." | 9.06 | Comparative effects of pinacidil and prazosin on blood pressure, weight, plasma volume, the renin-angiotensin-aldosterone system, and the renal kallikrein-kinin system in patients with essential hypertension. ( Solomon, RJ; Weinberg, MS, 1987) |
| "The effects of prazosin and atenolol monotherapy on plasma lipid concentrations were compared in 51 patients with mild to moderate essential hypertension." | 9.06 | Effects of prazosin, atenolol, and thiazide diuretic on plasma lipids in patients with essential hypertension. ( Lowenstein, J; Neusy, AJ, 1986) |
| "Clinical trials of the alpha-adreno-blocker prazosin (Pratsiol as produced by "Orion", Finland) were carried out in 42 patients with essential hypertension, stages 2-3 by WHO classification, and 3 patients with nephrogenic hypertension." | 9.06 | [Use of prazosin in patients with hypertension]. ( Gorbacheva, ON; Kharchenko, VI; Liusov, VA; Mart'ianova, II; Mikhaĭlusova, MP, 1986) |
| "The clinical effect of the peripheral vasodilator prazosin (Adwersuten, GDR) was studied in 51 patients with second-stage essential hypertension." | 9.06 | [Analysis of hypotensive and hemodynamic effects of prazosin in patients with hypertension]. ( Dobrotvorskaia, TE; Ostapiuk, FE; Samofanova, MS; Shengeliia, RG, 1986) |
| "A randomized, parallel group study evaluated the safety, efficacy, and effect of the alpha blocking agent prazosin and the angiotensin converting enzyme inhibitor captopril on serum lipid levels in patients with mild to moderate hypertension." | 9.06 | Prazosin versus captopril as initial therapy. Effect on hypertension and lipid levels. ( Kraut, J; Okun, R, 1987) |
| "We report the results of an observer blind crossover trial in 31 patients with essential hypertension comparing the hypotensive effect of four doses of prazosin and of hydralazine used as the third step of triple therapy and additional data on the efficacy of low dose combinations of these two drugs." | 9.05 | Hydralazine and prazosin in the treatment of hypertension. ( Barnes, JN; Drew, PJ; Sharman, VL; Vandenburg, MJ; Wright, P, 1983) |
| "The acute and chronic effects of fixed dosages of clonidine and prazosin on supine and upright blood pressure, the renin-angiotensin-aldosterone system, and plasma catecholamines were compared in 24 patients with essential hypertension." | 9.05 | Comparative antihypertensive and endocrinologic effects of clonidine and prazosin in patients with essential hypertension. ( Drayer, JI; Hubbell, FA; Rose, DE; Weber, MA, 1984) |
| "The effects of prazosin and propranolol on total serum cholesterol concentration, low-density lipoprotein and high-density lipoprotein cholesterol fractions, and serum triglyceride concentration were compared in a crossover study in 29 patients with mild to moderate essential hypertension." | 9.05 | Effects of prazosin and propranolol on serum lipids in patients with essential hypertension. ( Lowenstein, J; Neusy, AJ, 1984) |
| "Prazosin was compared with hydralazine in 39 patients (mean age 49 years), who were already on beta-blockade for arterial hypertension." | 9.05 | Peripheral vasodilatation in the treatment of hypertension. Prazosin compared with hydralazine in patients not responding to beta-receptor blockade. ( Fagerberg, SE; Frithz, G; Malmberg, L, 1982) |
| "48 patients with normal-renin essential hypertension were treated with prazosin alone or in combination with oxprenolol." | 9.05 | Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension. ( Farsang, C; Juhász, I; Kapocsi, J; Székács, B; Vajda, L, 1981) |
| "Changes in blood pressure, plasma volume (PV) (125I-albumin space), extracellular volume (ECV) (82Br-space) and glomerular filtration rate (GFR) (51Cr-EDTA clearance) were measured in 12 patients with mild to moderate essential hypertension on placebo and during long-term treatment with prazosin." | 9.05 | The antihypertensive effect of prazosin on mild to moderate hypertension, changes in plasma volume, extracellular volume and glomerular filtration rate. ( McNair, A; Nielsen, PE; Rasmussen, K; Rasmussen, S, 1980) |
| "The treatments of mild hypertension with atenolol and prazosin in occupationally active men and women were compared in a double blind cross-over with placebo." | 9.05 | Working ability and exercise tolerance during treatment of mild hypertension. II. A comparison between atenolol and prazosin medication. ( Green, KA; Lange Andersen, K; Ottmann, W; Piatkowski, W, 1985) |
| "After screening two local populations in the northern part of The Netherlands for hypertension, patients with a diastolic pressure (DP) between 95 and 120 mmHg were treated daily either with 50 mg hydrochlorothiazide or 100 mg atenolol." | 9.05 | A comparison of labetalol and prazosin combined with atenolol in non-responders to atenolol plus hydrochlorothiazide in uncomplicated hypertension. ( Donker, AJ; May, JF; Schuurman, FH; ten Berge, BS; van der Veur, E; Wesseling, H, 1985) |
| "Prazosin hydrochloride, a new antihypertensive agent, is said to be of mild-to-moderate potency when used as a sole agent in mild-to-moderate hypertension and when used in conjunction with other agents in severe hypertension." | 9.04 | Prazosin-new hypertensive agent. A double-blind crossover study in the treatment of hypertension. ( Schirger, A; Sheps, SG, 1977) |
| "Prazosin (Minipress; Pfizer), a new antihypertensive agent, was investigated in 24 outpatients with uncontrolled hypertension." | 9.04 | Prazosin in the therapy of uncontrolled hypertension. ( Lubbe, WF, 1977) |
| "The efficacy of prazosin was assessed in 21 patients with essential hypertension who failed to respond adequately to a combination of methyldopa and hydrochlorothiazide." | 9.04 | Prazosin in hypertension with and without methyldopa. ( Itskovitz, HD; Kochar, MS; Zeller, JR, 1979) |
| "Prazosin, an orally active alpha-1 selective adrenergic antagonist, has been of value in treating patients with hypertension and congestive heart failure." | 8.76 | Alpha-adrenergic receptor blockade with prazosin. Consideration of hypertension, heart failure, and potential new applications. ( Colucci, WS, 1982) |
| "Terazosin was effective in lowering blood pressure when administered alone (in dosages of 1 to 80 mg/day) and when prescribed (in dosages of 1 to 20 mg/day) in combination with other antihypertensive agents." | 7.77 | The safety and efficacy of terazosin in the treatment of essential hypertension in blacks. ( Saunders, E, 1991) |
| "Terazosin is a post-synaptic alpha 1-adrenoceptor antagonist with a similar pharmacodynamic profile to prazosin." | 7.76 | Terazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in essential hypertension. ( Monk, JP; Titmarsh, S, 1987) |
| "Doxazosin is a long-acting selective alpha 1-adrenoceptor antagonist structurally related to prazosin." | 7.76 | Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension. ( Brogden, RN; Young, RA, 1988) |
| " In these studies, we produced chronic NO blockade by oral administration of the NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME), which produced sustained hypertension and increased renal vascular resistance (RVR) in conscious rats." | 7.69 | Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension. ( Baylis, C; Engels, K; Qiu, C, 1994) |
| " The objective of this study was to examine short-term effects of cilazapril and prazosin therapy on insulin sensitivity assessed by a 15' test of insulin tolerance of obese hypertensive persons." | 7.69 | [The effect of cilazapril and prazosin on insulin sensitivity in patients with essential hypertension]. ( Cirić, J; Nesović, M; Tasić, N; Trbojević, B; Zarković, M, 1995) |
| "The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP > or = 115 mmHg)." | 7.69 | Oral therapy with combined enalapril, prazosin and hydrochlorothiazide in the acute treatment of severe hypertension in Nigerians. ( Adigun, AQ; Afolabi, MA; Ajayi, AA; Ajayi, OE; Akintomide, AO; Balogun, MO, 1996) |
| "Eighteen previously untreated primary hypertension patients were selected for therapy either with 50-250 mg/day metoprolol (n = 11) or with 3-20 mg/day prazosin (n = 8)." | 7.69 | Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension. ( Gretzer, I; Hjemdahl, P, 1997) |
| "The effect of enalapril and terazosin on serum lipid profile was investigated in 36 patients with primary hypertension and hypercholesterolemia (total cholesterol 5." | 7.68 | [Effect of enalapril and terazosin on lipid metabolism in patients with essential arterial hypertension and accompanying hypercholesterolemia]. ( Hańczycowa, H; Jordanek, P; Jurga, M; Ponikowski, P; Rotter, A; Sebzda, T; Spring, A, 1993) |
| "Prazosin is a selective peripheral alpha 1-adrenoceptor antagonist used in the treatment of hypertension and heart failure." | 7.68 | [Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases]. ( Bourget, P; Edouard, D; Fernandez, H; Frydman, R; Ribou, F, 1993) |
| "Secretion of insulin, glucagon, gastrin and pancreatic polypeptide (PP) at basal and test meal stimulation conditions were investigated in 17 patients with essential hypertension (EH) before and after 12 months of treatment with prazosin and in 10 healthy subjects." | 7.68 | [Effect of long term prazosin treatment on secretion of insulin, glucagon, gastrin, and pancreatic polypeptide in patients with essential hypertension]. ( Grzeszczak, W; Kokot, F; Wiecek, A; Zukowska-Szczechowska, E, 1993) |
| "The influence of prazosin treatment for 12 months on basal and LH-RH stimulated FSH, LH, estradiol and testosterone secretion and basal and chlorpromazine stimulated prolactin secretion was estimated in 15 male patients with essential hypertension." | 7.68 | [The effect of long-term prazosin treatment on plasma follitropin (FSH), lutropin (LH), prolactin, estradiol and testosterone concentration in male patients with essential hypertension]. ( Kokot, F; Wiecek, A; Zukowska-Szczechowska, E, 1993) |
| "Doxazosin, an alpha-adrenergic antagonist with potentially favourable effects on lipid status was evaluated in 25 otherwise healthy general practice patients with mild to moderate hypertension." | 7.68 | Combined effect of doxazosin and pindolol on blood pressure control and lipid concentrations in patients with essential hypertension selected from general practice. Hunter Hypertension Research Group. ( , 1992) |
| "Oral prazosin hydrochloride (2-20 mg/day) was administered to 38 patients with chronic congestive heart failure due to ischemic heart disease for 6-18 months." | 7.68 | Prazosin in chronic congestive heart failure due to ischemic heart disease. ( Antani, JA; Antani, NJ; Nanivadekar, AS, 1991) |
| "During three consecutive days of prazosin treatment in a patient with pheochromocytoma, urinary catecholamine metabolite levels were correlated with plasma renin activity." | 7.68 | Prazosin's effect in high renin hypertension complicating pheochromocytoma. ( Mager, A; Rechavia, E; Sagie, A; Sclarovsky, S; Strasberg, B, 1991) |
| "The antihypertensive effects of the selective alpha 1-adrenoceptor antagonist, terazosin, in black patients with uncomplicated, mild to moderate essential hypertension were examined retrospectively in seven randomized, double-blind, placebo-controlled trials conducted in the United States." | 7.68 | Efficacy of terazosin in the treatment of essential hypertension in blacks. ( Achari, R; Glassman, HN; Klepper, MJ; Laddu, AR; Luther, RR; Maurath, CJ, 1990) |
| "The effect of prazosin treatment on blood pressure, plasma HDL-cholesterol concentration, and apoprotein-AI/HDL (apoAI/HDL) kinetics was studied in 11 patients with mild hypertension." | 7.68 | Effect of prazosin treatment on HDL kinetics in patients with hypertension. ( Chen, YD; Hoffman, BB; Reaven, GM; Sheu, WH; Swislocki, AL, 1990) |
| " The pharmacokinetics of doxazosin, following a single oral dose (1 mg) and chronic oral dosing (doubling doses up to a maximum of 16 mg day-1), were studied in 18 patients with mild to moderate hypertension and stable renal function varying from normal to severely impaired." | 7.68 | The pharmacokinetics of doxazosin in patients with hypertension and renal impairment. ( Dewhurst, AG; Honeywell, R; Oliver, RM; Renwick, AG; Upward, JW; Waller, DG, 1990) |
| " Therefore, a study was designed to compare the efficacy and the effects on left ventricular function of hydrochlorothiazide, propranolol and prazosin in 13 patients with mild to moderate hypertension." | 7.67 | Monotherapy in mild to moderate hypertension: comparison of hydrochlorothiazide, propranolol and prazosin. ( Benowitz, N; Inouye, I; Loge, D; Massie, B; Simpson, P; Topic, N, 1984) |
| "The selective alpha1-adrenergic antagonist prazosin has recently been recommended for the preoperative management of pheochromocytoma, but we have observed a hypertensive crisis in a patient with such a tumor, despite prazosin therapy." | 7.67 | Hypertensive crisis in prazosin-treated pheochromocytoma. ( Fitzgerald, GA; Knapp, HR, 1984) |
| "A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension." | 7.67 | Antihypertensive effects and pharmacokinetics of single and consecutive administration of doxazosin in patients with mild to moderate essential hypertension. ( Kaneko, Y; Miyajima, E; Miyakawa, T; Shionoiri, H; Takagi, N; Umemura, S; Yasuda, G; Yoshimura, H, 1987) |
| "Thirteen patients with essential hypertension were treated with an alpha 1-adrenoceptor antagonist, terazosin (1 to 4 mg/day) for 12 months." | 7.67 | Hemodynamic and endocrinological effects of a new selective alpha 1-blocking agent, terazosin, in patients with essential hypertension. Results of long-term treatment. ( Mikawa, M; Sasayama, S; Takata, M; Tomoda, F; Yasumoto, K; Yoshida, K, 1989) |
| "This study evaluated the effect of prazosin in controlled mild hypertension and evaluated select metabolic changes that occurred with prazosin monotherapy." | 7.67 | Effect of prazosin treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. ( Chen, YD; Hoffman, BB; Reaven, GM; Sheu, WH; Swislocki, AL, 1989) |
| " This hypertension was managed with either prazosin (n = 29) or nifedipine (n = 17)." | 7.67 | Cyclosporine-associated hypertension in cardiopulmonary transplantation. The beneficial effect of nifedipine on renal function. ( Bateman, DN; Dark, JH; Kirk, AJ; Omar, I, 1989) |
| "Two hundred twenty-six patients with mild to moderate hypertension were treated with terazosin in an open, multicenter study to determine the drug's long-term efficacy and safety." | 7.67 | Long-term experience with terazosin for treatment of mild to moderate hypertension. ( Mersey, JH, 1986) |
| "Doxazosin, a selective alpha 1-inhibitor, was assessed in 34 patients with mild and moderate hypertension." | 7.67 | Doxazosin in the treatment of mild and moderate essential hypertension in general medical practice. ( van den Hogen, AL, 1988) |
| "Although the pathology of essential hypertension is still unclear, studies have shown that doxazosin, a selective alpha 1-inhibitor, is able to effectively control mild-to-moderate hypertension." | 7.67 | Control of coronary heart disease risk factors with doxazosin as monotherapy and in combination therapy. ( Rosenthal, J, 1988) |
| "The effects of selective alpha 1-adrenergic blockade with the agent terazosin on blood pressure and cardiovascular pressor responsiveness as related to major pressor factors were assessed in 17 patients with mild to moderate essential hypertension (mean age +/- s." | 7.67 | Cardiovascular effects of short-term selective alpha 1-adrenergic blockade with terazosin in patients with essential hypertension. ( Beretta-Piccoli, C; Ferrier, C; Weidmann, P, 1985) |
| "The effects of prazosin treatment on blood pressure and diabetic control were assessed in 22 patients with stable non-insulin-dependent diabetes mellitus and hypertension." | 7.67 | Effects of prazosin on blood pressure and diabetic control in patients with type II diabetes mellitus and mild essential hypertension. ( Levy, P, 1989) |
| "The acute and chronic haemodynamic effects of doxazosin were studied in 14 patients (10 males, four females) with essential hypertension, at rest supine and sitting and during 100 W bicycling exercise." | 7.67 | Acute and chronic haemodynamic effects of doxazosin in hypertension at rest and during exercise. ( Haugland, H; Lund-Johansen, P; Omvik, P, 1986) |
| "Arterial blood pressure and central hemodynamic changes were assessed in 44 patients with essential hypertension, uncontrollable by prazosin alone, after propranolol (anaprilin), celiprolol, clonidine (clofelin) or verapamil were added to the treatment schedule." | 7.67 | [Hemodynamic effect of a combination of prazosin with cardiac depressants in the treatment of hypertension]. ( Akopian, LM; Basem, AS; Ivleva, AIa; Krasnobaeva, GM; Moiseev, VS, 1988) |
| "As both hormonal and hemodynamic alterations similar to those occurring during exercise can also be produced in humans by hypoglycemia, the present study explored changes in hemodynamic parameters during hypoglycemia and the effects of the alpha 1-adrenergic blocker, prazosin, on those responses in hypertensive patients." | 7.67 | Vasodepressor effects of prazosin during insulin-induced hypoglycemia in hypertensive patients. ( Ijichi, H; Iyoda, I; Ochiai, M; Takahashi, H; Watanabe, T, 1985) |
| "The aim of this study was to determine whether insulin sensitivity measured by the euglycaemic insulin clamp technique is lower in patients with primary hypertension than in matched healthy control subjects, and whether this sensitivity was affected after 12 weeks of antihypertensive treatment with the alpha 1-adrenoceptor blocking drug prazosin." | 7.67 | Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension. ( Berne, C; Lithell, H; Pollare, T; Selinus, I, 1988) |
| "In an open, non-comparative study, the effect of Prazosin, a selective and competitive inhibitor of alpha-adrenergic receptors, on blood pressure and lipid metabolism was studied in out-patients with hypertension." | 7.67 | [Prazosin in the treatment of hypertension: effect on lipid metabolism]. ( Dietz, S; Egger, H; Hariri, K; Hitzenberger, G; Kittler, E; Neumann, K; Niedrist, W; Nitsch-Fritz, R; Ravanelli, O; Sapinsky, H, 1987) |
| "Changes in plasma active and inactive renin and angiotensin II in response to tilt and intravenous frusemide were assessed in ten patients with essential hypertension, before treatment and again during chronic therapy with the alpha 1-adrenoceptor antagonist prazosin." | 7.67 | The effect of chronic prazosin therapy on the response of the renin-angiotensin system in patients with essential hypertension. ( Fulton, JD; Leckie, BJ; Malatino, LS; McAreavey, D; Morton, JJ; Murray, GD; Robertson, JI; Webb, DJ, 1987) |
| "Therapeutic efficiency and hemodynamic effects of prazosin were examined in 42 patients with essential hypertension in the course of prolonged treatment." | 7.67 | [Long-term use of prazosin alone and combined with propranolol in patients with essential hypertension]. ( D'iakonova, EG; Erina, EV; Prokopova, TN, 1986) |
| "The relative bioavailability of two different Prazosine preparations (Adversuten, VEB Arzneimittelwerk Dresden, GDR and Minipress, Pfizer GmbH, Karlsruhe, FRG) has been determined in 10 patients suffering from an essential hypertension by the cross-over test following a single oral application." | 7.67 | [Comparative study of the relative bioavailabilities of two prazosin preparations in patients with essential hypertension]. ( Faulhaber, HD; Günzel, R; Homuth, V; Prehm, C; Rostock, G; Unger, P, 1985) |
| "To elucidate the mechanism of action of prazosin in lowering the blood pressure, we studied the vascular pressor responsiveness to the infusion of norepinephrine and angiotensin II before and after prazosin in patients with essential hypertension." | 7.66 | Alpha adrenergic blockade by prazosin in therapy of essential hypertension. ( Anderson, RJ; Crumpler, CP; Hart, GR; Ram, CV, 1981) |
| "The combination of prazosin (3-21 mg/day) and oxprenolol (60-360 mg/day) was used to treat 25 pregnant women with severe essential hypertension and 19 women with the hypertension-oedema-proteinuria syndrome." | 7.66 | Combined alpha- and beta-adrenoceptor antagonism with prazosin and oxprenolol in control of severe hypertension in pregnancy. ( Hodge, JV; Lubbe, WF, 1981) |
| "Combined use of prazosin and beta-blockers in a hypertension clinic over a 3-year period was surveyed by means of a computerized record system." | 7.66 | Combined use of prazosin and beta-blockers in hypertension. ( Frost, GW; Jeremy, D; Lewis, RG; Mitchell, AS; Raftos, J; Stokes, GS; Thornell, IR, 1982) |
| "Patients with essential hypertension (n = 45) had significantly lower substance P plasma levels (13." | 7.66 | Evidence of decreased plasma substance P levels in human essential hypertension and influence of prazosin treatment. ( Faulhaber, HD; Görne, RC; Hartrodt, W; Homuth, V; Naumann, E; Oehme, P; Pfeiffer, D; Rathsack, R; Rostock, G, 1983) |
| "The disposition and effect of orally administered prazosin have been studied in eight women with hypertension which was uncontrolled by beta-adrenoceptor blockade during the last trimester of pregnancy." | 7.66 | Clinical pharmacological studies with prazosin during pregnancy complicated by hypertension. ( Butters, L; Low, RA; Reid, JL; Rubin, PC, 1983) |
| "Prazosin (Minipress; Pfizer), the first purely alpha-blocking antihypertensive agent, was used to treat 22 pregnant patients with moderately severe hypertension (diastolic blood pressure persistently above 95 mmHg at gestational ages ranging from 18 to 33 weeks)." | 7.66 | Prazosin and oxprenolol therapy in pregnancy hypertension. ( Davey, DA; Dommisse, J; Roos, PJ, 1983) |
| "Combined use of prazosin and propranolol was effective in preoperative management of three patients with norepinephrine(NE)-secreting pheochromocytoma (PHEO)." | 7.66 | Prazosin and propranolol in preoperative management of pheochromocytoma. ( Cubeddu, LX; Rosales, CB; Zarate, NA; Zschaeck, DW, 1982) |
| "An open study was undertaken in 31 patients with moderate to severe hypertension to compare labetalol (a competitive antagonist of both alpha-adrenoreceptors and beta-adrenoreceptors) alone and in combination with a thiazide diuretic, with a combination of thiazide, beta-adrenergic blocking agent and the alpha-adrenoreceptor blocker prazosin." | 7.66 | Use of labetalol in moderate to severe hypertension. ( Hua, AS; Kincaid-Smith, P; Macdonald, I; Thomas, GW; Whitworth, JA; Woo, KT, 1980) |
| "A case of angina pectoris worsened by prazosin is presented." | 7.66 | Exacerbation of angina pectoris by prazosin. ( Charness, ME; Fishman, JA; Robertson, D, 1979) |
| "In fifteen patients with hypertension, inadequately controlled during treatment with propranolol alone (mean dosage 333 mg/day), plasma volume (PV) and extracellular fluid volume (ECV) were determined." | 7.66 | Changes in plasma volume and extracellular fluid volume after addition of prazosin to propranolol treatment in patients with hypertension. ( Ibsen, H; Jensen, HA; Leth, A; Rasmussen, K, 1978) |
| "In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6 to 8 mg/day for 19 days before surgery." | 7.66 | Prazosin in the diagnosis and treatment of pheochromocytoma. ( Gill, DP; Wallace, JM, 1978) |
| "In a study of 10 patients suffering from hypertension the results showed that combination treatment with prazosin, cyclopenthiazide and a beta-blocker produced a significant fall in blood pressure." | 7.65 | Prazosin combined with thiazide diuretic and beta-blocker in the treatment of hypertension. ( Bhoola, R; Seedat, MA; Seedat, YK, 1977) |
| "We conducted an uncontrolled study of the efficacy of prazosin in the treatment of hypertension in 45 patients." | 7.65 | Prazosin alone and combined with a thiazide diuretic in the treatment of hypertension. ( Bhoola, R; Seedat, MA; Seedat, YK, 1977) |
| "The clinical usefulness of prazosin was investigated in 67 patients with mild to moderate essential hypertension for 6 to 12 weeks." | 7.65 | Open studies with prazosin in the treatment of essential hypertension. Prazosin Research Group in Japan. ( , 1977) |
| "Prazosin was used as an additional antihypertensive agent for treating 16 patients with hypertension and significant renal functional impairment." | 7.65 | Prazosin in the treatment of patients with hypertension and renal functional impairment. ( Bailey, RR; Little, PJ; Lynn, KL; Neale, TL, 1976) |
| "Terazosin is a selective alpha1-adrenoceptor antagonist." | 6.69 | Effects of oral and intravenous terazosin and head-up tilt on blood pressure responses in patients with hypertension. ( Achari, R; Baroldi, P; Cavanaugh, J; Cohen, A; Hosmane, B; Linnen, P, 1998) |
| "Treatment with prazosin GITS did not produce any statistically or clinically significant change in the metabolic parameters at the end of 24 weeks, while with nifedipine SR there was a significant increase in the serum LDL values at 24 weeks (p = 0." | 6.69 | Prazosin GITS vs sustained release nifedipine in patients with hypertension and abnormal lipid profile: a randomized, controlled, multicenter study. Madras Hypertension Study Group. ( Joglekar, SJ; Misra, KP; Mukherjee, S; Nanivadekar, AS, 1998) |
| "Treatment with prazosin GITS resulted in a favourable effect on the serum lipid profile at the end of 24 weeks (p = 0." | 6.69 | Prazosin GITS vs atenolol in patients with hypertension and normal lipid profile: a randomized, controlled multicenter study. Hyderabad Hypertension Study Group. ( Jaguste, V; Joglekar, SJ; Nanivadekar, AS, 1998) |
| "Treatment with prazosin GITS resulted in a favourable effect on serum triglycerides at the end of 8 weeks (p = 0." | 6.69 | A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group. ( Joglekar, SJ; Nanivadekar, AS, 1998) |
| "alpha-Blockers and calcium antagonists are commonly used in the treatment of hypertension, but few data are available concerning first dose or steady state (SS) hemodynamic and pharmacokinetic effects of these drugs when they are used in combination therapy." | 6.68 | Combined terazosin and verapamil therapy in essential hypertension. Hemodynamic and pharmacokinetic interactions. ( Johnston, W; Laddu, AR; Lenz, ML; Pool, JL; Taylor, AA; Varghese, A, 1995) |
| " Terazosin, an alpha 1-adrenergic blocking agent, was given initially at the dosage of 1 mg daily." | 6.68 | Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension. ( Angeli-Greaves, M; Armas Padilla, MC; Armas-Hernández, MJ; Carvajal, AR; Guerrero Pajuelo, J; Hernández Hernández, R, 1996) |
| "Both doxazosin and prazosin were well tolerated; seven patients (5." | 6.67 | A double-blind comparative study of doxazosin and prazosin in the treatment of essential hypertension. ( Fukiyama, K; Iimura, O; Ijichi, H; Inagaki, Y; Ishii, M; Kaneko, Y; Omae, T; Yagi, S; Yamada, K; Yoshinaga, K, 1991) |
| "Enalapril was increased to 10, 20 and 40 mg during the last 4 weeks, and prazosin was respectively increased to 4, 10 and 20 mg." | 6.67 | [The effect of enalapril and prazosin on mild to moderate hypertension in black South Africans]. ( Muntingh, GL; Venter, CP; Venter, HL, 1991) |
| "Doxazosin therapy was associated with opposite patterns of changes in fasting glucose, lipids and lipoproteins but only for serum triglyceride was difference between treatments significant." | 6.67 | Alpha-blocker therapy; a possible advance in the treatment of diabetic hypertension--results of a cross-over study of doxazosin and atenolol monotherapy in hypertensive non-insulin dependent diabetic subjects. ( Elkeles, RS; Feher, MD; Gelding, S; Henderson, AD; Poulter, C; Richmond, W; Sever, PS; Wadsworth, J, 1990) |
| "With doxazosin treatment, the mean supine and standing SBPs were reduced by 15 mmHg and 13 mmHg, respectively." | 6.67 | An evaluation of the efficacy and safety of doxazosin in the treatment of hypertension associated with renal insufficiency. ( Anderton, JL; Notghi, A, 1990) |
| " The overall effect is partly due to an increase in the apparent bioavailability of prazosin but may also reflect a synergistic effect on reducing peripheral vascular resistance." | 6.66 | Verapamil and prazosin in essential hypertension: evidence of a synergistic combination? ( Elliott, HL; Meredith, PA; Reid, JL, 1987) |
| " Starting at one mg, dosage was doubled every 2 weeks during a 10-week treatment period to a maximum dose of 16 mg once daily." | 6.66 | Alpha-1 adrenoceptor blockade with doxazosin in hypertension: effects on blood pressure and lipoproteins. ( Ames, RP; Kiyasu, JY, 1989) |
| " Another multicenter trial reported that doxazosin therapy was effective at low doses; 76% of those responders achieved controlled blood pressure at a mean dosage of 3." | 6.66 | Efficacy and safety of doxazosin in hypertension therapy. ( Hayduk, K, 1987) |
| "Doxazosin is a once-daily, long-acting, selective alpha 1-adrenergic inhibitor that is effective for the treatment of essential hypertension." | 6.66 | Plasma lipid lowering effects of doxazosin, a new selective alpha1 adrenergic inhibitor for systemic hypertension. ( Pool, JL, 1987) |
| "Doxazosin is an effective hypotensive agent with beneficial effects on serum lipid levels." | 6.66 | A double-blind parallel trial to assess the efficacy of doxazosin, atenolol and placebo in patients with mild to moderate systemic hypertension. ( Black, H; Nash, DT; Reeves, RL; Schonfeld, G; Weidler, DJ, 1987) |
| "Doxazosin is an effective, well-tolerated, once-daily antihypertensive agent; it is comparable with terazosin but at a lower daily dosage." | 6.66 | Antihypertensive effects of doxazosin in systemic hypertension and comparison with terazosin. ( Hayduk, K; Schneider, HT, 1987) |
| "Felodipine is an effective antihypertensive agent when used with metoprolol." | 6.66 | Hormonal and blood pressure responses to tilting in beta-blocked essential hypertension treated with felodipine or prazosin. ( Jackson, B; Johnston, CI; McGrath, BP, 1987) |
| "Doxazosin monotherapy was effective in eight of 12 patients (66." | 6.66 | Doxazosin: a newly developed, selective alpha 1-inhibitor in the management of patients with pheochromocytoma. ( Miura, Y; Yoshinaga, K, 1988) |
| "Doxazosin is a new quinazoline derivative that, like prazosin, has selectivity for alpha 1-receptors." | 6.66 | Clinical pharmacology of doxazosin in patients with essential hypertension. ( Caplan, N; Cubeddu, LX; Ferry, D; Fuenmayor, N, 1987) |
| "The antihypertensive effects and steady-state pharmacokinetics of doxazosin, as well as the bioequivalence of four dosage forms, were studied in 25 hypertensive patients." | 6.66 | Doxazosin in patients with hypertension. ( Conrad, KA; Fagan, TC; Falkner, FC; Lazar, JD; Lee, S; Mackie, MJ; Mayshar, PV; Souhrada, JF, 1988) |
| " Further measurements were made during a series of intensive study days, and the most important additional finding was a pharmacokinetic interaction that resulted in increased peak concentrations and bioavailability of prazosin." | 6.66 | The combination of prazosin and verapamil in the treatment of essential hypertension. ( Campbell, L; Elliott, HL; Meredith, PA; Reid, JL, 1988) |
| "We compared antihypertensive effects of monotherapy with pinacidil (N = 197) or prazosin (N = 204) in a randomized, parallel, double-blind dose-titration study in which hydrochlorothiazide or propranolol could be added for adverse events or lack of efficacy." | 6.66 | Vasodilator monotherapy in the treatment of hypertension: comparative efficacy and safety of pinacidil, a potassium channel opener, and prazosin. ( Goldberg, MR; Rockhold, FW; Sushak, CS; Thompson, WL, 1988) |
| "The possibility to apply impedance cardiography technique and individual statistical analysis based on Dixon's criterion to pharmacodynamic studies of single hydralazine ( apressine ), prazosine ( pratsiol ), endralazine ( mirethilan ), propranolol (obsidan) doses is discussed." | 6.65 | [Methodologic approach to individual evaluation of the pharmacodynamic effects of single doses of hydralazine, endralazine, prazosine and propranolol in hypertension patients]. ( Izotov, AI; Postol'nikov, SF; Vygodin, VA, 1984) |
| "Prazosin has been used as an antihypertensive drug in the treatment of 93 patients in Dunedin since 1971-1972, mainly those whose previous control was unsatisfactory." | 6.64 | Use of prazosin at the dunedin hypertension clinic controlled and open studies and pharmacokinetic observations. ( Bolli, P; Simpson, FO; Wood, AJ, 1977) |
| "Prazosin appears to be a potent and appropriate third agent." | 6.64 | Evaluation of beta blockade bendrofluazide, and prazosin in severe hypertension. ( Barritt, DW; Heaton, ST; Marshall, AJ; Pocock, J, 1977) |
| "Prazosin was better tolerated, with side effects tending to diminish with time." | 6.64 | Prazosin and clonidine for moderately severe hypertension. ( Hammond, JJ; Kirkendall, WM; Overturf, ML; Thomas, JC; Zama, A, 1978) |
| " Dosage can be progressively increased up to 30 mg/day." | 6.64 | [Prazosine: a new vasodilator used for treatment of hypertension (author's transl)]. ( Bret, M; Fillastre, JP; Godin, M, 1978) |
| "Doxazosin therapy was associated with a trend toward correcting the disturbances of lipoprotein metabolism characteristic of NIDDM." | 6.38 | Doxazosin therapy in the treatment of diabetic hypertension. ( Feher, MD, 1991) |
| "The drug treatment of mild hypertension has been shown to afford protection against fatal and nonfatal strokes, congestive heart failure, progression to more severe levels of hypertension, and all-cause mortality, but not against the complications of coronary artery disease." | 6.38 | Pharmacologic basis for the use of doxazosin in the treatment of essential hypertension. ( Davey, MJ, 1989) |
| "Control of high blood pressure has failed to reduce the risk of atherosclerotic coronary heart disease (CHD)." | 6.38 | Review of the effects of doxazosin, a new selective alpha 1-adrenergic inhibitor, on lipoproteins in patients with essential hypertension. ( Nelson, EB; Pool, JL; Taylor, AA, 1989) |
| "Terazosin is a new long-acting, selective alpha 1-adrenergic antagonist." | 6.37 | Terazosin: a new long-acting alpha 1-adrenergic antagonist for hypertension. ( Eisen, G; Frishman, WH; Lapsker, J, 1988) |
| "The physicochemical properties, pharmacology, pharmacokinetics, cardiovascular and metabolic effects, adverse effects, dosage, and administration of doxazosin are described, and comparative clinical studies of doxazosin therapy in patients with mild to moderate hypertension are reviewed." | 6.17 | Doxazosin: a new alpha 1-adrenergic antagonist. ( Babamoto, KS; Hirokawa, WT, 1992) |
| "Prazosin is an orally active post-synaptic selective alpha 1-adrenoreceptor antagonist that has been widely used in treating hypertension and congestive heart failure (CHF)." | 6.15 | Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure. ( Brogden, RN; Kellerman, D; Romankiewicz, JA; Stanaszek, WF, 1983) |
| "The animal and human pharmacology of several new drugs (prazosin, trimazosin, pirbuterol, and carbazeran) useful in the treatment of congestive heart failure (CHF) is delineated in relation to the pharmacology of other agents employed for CHF management." | 6.15 | Comparative pharmacology and clinical efficacy of newer agents in treatment of heart failure. ( Baird, JR; Blackburn, KJ; Cambridge, D; Constantine, JW; Ghaly, MS; Hayden, ML; McIlhenny, HM; Moore, PF; Olukotun, AY; Pullman, LG; Salsburg, DS; Saxton, CA; Shevde, S; Taylor, CR, 1981) |
| "Terazosin, a new selective long-acting alpha1-adrenergic blocking agent, has been shown to be an effective once-daily antihypertensive agent in four of five randomized double-blind placebo-controlled studies of patients with mild to moderate hypertension." | 6.15 | Terazosin: a new alpha 1-blocker for the treatment of hypertension: a review of randomized, controlled clinical trials of once-daily administration as monotherapy. ( Glassman, HN; Horton, JK; Jordan, DC; Luther, RR; Sperzel, WD; Steinberg, FJ, 1986) |
| "The present study aims to assess and compare the effects of carvedilol and terazosin plus enalapril on lower urinary tract symptoms (LUTS), the urine flow, and blood pressure (BP) in patients with moderate hypertension (HTN) and benign prostatic hyperplasia (BPH)." | 5.41 | A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia. ( DalirAkbari, N; Farshi, A; Khalili, M; Mahmoudinezhad, M; Zomorrodi, A, 2021) |
| "Pheochromocytoma is a rare disease that may occur during pregnancy." | 5.30 | Pheochromocytoma in pregnancy manifesting hypertensive crisis induced by metoclopramide. ( Kinoshita, K; Seki, H; Takai, Y, 1997) |
| " Chronic administration of propranolol (5 or 50 mg." | 5.29 | Effects of propranolol and atenolol on immobilization stress-induced hypertension and down-regulation of central beta-adrenoceptors in rats. ( Kigoshi, S; Muramatsu, I; Oda, Y; Takita, M, 1995) |
| "Prazosin which is a selective alfa-1 blocking drug has a very good antihypertensive effect." | 5.28 | [Hemorheologic changes in patients with essential hypertension treated with prazosin]. ( Brkić, D; Gerc, V; Kamhi, J; Koblar, V, 1992) |
| "There is evidence that cardiac hypertrophy in spontaneously hypertensive rats (SHR) occurs before the development of hypertension." | 5.28 | Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension. ( Asano, H; Hashimoto, H; Ishikawa, K; Ito, T; Kondo, J; Okumura, K; Yoshino, M, 1992) |
| " Prazosin in combination with nadolol was found to level off the hyperprolactinemic effect of the latter without potentiating the reduction in the levels of follicle-stimulating, luteinizing, and testicular hormones which was observed during therapy with each drug alone." | 5.28 | [Effect of long-term treatment with prazosin and its combination with nadolol on the levels of blood hormones of the hypophyseal- gonadal system in patients with hypertension]. ( Akhmedova, ZG; Gumbatov, NB; Karaev, ME; Kasumova, FZ; Mamedova, RN; Mustafaev, II, 1992) |
| "Selected adverse events were evaluated from the combined randomized placebo-controlled clinical trials (once-a-day or twice-a-day; monotherapy or combination therapy) of terazosin in hypertensive patients." | 5.28 | Effect of age and dose on the incidence of adverse events in the treatment of hypertension in patients receiving terazosin. ( Hosmane, BS; Jordan, DC; Laddu, A; Maurath, CJ, 1992) |
| "Pretreatment with prazosin (0." | 5.28 | Quipazine-induced hypertension in anaesthetized cats is mediated by central and peripheral 5-HT2 receptors: role of the ventrolateral pressor area. ( Bouysset, F; Laubie, M; Schmitt, H; Vayssettes-Courchay, C; Verbeuren, TJ, 1991) |
| "Doxazosin, which has beneficial effects on haemodynamic factors and lipid metabolism, may be a suitable agent for treating these patients." | 5.28 | [The effect of doxazosin on blood pressure, lipids, fibrinogen and plasminogen activator inhibitor. A comparative study among smokers and non-smokers with essential hypertension]. ( Brusletto, B; Daae, LN; Holme, I; Kierulf, P; Syvertsen, JO; Westheim, A, 1991) |
| "Doxazosin is a postsynaptic alpha-1 adrenoceptor blocker suitable for once a day treatment regime." | 5.28 | [Doxazosin for the treatment of arterial hypertension]. ( Buzzaccarini, F; Casolino, P; Giusto, M; Mozzato, MG; Pessina, AC; Rubino, N; Semplicini, A; Serena, L; Valle, R, 1990) |
| "Although treatment of hypertension per se is important, blood pressure alone may not explain the course of the hypertrophic process." | 5.28 | Regression of left ventricular hypertrophy in hypertension. Effects of prazosin therapy. ( Corbett, J; Gonzalez, D; Kaplan, NM; Kulkarni, P; Ram, CV; Sunderajan, P; Taylor, A; Zachariah, NY, 1989) |
| " This indicates that small doses of prazosin (1-2 mg) cause significant in vivo shifts in the dose-response relationship of alpha adrenergic agonists." | 5.28 | Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy. ( Blaschke, TF; Eichler, HG; Ford, GA; Hoffman, BB; Swislocki, A, 1989) |
| " This doxazosin dosage reduced the diastolic blood pressure on average from 103 to 91 mmHg (P = 0." | 5.28 | Doxazosin, a new alpha-1-antagonist drug, controls hypertension without causing airways obstruction in asthma and COPD. ( Biernacki, W; Flenley, DC, 1989) |
| "Prazosin pretreatment and TAB prevented these effects." | 5.27 | Haemodynamic response to ketanserin in rabbits with Page hypertension: comparison with prazosin. ( Angus, JA; Wright, CE, 1983) |
| "Substance P (SP) plays an important role in central nervous and peripheral blood pressure regulation." | 5.27 | Substance P in human essential hypertension. ( Baumann, R; Enderlein, J; Faulhaber, HD; Naumann, E; Oehme, P; Rathsack, R; Rostock, G, 1987) |
| "Prazosin has been reported to reduce the hypotensive and/or bradycardic effect of clonidine in various animal models." | 5.27 | Prazosin partly blocks clonidine-induced hypotension in patients with essential hypertension. ( Farsang, C; Kapocsi, J; Vizi, ES, 1987) |
| "Prazosin was the result of an attempt to find a directly acting vasodilator drug with little or no effect on cardiac output, renin and salt and water metabolism." | 5.26 | The pharmacology of prazosin, an alpha 1-adrenoceptor antagonist and the basis for its use in the treatment of essential hypertension. ( Davey, MJ, 1982) |
| "Prazosin kinetics were studied after single doses (intravenous and oral, 0." | 5.26 | Prazosin kinetics in hypertension. ( Grahnén, A; Haglund, K; Lindström, B; Seideman, P; von Bahr, C, 1981) |
| " The dosage was increased, as necessary, by 1 tablet every 2 weeks to a maximum of 4 tablets daily to provide an adequate blood pressure response." | 5.26 | Treatment of Essential hypertension with single daily doses of a prazosin-polythiazide combination: a multicentre study with Minizide. ( Gordon, AJ; Woeltjen, AE, 1981) |
| "Prazosin kinetics were studied in 8 hypertensive patients (4 male and 4 female) with normal renal function." | 5.26 | Prazosin kinetics in essential hypertension. ( Chau, NP; Flouvat, BL; Le Roux, E; Safar, ME, 1980) |
| "Prazosin is an effective hypotensive agent, used alone or in combination, in most patients with hypertension of all degrees of severity." | 5.26 | Prazosin in hypertension. Part I. Clinical experience in 100 patients. ( Brocklehurst, JE; Turner, AS; Watson, OF, 1977) |
| "Prazosin appears to be a suitable substitute for hydralazine as an effective vasodialator if thiazides plus propranolol or thiazides plus reserpine or alpha-methyldopa are not effective." | 5.26 | Propranolol and newer antihypertensive drugs in the management of hypertension. ( Moser, M, 1979) |
| "(i) Prazosin is an effective and useful antihypertensive agent, best used with a diuretic and a beta-blocker." | 5.26 | Initial experience with prazosin in New Zealand. A multicentre report. New Zealand Hypertension Study Group. ( , 1977) |
| "To investigate the therapeutic efficacy and safety of Amlodipine alone or in combination with terazosin for the presence of lower urinary tract symptoms (LUTS) and hypertension." | 5.14 | Efficacy of combined amlodipine/terazosin therapy in male hypertensive patients with lower urinary tract symptoms: a randomized, double-blind clinical trial. ( Chen, G; Liu, H; Liu, P; Liu, Z; Mao, G; Na, Y; Qin, X; Wang, B; Wang, X; Xu, X, 2009) |
| "This prospective randomized double-blinded clinical trial was designed to explore the effects of amlodipine and the combination of amlodipine with terazosin in improving postvoid residual (PVR) in patients with lower urinary tract symptoms (LUTS) and concomitant hypertension." | 5.14 | [Amlodipine combined with terazosin reduces postvoid residual and the risk of acute urinary retention]. ( Fang, J; Li, YL; Liu, HP; Qin, XH; Xu, XP; Yang, C; Zhang, X, 2009) |
| "The result suggested that the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers and long-acting calcium antagonists were effective in treating essential hypertension, while the low-dose doxazosin, terazosin and torasemide can be used for combination therapy but not for monotherapy." | 5.12 | [Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring]. ( Cheng, XR; Hua, CX; Hua, L; Huang, Y; Kang, J; Li, N; Li, YS; Liu, H; Ming, GH; Pang, HM; Wang, L; Wu, Y; Xu, L; Xu, ZM, 2007) |
| "We determined the efficacy and safety of a relatively high dose of terazosin (5mg) in Korean patients with lower urinary tract symptoms (LUTS), with or without concomitant hypertension." | 5.12 | High-dose terazosin therapy (5mg) in Korean patients with lower urinary tract symptoms with or without concomitant hypertension: a prospective, open-label study. ( Ku, JH; Kwak, C; Lee, JK, 2007) |
| "To clarify the influence of hypertension on lower urinary tract symptoms (LUTS) we examined the relationship between blood pressure, LUTS, and the effect of terazosin on LUTS in patients with benign prostatic hyperplasia (BPH)." | 5.10 | Influence of hypertension on lower urinary tract symptoms in benign prostatic hyperplasia. ( Gakiya, M; Goya, M; Hatano, T; Ikehara, A; Kadekawa, K; Nakayama, T; Nashiro, F; Ogawa, Y; Sugaya, K, 2003) |
| "To investigate the relationship among serum nitric oxide, D-dimer, blood pressure, dangerous states and target organ damage in essential hypertension and to evaluate the effects of enalapril and terazosin." | 5.10 | [Serum nitric oxide and D-dimer before and after administering antihypertensive drugs in essential hypertension]. ( Luo, JK; Sun, M; Zhang, WR, 2003) |
| "The aim of this study was to evaluate the effectiveness and the safety of prazosin osmotic tablet treatment in non-insulin-dependent diabetic patients with mild to moderate arterial hypertension." | 5.09 | [Efficacy of and tolerance to prolonged release prazosin in patients with hypertension and non-insulin dependent diabetes]. ( Bernaud, C; Giacomino, A; Girerd, X; Hanon, O; Troy, S; Weber, S, 2000) |
| "In an open multicenter prospective study, the effects of short-term (4 weeks, n = 101) and long-term (6 months, n = 38) terazosin treatment on blood pressure, serum lipids and safety in the patients with mild to moderate essential hypertension were observed." | 5.09 | Effect of terazosin on blood pressure and serum lipids. ( Cheng, L; Gong, P; Lu, Z; Tang, J; Zeng, F; Zhang, J, 1999) |
| "To review and assess the cardiovascular safety of the alpha1-blocker terazosin when used to treat symptomatic benign prostatic hyperplasia (BPH) in patients taking concurrent antihypertensive medications." | 5.09 | Effects of terazosin therapy on blood pressure in men with benign prostatic hyperplasia concurrently treated with other antihypertensive medications. ( Lowe, FC; Olson, PJ; Padley, RJ, 1999) |
| "The effects of the alpha-1-adrenergic blocker terazosin on blood pressure and fasting and postprandial glucose and lipid metabolism were assessed in type 2 diabetic patients with hypertension." | 5.09 | Effects of a 3-month treatment with terazosin on fasting and postprandial glucose and lipid metabolism in type 2 diabetic patients with hypertension. ( Ferrara, LA; Imperatore, G; Iovine, C; Pasanisi, F; Vaccaro, O, 1999) |
| "To determine whether nifedipine or prazosin is the more appropriate second-line antihypertensive agent in pregnancy." | 5.09 | Nifedipine or prazosin as a second agent to control early severe hypertension in pregnancy: a randomised controlled trial. ( Hall, DR; Odendaal, HJ; Smith, M; Steyn, DW, 2000) |
| " In retrospective analyses of the Veterans Affairs Single-Drug Therapy for Hypertension Study, we compared changes in pulse pressure with 6 classes of antihypertensive agents: 1292 men with diastolic blood pressure of 95 to 109 mm Hg on placebo were randomized to receive hydrochlorothiazide, atenolol, captopril, clonidine, diltiazem, prazosin, or placebo." | 5.09 | Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial. ( Cushman, WC; Materson, BJ; Reda, DJ; Williams, DW, 2001) |
| " Twenty five unmedicated patients with primary hypertension were randomised to initial therapy with either the calcium antagonist, felodipine, or a diuretic and doses titrated to achieve similar levels of blood pressure (BP)." | 5.08 | Assessment of effects of two anti-hypertensive regimens on overall cardiovascular risk. ( Jennings, GL; Korner, P; Laufer, E; Reid, C; Sudhir, K, 1995) |
| "This was a double-blind randomized study comparing the efficacy of two alpha 1-antagonists, bunazosin retard and prazosin retard, in 185 patients with mild to moderate essential hypertension." | 5.08 | Orthostatic hypotension: how to avoid it during antihypertensive therapy. ( Rieckert, H, 1996) |
| "Patients with mild to moderate hypertension (diastolic blood pressure, 95 to 109 mm Hg) were randomly allocated to treatment with atenolol, captopril, clonidine, diltiazem, hydrochlorothiazide, or prazosin in a double-masked trial." | 5.08 | Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension: comparison of six antihypertensive agents. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. ( Anderson, RJ; Gottdiener, JS; Massie, BM; Materson, BJ; Reda, DJ; Williams, DW, 1997) |
| " This salt-induced increase in sympathetic responsiveness in the terminal aortic area was inhibited with the addition of benidipine, which abolished development of salt-induced hypertension and its accompanying haemodynamic responses." | 5.08 | Salt enhances responsiveness of terminal aortic vascular bed to sympathetic activity. ( Shimamoto, H; Shimamoto, Y, 1997) |
| " The FVC response following ischemia (14 min arterial occlusion with 3 min of hand exercise) was determined after systemic alpha 1-blockade (5 mg prazosin in preceding 24 h) in hypertensives (n = 11, MAP = 110 +/- 1, age = 24." | 5.08 | Effects of alpha 1-blockade on maximal vascular conductance in young borderline hypertensives. ( Franke, WD; Tegeler, NB, 1997) |
| "To determine the effects of terazosin on blood pressure and on antihypertensive therapy when used in managing benign prostatic hyperplasia (BPH)." | 5.08 | Terazosin in benign prostatic hyperplasia: effects on blood pressure in normotensive and hypertensive men. ( Kirby, RS, 1998) |
| "A double-blind, double-dummy, parallel-group trial that used a predominantly Hispanic patient population with mild-to-moderate hypertension was designed to compare the efficacy, safety, and acceptability of monotherapy with either transdermal clonidine applied once a week or terazosin tablets taken once a day." | 5.08 | Alpha 2-agonist versus alpha 1-antagonist in mild-to-moderate hypertension: comparison of transdermal clonidine and terazosin monotherapies. ( Alvarez, C; Harris, SI, 1997) |
| "This study reviews and assesses the safety of terazosin for the treatment of symptomatic benign prostatic hyperplasia (BPH)." | 5.07 | Safety assessment of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia: a combined analysis. ( Lowe, FC, 1994) |
| "Terazosin is safe and effective in treating concomitant hypertension and BPH." | 5.07 | Terazosin in the treatment of hypertension and symptomatic benign prostatic hyperplasia: a primary care trial. ( Guthrie, R, 1994) |
| "The antihypertensive efficacy of single-drug therapy with nifedipine (N), prazosin (P), or acebutolol (A) and the influence of these agents on coronary risk factors including hypoglycemia, hyperuricemia, and hyperlipidemia, were studied in adolescents with hypertension." | 5.07 | [Evaluation of the efficacy and tolerance of three antihypertensive agents used as single-drug therapy, nifedipine, prazosin and acebutolol in severe, idiopathic hypertension in adolescents]. ( Cichocka, E; Januszewicz, P; Wyszynska, T, 1993) |
| "The effects of six weeks of treatment with the selective peripheral alpha 1-adrenoceptor blocker terazosin, or the selective beta 1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were compared in a single-blind, randomized, crossover study of 17 patients with mild-to-moderate essential hypertension." | 5.07 | A comparison of the effects of the selective peripheral alpha 1-blocker terazosin with the selective beta 1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension. ( Cleland, J; Coles, SJ; Humphreys, J; Ligueros, M; Unwin, R; Wilkins, MR, 1992) |
| " In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase." | 5.07 | Increase in serum total angiotensin-converting enzyme activity with enalapril therapy in humans: a controlled trial. ( Johnston, H; Marwood, JF; Monaghan, JC; Okoro, EO; Stokes, GS, 1992) |
| "Terazosin is a selective alpha 1-adrenoceptor antagonist; its actions on the serum lipoprotein profile were compared with those of the cardioselective beta-adrenoceptor antagonist atenolol in 40 patients with mild to moderate hypertension." | 5.07 | Comparison of antihypertensive and lipid actions of terazosin and atenolol in essential hypertension. ( Guy, S; Humphreys, JE; Silke, B, 1992) |
| "Twenty-two patients with diabetes and hypertension were treated with Doxazosin." | 5.07 | Doxazosin in the management of hypertensive diabetes--a cautionary note (?). ( Daly, L; Devlin, JG; McLaughlin, B, 1992) |
| "The antihypertensive efficacy and safety of doxazosin (once daily) and prazosin (twice daily) were compared in patients with mild or moderate essential hypertension (diastolic blood pressure [DBP] 95 to 114 mm Hg) not adequately controlled by diuretics and beta-blockers." | 5.07 | A double-blind comparative study of doxazosin and prazosin when administered with beta-blockers or diuretics. ( de Planque, BA, 1991) |
| "When doxazosin was given to patients with hypertension not adequately controlled by beta-blockade, blood pressure was normalized in 94% of the 34 patients (blood pressure less than or equal to 140/85 mm Hg)." | 5.07 | The addition of doxazosin to the treatment regimen of patients with hypertension not adequately controlled by beta-blockers. ( Barlage, U; Englert, RG, 1991) |
| "The safety, efficacy and the effect on the plasma total cholesterol of once-daily terazosin hydrochloride administered as monotherapy was evaluated in 69 patients with mild-moderate untreated essential hypertension in this open, hospital, multi-centre, 3 month study." | 5.07 | A multicentre, hospital study of the efficacy and safety of terazosin and its effects on the plasma cholesterol levels of patients with untreated essential hypertension. ( Coles, S; Lytle, T; Waite, MA, 1991) |
| "Terazosin is a selective alpha 1-adrenergic-blocking agent indicated for the treatment of hypertension." | 5.07 | Antihypertensive dose-response relationships: studies with the selective alpha 1-blocking agent terazosin. ( Cheung, DG; Laddu, AR; Luther, RR; Weber, MA, 1991) |
| "This open, multicenter phase III study was designed to assess the efficacy and long-term safety of terazosin (1 to 40 mg/day), alone or in combination with other antihypertensive drugs, in 364 patients with mild to moderate essential hypertension." | 5.07 | Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents. ( Cohen, JD, 1991) |
| "The safety, efficacy and the effect on the plasma total cholesterol of once-daily terazosin hydrochloride administered either as monotherapy or in combination with other antihypertensive therapy were evaluated in patients with mild-moderate uncontrolled essential hypertension in this U." | 5.07 | A multicentre, hospital study of the efficacy and safety of terazosin and its effects on the plasma cholesterol levels of patients with essential hypertension. ( Coles, SJ; Lytle, TB; Waite, MA, 1991) |
| "This study investigated the safety and efficacy of doxazosin treatment in a large population of patients (n = 336) with essential hypertension and assessed the effect of doxazosin on the serum lipid profile and the calculated risk of developing coronary heart disease." | 5.07 | Clinical experience with doxazosin in general medical practice in New Zealand. ( Maslowski, AH, 1991) |
| "This Latin American study assessed in the general practice setting the efficacy and tolerance of once-daily doxazosin in the treatment of mild or moderate essential hypertension (sitting diastolic blood pressure, 95 to 115 mm Hg)." | 5.07 | Doxazosin in the treatment of essential hypertension in general medical practice in Latin America. ( Fonseca, R; Marshall, D; Silva, H, 1991) |
| "This study was designed to assess the efficacy and tolerance of doxazosin in patients with mild, moderate, or severe essential hypertension in a general practice setting." | 5.07 | A multicenter study of doxazosin in the treatment of essential hypertension in France. ( Bonnet, G, 1991) |
| "This study was designed to investigate the efficacy and toleration of once-daily doxazosin in the treatment of essential hypertension (sitting diastolic blood pressure 95 to 115 mm Hg) in a general medical practice." | 5.07 | Clinical experience with doxazosin in general medical practice in The Netherlands. ( Harmse, DP, 1991) |
| "This study assessed the long-term (54 weeks) antihypertensive efficacy and safety of doxazosin in the treatment of mild or moderate essential hypertension, defined as sitting and standing diastolic blood pressure of 95 to 114 mm Hg." | 5.07 | A long-term study of doxazosin in the treatment of mild or moderate essential hypertension in general medical practice. ( Manos, J, 1991) |
| "Sixteen patients with mild or moderate essential hypertension received 1 to 8 mg/day of doxazosin (mean daily dose, 2." | 5.07 | Doxazosin in the treatment of mild or moderate essential hypertension: an echocardiographic study. ( Corral, JL; López, NC; Pecorelli, A; Rincón, LA; Terán, VD, 1991) |
| "A single daily dose of doxazosin taken during a 12-week period produced a significant reduction in blood pressure and left ventricular mass index in patients with mild or moderate hypertension." | 5.07 | Echocardiographic assessment of doxazosin on left ventricular mass in patients with essential hypertension. ( Fonseca, R; López, B; Lugo de Franco, V; Medina, O; Monsalve, P; Ostojich, K; Pérez Acuña, F; Torres, N; Vera, O, 1991) |
| " Forty-two patients, ages 42 to 65 years, including 21 men with sustained hypertension and elevated serum cholesterol levels, were included in a trial of monotherapy with doxazosin administered once daily (range, 1 to 16 mg)." | 5.07 | Efficacy and safety of doxazosin in the treatment of patients with mild or moderate essential hypertension and elevated levels of cholesterol. ( Taylor, SH, 1991) |
| "This study assessed the efficacy and safety of once-daily doxazosin in the treatment of patients (n = 19) with mild or moderate essential hypertension (sitting diastolic blood pressure [DBP] 95 to 114 mm Hg) and concomitant intermittent claudication (Doppler ankle/arm ratio of less than 0." | 5.07 | A multicenter study of doxazosin in the treatment of patients with mild or moderate essential hypertension and concomitant intermittent claudication. ( Catalano, M; Libretti, A, 1991) |
| "Prazosin hydrochloride SR in a single daily dose seems to be an advance in the treatment of patients with mild and moderate hypertension." | 5.06 | [Anti-hypertensive efficacy and tolerability of sustained-release prazosin hydrochloride. A Brazilian multicenter study]. ( Spritzer, N, 1990) |
| "Doxazosin (mean dose 11 mg) given once daily in combination with 100 mg atenolol (n = 44) was compared with placebo and atenolol (n = 43) in a double-blind, multicenter study in patients with mild to moderate essential hypertension." | 5.06 | Doxazosin in combination with atenolol in essential hypertension: a double-blind placebo-controlled multicentre trial. ( Christensen, CC; Dathan, R; Dean, S; Searle, M; Westheim, A, 1990) |
| "The efficacy and tolerability of doxazosin and atenolol in the management of mild and moderate hypertension were compared in a multicentre, parallel study, the first year of which was randomized and double-blind." | 5.06 | A long-term study of atenolol and doxazosin in mild and moderate hypertension. ( Daae, L; Talseth, T; Westlie, L, 1990) |
| "The antihypertensive effect and safety of doxazosin once daily as well as the effect on serum lipids was compared with that of atenolol once daily in 40 patients with mild to moderate hypertension." | 5.06 | Antihypertensive effect of doxazosin and atenolol in short- and long-term double-blind comparison. ( Amery, A; Fagard, R; Lijnen, P; Staessen, J, 1990) |
| "A group of 55 black men with mild or moderate hypertension who were being treated with methyldopa, prazosin, and a thiazide diuretic in combination with sotalol, were studied before and after changing their treatment to captopril and a thiazide diuretic." | 5.06 | Captopril in hypertensive black men in southern Africa. ( Cowie, RL; Dansey, RD, 1990) |
| "The paper deals with the study into the benefits of prazosin and trasicor used in arterial hypertension." | 5.06 | [Changes in lipid fractions of blood during the treatment of hypertension with prazosin and trasicor]. ( Damiĭonaĭtene, RA; Kuchinskene, ZZ; Rugenius, IuIu; Steponenene, RV; Vidugiris, AI, 1990) |
| "Guanfacine, an alpha 2 adrenoceptor agonist, was compared with prazosin hydrochloride for the treatment of patients with mild to moderate essential hypertension in an 8-week, double-blind, randomized, parallel evaluation to determine efficacy and safety." | 5.06 | Antihypertensive efficacy of guanfacine and prazosin in patients with mild to moderate essential hypertension. ( Alderman, MH; Lewin, A; Mathur, P, 1990) |
| "The antihypertensive effect and the influence on lipid metabolism of the alpha-receptor blocking drugs indoramin and prazosin given in combination with hydrochlorothiazide were investigated in patients with mild to moderate essential hypertension." | 5.06 | Comparison of the effect of indoramin and prazosin on blood pressure and lipid profiles in essential hypertension. ( Overlack, A; Stumpe, KO, 1986) |
| "The safety and efficacy of indoramin and prazosin added to hydrochlorothiazide (HCTZ) were compared in a double-blind trial involving 209 patients with mild to moderately severe essential hypertension." | 5.06 | Antihypertensive effects of indoramin and prazosin in combination with hydrochlorothiazide. ( Solomon, R, 1986) |
| "Felodipine was compared with prazosin in patients with essential hypertension whose blood pressure was not controlled by a beta-blocking drug." | 5.06 | Felodipine compared to prazosin as additional therapy to a beta-blocking drug. ( Bune, A; Chalmers, J; Heath, W; Jackson, B; Johnston, C; Mashford, ML; McGrath, B; West, M; Westwood, B; Wing, L, 1987) |
| "Twenty-three patients with essential hypertension were treated consecutively with prazosin or dihydrochlorothiazide or the combination of the two, each treatment period lasting for three months." | 5.06 | Prazosin improves atherogenic index and inhibits the deleterious effect of dihydrochlorothiazide in patients with essential hypertension. ( Balás-Eltes, A; Farsang, C; Fehér, J; Péter, M, 1987) |
| "The antihypertensive effect and safety of doxazosin once-daily was compared with that of atenolol once-daily in 40 patients with mild to moderate hypertension." | 5.06 | Short-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension. ( Amery, A; Fagard, R; Lijnen, P; Staessen, J, 1988) |
| "The antihypertensive effect and safety of doxazosin once daily as well as the effect on serum lipids was compared with that of atenolol once daily in 40 patients with mild to moderate hypertension." | 5.06 | Long-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension. ( Amery, A; Fagard, R; Lijnen, P; Lissens, W; Staessen, J, 1989) |
| "In an acute, double-blind, crossover study on 12 patients with essential hypertension, the interaction between nifedipine and prazosin was investigated in the supine position." | 5.06 | Nifedipine-prazosin interaction in patients with essential hypertension. ( Farsang, C; Kiss, I, 1989) |
| "The haemodynamic effect of one-week prazosin therapy was investigated in 21 patients with essential hypertension (9 of WHO stage I, 12 of stage II)." | 5.06 | Haemodynamic effect of prazosin during hyperosmolar mannitol load in essential hypertension. ( Ondrejka, P; Pechán, J; Veres, I, 1989) |
| "The effects of once-daily therapy with doxazosin (1 to 8 mg/day) on exercise capacity, left ventricular performance and hemodynamics (radionuclide ventriculography) were compared with those of atenolol (50 to 100 mg/day) and placebo in a randomized, double-blind crossover trial in 16 patients (9 men) with mild hypertension." | 5.06 | Comparison of doxazosin and atenolol in mild hypertension, and effects on exercise capacity, hemodynamics and left ventricular function. ( Bautovich, GJ; Fletcher, PJ; Gillin, AG; Horvath, JS; Hutton, BF; Tiller, DJ, 1989) |
| " This study investigates aspects of the pharmacokinetics, pharmacodynamics and concentration-effect relationships in 10 patients with essential hypertension during acute and chronic treatment with doxazosin, an alpha 1-adrenoceptor antagonist." | 5.06 | Concentration-effect relationships and individual responses to doxazosin in essential hypertension. ( Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL, 1989) |
| "In a single-blind, crossover study, prazosin and enalapril monotherapies were evaluated in 15 patients, aged 55 years or older (average age, 64 years), with mild hypertension (sitting diastolic blood pressure between 90 and 104 mm Hg)." | 5.06 | Mild hypertension in the elderly. A comparison of prazosin and enalapril. ( Cheung, DG; Hoffman, CA; Ricci, ST; Weber, MA, 1989) |
| "This study evaluated the overall efficacy and safety of two specific vasodilators--the alpha-blocker prazosin and the angiotensin-converting enzyme inhibitor captopril--in the treatment of mild-to-moderate essential hypertension." | 5.06 | Selective alpha-blockade versus angiotensin-converting enzyme inhibition as initial antihypertensive therapy. Effects on circulating lipoproteins. ( Cervenka, JH; Dinh, T; O'Connor, DT; Takiyyuddin, MA; Witztum, JL, 1989) |
| "The long-term effects of prazosin and propranolol therapy were compared over the course of one year in 93 patients with mild-to-moderate hypertension." | 5.06 | Evaluation of the efficacy of prazosin versus propranolol as initial antihypertensive therapy. ( Alderman, MH, 1989) |
| "A randomized, drug-controlled trial was conducted to evaluate the comparative efficacy of hydrochlorothiazide versus prazosin in controlling mild diastolic hypertension in black and white patients." | 5.06 | Prazosin versus hydrochlorothiazide as initial antihypertensive therapy in black versus white patients. ( Batey, DM; Jeffrey, SS; Lasser, NL; Lasser, VI; Nicolich, MJ, 1989) |
| "M-mode echocardiography was used in 80 patients with essential hypertension to study changes in the index of left ventricular mass during treatment over 3 years with reserpine, prazosin, indapamide and atenolol, separately or in combination." | 5.06 | The effect of chronic antihypertensive therapy on the index of left ventricular mass in patients with essential hypertension. ( Duman, EL; Komsuoğlu, B; Komsuoğlu, SS; Ozgür, O, 1989) |
| "The results of a comparative study of the action of a new Soviet agent prazosin in arterial hypertension patients have shown that it does not differ in its pharmacokinetic characteristics from its Finnish analogue and is an effective hypotensive agent." | 5.06 | [Effectiveness of the Russian drug prazosin in patients with arterial hypertension (Working Group for the Cooperative Study of New Drugs in the Prevention of Arterial Hypertension (CSDPAH)]. ( , 1989) |
| "The efficacy and safety of prazosin GITS (gastro-intestinal therapeutic system), a new extended-release once-a-day formulation, were assessed both as monotherapy in mild essential hypertension and in combination with a diuretic in moderate essential hypertension in two multicenter, double-blind, placebo-controlled trials." | 5.06 | Efficacy and safety of Minipress XL, a new once-a-day formulation of prazosin. ( Bottiglieri, DF; Dix, RK; Levenstein, M; Moisey, D; Monsen, L; Silver, L; Singleton, W, 1989) |
| "Multicenter study of the effectiveness and safety of prazosin (Minipress) in patients with arterial hypertension was carried out in 15 medical centers." | 5.06 | [Minipress in the treatment of arterial hypertension in light of results from a multicenter study. I. 3-month treatment: monotherapy versus combination treatment]. ( Sznajderman, M, 1989) |
| "Of 218 patients with arterial hypertension, who responded to monotherapy with prazosin (Minipress) during the first 3 months, 178 persons completed the 12-month treatment according to the study protocol." | 5.06 | [Minipress in the treatment of arterial hypertension in light of results from a multicenter study. II. Results of long-term monotherapy]. ( Sznajderman, M, 1989) |
| "The purpose of this study was to compare the effects of the serotonin antagonist ketanserin and the post-synaptic alpha-blocker prazosin on blood pressure in patients with essential hypertension." | 5.06 | Moderate essential hypertension control: a double-blind crossover study between a serotonin antagonist and a post-synaptic alpha-blocker. ( Fisher, R; Gruebel, B; Koehle, W; Rosenthal, J, 1986) |
| "The safety and efficacy of once-daily terazosin as monotherapy were evaluated in five randomized, double-blind, placebo-controlled studies in which 351 patients with mild to moderate hypertension participated." | 5.06 | Terazosin: an effective once-daily monotherapy for the treatment of hypertension. ( Dauer, AD, 1986) |
| "The effect of withdrawal of terazosin therapy in patients with mild to moderate hypertension was assessed in two double-blind, placebo-controlled studies." | 5.06 | Effect of withdrawal of terazosin therapy in patients with hypertension. ( Ruoff, G, 1986) |
| "The efficacy and safety of terazosin were compared with those of other antihypertensive drugs in three parallel-group, randomized, double-blind studies in which 133 patients with mild to moderate hypertension participated." | 5.06 | Comparative trials of terazosin with other antihypertensive agents. ( Ruoff, G, 1986) |
| "In a randomized, double-blind, placebo-controlled, multicenter trial, the efficacy and safety of terazosin in combination with other antihypertensive agents were assessed using patients with inadequately controlled essential hypertension (supine diastolic blood pressure 95 mm Hg or greater)." | 5.06 | Experience with terazosin administered in combination with other antihypertensive agents. ( Chrysant, SG, 1986) |
| "In a multicenter, double-blind, placebo-controlled study, the efficacy and safety of terazosin and prazosin were compared in patients with mild to moderate essential hypertension." | 5.06 | Comparison of the safety and efficacy of once-daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension. ( Deger, G, 1986) |
| "A total of 713 patients with hypertension were evaluated in eight randomized, double-blind, placebo-controlled trials of terazosin administered in single daily doses ranging from 1 to 40 mg." | 5.06 | Efficacy of terazosin as an antihypertensive agent. ( Glassman, HN; Jordan, DC; Luther, RR; Sperzel, WD, 1986) |
| "The effect of the selective alpha 1-antagonist terazosin on serum lipoproteins and certain blood pressure-regulating factors was assessed in 15 patients with essential hypertension." | 5.06 | Alpha-1-adrenergic blockade and lipoprotein metabolism in essential hypertension. ( Beretta-Piccoli, C; Ferrier, C; Mordasini, R; Weidmann, P, 1986) |
| "The long-term safety, efficacy and effect on serum lipid profile of doxazosin, a new alpha 1-adrenoceptor inhibitor administered once daily, were compared with those of prazosin, administered twice daily, in 104 patients with essential hypertension treated for 1 year." | 5.06 | An open one-year comparison of doxazosin and prazosin for mild to moderate essential hypertension. ( Madsbu, HP; Torvik, D, 1987) |
| "9 mg, range 1 to 16) in the treatment of essential hypertension were compared in a double-blind study with those of hydrochlorothiazide (HCTZ) (mean dosage, 84." | 5.06 | Comparative effects of doxazosin and hydrochlorothiazide on serum lipids and blood pressure in essential hypertension. ( Claessens, J; Nelemans, F; Riesen, W; Streulens, Y; Trost, BN; Weidmann, P, 1987) |
| "Chronic responses of systemic hemodynamics and blood pressure counterregulatory ("pseudo-tolerance") mechanisms were investigated in matched groups of patients with essential hypertension after 1 month of vasodilator therapy with pinacidil (a direct arterial dilator), prazosin (an alpha 1-adrenergic blocking drug) or captopril (an angiotensin-converting enzyme inhibitor)." | 5.06 | Chronic effects of direct vasodilation (pinacidil), alpha-adrenergic blockade (prazosin) and angiotensin-converting enzyme inhibition (captopril) in systemic hypertension. ( Izzo, JL; Kallay, MC; Larrabee, PS; Licht, MR; Radke, KJ; Smith, RJ, 1987) |
| "The effects of prazosin and beta-blocker monotherapy on serum concentrations of triglycerides, cholesterol, and lipoprotein cholesterol were evaluated in 16 patients with mild to moderate essential hypertension in a single-blind, cross-over, placebo-controlled study." | 5.06 | Effect of prazosin and beta-blocker monotherapy on serum lipids: a cross-over, placebo-controlled study. ( Carlson, JD; Dietz, AJ; Freeman, DS; Magarian, EO, 1987) |
| "The efficacy and tolerability of felodipine and prazosin were compared in a double-blind randomised parallel group study of 100 patients with moderately severe essential hypertension, treated concomitantly with a beta-blocking drug." | 5.06 | Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study. ( Anderson, A; Gibson, J; Jackson, B; Morgan, TO, 1987) |
| "The long-term treatment of essential hypertension with terazosin, a new once-a-day alpha 1-adrenergic blocking agent, was evaluated in 364 hypertensive patients who received total daily doses of 1 to 40 mg for 3 weeks to 56 months." | 5.06 | Terazosin, a new selective alpha 1-adrenergic blocking agent. Results of long-term treatment in patients with essential hypertension. ( Estep, CB; Glassman, HN; Horton, JK; Jordan, DC; Luther, RR; Schmitz, PJ, 1988) |
| "The efficacy and toleration of doxazosin and atenolol were compared over a 52-week period in a double-blind, multicenter study of 228 patients with mild-to-moderate hypertension." | 5.06 | Comparison of the effects of doxazosin and atenolol on blood pressure and blood lipids: a one-year, double-blind study in 228 hypertensive patients. ( Daae, L; Talseth, T; Vatle, S; Westlie, L, 1988) |
| "Fourteen male patients (mean age +/- SD, 52 +/- 11 years) with a history of hypertension (systolic blood pressure, 148 +/- 10 mm Hg; diastolic blood pressure, 99 +/- 2 mm Hg) were enrolled in a cross-over trial of prazosin and atenolol, with a minimum of eight weeks of treatment with each drug." | 5.06 | Effect of alpha- and selective beta-blockade for hypertension control on plasma lipoproteins, apoproteins, lipoprotein subclasses, and postprandial lipemia. ( Krauss, RM; Superko, HR; Wood, PD, 1989) |
| "The efficacy and tolerability of the alpha-blocker prazosin was compared with that of atenolol, a beta-blocker, in the long-term treatment of uncomplicated, essential hypertension." | 5.06 | The long-term antihypertensive effects of prazosin and atenolol. ( Itskovitz, HD; Khoury, S; Krug, K; Mollura, JL, 1989) |
| "The effects of prazosin therapy were recently evaluated in ambulatory patients with essential hypertension and chronic obstructive pulmonary disease." | 5.06 | Prazosin in hypertensive patients with chronic bronchitis and asthma: a brief report. ( Chodosh, S; Pizzuto, D; Tuck, J, 1989) |
| "A 12-week double-blind study was performed to compare the safety and efficacy of doxazosin, prazosin and placebo in 172 patients with essential hypertension." | 5.06 | Multicentre 12-week double-blind comparison of doxazosin, prazosin and placebo in patients with mild to moderate essential hypertension. ( Madsbu, HP; Torvik, D, 1986) |
| "The effects on plasma lipids and apoproteins A-I and B of oral administration of doxazosin and atenolol over a 20-week period were studied in 42 patients with mild to moderate essential hypertension." | 5.06 | Double-blind comparison of the effects of long-term treatment with doxazosin or atenolol on serum lipoproteins. ( Himanen, P; Lehtonen, A; Marniemi, J; Niittymäki, K; Saraste, M, 1986) |
| "Doxazosin is a long-acting selective alpha 1-adrenoceptor antagonist which has been shown to be effective and well tolerated in the treatment of hypertension given in once-daily doses as monotherapy for up to 1 year or as an adjunct to thiazide or beta-adrenoceptor blockers." | 5.06 | The antihypertensive effects of doxazosin: a clinical overview. ( Cox, DA; Leader, JP; Milson, JA; Singleton, W, 1986) |
| "A randomized crossover trial was conducted in 15 patients with essential hypertension to compare the actions of prazosin, a specific alpha 1-adrenoceptor blocker, and ketanserin, an antagonist at alpha 1-adrenergic and serotonin receptors." | 5.06 | Ketanserin and prazosin: a comparison of antihypertensive and biochemical effects. ( Marwood, JF; Mennie, BA; Stokes, GS, 1986) |
| "The safety and antihypertensive efficacy of PN 200-110 (isradipine), a novel calcium antagonist, are discussed in a preliminary report of double-blind, multicenter, controlled, phase III clinical trials for essential hypertension." | 5.06 | Treatment of essential hypertension with PN 200-110 (isradipine). ( Hamilton, BP, 1987) |
| "The pharmacodynamics of doxazosin and atenolol were compared on single study days in 39 patients with mild to moderate hypertension receiving long-term double-blind treatment." | 5.06 | The pharmacokinetics and pharmacodynamics of doxazosin compared with atenolol during long-term double-blind treatment. ( Faulkner, JK; Himanen, P; Karjalainen, U; Saraste, M, 1987) |
| " Since left ventricular hypertrophy may be an important determinant of outcome in hypertension, the long-term effects of arterial vasodilation with hydralazine on left ventricular mass and function were compared with those of an alternative third-line drug, the alpha1 blocker prazosin, in patients still hypertensive despite combined diuretic and beta blocker therapy." | 5.06 | Vasodilators and regression of left ventricular hypertrophy. Hydralazine versus prazosin in hypertensive humans. ( Farkas, RM; Leenen, FH; Marquez-Julio, A; Reeves, RA; Smith, DL, 1987) |
| "The efficacy and safety of doxazosin (DOX) for the treatment of hypertension was investigated." | 5.06 | Effect of doxazosin monotherapy on blood pressure and plasma lipids in patients with essential hypertension. ( Bloomfield, R; Cubeddu, LX; Halperin, A; Klotman, PE; Nelson, EB; Pickering, BI; Pool, JL; Wombolt, DG, 1988) |
| "The antihypertensive efficacy of the new, once daily, alpha 1-adrenoceptor inhibitor, doxazosin, was compared with placebo in 40 patients with mild to moderate hypertension." | 5.06 | 24-hour control of blood pressure by once daily doxazosin: a multicentre double-blind comparison with placebo. ( Jackson, G; Lorimer, AR; Pringle, S; Smyth, P, 1988) |
| "A multicentre double-blind comparative study of urapidil and prazosin was performed in 412 outpatients with mild to moderate essential hypertension." | 5.06 | Double-blind comparison of urapidil and prazosin in the treatment of patients with essential hypertension. ( Kaneko, Y, 1988) |
| "We compared the effect on serum lipids of an alpha-blocker (prazosin) and a diuretic (hydrochlorothiazide) used as initial antihypertensive drug treatment for 102 men and women with less severe hypertension (average entry blood pressure, 148/97 mm Hg, with no major organ system damage)." | 5.06 | Initial antihypertensive drug therapy. Final report of a randomized, controlled trial comparing alpha-blocker and diuretic. ( Berkson, DM; Dyer, AR; Gosch, FC; Hershinow, P; Stamler, J; Stamler, R, 1988) |
| "A comparative study between prazosin and propranolol with twenty male patients with mild to moderate essential hypertension was used to study the effects of these antihypertensive agents on plasma lipoproteins, and more specifically high density lipoproteins-2 and Apo A-I." | 5.06 | Effect of prazosin and propranolol on lipoproteins of hypertensive patients. ( Camejo, G; Hurt, E; Silva, H; Velasco, M, 1987) |
| "The safety and efficacy of once-daily terazosin hydrochloride administered concomitantly with once-daily atenolol for the treatment of essential hypertension were evaluated in this double-blind, multiclinic, placebo-controlled study." | 5.06 | Concomitant administration of terazosin and atenolol for the treatment of essential hypertension. ( Holtzman, JL; Kaihlanen, PM; Lewin, AJ; Oberlin, JA; Rider, JA; Spindler, JS, 1988) |
| " In nine patients with essential hypertension, following single and multiple doses of ketanserin, assessments were made of blood pressure and heart rate, QT interval, and pressor responses to phenylephrine and angiotensin II." | 5.06 | Acute and chronic ketanserin in essential hypertension: antihypertensive mechanisms and pharmacokinetics. ( Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL, 1987) |
| "Patients with essential hypertension were randomized to treatment with either prazosin or pinacidil, a new direct-acting vasodilator." | 5.06 | Comparative effects of pinacidil and prazosin on blood pressure, weight, plasma volume, the renin-angiotensin-aldosterone system, and the renal kallikrein-kinin system in patients with essential hypertension. ( Solomon, RJ; Weinberg, MS, 1987) |
| "We have carried out randomized 12-week multicentre study to compare the effects of prazosin and propranolol on blood pressure and serum lipids in 70 patients with essential hypertension after a 4 week minimum period of treatment with thiazide diuretics." | 5.06 | The effects of prazosin and propranolol in combination with thiazide diuretics on blood pressure and serum lipids: a multicentre study. ( Abe, A; Fujimori, I; Fukui, T; Goto, Y; Iyori, S; Maeda, T; Ogasawara, Y; Takei, Y; Tamura, T; Tanabe, T, 1987) |
| "To compare the effects of prazosin and atenolol on plasma lipid concentrations, 60 patients with arterial hypertension (diastolic 90 to 120 mm Hg, systolic 160 to 200 mm Hg) were allocated at random to one of two treatment groups." | 5.06 | Effects of two antihypertensive agents on lipids, lipoproteins, and apoproteins A and B. Comparison of prazosin and atenolol. ( Jaillard, J; Rouffy, J, 1986) |
| "The effects of prazosin and atenolol monotherapy on plasma lipid concentrations were compared in 51 patients with mild to moderate essential hypertension." | 5.06 | Effects of prazosin, atenolol, and thiazide diuretic on plasma lipids in patients with essential hypertension. ( Lowenstein, J; Neusy, AJ, 1986) |
| "Clinical trials of the alpha-adreno-blocker prazosin (Pratsiol as produced by "Orion", Finland) were carried out in 42 patients with essential hypertension, stages 2-3 by WHO classification, and 3 patients with nephrogenic hypertension." | 5.06 | [Use of prazosin in patients with hypertension]. ( Gorbacheva, ON; Kharchenko, VI; Liusov, VA; Mart'ianova, II; Mikhaĭlusova, MP, 1986) |
| "The clinical effect of the peripheral vasodilator prazosin (Adwersuten, GDR) was studied in 51 patients with second-stage essential hypertension." | 5.06 | [Analysis of hypotensive and hemodynamic effects of prazosin in patients with hypertension]. ( Dobrotvorskaia, TE; Ostapiuk, FE; Samofanova, MS; Shengeliia, RG, 1986) |
| "After a clinical trial was completed in which two commonly used antihypertensive agents (prazosin and propranolol) were compared, 20 previously untreated men with moderate, asymptomatic, essential hypertension returned to the care of their general practitioners." | 5.06 | Effect of trial therapy on subsequent therapy. A review of patients with hypertension who have completed a pharmacological intervention study. ( Carney, SL; Floate, LF; Gillies, AH; Smith, AJ, 1986) |
| "A randomized, parallel group study evaluated the safety, efficacy, and effect of the alpha blocking agent prazosin and the angiotensin converting enzyme inhibitor captopril on serum lipid levels in patients with mild to moderate hypertension." | 5.06 | Prazosin versus captopril as initial therapy. Effect on hypertension and lipid levels. ( Kraut, J; Okun, R, 1987) |
| "In 93 patients with hypertension uncontrolled by bendrofluazide 5 mg plus atenolol 100 mg daily, the effects of adding nifedipine (up to 60 mg/day, n = 31), prazosin (up to 20 mg/day, n = 31), or hydralazine (up to 200 mg/day, n = 31) were compared in a 6 month open random parallel group study." | 5.06 | Comparison of nifedipine, prazosin and hydralazine added to treatment of hypertensive patients uncontrolled by thiazide diuretic plus beta-blocker. ( Parnell, L; Ramsay, LE; Waller, PC, 1987) |
| "Eleven patients with uncomplicated essential hypertension received increasing single daily doses of UK-33,274, a new alpha-1 adrenoceptor antagonist, and prazosin for 4 days, in a open cross-over study." | 5.05 | Within patient comparison of prazosin and UK-33,274. A new alpha-adrenoceptor-antagonist. ( Birkenhäger, WH; de Leeuw, PW; Ligthart, JJ; Smout, AJ, 1982) |
| "The comparative efficacy and effects on total body potassium of prazosin and polythiazide vs nadolol and polythiazide in the treatment of patients with mild to moderate essential hypertension unresponsive to diuretic alone were compared in an open, crossover trial involving 20 male patients." | 5.05 | A comparison of prazosin versus nadolol in combination with a diuretic. ( Kraut, J; Okun, R, 1984) |
| "The effects of propranolol and prazosin on plasma lipoproteins in patients with essential hypertension were evaluated according to a crossover protocol of two 8-week periods with a washout of 4 to 6 weeks." | 5.05 | Plasma lipid and lipoprotein changes in hypertensive patients treated with propranolol and prazosin. ( Franceschini, G; Gemma, G; Mantero, O; Montanari, G; Paralovo, A; Sirtori, CR; Suppa, G, 1982) |
| "We report the results of an observer blind crossover trial in 31 patients with essential hypertension comparing the hypotensive effect of four doses of prazosin and of hydralazine used as the third step of triple therapy and additional data on the efficacy of low dose combinations of these two drugs." | 5.05 | Hydralazine and prazosin in the treatment of hypertension. ( Barnes, JN; Drew, PJ; Sharman, VL; Vandenburg, MJ; Wright, P, 1983) |
| "Twenty-seven patients with uncontrolled hypertension (diastolic blood pressure greater than or equal to 95 mm Hg) receiving thiazide diuretics were treated with the addition of either propranolol (n = 10) or prazosin (n = 17)." | 5.05 | Comparison of blood pressure, plasma lipid and cardiac performance responses to prazosin versus propranolol in thiazide-treated hypertensive patients. ( Cutler, RE; Merkel, T; Misson, R, 1984) |
| "The antihypertensive action of prazosin and propranolol, as well their effect on serum lipid levels, were evaluated in a crossover study in 20 men with untreated mild to moderate hypertension in a general practice environment." | 5.05 | Changes in serum lipid levels during antihypertensive therapy. ( , 1984) |
| "The acute and chronic effects of fixed dosages of clonidine and prazosin on supine and upright blood pressure, the renin-angiotensin-aldosterone system, and plasma catecholamines were compared in 24 patients with essential hypertension." | 5.05 | Comparative antihypertensive and endocrinologic effects of clonidine and prazosin in patients with essential hypertension. ( Drayer, JI; Hubbell, FA; Rose, DE; Weber, MA, 1984) |
| "A randomized double-blind crossover trial was conducted in 20 patients with moderate to severe hypertension to compare the efficacy of labetalol, which combines alpha- and beta-adrenoceptor blocking properties, with that of metoprolol alone or in combination with prazosin." | 5.05 | On the combination of alpha- and beta-adrenoceptor blockade in hypertension. ( Gellatly, R; Hill, A; Mennie, BA; Stokes, GS, 1983) |
| "The effects of prazosin and propranolol on total serum cholesterol concentration, low-density lipoprotein and high-density lipoprotein cholesterol fractions, and serum triglyceride concentration were compared in a crossover study in 29 patients with mild to moderate essential hypertension." | 5.05 | Effects of prazosin and propranolol on serum lipids in patients with essential hypertension. ( Lowenstein, J; Neusy, AJ, 1984) |
| "Prazosin was compared with hydralazine in 39 patients (mean age 49 years), who were already on beta-blockade for arterial hypertension." | 5.05 | Peripheral vasodilatation in the treatment of hypertension. Prazosin compared with hydralazine in patients not responding to beta-receptor blockade. ( Fagerberg, SE; Frithz, G; Malmberg, L, 1982) |
| "48 patients with normal-renin essential hypertension were treated with prazosin alone or in combination with oxprenolol." | 5.05 | Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension. ( Farsang, C; Juhász, I; Kapocsi, J; Székács, B; Vajda, L, 1981) |
| "Prazosin is a post synaptic alpha adrenergic blocker effective in hypertension, whose hypotensive effect is unaccompanied by reflex tachycardia or hyperreninemia, nor by other evidence of increased sympathetic activity." | 5.05 | Prazosin depression of baroreflex function in hypertensive man. ( O'Connor, DT; Sasso, EH, 1982) |
| "Changes in blood pressure, plasma volume (PV) (125I-albumin space), extracellular volume (ECV) (82Br-space) and glomerular filtration rate (GFR) (51Cr-EDTA clearance) were measured in 12 patients with mild to moderate essential hypertension on placebo and during long-term treatment with prazosin." | 5.05 | The antihypertensive effect of prazosin on mild to moderate hypertension, changes in plasma volume, extracellular volume and glomerular filtration rate. ( McNair, A; Nielsen, PE; Rasmussen, K; Rasmussen, S, 1980) |
| "In order to investigate comparatively the effects of prazosin and atenolol on plasma lipid concentrations, 60 patients from two centres, presenting with arterial hypertension (diastolic 90-120 mmHg, systolic 160-200 mmHg), were allocated at random to one or the other of these drugs." | 5.05 | [Comparative study of the effects of prazosin and atenolol on plasma lipids of hypertensive patients]. ( Jaillard, J; Rouffy, J, 1985) |
| "The treatments of mild hypertension with atenolol and prazosin in occupationally active men and women were compared in a double blind cross-over with placebo." | 5.05 | Working ability and exercise tolerance during treatment of mild hypertension. II. A comparison between atenolol and prazosin medication. ( Green, KA; Lange Andersen, K; Ottmann, W; Piatkowski, W, 1985) |
| "After screening two local populations in the northern part of The Netherlands for hypertension, patients with a diastolic pressure (DP) between 95 and 120 mmHg were treated daily either with 50 mg hydrochlorothiazide or 100 mg atenolol." | 5.05 | A comparison of labetalol and prazosin combined with atenolol in non-responders to atenolol plus hydrochlorothiazide in uncomplicated hypertension. ( Donker, AJ; May, JF; Schuurman, FH; ten Berge, BS; van der Veur, E; Wesseling, H, 1985) |
| "The effects of prazosin and alphamethyldopa on blood lipids and lipoproteins were assessed in 20 patients with mild or moderate arterial hypertension." | 5.05 | Effects of prazosin and alphamethyldopa on blood lipids and lipoproteins in hypertensive patients. ( Feldstein, E; Hernández-Pieretti, O; Morillo, J; Pellicer, R; Silva, H; Urbina-Quintana, A; Velasco, M, 1985) |
| "In 20 patients with long-standing essential hypertension, a comparison was made in a randomized cross-over study of the effect of once and twice daily prazosin administration on blood pressure levels." | 5.05 | Prazosin once or twice daily? ( Hengeveld, WL; Schouten, JA; Westerman, RF, 1985) |
| "A comparative study of changes in plasma lipids, apo-A1 and apo-B under the effect of 2-week, 2-month and 6-month treatments with hydrochlorothiazide and pratsiol was conducted in 48 patients with arterial hypertension." | 5.05 | [Change in the spectrum of lipids and apoproteins A1 and B as affected by hypothiazide and pratsiol in patients with hypertension]. ( Metel'skaia, VA; Mustafaev, II; Oganov, RG; Perova, NV; Postol'nikov, SF, 1985) |
| "Prazosin hydrochloride, a new antihypertensive agent, is said to be of mild-to-moderate potency when used as a sole agent in mild-to-moderate hypertension and when used in conjunction with other agents in severe hypertension." | 5.04 | Prazosin-new hypertensive agent. A double-blind crossover study in the treatment of hypertension. ( Schirger, A; Sheps, SG, 1977) |
| " The cardiovascular responses to handgrip exercise have been studied in ten patients with uncomplicated essential hypertension in a randomized crossover study of propranolol and prazosin." | 5.04 | The effects of alpha- and beta-adrenergic receptor blockers on the pressure responses to isometric exercise in hypertensive patients. ( Blake, P; Gale, EV; Reuben, SR, 1979) |
| "Prazosin (Minipress; Pfizer), a new antihypertensive agent, was investigated in 24 outpatients with uncontrolled hypertension." | 5.04 | Prazosin in the therapy of uncontrolled hypertension. ( Lubbe, WF, 1977) |
| "Fourty-six men and 6 women aged 45 years and having arterial hypertension newly diagnosed at routine medical examinations were given out-patient antihypertensive treatment with prazosin, prazosin + hydrochlorothiazide, or prazosin + hydrochlorothiazide + clonidine." | 5.04 | Antihypertensive drug combinations: prazosin, hydrochlorothiazide and clonidine. ( Kontro, J; Kyöstilä, S; Mattila, MJ; Pitkäjärvi, T, 1977) |
| "The efficacy of prazosin was assessed in 21 patients with essential hypertension who failed to respond adequately to a combination of methyldopa and hydrochlorothiazide." | 5.04 | Prazosin in hypertension with and without methyldopa. ( Itskovitz, HD; Kochar, MS; Zeller, JR, 1979) |
| "To evaluate risk factors (hypertension, diabetes mellitus, and current tamsulosin, alfuzosin, terazosin, or doxazosin use) for intraoperative floppy iris syndrome (IFIS) in patients undergoing phacoemulsification cataract surgery." | 4.87 | Risk factors for intraoperative floppy iris syndrome: a meta-analysis. ( Chatziralli, IP; Sergentanis, TN, 2011) |
| "Terazosin (Hytrin; Abbott Laboratories, North Chicago, IL) is a new, selective alpha 1-adrenoceptor blocking agent used on once-a-day basis for therapy of mild-to-moderate hypertension." | 4.78 | Terazosin: a new alpha adrenoceptor blocking drug. ( Achari, R; Laddu, A, 1992) |
| "For various reasons, the alpha 1-receptor blocker prazosin has been used infrequently as initial therapy for hypertension." | 4.78 | Alpha-blocker therapy of hypertension. An unfulfilled promise. ( Kaplan, NM; Khoury, AF, 1991) |
| " In this article, doxazosin is reviewed for its efficacy in the treatment of severe essential hypertension and specific complications or conditions of mild or moderate essential hypertension, namely, left ventricular hypertrophy, hyperlipidemia, noninsulin-dependent diabetes mellitus, renal insufficiency, pheochromocytoma, chronic obstructive pulmonary disease, peripheral vascular disease, and smoking." | 4.78 | Efficacy of doxazosin in specific hypertensive patient groups. ( Taylor, SH, 1991) |
| "Terazosin is a new, selective, alpha 1-adrenoceptor antagonist which is structurally similar to prazosin and of similar therapeutic efficacy in the treatment of mild-to-moderate essential hypertension." | 4.77 | Terazosin: a new antihypertensive agent with favorable effects on lipids. ( Luther, RR, 1989) |
| " Drugs that enhance central alpha 2 activity, such as clonidine, guanfacine and the active metabolite of methyldopa, can significantly lower BP and are effective in the long-term control of hypertension, either alone or in combination with other drugs." | 4.77 | Alpha-adrenergic receptors and blood pressure control. ( Reid, JL, 1986) |
| "Prazosin, an orally active alpha-1 selective adrenergic antagonist, has been of value in treating patients with hypertension and congestive heart failure." | 4.76 | Alpha-adrenergic receptor blockade with prazosin. Consideration of hypertension, heart failure, and potential new applications. ( Colucci, WS, 1982) |
| " However, their therapeutic potential in the management of essential hypertension was not realized until prazosin, a highly selective alpha 1-adrenergic antagonist, became available." | 4.76 | Selective alpha 1-adrenergic antagonists: therapeutically relevant antihypertensive agents. ( Graham, RM, 1984) |
| "We treated C57BL/6NCrl female mice with the α1-adrenergic antagonist prazosin during pregnancy and analyzed the male and female offspring for endocrine and metabolic abnormalities." | 3.85 | Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy. ( Geissler, C; Harder, L; Herrmann, B; Kirchner, H; Koch, C; Lehnert, H; Mittag, J; Oelkrug, R; Oster, H, 2017) |
| " Systolic blood pressure, fasted plasma parameters, insulin sensitivity, plasma norepinephrine (NE), uric acid, and angiotensin II (Ang II) were determined following 9 weeks of treatment." | 3.80 | Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension. ( MacLeod, KM; McNeill, JH; Tran, LT, 2014) |
| "Terazosin was effective in lowering blood pressure when administered alone (in dosages of 1 to 80 mg/day) and when prescribed (in dosages of 1 to 20 mg/day) in combination with other antihypertensive agents." | 3.77 | The safety and efficacy of terazosin in the treatment of essential hypertension in blacks. ( Saunders, E, 1991) |
| "We investigated the contribution of the sympathetic tone to the hypertension induced by chronic administration of buthionine sulfoximine (BSO) and characterized this model in mice." | 3.76 | Role of sympathetic tone in BSO-induced hypertension in mice. ( Baca, Y; Moreno, JM; O'Valle, F; Payá, JA; Perez-Abud, R; Rodríguez-Gómez, I; Vargas, F; Wangensteen, R, 2010) |
| "A number of agents are now available to treat hypertension." | 3.76 | alpha 1-antagonists in the treatment of hypertension. ( Grimm, RH, 1989) |
| "Terazosin is a post-synaptic alpha 1-adrenoceptor antagonist with a similar pharmacodynamic profile to prazosin." | 3.76 | Terazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in essential hypertension. ( Monk, JP; Titmarsh, S, 1987) |
| "Doxazosin is a long-acting selective alpha 1-adrenoceptor antagonist structurally related to prazosin." | 3.76 | Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension. ( Brogden, RN; Young, RA, 1988) |
| "Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin." | 3.75 | Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. ( Belin de Chantemèle, EJ; Fulton, DJ; Marrero, MB; Mintz, J; Muta, K; Stepp, DW; Tremblay, ML, 2009) |
| " Prazosin injection produced hypotension and tachycardia in both groups (C=-43+/-3 mm Hg/98+/-16 bpm; SW=-61+/-5 mm Hg/115+/-32 bpm)." | 3.73 | Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious rats. ( Basso, LS; Becker, LK; de Souza, HC; Garcia, MR; Lopes, OU; Martins-Pinge, MC; Neto, RV; Zoccal, DB, 2005) |
| "Treatment of benign prostatic hyperplasia (BPH) with nonselective alpha1 antagonists such as terazosin, doxazosin, and prazosin results in blood pressure reduction due to vasodilation." | 3.71 | Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study. ( Chao, J; Chrischilles, E; Gilden, D; Kreder, KJ; Rubenstein, L; Shah, H, 2001) |
| "A novel model of hypertension recently developed in our laboratory shows that neonatal degeneration of capsaicin-sensitive sensory nerves renders a rat responsive to a salt load with a significant rise in blood pressure." | 3.70 | Antihypertensive mechanisms underlying a novel salt-sensitive hypertensive model induced by sensory denervation. ( Li, J; Wang, DH, 1999) |
| " Prazosin antagonized the pressor response to NE more effectively in the hypertension than in the control." | 3.69 | Characterization of the alpha-1 adrenoceptors in the mesenteric vasculature from deoxycorticosterone-salt hypertensive rats: studies on vasoconstriction, radioligand binding and postreceptor events. ( Kato, H; Kubota, S; Ozaki, S; Suzuki, S; Takata, Y, 1994) |
| " In these studies, we produced chronic NO blockade by oral administration of the NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME), which produced sustained hypertension and increased renal vascular resistance (RVR) in conscious rats." | 3.69 | Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension. ( Baylis, C; Engels, K; Qiu, C, 1994) |
| " The objective of this study was to examine short-term effects of cilazapril and prazosin therapy on insulin sensitivity assessed by a 15' test of insulin tolerance of obese hypertensive persons." | 3.69 | [The effect of cilazapril and prazosin on insulin sensitivity in patients with essential hypertension]. ( Cirić, J; Nesović, M; Tasić, N; Trbojević, B; Zarković, M, 1995) |
| "5 mg/kg) or Group 3, captopril (4 mg/kg), each followed by bleeding as in the group 1." | 3.69 | Insight into blood-pressure control in SHR via the response to acute hemorrhage: a spectral analysis approach. ( Akselrod, S; Cohen, S; Eliash, S; Oz, O, 1995) |
| " The effect of a 2-week treatment with nifedipine, captopril and prazosin upon glycaemia, serum insulin (IRI) and C-peptide (CP) following oral and intravenous glucose load were investigated in three groups, each including 10 non-diabetic patients with essential hypertension (h) and 10 hypertensive type 2 (non-insulin-dependent) diabetics (h + d), aged 32-63 years." | 3.69 | Effect of nifedipine, captopril and prazosin on secretory function of pancreatic beta-cells in hypertensive patients with type-2 (non-insulin-dependent) diabetes and in hypertensive non-diabetics. ( Czyzyk, A; Jasik, M; Kasperska-Dworak, A, 1996) |
| "The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP > or = 115 mmHg)." | 3.69 | Oral therapy with combined enalapril, prazosin and hydrochlorothiazide in the acute treatment of severe hypertension in Nigerians. ( Adigun, AQ; Afolabi, MA; Ajayi, AA; Ajayi, OE; Akintomide, AO; Balogun, MO, 1996) |
| "To evaluate the use and problems of alpha-receptor blockade with prazosin among patients in Nigeria with benign prostatic hyperplasia (BPH) who face a prolonged wait for a prostatectomy." | 3.69 | alpha-receptor blockade for benign prostatic hyperplasia: uses and problems in a developing country. ( Ogbonna, BC; Okeahialam, BN; Ramyil, VM, 1997) |
| "To study the effects of the selective neuropeptide Y (NPY) Y1 receptor antagonist BIBP 3226 in spontaneously hypertensive rats (SHR) in order to elucidate whether NPY function may be altered in the SHR and whether the NPY Y1 receptor plays a specific role in the maintenance of high blood pressure in this genetic form of hypertension." | 3.69 | Does the neuropeptide Y Y1 receptor contribute to blood pressure control in the spontaneously hypertensive rat? ( Edvinsson, L; Hedner, T; Sun, XY; Zhao, XH, 1997) |
| "To evaluate the effects of metyrosine (alpha-methyl-p-tyrosine), a catecholamine synthesis inhibitor, and alpha-blockade with prazosin or phenoxybenzamine on cardiovascular morbidity during surgery for pheochromocytoma." | 3.69 | Metyrosine and pheochromocytoma. ( Bransome, ED; Carr, AA; Prisant, LM; Steinsapir, J, 1997) |
| "Eighteen previously untreated primary hypertension patients were selected for therapy either with 50-250 mg/day metoprolol (n = 11) or with 3-20 mg/day prazosin (n = 8)." | 3.69 | Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension. ( Gretzer, I; Hjemdahl, P, 1997) |
| "To study potential cardiac alpha 1-adrenoceptor changes in the stage of established hypertension, [3H]prazosin binding characteristics and norepinephrine (NE) stimulated production of inositol phosphates in the ventricular tissue of spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto control rats (WKY) were determined." | 3.68 | Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats. ( Badia, A; Gascón, S; Ivorra, D; Vila, E, 1993) |
| "The effect of enalapril and terazosin on serum lipid profile was investigated in 36 patients with primary hypertension and hypercholesterolemia (total cholesterol 5." | 3.68 | [Effect of enalapril and terazosin on lipid metabolism in patients with essential arterial hypertension and accompanying hypercholesterolemia]. ( Hańczycowa, H; Jordanek, P; Jurga, M; Ponikowski, P; Rotter, A; Sebzda, T; Spring, A, 1993) |
| "In blood pressure (BP) reduction induced by gallopamil, hydralazine and prazosin in patients with essential hypertension a common trend was found in renal prostanoid production which included increased TxB2 excretion and/or augmented TxB2/6-keto-PGF1alfa ratio and, with the exception of response to prazosin, enhanced PGF2alfa excretion." | 3.68 | TxA2-PGI2-PGF2 alfa responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension. ( Fehér, J; Gachályi, B; Juhász, I; Székács, B, 1993) |
| "Prazosin is a selective peripheral alpha 1-adrenoceptor antagonist used in the treatment of hypertension and heart failure." | 3.68 | [Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases]. ( Bourget, P; Edouard, D; Fernandez, H; Frydman, R; Ribou, F, 1993) |
| "Secretion of insulin, glucagon, gastrin and pancreatic polypeptide (PP) at basal and test meal stimulation conditions were investigated in 17 patients with essential hypertension (EH) before and after 12 months of treatment with prazosin and in 10 healthy subjects." | 3.68 | [Effect of long term prazosin treatment on secretion of insulin, glucagon, gastrin, and pancreatic polypeptide in patients with essential hypertension]. ( Grzeszczak, W; Kokot, F; Wiecek, A; Zukowska-Szczechowska, E, 1993) |
| "The influence of prazosin treatment for 12 months on basal and LH-RH stimulated FSH, LH, estradiol and testosterone secretion and basal and chlorpromazine stimulated prolactin secretion was estimated in 15 male patients with essential hypertension." | 3.68 | [The effect of long-term prazosin treatment on plasma follitropin (FSH), lutropin (LH), prolactin, estradiol and testosterone concentration in male patients with essential hypertension]. ( Kokot, F; Wiecek, A; Zukowska-Szczechowska, E, 1993) |
| "Doxazosin, an alpha-adrenergic antagonist with potentially favourable effects on lipid status was evaluated in 25 otherwise healthy general practice patients with mild to moderate hypertension." | 3.68 | Combined effect of doxazosin and pindolol on blood pressure control and lipid concentrations in patients with essential hypertension selected from general practice. Hunter Hypertension Research Group. ( , 1992) |
| "The combination of nifedipine and prazosin was more successful in preventing myocardial damage in 16 patients with hypertension than was nifedipine alone in two other patients with hypertension." | 3.68 | Management of the cardiovascular manifestations of poisoning by the Indian red scorpion (Mesobuthus tamulus). ( Bawaskar, HS; Bawaskar, PH, 1992) |
| "Oral prazosin hydrochloride (2-20 mg/day) was administered to 38 patients with chronic congestive heart failure due to ischemic heart disease for 6-18 months." | 3.68 | Prazosin in chronic congestive heart failure due to ischemic heart disease. ( Antani, JA; Antani, NJ; Nanivadekar, AS, 1991) |
| "During three consecutive days of prazosin treatment in a patient with pheochromocytoma, urinary catecholamine metabolite levels were correlated with plasma renin activity." | 3.68 | Prazosin's effect in high renin hypertension complicating pheochromocytoma. ( Mager, A; Rechavia, E; Sagie, A; Sclarovsky, S; Strasberg, B, 1991) |
| "In vitro autoradiography was used to compare peripheral alpha-1 and alpha-2 adrenergic receptor binding in various tissues using [3H]prazosin and [3H]rauwolscine, respectively, in three models of experimental hypertension in rats." | 3.68 | Peripheral alpha-1 and alpha-2 adrenergic receptors in three models of hypertension in rats: an in vitro autoradiography study. ( Wilson, SK, 1991) |
| "The cardiovascular responses of 24 healthy young adult males with a parental history of hypertension and 24 males without a parental history of hypertension to an extended active-coping psychological stressor were compared under three drug conditions: placebo, the beta 1-blocking agent metoprolol, and the alpha 1-blocking agent prazosin." | 3.68 | Exaggerated sympathetic nervous system response to extended psychological stress in offspring of hypertensives. ( Ditto, B; Miller, SB, 1991) |
| " Doxazosin, a new selective alpha 1-inhibitor used in the treatment of hypertension, is compared with the established beta-blocker, atenolol." | 3.68 | The cost-benefit approach to pricing new medicines: doxazosin versus beta-blocker treatment in Sweden. ( Lindgren, B, 1990) |
| "The antihypertensive effects of the selective alpha 1-adrenoceptor antagonist, terazosin, in black patients with uncomplicated, mild to moderate essential hypertension were examined retrospectively in seven randomized, double-blind, placebo-controlled trials conducted in the United States." | 3.68 | Efficacy of terazosin in the treatment of essential hypertension in blacks. ( Achari, R; Glassman, HN; Klepper, MJ; Laddu, AR; Luther, RR; Maurath, CJ, 1990) |
| "The effects of terazosin, a new, selective, alpha 1-adrenoceptor antagonist, on the serum lipid levels were examined in 103 black patients with uncomplicated, mild to moderate essential hypertension in six randomized, double-blind, placebo-controlled trials conducted in the United States." | 3.68 | Effects of terazosin on serum lipid levels in hypertensive blacks. ( Achari, R; Glassman, HN; Klepper, MJ; Laddu, AR; Luther, RR; Maurath, CJ, 1990) |
| "As chronic hypertension shifts the lower limit of cerebral blood flow (CBF) autoregulation to higher pressure levels, we studied the effects of the angiotensin converting enzyme (ACE) inhibitor, perindopril on mean arterial pressure (mean BP), basal CBF, and CBF autoregulation in awake renovascular hypertensive (2 kidneys, 1 clip model) and spontaneously hypertensive rats (SHR)." | 3.68 | Effects of the angiotensin I converting enzyme inhibitor perindopril on cerebral blood flow in awake hypertensive rats. ( Atkinson, J; Bray, L; Capdeville, C; Lartaud, I; Muller, F, 1991) |
| " The selective 5-HT2 antagonist LY 53857 abolished the increase in MAP and the bradycardia elicited by 5-HT." | 3.68 | Vasopressin and autonomic mechanisms mediate cardiovascular actions of central serotonin. ( Alper, RH; Pérgola, PE, 1991) |
| "The effect of prazosin treatment on blood pressure, plasma HDL-cholesterol concentration, and apoprotein-AI/HDL (apoAI/HDL) kinetics was studied in 11 patients with mild hypertension." | 3.68 | Effect of prazosin treatment on HDL kinetics in patients with hypertension. ( Chen, YD; Hoffman, BB; Reaven, GM; Sheu, WH; Swislocki, AL, 1990) |
| " The pharmacokinetics of doxazosin, following a single oral dose (1 mg) and chronic oral dosing (doubling doses up to a maximum of 16 mg day-1), were studied in 18 patients with mild to moderate hypertension and stable renal function varying from normal to severely impaired." | 3.68 | The pharmacokinetics of doxazosin in patients with hypertension and renal impairment. ( Dewhurst, AG; Honeywell, R; Oliver, RM; Renwick, AG; Upward, JW; Waller, DG, 1990) |
| "The effects of caffeine on aortic smooth muscle contractility during hypertension were studied in SHR and WKY control rats." | 3.68 | In vitro caffeine induced aortic smooth muscle reactivity in rat. ( Bennett, T; Mangroo, T; Neves, M; Rahmani, MA, 1990) |
| "Prazosin (Minipress) monotherapy was given to 152 patients with essential hypertension for one year in a multi-center study involving 13 hospitals and university clinics." | 3.68 | [The anti-lipidemic effect of Minipress]. ( Dudás, M; Farsang, C; Földes, I; Iványi, J; Pados, G, 1990) |
| "In patients with essential hypertension, the vasodilator response in the forearm circulation to postjunctional alpha 1-adrenoceptor blockade with prazosin is enhanced." | 3.67 | Sympathetic nervous system in essential hypertension and antihypertensive response to alpha 2-adrenoceptor stimulation. ( Amann, WF; Bolli, P; Bühler, FR; Erne, P; Kiowski, W, 1984) |
| " Therefore, a study was designed to compare the efficacy and the effects on left ventricular function of hydrochlorothiazide, propranolol and prazosin in 13 patients with mild to moderate hypertension." | 3.67 | Monotherapy in mild to moderate hypertension: comparison of hydrochlorothiazide, propranolol and prazosin. ( Benowitz, N; Inouye, I; Loge, D; Massie, B; Simpson, P; Topic, N, 1984) |
| "Ten patients with essential hypertension who had no end-organ damage were treated with prazosin, starting with a dose of 1 mg/day." | 3.67 | Cardiovascular consequences of primary antihypertensive therapy with prazosin hydrochloride. ( Blaufox, MD; Lee, HB; Scharf, SC; Wexler, JP, 1984) |
| "A long-term follow-up study was carried out in 90 patients with moderate to severe hypertension to evaluate the effectiveness of prazosin given alone or as part of combined treatment with other antihypertensive agents." | 3.67 | Prazosin ('Peripress'): a long-term study. ( Melkild, A, 1984) |
| "The antihypertensive efficacy of prazosin was compared with that of a combination of prazosin and propranolol in 14 patients with essential hypertension." | 3.67 | Prazosin versus propranolol plus prazosin: a comparison in diuretic-treated hypertensive patients. ( Blumenthal, SS; Kalbfleisch, JH; Kochar, MS; Maierhofer, WJ, 1984) |
| "The selective alpha1-adrenergic antagonist prazosin has recently been recommended for the preoperative management of pheochromocytoma, but we have observed a hypertensive crisis in a patient with such a tumor, despite prazosin therapy." | 3.67 | Hypertensive crisis in prazosin-treated pheochromocytoma. ( Fitzgerald, GA; Knapp, HR, 1984) |
| "This study examined the effects of the serotonergic (5-HT2) antagonist ketanserin in sheep on haemodynamic responses to infused serotonin (5-HT), development of adrenocorticotrophin (ACTH)-induced hypertension, and the effect of ACTH on in vivo pressor responsiveness to 5-HT." | 3.67 | Serotonergic mechanisms and blood pressure in sheep. ( Coghlan, JP; Denton, DA; Mills, EH; Nelson, MA; Scoggins, BA; Spence, CD; Whitworth, JA, 1985) |
| "A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension." | 3.67 | Antihypertensive effects and pharmacokinetics of single and consecutive administration of doxazosin in patients with mild to moderate essential hypertension. ( Kaneko, Y; Miyajima, E; Miyakawa, T; Shionoiri, H; Takagi, N; Umemura, S; Yasuda, G; Yoshimura, H, 1987) |
| "To study the role of medullary alpha-adrenoceptors in hypertension, we compared specific binding of [3H]prazosin and [3H]clonidine in different brain regions of spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and normotensive Wistar-Kyoto rats (WKY)." | 3.67 | Decreased density of alpha 2-adrenoceptors in medulla oblongata of spontaneously hypertensive rats. ( Ashizawa, N; Hayashi, E; Nakayama, K; Tomita, T; Yamada, S, 1989) |
| "The current study was designed to explore the effects of peripherally administered alpha-adrenoceptor inhibiting drugs (either prazosin or yohimbine) in spontaneously hypertensive (SHR) and DOCA-salt hypertensive rats before the development of established hypertension, as well as to characterize changes induced by prazosin and/or yohimbine in the cardiac noradrenaline (NA) content that might be responsible for the development of hypertension in these strains." | 3.67 | Alpha-blockade on blood pressure and on cardiac noradrenaline content in SHR and DOCA-salt rats. ( Saiz, J; Sanchez, A; Torres, A, 1989) |
| "This study investigates concentration-effect relationships in nine patients who had essential hypertension treated with prazosin." | 3.67 | Predictability of antihypertensive responsiveness and alpha-adrenoceptor antagonism during prazosin treatment. ( Donnelly, R; Elliott, HL; Meredith, PA; Reid, JL, 1989) |
| "Thirteen patients with essential hypertension were treated with an alpha 1-adrenoceptor antagonist, terazosin (1 to 4 mg/day) for 12 months." | 3.67 | Hemodynamic and endocrinological effects of a new selective alpha 1-blocking agent, terazosin, in patients with essential hypertension. Results of long-term treatment. ( Mikawa, M; Sasayama, S; Takata, M; Tomoda, F; Yasumoto, K; Yoshida, K, 1989) |
| "The system release of prazosin confirms the good efficacy and tolerance of Alpress in the hypertension treatment." | 3.67 | [Efficacy, tolerance and incidence of risk factors of Alpress in the treatment of arterial hypertension]. ( Neimann, JL, 1989) |
| "This study evaluated the effect of prazosin in controlled mild hypertension and evaluated select metabolic changes that occurred with prazosin monotherapy." | 3.67 | Effect of prazosin treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. ( Chen, YD; Hoffman, BB; Reaven, GM; Sheu, WH; Swislocki, AL, 1989) |
| " This hypertension was managed with either prazosin (n = 29) or nifedipine (n = 17)." | 3.67 | Cyclosporine-associated hypertension in cardiopulmonary transplantation. The beneficial effect of nifedipine on renal function. ( Bateman, DN; Dark, JH; Kirk, AJ; Omar, I, 1989) |
| "A middle-aged woman with narcolepsy developed a pronounced exacerbation of cataplexy within 3 days of beginning treatment for hypertension with prazosin, an alpha 1-adrenoceptor antagonist." | 3.67 | Exacerbation of human cataplexy by prazosin. ( Aldrich, MS; Rogers, AE, 1989) |
| "The effects of selective alpha 1-adrenergic blockade with terazosin on blood pressure and cardiovascular pressor responsiveness were assessed in 17 subjects with mild to moderate essential hypertension (mean age, 48 +/- 2 [SEM] years)." | 3.67 | Alpha 1-adrenergic blockade and cardiovascular pressor responses in essential hypertension. ( Beretta-Piccoli, C; Ferrier, C; Weidmann, P, 1986) |
| "The pharmacokinetics of terazosin have been assessed in human volunteers, hypertensive patients, a limited number of elderly volunteers, and a small number of patients with congestive heart failure." | 3.67 | Pharmacokinetics of terazosin. ( Sonders, RC, 1986) |
| "Two hundred twenty-six patients with mild to moderate hypertension were treated with terazosin in an open, multicenter study to determine the drug's long-term efficacy and safety." | 3.67 | Long-term experience with terazosin for treatment of mild to moderate hypertension. ( Mersey, JH, 1986) |
| "The safety of terazosin, an effective agent for the treatment of hypertension, was assessed by analyzing data from 1,006 hypertensive patients who were enrolled in short-term and/or long-term studies." | 3.67 | Overall safety of terazosin as an antihypertensive agent. ( Glassman, HN; Jordan, DC; Luther, RR; Sperzel, WD, 1986) |
| "Since it is not known for certain which alpha-adrenergic receptors mediate renal vasoconstriction in human essential hypertension, we infused either doxazosin (n = 7) or yohimbine (n = 7) into the renal arteries of hypertensive subjects immediately prior to diagnostic angiography." | 3.67 | Role of alpha 1- and alpha 2-adrenergic receptors in the human hypertensive kidney. ( Birkenhäger, WH; de Bos, R; de Leeuw, PW; van Es, PN, 1987) |
| "Doxazosin, a selective alpha 1-inhibitor, was assessed in 34 patients with mild and moderate hypertension." | 3.67 | Doxazosin in the treatment of mild and moderate essential hypertension in general medical practice. ( van den Hogen, AL, 1988) |
| "The antihypertensive efficacy, lipid effects, and safety of doxazosin, a selective alpha 1-inhibitor for the reduction of coronary heart disease (CHD) risk in hypertensive patients, was assessed in a general medical practice setting." | 3.67 | Clinical experience with doxazosin in general medical practice. ( Rosenthal, J, 1988) |
| "Although the pathology of essential hypertension is still unclear, studies have shown that doxazosin, a selective alpha 1-inhibitor, is able to effectively control mild-to-moderate hypertension." | 3.67 | Control of coronary heart disease risk factors with doxazosin as monotherapy and in combination therapy. ( Rosenthal, J, 1988) |
| "The effects of selective alpha 1-adrenergic blockade with the agent terazosin on blood pressure and cardiovascular pressor responsiveness as related to major pressor factors were assessed in 17 patients with mild to moderate essential hypertension (mean age +/- s." | 3.67 | Cardiovascular effects of short-term selective alpha 1-adrenergic blockade with terazosin in patients with essential hypertension. ( Beretta-Piccoli, C; Ferrier, C; Weidmann, P, 1985) |
| "The effects of prazosin treatment on blood pressure and diabetic control were assessed in 22 patients with stable non-insulin-dependent diabetes mellitus and hypertension." | 3.67 | Effects of prazosin on blood pressure and diabetic control in patients with type II diabetes mellitus and mild essential hypertension. ( Levy, P, 1989) |
| " On this basis, functional and therapeutical regimen of regression of cardiac hypertrophy (prazosin, clonidine, nifedipine) are analyzed in concentric as well as in excentric hypertrophy in patients with arterial hypertension." | 3.67 | [Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects]. ( Strauer, BE, 1985) |
| "The acute and chronic haemodynamic effects of doxazosin were studied in 14 patients (10 males, four females) with essential hypertension, at rest supine and sitting and during 100 W bicycling exercise." | 3.67 | Acute and chronic haemodynamic effects of doxazosin in hypertension at rest and during exercise. ( Haugland, H; Lund-Johansen, P; Omvik, P, 1986) |
| "Arterial blood pressure and central hemodynamic changes were assessed in 44 patients with essential hypertension, uncontrollable by prazosin alone, after propranolol (anaprilin), celiprolol, clonidine (clofelin) or verapamil were added to the treatment schedule." | 3.67 | [Hemodynamic effect of a combination of prazosin with cardiac depressants in the treatment of hypertension]. ( Akopian, LM; Basem, AS; Ivleva, AIa; Krasnobaeva, GM; Moiseev, VS, 1988) |
| "As both hormonal and hemodynamic alterations similar to those occurring during exercise can also be produced in humans by hypoglycemia, the present study explored changes in hemodynamic parameters during hypoglycemia and the effects of the alpha 1-adrenergic blocker, prazosin, on those responses in hypertensive patients." | 3.67 | Vasodepressor effects of prazosin during insulin-induced hypoglycemia in hypertensive patients. ( Ijichi, H; Iyoda, I; Ochiai, M; Takahashi, H; Watanabe, T, 1985) |
| "Renal alpha-1 and alpha-2 adrenoceptors were characterized during the development of the spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto rats through Scatchard analysis of [3H]prazosin and [3H]yohimbine binding to kidney membrane preparations in an attempt to correlate biochemical changes with the reported functional changes occurring in hypertension development in the SHR." | 3.67 | Ontogeny of renal alpha-1 and alpha-2 adrenoceptors in the spontaneously hypertensive rat. ( Martínez-Sierra, R; Sáiz, J; Sánchez, A; Vidal, MJ, 1986) |
| "[3H]prazosin (PRAZ) and [3H]rauwolscine (RAUW) were used to examine the ontogeny of renal alpha 1- and alpha 2-adrenoceptors in the inbred Dahl hypertension-sensitive (S/JR) and -resistant (R/JR) rat." | 3.67 | The ontogeny of renal alpha 1- and alpha 2-adrenoceptors in the Dahl rat model of experimental hypertension. ( Juno, CJ; McCaughran, JA; O'Malley, E; Rosenthal, M, 1986) |
| "The aim of this study was to determine whether insulin sensitivity measured by the euglycaemic insulin clamp technique is lower in patients with primary hypertension than in matched healthy control subjects, and whether this sensitivity was affected after 12 weeks of antihypertensive treatment with the alpha 1-adrenoceptor blocking drug prazosin." | 3.67 | Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension. ( Berne, C; Lithell, H; Pollare, T; Selinus, I, 1988) |
| "Altogether 33 patients with arterial hypertension were investigated to study changes of left ventricular systolic phasic analysis, caused by prazosin therapy." | 3.67 | [Changes in myocardial function in patients with hypertension during treatment with minipress]. ( Akhmeteianova, EKh; Bakhshaliev, AB; Nechaeva, NI, 1988) |
| "In an open, non-comparative study, the effect of Prazosin, a selective and competitive inhibitor of alpha-adrenergic receptors, on blood pressure and lipid metabolism was studied in out-patients with hypertension." | 3.67 | [Prazosin in the treatment of hypertension: effect on lipid metabolism]. ( Dietz, S; Egger, H; Hariri, K; Hitzenberger, G; Kittler, E; Neumann, K; Niedrist, W; Nitsch-Fritz, R; Ravanelli, O; Sapinsky, H, 1987) |
| "Changes in plasma active and inactive renin and angiotensin II in response to tilt and intravenous frusemide were assessed in ten patients with essential hypertension, before treatment and again during chronic therapy with the alpha 1-adrenoceptor antagonist prazosin." | 3.67 | The effect of chronic prazosin therapy on the response of the renin-angiotensin system in patients with essential hypertension. ( Fulton, JD; Leckie, BJ; Malatino, LS; McAreavey, D; Morton, JJ; Murray, GD; Robertson, JI; Webb, DJ, 1987) |
| "To examine the relationships between the central and peripheral renin angiotensin system in normotensive Wistar Kyoto (WKY) rats, two-kidney, one-clip Goldblatt renovascular hypertension (RVH), spontaneously hypertensive rats (SHR), SQ 14225 (captopril) was administered intraventricularly (IVT) and intravenously (IV) in the alternative manner and their combination." | 3.67 | Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats. ( Itaya, Y; Kageyama, Y; Kondo, K; Matsukawa, S; Saruta, T; Suzuki, H, 1986) |
| "Therapeutic efficiency and hemodynamic effects of prazosin were examined in 42 patients with essential hypertension in the course of prolonged treatment." | 3.67 | [Long-term use of prazosin alone and combined with propranolol in patients with essential hypertension]. ( D'iakonova, EG; Erina, EV; Prokopova, TN, 1986) |
| " This study evaluated the therapeutic effect of titrated doses of prazosin, an alpha-adrenergic blocking agent, on systemic blood pressure and cerebral blood flow in elderly patients with chronic stable hypertension." | 3.67 | Antihypertensive therapy in the elderly. Effects on blood pressure and cerebral blood flow. ( Bonte, FJ; Cutler, RE; Devous, MD; Forland, SC; Kaplan, NM; Meese, R; Ram, CV, 1987) |
| "The metabolic effects of the alpha 1-adrenoceptor blocking drug prazosin was evaluated in 8 premenopausal women undergoing treatment for essential hypertension." | 3.67 | Glucose metabolism during long-term treatment with prazosin. ( Berne, C; Lithell, H; Waern, AU; Wibell, L, 1985) |
| "As part of the Veterans Administration cooperative studies on antihypertensive agents, systolic time intervals (STIs) were recorded before and after 2 or 4 weeks of treatment with hydrochlorothiazide (HCTZ) alone in 320 asymptomatic patients with mild to moderate hypertension." | 3.67 | Serial measurements of systolic time intervals during treatment with hydrochlorothiazide alone and combined with other antihypertensive agents. ( Freis, ED; Kyle, MC, 1985) |
| "The relative bioavailability of two different Prazosine preparations (Adversuten, VEB Arzneimittelwerk Dresden, GDR and Minipress, Pfizer GmbH, Karlsruhe, FRG) has been determined in 10 patients suffering from an essential hypertension by the cross-over test following a single oral application." | 3.67 | [Comparative study of the relative bioavailabilities of two prazosin preparations in patients with essential hypertension]. ( Faulhaber, HD; Günzel, R; Homuth, V; Prehm, C; Rostock, G; Unger, P, 1985) |
| "The effect of an 8-week monotherapy with propranolol and pratsiol on plasma lipid levels and apo-Al and apo-B, apoproteins of high- and low-density lipoproteins (HDLP, LDLP) was studied in 20 patients with second-stage essential hypertension." | 3.67 | [Effect of obzidan and pratsiol therapy on the blood plasma lipid profile and on the high- and low-density lipoprotein apoproteins in hypertension patients]. ( Metel'skaia, VA; Mustafaev, II; Oganov, RG; Perova, NV; Postol'nikov, SF, 1985) |
| "This report reviews the available evidence for and against the combined use of clonidine and prazosin in treating hypertension." | 3.67 | Interaction between clonidine and alpha blockers. ( Jounela, AJ; Kanniainen, E; Lilja, M, 1985) |
| "To elucidate the mechanism of action of prazosin in lowering the blood pressure, we studied the vascular pressor responsiveness to the infusion of norepinephrine and angiotensin II before and after prazosin in patients with essential hypertension." | 3.66 | Alpha adrenergic blockade by prazosin in therapy of essential hypertension. ( Anderson, RJ; Crumpler, CP; Hart, GR; Ram, CV, 1981) |
| "The combination of prazosin (3-21 mg/day) and oxprenolol (60-360 mg/day) was used to treat 25 pregnant women with severe essential hypertension and 19 women with the hypertension-oedema-proteinuria syndrome." | 3.66 | Combined alpha- and beta-adrenoceptor antagonism with prazosin and oxprenolol in control of severe hypertension in pregnancy. ( Hodge, JV; Lubbe, WF, 1981) |
| "Combined use of prazosin and beta-blockers in a hypertension clinic over a 3-year period was surveyed by means of a computerized record system." | 3.66 | Combined use of prazosin and beta-blockers in hypertension. ( Frost, GW; Jeremy, D; Lewis, RG; Mitchell, AS; Raftos, J; Stokes, GS; Thornell, IR, 1982) |
| "Seventeen patients with newly diagnosed hypertension, or with hypertension not optimally controlled by previous treatment, completed an open, noncomparative study on the effects of prazosin on plasma lipids." | 3.66 | Open assessment of the effect of prazosin on plasma lipids. ( Flax, JS; Havard, CW; Khokhar, AM, 1982) |
| "Patients with essential hypertension (n = 45) had significantly lower substance P plasma levels (13." | 3.66 | Evidence of decreased plasma substance P levels in human essential hypertension and influence of prazosin treatment. ( Faulhaber, HD; Görne, RC; Hartrodt, W; Homuth, V; Naumann, E; Oehme, P; Pfeiffer, D; Rathsack, R; Rostock, G, 1983) |
| "The disposition and effect of orally administered prazosin have been studied in eight women with hypertension which was uncontrolled by beta-adrenoceptor blockade during the last trimester of pregnancy." | 3.66 | Clinical pharmacological studies with prazosin during pregnancy complicated by hypertension. ( Butters, L; Low, RA; Reid, JL; Rubin, PC, 1983) |
| "26 patients with moderate hypertension and no signs of heart failure were treated with metoprolol, labetalol or prazosin." | 3.66 | The use of systolic time intervals in the evaluation of antihypertensive treatment with metoprolol, labetalol and prazosin. ( Buch, J; Rasmussen, S, 1983) |
| "After nearly 10 years in clinical use, prazosin has been shown in numerous studies worldwide to be an effective antihypertensive agent over the entire range of hypertension (mild, moderate, and severe), when used alone or in multitherapy." | 3.66 | Effectiveness of prazosin as initial antihypertensive therapy. ( Okun, R, 1983) |
| "Prazosin (Minipress; Pfizer), the first purely alpha-blocking antihypertensive agent, was used to treat 22 pregnant patients with moderately severe hypertension (diastolic blood pressure persistently above 95 mmHg at gestational ages ranging from 18 to 33 weeks)." | 3.66 | Prazosin and oxprenolol therapy in pregnancy hypertension. ( Davey, DA; Dommisse, J; Roos, PJ, 1983) |
| "Combined use of prazosin and propranolol was effective in preoperative management of three patients with norepinephrine(NE)-secreting pheochromocytoma (PHEO)." | 3.66 | Prazosin and propranolol in preoperative management of pheochromocytoma. ( Cubeddu, LX; Rosales, CB; Zarate, NA; Zschaeck, DW, 1982) |
| "The safety and effectiveness of prazosin hydrochloride combined with polythiazide for the treatment of hypertension was studied in four European countries by ten investigators." | 3.66 | Sustained antihypertensive response with Minizide: long-term follow-up in a multicentre study. ( Gordon, AJ; Woeltjen, AE, 1981) |
| " In four patients, whose hypertension was not controlled (supine blood pressure greater than 150--90 mmHg) by addition of 5 mg/day of prazosin to previous treatment (diuretics and beta-blockers), clonidine (150--450 microgram/day) led to control of hypertension in three cases." | 3.66 | Lack of antagonism in the antihypertensive effects of clonidine and prazosin in man. ( Andréjak, M; Coevoet, B; Comoy, E; De Fremont, JF; Fievet, P; Fournier, A; Makdassi, R, 1981) |
| "An open study was undertaken in 31 patients with moderate to severe hypertension to compare labetalol (a competitive antagonist of both alpha-adrenoreceptors and beta-adrenoreceptors) alone and in combination with a thiazide diuretic, with a combination of thiazide, beta-adrenergic blocking agent and the alpha-adrenoreceptor blocker prazosin." | 3.66 | Use of labetalol in moderate to severe hypertension. ( Hua, AS; Kincaid-Smith, P; Macdonald, I; Thomas, GW; Whitworth, JA; Woo, KT, 1980) |
| " Nine patients with essential hypertension were studied during administration of prazosin, hydralazine or placebo." | 3.66 | Unimpaired beta adrenergic responses during prazosin administration. ( Buzzeo, LA; Lowenstein, J; Steele, JM, 1979) |
| "5 mg of prazosin/day on blood pressure and on plasma renin activity were assessed in patients with essential hypertension and in healthy normotensive volunteer subjects." | 3.66 | Effect of prazosin on blood pressure and plasma renin activity in man. ( Arlart, I; Jaeger, H; Rosenthal, J, 1978) |
| "A case of angina pectoris worsened by prazosin is presented." | 3.66 | Exacerbation of angina pectoris by prazosin. ( Charness, ME; Fishman, JA; Robertson, D, 1979) |
| "In fifteen patients with hypertension, inadequately controlled during treatment with propranolol alone (mean dosage 333 mg/day), plasma volume (PV) and extracellular fluid volume (ECV) were determined." | 3.66 | Changes in plasma volume and extracellular fluid volume after addition of prazosin to propranolol treatment in patients with hypertension. ( Ibsen, H; Jensen, HA; Leth, A; Rasmussen, K, 1978) |
| "In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6 to 8 mg/day for 19 days before surgery." | 3.66 | Prazosin in the diagnosis and treatment of pheochromocytoma. ( Gill, DP; Wallace, JM, 1978) |
| "In a study of 10 patients suffering from hypertension the results showed that combination treatment with prazosin, cyclopenthiazide and a beta-blocker produced a significant fall in blood pressure." | 3.65 | Prazosin combined with thiazide diuretic and beta-blocker in the treatment of hypertension. ( Bhoola, R; Seedat, MA; Seedat, YK, 1977) |
| "The mechanism of action of prazosin hydrochloride, a new antihypertensive agent was studied in 14 patients with essential hypertension." | 3.65 | Physiologic evaluation of a new antihypertensive agent: prazosin HCl. ( Blaufox, MD; Bourgiognie, J; Koshy, MC; Mickley, D, 1977) |
| "We conducted an uncontrolled study of the efficacy of prazosin in the treatment of hypertension in 45 patients." | 3.65 | Prazosin alone and combined with a thiazide diuretic in the treatment of hypertension. ( Bhoola, R; Seedat, MA; Seedat, YK, 1977) |
| "The clinical usefulness of prazosin was investigated in 67 patients with mild to moderate essential hypertension for 6 to 12 weeks." | 3.65 | Open studies with prazosin in the treatment of essential hypertension. Prazosin Research Group in Japan. ( , 1977) |
| "Prazosin was used as an additional antihypertensive agent for treating 16 patients with hypertension and significant renal functional impairment." | 3.65 | Prazosin in the treatment of patients with hypertension and renal functional impairment. ( Bailey, RR; Little, PJ; Lynn, KL; Neale, TL, 1976) |
| "CARDIOVASCULAR RISK OF LEFT VENTRICULAR HYPERTROPHY: Because of the rhythmic, mechanical and ischemic risk related to it, the left ventricular hypertrophy (LVH) is considered to be a major independent risk factor for cardiovascular disease which should be screened for and treated early." | 2.70 | [Management of hypertensive patients with left ventricular hypertrophy]. ( Ambrosioni, E, 2002) |
| " No unknown adverse reactions were observed in either groups, and the drugs were shown to be highly safe." | 2.70 | [The efficacy and safety of terazosin and tamsulosin in patients with urinary disturbance accompanying prostatic hypertrophy]. ( Fujioka, T; Goto, Y; Isurugi, K; Katoh, T; Numasato, S; Obara, W; Omori, S; Suzuki, Y, 2001) |
| "Terazosin is a selective alpha1-adrenoceptor antagonist." | 2.69 | Effects of oral and intravenous terazosin and head-up tilt on blood pressure responses in patients with hypertension. ( Achari, R; Baroldi, P; Cavanaugh, J; Cohen, A; Hosmane, B; Linnen, P, 1998) |
| "nilvadipine or terazosin was administered for 2 weeks in a randomized crossover manner." | 2.69 | Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke. ( Abe, I; Fujishima, M; Hasuo, Y; Nishino, Y; Onaka, U; Setoguchi, M, 1998) |
| "Concern based on the reported short-term adverse effects of antihypertensive agents on plasma lipid and lipoprotein profiles (PLPPs) has complicated the therapy for hypertension." | 2.69 | Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. ( Cushman, WC; Freis, ED; Lakshman, MR; Materson, BJ; Reda, DJ, 1999) |
| "Treatment with prazosin caused a significant decrease in 24-h BP (136." | 2.69 | Interaction of alcohol and an alpha1-blocker on ambulatory blood pressure in patients with essential hypertension. ( Abe, H; Kawano, Y; Kojima, S; Omae, T; Takishita, S, 2000) |
| "A double-blind, randomized, placebo-controlled, multicenter study was conducted to describe the dose-response curve for terazosin on blood pressure." | 2.69 | The relationship between terazosin dose and blood pressure response in hypertensive patients. ( Achari, R; Bonacci, E; Hosmane, B; O'Dea, R, 2000) |
| "Treatment with prazosin GITS did not produce any statistically or clinically significant change in the metabolic parameters at the end of 24 weeks, while with nifedipine SR there was a significant increase in the serum LDL values at 24 weeks (p = 0." | 2.69 | Prazosin GITS vs sustained release nifedipine in patients with hypertension and abnormal lipid profile: a randomized, controlled, multicenter study. Madras Hypertension Study Group. ( Joglekar, SJ; Misra, KP; Mukherjee, S; Nanivadekar, AS, 1998) |
| "Treatment with prazosin GITS resulted in a favourable effect on the serum lipid profile at the end of 24 weeks (p = 0." | 2.69 | Prazosin GITS vs atenolol in patients with hypertension and normal lipid profile: a randomized, controlled multicenter study. Hyderabad Hypertension Study Group. ( Jaguste, V; Joglekar, SJ; Nanivadekar, AS, 1998) |
| "Treatment with prazosin GITS resulted in a favourable effect on serum triglycerides at the end of 8 weeks (p = 0." | 2.69 | A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group. ( Joglekar, SJ; Nanivadekar, AS, 1998) |
| "alpha-Blockers and calcium antagonists are commonly used in the treatment of hypertension, but few data are available concerning first dose or steady state (SS) hemodynamic and pharmacokinetic effects of these drugs when they are used in combination therapy." | 2.68 | Combined terazosin and verapamil therapy in essential hypertension. Hemodynamic and pharmacokinetic interactions. ( Johnston, W; Laddu, AR; Lenz, ML; Pool, JL; Taylor, AA; Varghese, A, 1995) |
| "Arterial hypertension is frequently associated with serum lipid abnormalities." | 2.68 | Factors affecting lipoprotein lipase in hypertensive patients. ( Annuzzi, G; D'Orta, G; Di Marino, L; Ferrara, LA; Lucarelli, C; Mancini, M; Marotta, T; Rossi, F; Russo, O, 1995) |
| " Terazosin, an alpha 1-adrenergic blocking agent, was given initially at the dosage of 1 mg daily." | 2.68 | Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension. ( Angeli-Greaves, M; Armas Padilla, MC; Armas-Hernández, MJ; Carvajal, AR; Guerrero Pajuelo, J; Hernández Hernández, R, 1996) |
| "Bunazosin Retard was associated with increases in GFR and ERPF in both normal and renally impaired groups; the increases were statistically significant in the renally impaired group (n = 14)." | 2.67 | Renal haemodynamic effects of bunazosin retard and prazosin in mild to moderately hypertensive patients with normal or moderately impaired renal function. ( Anderton, JL; Gill, M; Notghi, A, 1994) |
| "Prazosin was not recommended because of its low response rate." | 2.67 | Comparison of sublingual captopril, nifedipine and prazosin in hypertensive emergencies during hemodialysis. ( Huang, HW; Lin, CF; Lin, SL; Shiao, WY; Wu, SG; Yang, YH, 1993) |
| "Atenolol was successful by this definition in 51 percent of the patients, clonidine in 50 percent, hydrochlorothiazide in 46 percent, captopril in 42 percent, and prazosin in 42 percent; all these agents were superior to placebo (success rate, 25 percent)." | 2.67 | Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. ( Cushman, WC; Freis, ED; Fye, C; Gottdiener, J; Hamburger, RJ; Kochar, MS; Lakshman, R; Massie, BM; Materson, BJ; Reda, DJ, 1993) |
| " Doxazosin produced rightward shifts of the PE pressor dose-response curves but had no effect on responses to AII." | 2.67 | Vascular pressor responses in treated and untreated essential hypertension. ( Donnelly, R; Elliott, HL; Howie, CA; Reid, JL; Sumner, DJ, 1990) |
| "Both doxazosin and prazosin were well tolerated; seven patients (5." | 2.67 | A double-blind comparative study of doxazosin and prazosin in the treatment of essential hypertension. ( Fukiyama, K; Iimura, O; Ijichi, H; Inagaki, Y; Ishii, M; Kaneko, Y; Omae, T; Yagi, S; Yamada, K; Yoshinaga, K, 1991) |
| "Enalapril was increased to 10, 20 and 40 mg during the last 4 weeks, and prazosin was respectively increased to 4, 10 and 20 mg." | 2.67 | [The effect of enalapril and prazosin on mild to moderate hypertension in black South Africans]. ( Muntingh, GL; Venter, CP; Venter, HL, 1991) |
| "Doxazosin therapy was associated with opposite patterns of changes in fasting glucose, lipids and lipoproteins but only for serum triglyceride was difference between treatments significant." | 2.67 | Alpha-blocker therapy; a possible advance in the treatment of diabetic hypertension--results of a cross-over study of doxazosin and atenolol monotherapy in hypertensive non-insulin dependent diabetic subjects. ( Elkeles, RS; Feher, MD; Gelding, S; Henderson, AD; Poulter, C; Richmond, W; Sever, PS; Wadsworth, J, 1990) |
| "With doxazosin treatment, the mean supine and standing SBPs were reduced by 15 mmHg and 13 mmHg, respectively." | 2.67 | An evaluation of the efficacy and safety of doxazosin in the treatment of hypertension associated with renal insufficiency. ( Anderton, JL; Notghi, A, 1990) |
| " The overall effect is partly due to an increase in the apparent bioavailability of prazosin but may also reflect a synergistic effect on reducing peripheral vascular resistance." | 2.66 | Verapamil and prazosin in essential hypertension: evidence of a synergistic combination? ( Elliott, HL; Meredith, PA; Reid, JL, 1987) |
| " Starting at one mg, dosage was doubled every 2 weeks during a 10-week treatment period to a maximum dose of 16 mg once daily." | 2.66 | Alpha-1 adrenoceptor blockade with doxazosin in hypertension: effects on blood pressure and lipoproteins. ( Ames, RP; Kiyasu, JY, 1989) |
| "Terazosin was administered alone and in combination with other antihypertensive agents." | 2.66 | Clinical trials with terazosin. General methods. ( Glassman, HN; Luther, RR; Sperzel, WD, 1986) |
| "The short-term antihypertensive efficacy and safety of terazosin when administered with a diuretic were assessed in three randomized, double-blind, placebo-controlled studies." | 2.66 | Cumulative experience with terazosin administered in combination with diuretics. ( Rudd, P, 1986) |
| " Adverse effects were mild." | 2.66 | Efficacy and safety of intravenous terazosin in hypertensive patients. A preliminary report. ( Cohen, A, 1986) |
| "Because coronary heart disease is known to have many causes, primary preventive therapy must logically go beyond the relatively simple goal of lowering blood pressure." | 2.66 | Effects of oral antihypertensive agents on blood lipid levels. ( Leren, P, 1986) |
| " Another multicenter trial reported that doxazosin therapy was effective at low doses; 76% of those responders achieved controlled blood pressure at a mean dosage of 3." | 2.66 | Efficacy and safety of doxazosin in hypertension therapy. ( Hayduk, K, 1987) |
| " Patients were then maintained for another 4 weeks on the dosage necessary to control diastolic BP to less than or equal to 90 mm Hg (phase 3)." | 2.66 | A multicenter trial of doxazosin in West Germany. ( Rosenthal, J, 1987) |
| "Doxazosin is a once-daily, long-acting, selective alpha 1-adrenergic inhibitor that is effective for the treatment of essential hypertension." | 2.66 | Plasma lipid lowering effects of doxazosin, a new selective alpha1 adrenergic inhibitor for systemic hypertension. ( Pool, JL, 1987) |
| "Doxazosin is a competitive inhibitor of norepinephrine at alpha 1 adrenoceptors on vascular smooth muscle, where it blocks vasoconstriction." | 2.66 | Effects of alpha 1 inhibition on renal blood flow and sympathetic nervous activity in systemic hypertension. ( Wilner, KD; Ziegler, MG, 1987) |
| "Doxazosin is an effective hypotensive agent with beneficial effects on serum lipid levels." | 2.66 | A double-blind parallel trial to assess the efficacy of doxazosin, atenolol and placebo in patients with mild to moderate systemic hypertension. ( Black, H; Nash, DT; Reeves, RL; Schonfeld, G; Weidler, DJ, 1987) |
| "Doxazosin is an effective, well-tolerated, once-daily antihypertensive agent; it is comparable with terazosin but at a lower daily dosage." | 2.66 | Antihypertensive effects of doxazosin in systemic hypertension and comparison with terazosin. ( Hayduk, K; Schneider, HT, 1987) |
| "Felodipine is an effective antihypertensive agent when used with metoprolol." | 2.66 | Hormonal and blood pressure responses to tilting in beta-blocked essential hypertension treated with felodipine or prazosin. ( Jackson, B; Johnston, CI; McGrath, BP, 1987) |
| "Doxazosin monotherapy was effective in eight of 12 patients (66." | 2.66 | Doxazosin: a newly developed, selective alpha 1-inhibitor in the management of patients with pheochromocytoma. ( Miura, Y; Yoshinaga, K, 1988) |
| "Prazosin was better tolerated by the subjects and was preferred by 10 of the men." | 2.66 | Effect of atenolol or prazosin on maximal exercise performance in hypertensive joggers. ( Cullinane, EM; Nugent, AM; Sady, MA; Sady, SP; Thompson, PD, 1989) |
| "Treatment with prazosin and propranolol lowered sitting blood pressure to 127/89 mm Hg and 129/91 mm Hg, respectively (not significant), and did not alter the pressor response to smoking." | 2.66 | Assessment of the effects of alpha- and beta-blockade in hypertensive patients who smoke cigarettes. ( Alderman, MH; Laragh, JH; Mann, SJ; Pickering, TG, 1989) |
| "Doxazosin is a new quinazoline derivative that, like prazosin, has selectivity for alpha 1-receptors." | 2.66 | Clinical pharmacology of doxazosin in patients with essential hypertension. ( Caplan, N; Cubeddu, LX; Ferry, D; Fuenmayor, N, 1987) |
| " The plasma elimination half-life during the dose interval in these patients was 16." | 2.66 | A double-blind and cross-over comparison of once daily doxazosin and placebo with steady-state pharmacokinetics in elderly hypertensive patients. ( Hosie, J; Scott, MG; Scott, PJ, 1988) |
| "The antihypertensive effects and steady-state pharmacokinetics of doxazosin, as well as the bioequivalence of four dosage forms, were studied in 25 hypertensive patients." | 2.66 | Doxazosin in patients with hypertension. ( Conrad, KA; Fagan, TC; Falkner, FC; Lazar, JD; Lee, S; Mackie, MJ; Mayshar, PV; Souhrada, JF, 1988) |
| " Further measurements were made during a series of intensive study days, and the most important additional finding was a pharmacokinetic interaction that resulted in increased peak concentrations and bioavailability of prazosin." | 2.66 | The combination of prazosin and verapamil in the treatment of essential hypertension. ( Campbell, L; Elliott, HL; Meredith, PA; Reid, JL, 1988) |
| "We compared antihypertensive effects of monotherapy with pinacidil (N = 197) or prazosin (N = 204) in a randomized, parallel, double-blind dose-titration study in which hydrochlorothiazide or propranolol could be added for adverse events or lack of efficacy." | 2.66 | Vasodilator monotherapy in the treatment of hypertension: comparative efficacy and safety of pinacidil, a potassium channel opener, and prazosin. ( Goldberg, MR; Rockhold, FW; Sushak, CS; Thompson, WL, 1988) |
| " Using the conventional sphygmomanometer, there were no significant differences in blood pressures for the patients as a whole between the measurements during once-daily dosage (measured approximately 24 hours after the last administration of drug) and those during twice-daily dosage (measured approximately 12 hours after the last administration); but for both methods of administration, blood pressures were significantly lower than pre-treatment values." | 2.66 | Blood pressure monitoring for assessing the duration of action of antihypertensive treatment. ( Klein, RC; Tonkon, MJ; Weber, MA, 1987) |
| "Prazosin-treated patients whose initial fasting blood glucose was less than 110 mg/dl had 3." | 2.66 | Initial antihypertensive therapy. Comparison of prazosin and hydrochlorothiazide. ( Alderman, MH; Carroll, L; Davis, TK, 1986) |
| "Atenolol was withdrawn in those allocated to labetalol, and minoxidil was given only to men." | 2.65 | "Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic. ( Latham, L; Lorimer, AR; McAreavey, D; McLaren, AD; Ramsey, LE; Reid, JL; Robertson, JI; Robertson, MP; Weir, RJ, 1984) |
| "The possibility to apply impedance cardiography technique and individual statistical analysis based on Dixon's criterion to pharmacodynamic studies of single hydralazine ( apressine ), prazosine ( pratsiol ), endralazine ( mirethilan ), propranolol (obsidan) doses is discussed." | 2.65 | [Methodologic approach to individual evaluation of the pharmacodynamic effects of single doses of hydralazine, endralazine, prazosine and propranolol in hypertension patients]. ( Izotov, AI; Postol'nikov, SF; Vygodin, VA, 1984) |
| "Prazosin has been used as an antihypertensive drug in the treatment of 93 patients in Dunedin since 1971-1972, mainly those whose previous control was unsatisfactory." | 2.64 | Use of prazosin at the dunedin hypertension clinic controlled and open studies and pharmacokinetic observations. ( Bolli, P; Simpson, FO; Wood, AJ, 1977) |
| "Prazosin appears to be a potent and appropriate third agent." | 2.64 | Evaluation of beta blockade bendrofluazide, and prazosin in severe hypertension. ( Barritt, DW; Heaton, ST; Marshall, AJ; Pocock, J, 1977) |
| "Prazosin was better tolerated, with side effects tending to diminish with time." | 2.64 | Prazosin and clonidine for moderately severe hypertension. ( Hammond, JJ; Kirkendall, WM; Overturf, ML; Thomas, JC; Zama, A, 1978) |
| " Dosage can be progressively increased up to 30 mg/day." | 2.64 | [Prazosine: a new vasodilator used for treatment of hypertension (author's transl)]. ( Bret, M; Fillastre, JP; Godin, M, 1978) |
| " The dosage used was 1 mg TDS." | 2.64 | A phase II study of prazosin hydrochloride in hypertensive subjects. ( Paul, RR; Sharma, PL; Wahi, PL, 1976) |
| "Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients." | 2.44 | Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents. ( Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR, 2008) |
| "Extra-adrenal pheochromocytoma is a very rare entity, especially in the pediatric age group; the utility of the laparoscopic approach is not established in this population." | 2.44 | Laparoscopic resection of extra-adrenal pheochromocytoma--case report and review of the literature in pediatric patients. ( Al-Assiri, A; Kravarusic, D; Pinto-Rojas, A; Sigalet, D, 2007) |
| "Terazosin is a new, long-acting, selective, postsynaptic alpha 1-adrenergic receptor antagonist with a chemical structure similar to that of prazosin." | 2.38 | Terazosin: pharmacokinetics and the effect of age and dose on the incidence of adverse events. ( Achari, R; Laddu, AR; Somberg, JC, 1991) |
| "Doxazosin appears to inhibit the development of CHD on two fronts." | 2.38 | Effects of doxazosin on serum lipids: a review of the clinical data and molecular basis for altered lipid metabolism. ( Pool, JL, 1991) |
| "Doxazosin therapy was associated with a trend toward correcting the disturbances of lipoprotein metabolism characteristic of NIDDM." | 2.38 | Doxazosin therapy in the treatment of diabetic hypertension. ( Feher, MD, 1991) |
| " It is readily absorbed, with high bioavailability and a relatively long plasma half-life, neither of which property is influenced by age." | 2.38 | Clinical pharmacotherapeutics of doxazosin. ( Taylor, SH, 1989) |
| "The drug treatment of mild hypertension has been shown to afford protection against fatal and nonfatal strokes, congestive heart failure, progression to more severe levels of hypertension, and all-cause mortality, but not against the complications of coronary artery disease." | 2.38 | Pharmacologic basis for the use of doxazosin in the treatment of essential hypertension. ( Davey, MJ, 1989) |
| "Control of high blood pressure has failed to reduce the risk of atherosclerotic coronary heart disease (CHD)." | 2.38 | Review of the effects of doxazosin, a new selective alpha 1-adrenergic inhibitor, on lipoproteins in patients with essential hypertension. ( Nelson, EB; Pool, JL; Taylor, AA, 1989) |
| "Clonidine is a centrally acting alpha 2-agonist whose clinical use has often been limited by the dose dependent side effects of dry mouth and sedation, and the belief that it should be given three times per day." | 2.37 | Comparison of pharmacokinetics and pharmacodynamics of adrenoceptor agonists and antagonists as antihypertensive agents. ( Anavekar, SN; Conway, EL; Drummer, OH; Howes, LG; Jarrott, B; Louis, WJ; McNeil, JJ; Workman, B, 1987) |
| "Terazosin is a new long-acting, selective alpha 1-adrenergic antagonist." | 2.37 | Terazosin: a new long-acting alpha 1-adrenergic antagonist for hypertension. ( Eisen, G; Frishman, WH; Lapsker, J, 1988) |
| "Although drug treatment of hypertension is associated with improved survival and decreased vascular complications, drug compliance is a major problem in the control of hypertension." | 2.36 | Antihypertensive pharmacology. ( Freed, CR; Gerber, JG; Nies, AS, 1980) |
| "Treatment with prazosin restored iron homeostasis in SHRs." | 1.72 | Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats. ( Chang, H; Chang, YZ; Ding, W; Xin, Z; Zhang, D; Zhang, P, 2022) |
| "Hence, paragangliomas are occasionally misdiagnosed, and this results in unanticipated intraoperative hypertensive crisis." | 1.56 | Micturition syncope secondary to urinary bladder paraganglioma. ( Cherian, KE; Johnson, JT; Kapoor, N; Paul, TV, 2020) |
| "Pheochromocytomas are uncommon tumours that originate in chromaffin cells." | 1.56 | Ruptured functioning adrenal tumour, atypical presentation with renal colic and hypertension. ( Bashir, K; Elmesery, A; Elmoheen, A; Yousry, M, 2020) |
| "Prazosin was used as a reference compound, as quinazoline-based α1-adrenolytics may potentially exert unfavorable proapoptotic and necrotic effects." | 1.51 | Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist. ( Filipek, B; Kotańska, M; Kubacka, M; Marona, H; Mogilski, S; Nowak, B; Waszkielewicz, AM; Zadrożna, M, 2019) |
| "Tacrolimus is a calcineurin inhibitor primarily metabolized by CYP3A4 and secondarily by CYP3A5." | 1.42 | Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report. ( Gaies, E; Klouz, A; Lakhal, M; Salouage, I; Sassi, MB; Trabelsi, S, 2015) |
| "Hippadine is an alkaloid isolated from Crinum macowanii." | 1.40 | Effects of hippadine on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. ( Dietrich, D; Green, I; Mugabo, P; Philander, A; Raji, I, 2014) |
| " Physicians managing hypertensive patients should pay attention not only to adequate dosing and appropriate combination of drugs but also to health education and patient counselling." | 1.38 | Drug utilization and blood pressure control in a population where antihypertensives are given free: effect of policy change. ( Adedapo, AD; Adeleke, S; Okechukwu, R; Sikuade, O, 2012) |
| " In contrast, however, the results obtained from norepinephrine dose-response curves for EBA and ABA vascular rings in vitro did not provide evidence for loss of function of branchial artery alpha(1)-ARs in the salt-fed fish." | 1.34 | The effects of salt-induced hypertension on alpha1-adrenoreceptor expression and cardiovascular physiology in the rainbow trout (Oncorhynchus mykiss). ( Chen, X; Dombkowski, RA; Moon, TW; Olson, KR; Perry, SF, 2007) |
| "Hypertension was induced by blockade of nitric oxide synthesis." | 1.33 | Experimental orthostasis elicits sustained hypertension, which can be prevented by sympathetic blockade in the rat. ( Dézsi, L; Kollai, M; Mészáros, M; Monos, E; Raffai, G, 2005) |
| "Only clonidine treatment totally prevented the development of insulin resistance, and high-dose aspirin, known to prevent insulin resistance by inhibition of the activity of IkappaB kinase-beta, decreased the degree of insulin resistance by almost 70%." | 1.32 | Hypertension and insulin resistance are not directly related in obese dogs. ( Gokee, A; Rocchini, AP; Yang, JQ, 2004) |
| "Pretreatment with terazosin (10 mg/kg ip) significantly reduced the initial increase in MAP to 12 +/- 6 mmHg, whereas MAP for the last 45 min was superimposable on control values." | 1.32 | Sympathetic and angiotensin-dependent hypertension during cage-switch stress in mice. ( Brands, MW; Lee, DL; Webb, RC, 2004) |
| "Systemic hypertension is common in individuals with non-insulin-dependent diabetes (NIDD) and, in this population, markedly increases the risk for cardiovascular complications." | 1.31 | NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation. ( Mozaffari, MS; Patel, C; Schaffer, SW; Warren, BK, 2000) |
| "Treatment with reserpine resulted in gradual reduction in blood pressure and an improvement in ejaculatory dysfunction." | 1.31 | Autonomic studies in hypertensive patient with unusual sexual dysfunction: response to reserpine. ( Bhargava, B; Deepak, KK; Narang, R; Paudel, BH; Rai, PK; Saxena, S, 2000) |
| "Pheochromocytomas are functionally active, catecholamine-secreting tumours of chromaffin tissue." | 1.30 | [Intraoperative diagnosis of a multilocal pheochromocytoma]. ( Egelhof, J; Engelhardt, D; Fürst, H; Welte, M, 1997) |
| "Pheochromocytoma is a rare disease that may occur during pregnancy." | 1.30 | Pheochromocytoma in pregnancy manifesting hypertensive crisis induced by metoclopramide. ( Kinoshita, K; Seki, H; Takai, Y, 1997) |
| "Guanethidine treatment did not affect the arterial pressure or heart rate responses to aortic coarctation of intact rats but blunted the hypertensive response of SAD rats to the same values exhibited by intact rats." | 1.30 | Influence of sympathetic blockade on the acute hypertensive response to aortic constriction. ( Ballejo, G; Castania, JA; Fazan Júnior, R; Salgado, HC; Salgado, MC, 1997) |
| " Dose-response curves for NE-induced perfusion pressure, VO2, and lactate production in SHR were shifted to the left compared with WKY." | 1.30 | Altered muscle metabolism associated with vasoconstriction in spontaneously hypertensive rats. ( Colquhoun, EQ; Ye, JM, 1998) |
| " Chronic administration of propranolol (5 or 50 mg." | 1.29 | Effects of propranolol and atenolol on immobilization stress-induced hypertension and down-regulation of central beta-adrenoceptors in rats. ( Kigoshi, S; Muramatsu, I; Oda, Y; Takita, M, 1995) |
| "Felodipine was equally effective at both time points." | 1.29 | Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats. ( Janssen, BJ; Oosting, J; Struyker-Boudier, HA; Tyssen, CM, 1993) |
| "Pretreatment with prazosin which lowered the blood pressure near the level in normotensive Wistar Kyoto (WKY) rats, significantly shortened the thrombogenesis time, but it was still longer than that in WKY rats." | 1.29 | Hemodynamic effects on thrombogenesis and platelet aggregation in spontaneously hypertensive rats. ( Nakashima, M; Takiguchi, Y; Wada, K, 1993) |
| "In previously untreated rats, pretreatment with enalaprilat shifted the dose-response curve for the hypotensive effect of doxazosin to the left, indicating synergism." | 1.28 | A study of the interaction between the hypotensive actions of doxazosin and enalaprilat in anaesthetized rats. ( Marwood, JF; Stokes, GS; Tierney, G, 1992) |
| "Prazosin which is a selective alfa-1 blocking drug has a very good antihypertensive effect." | 1.28 | [Hemorheologic changes in patients with essential hypertension treated with prazosin]. ( Brkić, D; Gerc, V; Kamhi, J; Koblar, V, 1992) |
| " Therefore, after 4 weeks of washout with placebo (phase 1), doxazosin (dosage range from 1 to 16 mg, plus hydrochlorothiazide when necessary) was given to 11 essential hypertensive patients (6 M, 5 F, age range 34-63 years) for 8 weeks (phase 2) in order to achieve diastolic blood pressure values less than 90 mmHg; this dosage was then maintained for a further 20 weeks up to the end of the study (phase 3)." | 1.28 | Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin. ( Agabiti-Rosei, E; Beschi, M; Calebich, S; Castellano, M; Muiesan, G; Muiesan, ML; Rizzoni, D; Zulli, R, 1992) |
| " In both the SHR and WKY, chronic administration of terazosin did not influence vascular concentrations of 3-methylhistidine, a biochemical marker for contractile proteins and vascular medial hypertrophy." | 1.28 | Effect of alpha 1-adrenoceptor blockade on the development of hypertension in the spontaneously hypertensive rat. ( Frewin, DB; Head, RJ; Jonsson, JR, 1992) |
| " Head-up tilts in these rats did not produce orthostatic hypotension when performed either prior to or after acute dosing of prazosin (0." | 1.28 | Orthostatic hypotension occurs following alpha 2-adrenoceptor blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats. ( Brune, ME; DeBernardis, JF; Lee, JY; Warner, RB, 1992) |
| " After one dosage with a directly acting venodilator (nitroglycerin 5 mg s." | 1.28 | Compliance and reactivity of the peripheral venous system in chronic intermittent hemodialysis. ( Draaijer, P; Gladziwa, U; Kooman, JP; Leunissen, KM; Peltenburg, HG; Struyker-Boudier, HA; van Bortel, LM; van Hooff, JP; Wijnen, JA, 1992) |
| "The hypertension was totally reversed 5-7 days after cessation of DOCA-salt treatment, but the increase in RBF persisted, presumably as a result of renal hypertrophy." | 1.28 | Renal hemodynamics in canine DOCA-salt hypertension: effect of calcium channel blockade. ( Raich, PC; Zimmerman, BG, 1992) |
| "There is evidence that cardiac hypertrophy in spontaneously hypertensive rats (SHR) occurs before the development of hypertension." | 1.28 | Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension. ( Asano, H; Hashimoto, H; Ishikawa, K; Ito, T; Kondo, J; Okumura, K; Yoshino, M, 1992) |
| " Prazosin in combination with nadolol was found to level off the hyperprolactinemic effect of the latter without potentiating the reduction in the levels of follicle-stimulating, luteinizing, and testicular hormones which was observed during therapy with each drug alone." | 1.28 | [Effect of long-term treatment with prazosin and its combination with nadolol on the levels of blood hormones of the hypophyseal- gonadal system in patients with hypertension]. ( Akhmedova, ZG; Gumbatov, NB; Karaev, ME; Kasumova, FZ; Mamedova, RN; Mustafaev, II, 1992) |
| "Selected adverse events were evaluated from the combined randomized placebo-controlled clinical trials (once-a-day or twice-a-day; monotherapy or combination therapy) of terazosin in hypertensive patients." | 1.28 | Effect of age and dose on the incidence of adverse events in the treatment of hypertension in patients receiving terazosin. ( Hosmane, BS; Jordan, DC; Laddu, A; Maurath, CJ, 1992) |
| "Pretreatment with prazosin (0." | 1.28 | Quipazine-induced hypertension in anaesthetized cats is mediated by central and peripheral 5-HT2 receptors: role of the ventrolateral pressor area. ( Bouysset, F; Laubie, M; Schmitt, H; Vayssettes-Courchay, C; Verbeuren, TJ, 1991) |
| " The low oral bioavailability of SK&F 104078 did not appear to be due to high first-pass oxidative metabolism, since pretreatment of SHR with the suicide substrate inhibitor of cytochrome P-450, 1-aminobenzotriazole (ABT), did not result in increased oral efficacy." | 1.28 | Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats. ( Gombar, CT; Gutzait, L; Hieble, JP; Sulpizio, AC, 1990) |
| "Treatment with clonidine reduced both circadian variability of BP and HR and the awakening increase." | 1.28 | Modification of circadian blood pressure and heart rate variability by five different antihypertensive agents in spontaneously hypertensive rats. ( Janssen, BJ; Struyker-Boudier, HA; Tyssen, CM, 1991) |
| "Pretreatment with prazosin (10(-7)-10(-6) M) but not with yohimbine (10(-7) M), inhibited the noradrenaline-induced inositol phosphate formation indicating an alpha 1-adrenoceptor-mediated response." | 1.28 | Differences in inositol phosphate production in blood vessels of normotensive and spontaneously hypertensive rats. ( Macrae, IM; Reid, JL; Vila, E, 1991) |
| "Doxazosin, which has beneficial effects on haemodynamic factors and lipid metabolism, may be a suitable agent for treating these patients." | 1.28 | [The effect of doxazosin on blood pressure, lipids, fibrinogen and plasminogen activator inhibitor. A comparative study among smokers and non-smokers with essential hypertension]. ( Brusletto, B; Daae, LN; Holme, I; Kierulf, P; Syvertsen, JO; Westheim, A, 1991) |
| "Doxazosin, which has beneficial effects on haemodynamic factors and lipid metabolism, may be suitable for treating these patients." | 1.28 | Selective alpha 1 inhibition with doxazosin in hypertensive smokers and non-smokers: haemodynamic and metabolic effects. ( Brusletto, B; Daae, LN; Holme, I; Kierulf, P; Syvertsen, JO; Westheim, A, 1990) |
| "Doxazosin is a postsynaptic alpha-1 adrenoceptor blocker suitable for once a day treatment regime." | 1.28 | [Doxazosin for the treatment of arterial hypertension]. ( Buzzaccarini, F; Casolino, P; Giusto, M; Mozzato, MG; Pessina, AC; Rubino, N; Semplicini, A; Serena, L; Valle, R, 1990) |
| " Nicardipine in combination with atenolol or clonidine most effectively lowered blood pressure." | 1.28 | Nicardipine in combination with other antihypertensive drugs: calcium antagonist and prazosin have no additive antihypertensive effect? ( Jounela, AJ; Juustila, H; Kanniainen, E; Lilja, M; Pasanen, A, 1990) |
| "Although treatment of hypertension per se is important, blood pressure alone may not explain the course of the hypertrophic process." | 1.28 | Regression of left ventricular hypertrophy in hypertension. Effects of prazosin therapy. ( Corbett, J; Gonzalez, D; Kaplan, NM; Kulkarni, P; Ram, CV; Sunderajan, P; Taylor, A; Zachariah, NY, 1989) |
| " The elimination half-life in plasma was 10." | 1.28 | Single-dose and steady-state pharmacokinetics of doxazosin given in combination with chlorothiazide to hypertensive subjects. ( Conway, EL; Drummer, OH; Howes, LG; Louis, WJ; McNeil, JJ; Meng, L; Raymond, K, 1989) |
| " This indicates that small doses of prazosin (1-2 mg) cause significant in vivo shifts in the dose-response relationship of alpha adrenergic agonists." | 1.28 | Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy. ( Blaschke, TF; Eichler, HG; Ford, GA; Hoffman, BB; Swislocki, A, 1989) |
| " This doxazosin dosage reduced the diastolic blood pressure on average from 103 to 91 mmHg (P = 0." | 1.28 | Doxazosin, a new alpha-1-antagonist drug, controls hypertension without causing airways obstruction in asthma and COPD. ( Biernacki, W; Flenley, DC, 1989) |
| "02) and practically unchanged after metoprolol, at a time and at a drug dosage when only minor changes in blood pressure and serum lipids were detectable." | 1.28 | Adrenergic blocking agents and lipoprotein lipase activity. ( De Simone, B; Ferrara, LA; Leccia, G; Marotta, T; Rubba, P; Soro, S, 1989) |
| "The prazosin-related increase in the cholesterol ratio in vivo has been interpreted as a beneficial modification of this risk factor, but is not explained by our in vitro observations." | 1.27 | Comparison of in vitro and in vivo effects of prazosin on lipid metabolism. ( Kather, H; Säuberlich, P, 1984) |
| "With urapidil treatment, the decrease in vascular resistance was distributed throughout all circulations, with no change in heart rate or cardiac index." | 1.27 | Systemic and regional hemodynamic effects of acute and prolonged treatment with urapidil or prazosin in normotensive and spontaneously hypertensive rats. ( Frohlich, ED; Gallo, AJ; Kobrin, I; Natsume, T; Pegram, BL, 1984) |
| "Prazosin pretreatment and TAB prevented these effects." | 1.27 | Haemodynamic response to ketanserin in rabbits with Page hypertension: comparison with prazosin. ( Angus, JA; Wright, CE, 1983) |
| "Care must be taken in treating hypertension in diabetic patients because the choice of antihypertensive agent may worsen the diabetic state or its complications or cause additional health problems for the patient." | 1.27 | Treatment of hypertension in diabetic men: problems with sexual dysfunction. ( Lipson, LG, 1984) |
| "When prazosin was added to a beta-blocker/diuretic regimen, there was a further and statistically significant (p less than 0." | 1.27 | Effect of prazosin on blood pressure and plasma lipids in patients receiving a beta-blocker and diuretic regimen. ( Mauersberger, H, 1984) |
| " If patients failed to respond adequately at this dosage level, prazosin (0." | 1.27 | Timolol/bendrofluazide combination ('Prestim') in the treatment of poorly controlled hypertensive patients in general practice. ( Douglas-Jones, AP, 1984) |
| "In the spontaneously hypertensive rat (SHR), ketanserin and the ketanserin analogues R56413 and ritanserin were studied with regard to their ability to reduce the blood pressure in conscious rats and shift the dose-response curves for phenylephrine and serotonin (5-HT) in pithed rats after acute administration." | 1.27 | Antihypertensive effects of ketanserin in the spontaneously hypertensive rat: mode of action. ( Gradin, K; Hedner, T; Persson, B; Pettersson, A, 1985) |
| "In hypertensive cardiac hypertrophy, inotropic responsiveness of alpha and beta adrenergic stimuli is reduced." | 1.27 | Excitation-contraction coupling in hypertrophied myocardium. ( Fouad, FM; Hanna, MK; Khairallah, PA; Upsher, ME; Yoshida, K, 1985) |
| "Doxazosin was administered either short-term (20 or 200 mg/kg/day by gavage over 5 days) or long-term (0." | 1.27 | Effects of doxazosin on vascular collagen synthesis, arterial pressure and serum lipids in the spontaneously hypertensive rat. ( Chichester, CO; Rodgers, RL, 1987) |
| "Substance P (SP) plays an important role in central nervous and peripheral blood pressure regulation." | 1.27 | Substance P in human essential hypertension. ( Baumann, R; Enderlein, J; Faulhaber, HD; Naumann, E; Oehme, P; Rathsack, R; Rostock, G, 1987) |
| " Whereas the blood pressure reduction to acute administration of ketanserin was directly related to its ability to shift the dose-response curve of phenylephrine (alpha 1-adrenergic blockade), the same relationship was not apparent following chronic treatment with ketanserin." | 1.27 | Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat. ( Gradin, K; Hedner, T; Persson, B; Pettersson, A, 1988) |
| " However, dose-response curves for SHR characteristically displayed a depression of the maximum response as compared with those for WKY." | 1.27 | Renal alpha 1-adrenergic receptor response coupling in spontaneously hypertensive rats. ( Jeffries, WB; Pettinger, WA; Yang, E, 1988) |
| "Terazosin is a quinazoline antihypertensive agent that is chemically similar to prazosin." | 1.27 | Pharmacology of terazosin. ( Kyncl, JJ, 1986) |
| "Prazosin is a quinazoline derivative, which lowers blood pressure by selective alpha-1-receptor antagonism." | 1.27 | Clinical pharmacology and therapeutic role of prazosin and related alpha-adrenoceptor antagonists. ( Reid, JL; Vincent, J, 1986) |
| " The maximal antihypertensive response to CI-926 was unchanged with three consecutive days of oral dosing in the spontaneously hypertensive rat, whereas a first dose effect was noted with prazosin." | 1.27 | CI-926 (3-[4-[4-(3-methylphenyl)-1-piperazinyl]butyl]-2,4-imidazolinedione): antihypertensive profile and pharmacology. ( Bjork, FA; Cohen, DM; Coughenour, LL; Evans, DB; Major, TC; Mathias, NP; Mertz, TE; Olszewski, BJ; Ryan, MJ; Singer, RM, 1986) |
| "Systemic hypertension is a common clinical problem in the elderly." | 1.27 | Geriatric hypertension: antihypertensive therapy in coronary artery disease. ( Gonzalez, DG; Ram, CV, 1987) |
| " Labetalol and prazosin also significantly shifted the dose-response curve to the right for phenylephrine but not for angiotensin II." | 1.27 | Analysis of the mechanism underlying the vasodilator action of carvedilol in pithed spontaneously hypertensive rats. ( Akashi, A; Hashimoto, H; Kanda, A; Tanaka, M, 1988) |
| "Renal hypertrophy was also decreased significantly by cicletanine at a dose of 100 mg/kg." | 1.27 | Comparison of cicletanine with other antihypertensive drugs in SHR-SP models. ( Braquet, P; Clostre, F; Le Hegarat, M; Malherbe, E, 1988) |
| "Ketanserin is a new antihypertensive agent with affinity to serotonin (5-HT)2 receptors and at higher concentrations also to alpha 1-adrenoceptors." | 1.27 | Antihypertensive mechanism of action of ketanserin and some ketanserin analogues in the spontaneously hypertensive rat. ( Gradin, K; Hedner, T; Persson, B; Pettersson, A, 1985) |
| "Prazosin has been reported to reduce the hypotensive and/or bradycardic effect of clonidine in various animal models." | 1.27 | Prazosin partly blocks clonidine-induced hypotension in patients with essential hypertension. ( Farsang, C; Kapocsi, J; Vizi, ES, 1987) |
| " A sufficient antihypertensive effect in them resulted from the use of drug therapy at higher dosage than in SSP." | 1.27 | [Changes in the hemodynamics and cardiac function of hypertension patients on moderate limited consumption of table salt]. ( Bakhshaliev, AB; Gadzhiev, RF; Lan'shina, OE, 1988) |
| " No significant differences between the two phenotypes were observed in either the area under the plasma prazosin concentration-time curve, the terminal half-life or the first-dose effect of prazosin." | 1.27 | Lack of relationship between debrisoquine oxidation phenotype and the pharmacokinetics and first dose effect of prazosin. ( Lennard, MS; McGourty, JC; Silas, JH, 1988) |
| "Urgent hypertension is defined by severe elevations of blood pressure without associated end-organ damage." | 1.27 | Management of urgent hypertension: a comparison of oral treatment regimens in the emergency department. ( Catapano, MS; Marx, JA, 1986) |
| "Pharmacokinetic parameters of prazosin (t1/2, tmax, Cmax and AUC have been studied in 18 hypertensive patients with varying degrees of chronic renal failure (serum creatinine ranging from 1." | 1.27 | A pharmacokinetic study of prazosin in patients with varying degrees of chronic renal failure. ( Gordts, J; Lameire, N, 1986) |
| "Prazosin has been successfully used in the treatment of hypertension for more than 10 years." | 1.27 | Clinical pharmacology of selective alpha blockers. Hemodynamics and effects on lipid levels. ( Elliott, HL; Meredith, PA; Reid, JL; Vincent, J, 1987) |
| "Initially, the pharmacologic treatment of hypertension consisted mostly of thiazide diuretics, since they were the only agents generally available that were well-tolerated by most patients." | 1.27 | Lipids and hypertension. Implications of new guidelines for cholesterol management in the treatment of hypertension. ( Grimm, RH; Hunninghake, DB, 1986) |
| " Only a few side-effects were reported and these occurred during the first 4 weeks whilst prazosin dosage was being adjusted." | 1.26 | Combined antihypertensive therapy: vasodilatation using prazosin in combination with beta-adrenoceptor blockers and diuretics. ( Urban Waern, A, 1980) |
| "Prazosin is considered to be a useful anti-hypertensive agent especially in combination with thiazides and/or beta blockers." | 1.26 | Prazosin in general practice. ( Musgrove, JP, 1981) |
| " Atropine blocked the pressor responses to norepinephrine and shifted the dose-response curve for norepinephrine to the right to a similar extent in spontaneously hypertensive and Wistar-Kyoto rats." | 1.26 | Studies on the hypotensive response to atropine in hypertensive rats. ( Abraham, S; Cantor, EH; Spector, S, 1981) |
| "Clonidine was given in doses of 0." | 1.26 | Clonidine and prazosin effects in hypernoradrenergic vasodilator-treated and beta-blocker-treated patients. ( Mitchell, HC; Pettinger, WA, 1981) |
| "Among seven patients with Raynaud phenomenon, we have only a good result in one case (Buerger disease) and two cases with a little increase of the fingertips blood flow." | 1.26 | [Alpha blockers and microcirculation (author's transl)]. ( Cloarec, M; Dumas, JR; Graisely, B; Perdriset, G, 1981) |
| "Prazosin was the result of an attempt to find a directly acting vasodilator drug with little or no effect on cardiac output, renin and salt and water metabolism." | 1.26 | The pharmacology of prazosin, an alpha 1-adrenoceptor antagonist and the basis for its use in the treatment of essential hypertension. ( Davey, MJ, 1982) |
| " Chronic administration results in a decrease in total peripheral resistance and blood pressure at rest and during exercise." | 1.26 | Haemodynamic effects of alpha-receptor blockade during acute administration and chronic treatment. ( Rasmussen, K, 1982) |
| "1." | 1.26 | Orthostatic hypotension after the first administration of prazosin in hypertensive patients: role of the plasma volume. ( Hlede, M; Palatini, P; Palù, CD; Pessina, AC; Semplicini, A, 1981) |
| "Prazosin kinetics were studied after single doses (intravenous and oral, 0." | 1.26 | Prazosin kinetics in hypertension. ( Grahnén, A; Haglund, K; Lindström, B; Seideman, P; von Bahr, C, 1981) |
| " The dosage was increased, as necessary, by 1 tablet every 2 weeks to a maximum of 4 tablets daily to provide an adequate blood pressure response." | 1.26 | Treatment of Essential hypertension with single daily doses of a prazosin-polythiazide combination: a multicentre study with Minizide. ( Gordon, AJ; Woeltjen, AE, 1981) |
| "Prazosin absorption was not altered in patients with impaired renal function, and there is no cumulation of the drug when given repeatedly to patients with impaired renal function." | 1.26 | Prazosin kinetics and effectiveness in renal failure. ( Affrime, MB; Hobbs, D; Lowenthal, DT; Martinez, EW; Onesti, G; Twomey, TM, 1980) |
| "Prazosin kinetics were studied in 8 hypertensive patients (4 male and 4 female) with normal renal function." | 1.26 | Prazosin kinetics in essential hypertension. ( Chau, NP; Flouvat, BL; Le Roux, E; Safar, ME, 1980) |
| "Prazosin was give for 10 to 14 days to eight hypertensive patients on a fixed intake of dietary salt." | 1.26 | Physiologic mechanisms opposing the hemodynamic effects of prazosin. ( Horwitz, D; Izzo, JL; Keiser, HR, 1981) |
| "Prazosin is an effective hypotensive agent, used alone or in combination, in most patients with hypertension of all degrees of severity." | 1.26 | Prazosin in hypertension. Part I. Clinical experience in 100 patients. ( Brocklehurst, JE; Turner, AS; Watson, OF, 1977) |
| "Prazosin did not increase the ANA incidence in patients on or off various drug combinations including beta blockers and diuretics." | 1.26 | Influence of prazosin on the development of antinuclear antibodies in hypertensive patients. ( Booth, RJ; Bullock, JY; Wilson, JD, 1979) |
| "Prazosin appears to be a suitable substitute for hydralazine as an effective vasodialator if thiazides plus propranolol or thiazides plus reserpine or alpha-methyldopa are not effective." | 1.26 | Propranolol and newer antihypertensive drugs in the management of hypertension. ( Moser, M, 1979) |
| " In contrast, BL-5111, an antihypertensive agent similar in chemical structure and shown in previous studies to be slightly less potent than prazosin but with appreciably less alpha-adrenergic receptor antagonist activity, had no effect on blood pressure at 12 hours after dosing (1 and 2 mg/kg po)." | 1.26 | Comparative first dose effects of prazosin and tiodazosin (BL-5111) in spontaneously hypertensive rats. ( Buyniski, JP; Florczyk, AP; Roebel, LE, 1979) |
| " The enhanced antihypertensive effect of prazosin in renal failure appears to reflect changes in the bioavailability or distribution of the drug, which result in higher drug concentrations for a given dose." | 1.26 | Responsiveness to prazosin in renal failure. ( Frost, GW; MacCarthy, EP; Monaghan, JC; Stokes, GS, 1979) |
| "(i) Prazosin is an effective and useful antihypertensive agent, best used with a diuretic and a beta-blocker." | 1.26 | Initial experience with prazosin in New Zealand. A multicentre report. New Zealand Hypertension Study Group. ( , 1977) |
| "5." | 1.26 | A study of the use of prazosin in hypertensive patients in Korea. ( Kim, JS, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 727 (66.33) | 18.7374 |
| 1990's | 272 (24.82) | 18.2507 |
| 2000's | 64 (5.84) | 29.6817 |
| 2010's | 25 (2.28) | 24.3611 |
| 2020's | 8 (0.73) | 2.80 |
| Authors | Studies |
|---|---|
| Russell, RK | 1 |
| Press, JB | 1 |
| Rampulla, RA | 1 |
| McNally, JJ | 1 |
| Falotico, R | 1 |
| Keiser, JA | 1 |
| Bright, DA | 1 |
| Tobia, A | 1 |
| McCarthy, JR | 1 |
| Zimmerman, MB | 1 |
| Trepanier, DL | 1 |
| LeTourneau, ME | 1 |
| Wiedeman, PE | 1 |
| Whitten, JP | 1 |
| Broersma, RJ | 1 |
| Shea, PJ | 1 |
| Wiech, NL | 1 |
| Huffman, JC | 1 |
| Campbell, SF | 1 |
| Davey, MJ | 5 |
| Hardstone, JD | 1 |
| Lewis, BN | 1 |
| Palmer, MJ | 1 |
| Winters, G | 1 |
| Sala, A | 1 |
| Barone, D | 1 |
| Baldoli, E | 1 |
| Turner, S | 1 |
| Myers, M | 1 |
| Gadie, B | 1 |
| Nelson, AJ | 1 |
| Pape, R | 1 |
| Saville, JF | 1 |
| Doxey, JC | 1 |
| Berridge, TL | 1 |
| Honkanen, E | 2 |
| Pippuri, A | 1 |
| Kairisalo, P | 1 |
| Nore, P | 1 |
| Karppanen, H | 3 |
| Paakkari, I | 2 |
| Jain, KS | 1 |
| Bariwal, JB | 1 |
| Kathiravan, MK | 1 |
| Phoujdar, MS | 1 |
| Sahne, RS | 1 |
| Chauhan, BS | 1 |
| Shah, AK | 1 |
| Yadav, MR | 1 |
| Felippe, ISA | 1 |
| Zera, T | 1 |
| da Silva, MP | 1 |
| Moraes, DJA | 1 |
| McBryde, F | 1 |
| Paton, JFR | 1 |
| Chang, H | 2 |
| Zhang, D | 1 |
| Xin, Z | 1 |
| Zhang, P | 1 |
| Ding, W | 1 |
| Chang, YZ | 1 |
| Ohyama, K | 1 |
| Hori, Y | 1 |
| Sugiura, M | 1 |
| Johnson, JT | 1 |
| Cherian, KE | 1 |
| Kapoor, N | 1 |
| Paul, TV | 1 |
| Elmoheen, A | 1 |
| Yousry, M | 1 |
| Elmesery, A | 1 |
| Bashir, K | 1 |
| Cartwright, C | 1 |
| Ucciferro, P | 1 |
| Anastasopoulou, C | 1 |
| Jiang, C | 1 |
| Jiang, X | 1 |
| Wang, X | 2 |
| Shen, J | 1 |
| Zhang, M | 1 |
| Jiang, L | 1 |
| Ma, R | 1 |
| Gan, T | 1 |
| Gong, Y | 1 |
| Ye, J | 1 |
| Gao, W | 1 |
| Farshi, A | 1 |
| DalirAkbari, N | 1 |
| Zomorrodi, A | 1 |
| Khalili, M | 1 |
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| Reinikainen, P | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886] | 8 participants (Anticipated) | Interventional | 2021-06-08 | Recruiting | |||
| The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury[NCT03924388] | 46 participants (Anticipated) | Interventional | 2020-02-01 | Not yet recruiting | |||
| Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923] | 8 participants (Anticipated) | Interventional | 2021-12-31 | Recruiting | |||
| Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093] | 20 participants (Anticipated) | Interventional | 2021-11-29 | Recruiting | |||
| [NCT00693199] | 360 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| The Effects of Systemic Alfuzosin and Tamsulosin Hydrochloride on Choroidal Thickness and Pupil Diameter Sizes in Cases With Benign Prostatic Hyperplasia[NCT03144596] | Phase 4 | 63 participants (Actual) | Interventional | 2015-10-29 | Completed | ||
| Influence of the Autonomic Nervous System on Endothelial Function as an Acute Response to Exercise in Hypertensive Individuals: a Randomized Double-blind Protocol Study[NCT04371757] | 39 participants (Anticipated) | Interventional | 2020-04-30 | Recruiting | |||
| Effects of Nebivolol on Microvascular Perfusion in the Skeletal Muscles During Exercise in Hypertensive Patients[NCT01501929] | Phase 4 | 32 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Endothelial cell (EC) was collected after a 20-guage angiocatheter was inserted into the contralateral forearm vein under sterile conditions. Three J-shaped vascular guidewires (St. Jude, St. Paul, MN) were advanced sequentially into the vein up to 10 cm. Endothelial cells were collected by gentle abrasion and placed into a dissociation buffer (0.5% bovine serum albumin, 2mM EDTA, and 100 ug/ml heparin in PBS). Endothelial cells were recovered from the tips of guide wires by repeated washing into collection tubes and subsequent centrifugation. EC were incubated with monoclonal antibodies against the polyclonal antibodies against NADPH oxidase p47 subunit. The intensity of staining was measured using fluorescence microscopy. (NCT01501929)
Timeframe: 12 weeks
| Intervention | Ratio human to HUVEC p47Phox expression (Mean) |
|---|---|
| Metoprolol | 0.47 |
| Nebivolol | 0.44 |
Microvascular perfusion of skeletal muscle were measured during handgrip at 20 cycle per minute after 12 weeks of metoprolol, and after 12 weeks of nebivolol (NCT01501929)
Timeframe: 12 weeks
| Intervention | video intensity units/ second (Median) |
|---|---|
| Metoprolol | 43.938 |
| Nebivolol | 74.584 |
93 reviews available for prazosin and Blood Pressure, High
| Article | Year |
|---|---|
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age | 2008 |
Risk factors for intraoperative floppy iris syndrome: a meta-analysis.
Topics: Adrenergic alpha-1 Receptor Antagonists; Diabetes Complications; Doxazosin; Humans; Hypertension; In | 2011 |
Advances in the design and synthesis of prazosin derivatives over the last ten years.
Topics: Adrenergic alpha-1 Receptor Antagonists; Antihypertensive Agents; Drug Design; Humans; Hypertension; | 2011 |
Combination therapy as first-line treatment of arterial hypertension.
Topics: Antihypertensive Agents; Atenolol; Captopril; Diltiazem; Drug Therapy, Combination; Humans; Hydrochl | 2002 |
Laparoscopic resection of extra-adrenal pheochromocytoma--case report and review of the literature in pediatric patients.
Topics: Abdominal Neoplasms; Adolescent; Adrenergic alpha-Antagonists; Catecholamines; Female; Humans; Hyper | 2007 |
[Progress in the studies of alpha1-adrenoceptor blocker for concurrent benign prostatic hyperplasia and hypertension].
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Huma | 2007 |
[Bases of pharmacological therapy of essential hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Antihypertensive Agents; Captopril; Clonidine | 1980 |
[Beta and alpha-adrenoceptor blockers in the planning of anti-hypertensive therapy: recommendations for general practice].
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Biological Availability; | 1981 |
Prazosin: a review of clinical experience in hypertension.
Topics: Adrenergic beta-Antagonists; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Diu | 1981 |
Alpha-adrenergic receptor blockade with prazosin. Consideration of hypertension, heart failure, and potential new applications.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Child; Drug Tolerance; Heart Failure; H | 1982 |
Pharmacokinetic and dynamic aspects of alpha-adrenoceptor blockade in hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Biological Availability; Blood Proteins; Brain; Dose-Response | 1982 |
Hypertension--drug management.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Captopril; Diaz | 1982 |
The role of alpha-adrenoceptor blockade in the treatment of hypertension.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Indoramin; Prazosin; Receptors, Adrenergic, alph | 1983 |
Adrenergic regulation of renin release and effects on angiotensin and aldosterone.
Topics: Adrenergic beta-Antagonists; Aldosterone; Angiotensin II; Animals; Dinoprostone; Dogs; Electric Stim | 1983 |
Alpha-adrenergic blockade in the treatment of essential hypertension.
Topics: Adrenergic alpha-Antagonists; Biomechanical Phenomena; Hemodynamics; Humans; Hypertension; Indoramin | 1983 |
Selective alpha 1-adrenergic antagonists: therapeutically relevant antihypertensive agents.
Topics: Adrenergic alpha-Antagonists; Ethanolamines; Humans; Hypertension; Indoramin; Labetalol; Prazosin; R | 1984 |
Review of the use of alpha-adrenoceptor antagonists in hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Dose-Response Relationship, Drug; Humans; | 1984 |
Central and peripheral blockade of the sympathetic nervous system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; | 1984 |
Role of alpha adrenoceptors in hypertension and in antihypertensive drug treatment.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Azepines; | 1984 |
Alpha-adrenergic receptor subtypes.
Topics: Animals; Binding, Competitive; Clonidine; Dihydroergotoxine; Epinephrine; Heart Rate; Humans; Hypert | 1980 |
Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure.
Topics: Adrenergic alpha-Antagonists; Blood Pressure; Cardiovascular Diseases; Clinical Trials as Topic; Hea | 1983 |
Studies on the effect of prazosin on blood pressure and serum lipids in Japanese hypertensive patients.
Topics: Blood Pressure; Cholesterol; Drug Evaluation; Humans; Hypertension; Japan; Lipids; Pindolol; Prazosi | 1984 |
Drug systems approach to hypertension.
Topics: Captopril; Clonidine; Drug Combinations; Drug Therapy, Combination; Guanethidine; Humans; Hydralazin | 1984 |
Hypertensive crisis.
Topics: Antihypertensive Agents; Brain Diseases; Cerebrovascular Disorders; Clonidine; Coronary Disease; Dia | 1984 |
Anti-hypertensive drugs in the pregnant patient.
Topics: Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Diuretics; Female; Fetus; Furosemide | 1980 |
Antihypertensive pharmacology.
Topics: Adolescent; Adult; Antihypertensive Agents; Clonidine; Diazoxide; Diuretics; Guanethidine; Humans; H | 1980 |
[Therapy of essential arterial hypertension. III].
Topics: Antihypertensive Agents; Humans; Hydralazine; Hypertension; Minoxidil; Prazosin; Reserpine; Vasodila | 1980 |
[Arterial hypertension, III. Antihypertensive therapy (1). Diuretics].
Topics: Antihypertensive Agents; Diazoxide; Diuretics; Humans; Hydralazine; Hypertension; Mineralocorticoid | 1980 |
Comparative pharmacology and clinical efficacy of newer agents in treatment of heart failure.
Topics: Animals; Asthma; Carbamates; Cardiotonic Agents; Cardiovascular Agents; Clinical Trials as Topic; Dr | 1981 |
Management of systemic hypertension in children.
Topics: Adolescent; Antihypertensive Agents; Child; Clonidine; Diazoxide; Diet, Sodium-Restricted; Diuretics | 1982 |
Alpha 1-blockade in the management of hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Drug Therapy, Combination; Hu | 1993 |
Adrenergic mechanisms in left ventricular hypertrophy: significance and clinical implications.
Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Hemodynamics; Humans; H | 1993 |
Insulin resistance and hypertension in the elderly. Optimal drug therapy.
Topics: Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diuretics; Glucose; | 1994 |
Long-term efficacy and safety of terazosin.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hy | 1993 |
[Alpha-blocker].
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Antihypertensive Agents; Diagnosis, Different | 1995 |
[Terazosin].
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Male; Prazosin; Prostatic Hyperplasia | 1998 |
Treatment of benign prostatic hyperplasia and hypertension in elderly hypertensive patients.
Topics: Adrenergic alpha-Antagonists; Aged; Female; Humans; Hypertension; Male; Multicenter Studies as Topic | 1998 |
Alpha-blockers in hypertension: growing recognition as first line therapy.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Lipid Metabolism; Male; Prazosin; Prostatic Hype | 1998 |
Clinical pharmacology of antihypertensive drugs.
Topics: Adrenergic alpha-Antagonists; Aldosterone; Angiotensin II; Antihypertensive Agents; Bethanidine; Blo | 1977 |
Recent advances in the treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Drug Th | 1977 |
Antihypertensive drugs: clinical pharmacology and therapeutic use.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertens | 1977 |
[Etiology, pathogenesis and epidemiology of hypertension].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Animals; Benzothiadiazines; Cardiac Output; Cl | 1978 |
[New antihypertensive agents].
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertens | 1979 |
[Cardiac therapy in the old patient].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Body Water; Calcium; Clonidine; Digitalis Glycos | 1979 |
Prazosin: a review of its pharmacological properties and therapeutic efficacy in hypertension.
Topics: Animals; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Eruptions; Dru | 1977 |
[Prazocin (Peripress, Pfizer)].
Topics: Chemical Phenomena; Chemistry; Headache; Humans; Hypertension; Prazosin; Quinazolines; Tachycardia | 1977 |
Preventing, detecting and managing adverse reactions of antihypertensive agents in the ambulant patient with essential hypertension.
Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Drug Interactions; Ethacrynic Acid | 1977 |
Recent acquisitions in antihypertensive therapy: clonidine, minoxidil and prazosin.
Topics: Animals; Clonidine; Dogs; Hemodynamics; Humans; Hypertension; Minoxidil; Prazosin; Pyrimidines; Quin | 1978 |
Drug therapy. Prazosin.
Topics: Animals; Binding Sites; Dogs; Heart Failure; Humans; Hypertension; Prazosin; Quinazolines; Rats; Vas | 1979 |
Drug therapy of hypertension.
Topics: Angiotensin II; Antihypertensive Agents; Blood Pressure; Clonidine; Diuretics; Drug Evaluation; Huma | 1978 |
[Prazosin].
Topics: Administration, Oral; Humans; Hypertension; Prazosin; Protein Binding; Quinazolines | 1979 |
Acute and chronic therapy of hypertension with vasodilators.
Topics: Antihypertensive Agents; Diazoxide; Humans; Hypertension; Minoxidil; Nitroprusside; Prazosin; Time F | 1978 |
Doxazosin: a new alpha 1-adrenergic antagonist.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Antihypertensive Agents; Doxazosin; Hemodynamics | 1992 |
Terazosin: a new alpha adrenoceptor blocking drug.
Topics: Adrenergic alpha-Antagonists; Double-Blind Method; Drug Therapy, Combination; Hemodynamics; Humans; | 1992 |
The cardiovascular effects of alpha-receptor blocking agents.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cardiomegaly; Cardiovascular System; | 1992 |
Insulin resistance and hypertension.
Topics: Adipose Tissue; Animals; Captopril; Catecholamines; Disease Models, Animal; Fructose; Glucose Tolera | 1992 |
Alpha-blocker therapy of hypertension. An unfulfilled promise.
Topics: Adrenergic alpha-Antagonists; Doxazosin; Humans; Hypertension; Lipids; Prazosin | 1991 |
Terazosin: pharmacokinetics and the effect of age and dose on the incidence of adverse events.
Topics: Adrenergic alpha-Antagonists; Age Factors; Antihypertensive Agents; Dose-Response Relationship, Drug | 1991 |
Antihypertensive therapy: taking lipids into consideration.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; | 1991 |
Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; | 1991 |
The safety and efficacy of terazosin in the treatment of essential hypertension in blacks.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Black People; Double-Blind Metho | 1991 |
Effects of doxazosin on serum lipids: a review of the clinical data and molecular basis for altered lipid metabolism.
Topics: Antihypertensive Agents; Cholesterol; Clinical Trials as Topic; Coronary Disease; Doxazosin; Humans; | 1991 |
Efficacy of doxazosin in specific hypertensive patient groups.
Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Cardiomegaly; Diabetes Mellitus, Type 2; Doxazosin | 1991 |
Doxazosin therapy in the treatment of diabetic hypertension.
Topics: Antihypertensive Agents; Diabetes Mellitus, Type 2; Doxazosin; Humans; Hypertension; Lipids; Lipopro | 1991 |
New drugs for hypertension--variations on old themes.
Topics: Amlodipine; Antihypertensive Agents; Delayed-Action Preparations; Dihydropyridines; Doxazosin; Human | 1991 |
Efficacy and tolerance of doxazosin: a review.
Topics: Blood Pressure; Cholesterol; Double-Blind Method; Doxazosin; Forecasting; Humans; Hypertension; Lipo | 1990 |
Review of current therapeutic principles in hypertension.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diu | 1987 |
Comparison of pharmacokinetics and pharmacodynamics of adrenoceptor agonists and antagonists as antihypertensive agents.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Pressure; Clonidine; Doxazosin; Human | 1987 |
Factors influencing the lipid response to selective alpha 1-inhibition.
Topics: Adrenergic alpha-Antagonists; Animals; Cholesterol; Cholesterol, Dietary; Diet; Doxazosin; Humans; H | 1989 |
[New specialty drugs registered in Austria. Supressin].
Topics: Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Humans; Hypertens | 1989 |
Clinical pharmacotherapeutics of doxazosin.
Topics: Adrenergic alpha-Antagonists; Coronary Disease; Doxazosin; Hemodynamics; Humans; Hypertension; Prazo | 1989 |
Pharmacologic basis for the use of doxazosin in the treatment of essential hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Doxazosin; Hemodynamics; Humans; Hypertension; Muscle, Smooth | 1989 |
Selective alpha 1-adrenergic blockade, lipids, and coronary heart disease risk. Considerations in the treatment of mild hypertension.
Topics: Adrenergic alpha-Antagonists; Coronary Disease; Humans; Hypertension; Lipids; Prazosin; Risk Factors | 1989 |
Review of the effects of doxazosin, a new selective alpha 1-adrenergic inhibitor, on lipoproteins in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Doxazosin; Humans; Hydrochlorothiazide; H | 1989 |
Terazosin: a new antihypertensive agent with favorable effects on lipids.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Humans; Hypertension; Lipids; Prazos | 1989 |
Alpha-1 blockers. A new generation of antihypertensive agents.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Humans; Hypertension; Prazosin | 1989 |
The mechanism of the action of Minipress. Examinations in hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Clinical Trials as Topic; Drug Evaluation; Dr | 1989 |
Blood pressure and lipid lowering effects of terazosin.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Coronary Disease; Humans; Hyp | 1989 |
alpha 1-antagonists in the treatment of hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Doxazosin; Humans; Hypertensi | 1989 |
Minipress in hypertension.
Topics: Drug Therapy, Combination; Humans; Hypertension; Prazosin; Receptors, Adrenergic, alpha | 1986 |
Mono-aminergic receptors and blood pressure.
Topics: Adrenergic beta-Agonists; Blood Pressure; Catechol O-Methyltransferase; Cell Membrane; Clonidine; Do | 1985 |
[Effect of hypotensive agents on the lipid composition of the blood].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Cholesterol; Diureti | 1985 |
Alpha-adrenergic receptors and blood pressure control.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Drug Ev | 1986 |
Adverse effects of antihypertensive treatment.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Diuretics; Enzyme In | 1986 |
Treatment of hypertension in pregnancy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Eclampsia; Female; Human | 1986 |
Terazosin: a new alpha 1-blocker for the treatment of hypertension: a review of randomized, controlled clinical trials of once-daily administration as monotherapy.
Topics: Adrenergic alpha-Antagonists; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertension; P | 1986 |
Terazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Animals; Clinical Trials as Topic; Diuretics; Drug Therap | 1987 |
Terazosin: a new long-acting alpha 1-adrenergic antagonist for hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Heart Failure; Humans; Hypertension; Prazosin | 1988 |
Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Clinical Trials as Topic; Dogs; Doxa | 1988 |
Pharmacotherapeutic stature of doxazosin and its role in coronary risk reduction.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Coronary Disease; Dose-Response Relationship, | 1988 |
The usefulness of alpha-adrenoceptor blockade in the treatment of hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Humans; Hypertension; Indoramin; Labetalol; P | 1988 |
[Therapy of severe hypertension].
Topics: Acute Disease; Calcium Channel Blockers; Captopril; Enalapril; Humans; Hypertension; Minoxidil; Praz | 1987 |
Vasodilator drugs in the treatment of hypertension.
Topics: Calcium Channel Blockers; Captopril; Cardiac Output; Diazoxide; Diuretics; Dose-Response Relationshi | 1985 |
339 trials available for prazosin and Blood Pressure, High
| Article | Year |
|---|---|
A Randomized Crossover Pilot Study Examining the Effect of Carvedilol and Terazosin plus Enalapril on Urinary Symptoms of Patients with Hypertension and Benign Prostatic Hyperplasia.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Antihypertensive Agents; Carvedilol; Cross-Over Studi | 2021 |
Prospective study to compare peri-operative hemodynamic alterations following preparation for pheochromocytoma surgery by phenoxybenzamine or prazosin.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adult; Blood Pressure; Female; Heart Rate; He | 2014 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
Selective alpha adrenergic antagonist reduces severity of transient hypertension during sexual stimulation after spinal cord injury.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Ejaculation; Humans; Hypertension; Male; P | 2015 |
[Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring].
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibit | 2007 |
Efficacy of combined amlodipine/terazosin therapy in male hypertensive patients with lower urinary tract symptoms: a randomized, double-blind clinical trial.
Topics: Adrenergic alpha-Antagonists; Amlodipine; Antihypertensive Agents; Double-Blind Method; Drug Therapy | 2009 |
[Amlodipine combined with terazosin reduces postvoid residual and the risk of acute urinary retention].
Topics: Adrenergic alpha-Antagonists; Aged; Amlodipine; Antihypertensive Agents; Double-Blind Method; Drug T | 2009 |
[Management of hypertensive patients with left ventricular hypertrophy].
Topics: Adrenergic alpha-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent | 2002 |
[Effects of terazosine and atenolol on serum lipids in essential hypertension].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Ate | 2002 |
[Efficacy of and tolerance to prolonged release prazosin in patients with hypertension and non-insulin dependent diabetes].
Topics: Aged; Antihypertensive Agents; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Diabetic Angi | 2000 |
Adjunctive sympathoplegic therapy to ACE inhibition in Blacks with congestive heart failure: a comparison of alpha-1 with beta-1 blockade on exercise tolerance and cardiac sympathovagal reflex activity.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; | 2003 |
Effect of terazosin on blood pressure and serum lipids.
Topics: Antihypertensive Agents; Blood Pressure; Essential Hypertension; Humans; Hypercholesterolemia; Hyper | 1999 |
Influence of hypertension on lower urinary tract symptoms in benign prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Aged; Blood Pressure; Humans; Hypertension; Male; Prazosin; Prostatic | 2003 |
[Serum nitric oxide and D-dimer before and after administering antihypertensive drugs in essential hypertension].
Topics: Adrenergic alpha-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agent | 2003 |
High-dose terazosin therapy (5mg) in Korean patients with lower urinary tract symptoms with or without concomitant hypertension: a prospective, open-label study.
Topics: Adrenergic alpha-Antagonists; Aged; Asian People; Blood Pressure; Humans; Hypertension; Korea; Male; | 2007 |
Interaction of clonidine and beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Animals; Atenolol; Blood Pressure; Clinical Trials as Topic; Clo | 1980 |
Effect of propranolol and prazosin on blood lipids. The Oslo Study.
Topics: Cerebrovascular Disorders; Cholesterol; Coronary Disease; Drug Antagonism; Drug Therapy, Combination | 1980 |
Rest and exercise haemodynamic patterns with chronic prazosin or beta-blocker therapy in hypertensive cardiomegaly.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Cardiomegaly; Clinical Trials as Topic; Female; H | 1980 |
[Prazosin in the treatment of arterial hypertension. Results of multicenter studies].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug | 1981 |
[Comparison of the effects of prazosin and phenoxybenzamine on arterial pressure, heart rate and plasma catecolamines in essential arterial hypertension].
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1980 |
Hemodynamic and neuroendocrine responses to acute and chronic alpha-adrenergic blockade with prazosin and phenoxybenzamine.
Topics: Adrenergic alpha-Antagonists; Adult; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension | 1983 |
Within patient comparison of prazosin and UK-33,274. A new alpha-adrenoceptor-antagonist.
Topics: Adrenergic alpha-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Doxazosin; Female; Hea | 1982 |
A comparison of prazosin versus nadolol in combination with a diuretic.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Hu | 1984 |
Effects of alpha- and beta-blocker antihypertensive therapy on blood lipids: a multicenter trial.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; | 1984 |
Plasma lipid and lipoprotein changes in hypertensive patients treated with propranolol and prazosin.
Topics: Apoproteins; Blood Glucose; Blood Pressure; Cholesterol; Humans; Hypertension; Lipoproteins; Prazosi | 1982 |
Prazosin update. A review of its pharmacological properties and therapeutic use in hypertension and congestive heart failure.
Topics: Adrenergic alpha-Antagonists; Blood Pressure; Cardiovascular Diseases; Clinical Trials as Topic; Hea | 1983 |
Circulatory effects of noise.
Topics: Adult; Catecholamines; Female; Hemodynamics; Humans; Hypertension; Labetalol; Male; Middle Aged; Noi | 1983 |
Hydralazine and prazosin in the treatment of hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate | 1983 |
[Clinical aspects of prazosin therapy].
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Qu | 1983 |
Comparison of blood pressure, plasma lipid and cardiac performance responses to prazosin versus propranolol in thiazide-treated hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Diuretics; Dru | 1984 |
[Effect of the alpha 1-receptor blocker prazosin and the beta 1-receptor blocker acebutolol and their combination on blood pressure and pressure rate product. Ergometric studies of hypertensive patients].
Topics: Acebutolol; Adult; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Exercise Tes | 1984 |
Changes in serum lipid levels during antihypertensive therapy.
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Dose-Response Relationship, Dr | 1984 |
Comparative antihypertensive and endocrinologic effects of clonidine and prazosin in patients with essential hypertension.
Topics: Adult; Blood Pressure; Catecholamines; Chlorthalidone; Clinical Trials as Topic; Clonidine; Double-B | 1984 |
[Prazosin in 31 patients with primary arterial hypertension].
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Administration Schedule; Drug Thera | 1984 |
[Changes in vigilance after acute and repeated administration of the antihypertensive agents clonidine and prazosin].
Topics: Adult; Attention; Clonidine; Female; Humans; Hypertension; Long-Term Care; Male; Prazosin; Quinazoli | 1983 |
"Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Bendroflumethiazide; Blood Pressure; Cli | 1984 |
Our experience with minipress (prazosin) "Pfeiser" in the treatment of arterial hypertension.
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Humans; Hypertension; Middle Aged; Praz | 1983 |
Diuretic therapy for mild hypertension: the "real" cost of treatment.
Topics: Aged; Benzothiadiazines; Clinical Trials as Topic; Clonidine; Cost-Benefit Analysis; Diet; Diuretics | 1984 |
[Prazosin in arterial hypertension with cardiac insufficiency].
Topics: Adult; Aged; Cardiomegaly; Clinical Trials as Topic; Drug Therapy, Combination; Electrocardiography; | 1980 |
Combined pre- and after-load reduction in hypertensive patients with cardiomegaly and normal filling pressure.
Topics: Aged; Cardiomegaly; Hemodynamics; Humans; Hypertension; Middle Aged; Physical Exertion; Prazosin; Pr | 1981 |
On the combination of alpha- and beta-adrenoceptor blockade in hypertension.
Topics: Adult; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Ethanolamines; Female; Human | 1983 |
Long-term BP monitoring in the evaluation of antihypertensive therapy.
Topics: Adult; Aged; Blood Pressure; Circadian Rhythm; Drug Evaluation; Humans; Hypertension; Male; Middle A | 1983 |
Effects of prazosin and propranolol on serum lipids in patients with essential hypertension.
Topics: Blood Pressure; Cholesterol; Drug Therapy, Combination; Female; Humans; Hypertension; Lipoproteins; | 1984 |
[Methodologic approach to individual evaluation of the pharmacodynamic effects of single doses of hydralazine, endralazine, prazosine and propranolol in hypertension patients].
Topics: Adult; Antihypertensive Agents; Cardiac Output; Cardiography, Impedance; Humans; Hydralazine; Hypert | 1984 |
Double-blind comparison of dihydralazine and prazosin in hypertensive patients on the diuretic-reserpine regimen.
Topics: Adult; Aged; Clinical Trials as Topic; Dihydralazine; Double-Blind Method; Female; Humans; Hydralazi | 1981 |
Peripheral vasodilatation in the treatment of hypertension. Prazosin compared with hydralazine in patients not responding to beta-receptor blockade.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Drug Therapy, Combinati | 1982 |
[Peripress (Prazosin)-a new antihypertensive drug. Open trial in ambulatory patients with prazos in administered alone or in combination with beta-blocker].
Topics: Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hypertension; Prazosin; | 1980 |
[Cross-over trial with Peripress (prazosin) and Apresolin (hydralazin), both in combination with beta-blocker].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Cross-Sectional Studies; Drug Evaluation; Dru | 1980 |
A single blind crossover study of prazosin and methyldopa in hypertension.
Topics: Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Qui | 1980 |
Prazosin enhances the antihypertensive effects of beta-blockers during isometric and dynamic exercise.
Topics: Adult; Atenolol; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hypertension; | 1981 |
Measurement of the effects of a single dose of prazosin on the cerebral blood flow in hypertensive patients.
Topics: Adult; Cerebrovascular Circulation; Clinical Trials as Topic; Dose-Response Relationship, Drug; Doub | 1980 |
Comparative pharmacology and clinical efficacy of newer agents in treatment of heart failure.
Topics: Animals; Asthma; Carbamates; Cardiotonic Agents; Cardiovascular Agents; Clinical Trials as Topic; Dr | 1981 |
Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension.
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; O | 1981 |
Comparison of prazosin with hydralazine in patients receiving hydrochlorothiazide. A randomized, double-blind clinical trial.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blin | 1981 |
[Comparative study between prazosin and methyldopa in essential arterial hypertension: results of a parallel, randomized double-blind trial].
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamic | 1980 |
Prazosin and methyldopa in hypertension.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; | 1981 |
Prazosin depression of baroreflex function in hypertensive man.
Topics: Adult; Blood Pressure; Depression, Chemical; Heart; Heart Rate; Humans; Hypertension; Male; Middle A | 1982 |
[Changes in renal arterial flow during the treatment of essential arterial hypertension; prazosin in comparison with propranolol].
Topics: Adult; Blood Urea Nitrogen; Creatinine; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertensi | 1980 |
[Clinical experience with prazosin in Mexico].
Topics: Diuretics; Drug Evaluation; Drug Therapy, Combination; Humans; Hypertension; Polythiazide; Prazosin; | 1980 |
The antihypertensive effect of prazosin on mild to moderate hypertension, changes in plasma volume, extracellular volume and glomerular filtration rate.
Topics: Adult; Aged; Blood Pressure; Extracellular Space; Female; Glomerular Filtration Rate; Humans; Hypert | 1980 |
Double-blind cross-over comparison of hydralazine and prazosin in hypertensive subjects on a beta-adrenoceptor blocking agent (atenolol).
Topics: Atenolol; Double-Blind Method; Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Prazosi | 1980 |
Safety assessment of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia: a combined analysis.
Topics: Adrenergic alpha-Antagonists; Aged; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind M | 1994 |
Terazosin in the treatment of hypertension and symptomatic benign prostatic hyperplasia: a primary care trial.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Male; Middle Aged; Prazosin; Primary Health Care | 1994 |
Combined terazosin and verapamil therapy in essential hypertension. Hemodynamic and pharmacokinetic interactions.
Topics: Adult; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; H | 1995 |
Assessment of effects of two anti-hypertensive regimens on overall cardiovascular risk.
Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiovascular Diseases; Cholesterol; Diuretics; Drug Thera | 1995 |
Factors affecting lipoprotein lipase in hypertensive patients.
Topics: Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Insulin; Lipid | 1995 |
Vasodilators: scorpion envenoming and the heart (an Indian experience).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Bradycardia; Cardiovascular Diseases; Child; Ch | 1994 |
Long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensives: a multicenter prospective study.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Female; Glucose; Humans; Hypertension; Lipid Metabolism; | 1994 |
[Pressure and metabolic effects of terazosin in essential hypertension].
Topics: Adrenergic alpha-Antagonists; Adult; Atrial Natriuretic Factor; Blood Glucose; Double-Blind Method; | 1994 |
Renal haemodynamic effects of bunazosin retard and prazosin in mild to moderately hypertensive patients with normal or moderately impaired renal function.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Female; Glomerular Filtration | 1994 |
Comparison of the effects of terazosin and enalapril on laboratory stress testing blood pressure in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Double-Blind Method; Enalapril; Exercise Test; | 1993 |
Comparison of sublingual captopril, nifedipine and prazosin in hypertensive emergencies during hemodialysis.
Topics: Administration, Sublingual; Adult; Aged; Blood Pressure; Captopril; Chemistry, Pharmaceutical; Femal | 1993 |
Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Age Factors; Aged; Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Captopril; Cloni | 1993 |
[Evaluation of the efficacy and tolerance of three antihypertensive agents used as single-drug therapy, nifedipine, prazosin and acebutolol in severe, idiopathic hypertension in adolescents].
Topics: Acebutolol; Adolescent; Blood Glucose; Blood Pressure; Cholesterol, LDL; Clinical Protocols; Female; | 1993 |
Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive | 1996 |
Orthostatic hypotension: how to avoid it during antihypertensive therapy.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressur | 1996 |
Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension: comparison of six antihypertensive agents. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhib | 1997 |
Beneficial effect of alpha-blocker on hemorheology in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Viscosity; Erythrocyte Deformability; F | 1997 |
Salt enhances responsiveness of terminal aortic vascular bed to sympathetic activity.
Topics: Aged; Aorta; Arginine Vasopressin; Calcium Channel Blockers; Diet, Sodium-Restricted; Dihydropyridin | 1997 |
Effects of alpha 1-blockade on maximal vascular conductance in young borderline hypertensives.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Blood Pressure; Case-Control | 1997 |
The addition of a diuretic to anti-hypertensive therapy for early severe hypertension in pregnancy.
Topics: Adult; Amiloride; Antihypertensive Agents; Diuretics; Drug Combinations; Drug Therapy, Combination; | 1998 |
Effects of oral and intravenous terazosin and head-up tilt on blood pressure responses in patients with hypertension.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; | 1998 |
Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aging; Blood Pressure Monitoring, Ambulatory; | 1998 |
Terazosin in benign prostatic hyperplasia: effects on blood pressure in normotensive and hypertensive men.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressur | 1998 |
Vasodilator therapy of hypertensive acute left ventricular failure: comparison of captopril-prazosin with hydralazine-isosorbide dinitrate.
Topics: Adult; Antihypertensive Agents; Captopril; Drug Therapy, Combination; Female; Humans; Hydralazine; H | 1998 |
Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Captopri | 1999 |
Effects of terazosin therapy on blood pressure in men with benign prostatic hyperplasia concurrently treated with other antihypertensive medications.
Topics: Adrenergic alpha-Antagonists; Aged; Blood Pressure; Humans; Hypertension; Male; Prazosin; Prostatic | 1999 |
Alpha 2-agonist versus alpha 1-antagonist in mild-to-moderate hypertension: comparison of transdermal clonidine and terazosin monotherapies.
Topics: Administration, Cutaneous; Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adrenergic | 1997 |
Sympathoexcitatory responses to the acute blood pressure fall induced by central or peripheral antihypertensive drugs.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Double-Blind Method; Heart Rate; | 2000 |
Effects of a 3-month treatment with terazosin on fasting and postprandial glucose and lipid metabolism in type 2 diabetic patients with hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Area Under Curve; Blood Glucose; Choleste | 1999 |
Interaction of alcohol and an alpha1-blocker on ambulatory blood pressure in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure M | 2000 |
Nifedipine or prazosin as a second agent to control early severe hypertension in pregnancy: a randomised controlled trial.
Topics: Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hypertension; Ni | 2000 |
The relationship between terazosin dose and blood pressure response in hypertensive patients.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Pressure M | 2000 |
Effect of prazosin GITS, atenolol, nifedipine SR, and enalapril on ADP-induced platelet aggregation.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Angiotensin | 1998 |
Prazosin GITS vs sustained release nifedipine in patients with hypertension and abnormal lipid profile: a randomized, controlled, multicenter study. Madras Hypertension Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Delayed-Action Preparations; Female; Heart Rate; Humans; Hyper | 1998 |
Prazosin GITS vs atenolol in patients with hypertension and normal lipid profile: a randomized, controlled multicenter study. Hyderabad Hypertension Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Delayed-Action Preparations; Female; Heart; Humans; | 1998 |
A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group.
Topics: Adult; Aged; Antihypertensive Agents; Delayed-Action Preparations; Diabetes Complications; Enalapril | 1998 |
[The efficacy and safety of terazosin and tamsulosin in patients with urinary disturbance accompanying prostatic hypertrophy].
Topics: Adrenergic alpha-Antagonists; Aged; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Prazos | 2001 |
Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Clonidine; Diastole; Dilt | 2001 |
Prazosin-new hypertensive agent. A double-blind crossover study in the treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, C | 1977 |
Use of prazosin at the dunedin hypertension clinic controlled and open studies and pharmacokinetic observations.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; | 1977 |
Prazosin in hypertension. Clinical studies with special reference to initiation of therapy.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; | 1977 |
Indoramin and prazosin as adjuncts to beta adrenoceptor blockade in hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; D | 1979 |
Antihypertensive efficacy of a new long acting hydralazine like vasodilator, ISF 2469 in combination with a betablocker and a diuretic.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials a | 1979 |
The effects of alpha- and beta-adrenergic receptor blockers on the pressure responses to isometric exercise in hypertensive patients.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Blood Pressure; Humans; Hypertensi | 1979 |
Evaluation of beta blockade bendrofluazide, and prazosin in severe hypertension.
Topics: Adult; Aged; Atenolol; Bendroflumethiazide; Blood Pressure; Clinical Trials as Topic; Drug Evaluatio | 1977 |
Timing antihypertensive medication.
Topics: Blood Pressure; Circadian Rhythm; Drug Administration Schedule; Evaluation Studies as Topic; Humans; | 1979 |
Prazosin: a review of its pharmacological properties and therapeutic efficacy in hypertension.
Topics: Animals; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Eruptions; Dru | 1977 |
[Prazosin in the treatment of high blood pressure].
Topics: Adult; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Placebos; Prazosin | 1977 |
Studies with prazosin--a new effective hypotensive agent. II. Two double-blind cross-over studies comparing the effects of prazosin and hydrallazine.
Topics: Adult; Chlorothiazide; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fem | 1977 |
Prazosin in the therapy of uncontrolled hypertension.
Topics: Adult; Aged; Clinical Trials as Topic; Creatinine; Female; Humans; Hypertension; Hypotension, Orthos | 1977 |
Appraisal and reappraisal of cardiac therapy: prazosin.
Topics: Administration, Oral; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Hemodynamics; | 1978 |
Prazosin in hypertension. Part II. Effects of the initial dose.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Depression, Chemical; Double-Blind Method; Dr | 1977 |
Antihypertensive drug combinations: prazosin, hydrochlorothiazide and clonidine.
Topics: Blood Pressure Determination; Clinical Trials as Topic; Clonidine; Drug Combinations; Drug Evaluatio | 1977 |
Prazosin and clonidine for moderately severe hypertension.
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Clonidine; Drug Therapy, Comb | 1978 |
[Treatment of high blood pressure with prazosin (Peripress). An open study by 123 general physicians and 24 specialists in internal medicine].
Topics: Blood Pressure; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Hypertension; Male; Middl | 1978 |
Prazosin in hypertension with and without methyldopa.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydrochl | 1979 |
Comparative study with prazosin, methyldopa and polythiazide in arterial hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldop | 1979 |
Studies with prazosin--a new effective hypotensive agent. III. An acute double-blind cross-over study comparing the effects of single doses of prazosin and hydrallazine in combination with propranolol and a diuretic.
Topics: Adult; Aged; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Me | 1978 |
[Prazosine: a new vasodilator used for treatment of hypertension (author's transl)].
Topics: Acebutolol; Adult; Aged; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; Dru | 1978 |
[Blood pressure lowering effect of prazosin in severe hypertension].
Topics: Adult; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazol | 1979 |
Comparison of prazosin and methyldopa in mild to moderate hypertension, a multicenter cooperative study.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Mal | 1977 |
Antihypertensive action of drug combination: polythiazide, prazosin and tolamolol.
Topics: Adult; Drug Therapy, Combination; Humans; Hypertension; Hypokalemia; Male; Polythiazide; Potassium; | 1977 |
Antihypertensive effect of prazosin in combination with methyldopa, clonidine, or propranolol.
Topics: Adult; Blood Pressure; Clonidine; Drug Combinations; Drug Evaluation; Female; Heart Rate; Humans; Hy | 1979 |
A phase II study of prazosin hydrochloride in hypertensive subjects.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Aged; Pr | 1976 |
[Clinical trial of a new antihypertensive combination: prazosin and polythiazide].
Topics: Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Humans; Hypertension; Male; Mi | 1976 |
An open trial of prazosin in the treatment of hypertension.
Topics: Adolescent; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Mal | 1976 |
A cross-over study between hydrallazine and prazosin.
Topics: Clinical Trials as Topic; Humans; Hydralazine; Hypertension; Prazosin; Propranolol; Quinazolines | 1976 |
Prazosin: preliminary clinical and pharmacological observations.
Topics: Adult; Aged; Animals; Blood Pressure; Clinical Trials as Topic; Depression, Chemical; Drug Evaluatio | 1975 |
Prazosin in the treatment of hypertension.
Topics: Animals; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Double-Blind Method; Female; Hear | 1975 |
Antihypertensive effect of prazosin alone and its combination with polythiazide in patients with essential hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Drug Evaluation; Drug Therapy, Combination; Humans; | 1976 |
Influence of dosage and dietary sodium on the first-dose effects of prazosin.
Topics: Adult; Diet; Female; Humans; Hypertension; Hypotension, Orthostatic; Male; Middle Aged; Prazosin; Qu | 1977 |
Prazosin and hydrallazine in the treatment of hypertension.
Topics: Heart Rate; Humans; Hydralazine; Hypertension; Prazosin; Quinazolines; Time Factors | 1976 |
A comparison of the effects of the selective peripheral alpha 1-blocker terazosin with the selective beta 1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension.
Topics: Adult; Atenolol; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hy | 1992 |
Increase in serum total angiotensin-converting enzyme activity with enalapril therapy in humans: a controlled trial.
Topics: Double-Blind Method; Doxazosin; Drug Administration Schedule; Enalapril; Female; Humans; Hypertensio | 1992 |
Antihypertensive and metabolic effects of concomitant administration of terazosin and methyclothiazide for the treatment of essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Double-Blind Method; Drug Administration | 1992 |
Doxazosin: a new alpha 1-adrenergic antagonist.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Antihypertensive Agents; Doxazosin; Hemodynamics | 1992 |
Comparison of antihypertensive and lipid actions of terazosin and atenolol in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Dose-R | 1992 |
Double-blind placebo-controlled trial of terazosin effect on blood pressure and urinary output of dopamine in hypertensive patients.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Dopamine; Double-Blind Method; Female; Hu | 1992 |
Doxazosin in the management of hypertensive diabetes--a cautionary note (?).
Topics: Antihypertensive Agents; Diabetes Complications; Diabetes Mellitus; Doxazosin; Humans; Hypertension; | 1992 |
A double-blind comparative study of doxazosin and prazosin when administered with beta-blockers or diuretics.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Coronary Disease; Diuretics; Double-Blind Meth | 1991 |
The addition of doxazosin to the treatment regimen of patients with hypertension not adequately controlled by beta-blockers.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Doxazosin; Drug Therapy, Combination; Female; | 1991 |
A multicentre, hospital study of the efficacy and safety of terazosin and its effects on the plasma cholesterol levels of patients with untreated essential hypertension.
Topics: Adolescent; Adrenergic alpha-Antagonists; Blood Pressure; Cholesterol; Female; Hospitals; Humans; Hy | 1991 |
Antihypertensive dose-response relationships: studies with the selective alpha 1-blocking agent terazosin.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitors; Dose | 1991 |
Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Female; Follow-Up Studies; Humans; Hypertensi | 1991 |
Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; | 1991 |
The safety and efficacy of terazosin in the treatment of essential hypertension in blacks.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Black People; Double-Blind Metho | 1991 |
Cadralazine versus prazosin as second-step treatment in hypertensive patients on beta-blockers: a randomized multicentre study. The Italian Multicentre Study Group.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; | 1991 |
A multicentre, hospital study of the efficacy and safety of terazosin and its effects on the plasma cholesterol levels of patients with essential hypertension.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Cholesterol; Female; Human | 1991 |
[Comparative effects of doxazosin and enalapril in patients with arterial hypertension and exercise-induced acute myocardial ischemia].
Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Coronary Disease; Doxazosin; Enalapril; | 1991 |
Synergism between alpha 1-blockade and angiotensin converting enzyme inhibition in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Captopril; D | 1991 |
Vascular pressor responses in treated and untreated essential hypertension.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Antihypertensive Agents; Blood Pressure; Catecholamines; D | 1990 |
[The results of the comparative study of nadolol, propranolol, prazosin and hydrochlorothiazide in patients with arterial hypertension in a 12-month stepped-plan treatment (cooperative research). The Working Group of the Cooperative Program to Study New P
Topics: Adult; Blood Pressure; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Nadolol; Prazos | 1991 |
The results of the comparative study of nadolol, propranolol, prazosin and hydrochlorothiazide in patients with arterial hypertension in a 12-month stepped-plan treatment (cooperative research). The Working Group of the Cooperative Program to Study New Pr
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Male; M | 1991 |
[Hemodynamic response of patients with arterial hypertension to graded pedal isometric exercise after administration of vasodilators of different classes].
Topics: Adult; Aged; Antihypertensive Agents; Captopril; Drug Evaluation; Exercise Test; Female; Hemodynamic | 1991 |
Preliminary results of the Norwegian doxazosin postmarketing surveillance study: a twelve-week experience.
Topics: Antihypertensive Agents; Blood Pressure; Cholesterol; Coronary Disease; Doxazosin; Female; Heart Rat | 1991 |
Doxazosin: a study in a cohort of patients with hypertension in general practice--an interim report.
Topics: Antihypertensive Agents; Cholesterol; Cohort Studies; Coronary Disease; Doxazosin; England; Family P | 1991 |
An open, noncomparative study of doxazosin in essential hypertension: experience in general practice in The Netherlands.
Topics: Antihypertensive Agents; Cholesterol; Coronary Disease; Doxazosin; Family Practice; Female; Humans; | 1991 |
Doxazosin and atenolol as monotherapy in mild and moderate hypertension: a randomized, parallel study with a three-year follow-up.
Topics: Antihypertensive Agents; Atenolol; Cholesterol; Coronary Disease; Double-Blind Method; Doxazosin; Fe | 1991 |
Double-blind comparison of doxazosin and enalapril in patients with mild or moderate essential hypertension.
Topics: Antihypertensive Agents; Coronary Disease; Double-Blind Method; Doxazosin; Enalapril; Family Practic | 1991 |
A double-blind comparative study of doxazosin and prazosin in the treatment of essential hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Double-Blind Method; Doxazosin; Female; Heart Rate; Humans; | 1991 |
Clinical experience with doxazosin in general medical practice in New Zealand.
Topics: Antihypertensive Agents; Cholesterol; Coronary Disease; Doxazosin; Family Practice; Female; Humans; | 1991 |
Doxazosin in the treatment of essential hypertension in general medical practice in Latin America.
Topics: Antihypertensive Agents; Argentina; Cholesterol; Coronary Disease; Doxazosin; Family Practice; Femal | 1991 |
A multicenter study of doxazosin in the treatment of essential hypertension in France.
Topics: Antihypertensive Agents; Cholesterol; Coronary Disease; Doxazosin; Family Practice; Female; France; | 1991 |
Clinical experience with doxazosin in general medical practice in The Netherlands.
Topics: Antihypertensive Agents; Cholesterol; Coronary Disease; Doxazosin; Family Practice; Female; Humans; | 1991 |
A long-term study of doxazosin in the treatment of mild or moderate essential hypertension in general medical practice.
Topics: Antihypertensive Agents; Cholesterol; Doxazosin; Drug Therapy, Combination; Family Practice; Female; | 1991 |
Doxazosin in the treatment of mild or moderate essential hypertension: an echocardiographic study.
Topics: Adult; Antihypertensive Agents; Cardiomegaly; Doxazosin; Echocardiography; Female; Humans; Hypertens | 1991 |
Echocardiographic assessment of doxazosin on left ventricular mass in patients with essential hypertension.
Topics: Antihypertensive Agents; Cardiomegaly; Cholesterol; Coronary Disease; Doxazosin; Echocardiography; F | 1991 |
Efficacy and safety of doxazosin in the treatment of patients with mild or moderate essential hypertension and elevated levels of cholesterol.
Topics: Antihypertensive Agents; Cholesterol; Coronary Disease; Doxazosin; England; Female; Humans; Hyperten | 1991 |
A multicenter study of doxazosin in the treatment of patients with mild or moderate essential hypertension and concomitant intermittent claudication.
Topics: Antihypertensive Agents; Doxazosin; Female; Humans; Hypertension; Intermittent Claudication; Male; M | 1991 |
Evidence of an antiplatelet aggregation action of doxazosin in patients with hypertension: an ex vivo study.
Topics: Antihypertensive Agents; Cholesterol; Coronary Disease; Dose-Response Relationship, Drug; Doxazosin; | 1991 |
Effects of doxazosin on blood pressure, renin-angiotensin-aldosterone and urinary kallikrein.
Topics: Adult; Antihypertensive Agents; Double-Blind Method; Doxazosin; Drug Administration Schedule; Female | 1991 |
Doxazosin effects on insulin and glucose in hypertensive patients. The Finnish Multicenter Study Group.
Topics: Adult; Antihypertensive Agents; Blood Glucose; Doxazosin; Female; Finland; Humans; Hypertension; Ins | 1991 |
Acute effects of alpha- and beta-adrenoceptor blockade on plasma atrial natriuretic peptides during exercise in elderly patients with mild hypertension.
Topics: Aged; Atenolol; Atrial Natriuretic Factor; Carteolol; Exercise; Female; Humans; Hypertension; Male; | 1991 |
Effects of doxazosin and atenolol on the fibrinolytic system in patients with hypertension and elevated serum cholesterol.
Topics: Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Body Weight; Double-Blind Method; Doxazosi | 1991 |
Dose-response clarification in early drug development.
Topics: Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Doxazosin; Enalapril; Hum | 1991 |
[The effect of enalapril and prazosin on mild to moderate hypertension in black South Africans].
Topics: Adult; Aged; Black People; Double-Blind Method; Enalapril; Humans; Hypertension; Middle Aged; Prazos | 1991 |
Doxazosin in 'resistant' hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Diuretics; Doxazosin; Drug Therapy, Combination; Female; H | 1990 |
Alpha-blocker therapy; a possible advance in the treatment of diabetic hypertension--results of a cross-over study of doxazosin and atenolol monotherapy in hypertensive non-insulin dependent diabetic subjects.
Topics: Adrenergic alpha-Antagonists; Aged; Atenolol; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Doub | 1990 |
Acute effects of doxazosin and atenolol on smoking-induced peripheral vasoconstriction in hypertensive habitual smokers.
Topics: Adrenergic alpha-Antagonists; Adult; Atenolol; Double-Blind Method; Doxazosin; Female; Humans; Hyper | 1990 |
Blood pressure and heart rate response to repeated smoking before and after beta-blockade and selective alpha 1 inhibition.
Topics: Adrenergic alpha-Antagonists; Adult; Atenolol; Blood Pressure; Doxazosin; Heart Rate; Humans; Hypert | 1990 |
Long-term effects of doxazosin and atenolol on serum lipids and blood pressure in hypertensive smokers.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Atenolol; Double-Blind Method; Doxazosin; Fem | 1990 |
The effects of labetalol and prazosin on exercise haemodynamics in hypertensive patients.
Topics: Adult; Aged; Female; Headache; Hemodynamics; Humans; Hypertension; Labetalol; Male; Middle Aged; Phy | 1991 |
[Anti-hypertensive efficacy and tolerability of sustained-release prazosin hydrochloride. A Brazilian multicenter study].
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Drug Tolerance; Female; Humans; Hypertension; Ma | 1990 |
[Alpha-1 inhibition. Clinical studies of the efficacy and tolerability of Alpress LP in mild to moderate essential hypertension].
Topics: Antihypertensive Agents; Delayed-Action Preparations; Enalapril; Humans; Hypertension; Prazosin | 1990 |
[Alpha-1 inhibition. Prevention of coronary risk factors].
Topics: Atenolol; Coronary Disease; Delayed-Action Preparations; Female; Humans; Hypertension; Lipids; Male; | 1990 |
[Effect of long-term therapy with prazosin/propranolol on blood pressure and cardiopulmonary function in essential hypertension].
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Echocardiography; Electrocardiography; Exercise Te | 1990 |
Doxazosin in combination with atenolol in essential hypertension: a double-blind placebo-controlled multicentre trial.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Double-Blind Method; Dox | 1990 |
A long-term study of atenolol and doxazosin in mild and moderate hypertension.
Topics: Adolescent; Adult; Aged; Atenolol; Blood Pressure; Cholesterol; Double-Blind Method; Doxazosin; Fema | 1990 |
Efficacy and tolerance of doxazosin: a review.
Topics: Blood Pressure; Cholesterol; Double-Blind Method; Doxazosin; Forecasting; Humans; Hypertension; Lipo | 1990 |
An evaluation of the efficacy and safety of doxazosin in the treatment of hypertension associated with renal insufficiency.
Topics: Acute Kidney Injury; Adult; Blood Pressure; Doxazosin; Female; Heart Rate; Humans; Hypertension; Mal | 1990 |
Antihypertensive effect of doxazosin and atenolol in short- and long-term double-blind comparison.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Double-Blind Method; Doxazosin; Drug | 1990 |
[The antihypertensive response to prazosin, a selective vascular alpha blocker. A multicenter study].
Topics: Adult; Aged; Blood Pressure; Body Weight; Chi-Square Distribution; Chile; Female; Humans; Hypertensi | 1990 |
[Role of a beta adrenergic blocking agent nadolol (corgard) in prevention of arterial hypertension: a 6-month treatment (cooperative study)].
Topics: Adult; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Mult | 1990 |
Captopril in hypertensive black men in southern Africa.
Topics: Captopril; Drug Evaluation; Drug Therapy, Combination; Humans; Hypertension; Male; Methyldopa; Prazo | 1990 |
[Changes in lipid fractions of blood during the treatment of hypertension with prazosin and trasicor].
Topics: Adult; Antihypertensive Agents; Female; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; | 1990 |
Antihypertensive efficacy of guanfacine and prazosin in patients with mild to moderate essential hypertension.
Topics: Adult; Blood Pressure; Double-Blind Method; Drug Evaluation; Female; Guanfacine; Humans; Hypertensio | 1990 |
Effects of prazosin on platelet aggregation and plasma beta-thromboglobulin in essential hypertension.
Topics: Adult; Beta-Globulins; beta-Thromboglobulin; Blood Pressure; Clinical Trials as Topic; Female; Heart | 1985 |
Comparison of the effect of indoramin and prazosin on blood pressure and lipid profiles in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Human | 1986 |
Antihypertensive effects of indoramin and prazosin in combination with hydrochlorothiazide.
Topics: Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Heart Rate | 1986 |
Verapamil and prazosin in essential hypertension: evidence of a synergistic combination?
Topics: Adult; Biological Availability; Blood Pressure; Drug Synergism; Drug Therapy, Combination; Female; H | 1987 |
Felodipine compared to prazosin as additional therapy to a beta-blocking drug.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Felodipine; Female; Humans; Hy | 1987 |
Prazosin improves atherogenic index and inhibits the deleterious effect of dihydrochlorothiazide in patients with essential hypertension.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertens | 1987 |
Short-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Bli | 1988 |
Long-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Chemical Analysis; Blood Pressure; Double-Blin | 1989 |
Nifedipine-prazosin interaction in patients with essential hypertension.
Topics: Adult; Blood Pressure; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; He | 1989 |
Haemodynamic effect of prazosin during hyperosmolar mannitol load in essential hypertension.
Topics: Adolescent; Adult; Blood Pressure; Blood Volume; Cardiac Output; Female; Heart Rate; Humans; Hyperte | 1989 |
Comparison of doxazosin and atenolol in mild hypertension, and effects on exercise capacity, hemodynamics and left ventricular function.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Do | 1989 |
Effectiveness of doxazosin in systemic hypertension.
Topics: Adult; Antihypertensive Agents; Body Weight; Double-Blind Method; Doxazosin; Drug Administration Sch | 1989 |
[New specialty drugs registered in Austria. Supressin].
Topics: Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Humans; Hypertens | 1989 |
Concentration-effect relationships and individual responses to doxazosin in essential hypertension.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Doxazosin; Female; | 1989 |
Mild hypertension in the elderly. A comparison of prazosin and enalapril.
Topics: Aged; Blood Pressure; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Prazosin | 1989 |
Effects of alpha- and beta-adrenergic antagonists on plasma apolipoproteins and forearm blood flow in patients with mild hypertension.
Topics: Adult; Apolipoproteins; Clinical Trials as Topic; Double-Blind Method; Female; Forearm; Humans; Hydr | 1989 |
The effects of terazosin and methyclothiazide on blood pressure and serum lipids.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Apolipoproteins; Blood Pressure; Cholesterol; Clinical Tr | 1989 |
Alpha-1 adrenoceptor blockade with doxazosin in hypertension: effects on blood pressure and lipoproteins.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1989 |
The mechanism of the action of Minipress. Examinations in hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Clinical Trials as Topic; Drug Evaluation; Dr | 1989 |
alpha 1-antagonists in the treatment of hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Doxazosin; Humans; Hypertensi | 1989 |
[Alpress osmotic tablets: a major advance in the management of hypertensive patients].
Topics: Delayed-Action Preparations; Humans; Hypertension; Osmosis; Prazosin; Tablets | 1989 |
Initial antihypertensive drug therapy--a comparison of alpha-blocker (prazosin) and diuretic (hydrochlorothiazide). Brief summary of a randomized, controlled trial.
Topics: Blood Pressure; Clinical Trials as Topic; Female; Humans; Hydrochlorothiazide; Hypertension; Lipids; | 1989 |
Selective alpha-blockade versus angiotensin-converting enzyme inhibition as initial antihypertensive therapy. Effects on circulating lipoproteins.
Topics: Adult; Aged; Apolipoproteins; Captopril; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combinati | 1989 |
Effects of prazosin and labetalol on blood pressure control and blood lipid levels in patients with mild-to-moderate essential hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Labetalol; Lipi | 1989 |
Evaluation of the efficacy of prazosin versus propranolol as initial antihypertensive therapy.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Lip | 1989 |
Prazosin versus hydrochlorothiazide as initial antihypertensive therapy in black versus white patients.
Topics: Adult; Aged; Black People; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hydrochlorothia | 1989 |
The effect of chronic antihypertensive therapy on the index of left ventricular mass in patients with essential hypertension.
Topics: Adult; Antihypertensive Agents; Atenolol; Cardiac Volume; Clinical Trials as Topic; Echocardiography | 1989 |
[Effectiveness of the Russian drug prazosin in patients with arterial hypertension (Working Group for the Cooperative Study of New Drugs in the Prevention of Arterial Hypertension (CSDPAH)].
Topics: Adult; Clinical Trials as Topic; Humans; Hypertension; Male; Middle Aged; Multicenter Studies as Top | 1989 |
Efficacy and safety of Minipress XL, a new once-a-day formulation of prazosin.
Topics: Adult; Aged; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diuretics; Double-Blind Method; | 1989 |
[The role of minipress in hypertension].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Hemodynamics; Humans; Hypertension; M | 1989 |
[Minipress in the treatment of arterial hypertension in light of results from a multicenter study. I. 3-month treatment: monotherapy versus combination treatment].
Topics: Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypertension; | 1989 |
[Minipress in the treatment of arterial hypertension in light of results from a multicenter study. II. Results of long-term monotherapy].
Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Hypertension; Male; Middle Aged; Multicen | 1989 |
Felodipine in comparison with prazosin in hypertensive patients inadequately controlled on beta-blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Felodipine; Femal | 1985 |
Antihypertensive effectiveness of terazosin: a new long-acting alpha-adrenergic inhibitor.
Topics: Adrenergic alpha-Antagonists; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Humans; | 1985 |
Effects of alpha-adrenergic and beta-adrenergic receptor blockade on lipid metabolism.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Apolipoproteins | 1986 |
Initial antihypertensive drug therapy: alpha blocker or diuretic. Interim report of a randomized, controlled trial.
Topics: Adrenergic alpha-Antagonists; Adult; Cholesterol; Clinical Trials as Topic; Diuretics; Female; Human | 1986 |
Moderate essential hypertension control: a double-blind crossover study between a serotonin antagonist and a post-synaptic alpha-blocker.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hea | 1986 |
Clinical trials with terazosin. General methods.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Clinical Trials as Topic; Dose-Response Relat | 1986 |
Terazosin: an effective once-daily monotherapy for the treatment of hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Do | 1986 |
Effect of withdrawal of terazosin therapy in patients with hypertension.
Topics: Adrenergic alpha-Antagonists; Blood Pressure; Clinical Trials as Topic; Dizziness; Female; Follow-Up | 1986 |
Comparative trials of terazosin with other antihypertensive agents.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combina | 1986 |
Cumulative experience with terazosin administered in combination with diuretics.
Topics: Adrenergic alpha-Antagonists; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Meth | 1986 |
Experience with terazosin administered in combination with other antihypertensive agents.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; | 1986 |
Comparison of the safety and efficacy of once-daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Do | 1986 |
Efficacy of terazosin as an antihypertensive agent.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Age Factors; Aged; Antihypertensive Agents; Black o | 1986 |
Efficacy and safety of intravenous terazosin in hypertensive patients. A preliminary report.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; | 1986 |
Effects of oral antihypertensive agents on blood lipid levels.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Blood Pressure; Cl | 1986 |
Alpha-1-adrenergic blockade and lipoprotein metabolism in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combina | 1986 |
Terazosin: a new alpha 1-blocker for the treatment of hypertension: a review of randomized, controlled clinical trials of once-daily administration as monotherapy.
Topics: Adrenergic alpha-Antagonists; Clinical Trials as Topic; Double-Blind Method; Humans; Hypertension; P | 1986 |
Efficacy and safety of doxazosin in hypertension therapy.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Clinical Trials as Topic; Double-Blind M | 1987 |
A multicenter trial of doxazosin in West Germany.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Doxazo | 1987 |
Plasma lipid lowering effects of doxazosin, a new selective alpha1 adrenergic inhibitor for systemic hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Double-Blind Met | 1987 |
Serum lipid changes in a one-year, multicenter, double-blind comparison of doxazosin and atenolol for mild to moderate essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Clinical Trials as Top | 1987 |
An open one-year comparison of doxazosin and prazosin for mild to moderate essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Double | 1987 |
Multicenter, double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Clinical Trials as Top | 1987 |
Effects of alpha 1 inhibition on renal blood flow and sympathetic nervous activity in systemic hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Dopamine beta-Hydroxylase; Doxazosin; Female; | 1987 |
A double-blind parallel trial to assess the efficacy of doxazosin, atenolol and placebo in patients with mild to moderate systemic hypertension.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Atenolol; Clinical Trials as Topic; Double-Bl | 1987 |
Antihypertensive effects of doxazosin in systemic hypertension and comparison with terazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Double | 1987 |
Comparative effects of doxazosin and hydrochlorothiazide on serum lipids and blood pressure in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials | 1987 |
Terazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Animals; Clinical Trials as Topic; Diuretics; Drug Therap | 1987 |
Chronic effects of direct vasodilation (pinacidil), alpha-adrenergic blockade (prazosin) and angiotensin-converting enzyme inhibition (captopril) in systemic hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensiv | 1987 |
Terazosin for hypertension.
Topics: Adrenergic alpha-Antagonists; Clinical Trials as Topic; Humans; Hypertension; Prazosin | 1987 |
Effect of prazosin and beta-blocker monotherapy on serum lipids: a cross-over, placebo-controlled study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Ra | 1987 |
Felodipine versus prazosin as an addition to a beta-blocker in the treatment of essential hypertension. The Australian Multicentre Study.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials a | 1987 |
Hormonal and blood pressure responses to tilting in beta-blocked essential hypertension treated with felodipine or prazosin.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; C | 1987 |
Doxazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in mild or moderate hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Clinical Trials as Topic; Dogs; Doxa | 1988 |
Terazosin, a new selective alpha 1-adrenergic blocking agent. Results of long-term treatment in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Body Weight; Female; Humans; Hypertension | 1988 |
A multicenter study of doxazosin in the treatment of severe essential hypertension.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Doxa | 1988 |
Doxazosin: a newly developed, selective alpha 1-inhibitor in the management of patients with pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Catecho | 1988 |
Comparison of the effects of doxazosin and atenolol on blood pressure and blood lipids: a one-year, double-blind study in 228 hypertensive patients.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Coronary D | 1988 |
A comparative study of doxazosin versus atenolol in mild-to-moderate hypertension.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Doxazosin; | 1988 |
A double-blind comparative study of doxazosin and nitrendipine in patients with mild-to-moderate essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
A comparison of doxazosin and enalapril in the treatment of mild and moderate essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Doxazosin; Enala | 1988 |
Terazosin in mild hypertension: experience in open trials.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; M | 1987 |
Terazosin (Hytrin): cumulative experience of clinical trials in the USA for the treatment of mild to moderate essential hypertension.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Clinical Trials as Topic; Female; Humans; Hyp | 1987 |
Alpha-adrenoceptors and the kidney.
Topics: Adrenergic alpha-Antagonists; Doxazosin; Humans; Hypertension; Kidney; Prazosin; Receptors, Adrenerg | 1988 |
Effect of atenolol or prazosin on maximal exercise performance in hypertensive joggers.
Topics: Adult; Aged; Atenolol; Blood Pressure; Cardiac Output; Exercise Test; Heart Rate; Humans; Hypertensi | 1989 |
Comparative effects of prazosin and hydrochlorothiazide on sexual function in hypertensive men.
Topics: Blood Pressure; Humans; Hydrochlorothiazide; Hypertension; Male; Penile Erection; Prazosin; Sleep, R | 1989 |
Effect of alpha- and selective beta-blockade for hypertension control on plasma lipoproteins, apoproteins, lipoprotein subclasses, and postprandial lipemia.
Topics: Apoproteins; Atenolol; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Eating; Huma | 1989 |
Comparative effects of prazosin and propranolol on blood lipid profiles in hypertensive, hypercholesterolemic patients. Preliminary results.
Topics: Adult; Aged; Apoproteins; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholester | 1989 |
Forearm and finger hemodynamics, blood pressure control, and lipid changes in diabetic hypertensive patients treated with atenolol and prazosin. A brief report.
Topics: Adult; Aged; Atenolol; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Female; Fingers; F | 1989 |
Assessment of the effects of alpha- and beta-blockade in hypertensive patients who smoke cigarettes.
Topics: Adult; Aged; Blood Pressure; Humans; Hypertension; Lipoproteins; Middle Aged; Prazosin; Propranolol; | 1989 |
The long-term antihypertensive effects of prazosin and atenolol.
Topics: Atenolol; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertensi | 1989 |
Prazosin in hypertensive patients with chronic bronchitis and asthma: a brief report.
Topics: Asthma; Blood Pressure; Bronchitis; Chronic Disease; Forced Expiratory Volume; Humans; Hypertension; | 1989 |
Effects of antihypertensive therapy on blood pressure control, cognition, and reactivity. A placebo-controlled comparison of prazosin, propranolol, and hydrochlorothiazide.
Topics: Antihypertensive Agents; Blood Pressure; Cognition; Heart Rate; Humans; Hydrochlorothiazide; Hyperte | 1989 |
A long-term double-blind comparison of doxazosin and atenolol in patients with mild to moderate essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Bli | 1986 |
Antihypertensive effect of doxazosin in hypertensive patients: comparison with atenolol.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Bli | 1986 |
Multicentre 12-week double-blind comparison of doxazosin, prazosin and placebo in patients with mild to moderate essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Body Weight; Clinical Trials as Topic; Double-Blind Method; Do | 1986 |
Double-blind comparison of the effects of long-term treatment with doxazosin or atenolol on serum lipoproteins.
Topics: Adult; Aged; Antihypertensive Agents; Apolipoproteins; Atenolol; Cholesterol; Cholesterol, HDL; Clin | 1986 |
The antihypertensive effects of doxazosin: a clinical overview.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Cholesterol; Cholesterol | 1986 |
Ketanserin and prazosin: a comparison of antihypertensive and biochemical effects.
Topics: Adult; Aldosterone; Blood Pressure; Cholesterol; Drug Evaluation; Female; Heart Rate; Humans; Hypert | 1986 |
Treatment of essential hypertension with PN 200-110 (isradipine).
Topics: Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Double-Blind Method; Drug Therap | 1987 |
Clinical pharmacology of doxazosin in patients with essential hypertension.
Topics: Adult; Blood Pressure; Blood Proteins; Doxazosin; Female; Half-Life; Heart Rate; Humans; Hypertensio | 1987 |
The pharmacokinetics and pharmacodynamics of doxazosin compared with atenolol during long-term double-blind treatment.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Bli | 1987 |
Vasodilators and regression of left ventricular hypertrophy. Hydralazine versus prazosin in hypertensive humans.
Topics: Adult; Cardiomegaly; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; Prazosin; Vasodil | 1987 |
A 24-week multicenter double-blind study of doxazosin and hydrochlorothiazide in patients with mild to moderate essential hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Heart | 1987 |
[Doxazosin and nitrendipine. A double-blind comparative study in patients with mild to moderate hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Fema | 1987 |
A double-blind and cross-over comparison of once daily doxazosin and placebo with steady-state pharmacokinetics in elderly hypertensive patients.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Doxazo | 1988 |
Effect of doxazosin monotherapy on blood pressure and plasma lipids in patients with essential hypertension.
Topics: Blood Pressure; Doxazosin; Female; Heart Rate; Humans; Hypertension; Lipids; Male; Middle Aged; Nore | 1988 |
24-hour control of blood pressure by once daily doxazosin: a multicentre double-blind comparison with placebo.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Doxazosin; Female; Human | 1988 |
Doxazosin in patients with hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Doxazosin; Female; Half-Life; Heart Rate; Humans; Hy | 1988 |
Double-blind comparison of urapidil and prazosin in the treatment of patients with essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, C | 1988 |
Initial antihypertensive drug therapy. Final report of a randomized, controlled trial comparing alpha-blocker and diuretic.
Topics: Adult; Aged; Blood Pressure; Cholesterol; Clinical Trials as Topic; Drug Therapy, Combination; Femal | 1988 |
Comparative trial of pinacidil versus prazosin in mild to moderate arterial hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Electrocardiography; Femal | 1988 |
Double-blind comparator trials with pinacidil, a potassium channel opener.
Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Guanidines; | 1988 |
Effects of prazosin and propranolol on blood lipids and lipoproteins in hypertensive patients.
Topics: Adult; Aged; Apolipoprotein A-I; Apolipoproteins A; Blood Pressure; Cholesterol; Cholesterol, LDL; C | 1986 |
Effect of prazosin and propranolol on lipoproteins of hypertensive patients.
Topics: Adult; Aged; Apolipoprotein A-I; Apolipoproteins A; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; | 1987 |
The antihypertensive effect of pinacidil versus prazosin in mild to moderate hypertensive patients seen in general practice.
Topics: Antihypertensive Agents; Blood Pressure; Electrocardiography; Family Practice; Female; Guanidines; H | 1988 |
Concomitant administration of terazosin and atenolol for the treatment of essential hypertension.
Topics: Adult; Aged; Atenolol; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; | 1988 |
Exercise stress test in young hypertensive patients. Response to vasodilators (prazosin) vs. beta-blocker (atenolol) agents.
Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Hemod | 1988 |
Comparison of labetalol and prazosin in hypertensive patients using automated ambulatory monitoring.
Topics: Activities of Daily Living; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; H | 1988 |
The combination of prazosin and verapamil in the treatment of essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Catecholamines; Drug Therapy, Combination; Female; Heart Rate; H | 1988 |
Are effects of antihypertensive treatment on lipoproteins merely "side-effects"? A comparison of prazosin and metoprolol.
Topics: Clinical Trials as Topic; Female; Humans; Hypertension; Lipids; Lipoproteins; Male; Metoprolol; Midd | 1988 |
Vasodilator monotherapy in the treatment of hypertension: comparative efficacy and safety of pinacidil, a potassium channel opener, and prazosin.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Data Interpretation, Statistical; Double-Blin | 1988 |
Forearm and finger hemodynamics, blood pressure control, and lipid changes in patients with diabetic hypertension treated with atenolol and prazosin.
Topics: Adult; Aged; Atenolol; Blood Pressure; Clinical Trials as Topic; Diabetes Complications; Female; Fin | 1988 |
Acute and chronic ketanserin in essential hypertension: antihypertensive mechanisms and pharmacokinetics.
Topics: Adult; Aldosterone; Angiotensin II; Blood Pressure; Electrocardiography; Female; Heart Rate; Humans; | 1987 |
Comparative effects of pinacidil and prazosin on blood pressure, weight, plasma volume, the renin-angiotensin-aldosterone system, and the renal kallikrein-kinin system in patients with essential hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as To | 1987 |
Blood pressure monitoring for assessing the duration of action of antihypertensive treatment.
Topics: Adult; Aged; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Random Alloc | 1987 |
The effects of prazosin and propranolol in combination with thiazide diuretics on blood pressure and serum lipids: a multicentre study.
Topics: Benzothiadiazines; Blood Pressure; Diuretics; Drug Therapy, Combination; Heart Rate; Humans; Hyperte | 1987 |
Metabolic effects of a change in antihypertensive treatment.
Topics: Animals; Atenolol; Blood Glucose; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Female; G | 1986 |
Effects of two antihypertensive agents on lipids, lipoproteins, and apoproteins A and B. Comparison of prazosin and atenolol.
Topics: Adult; Aged; Apolipoproteins A; Apolipoproteins B; Atenolol; Blood Pressure; Cholesterol, HDL; Chole | 1986 |
Initial antihypertensive therapy. Comparison of prazosin and hydrochlorothiazide.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Fem | 1986 |
Comparison of the effects of prazosin versus propranolol on plasma lipoprotein lipids in patients receiving hemodialysis.
Topics: Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Female; H | 1986 |
Effects of prazosin, atenolol, and thiazide diuretic on plasma lipids in patients with essential hypertension.
Topics: Atenolol; Benzothiadiazines; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Top | 1986 |
An evaluation of self-recorded blood pressure during drug trials.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Determination; Clinical Trials as Topic; Evaluation Stud | 1986 |
[Use of prazosin in patients with hypertension].
Topics: Adult; Aged; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; | 1986 |
[Analysis of hypotensive and hemodynamic effects of prazosin in patients with hypertension].
Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Drug Therapy, Combination; Fe | 1986 |
Effect of trial therapy on subsequent therapy. A review of patients with hypertension who have completed a pharmacological intervention study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Family Practice; Humans; H | 1986 |
Changes in ventricular septal thickness in systemic hypertension during treatment with methyldopa and prazosin.
Topics: Adult; Clinical Trials as Topic; Echocardiography; Heart Septum; Heart Ventricles; Humans; Hypertens | 1986 |
Prazosin versus captopril as initial therapy. Effect on hypertension and lipid levels.
Topics: Adult; Aged; Captopril; Drug Therapy, Combination; Humans; Hypertension; Lipids; Middle Aged; Polyth | 1987 |
[Endralazine monotherapy in comparison with prazosin and hydralazine in arterial hypertension].
Topics: Adult; Clinical Trials as Topic; Humans; Hydralazine; Hypertension; Male; Middle Aged; Prazosin; Pyr | 1986 |
[Prazosin in the initial treatment of arterial hypertension].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Lip | 1986 |
Comparison of nifedipine, prazosin and hydralazine added to treatment of hypertensive patients uncontrolled by thiazide diuretic plus beta-blocker.
Topics: Adult; Aged; Atenolol; Bendroflumethiazide; Blood Pressure; Drug Administration Schedule; Drug Thera | 1987 |
[Clinical effect of pratsiol in arterial hypertension].
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Middle Ag | 1985 |
[Comparative study of the effects of prazosin and atenolol on plasma lipids of hypertensive patients].
Topics: Atenolol; Clinical Trials as Topic; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Prazosi | 1985 |
Working ability and exercise tolerance during treatment of mild hypertension. II. A comparison between atenolol and prazosin medication.
Topics: Adult; Atenolol; Blood Pressure; Clinical Trials as Topic; Disability Evaluation; Double-Blind Metho | 1985 |
A comparison of labetalol and prazosin combined with atenolol in non-responders to atenolol plus hydrochlorothiazide in uncomplicated hypertension.
Topics: Adult; Atenolol; Chlorothiazide; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans | 1985 |
Effects of prazosin and alphamethyldopa on blood lipids and lipoproteins in hypertensive patients.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Fatty Acids, Nonesterified; Heart Rate; Humans; Hyp | 1985 |
[Comparative, open and randomized evaluation of the antihypertensive activity of nifedipine and prazosin hydrochloride].
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Heart Rat | 1985 |
Haemodynamic effects of prazosin combinations during dynamic and isometric exercise.
Topics: Adult; Atenolol; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Electrocardiography | 1985 |
Quadruple therapy for resistant hypertension.
Topics: Antihypertensive Agents; Drug Therapy, Combination; Female; Guanethidine; Humans; Hypertension; Male | 1985 |
Prazosin once or twice daily?
Topics: Adult; Aged; Amiloride; Atenolol; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; | 1985 |
[Change in the spectrum of lipids and apoproteins A1 and B as affected by hypothiazide and pratsiol in patients with hypertension].
Topics: Adult; Apolipoproteins A; Apolipoproteins B; Cholesterol, HDL; Cholesterol, LDL; Humans; Hydrochloro | 1985 |
677 other studies available for prazosin and Blood Pressure, High
| Article | Year |
|---|---|
Thiophene systems. 9. Thienopyrimidinedione derivatives as potential antihypertensive agents.
Topics: Animals; Blood Pressure; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Hypertensi | 1988 |
6,7-Dihydro-5-[[(cis-2-hydroxy-trans-3-phenoxycyclopentyl)amino] methyl]-2-methylbenzo[b]thiophen-4(5H)-one: a novel alpha 1-adrenergic receptor antagonist and renal vasodilator.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Dogs; Hypertension; Male; Natr | 1985 |
2,4-diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Brain; Dioxanes; Dio | 1987 |
Synthesis, in vitro [3H]prazosin displacement, and in vivo activity of 3-aryl-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines, a new class of antihypertensive agents.
Topics: Animals; Brain; Cats; Chemical Phenomena; Chemistry; Dogs; Hypertension; Hypertension, Renovascular; | 1985 |
Antihypertensive thiadiazoles. 1. Synthesis of some 2-aryl-5-hydrazino-1,3,4-thiadiazoles with vasodilator activity.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Decerebrate State; Hydrazines; Hypertension; Male; | 1988 |
Synthesis and antihypertensive activity of some new quinazoline derivatives.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Drug Evaluation, Preclinical; Hypertension; Male; | 1983 |
The sympathetic nervous system exacerbates carotid body sensitivity in hypertension.
Topics: Animals; Blood Pressure; Carotid Body; Hypertension; Phenylephrine; Prazosin; Rats; Rats, Inbred SHR | 2023 |
Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats.
Topics: Animals; Hepcidins; Hypertension; Iron; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2022 |
Evaluation of syncope association with α
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Doxazosin; Humans; Hypertension; Indoles; Male; Midd | 2019 |
Micturition syncope secondary to urinary bladder paraganglioma.
Topics: 3-Iodobenzylguanidine; Adrenergic alpha-1 Receptor Antagonists; Adult; Diagnosis, Differential; Diag | 2020 |
Ruptured functioning adrenal tumour, atypical presentation with renal colic and hypertension.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adult; Computed Tomography Angiography; Diagnosis, Differen | 2020 |
Acute hypertensive crisis due to newly diagnosed pheochromocytoma in the ninth decade of life: an unusual presentation.
Topics: Adrenal Gland Neoplasms; Aged, 80 and over; Antihypertensive Agents; Humans; Hypertension; Male; Phe | 2021 |
Transdermal iontophoresis delivery system for terazosin hydrochloride: an
Topics: Administration, Cutaneous; Adrenergic alpha-1 Receptor Antagonists; Animals; Antihypertensive Agents | 2021 |
Alopecia areata: A rare side effect of prazosin.
Topics: Alopecia Areata; Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions; Humans; H | 2021 |
Dwarfism and insulin resistance in male offspring caused by α1-adrenergic antagonism during pregnancy.
Topics: Adipose Tissue, Brown; Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Newborn; Dwarfism; | 2017 |
Is Pretreatment Blood Pressure a Marker of Prazosin Response in Posttraumatic Stress Disorder With Comorbid Alcohol Use Disorder?
Topics: Alcoholism; Blood Pressure; Comorbidity; Endophenotypes; Humans; Hypertension; Prazosin; Randomized | 2019 |
Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; | 2019 |
Drug utilization and blood pressure control in a population where antihypertensives are given free: effect of policy change.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti | 2012 |
Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Carotid Arteries; Heart; Hypertensi | 2013 |
Intravital Förster resonance energy transfer imaging reveals elevated [Ca2+]i and enhanced sympathetic tone in femoral arteries of angiotensin II-infused hypertensive biosensor mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biosensing Techniques; Calcium; Calcium Signaling; | 2013 |
Selective alpha(1)-adrenoceptor blockade prevents fructose-induced hypertension.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Fructose; Hypertension; Insul | 2014 |
Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Amlodipine; Animals; Atropine; Enalapril; | 2014 |
Effects of hippadine on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats.
Topics: Amaryllidaceae Alkaloids; Animals; Antihypertensive Agents; Atenolol; Blood Pressure; Crinum; Dose-R | 2014 |
Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report.
Topics: Antihypertensive Agents; Biotransformation; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytoch | 2015 |
Sympathetic Hyperactivity, Sleep Fragmentation, and Wake-Related Blood Pressure Surge During Late-Light Sleep in Spontaneously Hypertensive Rats.
Topics: Activity Cycles; Adrenergic alpha-1 Receptor Antagonists; Animals; Antihypertensive Agents; Barorefl | 2016 |
Pheochromocytoma multisystem crisis with transient stress cardiomyopathy due to ruptured pheochromocytoma.
Topics: Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Antihypertensive Agents; Breast Neop | 2015 |
Laparoscopic Surgery for Pheochromocytoma and Paraganglioma Removal: A Retrospective Analysis of Anaesthetic Management.
Topics: Adrenal Gland Neoplasms; Anesthesia; Anesthetics; Antihypertensive Agents; Humans; Hypertension; Int | 2016 |
Protective effects of MCR-1329, a dual α1 and angII receptor antagonist, in mineralocorticoid-induced hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; | 2016 |
Differential effects of prazosin and naftopidil on pelvic blood flow and nitric oxide synthase levels in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Hypertension; Male; Naphthalenes; Nitric Oxide Synthase; Pelv | 2008 |
Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Age Factors; Angiotensin II; | 2008 |
The effects of autoantibodies against the second extracellular loop of alpha(1)-adrenoceptor on vasoconstriction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Aged; Animals; Autoantibodies | 2009 |
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood Pressure; Hypertension; Leptin; Male; Mice; Mice | 2009 |
Pheochromocytoma in children and adolescents.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenergic alpha-Antagonists; Child; Doxazosin; | 2009 |
Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control.
Topics: Animals; Baroreflex; Blood Pressure Determination; Disease Models, Animal; Humans; Hypertension; Mic | 2010 |
Role of sympathetic tone in BSO-induced hypertension in mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Blood Pressure; Buthionine Sulfoximine; Ganglionic | 2010 |
Hemodynamic responses to aortic depressor nerve stimulation in conscious L-NAME-induced hypertensive rats.
Topics: Angiotensin II; Animals; Aorta; Atenolol; Atropine Derivatives; Baroreflex; Blood Pressure; Electric | 2011 |
Role of alpha adrenoceptors and nitric oxide on cardiovascular responses in acute and chronic hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2011 |
Long-term effect of prazosin administration on blood pressure, heart and structure of coronary artery of young spontaneously hypertensive rats.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Animals; Blood Pressure; Blood Pressure Dete | 2011 |
Multiple cerebral infarctions related to famotidine-induced eosinophilia.
Topics: Acarbose; Adrenergic alpha-1 Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulc | 2012 |
[Antihypertensive therapy and thyroid function: effect of prazosin and its combination with beta-blockers].
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Drug Therapy, Combination; Humans; Hype | 2002 |
Nitric oxide opposes glucose-induced hypertension by suppressing sympathetic activity.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Enzyme Inhibitor | 2003 |
[Hepatotoxicity induced by terazosin].
Topics: Adrenergic alpha-Antagonists; Chemical and Drug Induced Liver Injury; Humans; Hypertension; Liver; L | 2003 |
The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.
Topics: 4-Aminopyridine; Adrenalectomy; Adrenergic Antagonists; Amifampridine; Angiotensin Receptor Antagoni | 2003 |
For the patient. New treatments for heart failure in Black people. Adjunctive sympathoplegic therapy to ACE inhibition in Blacks with congestive heart failure: a comparison of alpha-1 with beta-1 blockade on exercise tolerance and cardiac sympathovagal re
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; | 2003 |
ROS during the acute phase of Ang II hypertension participates in cardiovascular MAPK activation but not vasoconstriction.
Topics: Acute Disease; Adrenergic alpha-Agonists; Angiotensin II; Animals; Antioxidants; Aorta; Benzimidazol | 2004 |
Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Bisoprolol; Blood Pressure; Calc | 2004 |
Hypertension and insulin resistance are not directly related in obese dogs.
Topics: Adrenergic beta-Antagonists; Animals; Aspirin; Atenolol; Blood Glucose; Clonidine; Diet, Sodium-Rest | 2004 |
RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Cells, Cultured; Cyclic AMP; Cyclic GMP; Hy | 2004 |
Sponsorship of educational programmes in Nigerian medical and pharmacy schools by pharmaceutical companies: possible risk implication for public health.
Topics: Advertising; Conflict of Interest; Drug Industry; Education, Medical; Education, Pharmacy; Financial | 2001 |
Sympathetic and angiotensin-dependent hypertension during cage-switch stress in mice.
Topics: Angiotensins; Animals; Atenolol; Blood Pressure; Heart Rate; Housing, Animal; Hypertension; Male; Mi | 2004 |
Neurohumoral mechanisms involved in the hypertensive response elicited by bilateral carotid occlusion in conscious intact or chronically sympathectomized rats.
Topics: Adrenal Glands; Adrenergic alpha-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Bloo | 2004 |
Cardiac remodeling after long-term stimulation by antibodies against the alpha1-adrenergic receptor in rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; An | 2005 |
Experimental orthostasis elicits sustained hypertension, which can be prevented by sympathetic blockade in the rat.
Topics: Animals; Blood Pressure; Chloralose; Dizziness; Heart Rate; Hypertension; Male; Prazosin; Rats; Rats | 2005 |
Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Consciousness; Dose-Respons | 2005 |
Inverse-orthostasis may induce elevation of blood pressure due to sympathetic activation.
Topics: Anesthetics, Intravenous; Animals; Antihypertensive Agents; Blood Pressure; Chloralose; Head-Down Ti | 2006 |
Does bradycardia or hypertension enhance gas transfer in rainbow trout (Oncorhynchus mykiss)?
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Bradycardia; Branchial Region; Carb | 2006 |
Nocturnal hypertension in mice consuming a high fructose diet.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Glucose; Body Weight; Brain Stem; Circa | 2006 |
Paraventricular-coerulear interactions: role in hypertension induced by prenatal undernutrition in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Corticotropin-Releasing Hormone; Diet | 2006 |
Genetic and dietary interactions: role of angiotensin AT1a receptors in response to a high-fructose diet.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Bloo | 2007 |
Coerulear activation by crh and its role in hypertension induced by prenatal malnutrition in the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Corticosterone; Corticotropin-Releasi | 2007 |
The effects of salt-induced hypertension on alpha1-adrenoreceptor expression and cardiovascular physiology in the rainbow trout (Oncorhynchus mykiss).
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Blood Pressure; Cardiovascular Physiological Phenom | 2007 |
Effect of peripheral sympathetic nerve dysfunction on salt sensitivity of arterial pressure.
Topics: Animals; Antihypertensive Agents; Autonomic Nervous System Diseases; Blood Pressure; Dose-Response R | 2008 |
Delayed effects of hypotensive drugs on structural characteristics of the renal glomerular system in hypertensive NISAG rats.
Topics: Animals; Antihypertensive Agents; Enalapril; Hypertension; Kidney Glomerulus; Losartan; Male; Nifedi | 2007 |
Cerebral and renal alpha-adrenoceptors in Sabra hypertensive (SBH) and normotensive (SBN) rats: effects of high-sodium diet.
Topics: Animals; Brain; Hypertension; Kidney; Kidney Cortex; Kinetics; Male; Membranes; Prazosin; Rats; Rece | 1984 |
Sympathetic nervous system in essential hypertension and antihypertensive response to alpha 2-adrenoceptor stimulation.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Clonidine; Humans; Hypertension; Norepinephrine; | 1984 |
Adrenaline induces vasoconstriction through post-junctional alpha 2 adrenoceptors and this response is enhanced in patients with essential hypertension.
Topics: Adult; Epinephrine; Female; Forearm; Humans; Hypertension; Male; Middle Aged; Nitroprusside; Prazosi | 1984 |
Dietary sodium regulation of alpha 2-adrenoceptors in Sabra hypertensive (SHB) and normotensive (SBN) rats.
Topics: Animals; Cerebral Cortex; Hypertension; Kidney Cortex; Male; Prazosin; Radioligand Assay; Rats; Rats | 1984 |
Combined prazosin and hydralazine in resistant hypertension.
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Male; M | 1980 |
Current trends in the management of hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Diazoxide; Diuretics; Female; Humans; Hydralazine; Hypertension; | 1980 |
Errors in the treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Clonidine; Diuretics; Humans; Hypertension; Methyldopa; | 1980 |
Adverse drug reactions to antihypertensive therapy.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Human | 1980 |
The older patient with hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Benzothiadiazines; Blood Pressure; Blood Pressure Determin | 1980 |
A study on the effects of some drugs on DOCA induced hypertension in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Diuretics; H | 1980 |
What patients with hypertension should know about their medication.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Clonidine; Diuretics; Humans; Hydralazine; Hyp | 1980 |
Combined antihypertensive therapy: vasodilatation using prazosin in combination with beta-adrenoceptor blockers and diuretics.
Topics: Adrenergic beta-Antagonists; Diuretics; Drug Therapy, Combination; Female; Heart Rate; Humans; Hyper | 1980 |
[Minipress in the treatment of hypertension in combination with trimepranol made by Spofa. Results of a clinical study].
Topics: Adult; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Metipranolol; Middle Aged; Pra | 1980 |
[Long-term experiences in the treatment of hypertension with prazosin].
Topics: Adrenergic beta-Antagonists; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertension; Mal | 1980 |
[Thermodiagnostic assessment of the trimepranol - prazosin combination in arterial hypertension (author's transl)].
Topics: Body Temperature Regulation; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension; | 1981 |
Alpha adrenergic blockade by prazosin in therapy of essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Angiotensin II; Blood Pressure; Female; Humans; Hypertension; M | 1981 |
Indoramin.
Topics: Humans; Hypertension; Indoles; Indoramin; Prazosin | 1981 |
Prazosin in general practice.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Diuretics; Drug Therapy, Combination; Female; Humans; Hype | 1981 |
Studies on the hypotensive response to atropine in hypertensive rats.
Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Denervation; Dose- | 1981 |
Clonidine and prazosin effects in hypernoradrenergic vasodilator-treated and beta-blocker-treated patients.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Body Weight; Clonidine; Diastole; Diuretics; Female; Hu | 1981 |
[Interamerican symposium: Prazosin in arterial hypertension and cardiac insufficiency. Acapulco, Mexico, September 2-3, 1979].
Topics: Congresses as Topic; Heart Failure; Hypertension; Mexico; Prazosin; Quinazolines | 1980 |
[Prazosin and peripheral renin activity in severe arterial hypertension].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Creatinine; Diuretics; Drug Therapy, Combinati | 1980 |
[Progress in the treatment of arterial hypertension].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Diuretics; Humans; Hypertension; | 1980 |
[Alpha blockers and microcirculation (author's transl)].
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Microcirculation; Prazosin; Raynaud Disease | 1981 |
Combined alpha- and beta-adrenoceptor antagonism with prazosin and oxprenolol in control of severe hypertension in pregnancy.
Topics: Acute Disease; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Drug Therapy, Combination | 1981 |
The effects of pindolol and prazosin on hand blood flow in patients with cold extremities and on treatment with beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Cold Temperature; Female; Hand; Humans; Hypertension; | 1981 |
Prazosin as cause of urinary incontinence.
Topics: Adrenergic alpha-Antagonists; Aged; Female; Humans; Hypertension; Male; Prazosin; Pressure; Quinazol | 1981 |
[Treatment of hypertension with "minipress"].
Topics: Adrenergic beta-Antagonists; Diuretics; Humans; Hypertension; Prazosin; Quinazolines | 1981 |
[Treatment of hypertension with prazosin in ambulatory practice].
Topics: Adrenergic beta-Antagonists; Humans; Hypertension; Prazosin; Quinazolines | 1981 |
The pharmacology of prazosin, an alpha 1-adrenoceptor antagonist and the basis for its use in the treatment of essential hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Humans; Hypertension; Prazosin; Quinazolines; Receptors, Adre | 1982 |
[The present status of treatment of hypertension (author's transl)].
Topics: Adrenergic beta-Antagonists; Captopril; Clonidine; Humans; Hypertension; Nifedipine; Prazosin | 1981 |
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In | 1980 |
[Hypertension in practice--problem and therapy experiences].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Austria; Diuretics; Drug Therapy, | 1982 |
[Role of renin profile and age in the choice of the therapeutic approach of arterial hypertension (author's transl)].
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Atenolol; Chlorthalidone; Diuretics; Drug The | 1981 |
Lowering of blood pressure in hypertensive rats by SKF 64139 and SKF 72223.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Heart Rate; Hypertension; Isoquino | 1982 |
[Diurnal blood-pressure profile under Polypress therapy].
Topics: Adrenergic alpha-Antagonists; Adult; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Drug | 1982 |
Prazosin in hypertension - two years followup of 100 cases.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Child; Diuretics; Female; Follow-Up Studies; Humans; | 1982 |
Reversal of the central hypotensive effect of clonidine by intracisternal curare-like agents.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cisterna Magna; Clonidine; Decamethonium Comp | 1983 |
Haemodynamic effects of alpha-receptor blockade during acute administration and chronic treatment.
Topics: Adrenergic alpha-Antagonists; Blood Pressure; Hemodynamics; Humans; Hypertension; Prazosin; Regional | 1982 |
Hypersensitivity to prazosin.
Topics: Aged; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Hypertension; Prazosin; Quinazolines; U | 1983 |
Effect of antihypertensive agents on lipid metabolism.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazine | 1983 |
New developments in alpha-adrenergic receptor pharmacology: implications for the initial treatment of hypertension.
Topics: Adrenergic alpha-Antagonists; Catecholamines; Humans; Hypertension; Muscle, Smooth, Vascular; Prazos | 1983 |
Treating the patient with mild hypertension and renal insufficiency.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Diuretics; Humans; Hypertensio | 1983 |
[Changes in serum lipids during drug therapy of hypertension].
Topics: Adrenergic beta-Antagonists; Diuretics; Drug Therapy, Combination; Growth Hormone; Humans; Hypertens | 1982 |
Alpha-blockers and converting enzyme inhibitors.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Heart Failure; Hu | 1983 |
Postsynaptic alpha-adrenoceptors in the hypertensive rat: studies on vascular reactivity in vivo and receptor binding in vitro.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Blood Pressure; Depression, Chemical; Dose-Res | 1983 |
Beta-adrenergic receptor blocking drugs in hypertension. With special reference to their use as initial therapy.
Topics: Adrenergic beta-Antagonists; Asthma; Central Nervous System; Depression, Chemical; Heart Failure; Hu | 1984 |
Effects of prazosin on serum lipids in patients with essential hypertension: a review of the findings presented at the Satellite Symposium on coronary heart disease: hypertension and other risk factors, Milan, 1983.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Chlorthalidone; Cholesterol; Cholesterol, HDL; Coron | 1984 |
Comparison of in vitro and in vivo effects of prazosin on lipid metabolism.
Topics: Adenylyl Cyclases; Adipose Tissue; Adolescent; Adrenergic alpha-Antagonists; Adult; Blood Pressure; | 1984 |
Office management of hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Ambulatory Care; Antihypertensive Agents; Benzothiadiazines; Capt | 1984 |
Effect of clonidine at steady state on blood pressure in spontaneously hypertensive rats. Interaction of various alpha-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Benzimidazoles; Blood Pressure; Clonidine; Dioxanes; Drug Int | 1984 |
Antihypertensive activity of tibalosine (CP 804 S) in the rat. Possible involvement of a central alpha 1-adrenergic receptor blockade.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure | 1984 |
Hypertension: special concerns in geriatric patients.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Calcium Channel Blockers; Captopril; Diet, Sodium-Restrict | 1984 |
Smooth muscle alpha-2 adrenoceptors mediate vasoconstrictor responses to exogenous norepinephrine and to sympathetic stimulation to a greater extent in spontaneously hypertensive than in Wistar Kyoto rat tail arteries.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Hypertension; Idazoxan; In Vitro Techniques; Male; | 1984 |
Neurotransmitter release and vascular reactivity in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium; Catecholamines; Electric Stimulation; Guanethidine; Hypertension; | 1984 |
Calcium ions, drug action and the heart--with special reference to calcium antagonist drugs.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channe | 1984 |
The clinical pharmacology of antihypertensive drugs.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; An | 1984 |
Neuropsychiatric manifestations of antihypertensive medications.
Topics: Adrenergic beta-Antagonists; Affective Symptoms; Antihypertensive Agents; Benzothiadiazines; Clonidi | 1983 |
Orthostatic hypotension after the first administration of prazosin in hypertensive patients: role of the plasma volume.
Topics: Adolescent; Adult; Dextrans; Female; Humans; Hypertension; Hypotension, Orthostatic; Male; Middle Ag | 1981 |
Dissociation of the effects of alpha 1-adrenergic blockade on blood pressure and renin release in patients with essential hypertension.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Blood Pressure; Humans; Hypertension; Isoproterenol | 1982 |
Combined use of prazosin and beta-blockers in hypertension.
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle A | 1982 |
Effect of prazosin on blood lipids and on thyroid function in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Heart Rate; Humans; Hyperten | 1982 |
Effect of prazosin on serum lipids.
Topics: Aged; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Female; Hu | 1982 |
Open assessment of the effect of prazosin on plasma lipids.
Topics: Adult; Blood Pressure; Body Weight; Cholesterol; Cholesterol, HDL; Female; Heart Rate; Humans; Hyper | 1982 |
Effect of prazosin on lipoprotein metabolism in premenopausal, hypertensive women.
Topics: Adipose Tissue; Adult; Blood Pressure; Cholesterol; Female; Humans; Hypertension; Lipoprotein Lipase | 1982 |
Evidence of decreased plasma substance P levels in human essential hypertension and influence of prazosin treatment.
Topics: Adult; Blood Pressure; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dopamine beta-Hydroxylase; | 1983 |
Prevention of cardiac hypertrophy by long-term treatment with isosorbide dinitrate and prazosin but not by minoxidil in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Female; Hypertension; Isosorbide Dinitrate; Male; Minoxidil; | 1984 |
Biochemical alterations in cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Dihydroalprenolol; Hypertension; Myocardium; Prazosin; Protein Kinases; Rats; | 1984 |
Effects of prazosin on the cAMP system in the spontaneously hypertensive rat (SHR) aorta.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Aorta; Blood Pressure; Cycli | 1980 |
[Vasodilating agents in the treatment of hypertension - a review].
Topics: Diazoxide; Humans; Hydralazine; Hypertension; Minoxidil; Nitroprusside; Prazosin; Synaptic Transmiss | 1981 |
[Changes in blood viscosity concomitant with prazosin therapy in patients with essential arterial hypertension].
Topics: Adult; Aldosterone; Blood Pressure; Blood Viscosity; Creatinine; Female; Heart Rate; Humans; Hyperte | 1980 |
Decrease in alpha-adrenoceptor-mediated vasoconstriction parallels the antihypertensive response to propranolol in patients with normal renin essential hypertension.
Topics: Adult; Humans; Hypertension; Male; Middle Aged; Prazosin; Propranolol; Receptors, Adrenergic; Recept | 1981 |
Dietary sodium regulation of blood pressure and renal alpha 1- and alpha 2-receptors in WKY and SH rats.
Topics: Animals; Blood Pressure; Hypertension; Kinetics; Male; Prazosin; Rats; Rats, Inbred Strains; Recepto | 1981 |
Aldosterone response to antihypertensive treatment.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Antihypertensive Agents; Atenolol; Blood Pressure; Dipepti | 1982 |
Alpha-adrenoceptors, adrenaline, and exaggerated vasoconstrictor response to stress in essential hypertension.
Topics: Adult; Blood Pressure; Cold Temperature; Epinephrine; Heart Rate; Humans; Hypertension; Middle Aged; | 1983 |
Hypotensive activity of tetrandrine in rats. Investigation into its mode of action.
Topics: Alkaloids; Anesthesia; Animals; Antihypertensive Agents; Azepines; Benzylisoquinolines; Blood Pressu | 1983 |
Increased sensitivity of alpha 2-adrenoceptors mediating pressor response in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Hypertension; Male; Prazosin; Quinazolines; Rats; Rats, Inbred Strains; Rec | 1983 |
Effect of antihypertensive therapy on sympathetic nervous system activity in patients with essential hypertension.
Topics: Antihypertensive Agents; Captopril; Clonidine; Guanethidine; Humans; Hydrochlorothiazide; Hypertensi | 1984 |
Monotherapy in mild to moderate hypertension: comparison of hydrochlorothiazide, propranolol and prazosin.
Topics: Adult; Aged; Blood Pressure; Erythrocytes; Female; Heart; Heart Rate; Humans; Hydrochlorothiazide; H | 1984 |
Characterization of the alpha adrenoceptor-mediated effects and antihypertensive activity of ICI 106270: comparison with clonidine.
Topics: Animals; Antihypertensive Agents; Brain; Clonidine; Dose-Response Relationship, Drug; Guinea Pigs; H | 1984 |
Enhanced alpha-adrenoceptor-mediated vasoconstriction contributes to increased vascular resistance in essential hypertension.
Topics: Epinephrine; Humans; Hypertension; Nitroprusside; Prazosin; Receptors, Adrenergic, alpha; Synapses; | 1984 |
Supersensitivity of analgesic responses to alpha 2-adrenergic agonists in genetically hypertensive rats.
Topics: Animals; Clonidine; Hypertension; Male; Naphazoline; Pain; Prazosin; Rats; Rats, Inbred Strains; Rec | 1984 |
Pharmacologic alterations in Tc-99m binding by red blood cells: concise communication.
Topics: Animals; Blood Pressure; Captopril; Digoxin; Drug Interactions; Erythrocytes; Female; Hematocrit; Hy | 1983 |
Blood pressure changes in spontaneously hypertensive rats correlate with aortic prostacyclin formation.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Clonidine; Dihydralazine; Epopros | 1983 |
Cardiovascular consequences of primary antihypertensive therapy with prazosin hydrochloride.
Topics: Adult; Blood Pressure; Erythrocytes; Female; Heart; Hemodynamics; Humans; Hypertension; Male; Middle | 1984 |
Comparative effects of propranolol and prazosin upon serum lipids in thiazide- treated hypertensive patients.
Topics: Adult; Blood Pressure; Cholesterol; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertens | 1984 |
Effects of long-term prazosin therapy on lipoprotein metabolism in hypertensive patients.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Female; Humans; Hypertension; Lipoproteins; Male; Middle A | 1984 |
Use of calcium antagonists as monotherapy in the management of hypertension.
Topics: Calcium; Calcium Channel Blockers; Humans; Hypertension; Nicardipine; Nifedipine; Nitroprusside; Pra | 1984 |
[Initial and long-term therapy of hypertension using Polypress].
Topics: Antihypertensive Agents; Drug Combinations; Female; Humans; Hypertension; Long-Term Care; Male; Poly | 1983 |
Acute hypotensive response to nifedipine added to prazosin in treatment of hypertension.
Topics: Adult; Drug Therapy, Combination; Humans; Hypertension; Hypotension; Male; Nifedipine; Prazosin; Qui | 1983 |
[Clinical use of new antihypertensives].
Topics: Alkaloids; Antihypertensive Agents; Benzylisoquinolines; Captopril; Diazoxide; Diterpenes; Humans; H | 1984 |
[Antihypertensives and the prevention of development of genetic hypertension in the hypertensive SHR rat].
Topics: Animals; Antihypertensive Agents; Atenolol; Captopril; Cardiomegaly; Dihydralazine; Dose-Response Re | 1980 |
Systemic and regional hemodynamic effects of acute and prolonged treatment with urapidil or prazosin in normotensive and spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Dose-Response Relationship, Drug; | 1984 |
Acute systemic and regional haemodynamic profile of prazosin in conscious hypertensive rabbits.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Hydrogen-Ion | 1984 |
Prazosin-induced priapism in a diabetic.
Topics: Adult; Diabetes Mellitus, Type 1; Humans; Hypertension; Male; Prazosin; Priapism; Quinazolines | 1984 |
[Antihypertensive effectiveness of a domestically manufactured preparation of prazosin (Prazosin VUFB)].
Topics: Humans; Hypertension; Prazosin; Quinazolines | 1984 |
Prazosin ('Peripress'): a long-term study.
Topics: Adult; Aged; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines; Time Factors | 1984 |
Identification of a prazosin metabolite and some preliminary data on its kinetics in hypertensive patients.
Topics: Adult; Half-Life; Humans; Hypertension; Kinetics; Male; Middle Aged; Prazosin; Quinazolines | 1984 |
New potent antihypertensive agents, or H3088 and or N0676.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hype | 1983 |
An unusual young male with exercise induced, severe hypertensive spikes. What's the diagnosis?
Topics: Adult; Drug Therapy, Combination; Furosemide; Humans; Hypertension; Male; Minoxidil; Physical Exerti | 1983 |
Cerebral blood flow in hypertension.
Topics: Antihypertensive Agents; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Disorders; Dia | 1983 |
The effect of chronic hypertension and antihypertensive drugs on the cerebral circulation.
Topics: Animals; Antihypertensive Agents; Cerebrovascular Circulation; Diazoxide; Dihydralazine; Homeostasis | 1983 |
Prazosin in hypertension associated with chronic renal failure.
Topics: Adolescent; Adult; Follow-Up Studies; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Middle | 1983 |
Prazosin-induced bradycardia in acute treatment of hypertension.
Topics: Adult; Aged; Blood Pressure; Bradycardia; Female; Heart Rate; Humans; Hypertension; Male; Middle Age | 1983 |
Clinical pharmacological studies with prazosin during pregnancy complicated by hypertension.
Topics: Adolescent; Adult; Female; Humans; Hypertension; Prazosin; Pregnancy; Pregnancy Complications, Cardi | 1983 |
Clonidine and prazosin in the treatment of hypertensive outpatients--a preliminary study.
Topics: Adult; Ambulatory Care; Blood Pressure; Clonidine; Drug Therapy, Combination; Drug Tolerance; Electr | 1983 |
The use of systolic time intervals in the evaluation of antihypertensive treatment with metoprolol, labetalol and prazosin.
Topics: Adult; Aged; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Metoprolol; Middle Aged; | 1983 |
[Prazosin in moderate or severe essential arterial hypertension not controlled with chlorthalidone. A multicenter study].
Topics: Adult; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Humans; Hypertension; Male | 1983 |
Haemodynamic response to ketanserin in rabbits with Page hypertension: comparison with prazosin.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Hypertension; K | 1983 |
[Non-invasive hemodynamic study of the acute oral administration of prazosin in stages I and II arterial hypertension].
Topics: Administration, Oral; Adult; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Middle | 1983 |
Prazosin as initial antihypertensive therapy: correlates of sympathetic function.
Topics: Adult; Blood Pressure; Epinephrine; Female; Humans; Hypertension; Male; Middle Aged; Norepinephrine; | 1984 |
Treatment of hypertension in diabetic men: problems with sexual dysfunction.
Topics: Antihypertensive Agents; Blood Pressure; Diabetic Angiopathies; Erectile Dysfunction; Humans; Hydroc | 1984 |
Prazosin versus propranolol plus prazosin: a comparison in diuretic-treated hypertensive patients.
Topics: Aged; Blood Pressure; Drug Therapy, Combination; Heart Rate; Humans; Hydrochlorothiazide; Hypertensi | 1984 |
Coronary heart disease: hypertension and other risk factors. Proceedings of a satellite symposium of the first European Meeting on Hypertension.
Topics: Coronary Disease; Humans; Hypertension; Lipid Metabolism; Prazosin; Risk | 1984 |
Effect of prazosin on blood pressure and plasma lipids in patients receiving a beta-blocker and diuretic regimen.
Topics: Aged; Blood Pressure; Chlorthalidone; Cholesterol; Drug Therapy, Combination; Female; Humans; Hypert | 1984 |
Comparative effects of prazosin and atenolol on plasma lipids in hypertensive patients.
Topics: Adult; Atenolol; Blood Pressure; Cholesterol; Female; Heart Rate; Humans; Hypertension; Lipid Metabo | 1984 |
Hypertensive crisis in prazosin-treated pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Catecholamines; Female; Humans; Hypertension; Middle Aged; Phenoxybenzamine | 1984 |
[Causes of acute valve-conditioned left ventricular insufficiency-- attempt at a tabulated review].
Topics: Aortic Valve Insufficiency; Cardiac Glycosides; Dyspnea; Endocarditis, Bacterial; Humans; Hydralazin | 1984 |
[Effect of single dose of prazosin on the indicators of central hemodynamics].
Topics: Adult; Blood Pressure; Blood Volume; Heart Rate; Hemodynamics; Humans; Hypertension; Middle Aged; Pr | 1984 |
[Hypertensive therapy with prazosin. Concomitant cardiovascular, metabolic and respiratory diseases. Proven facts and potential aspects].
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Cardiovascular Diseases; Diabetes Complications; Humans; Hy | 1984 |
Timolol/bendrofluazide combination ('Prestim') in the treatment of poorly controlled hypertensive patients in general practice.
Topics: Adult; Aged; Antihypertensive Agents; Bendroflumethiazide; Blood Pressure; Drug Combinations; Family | 1984 |
Effects of prazosin therapy on BP, renal function, and body fluid composition.
Topics: Blood Pressure; Body Fluids; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Male; Middle | 1984 |
Hypertension, vascular headaches, and seizures after carotid endarterectomy. Case report and therapeutic considerations.
Topics: Carotid Arteries; Endarterectomy; Female; Humans; Hypertension; Middle Aged; Phenobarbital; Prazosin | 1984 |
[Recent antihypertensive agents].
Topics: Antihypertensive Agents; Guanfacine; Guanidines; Humans; Hypertension; Labetalol; Minoxidil; Phenyla | 1982 |
[Effect of prazosin on catecholamines, renin-aldosterone system and prostaglandins in primary hypertension].
Topics: Adult; Aldosterone; Catecholamines; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Prost | 1982 |
Vasodilators in the treatment of hypertension.
Topics: Calcium Channel Blockers; Captopril; Diazoxide; Humans; Hydralazine; Hypertension; Minoxidil; Nitrop | 1982 |
[Effects of acute and chronic vasodilator administration on hemodynamics and catecholamine concentration in chronic left heart failure (author's transl)].
Topics: Blood Pressure; Cardiac Output; Cardiomyopathies; Catecholamines; Coronary Disease; Dopamine; Epinep | 1980 |
A clinical study with prazosin and polythiazide (Minizide) in the treatment of hypertension.
Topics: Adult; Aged; Drug Combinations; Female; Humans; Hypertension; Male; Middle Aged; Polythiazide; Prazo | 1982 |
Effectiveness of prazosin as initial antihypertensive therapy.
Topics: Blood Pressure; Drug Administration Schedule; Humans; Hypertension; Kidney; Lipid Metabolism; Prazos | 1983 |
New approaches to the therapy of mild hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Catecholamines; Diuretics; Glucose Tolerance Test; Humans; | 1983 |
Self-poisoning with prazosin.
Topics: Aged; Humans; Hypertension; Male; Prazosin; Quinazolines; Self Administration | 1983 |
Disparate effects of prazosin and propranolol on lipid metabolism in a rat model.
Topics: Animals; Cholesterol; Disease Models, Animal; Hypertension; Lipid Metabolism; Lipoproteins, VLDL; Ma | 1983 |
Acute oral management of hypertension: blood pressure response to prazosin and nifedipine.
Topics: Blood Pressure; Humans; Hypertension; Hypotension, Orthostatic; Middle Aged; Nifedipine; Prazosin; P | 1983 |
[Treatment of hypertension with prazosin in the perioperative phase].
Topics: Aged; Anesthesia, General; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Middle Ag | 1983 |
Prazosin and oxprenolol therapy in pregnancy hypertension.
Topics: Blood Pressure; Drug Therapy, Combination; Female; Humans; Hypertension; Oxprenolol; Prazosin; Pregn | 1983 |
Effects of tiodazosin, a new antihypertensive, hemodynamics and clinical variables.
Topics: Adult; Blood Chemical Analysis; Blood Pressure; Body Weight; Cardiac Output; Drug Evaluation; Electr | 1983 |
Prazosin hydrochloride.
Topics: Adult; Animals; Child; Dogs; Female; Humans; Hypertension; Male; Prazosin; Pregnancy; Quinazolines | 1980 |
Four to seven-year follow-up of patients on prazosin. New Zealand Hypertension Study Group.
Topics: Adult; Aged; Blood Pressure; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; New | 1980 |
Complications in long term treatment of essential hypertension.
Topics: Benzothiadiazines; Diuretics; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Myocardia | 1981 |
Hydralazine in chronic CHF.
Topics: Administration, Oral; Aortic Valve Insufficiency; Cardiac Output; Chronic Disease; Drug Therapy, Com | 1981 |
Antihypertensive treatment and fetal welfare in essential hypertension in pregnancy: a retrospective survey of experience with various regimes at National Women's Hospital, Auckland, 1970-80.
Topics: Antihypertensive Agents; Bed Rest; Benzothiadiazines; Birth Weight; Diuretics; Drug Therapy, Combina | 1982 |
Prazosin and ANA.
Topics: Antibodies, Antinuclear; Humans; Hypertension; Prazosin; Quinazolines | 1981 |
Acute tolerance to prazosin in conscious hypertensive rats: involvement of the renin-angiotensin system.
Topics: Angiotensin II; Animals; Captopril; Cardiovascular Agents; Clonidine; Dose-Response Relationship, Dr | 1981 |
[Treatment of severe resistant arterial hypertension with captopril. 58 patients, including 38 treated for more than 6 months (author's transl)].
Topics: Adult; Aged; Atenolol; Captopril; Diet, Sodium-Restricted; Drug Therapy, Combination; Female; Humans | 1981 |
[Effects of prazosin on the control of arterial pressure in hypertensive patients subjected to dialysis].
Topics: Blood Volume; Female; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Prazosin; Quinazolin | 1980 |
[Blood insulin and glucose in essential hypertension treated with prazosin].
Topics: Adult; Blood Glucose; Female; Humans; Hypertension; Insulin; Male; Middle Aged; Prazosin | 1981 |
The effect of oral prazosin on blood pressure and plasma concentrations of renin and angiotensin II in man.
Topics: Administration, Oral; Adult; Angiotensin II; Blood Pressure; Female; Humans; Hypertension; Male; Mid | 1981 |
Pheochromocytoma, diagnosis and treatment update and case report.
Topics: Adrenal Gland Neoplasms; Humans; Hypertension; Male; Middle Aged; Nitroprusside; Pheochromocytoma; P | 1982 |
The addition of prazosin to standard triple therapy in the treatment of severe hypertension.
Topics: Adult; Aged; Bendroflumethiazide; Blood Pressure; Drug Therapy, Combination; Electrocardiography; Fe | 1982 |
Hypertension in older patients: what drugs to use and when.
Topics: Aged; Antihypertensive Agents; Clonidine; Diuretics; Humans; Hypertension; Hypotension, Orthostatic; | 1982 |
[Use of the new hypotensive agent Minipress (prazosin hydrochloride].
Topics: Adult; Antihypertensive Agents; Chronic Disease; Drug Evaluation; Female; Hemodynamics; Humans; Hype | 1982 |
Prazosin first dose phenomenon during combined treatment with a beta-adrenoceptor blocker in hypertensive patients.
Topics: Adult; Alprenolol; Blood Pressure; Drug Interactions; Drug Therapy, Combination; Female; Heart Rate; | 1982 |
Prazosin and propranolol in preoperative management of pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Drug Therapy, Combination; Female; Humans; Hypertension; | 1982 |
[Prazosin: clinical use in the treatment of arterial hypertension and cardiac insufficiency].
Topics: Heart Failure; Humans; Hypertension; Prazosin; Quinazolines | 1982 |
[Multicenter evaluation of the antihypertensive action of prazosin].
Topics: Adult; Diuretics; Drug Evaluation; Drug Therapy, Combination; Drug Tolerance; Humans; Hypertension; | 1982 |
[Effect of prazosin on changes in blood lipids].
Topics: Coronary Disease; Humans; Hyperlipoproteinemia Type IV; Hypertension; Lipoproteins, HDL; Lipoprotein | 1982 |
Prazosin and priapism.
Topics: Adult; Humans; Hypertension; Male; Prazosin; Priapism; Quinazolines | 1982 |
[Hemodynamic and humoral effects of prazosin in patients with essential hypertension].
Topics: Adult; Aged; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines | 1982 |
[Evaluation of the hypotensive action of prazosin by continuous recording of arterial pressure].
Topics: Blood Pressure Determination; Humans; Hypertension; Monitoring, Physiologic; Prazosin; Quinazolines | 1981 |
Pharmacologic approach to the management of childhood hypertension.
Topics: Antihypertensive Agents; Autonomic Nervous System; Central Nervous System; Child; Diazoxide; Humans; | 1981 |
[Enhanced alpha adrenoreceptor-mediated vasoconstrictor component in essential hypertension].
Topics: Adult; Aged; Blood Pressure; Drug Synergism; Female; Ferricyanides; Forearm; Heart Rate; Humans; Hyp | 1980 |
Correlation between decreased heart rate and central inhibition of sympathetic discharge after prazosin administration in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Cardiovascular System; Heart Rate; Hydralazine; Hypertension; Male; Prazosi | 1981 |
[Mesenteric syndrome following the repair of aortic coarctation. Pathogenetic and clinical findings].
Topics: Adolescent; Adult; Aortic Coarctation; Child; Child, Preschool; Duodenal Obstruction; Female; Heart | 1981 |
Prazosin HCl in treating hypertension associated with pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Aged; Humans; Hypertension; Male; Pheochromocytoma; Prazosin; Quinazolines | 1981 |
[Prazosin in the treatment of arterial hypertension].
Topics: Adult; Antihypertensive Agents; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; | 1980 |
[Usefulness of prazosin in the treatment of hypertensive patients with low cardiac output].
Topics: Adult; Aged; Cardiac Catheterization; Cardiac Output, Low; Digoxin; Female; Heart Function Tests; He | 1980 |
[Long-term antihypertensive treatment with prazosin in combination with a diuretic].
Topics: Adult; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Hyp | 1980 |
[Control of arterial hypertension at the work site of the patient: retrospective review of prazosin and propanolol].
Topics: Adult; Aged; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Occupational Heal | 1980 |
[Clinical observations on 80 cases treated with prazosin alone and in combination with other antihypertensive agents].
Topics: Adult; Aged; Antihypertensive Agents; Creatinine; Diuretics; Drug Therapy, Combination; Female; Huma | 1980 |
[Elimination of a therapeutic step in the treatment of severe arterial hypertension].
Topics: Humans; Hypertension; Prazosin; Quinazolines | 1980 |
Prazosin kinetics in hypertension.
Topics: Adult; Biological Availability; Blood Proteins; Female; Humans; Hypertension; Kidney; Kinetics; Male | 1981 |
Prazosin dynamics in hypertension: relationship to plasma concentration.
Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Male; Middle | 1981 |
Prazosin. Long-term treatment of moderate and severe hypertension and lack of "tolerance".
Topics: Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Drug Tolerance; Female; Humans; | 1981 |
Treatment of Essential hypertension with single daily doses of a prazosin-polythiazide combination: a multicentre study with Minizide.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Drug Combinations; Female; Humans; Hypertension; M | 1981 |
Sustained antihypertensive response with Minizide: long-term follow-up in a multicentre study.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Drug Combinations; Female; Follow-Up Studies; Huma | 1981 |
[Antihypertensive activity of minoxidil, hydralazine, prazosin, phentolamine and clonidine in spontaneously hypertensive rats. Comparison with therapeutic dosages].
Topics: Animals; Antihypertensive Agents; Clonidine; Hydralazine; Hypertension; Minoxidil; Phentolamine; Pra | 1981 |
Effects of chronic prazosin treatment on the renin-angiotensin-aldosterone system in man.
Topics: Adult; Blood Pressure; Drug Administration Schedule; Female; Heart Rate; Humans; Hypertension; Male; | 1981 |
[Prazosin in combination with various conventional antihypertensives].
Topics: Adult; Aged; Antihypertensive Agents; Drug Therapy, Combination; Female; Humans; Hypertension; Male; | 1981 |
Lack of antagonism in the antihypertensive effects of clonidine and prazosin in man.
Topics: Adult; Aged; Clonidine; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; | 1981 |
Prazosin in hypertension: crossover comparison with methyldopa and long-term efficacy.
Topics: Drug Evaluation; Humans; Hypertension; Methyldopa; Prazosin; Quinazolines; Random Allocation | 1981 |
[Prazosin in the treatment of arterial hypertension].
Topics: Blood Pressure; Humans; Hypertension; Prazosin; Quinazolines | 1981 |
Physiologic effects of prazosin HCl: consequences of diuretic combination therapy.
Topics: Adult; Blood Pressure; Cardiac Volume; Drug Combinations; Female; Hemodynamics; Humans; Hypertension | 1981 |
[Prazosin (Peripress) in hypertension].
Topics: Humans; Hypertension; Prazosin; Quinazolines | 1981 |
Rapid control of serious high blood pressure with single large oral doses of prazosin.
Topics: Administration, Oral; Humans; Hypertension; Prazosin; Quinazolines; Time Factors | 1980 |
Prazosin (minipress): a review.
Topics: Humans; Hypertension; Prazosin; Quinazolines | 1980 |
Prazosin kinetics and effectiveness in renal failure.
Topics: Adult; Aged; Blood Pressure; Blood Proteins; Dose-Response Relationship, Drug; Female; Humans; Hyper | 1980 |
Special considerations in treating hypertension in the elderly.
Topics: Aged; Clonidine; Diet, Sodium-Restricted; Diuretics; Guanethidine; Humans; Hydralazine; Hypertension | 1980 |
Prazosin kinetics in essential hypertension.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Female; Half-Life; Humans; Hyperte | 1980 |
Use of labetalol in moderate to severe hypertension.
Topics: Benzothiadiazines; Diuretics; Drug Therapy, Combination; Ethanolamines; Female; Humans; Hypertension | 1980 |
Synthesis and blood pressure lowering activity of 3-(substituted-amino)-1,2,4-benzothiadiazine 1-oxide derivatives.
Topics: Animals; Antihypertensive Agents; Benzothiadiazines; Hypertension; Male; Prazosin; Rabbits; Rats; St | 1980 |
[The hypotensive effect of prazosin].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Hypotension, Orthostatic; Midd | 1980 |
[Antihypertensive effects of hydroflumethiazide and prazosin].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Hydroflumethiazide; Hypertension; Male; Midd | 1980 |
Prediction of response to antihypertensive therapy with prazosin.
Topics: Adult; Blood Pressure; Humans; Hypertension; Middle Aged; Prazosin; Quinazolines | 1980 |
Continuous blood pressure measurement in ambulatory patients in the assessment of prazosin regimens.
Topics: Adult; Blood Pressure; Humans; Hypertension; Middle Aged; Prazosin; Quinazolines | 1980 |
Prazosin in renal impairment.
Topics: Blood Pressure; Humans; Hypertension; Hypertension, Renal; Prazosin; Quinazolines | 1980 |
Role of prazosin in moderate hypertension.
Topics: Adult; Aged; Humans; Hypertension; Middle Aged; Prazosin; Quinazolines | 1980 |
Vasodilator drugs and resistant hypertension.
Topics: Antihypertensive Agents; Diazoxide; Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Mi | 1980 |
[Thermodiagnostic evaluation of prazosin effects in arterial hypertension (author's transl)].
Topics: Blood Pressure; Body Temperature Regulation; Humans; Hypertension; Male; Middle Aged; Prazosin; Quin | 1980 |
Monoamine metabolites in cerebrospinal fluid during treatment of hypertension with prazosin.
Topics: Biogenic Amines; Blood Pressure; Female; Humans; Hypertension; Male; Methoxyhydroxyphenylglycol; Pra | 1980 |
Physiologic mechanisms opposing the hemodynamic effects of prazosin.
Topics: Adult; Blood Pressure; Extracellular Space; Female; Heart Rate; Hemodynamics; Humans; Hypertension; | 1981 |
The management of hypertension in pregnancy.
Topics: Adult; Dihydralazine; Drug Therapy, Combination; Female; Humans; Hypertension; Oxprenolol; Prazosin; | 1981 |
Complications of antihypertensive therapy.
Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydr | 1981 |
Antihypertensive effects of AT-112, a newly synthesized quinazoline derivative, in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitiv | 1995 |
Functional autoimmune epitope on alpha 1-adrenergic receptors in patients with malignant hypertension.
Topics: Adult; Animals; Autoantibodies; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Humans; Hyperte | 1994 |
Terazosin for BPH.
Topics: Adrenergic alpha-Antagonists; Clinical Trials as Topic; Humans; Hypertension; Male; Prazosin; Prosta | 1995 |
[The reactivity of the mesenteric arteries and vein to exposure to endogenous noradrenaline in normal rats and rats with DOCA-salt hypertension].
Topics: Animals; Desoxycorticosterone; Electric Stimulation; Hypertension; Male; Mesenteric Arteries; Mesent | 1994 |
Hytrin treatment of hypertension and benign prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Male; Prazosin; Prostatic Hyperplasia | 1995 |
Alterations of alpha 1-adrenergic receptor densities in right and left ventricles of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Body Weight; Dogs; Heart Ventricles; Hyperten | 1995 |
[Comparison of the effectiveness of sublingual administration of capoten and prazosin in the treatment of hypertensive crises].
Topics: Administration, Sublingual; Captopril; Humans; Hypertension; Prazosin | 1995 |
Contribution of alpha- and beta- adrenoceptors and neuropeptide-Y to autonomic dysreflexia.
Topics: Animals; Autonomic Nervous System Diseases; Blood Pressure; Ganglionic Blockers; Heart Rate; Hexamet | 1995 |
Alpha 1-adrenoceptor subtypes and inositol phosphates production in heart ventricles of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Heart Ventricles; Hypertension; Inositol | 1993 |
cAMP and protein synthesis in isolated adult rat heart preparations.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Depende | 1993 |
Endothelin-1 in rat periaqueductal gray area induces hypertension via glutamatergic receptors.
Topics: Animals; Blood Pressure; Drug Interactions; Endothelins; Hypertension; Male; Microinjections; Periaq | 1995 |
Effects of propranolol and atenolol on immobilization stress-induced hypertension and down-regulation of central beta-adrenoceptors in rats.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Blood Pressure; Cerebral Cortex; Dihydroalprenolol; | 1995 |
An individualized approach to the hypertensive patient with renal disease: six illustrative case studies.
Topics: Adrenergic alpha-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Arterial Occlusive Dis | 1995 |
Alpha-adrenoceptor modulation of norepinephrine and ATP release in isolated kidneys of spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Hypertension; Kidney; Norepinephrine; Prazosi | 1995 |
Hemodynamic and neural effects of urapidil and prazosin in essential hypertensives.
Topics: Administration, Oral; Antihypertensive Agents; Blood Pressure; Heart Rate; Humans; Hypertension; Per | 1994 |
Effect of chronic treatment with prazosin and L-arginine on the elevation of blood pressure during cold exposure.
Topics: Adrenal Glands; Angiotensin II; Animals; Arginine; Blood Pressure; Cardiomegaly; Cold Temperature; E | 1994 |
Clinical applications of alpha 1-receptor blockade: terazosin in the management of hypertension. Introduction.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Prazosin; Receptors, Adrenergic, alpha-1 | 1993 |
[Effect of enalapril and terazosin on lipid metabolism in patients with essential arterial hypertension and accompanying hypercholesterolemia].
Topics: Adrenergic alpha-Antagonists; Adult; Enalapril; Female; Humans; Hypercholesterolemia; Hypertension; | 1993 |
[The effect of terazosin and nitrendipine on blood insulin, glucose and lipid in SHR rats].
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Female; Hypertension; Insulin; Lipids; Prazosi | 1993 |
Long-term alpha-1 adrenoceptor blockade does not affect plasma atrial natriuretic peptide in hypertensive patients.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Atrial Natriuretic Fac | 1994 |
Diaspirin crosslinked hemoglobin (DCLHb): control of pressor effect with anti-hypertensive agents.
Topics: Animals; Antihypertensive Agents; Aspirin; Blood Pressure; Blood Substitutes; Hemoglobins; Hypertens | 1994 |
Acute effects of ethanol on cardiac output and its derivatives in spontaneously hypertensive and normotensive rats.
Topics: Animals; Blood Pressure; Cardiac Output; Ethanol; Hypertension; Prazosin; Propranolol; Rats; Rats, I | 1994 |
A possible mechanism of action of a new potassium channel opener, AL0671, on lipid metabolism in obese Zucker rats.
Topics: Animals; Bridged Bicyclo Compounds; Guanidines; Hypertension; Hypolipidemic Agents; Lipase; Lipid Me | 1994 |
Management of hypertension in diabetes.
Topics: Antihypertensive Agents; Combined Modality Therapy; Diabetes Complications; Diabetes Mellitus; Human | 1993 |
TxA2-PGI2-PGF2 alfa responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension.
Topics: Adolescent; Adult; Blood Pressure; Dinoprost; Epoprostenol; Female; Gallopamil; Glomerular Filtratio | 1993 |
Salt-sensitive hypertension caused by long-term alpha-adrenergic blockade in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Drinking; Heart Rate; Hypertension; Male; Natriuresis; Phenyl | 1993 |
Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Felodipine | 1993 |
Characterization of the alpha-1 adrenoceptors in the mesenteric vasculature from deoxycorticosterone-salt hypertensive rats: studies on vasoconstriction, radioligand binding and postreceptor events.
Topics: Animals; Calcium; Desoxycorticosterone; Hypertension; In Vitro Techniques; Inositol 1,4,5-Trisphosph | 1994 |
[Weak transplacental passage of prazosin (Alpress) during the third trimester of pregnancy. 3 cases].
Topics: Adult; Delayed-Action Preparations; Drug Monitoring; Female; Fetal Blood; Humans; Hypertension; Mate | 1993 |
Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl | 1994 |
Angiotensin II alters aortic fibronectin independently of hypertension.
Topics: Angiotensin II; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Fibronectins; Humans; Hydralazin | 1994 |
Sex hormones change adrenoceptors in blood vessels of the spontaneously hypertensive rat.
Topics: Animals; Arteries; Blood Pressure; Dihydroalprenolol; Hypertension; Isoproterenol; Kinetics; Male; N | 1993 |
Increased alpha 1-adrenergic vascular sensitivity during development of hypertension in conscious dogs.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Cell Membrane; Consciousness; Dogs; Female; Hyperten | 1993 |
Hemodynamic effects on thrombogenesis and platelet aggregation in spontaneously hypertensive rats.
Topics: Animals; Collagen; Endothelium, Vascular; Hemodynamics; Hypertension; In Vitro Techniques; Male; Pla | 1993 |
[Effect of long term prazosin treatment on secretion of insulin, glucagon, gastrin, and pancreatic polypeptide in patients with essential hypertension].
Topics: Adolescent; Adult; Drug Administration Schedule; Female; Gastrins; Humans; Hypertension; Male; Middl | 1993 |
[The effect of long-term prazosin treatment on plasma follitropin (FSH), lutropin (LH), prolactin, estradiol and testosterone concentration in male patients with essential hypertension].
Topics: Adult; Drug Administration Schedule; Estradiol; Follicle Stimulating Hormone; Hormones; Humans; Hype | 1993 |
[Pharma-clinics. Drug of the month. Terazosine (Hytrin)].
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Humans; Hypertension; Male; Middle Aged; Praz | 1995 |
[Evidence for two alpha 2B-adrenoreceptor isoforms in the renal cortex of salt-sensitive and salt resistant Sabra rats. Effect of salt loading].
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Guanabenz; Hyp | 1995 |
Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Facial Bones; Female; Fetal Death; Fetus; Huma | 1995 |
Preweanling administration of terazosin decreases blood pressure of hypertensive rats in adulthood.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Suckling; Blood Pressure; Drug Administration | 1996 |
[The effect of cilazapril and prazosin on insulin sensitivity in patients with essential hypertension].
Topics: Angiotensin-Converting Enzyme Inhibitors; Cilazapril; Female; Glucose Tolerance Test; Humans; Hypert | 1995 |
Pharmacological activity of DC-015, a novel potent and selective alpha 1-adrenoceptor antagonist.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age | 1996 |
Low concentrations of angiotensin II unmask vasoconstrictory alpha 2-adrenoceptors in isolated perfused kidneys of spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Re | 1995 |
Insight into blood-pressure control in SHR via the response to acute hemorrhage: a spectral analysis approach.
Topics: Acute Disease; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin-Co | 1995 |
Noradrenergic transmission in the tail artery of hypertensive rats transgenic for the mouse renin gene Ren-2.
Topics: Animals; Animals, Genetically Modified; Arteries; Electric Stimulation; Hypertension; Male; Mice; No | 1996 |
Contribution of the sympathetic nervous system to hypertensive response to insulin excess in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Clonidine; Ganglion | 1996 |
Effect of nifedipine, captopril and prazosin on secretory function of pancreatic beta-cells in hypertensive patients with type-2 (non-insulin-dependent) diabetes and in hypertensive non-diabetics.
Topics: Adult; Antihypertensive Agents; Blood Glucose; C-Peptide; Calcium Channel Blockers; Captopril; Diabe | 1996 |
Oral therapy with combined enalapril, prazosin and hydrochlorothiazide in the acute treatment of severe hypertension in Nigerians.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Angiotensin-Convert | 1996 |
In vitro inhibitory effects of chebulinic acid on the contractile responses of cardiovascular muscles.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Dogs; Dose-Response | 1996 |
Effect of episodic eucapnic and hypocapnic hypoxia on systemic blood pressure in hypertension-prone rats.
Topics: Animals; Antihypertensive Agents; Arousal; Atropine; Blood Pressure; Cardiovascular Agents; Heart Ra | 1996 |
[In what sense are alpha 1-receptor blockers as first choice agents in treatment of hypertension suitable?].
Topics: Adrenergic alpha-Antagonists; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Ad | 1996 |
Chronic adrenergic receptor blockade does not prevent hyperinsulinemia-induced hypertension in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Blood Pressure; D | 1996 |
Scorpion envenoming and the cardiovascular system.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Animals; Antihypertensive Agents; Cardiovascular Di | 1997 |
Alpha 1-adrenergic receptor antibodies in patients with primary hypertension.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Anta | 1997 |
alpha-receptor blockade for benign prostatic hyperplasia: uses and problems in a developing country.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Heart Diseases; Humans; Hypertension; Male; M | 1997 |
Autonomic blockade amplifies cortisol-induced hypertension in man.
Topics: Adrenergic alpha-Antagonists; Adult; Autonomic Nerve Block; Autonomic Nervous System; Blood Pressure | 1997 |
Does the neuropeptide Y Y1 receptor contribute to blood pressure control in the spontaneously hypertensive rat?
Topics: Animals; Arginine; Blood Pressure; Electric Stimulation; Heart Rate; Hypertension; Male; Neuropeptid | 1997 |
Effect of haemorrhage on the power of low frequency blood pressure fluctuations in young spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1995 |
Metyrosine and pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; alph | 1997 |
Pheochromocytoma during pregnancy: case report.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Female; Humans; Hypertension; Pheochromocytoma; Prazo | 1997 |
Mechanisms in the pressor effects of hepatic portal venous fatty acid infusion.
Topics: Acetylcholine; Aldosterone; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pre | 1997 |
Sympathetic nervous system and hypertension during prolonged TxA2/PGH2 receptor activation in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents | 1997 |
Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifl | 1997 |
Parodoxical rise in urinary albumin levels after treatment of essential hypertension.
Topics: Adult; Aged; Albuminuria; Antihypertensive Agents; Creatinine; Female; Humans; Hydroflumethiazide; H | 1997 |
Differences between the effects of metoprolol and prazosin on the forearm vasculature in primary hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Catecholamines; Female; Forearm; H | 1997 |
[Intraoperative diagnosis of a multilocal pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Anesthesia | 1997 |
Pheochromocytoma in pregnancy manifesting hypertensive crisis induced by metoclopramide.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adult; Antiemetics; Female; Humans; Hypertens | 1997 |
Influence of sympathetic blockade on the acute hypertensive response to aortic constriction.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Abdominal; Aortic Coarctation; Blood Pressu | 1997 |
Beat-to-beat fluctuations in the BP related signals in rats: can it contribute to the understanding of the development of hypertension?
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Diastole; Heart Rate; Hypertension; Male; Pra | 1998 |
Altered muscle metabolism associated with vasoconstriction in spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Glucose; Hypertension; Lactic Acid | 1998 |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apamin; Biological Factors; Brimon | 1998 |
Antihypertensive mechanisms underlying a novel salt-sensitive hypertensive model induced by sensory denervation.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blood Pressure; Body Weight; Calcitonin Gene-Rel | 1999 |
Alpha1- and alpha2-adrenoceptor control of sodium transport reverses in developing hypertension.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Biological Transport; Cells, Cultured; Hypertension; K | 1999 |
Prescribing and usage patterns of two antihypertensive agents: a comparison of terazosin and enalapril.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; D | 1991 |
Blood pressure variability in established L-NAME hypertension in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Losartan; Male; N | 1999 |
[Sublingual captopril: indications and advantages?].
Topics: Administration, Oral; Administration, Sublingual; Adrenergic alpha-Antagonists; Angiotensin-Converti | 2000 |
NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agon | 2000 |
Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Blood Pressure D | 2000 |
Effects of antihypertensive treatment on platelet function in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; bet | 2000 |
Antihypertensive monotherapy and cardiovascular responses to an acoustic startle stimulus.
Topics: Acoustic Stimulation; Adrenergic alpha-Agonists; Analysis of Variance; Antihypertensive Agents; Aten | 2001 |
Mechanisms of the increased pressor response to vasopressors in the mesenteric bed of nitric oxide-deficient hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; D | 2001 |
The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production.
Topics: Adrenergic alpha-Antagonists; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihyperten | 2001 |
Autonomic studies in hypertensive patient with unusual sexual dysfunction: response to reserpine.
Topics: Autonomic Nervous System; Blood Pressure; Cold Temperature; Dose-Response Relationship, Drug; Drug T | 2000 |
Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study.
Topics: Accidental Falls; Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Cohort Studies; Comor | 2001 |
Researcher, clinician, or teacher?
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Humans; Hypertension; India; Prazosi | 2001 |
Alpha1-adrenergic receptor subtypes in peripheral blood lymphocytes of essential hypertensives.
Topics: Adult; Animals; Aorta; Female; Humans; Hypertension; Lymphocytes; Male; Middle Aged; Prazosin; Prote | 2001 |
Antihypertensive action and blockade of alpha1-adrenoceptors by DL-017, a quinazoline derivative.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Cerebral Cortex; Cerebr | 2001 |
Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Gene Expression Re | 2002 |
Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Animals; Antihypertensive Agen | 2002 |
Alpha2 -adrenoceptor function in arterial hypertension associated with obesity in dogs fed a high-fat diet.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood | 2002 |
Drug treatment of hypertension.
Topics: Clonidine; Diazoxide; Diuretics; Ganglionic Blockers; Guanethidine; Humans; Hydralazine; Hypertensio | 1977 |
Long-term use of prazosin in combination or alone for treating hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Clonidine; Drug Therapy, Combination; F | 1977 |
The pharmacology of antihypertensive drugs with special reference to vasodilators, alpha-adrenergic blocking agents and prazosin.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Carotid Sinus; Dogs; Epinephrine; Hu | 1977 |
Prazosin in the treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Humans; Hypert | 1977 |
The role of prazosin in the management of hypertension.
Topics: Adolescent; Adrenergic beta-Antagonists; Anesthesia, General; Child; Coronary Disease; Diuretics; Dr | 1977 |
Prazosin in hypertension. Part I. Clinical experience in 100 patients.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Female; Humans | 1977 |
[A clinical study with prazosin].
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Benzothiadiazines; Depression; Diuretics; Drug Therapy, C | 1978 |
Prazosin in the treatment of uncontrolled hypertension.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Humans; Hypert | 1978 |
Hydrallazine and prazosin.
Topics: Adrenergic beta-Antagonists; Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Prazosin; | 1978 |
[Treatment of arterial hypertension in the aged].
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Antihypertensive Agents; Clonidine; Diuretics; Human | 1978 |
Drug of first choice in mild and moderate essential hypertension--clinical, hemodynamic and economic aspects.
Topics: Adrenergic beta-Antagonists; Benzothiadiazines; Costs and Cost Analysis; Diuretics; Hemodynamics; Hu | 1979 |
Approach to drug therapy for hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diu | 1979 |
Influence of prazosin on the development of antinuclear antibodies in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Antibodies, Antinuclear; Female; Humans; Hype | 1979 |
[Prazosin in the combined treatment of moderate to severe hypertension].
Topics: Adrenergic beta-Antagonists; Body Weight; Diuretics; Dizziness; Drug Therapy, Combination; Female; H | 1979 |
Alpha- and beta-receptor blocking drugs in the treatment of hypertension.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Humans; Hypertension; Labetalol; Prazosin | 1979 |
Changes in glomerular filtration rate during long term treatment with propranolol and peripheral vasodilators in patients with arterial hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Female; Glomerular Filtration Rate; Humans; Hydralazine; Hyperte | 1979 |
[Hypotensive drugs].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Clonidine; Diuretics; Guanidines; Humans; Hype | 1979 |
Orthostatic hypotension due to prazosin.
Topics: Humans; Hypertension; Hypotension, Orthostatic; Prazosin; Quinazolines | 1977 |
[Treatment of arterial hypertension with prazosin. Long term care].
Topics: Humans; Hypertension; Long-Term Care; Prazosin; Quinazolines | 1979 |
Vascular responsiveness to norepinephrine, serotonin, and potassium chloride in veins from spontaneously hypertensive and age-matched Wistar Kyoto rats.
Topics: Animals; Aorta; Hypertension; In Vitro Techniques; Isoproterenol; Jugular Veins; Male; Nitroglycerin | 1979 |
Comment I: some aspects of the pharmacology of prazosin and their clinical implications.
Topics: Animals; Hindlimb; Hypertension; Phosphodiesterase Inhibitors; Prazosin; Quinazolines; Rats; Recepto | 1977 |
Effects of prazosin on cyclic nucleotide content and blood pressure of the spontaneously hypertensive rat.
Topics: Animals; Aorta; Blood Pressure; Cyclic AMP; Cyclic GMP; Hypertension; In Vitro Techniques; Muscle, S | 1979 |
Unimpaired beta adrenergic responses during prazosin administration.
Topics: Blood Glucose; Blood Pressure; Dopamine beta-Hydroxylase; Heart Rate; Humans; Hydralazine; Hypertens | 1979 |
[Effects of prazosin on the alpha-adrenergic receptors and on the nervous reflex arc in essential hypertension].
Topics: Humans; Hypertension; Neural Pathways; Prazosin; Quinazolines; Receptors, Adrenergic; Receptors, Adr | 1978 |
[Drug information: antihypertensive agents. Prazosin (Peripress)].
Topics: Humans; Hypertension; Prazosin; Quinazolines | 1977 |
Hypotensive agents. Part I: Vasodilators.
Topics: Diazoxide; Humans; Hydralazine; Hypertension; Prazosin; Quinazolines | 1979 |
Effect of prazosin on blood pressure and plasma renin activity in man.
Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Prazosin; Quinazolines; Renin | 1978 |
Clinical pharmacology of vasodilators.
Topics: Hemodynamics; Humans; Hypertension; Kidney; Minoxidil; Prazosin; Pyrimidines; Quinazolines; Vasodila | 1979 |
Treatment of hypertension with prazosin. An open study in general practice.
Topics: Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines | 1979 |
Positive antinuclear factor tests with prazosin.
Topics: Aged; Antibodies, Antinuclear; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolin | 1979 |
Does prazosin induce formation of antinuclear factor?
Topics: Antibodies, Antinuclear; Humans; Hypertension; Prazosin; Quinazolines | 1979 |
Does prazosin induce formation of antinuclear factor?
Topics: Antibodies, Antinuclear; Humans; Hypertension; Prazosin; Quinazolines | 1979 |
Antinuclear factor in patients on prazosin.
Topics: Adult; Age Factors; Aged; Antibodies, Antinuclear; Female; Humans; Hypertension; Male; Middle Aged; | 1979 |
Central and renal circulation, renin and aldosterone in plasma during prazosin treatment in essential hypertension.
Topics: Adult; Aged; Aldosterone; Blood Chemical Analysis; Blood Circulation; Cardiac Output; Female; Hemody | 1979 |
Prazosin in practice.
Topics: Adult; Family Practice; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines | 1979 |
Propranolol and newer antihypertensive drugs in the management of hypertension.
Topics: Angiotensin II; Clonidine; Diuretics; Humans; Hypertension; Minoxidil; Prazosin; Propranolol; Sarala | 1979 |
Hypotensive action of prazosin.
Topics: Blood Pressure; Humans; Hypertension; Posture; Prazosin; Quinazolines | 1979 |
Comparative first dose effects of prazosin and tiodazosin (BL-5111) in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Male; Prazosin; Quinazolines; Rats; | 1979 |
Guidelines for evaluating and treating hypertension.
Topics: Aged; Antihypertensive Agents; Benzothiadiazines; Diuretics; Drug Therapy, Combination; Guanethidine | 1979 |
[Experience with prazosin in the treatment of hypertension].
Topics: Humans; Hypertension; Prazosin; Quinazolines | 1979 |
When to use oral vasodilators for hypertension.
Topics: Administration, Oral; Diazoxide; Humans; Hydralazine; Hypertension; Minoxidil; Prazosin; Vasodilator | 1979 |
Exacerbation of angina pectoris by prazosin.
Topics: Acute Disease; Aged; Angina Pectoris; Blood Pressure; Heart Failure; Humans; Hypertension; Male; Pra | 1979 |
[Minipress (Prazosin)].
Topics: Drug Tolerance; Humans; Hypertension; Prazosin; Quinazolines | 1979 |
Effects of prazosin on plasma renin activity and blood pressure.
Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Placebos; | 1979 |
Prazosin and methyldopa in essential hypertension.
Topics: Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Quinazolines | 1979 |
Responsiveness to prazosin in renal failure.
Topics: Adult; Aged; Blood Pressure; Humans; Hypertension; Kidney Failure, Chronic; Middle Aged; Posture; Pr | 1979 |
Open clinical evaluation of prazosin in hypertensive Nigerians.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; | 1979 |
[Short-term and median-term effects of tienilic acid in hypertension].
Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female; Glycolates; Humans; Hypertension; M | 1979 |
[Preliminary evaluation of the use of an antihypertensive drug (prazosin hydrochloride)].
Topics: Aged; Blood Pressure; Drug Evaluation; Drug Tolerance; Female; Humans; Hypertension; Male; Middle Ag | 1979 |
Haemodynamic long-term effects of prazosin plus tolamolol in essential hypertension.
Topics: Adult; Blood Pressure; Cardiac Output; Drug Therapy, Combination; Heart Rate; Hemodynamics; Humans; | 1977 |
Prazosin combined with thiazide diuretic and beta-blocker in the treatment of hypertension.
Topics: Blood Pressure; Cyclopenthiazide; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Pindol | 1977 |
An open evaluation of the efficacy and toleration of prazosin in patients with hypertension.
Topics: Adult; Aged; Drug Evaluation; Drug Tolerance; Female; Humans; Hypertension; Male; Middle Aged; Prazo | 1977 |
[Prazosin as an alternative in the treatment of acute hypertension].
Topics: Adult; Aged; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hyperten | 1977 |
Clinical evaluation of prazosin in essential hypertension.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazoline | 1977 |
[Renal circulation after prazosin administration. Preliminary report].
Topics: Adult; Female; Glomerular Filtration Rate; Humans; Hypertension; Iodohippuric Acid; Kidney; Male; Mi | 1978 |
[Treatment of hypertension with prezosin in aged diabetics].
Topics: Aged; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diet Therapy; Female; Humans; Hypert | 1978 |
[The antihypertensive therapy with prazosin in practice. Results of a multicenter study].
Topics: Drug Evaluation; Humans; Hypertension; Prazosin; Quinazolines | 1978 |
[The results of the essential hypertension treatment with prazosin ("Minipress") (author's transl)].
Topics: Adult; Blood Pressure; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Q | 1978 |
[Refractory hypertension. Pathogenesis and therapy].
Topics: Drug Evaluation; Humans; Hypertension; Prazosin; Renin | 1978 |
Changes in plasma volume and extracellular fluid volume after addition of prazosin to propranolol treatment in patients with hypertension.
Topics: Adult; Blood Pressure; Drug Therapy, Combination; Extracellular Space; Female; Humans; Hypertension; | 1978 |
Prazosin in the diagnosis and treatment of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Blood Pressure; Humans; Hypertension; Male; Norepinephrine; Pheochro | 1978 |
Workup and treatment of the average hypertensive patient.
Topics: Benzothiadiazines; Clonidine; Diuretics; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa | 1978 |
[Clinical evaluation of a quinazoline-derivative hypotensive agent (prazosin or Minipress)].
Topics: Administration, Oral; Adult; Aged; Blood Pressure; Drug Evaluation; Heart Rate; Humans; Hypertension | 1977 |
[Hemodynamic changes induced with prazosin in basic conditions and during some pressor tests in essential hypertension].
Topics: Cold Temperature; Exercise Test; Hemodynamics; Humans; Hypertension; Isometric Contraction; Prazosin | 1978 |
[Peripheral vasodilators in the treatment of hypertension. A review].
Topics: Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Prazosin; Quinazolines | 1979 |
Variability in effect of low doses of prozosin in hypertensive Nigerians.
Topics: Adult; Aged; Blood Pressure; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combin | 1976 |
Prazosin (Minipress) for hypertension.
Topics: Humans; Hypertension; Hypotension, Orthostatic; Prazosin; Quinazolines | 1977 |
Physiologic evaluation of a new antihypertensive agent: prazosin HCl.
Topics: Adult; Blood Pressure; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; | 1977 |
[Prazosin in the treatment of hypertension].
Topics: Adult; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines | 1977 |
[Peripress (prazosin)--a new drug for hypertension].
Topics: Drug Evaluation; Humans; Hypertension; Prazosin; Quinazolines | 1977 |
Prazosin alone and combined with a thiazide diuretic in the treatment of hypertension.
Topics: Adult; Aged; Cyclopenthiazide; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertension; M | 1977 |
Treatment of chronic essential hypertension.
Topics: Chlorothiazide; Clonidine; Diabetes Mellitus; Diet, Sodium-Restricted; Gout; Guanethidine; Humans; H | 1977 |
[Hypotensive action of Minipress: an evaluation].
Topics: Adult; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines | 1977 |
Unanswered questions about prazosin hydrochloride.
Topics: Drug Evaluation; Humans; Hypertension; Prazosin; Quinazolines | 1977 |
Initial experience with prazosin in New Zealand. A multicentre report. New Zealand Hypertension Study Group.
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Pulse; Quinazoline | 1977 |
Open studies with prazosin in the treatment of essential hypertension. Prazosin Research Group in Japan.
Topics: Adult; Aged; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines | 1977 |
Prazosin in severe in hypertension effect on blood pressure, plasma renin activity and in hypertensive emergencies.
Topics: Adult; Animals; Blood Pressure; Depression, Chemical; Dogs; Emergencies; Female; Humans; Hypertensio | 1977 |
Prazosin: its usefulness in hypertension.
Topics: Administration, Oral; Cardiovascular System; Diuretics; Drug Therapy, Combination; Humans; Hypertens | 1977 |
[Prazosin--a new hypotensive agent].
Topics: Adult; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines; Vascular Resistance | 1977 |
[Orthostatic collapse due to prazosin].
Topics: Adult; Female; Humans; Hypertension; Hypotension, Orthostatic; Male; Middle Aged; Prazosin; Quinazol | 1977 |
Prazosin.
Topics: Humans; Hypertension; Prazosin; Quinazolines | 1976 |
A study of the use of prazosin in hypertensive patients in Korea.
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Humans; Hypertension; Korea; Male; Middl | 1976 |
Prazosin in the treatment of patients with hypertension and renal functional impairment.
Topics: Female; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Prazosin; Quinazolines | 1976 |
A study of the interaction between the hypotensive actions of doxazosin and enalaprilat in anaesthetized rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Desoxycorticosterone; Disease Models, Animal; Dose-Res | 1992 |
Central alpha 2-adrenoceptor-mediated pressor response to clonidine in conscious, spontaneously hypertensive rats.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Furosemide; Heart | 1992 |
[Hemorheologic changes in patients with essential hypertension treated with prazosin].
Topics: Adolescent; Adult; Blood Viscosity; Hematocrit; Humans; Hypertension; Middle Aged; Platelet Aggregat | 1992 |
Reduction of left ventricular hypertrophy after longterm antihypertensive treatment with doxazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Aldosterone; Antihypertensive Agents; Blood Pressure; Cardiomeg | 1992 |
Effect of alpha 1-adrenoceptor blockade on the development of hypertension in the spontaneously hypertensive rat.
Topics: Adrenergic alpha-Antagonists; Animals; Biomarkers; Blood Pressure; Body Weight; Hemodynamics; Hypert | 1992 |
Combined effect of doxazosin and pindolol on blood pressure control and lipid concentrations in patients with essential hypertension selected from general practice. Hunter Hypertension Research Group.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Doxazosin; Drug Administration Schedule; | 1992 |
Orthostatic hypotension occurs following alpha 2-adrenoceptor blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dose-Response Rela | 1992 |
Compliance and reactivity of the peripheral venous system in chronic intermittent hemodialysis.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Blood Pressure; Compliance; Doxazosin; Female; Humans; Hy | 1992 |
Participation of arginine vasopressin-mediated and adrenergic system-mediated mechanisms in the hypertension induced by intracerebroventricular administration of NMDA in freely moving rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine Vasopressin; Blood Pressure; Cerebral Ventricles; Clo | 1992 |
Haemodynamic effects of dicentrine, a novel alpha 1-adrenoceptor antagonist: comparison with prazosin in spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Topics: Adrenergic alpha-Antagonists; Animals; Aporphines; Hemodynamics; Hypertension; Injections, Intraveno | 1992 |
Effects of alpha 1-receptor blockade on the hemodynamic responses to exercise in young hypertensives.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Human | 1992 |
Renal hemodynamics in canine DOCA-salt hypertension: effect of calcium channel blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Calcium Channel Blockers; Desoxycorticosteron | 1992 |
The interaction between noradrenaline and ATP upon polyphosphoinositide metabolism and contraction in tail arteries from normo- and hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Dose-Response Relationship, Drug; Drug In | 1992 |
Expression of renal alpha 1-adrenergic receptor subtypes in established hypertension.
Topics: Animals; Dihydropyridines; Hypertension; In Vitro Techniques; Kidney; Kidney Medulla; Male; Membrane | 1992 |
Combination of nifedipine and doxazosin in essential hypertension.
Topics: Aged; Analysis of Variance; Angiotensin II; Antihypertensive Agents; Blood Pressure; Doxazosin; Drug | 1992 |
Enalapril reduces the enhanced 1,2-diacylglycerol content and RNA synthesis in spontaneously hypertensive rat hearts before established hypertension.
Topics: Animals; Body Weight; Cardiomegaly; Diglycerides; Enalapril; Heart Ventricles; Hypertension; Lipids; | 1992 |
Doxazosin: alternative antihypertensive treatment.
Topics: Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Type 2; Doxazosin; Female; Humans; Hyper | 1992 |
[Effect of long-term treatment with prazosin and its combination with nadolol on the levels of blood hormones of the hypophyseal- gonadal system in patients with hypertension].
Topics: Adult; Drug Therapy, Combination; Estradiol; Humans; Hyperprolactinemia; Hypertension; Male; Middle | 1992 |
[Long-term treatment of hypertensive patients with captopril, enalapril and prazosin].
Topics: Adult; Captopril; Enalapril; Female; Heart; Hemodynamics; Humans; Hypertension; Male; Middle Aged; P | 1992 |
[The optimization of the hypotensive therapy of hypertension patients taking into account the central hemodynamics and functional tests with obzidan and prazosin].
Topics: Adult; Antihypertensive Agents; Exercise Test; Female; Hemodynamics; Humans; Hypertension; Male; Mid | 1992 |
Management of the cardiovascular manifestations of poisoning by the Indian red scorpion (Mesobuthus tamulus).
Topics: Adult; Aged; Animals; Cardiovascular Diseases; Child; Child, Preschool; Drug Therapy, Combination; F | 1992 |
Use of Tensiomin in hypertensive patients with impaired renal function.
Topics: Adult; Captopril; Creatinine; Humans; Hydralazine; Hypertension; Kidney; Kidney Failure, Chronic; Mi | 1992 |
Effect of age and dose on the incidence of adverse events in the treatment of hypertension in patients receiving terazosin.
Topics: Adolescent; Adult; Age Factors; Aged; Dose-Response Relationship, Drug; Humans; Hypertension; Middle | 1992 |
[Adrenal gland pheochromocytomas. Apropos of 35 operated patients].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Child; Female; Humans; Hypertension; Intraoperativ | 1992 |
Blood pressure control in arterial- and cardiopulmonary receptor denervated dogs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arteries; Blood Pressure; Denervation; Dogs; Fema | 1991 |
Arterial neuroeffector responses in early and mature spontaneously hypertensive rats.
Topics: Animals; Arteries; Cocaine; Electric Stimulation; Hypertension; Male; Neuroeffector Junction; Prazos | 1991 |
New alpha 1-adrenergic blocker offers once-daily dosing.
Topics: Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Doxazosin; Humans; Hypertension; Prazos | 1991 |
Management of coronary heart disease risk factors in hypertensive patients: clinical experience with doxazosin. A symposium. London, England, January 26, 1990. Proceedings.
Topics: Antihypertensive Agents; Coronary Disease; Doxazosin; Humans; Hypertension; Prazosin; Risk Factors | 1991 |
Effect of alpha-adrenergic blockade on blood pressure, glucose, and lipid metabolism in hypertensive patients with non-insulin-dependent diabetes mellitus.
Topics: Adrenergic alpha-Antagonists; Aged; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Drug E | 1991 |
Quipazine-induced hypertension in anaesthetized cats is mediated by central and peripheral 5-HT2 receptors: role of the ventrolateral pressor area.
Topics: Animals; Blood Pressure; Cats; Cyproheptadine; Female; Heart Rate; Hexamethonium; Hexamethonium Comp | 1991 |
Clinical model for antihypertensive therapy in the 1990s: the role of alpha1 blockade. Proceedings of a symposium. Irving, Texas, November 8-10, 1990.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Prazosin | 1991 |
Acute hemodynamic effects of terazosin in hypertensive and normotensive patients.
Topics: Adrenergic alpha-Antagonists; Cardiac Catheterization; Dose-Response Relationship, Drug; Drug Evalua | 1991 |
Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Desoxycorticosterone; Heart Rat | 1990 |
First-choice antihypertensive drug use in the Glasgow Blood Pressure Clinic.
Topics: Adrenergic beta-Antagonists; Ambulatory Care Facilities; Angiotensin-Converting Enzyme Inhibitors; A | 1990 |
Modification of circadian blood pressure and heart rate variability by five different antihypertensive agents in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Heart Rate | 1991 |
Effects of long-term treatment with prazosin on left ventricular diastolic function in mild to moderate hypertension.
Topics: Adult; Blood Pressure; Diastole; Echocardiography; Female; Humans; Hypertension; Male; Prazosin; Rad | 1992 |
Priapism in haemodialysis patient due to prazosin?
Topics: Adult; Drug Therapy, Combination; Heparin; Humans; Hypertension; Male; Methyldopa; Nifedipine; Prazo | 1991 |
[Long-term prazosin treatment of arterial hypertension in ambulatory care].
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Outpatients | 1991 |
[A study on blood pressure variation--the clinical validation of continuous direct blood pressure recording in patients with pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Blood Pressure; Blood Pressure Monitors; Catecholamines; Humans; Hypertensi | 1991 |
Differences in inositol phosphate production in blood vessels of normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Vessels; Hydrolysis; Hypertension; In Vitro Techniques; Inositol Phosphates; Norepine | 1991 |
[The effect of prazosin and korinfar on the central hemodynamics and liver blood flow in hypertension patients (based on 2-dimensional Doppler echography)].
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hemodynamics; Humans; | 1991 |
A case of extraadrenal pheochromocytoma with papillary thyroid carcinoma.
Topics: Abdominal Neoplasms; Carcinoma, Papillary; Catecholamines; Female; Humans; Hypertension; Magnetic Re | 1991 |
Prazosin in chronic congestive heart failure due to ischemic heart disease.
Topics: Aged; Blood Pressure; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Female; Follow-Up | 1991 |
Prazosin's effect in high renin hypertension complicating pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Female; Humans; Hypertension; Middle Aged; Pheochromocytoma; Prazosin; Reni | 1991 |
Assessing the effects of antihypertensive medication on cerebral blood flow: demonstration in internal carotid artery occlusion.
Topics: Aged; Arterial Occlusive Diseases; Carotid Artery Diseases; Carotid Artery, Internal; Cerebrovascula | 1991 |
The effect of doxazosin on platelet aggregation in normotensive subjects and patients with hypertension: an in vitro study.
Topics: Adult; Antihypertensive Agents; Blood Platelets; Dose-Response Relationship, Drug; Doxazosin; Female | 1991 |
Doxazosin for treatment of hypertension.
Topics: Antihypertensive Agents; Blood Glucose; Doxazosin; Humans; Hypertension; Lipids; Prazosin | 1991 |
Diabetes mellitus and hypertension: a physiologic basis for a rational therapeutic approach.
Topics: Antihypertensive Agents; Biological Transport; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; | 1991 |
[The effect of doxazosin on blood pressure, lipids, fibrinogen and plasminogen activator inhibitor. A comparative study among smokers and non-smokers with essential hypertension].
Topics: Adult; Blood Pressure; Doxazosin; Fibrinogen; Humans; Hypertension; Lipids; Middle Aged; Plasminogen | 1991 |
Prolonged photostress macular recovery after reduced blood pressure.
Topics: Adaptation, Physiological; Adult; Aerospace Medicine; Antihypertensive Agents; Blood Pressure; Doxaz | 1991 |
Peripheral alpha-1 and alpha-2 adrenergic receptors in three models of hypertension in rats: an in vitro autoradiography study.
Topics: Adrenal Glands; Animals; Autoradiography; Blood Pressure; Blood Vessels; Desoxycorticosterone; Hyper | 1991 |
Alterations in cardiovascular responsiveness and adrenoceptor binding during catecholamine infusion hypertension in rats.
Topics: Angiotensin II; Animals; Aorta; Arginine Vasopressin; Blood Pressure; Hypertension; Infusions, Paren | 1991 |
[Brain adrenoreceptors in rats with inherited arterial hypertension due to emotional stress].
Topics: Animals; Brain; Clonidine; Dihydroalprenolol; Hypertension; Prazosin; Radioligand Assay; Rats; Rats, | 1991 |
Exaggerated sympathetic nervous system response to extended psychological stress in offspring of hypertensives.
Topics: Adult; Blood Pressure; Blood Volume; Forearm; Heart Rate; Humans; Hypertension; Male; Metoprolol; Mi | 1991 |
Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs.
Topics: Animals; Blood Pressure; Body Weight; Cardiac Output; Dexamethasone; Dogs; Heart Rate; Hemodynamics; | 1991 |
The cost-benefit approach to pricing new medicines: doxazosin versus beta-blocker treatment in Sweden.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Atenolol; Blood Pressure; Cholesterol; Cost-B | 1990 |
Efficacy of terazosin in the treatment of essential hypertension in blacks.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Black People; Female; Humans; Hypertension; M | 1990 |
Effects of terazosin on serum lipid levels in hypertensive blacks.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Black People; Female; Humans; Hypertension; L | 1990 |
Reversal of left ventricular hypertrophy by terazosin in hypertensive patients.
Topics: Adrenergic alpha-Antagonists; Aged; Cardiomegaly; Drug Evaluation; Electrocardiography; Female; Hear | 1990 |
[Therapeutic drug monitoring of alpha-blocker, prazosin].
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Biological Availability; Chromatography, High | 1990 |
The alpha-adrenoceptor mediating the tubular actions of the renal nerves in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Dioxanes; Glomerular Filtration Rate; Hyperte | 1990 |
Hypertension, coronary risk and alpha-blockade.
Topics: Adrenergic alpha-Antagonists; Coronary Disease; Doxazosin; Humans; Hypertension; Prazosin; Risk Fact | 1990 |
Alpha 1-adrenoreceptor blockade and the molecular basis of lipid metabolism alterations.
Topics: Adrenergic alpha-Antagonists; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Dox | 1990 |
Selective alpha 1 inhibition with doxazosin in hypertensive smokers and non-smokers: haemodynamic and metabolic effects.
Topics: Adrenergic alpha-Antagonists; Adult; Doxazosin; Female; Fibrinogen; Hemodynamics; Humans; Hypertensi | 1990 |
[Effects of terazocin on hypertensive patients].
Topics: Adrenergic alpha-Antagonists; Adult; Female; Humans; Hypertension; Male; Middle Aged; Prazosin | 1990 |
[Alpha-1 inhibition and blood pressure regulation].
Topics: Adrenergic alpha-Antagonists; Blood Pressure; Humans; Hypertension; Prazosin | 1990 |
Effects of the angiotensin I converting enzyme inhibitor perindopril on cerebral blood flow in awake hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cerebrovascular Circulation; Hemodynam | 1991 |
Vasopressin and autonomic mechanisms mediate cardiovascular actions of central serotonin.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Chlorisondamine; Ergolines; Heart Ra | 1991 |
Effect of prazosin treatment on HDL kinetics in patients with hypertension.
Topics: Apolipoprotein A-I; Apolipoproteins A; Blood Pressure; Cholesterol, HDL; Drug Administration Schedul | 1990 |
The pharmacokinetics of doxazosin in patients with hypertension and renal impairment.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Doxazosin; F | 1990 |
[Doxazosin--therapeutic advantages in hypertension].
Topics: Doxazosin; Humans; Hypertension; Prazosin | 1990 |
Beta-thromboglobulin and platelet aggregation in essential hypertension and the influence of prazosin therapy.
Topics: Adult; beta-Thromboglobulin; Female; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; | 1990 |
The effect of prazosin therapy on platelet activation in essential hypertension.
Topics: Adolescent; Adult; beta-Thromboglobulin; Blood Pressure; Female; Humans; Hypertension; Male; Middle | 1990 |
[Doxazosin for the treatment of arterial hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Dose-Response Relationship, Drug; Doxazosin; Drug Administrati | 1990 |
Developing renal innervation in the spontaneously hypertensive rat: evidence for a role of the sympathetic nervous system in renal damage.
Topics: Animals; Female; Guanethidine; Hypertension; Kidney; Male; Prazosin; Rats; Rats, Inbred SHR; Rats, I | 1990 |
Enhanced phosphoinositide hydrolysis in the pineal gland of spontaneously hypertensive rats.
Topics: Animals; Carbachol; Hydrolysis; Hypertension; Male; Norepinephrine; Phosphatidylinositols; Pineal Gl | 1990 |
Use of tensiomin (captopril) in the antihypertensive treatment of haemodialysis patients.
Topics: Adult; Antihypertensive Agents; Captopril; Drug Therapy, Combination; Female; Guanfacine; Guanidines | 1990 |
[Cardiovascular reactivity to isometric stress in patients with stable and borderline hypertension and in normotensive subjects. Effects of alpha sympatholytics and beta blocking agents].
Topics: Adult; Blood Pressure; Exercise; Heart Rate; Humans; Hypertension; Male; Middle Aged; Prazosin; Prop | 1990 |
[Use of prazosin in the treatment of patients with hypertension].
Topics: Adult; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Prazosin; Time Factors | 1990 |
In vitro caffeine induced aortic smooth muscle reactivity in rat.
Topics: Animals; Aorta; Caffeine; Hypertension; In Vitro Techniques; Magnesium; Male; Muscle, Smooth, Vascul | 1990 |
Nicardipine in combination with other antihypertensive drugs: calcium antagonist and prazosin have no additive antihypertensive effect?
Topics: Adult; Aged; Calcium Channel Blockers; Drug Interactions; Drug Therapy, Combination; Female; Humans; | 1990 |
[The anti-lipidemic effect of Minipress].
Topics: Coronary Disease; Drug Evaluation; Humans; Hypercholesterolemia; Hyperlipidemias; Hypertension; Hypo | 1990 |
Antihypertensive effects of ketanserin in the spontaneously hypertensive rat: mode of action.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Piperi | 1985 |
Serotonergic mechanisms and blood pressure in sheep.
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Blood Pressure; Female; Heart Ra | 1985 |
Excitation-contraction coupling in hypertrophied myocardium.
Topics: Age Factors; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Epinephrine; Heart; Hypertension | 1985 |
The clinical pharmacology of indoramin.
Topics: Blood Pressure; Heart Rate; Humans; Hypertension; Indoles; Indoramin; Kinetics; Norepinephrine; Phen | 1986 |
Antihypertensive effects and pharmacokinetics of single and consecutive administration of doxazosin in patients with mild to moderate essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Catecholamines; Creatinine; Doxazosin; Electrolytes; Female; Hea | 1987 |
Increased 45Ca influx in response to alpha 1-adrenoceptor stimulation in spontaneously hypertensive rat caudal artery.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Blood Pressure; Calcium; Hypertension; In | 1987 |
Effects of doxazosin on vascular collagen synthesis, arterial pressure and serum lipids in the spontaneously hypertensive rat.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Collagen; Dose-Response Relationship, Drug; D | 1987 |
Substance P in human essential hypertension.
Topics: Adult; Blood Pressure; Captopril; Humans; Hypertension; Norepinephrine; Prazosin; Stress, Psychologi | 1987 |
Antihypertensive effects of ketanserin and ritanserin in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Phenyl | 1988 |
Antagonism of alpha 1-adrenoceptor-mediated vascular contraction by urapidil in isolated arterial strips of spontaneously hypertensive rats.
Topics: Age Factors; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Hypertension; In Vi | 1988 |
Decreased density of alpha 2-adrenoceptors in medulla oblongata of spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Clonidine; Hypertension; Medulla Oblongata; Norepinephrine; Phentolamine; Pr | 1989 |
Regression of cardiac hypertrophy: experimental and clinical results.
Topics: Animals; Cardiomegaly; Clonidine; Enalapril; Humans; Hypertension; Nifedipine; Prazosin; Rats; Rats, | 1987 |
Left ventricular hypertrophy in hypertensive patients.
Topics: Cardiomegaly; Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Prazosin | 1989 |
Regression of left ventricular hypertrophy in hypertension. Effects of prazosin therapy.
Topics: Blood Pressure; Cardiomegaly; Echocardiography; Female; Heart; Humans; Hypertension; Male; Middle Ag | 1989 |
Single-dose and steady-state pharmacokinetics of doxazosin given in combination with chlorothiazide to hypertensive subjects.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Chlorothiazide; Doxazosin; Female; Half-Life; | 1989 |
An investigation of the effects of intravenous injection of the 5-hydroxytryptamine 2 receptor antagonists ketanserin and LY 53857 on blood pressure in anesthetized spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Ergolines; Heart Rate; | 1989 |
Renal alpha-adrenoceptor density and blood pressure in SHR rats exposed chronically to prazosin and/or yohimbine.
Topics: Animals; Blood Pressure; Hypertension; Kidney; Male; Prazosin; Radioligand Assay; Rats; Rats, Inbred | 1989 |
Increases in vascular alpha 1-adrenoceptor affinity and PI turnover in DOCA-salt hypertensive rats.
Topics: Animals; Biotransformation; Desoxycorticosterone; Hypertension; Lithium; Male; Muscle, Smooth, Vascu | 1989 |
Alpha-adrenoceptor properties in rat strains sensitive or resistant to salt-induced hypertension.
Topics: Animals; Cerebral Cortex; Hypertension; Kidney Cortex; Kinetics; Male; Norepinephrine; Prazosin; Rat | 1989 |
Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Dose-Response Relationship, Drug; Hand; Humans; Hypertens | 1989 |
Alpha-blockade for hypertension: indifferent past, uncertain future.
Topics: Antihypertensive Agents; Coronary Disease; Doxazosin; Drug Evaluation; Humans; Hypertension; Prazosi | 1989 |
Clinical settings for selective alpha-adrenergic receptor inhibition: rationale and management strategies. Proceedings of a symposium. Naples, Florida, October 13 to 16, 1988.
Topics: Adrenergic alpha-Antagonists; Antihypertensive Agents; Doxazosin; Humans; Hypertension; Prazosin | 1989 |
Alpha-blockade on blood pressure and on cardiac noradrenaline content in SHR and DOCA-salt rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Body Weight; Desoxycorticosterone; Heart; Hyp | 1989 |
Predictability of antihypertensive responsiveness and alpha-adrenoceptor antagonism during prazosin treatment.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Analysis of Variance; Blood Pressure; Female; Heart Rate; | 1989 |
Hemodynamic and endocrinological effects of a new selective alpha 1-blocking agent, terazosin, in patients with essential hypertension. Results of long-term treatment.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Female; Hemodynamics; Humans; Hypertension; Male; Middle | 1989 |
[Clinical application of adrenoceptor blockers in the treatment of hypertension].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Humans; Hypertens | 1989 |
Doxazosin, a new alpha-1-antagonist drug, controls hypertension without causing airways obstruction in asthma and COPD.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Asthma; Blood Pressure; Doxazosin; Female; Forced Expirat | 1989 |
Plethysmographic effects of doxazosin in essential hypertensive patients.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Doxazosin; Drug | 1989 |
[Prazosin in the treatment of arterial hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hy | 1989 |
Centrally acting alpha-2 agonists, peripherally acting adrenergic-blocking drugs, and direct vasodilators in the treatment of mild and moderate essential hypertension.
Topics: Adult; Aged; Black People; Clinical Protocols; Clonidine; Drug Therapy, Combination; Humans; Hydrala | 1989 |
[Efficacy, tolerance and incidence of risk factors of Alpress in the treatment of arterial hypertension].
Topics: Adult; Aged; Coronary Disease; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Hyperte | 1989 |
Effect of prazosin treatment on carbohydrate and lipoprotein metabolism in patients with hypertension.
Topics: Adult; Blood Glucose; Dietary Carbohydrates; Fatty Acids, Nonesterified; Female; Humans; Hypertensio | 1989 |
Therapy of venous hypertension in calves with total artificial heart (TAH).
Topics: Animals; Antihypertensive Agents; Captopril; Cardiac Pacing, Artificial; Cattle; Central Venous Pres | 1989 |
Decreased rectal body temperature induced by different vasodilatory drugs.
Topics: Adult; Epoprostenol; Female; Humans; Hypertension; Hypothermia; Middle Aged; Nifedipine; Prazosin; R | 1989 |
Cyclosporine-associated hypertension in cardiopulmonary transplantation. The beneficial effect of nifedipine on renal function.
Topics: Adult; Cyclosporins; Heart Transplantation; Humans; Hypertension; Kidney; Lipids; Lung Transplantati | 1989 |
Exacerbation of human cataplexy by prazosin.
Topics: Cataplexy; Female; Hallucinations; Humans; Hypertension; Middle Aged; Prazosin; Sleep Stages | 1989 |
Adrenergic blocking agents and lipoprotein lipase activity.
Topics: Adult; Blood Pressure; Cholesterol; Cholesterol, HDL; Enzyme Activation; Female; Heart Rate; Humans; | 1989 |
[Experience in using minipress in essential hypertension].
Topics: Adult; Aged; Erythrocyte Aggregation; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; | 1989 |
Selective modification of renal alpha 2-adrenergic receptors in Milan hypertensive rat strain.
Topics: Age Factors; Animals; Brain; Hypertension; Kidney Cortex; Male; Norepinephrine; Prazosin; Rats; Rats | 1987 |
Hypertensinogenic factors and renal alpha-adrenoceptors in young SHR and WKY rats.
Topics: Animals; Blood Pressure; Body Weight; Desoxycorticosterone; Hypertension; Kidney; Male; Prazosin; Ra | 1987 |
Differential ontogeny of alpha 1-adrenergic and cholinergic receptor sites in the atria and ventricles of the inbred Dahl hypertension-sensitive (S/JR) and -resistant (R/JR) rat.
Topics: Animals; Binding Sites; Female; Heart; Heart Atria; Heart Ventricles; Hypertension; Male; Myocardium | 1987 |
Mechanism of action of ketanserin in hypertension and vasospastic disease.
Topics: Blood Pressure; Drug Therapy, Combination; Fingers; Humans; Hypertension; Ketanserin; Muscle, Smooth | 1987 |
Renal alpha 1-adrenergic receptor response coupling in spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Carbachol; Hypertension; Inositol Phosphates; Kidney; Kidney Cortex; Male; | 1988 |
Adrenaline and enhanced vasoconstriction in patients with essential hypertension.
Topics: Epinephrine; Humans; Hypertension; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Vasoconstric | 1988 |
Dietary sodium restriction and blood pressure response to alpha-receptor blockade in young spontaneously hypertensive rats.
Topics: Age Factors; Animals; Blood Pressure; Hypertension; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred S | 1988 |
Alpha-adrenoceptors in Dahl hypertensive and normotensive rats: effect of sodium.
Topics: Animals; Cell Membrane; Cerebral Cortex; Hypertension; Kidney Cortex; Prazosin; Rats; Rats, Mutant S | 1988 |
[Circadian rise of blood pressure and combined alpha-beta adrenoceptor blockade].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Circadian Rhythm; Cold Temperature; Drug | 1985 |
Clinical pharmacology of vasodilator drugs.
Topics: Adrenergic alpha-Antagonists; Calcium Channel Blockers; Coronary Disease; Humans; Hydralazine; Hyper | 1985 |
Differences in response of black hypertensives to alpha vs. beta adrenergic antagonists: preliminary findings.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Black People; Clonidine; Female; Heart Ra | 1985 |
Geriatric hypertension controversies: uses of newer agents.
Topics: Adrenergic beta-Antagonists; Aged; Calcium Channel Blockers; Enzyme Inhibitors; Hemodynamics; Humans | 1985 |
[Hypertension in pregnancy: proposed monitoring and therapy].
Topics: Adrenergic beta-Antagonists; Captopril; Diuretics; Female; Follow-Up Studies; Humans; Hydralazine; H | 1985 |
Current concepts in treatment of hypertensive urgencies.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Co | 1986 |
Acute effect of nifedipine on blood pressure and left ventricular ejection fraction in severely hypertensive outpatients: predictive effects of acute therapy and prolonged efficacy when added to existing therapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Cardiomegaly; Drug Therapy, Combination; F | 1986 |
Altered renal alpha-adrenoceptor regulation in DOCA-salt rats: chronic effects of alpha 1- and alpha 2-receptor blockers.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Blood Pressure; Desoxycorticosterone; Hyperten | 1986 |
Alpha 1-adrenergic blockade and cardiovascular pressor responses in essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Pressure; Cardiovascular System; Drug Interactions; Elect | 1986 |
The pharmacological basis for the use of alpha 1-adrenoceptor antagonists in the treatment of essential hypertension.
Topics: Adrenergic alpha-Antagonists; Benzothiadiazines; Diuretics; Hemodynamics; Humans; Hypertension; Praz | 1986 |
Advances in the management of hypertension: focus on terazosin, a new alpha1-adrenergic antagonist. May 3-5, 1985, Boca Raton, Florida.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Piperazines; Prazosin | 1986 |
Pharmacology of terazosin.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Chemical Phenomena; Che | 1986 |
Pharmacokinetics of terazosin.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Aged; Animals; Blood Proteins; Chemical Phenomen | 1986 |
Long-term experience with terazosin for treatment of mild to moderate hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Dru | 1986 |
Overall safety of terazosin as an antihypertensive agent.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Aged; Asthenia; Body Weight; Dizziness; Female; Hea | 1986 |
Clinical pharmacology and therapeutic role of prazosin and related alpha-adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Age Factors; Animals; Antihypertensive Agents; Blood Pressure; Doxazos | 1986 |
Hypertensive therapy in blacks. Significance of pathophysiologic observations.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Black or African American; Diuretics; | 1986 |
CI-926 (3-[4-[4-(3-methylphenyl)-1-piperazinyl]butyl]-2,4-imidazolinedione): antihypertensive profile and pharmacology.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Dogs; Female; | 1986 |
Role of alpha 1- and alpha 2-adrenergic receptors in the human hypertensive kidney.
Topics: Adrenergic alpha-Antagonists; Adult; Doxazosin; Humans; Hypertension; Kidney; Middle Aged; Prazosin; | 1987 |
Altered intracellular adrenoceptor distribution in myocardium of spontaneously hypertensive rats.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cell Membrane; Cytosol; Dihydroalprenolol; Hyperten | 1987 |
Geriatric hypertension: antihypertensive therapy in coronary artery disease.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blocker | 1987 |
Is there a role for renal alpha 2-adrenoceptors in the pathogenesis of hypertension?
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Gluconeogenesis; Guanfacine; Guanidines; Hypertension | 1987 |
[Chronic effect of prazosin and yohimbine on the renal epinephrine content of DOCA-sodium and SHR-hypertensive rats].
Topics: Adrenergic alpha-Antagonists; Animals; Desoxycorticosterone; Epinephrine; Hypertension; Kidney; Praz | 1987 |
Observations with minipress.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Diuretics; Drug Evaluation; Drug Therapy, | 1986 |
The cardiovascular responses to sequential inhibition of alpha-adrenoceptors, the renin-angiotensin system and vasopressin in rats with adrenal regeneration hypertension.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Circadian Rhyt | 1988 |
Prazosin contraindicated in patients with narcolepsy.
Topics: Aged; Cataplexy; Female; Humans; Hypertension; Male; Middle Aged; Narcolepsy; Prazosin | 1988 |
Doxazosin in the treatment of mild and moderate essential hypertension in general medical practice.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
Clinical experience with doxazosin in general medical practice.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
Control of coronary heart disease risk factors with doxazosin as monotherapy and in combination therapy.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Coronary Disease; Doxazosin; Dru | 1988 |
Doxazosin in the treatment of patients with mild or moderate hypertension and mild or moderate renal insufficiency.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
A single-blind study of doxazosin in the treatment of mild-to-moderate essential hypertensive patients with concomitant noninsulin-dependent diabetes mellitus.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
The addition of doxazosin to the treatment regimen of hypertensive patients not responsive to nifedipine.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Disease | 1988 |
A single-blind study of doxazosin in the treatment of essential hypertension when added to nonresponders to angiotensin-converting enzyme inhibitor therapy.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensiv | 1988 |
First European review of terazosin. Proceedings of a symposium. Reykjavik, Iceland, 29th-31st May 1987.
Topics: Adrenergic alpha-Antagonists; Humans; Hypertension; Prazosin | 1987 |
Analysis of the mechanism underlying the vasodilator action of carvedilol in pithed spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Carbazoles; Carvedilol; Decerebrate State; Dos | 1988 |
Effect of calcium entry blockers on blood pressure and vasoconstrictor responses to alpha-1 adrenoceptor stimulation in conscious spontaneously hypertensive rats.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Binding, Competitive; Blo | 1987 |
Cardiovascular effects of short-term selective alpha 1-adrenergic blockade with terazosin in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; | 1985 |
Effects of prazosin on blood pressure and diabetic control in patients with type II diabetes mellitus and mild essential hypertension.
Topics: Adult; Aged; Blood Pressure; Diabetes Mellitus, Type 2; Female; Glucose; Heart Rate; Humans; Hyperte | 1989 |
Chronic 5-HT2 receptor blockade with ritanserin does not reduce blood pressure in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; | 1985 |
[Progression and regression of heart hypertrophy in arterial hypertension: pathophysiology and clinical aspects].
Topics: Blood Pressure; Cardiac Volume; Cardiomegaly; Cardiomyopathy, Hypertrophic; Clonidine; Coronary Circ | 1985 |
[Several cardiovascular manifestations induced by vibrational stimuli].
Topics: Adult; Autonomic Nervous System Diseases; Cardiovascular Diseases; Fingers; Humans; Hypertension; Me | 1985 |
Alpha 1-adrenoreceptor blockade in hypertension: pharmacological and clinical profile of doxazosin. Proceedings of an international symposium. Venice, Italy, 14 June 1985.
Topics: Animals; Antihypertensive Agents; Doxazosin; Humans; Hypertension; Prazosin | 1986 |
Acute and chronic haemodynamic effects of doxazosin in hypertension at rest and during exercise.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Doxazosin; Female; Hemodynamic | 1986 |
Haemodynamics and the participation of pressor systems in young and adult rats with age-dependent DOCA-salt hypertension.
Topics: Aging; Animals; Blood Pressure; Captopril; Desoxycorticosterone; Hemodynamics; Hypertension; Male; P | 1987 |
A symposium: Doxazosin: coronary artery disease risk factor management. June 7, 1986, Frankfurt, Germany.
Topics: Antihypertensive Agents; Coronary Disease; Doxazosin; Humans; Hypertension; Prazosin; Risk | 1987 |
[Hemodynamic effect of a combination of prazosin with cardiac depressants in the treatment of hypertension].
Topics: Anti-Arrhythmia Agents; Celiprolol; Clonidine; Drug Evaluation; Drug Synergism; Drug Therapy, Combin | 1988 |
Comparison of cicletanine with other antihypertensive drugs in SHR-SP models.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Cardiomegaly; Diuresis; Di | 1988 |
Doxazosin: A distinctive approach to risk reduction of coronary heart disease in hypertensive patients. Proceedings of a symposium. Hamburg, West Germany, January 30, 1988.
Topics: Antihypertensive Agents; Coronary Disease; Doxazosin; Humans; Hypertension; Prazosin; Risk Factors | 1988 |
Antihypertensive profile of cicletanine, a furopyridine derivative: comparison with captopril, indapamide and prazosin.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Captopril; Cardiomegaly; Diuresis; Diuretic | 1988 |
[Circulatory homeostasis in patients with hypertension during acute and chronic blockade of alpha 1-adrenoreceptors].
Topics: Adult; Hemodynamics; Homeostasis; Humans; Hypertension; Male; Middle Aged; Prazosin | 1988 |
Antihypertensive mechanism of action of ketanserin and some ketanserin analogues in the spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Ketan | 1985 |
Effect of sympathetic stimulation and intrarenal alpha-blockade on the secretion of renin by the human kidney.
Topics: Adult; Doxazosin; Female; Hemodynamics; Humans; Hypertension; Isometric Contraction; Kidney; Male; M | 1985 |
Central adrenergic receptor control of renal function in conscious hypertensive rats.
Topics: Animals; Blood Pressure; Clonidine; Guanabenz; Hypertension; Kidney; Male; Natriuresis; Phenoxybenza | 1986 |
Effects of pheochromocytoma on cardiovascular alpha adrenergic receptor system.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Hypertension; In Vitro Techniques; Mesenteric Arteries; My | 1985 |
Vasodepressor effects of prazosin during insulin-induced hypoglycemia in hypertensive patients.
Topics: Adult; Blood Pressure; Cardiac Output; Catecholamines; Echocardiography; Hemodynamics; Humans; Hyper | 1985 |
Ontogeny of renal alpha-1 and alpha-2 adrenoceptors in the spontaneously hypertensive rat.
Topics: Age Factors; Animals; Hypertension; Kidney; Kinetics; Male; Prazosin; Rats; Rats, Inbred SHR; Rats, | 1986 |
Pre- and neonatal exposure of the Dahl rat to NaCl: development and regional distribution of myocardial alpha 1-adrenergic and cholinergic receptor sites.
Topics: Animals; Animals, Newborn; Blood Pressure; Body Weight; Cell Membrane; Female; Heart; Heart Atria; H | 1986 |
The ontogeny of renal alpha 1- and alpha 2-adrenoceptors in the Dahl rat model of experimental hypertension.
Topics: Age Factors; Animals; Female; Hypertension; Kidney; Kinetics; Male; Membranes; Prazosin; Rats; Rats, | 1986 |
Alpha 1-adrenoceptor blockade and altered renal alpha 2-adrenoceptors: a model(?) for the study of genetically altered alpha 2-adrenoceptors in hypertensive rats.
Topics: Animals; Hypertension; Kidney; Male; Natriuresis; Prazosin; Rats; Rats, Inbred Strains; Receptors, A | 1986 |
Alterations of myocardial alpha 1-adrenergic receptors in hypertensive cardiac hypertrophy in the rat.
Topics: Aging; Animals; Blood Pressure; Cardiomegaly; Hypertension; Hypertension, Renal; Male; Myocardium; O | 1986 |
Central alpha-adrenoceptors during the development of hypertension in rats on high and low salt intake.
Topics: Animals; Blood Pressure; Diet, Sodium-Restricted; Hypertension; Hypothalamus; Male; Medulla Oblongat | 1986 |
Characterization of the alpha-1 adrenergic receptors in the thoracic aorta of control and aldosterone hypertensive rats: correlation of radioligand binding with potassium efflux and contraction.
Topics: Aldosterone; Angiotensin II; Animals; Aorta, Thoracic; Dibenzylchlorethamine; Hypertension; Muscle C | 1987 |
Prazosin partly blocks clonidine-induced hypotension in patients with essential hypertension.
Topics: Adult; Blood Pressure; Chlorthalidone; Clonidine; Drug Therapy, Combination; Heart Rate; Humans; Hyp | 1987 |
On the relationship between clonidine hypotension and brain beta-endorphin in the spontaneously hypertensive rat: studies with alpha adrenergic and opiate blockers.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Clonidine; Endorphins; Heart Rate; Hypertension; Hyp | 1987 |
Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension.
Topics: Blood Glucose; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin; Insulin Infusion Syste | 1988 |
[Changes in the hemodynamics and cardiac function of hypertension patients on moderate limited consumption of table salt].
Topics: Adult; Antihypertensive Agents; Captopril; Combined Modality Therapy; Diet, Sodium-Restricted; Femal | 1988 |
Priapism secondary to prazosin therapy.
Topics: Adult; Drug Therapy, Combination; Humans; Hypertension; Male; Prazosin; Priapism | 1987 |
Interference of ketanserin with baroreflex control of the circulation in the conscious spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Heart Rate; Hypertension; Ketanserin; Male; Piperidines; Prazosin; Pressore | 1988 |
[Combined antihypertensive pharmacotherapy].
Topics: Adult; Antihypertensive Agents; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Femal | 1988 |
[Changes in myocardial function in patients with hypertension during treatment with minipress].
Topics: Adult; Aged; Blood Pressure; Female; Heart Ventricles; Humans; Hypertension; Male; Middle Aged; Myoc | 1988 |
[The role of the exercise test in the differentiated treatment of patients with hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Exercise Test; Fe | 1988 |
Diabetes mellitus and hypertension. State of the art lecture.
Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Diabetes Mellitus, Experimental; Diabetes Mellit | 1988 |
Enhanced blood pressure response to isometric handgrip exercise in patients with essential hypertension: effects of propranolol and prazosin.
Topics: Adult; Blood Pressure; Epinephrine; Female; Heart Rate; Humans; Hypertension; Isometric Contraction; | 1987 |
Urinary incontinence secondary to prazosin.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Sex Facto | 1988 |
Lack of relationship between debrisoquine oxidation phenotype and the pharmacokinetics and first dose effect of prazosin.
Topics: Blood Pressure; Debrisoquin; Female; Half-Life; Humans; Hypertension; Isoquinolines; Male; Middle Ag | 1988 |
Pressor mechanisms linked obligatorily to spontaneous hypertension in the rat.
Topics: Animals; Blood Pressure; Electric Stimulation; Female; Hypertension; Male; Methoxamine; Norepinephri | 1988 |
[Effect of prazozin on systemic and regional hemodynamics in hypertension].
Topics: Adult; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Prazosin | 1987 |
System approach to testing hypotensive drugs for prevention of arterial hypertension.
Topics: Clinical Trials as Topic; Humans; Hydralazine; Hyperlipidemias; Hypertension; Prazosin; Propranolol | 1987 |
[Prazosin in the treatment of hypertension: effect on lipid metabolism].
Topics: Blood Pressure; Cholesterol; Cholesterol, HDL; Humans; Hypertension; Lipids; Prazosin; Triglycerides | 1987 |
Antihypertensive drug treatment and the left ventricle.
Topics: Adult; Aged; Antihypertensive Agents; Diuretics; Echocardiography; Female; Heart; Humans; Hypertensi | 1987 |
The effect of chronic prazosin therapy on the response of the renin-angiotensin system in patients with essential hypertension.
Topics: Adult; Blood Pressure; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Posture; Prazosi | 1987 |
Central and peripheral contributions of the renin-angiotensin system in two models of experimental hypertension in rats.
Topics: Animals; Blood Pressure; Brain; Captopril; Disease Models, Animal; Hypertension; Hypertension, Renov | 1986 |
Management of urgent hypertension: a comparison of oral treatment regimens in the emergency department.
Topics: Administration, Oral; Antihypertensive Agents; Captopril; Clonidine; Drug Administration Schedule; E | 1986 |
[Long-term use of prazosin alone and combined with propranolol in patients with essential hypertension].
Topics: Adult; Drug Therapy, Combination; Hemodynamics; Humans; Hypertension; Middle Aged; Prazosin; Propran | 1986 |
[Efficacy of a graded plan for long-term prevention using antihypertensive drugs. Work Group for the Cooperative Study for the Testing of New Preparations for the Prevention of Arterial Hypertension (CSPPAH)].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Diastole; Drug Therapy, Combination; Heart Rate; Hum | 1987 |
[Interaction of digoxin with hydralazine and prazosin].
Topics: Adult; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Mal | 1986 |
Cerebral vasodilating and vasospasmolytic action of the cerebral circulation improver 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-4-([4-(2-methoxyphenyl)-1- piperazinyl]methyl)isoquinoline in experimental animals.
Topics: Animals; Brain Chemistry; Cats; Cerebrovascular Circulation; Decerebrate State; Dogs; Female; Hypert | 1987 |
Focal cerebral ischaemia and infarction due to antihypertensive therapy.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Cerebral Infarction; Cerebrovascular Circul | 1987 |
[Suicide attempt with Minipress].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Humans; Hypertension; Male; Prazosin; Suicide, Attemp | 1987 |
Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Female; Humans; Hy | 1987 |
[Recent topics in atherosclerosis].
Topics: Apolipoproteins; Arteriosclerosis; Cholesterol; Feeding Behavior; Humans; Hypertension; Prazosin; Tr | 1986 |
Intraindividual comparison of moxonidine and prazosin in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Imidazol | 1986 |
A pharmacokinetic study of prazosin in patients with varying degrees of chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Female; Half-Life; Humans; | 1986 |
Clinical pharmacology of selective alpha blockers. Hemodynamics and effects on lipid levels.
Topics: Hemodynamics; Humans; Hypertension; Kinetics; Lipids; Prazosin | 1987 |
Alpha blockade. An overview of efficacy data.
Topics: Drug Therapy, Combination; Hemodynamics; Humans; Hypertension; Lipids; Prazosin | 1987 |
Effect of antihypertensive therapy on the circadian blood pressure pattern.
Topics: Blood Pressure; Blood Pressure Determination; Circadian Rhythm; Humans; Hypertension; Male; Monitori | 1987 |
Antihypertensive therapy in the elderly. Effects on blood pressure and cerebral blood flow.
Topics: Aged; Blood Pressure; Cerebrovascular Circulation; Heart Rate; Humans; Hypertension; Middle Aged; Pr | 1987 |
[Serum lipids in patients with hypertension treated with prazosin].
Topics: Adult; Female; Humans; Hypertension; Lipids; Male; Middle Aged; Prazosin | 1986 |
Monitoring the 24-hour urinary frequency in spontaneously hypertensive, and in Wistar rats: effect of alpha-blockers.
Topics: Animals; Hypertension; Male; Phenoxybenzamine; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; U | 1986 |
Relationship of blood pressure response and the renin-angiotensin system to first-dose prazosin.
Topics: Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Quinazolines; Renin; Reni | 1985 |
Antihypertensive effects of a novel phenylpiperazine derivative, SGB-1534, on several hypertensive models of rats.
Topics: Animals; Antihypertensive Agents; Desoxycorticosterone; Hypertension; Hypertension, Renal; Lethal Do | 1985 |
Glucose metabolism during long-term treatment with prazosin.
Topics: Adolescent; Adult; Blood Glucose; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin; Mid | 1985 |
Lipids and hypertension. Implications of new guidelines for cholesterol management in the treatment of hypertension.
Topics: Adolescent; Adult; Child; Child, Preschool; Cholesterol; Cholestyramine Resin; Coronary Disease; Die | 1986 |
Serial measurements of systolic time intervals during treatment with hydrochlorothiazide alone and combined with other antihypertensive agents.
Topics: Antihypertensive Agents; Drug Therapy, Combination; Electrocardiography; Humans; Hydralazine; Hydroc | 1985 |
[Hypotensive effect and tolerability of a short course of treatment with prazosin (pratsiol) and hydralazine (apressin) in a cooperative study of new drugs for the prevention of arterial hypertension].
Topics: Adult; Drug Therapy, Combination; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Male; Midd | 1985 |
Effect of prazosin and yohimbine on systolic blood pressure and on renal norepinephrine content in DOCA-salt rats.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Drug Interactions; Hypertension; Kidney; Male; Norepi | 1985 |
Initial and long-term effects of prazosin on sympathetic vasopressor responses in essential hypertension.
Topics: Blood Pressure; Cold Temperature; Fingers; Heart Rate; Humans; Hypertension; Hypotension, Orthostati | 1985 |
Comments on hypertension symposium.
Topics: Humans; Hypertension; Nifedipine; Prazosin | 1985 |
[Comparative study of the relative bioavailabilities of two prazosin preparations in patients with essential hypertension].
Topics: Adult; Biological Availability; Female; Humans; Hypertension; Kinetics; Male; Middle Aged; Prazosin; | 1985 |
[Effect of obzidan and pratsiol therapy on the blood plasma lipid profile and on the high- and low-density lipoprotein apoproteins in hypertension patients].
Topics: Adult; Apolipoproteins; Apolipoproteins A; Blood Pressure; Drug Evaluation; Humans; Hypertension; Li | 1985 |
Interaction between clonidine and alpha blockers.
Topics: Animals; Blood Pressure; Clonidine; Drug Interactions; Drug Therapy, Combination; Humans; Hypertensi | 1985 |