Page last updated: 2024-11-03

prazosin and Aura

prazosin has been researched along with Aura in 6 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Research Excerpts

ExcerptRelevanceReference
" In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation."8.77Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985)
" In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation."4.77Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985)
"We found that the binding of [3H]prazosin, a selective ligand for alpha 1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats."3.67Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats. ( Barbaccia, ML; Iadarola, MJ; Laird, HE; Nicoletti, F; Pozzi, O, 1986)
", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule."1.43Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016)
"Chronic sound or electroshock-induced seizures caused down regulation of beta-adrenoceptors in frontal cortex and in hippocampus from GEPR-9s."1.31Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats. ( Cheong, JH; Choi, CR; Dailey, JW; Jobe, PC; Ko, KH; Reith, ME; Ryu, JR; Seo, DO; Shin, CY, 2000)
"Pretreatment with prazosin (1 microgram/side) significantly diminished the anticonvulsant effectiveness of methoxamine and nisoxetine while prazosin, by itself, had no effects on the seizure intensity."1.30Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study. ( Dailey, JW; Jobe, PC; Steenbergen, JL; Yan, QS, 1998)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Waszkielewicz, AM1
Gunia-Krzyżak, A1
Powroźnik, B1
Słoczyńska, K1
Pękala, E1
Walczak, M1
Bednarski, M1
Żesławska, E1
Nitek, W1
Marona, H1
Kombian, SB1
Ananthalakshmi, KV1
Edafiogho, IO1
Yan, QS1
Dailey, JW2
Steenbergen, JL1
Jobe, PC2
Seo, DO1
Shin, CY1
Ryu, JR1
Cheong, JH1
Choi, CR1
Reith, ME1
Ko, KH1
Nicoletti, F1
Barbaccia, ML1
Iadarola, MJ1
Pozzi, O1
Laird, HE1
Bregman, B1
Le Saux, F1
Trottier, S1
Chauvel, P1
Maurin, Y1

Reviews

1 review available for prazosin and Aura

ArticleYear
Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex.
    Journal of neural transmission, 1985, Volume: 63, Issue:2

    Topics: Animals; Cerebral Cortex; Chronic Disease; Clonidine; Cobalt; Dihydroalprenolol; Epilepsy; Iontophor

1985

Other Studies

5 other studies available for prazosin and Aura

ArticleYear
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru

2016
Norepinephrine and E139 interactions on epileptiform activity in the rat hippocampus in vitro.
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2008, Volume: 17, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cyclohexanes; Epilepsy; Hippocampus; Humans;

2008
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
    Brain research, 1998, Jan-12, Volume: 780, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Anti

1998
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
    European journal of pharmacology, 2000, May-19, Volume: 396, Issue:2-3

    Topics: Animals; Dihydroalprenolol; Electroshock; Epilepsy; Norepinephrine; Oxidopamine; Prazosin; Rats; Rat

2000
Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.
    Journal of neurochemistry, 1986, Volume: 46, Issue:1

    Topics: Animals; Carbachol; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Epilepsy; Hippocam

1986