prazosin has been researched along with Aura in 6 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Excerpt | Relevance | Reference |
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" In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation." | 8.77 | Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985) |
" In cobalt-induced epilepsy in the rat activity is associated with a cortical NA denervation." | 4.77 | Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex. ( Bregman, B; Chauvel, P; Le Saux, F; Maurin, Y; Trottier, S, 1985) |
"We found that the binding of [3H]prazosin, a selective ligand for alpha 1-adrenergic recognition sites, is significantly lower in the frontal cortex of the genetically epilepsy-prone rats (GEPRs), as compared with normal Sprague-Dawley rats." | 3.67 | Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats. ( Barbaccia, ML; Iadarola, MJ; Laird, HE; Nicoletti, F; Pozzi, O, 1986) |
", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
"Chronic sound or electroshock-induced seizures caused down regulation of beta-adrenoceptors in frontal cortex and in hippocampus from GEPR-9s." | 1.31 | Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats. ( Cheong, JH; Choi, CR; Dailey, JW; Jobe, PC; Ko, KH; Reith, ME; Ryu, JR; Seo, DO; Shin, CY, 2000) |
"Pretreatment with prazosin (1 microgram/side) significantly diminished the anticonvulsant effectiveness of methoxamine and nisoxetine while prazosin, by itself, had no effects on the seizure intensity." | 1.30 | Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study. ( Dailey, JW; Jobe, PC; Steenbergen, JL; Yan, QS, 1998) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (33.33) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 2 (33.33) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Waszkielewicz, AM | 1 |
Gunia-Krzyżak, A | 1 |
Powroźnik, B | 1 |
Słoczyńska, K | 1 |
Pękala, E | 1 |
Walczak, M | 1 |
Bednarski, M | 1 |
Żesławska, E | 1 |
Nitek, W | 1 |
Marona, H | 1 |
Kombian, SB | 1 |
Ananthalakshmi, KV | 1 |
Edafiogho, IO | 1 |
Yan, QS | 1 |
Dailey, JW | 2 |
Steenbergen, JL | 1 |
Jobe, PC | 2 |
Seo, DO | 1 |
Shin, CY | 1 |
Ryu, JR | 1 |
Cheong, JH | 1 |
Choi, CR | 1 |
Reith, ME | 1 |
Ko, KH | 1 |
Nicoletti, F | 1 |
Barbaccia, ML | 1 |
Iadarola, MJ | 1 |
Pozzi, O | 1 |
Laird, HE | 1 |
Bregman, B | 1 |
Le Saux, F | 1 |
Trottier, S | 1 |
Chauvel, P | 1 |
Maurin, Y | 1 |
1 review available for prazosin and Aura
Article | Year |
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Chronic cobalt-induced epilepsy: noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Chronic Disease; Clonidine; Cobalt; Dihydroalprenolol; Epilepsy; Iontophor | 1985 |
5 other studies available for prazosin and Aura
Article | Year |
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Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Norepinephrine and E139 interactions on epileptiform activity in the rat hippocampus in vitro.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cyclohexanes; Epilepsy; Hippocampus; Humans; | 2008 |
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Anti | 1998 |
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
Topics: Animals; Dihydroalprenolol; Electroshock; Epilepsy; Norepinephrine; Oxidopamine; Prazosin; Rats; Rat | 2000 |
Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats.
Topics: Animals; Carbachol; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Epilepsy; Hippocam | 1986 |