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prazosin and Asthma, Bronchial

prazosin has been researched along with Asthma, Bronchial in 16 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Research Excerpts

ExcerptRelevanceReference
"The effects of prazosin therapy were recently evaluated in ambulatory patients with essential hypertension and chronic obstructive pulmonary disease."9.06Prazosin in hypertensive patients with chronic bronchitis and asthma: a brief report. ( Chodosh, S; Pizzuto, D; Tuck, J, 1989)
"The role of prazosin, an alpha 1 adrenoceptor blocker, was investigated in patients with chronic stable asthma who continued to have symptoms despite conventional treatment."9.06Prazosin in the treatment of chronic asthma. ( Aitman, TJ; Baudouin, SV; Johnson, AJ, 1988)
"The effect of prazosin, a potent and specific alpha 1-adrenoceptor antagonist given by inhalation (total nebulized 2 mg) was compared with placebo in a double-blind randomized study of 10 atopic asthmatic children."9.05Prazosin, an alpha 1-adrenoceptor antagonist, partially inhibits exercise-induced asthma. ( Barnes, PJ; Vickers, H; Wilson, NM, 1981)
"Prazosin, a potent and selective alpha-adrenergic antagonist, was given by inhalation to nine asthmatic subjects aged 25-48 years (six with positive skin tests)."9.05Inhaled prazosin in asthma. ( Barnes, PJ; Dollery, CT; Ind, PW, 1981)
"Low levels of [3H]-dihydroergocryptine (DHE) (alpha adrenergic receptor) binding to peripheral blood mononuclear leukocytes from asthmatic subjects were significantly increased following incubation with histamine."7.68Effects of histamine on alpha adrenergic receptor expression on the lymphocytes of normal and asthmatic subjects. ( Easton, JG; Goldberg, BJ; Herman, FF; Kaplan, M; Lad, PM; Neidzin, H, 1990)
"The effect of 1 mg inhaled prazosin on bronchoconstriction induced by methoxamine was investigated in seven asthmatic subjects."7.67The action of prazosin and propylene glycol on methoxamine-induced bronchoconstriction in asthmatic subjects. ( Black, JL; Salome, C; Shaw, J; Yan, K, 1984)
"The animal and human pharmacology of several new drugs (prazosin, trimazosin, pirbuterol, and carbazeran) useful in the treatment of congestive heart failure (CHF) is delineated in relation to the pharmacology of other agents employed for CHF management."6.15Comparative pharmacology and clinical efficacy of newer agents in treatment of heart failure. ( Baird, JR; Blackburn, KJ; Cambridge, D; Constantine, JW; Ghaly, MS; Hayden, ML; McIlhenny, HM; Moore, PF; Olukotun, AY; Pullman, LG; Salsburg, DS; Saxton, CA; Shevde, S; Taylor, CR, 1981)
" This doxazosin dosage reduced the diastolic blood pressure on average from 103 to 91 mmHg (P = 0."5.28Doxazosin, a new alpha-1-antagonist drug, controls hypertension without causing airways obstruction in asthma and COPD. ( Biernacki, W; Flenley, DC, 1989)
"The effects of prazosin therapy were recently evaluated in ambulatory patients with essential hypertension and chronic obstructive pulmonary disease."5.06Prazosin in hypertensive patients with chronic bronchitis and asthma: a brief report. ( Chodosh, S; Pizzuto, D; Tuck, J, 1989)
"The role of prazosin, an alpha 1 adrenoceptor blocker, was investigated in patients with chronic stable asthma who continued to have symptoms despite conventional treatment."5.06Prazosin in the treatment of chronic asthma. ( Aitman, TJ; Baudouin, SV; Johnson, AJ, 1988)
"The effect of prazosin, a potent and specific alpha 1-adrenoceptor antagonist given by inhalation (total nebulized 2 mg) was compared with placebo in a double-blind randomized study of 10 atopic asthmatic children."5.05Prazosin, an alpha 1-adrenoceptor antagonist, partially inhibits exercise-induced asthma. ( Barnes, PJ; Vickers, H; Wilson, NM, 1981)
"Prazosin, a potent and selective alpha-adrenergic antagonist, was given by inhalation to nine asthmatic subjects aged 25-48 years (six with positive skin tests)."5.05Inhaled prazosin in asthma. ( Barnes, PJ; Dollery, CT; Ind, PW, 1981)
"Low levels of [3H]-dihydroergocryptine (DHE) (alpha adrenergic receptor) binding to peripheral blood mononuclear leukocytes from asthmatic subjects were significantly increased following incubation with histamine."3.68Effects of histamine on alpha adrenergic receptor expression on the lymphocytes of normal and asthmatic subjects. ( Easton, JG; Goldberg, BJ; Herman, FF; Kaplan, M; Lad, PM; Neidzin, H, 1990)
"The effect of 1 mg inhaled prazosin on bronchoconstriction induced by methoxamine was investigated in seven asthmatic subjects."3.67The action of prazosin and propylene glycol on methoxamine-induced bronchoconstriction in asthmatic subjects. ( Black, JL; Salome, C; Shaw, J; Yan, K, 1984)
" The autoradiographic distribution of alpha 1-adrenoceptors was investigated in non-diseased and asthmatic human lung by use of [3H]-prazosin (H-PZ)."3.67Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung. ( Goldie, RG; Paterson, JW; Rigby, PJ; Spina, D, 1989)
"Viable lymphocytes were used to investigate the binding of physiological concentrations of hormones and therapeutic concentrations of anti-asthmatic drugs to [3H]dihydroalprenolol (DHA, beta antagonist) and [3H]prazosin (alpha antagonist) receptor sites."3.67Modulation of lymphocyte adrenergic receptors by hormones and anti-asthmatic drugs. ( Davies, BH; Williams, WR, 1985)
" This doxazosin dosage reduced the diastolic blood pressure on average from 103 to 91 mmHg (P = 0."1.28Doxazosin, a new alpha-1-antagonist drug, controls hypertension without causing airways obstruction in asthma and COPD. ( Biernacki, W; Flenley, DC, 1989)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199015 (93.75)18.7374
1990's1 (6.25)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Marlin, GE2
Thompson, PJ2
Chow, CM2
Reddel, HK2
Cheng, S2
Barnes, P1
Barnes, PJ3
Wilson, NM1
Vickers, H1
Ind, PW1
Dollery, CT2
Kincaid-Smith, P1
MacDermot, J1
Black, JL1
Salome, C1
Yan, K1
Shaw, J1
Taylor, CR1
Baird, JR1
Blackburn, KJ1
Cambridge, D1
Constantine, JW1
Ghaly, MS1
Hayden, ML1
McIlhenny, HM1
Moore, PF1
Olukotun, AY1
Pullman, LG1
Salsburg, DS1
Saxton, CA1
Shevde, S1
Herman, FF1
Goldberg, BJ1
Lad, PM1
Neidzin, H1
Kaplan, M1
Easton, JG1
Spina, D1
Rigby, PJ1
Paterson, JW1
Goldie, RG1
Biernacki, W1
Flenley, DC1
Chodosh, S1
Tuck, J1
Pizzuto, D1
Williams, WR1
Davies, BH1
Baudouin, SV1
Aitman, TJ1
Johnson, AJ1
Riabova, KG1
Pashkova, TL1
Bichev, AA1

Reviews

1 review available for prazosin and Asthma, Bronchial

ArticleYear
Comparative pharmacology and clinical efficacy of newer agents in treatment of heart failure.
    American heart journal, 1981, Volume: 102, Issue:3 Pt 2

    Topics: Animals; Asthma; Carbamates; Cardiotonic Agents; Cardiovascular Agents; Clinical Trials as Topic; Dr

1981

Trials

7 trials available for prazosin and Asthma, Bronchial

ArticleYear
Bronchodilator action of prazosin.
    Lancet (London, England), 1981, Jan-24, Volume: 1, Issue:8213

    Topics: Adult; Asthma; Bronchi; Bronchodilator Agents; Clinical Trials as Topic; Double-Blind Method; Female

1981
Prazosin as bronchodilator.
    Lancet (London, England), 1981, Feb-14, Volume: 1, Issue:8216

    Topics: Asthma; Bronchodilator Agents; Clinical Trials as Topic; Double-Blind Method; Humans; Prazosin; Quin

1981
Prazosin, an alpha 1-adrenoceptor antagonist, partially inhibits exercise-induced asthma.
    The Journal of allergy and clinical immunology, 1981, Volume: 68, Issue:6

    Topics: Adolescent; Adrenergic alpha-Agonists; Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as T

1981
Inhaled prazosin in asthma.
    Thorax, 1981, Volume: 36, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adult; Albuterol; Asthma; Clinical Trials as Topic; Double-Blind Metho

1981
Comparative pharmacology and clinical efficacy of newer agents in treatment of heart failure.
    American heart journal, 1981, Volume: 102, Issue:3 Pt 2

    Topics: Animals; Asthma; Carbamates; Cardiotonic Agents; Cardiovascular Agents; Clinical Trials as Topic; Dr

1981
Prazosin in hypertensive patients with chronic bronchitis and asthma: a brief report.
    The American journal of medicine, 1989, Jan-23, Volume: 86, Issue:1B

    Topics: Asthma; Blood Pressure; Bronchitis; Chronic Disease; Forced Expiratory Volume; Humans; Hypertension;

1989
Prazosin in the treatment of chronic asthma.
    Thorax, 1988, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Aged; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Forced Expir

1988

Other Studies

9 other studies available for prazosin and Asthma, Bronchial

ArticleYear
Beta-adrenergic receptor blocking drugs in hypertension. With special reference to their use as initial therapy.
    The American journal of cardiology, 1984, Jan-27, Volume: 53, Issue:3

    Topics: Adrenergic beta-Antagonists; Asthma; Central Nervous System; Depression, Chemical; Heart Failure; Hu

1984
Increased pulmonary alpha-adrenergic and reduced beta-adrenergic receptors in experimental asthma.
    Nature, 1980, Jun-19, Volume: 285, Issue:5766

    Topics: Adenylyl Cyclases; Animals; Asthma; Dihydroalprenolol; Disease Models, Animal; Enzyme Activation; Gu

1980
The action of prazosin and propylene glycol on methoxamine-induced bronchoconstriction in asthmatic subjects.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:3

    Topics: Adult; Aged; Asthma; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methoxamine; Middle

1984
Bronchodilator activity of prazosin in patients with allergic rhinitis and asthma.
    British journal of clinical pharmacology, 1982, Volume: 13, Issue:3

    Topics: Adult; Aged; Asthma; Blood Pressure; Bronchodilator Agents; Double-Blind Method; Female; Forced Expi

1982
Effects of histamine on alpha adrenergic receptor expression on the lymphocytes of normal and asthmatic subjects.
    Annals of allergy, 1990, Volume: 65, Issue:1

    Topics: Asthma; Dihydroalprenolol; Dihydroergotoxine; Dose-Response Relationship, Drug; Histamine; Humans; M

1990
Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Adult; Asthma; Autoradiography; Bronchi; Carbachol; Humans; In Vitro Techniques; Iodine Radioisotope

1989
Doxazosin, a new alpha-1-antagonist drug, controls hypertension without causing airways obstruction in asthma and COPD.
    Journal of human hypertension, 1989, Volume: 3, Issue:6

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Asthma; Blood Pressure; Doxazosin; Female; Forced Expirat

1989
Modulation of lymphocyte adrenergic receptors by hormones and anti-asthmatic drugs.
    Journal of clinical & laboratory immunology, 1985, Volume: 16, Issue:3

    Topics: Asthma; Binding, Competitive; Dihydroalprenolol; Hormones; Humans; Kinetics; Lymphocytes; Prazosin;

1985
[Effect of the alpha-adrenergic blockader prazosin on physical effort-induced bronchospasm in bronchial asthma].
    Sovetskaia meditsina, 1988, Issue:8

    Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Drug Evaluation; Exercise Test; Female; Humans;

1988