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prazosin and Angiogenesis, Pathologic

prazosin has been researched along with Angiogenesis, Pathologic in 9 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Research Excerpts

ExcerptRelevanceReference
"Alteration of the oxidative stress of hepatocellular carcinoma (HCC) cells can influence the expressions of genes favored angiogenesis."5.38High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. ( Chuang, WL; Lin, ZY, 2012)
"A total of 34 men with benign prostatic hyperplasia (BPH) who have been on terazosin treatment (for the obstructive symptoms) were pathologically diagnosed with prostate cancer following surgery."3.71Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin. ( Borkowski, A; Isaacs, JT; Jacobs, SC; Keledjian, K; Kim, G; Kyprianou, N, 2001)
"Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy."1.48Murine breast cancer feed arteries are thin-walled with reduced α ( Boedtkjer, E; Froelunde, AS; Hansen, KB; Jessen, N; Kim, S; Ohlenbusch, M, 2018)
"Alteration of the oxidative stress of hepatocellular carcinoma (HCC) cells can influence the expressions of genes favored angiogenesis."1.38High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. ( Chuang, WL; Lin, ZY, 2012)
"Prazosin treatment of HUVECs resulted in reduced MCL-1 expression, increased Bad, and Bcl-xL expression, cytochrome c release, and induction of apoptosis via the intrinsic apoptosis pathway."1.37Anti-angiogenic effects and mechanism of prazosin. ( Chueh, SC; Guh, JH; Liao, CH; Yu, HJ, 2011)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Froelunde, AS1
Ohlenbusch, M1
Hansen, KB1
Jessen, N1
Kim, S1
Boedtkjer, E1
Liao, CH1
Guh, JH2
Chueh, SC1
Yu, HJ1
Lin, ZY1
Chuang, WL1
Da Silva-Azevedo, L1
Baum, O1
Zakrzewicz, A1
Pries, AR1
Pan, SL1
Huang, YW1
Chern, JW1
Chou, JY1
Teng, CM1
Tahmatzopoulos, A1
Lagrange, CA1
Zeng, L1
Mitchell, BL1
Conner, WT1
Kyprianou, N2
Ke, Z1
Zhang, X1
Ma, L1
Wang, L1
Zhou, A1
Egginton, S1
Hudlická, O1
Brown, MD1
Keledjian, K1
Borkowski, A1
Kim, G1
Isaacs, JT1
Jacobs, SC1

Other Studies

9 other studies available for prazosin and Angiogenesis, Pathologic

ArticleYear
Murine breast cancer feed arteries are thin-walled with reduced α
    Breast cancer research : BCR, 2018, 03-22, Volume: 20, Issue:1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Arteries; Breast Neoplasms; Calcium; Female; Gene

2018
Anti-angiogenic effects and mechanism of prazosin.
    The Prostate, 2011, Jun-15, Volume: 71, Issue:9

    Topics: Adrenergic alpha-1 Receptor Antagonists; Angiogenesis Inhibitors; Apoptosis; Blotting, Western; Cell

2011
High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2012, Volume: 66, Issue:8

    Topics: Amphotericin B; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Proliferation; Chemokine CC

2012
Vascular endothelial growth factor is expressed in endothelial cells isolated from skeletal muscles of nitric oxide synthase knockout mice during prazosin-induced angiogenesis.
    Biochemical and biophysical research communications, 2002, Oct-11, Volume: 297, Issue:5

    Topics: Adrenergic alpha-Antagonists; Alkaline Phosphatase; Animals; Electrophoresis, Polyacrylamide Gel; En

2002
Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells.
    The Journal of urology, 2003, Volume: 169, Issue:2

    Topics: Adenocarcinoma; Animals; Apoptosis; Endothelium, Vascular; Humans; Male; Mice; Mice, Nude; Neovascul

2003
Effect of terazosin on tissue vascularity and apoptosis in transitional cell carcinoma of bladder.
    Urology, 2005, Volume: 65, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Carcinoma,

2005
Expression of DPC4/Smad4 in non-small-cell lung carcinoma and its relationship with angiogenesis.
    Neoplasma, 2008, Volume: 55, Issue:4

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Humans; Immunohistochemistry;

2008
Internal division of capillaries in rat skeletal muscle in response to chronic vasodilator treatment with alpha1-antagonist prazosin.
    Cell and tissue research, 1998, Volume: 293, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Capillaries; Male; Muscle, Skeletal; Neovascularization, Path

1998
Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin.
    The Prostate, 2001, Jul-01, Volume: 48, Issue:2

    Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Apoptosis; Cell Division; Endothelial Growth

2001