prazosin has been researched along with Angiogenesis, Pathologic in 9 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alteration of the oxidative stress of hepatocellular carcinoma (HCC) cells can influence the expressions of genes favored angiogenesis." | 5.38 | High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. ( Chuang, WL; Lin, ZY, 2012) |
| "A total of 34 men with benign prostatic hyperplasia (BPH) who have been on terazosin treatment (for the obstructive symptoms) were pathologically diagnosed with prostate cancer following surgery." | 3.71 | Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin. ( Borkowski, A; Isaacs, JT; Jacobs, SC; Keledjian, K; Kim, G; Kyprianou, N, 2001) |
| "Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy." | 1.48 | Murine breast cancer feed arteries are thin-walled with reduced α ( Boedtkjer, E; Froelunde, AS; Hansen, KB; Jessen, N; Kim, S; Ohlenbusch, M, 2018) |
| "Alteration of the oxidative stress of hepatocellular carcinoma (HCC) cells can influence the expressions of genes favored angiogenesis." | 1.38 | High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. ( Chuang, WL; Lin, ZY, 2012) |
| "Prazosin treatment of HUVECs resulted in reduced MCL-1 expression, increased Bad, and Bcl-xL expression, cytochrome c release, and induction of apoptosis via the intrinsic apoptosis pathway." | 1.37 | Anti-angiogenic effects and mechanism of prazosin. ( Chueh, SC; Guh, JH; Liao, CH; Yu, HJ, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Froelunde, AS | 1 |
| Ohlenbusch, M | 1 |
| Hansen, KB | 1 |
| Jessen, N | 1 |
| Kim, S | 1 |
| Boedtkjer, E | 1 |
| Liao, CH | 1 |
| Guh, JH | 2 |
| Chueh, SC | 1 |
| Yu, HJ | 1 |
| Lin, ZY | 1 |
| Chuang, WL | 1 |
| Da Silva-Azevedo, L | 1 |
| Baum, O | 1 |
| Zakrzewicz, A | 1 |
| Pries, AR | 1 |
| Pan, SL | 1 |
| Huang, YW | 1 |
| Chern, JW | 1 |
| Chou, JY | 1 |
| Teng, CM | 1 |
| Tahmatzopoulos, A | 1 |
| Lagrange, CA | 1 |
| Zeng, L | 1 |
| Mitchell, BL | 1 |
| Conner, WT | 1 |
| Kyprianou, N | 2 |
| Ke, Z | 1 |
| Zhang, X | 1 |
| Ma, L | 1 |
| Wang, L | 1 |
| Zhou, A | 1 |
| Egginton, S | 1 |
| Hudlická, O | 1 |
| Brown, MD | 1 |
| Keledjian, K | 1 |
| Borkowski, A | 1 |
| Kim, G | 1 |
| Isaacs, JT | 1 |
| Jacobs, SC | 1 |
9 other studies available for prazosin and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Murine breast cancer feed arteries are thin-walled with reduced α
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Arteries; Breast Neoplasms; Calcium; Female; Gene | 2018 |
Anti-angiogenic effects and mechanism of prazosin.
Topics: Adrenergic alpha-1 Receptor Antagonists; Angiogenesis Inhibitors; Apoptosis; Blotting, Western; Cell | 2011 |
High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells.
Topics: Amphotericin B; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Proliferation; Chemokine CC | 2012 |
Vascular endothelial growth factor is expressed in endothelial cells isolated from skeletal muscles of nitric oxide synthase knockout mice during prazosin-induced angiogenesis.
Topics: Adrenergic alpha-Antagonists; Alkaline Phosphatase; Animals; Electrophoresis, Polyacrylamide Gel; En | 2002 |
Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells.
Topics: Adenocarcinoma; Animals; Apoptosis; Endothelium, Vascular; Humans; Male; Mice; Mice, Nude; Neovascul | 2003 |
Effect of terazosin on tissue vascularity and apoptosis in transitional cell carcinoma of bladder.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Carcinoma, | 2005 |
Expression of DPC4/Smad4 in non-small-cell lung carcinoma and its relationship with angiogenesis.
Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Humans; Immunohistochemistry; | 2008 |
Internal division of capillaries in rat skeletal muscle in response to chronic vasodilator treatment with alpha1-antagonist prazosin.
Topics: Adrenergic alpha-Antagonists; Animals; Capillaries; Male; Muscle, Skeletal; Neovascularization, Path | 1998 |
Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Apoptosis; Cell Division; Endothelial Growth | 2001 |