prazosin has been researched along with Alloxan Diabetes in 48 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate whether alpha1-adrenoceptors are involved in pain behaviors in streptozotocin (STZ)-induced diabetic rats, we measured the effects of phenylephrine or prazosin on allodynia in the diabetic rats." | 3.70 | Alpha1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia. ( Hur, GM; Jeon, BH; Kim, KJ; Lee, YH; Park, SJ; Ryu, TG; Yang, EJ, 2000) |
| "Systemic hypertension is common in individuals with non-insulin-dependent diabetes (NIDD) and, in this population, markedly increases the risk for cardiovascular complications." | 1.31 | NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation. ( Mozaffari, MS; Patel, C; Schaffer, SW; Warren, BK, 2000) |
| " Methoxamine increased the tension of both normal and diabetic ventricles, but in diabetic ones, the dose-response curve to methoxamine was shifted to the left and the efficacy of the alpha-agonist was enhanced." | 1.27 | Alpha-adrenergic supersensitivity and decreased number of alpha-adrenoceptors in heart from acute diabetic rats. ( Borda, ES; Sterin-Borda, L; Wald, M, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (33.33) | 18.7374 |
| 1990's | 16 (33.33) | 18.2507 |
| 2000's | 13 (27.08) | 29.6817 |
| 2010's | 3 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adewoye, EO | 1 |
| Ige, AO | 1 |
| Dunford, EC | 1 |
| Leclair, E | 1 |
| Aiken, J | 1 |
| Mandel, ER | 1 |
| Haas, TL | 1 |
| Birot, O | 1 |
| Riddell, MC | 1 |
| Liu, X | 1 |
| Jing, XY | 1 |
| Jin, S | 1 |
| Li, Y | 1 |
| Liu, L | 1 |
| Yu, YL | 1 |
| Liu, XD | 2 |
| Xie, L | 2 |
| Colivicchi, MA | 1 |
| Raimondi, L | 1 |
| Bianchi, L | 1 |
| Tipton, KF | 1 |
| Pirisino, R | 1 |
| Della Corte, L | 1 |
| Schulingkamp, RJ | 1 |
| Aloyo, V | 1 |
| Tallarida, RJ | 1 |
| Raffa, RB | 1 |
| Hajizadeh, S | 1 |
| Shiran, K | 1 |
| Fathollahi, Y | 1 |
| Liu, YC | 1 |
| Liu, HY | 1 |
| Yang, HW | 1 |
| Wen, T | 1 |
| Shang, Y | 1 |
| Wang, GJ | 1 |
| Latifpour, J | 1 |
| McNeill, JH | 4 |
| Scarborough, NL | 1 |
| Carrier, GO | 2 |
| Williams, RS | 1 |
| Schaible, TF | 1 |
| Scheuer, J | 1 |
| Kennedy, R | 1 |
| Dighe, RR | 1 |
| Rojas, FJ | 1 |
| Birnbaumer, L | 1 |
| Garber, AJ | 1 |
| Rodrigues, B | 1 |
| Grassby, PF | 1 |
| Battell, ML | 1 |
| Lee, SY | 1 |
| Goyal, RK | 1 |
| Bangaru, RA | 1 |
| Lakkad, NB | 1 |
| Rao, MV | 1 |
| Iwai, T | 1 |
| Irlbeck, M | 1 |
| Zimmer, HG | 1 |
| Thulesen, J | 1 |
| Poulsen, SS | 1 |
| Jørgensen, PE | 1 |
| Nexø, E | 1 |
| Martínez-Nieves, B | 1 |
| Dunbar, JC | 1 |
| Mozaffari, MS | 1 |
| Patel, C | 1 |
| Warren, BK | 1 |
| Schaffer, SW | 1 |
| Lee, YH | 1 |
| Ryu, TG | 1 |
| Park, SJ | 1 |
| Yang, EJ | 1 |
| Jeon, BH | 1 |
| Hur, GM | 1 |
| Kim, KJ | 1 |
| Obrosova, IG | 2 |
| Van Huysen, C | 1 |
| Fathallah, L | 1 |
| Cao, X | 1 |
| Stevens, MJ | 2 |
| Greene, DA | 1 |
| Gallego, M | 1 |
| Casis, E | 1 |
| Izquierdo, MJ | 1 |
| Casis, O | 1 |
| Lang, HJ | 1 |
| Cheng, JT | 1 |
| Liu, IM | 1 |
| Chi, TC | 1 |
| Tzeng, TF | 1 |
| Ramasamy, S | 1 |
| Hodgson, WC | 1 |
| Ventura, S | 1 |
| Fitzgerald, SM | 1 |
| Brands, MW | 1 |
| Saitoh, A | 1 |
| Onodera, K | 1 |
| Morita, K | 1 |
| Sodeyama, M | 1 |
| Kamei, J | 1 |
| Lee, SL | 1 |
| Dhalla, NS | 1 |
| Koltai, MZ | 1 |
| Rösen, P | 1 |
| Hadházy, P | 1 |
| Aranyi, Z | 1 |
| Ballagi-Pordány, G | 1 |
| Pogátsa, G | 1 |
| Austin, CE | 1 |
| Chess-Williams, R | 1 |
| Buczek-Thomas, JA | 1 |
| Jaspers, SR | 1 |
| Miller, TB | 1 |
| Abebe, W | 2 |
| MacLeod, KM | 2 |
| Cameron, NE | 1 |
| Cotter, MA | 1 |
| Ferguson, K | 1 |
| Robertson, S | 1 |
| Radcliffe, MA | 1 |
| Harris, KH | 1 |
| Inazu, M | 2 |
| Sakai, Y | 2 |
| Homma, I | 2 |
| Xiang, H | 1 |
| Aihara, K | 1 |
| Inoue, K | 1 |
| Sunaga, K | 1 |
| Ogihara, M | 1 |
| Bitar, M | 1 |
| Koulu, M | 1 |
| Rapoport, SI | 1 |
| Linnoila, M | 1 |
| Martin, S | 1 |
| Kolb-Bachofen, V | 1 |
| Kiesel, U | 1 |
| Kolb, H | 1 |
| Studer, RK | 1 |
| Ganas, L | 1 |
| Ostenson, CG | 1 |
| Cattaneo, AG | 1 |
| Doxey, JC | 1 |
| Efendic, S | 1 |
| Kaschube, M | 1 |
| Möller-Hartmann, H | 1 |
| Zetler, G | 1 |
| Wald, M | 1 |
| Borda, ES | 1 |
| Sterin-Borda, L | 1 |
| White, RE | 1 |
| Jackson, CV | 1 |
| McGrath, GM | 1 |
| Ramos, OL | 1 |
| Kilgour, E | 1 |
| Vernon, RG | 1 |
| Sulakhe, SJ | 1 |
| Moss, HE | 1 |
| Crowe, R | 1 |
| Burnstock, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.[NCT00846092] | Phase 1 | 4 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
48 other studies available for prazosin and Alloxan Diabetes
| Article | Year |
|---|---|
Effect of magnesium on gastrointestinal transit time in normal and diabetic rats: possible mechanism of action.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Diabetes Mellitus, Expe | 2012 |
The effects of voluntary exercise and prazosin on capillary rarefaction and metabolism in streptozotocin-induced diabetic male rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Blood Glucose; Combined Modality Therapy; Diabetes | 2017 |
Insulin suppresses the expression and function of breast cancer resistance protein in primary cultures of rat brain microvessel endothelial cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2011 |
Taurine prevents streptozotocin impairment of hormone-stimulated glucose uptake in rat adipocytes.
Topics: Adipocytes; Adrenergic Agonists; Adrenergic Antagonists; Animals; Deoxyglucose; Diabetes Mellitus, E | 2004 |
Changes in aorta alpha1-adrenoceptor number and affinity during one year of streptozotocin-induced diabetes in rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thora | 2005 |
Responsiveness of vascular alpha1-adrenoceptors of diabetic rat knee joint to phenylephrine in acute inflammation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arthritis; Diabetes Mellitus, Expe | 2005 |
Impaired expression and function of breast cancer resistance protein (Bcrp) in brain cortex of streptozocin-induced diabetic rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2007 |
Cardiac autonomic receptors: effect of long-term experimental diabetes.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Dihydroalprenolol; Heart; Kinetics; Lung; Mal | 1984 |
Nifedipine and alpha adrenoceptors in rat aorta. II. Role of extracellular calcium in enhanced alpha-2 adrenoceptor-mediated contraction in diabetes.
Topics: Animals; Aorta; Calcium; Clonidine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Dru | 1984 |
Effects of experimental diabetes on adrenergic and cholinergic receptors of rat myocardium.
Topics: Animals; Blood Glucose; Body Weight; Cell Membrane; Diabetes Mellitus, Experimental; Diet, Diabetic; | 1983 |
Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Enzyme Activation; Femal | 1984 |
Hypertriglyceridemia in experimental diabetes: relationship to cardiac dysfunction.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Cholesterol; Clofibrate; Diabetes Mellitus, Experim | 1994 |
Effect of chronic treatment with atenolol and prazosin in streptozotocin induced diabetic rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Diabetes Mellitus, Exp | 1996 |
Measurement of left ventricular maximal isovolumetric pressure in rats: effects of antihypertensive drugs and diabetes mellitus.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Animals | 1998 |
Adrenergic blockade in diabetic and uninephrectomized rats: effects on renal size and on renal and urinary contents of epidermal growth factor.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Diabetes Mellitus | 1999 |
Vascular dilatatory responses to sodium nitroprusside (SNP) and alpha-adrenergic antagonism in female and male normal and diabetic rats.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Diabetes Mellitus, Experimental; Female; Male; Nitr | 1999 |
NaCl-induced hypertensive rat model of non-insulin-dependent diabetes: role of sympathetic modulation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agon | 2000 |
Alpha1-adrenoceptors involvement in painful diabetic neuropathy: a role in allodynia.
Topics: Adrenergic alpha-Antagonists; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Gangl | 2000 |
Evaluation of alpha(1)-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Blood Glucose; Blood Pressure; Body Weight; Cre | 2000 |
Restoration of cardiac transient outward potassium current by norepinephrine in diabetic rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autonomic Nervous System Disease | 2000 |
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.
Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, | 2001 |
Release of beta-endorphin by prostaglandin E2 to lower plasma glucose in streptozotocin-induced diabetic rats.
Topics: Adrenalectomy; Adrenergic alpha-Antagonists; Animals; beta-Endorphin; Blood Glucose; Diabetes Mellit | 2001 |
Protein kinase C and the sub-sensitivity and sub-reactivity of the diabetic rat prostate gland to noradrenaline.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atrop | 2002 |
Hypertension in L-NAME-treated diabetic rats depends on an intact sympathetic nervous system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin II; Animals; Blood Glucose; B | 2002 |
Prazosin inhibits spontaneous locomotor activity in diabetic mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Diabetes Mellitus, Experimental; Dose-Response Rel | 2002 |
Ca(2+)-channels and adrenoceptors in diabetic skeletal muscle.
Topics: Animals; Calcium Channels; Diabetes Mellitus, Experimental; Dihydroalprenolol; Kinetics; Male; Muscl | 1992 |
Disturbed lipid metabolism in diabetic coronary vessels.
Topics: Alloxan; Animals; Arachidonic Acids; Aspirin; Coronary Circulation; Coronary Vessels; Diabetes Melli | 1992 |
Transient elevation of cardiac beta-adrenoceptor responsiveness and receptor number in the streptozotocin-diabetic rat.
Topics: Animals; Binding Sites; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; Dihydroalprenolol; | 1992 |
Adrenergic activation of glycogen phosphorylase in primary culture diabetic cardiomyocytes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme | 1992 |
Enhanced arterial contractility to noradrenaline in diabetic rats is associated with increased phosphoinositide metabolism.
Topics: Animals; Aorta, Thoracic; Arteries; Blood Glucose; Diabetes Mellitus, Experimental; Inositol; Inosit | 1991 |
Effects of chronic alpha-adrenergic receptor blockade on peripheral nerve conduction, hypoxic resistance, polyols, Na(+)-K(+)-ATPase activity, and vascular supply in STZ-D rats.
Topics: Action Potentials; Alcohols; Animals; Capillaries; Cell Hypoxia; Diabetes Mellitus, Experimental; Di | 1991 |
Enhanced contractile responses of arteries from diabetic rats to alpha 1-adrenoceptor stimulation in the absence and presence of extracellular calcium.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Arteries; Calcium; Clonidine; Diabetes Mellitus | 1990 |
Contractile responses and calcium mobilization in renal arteries of diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic responses in diabetic hearts.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Inositol 1,4,5-Trisphosp | 1991 |
Relations between contractile responses and beta-adrenoceptors in gastric fundus of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smo | 1991 |
Effects of calcium channel blockers and hydralazine on plasma glucose levels in streptozotocin-induced diabetic rats in vivo.
Topics: Animals; Blood Glucose; Blood Pressure; Calcium Channel Blockers; Catecholamines; Diabetes Mellitus, | 1990 |
Diabetes-induced alteration in brain monoamine metabolism in rats.
Topics: Animals; Biogenic Amines; Blood Glucose; Body Weight; Brain; Choline O-Acetyltransferase; Diabetes M | 1986 |
Pathogenesis of low dose streptozotocin induced diabetes in mice: requirement for alpha 1-adrenoceptor activation and vasoactive amine release.
Topics: Animals; Cromolyn Sodium; Cyproheptadine; Diabetes Mellitus, Experimental; Histamine Antagonists; Me | 1989 |
Effect of diabetes on hormone-stimulated and basal hepatocyte calcium metabolism.
Topics: Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Diabetes Mellitus, Experimental; Epinephrin | 1989 |
Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidi | 1989 |
The field-stimulated vas deferens of the streptozotocin-diabetic mouse: effects of prazosin, alpha, beta-methylene ATP, and variation of stimulation parameters.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Electr | 1989 |
Alpha-adrenergic supersensitivity and decreased number of alpha-adrenoceptors in heart from acute diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Kinetics; Male; Methoxam | 1988 |
Enhanced vascular alpha-adrenergic neuroeffector system in diabetes: importance of calcium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Clonidine; Diabetes Melli | 1988 |
Alterations in alpha 1-adrenoceptor stimulation of isolated atria from experimental diabetic rats.
Topics: Animals; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; Heart; Heart Atria; In Vitro Techn | 1986 |
Diabetes mellitus and hypertension. State of the art lecture.
Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Diabetes Mellitus, Experimental; Diabetes Mellit | 1988 |
Catecholamine activation of pyruvate dehydrogenase in white adipose tissue of the rat in vivo.
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Epinephrine; Female; In | 1987 |
Hepatic adrenergic receptors in the genetically diabetic C57 BL/KsJ (db/db) mouse.
Topics: Animals; Body Weight; Cell Membrane; Diabetes Mellitus, Experimental; Dihydroalprenolol; Heterozygot | 1987 |
The seminal vesicle in eight and 16 week streptozotocin-induced diabetic rats: adrenergic, cholinergic and peptidergic innervation.
Topics: Acetylcholine; Adrenergic Fibers; Animals; Cholinergic Fibers; Diabetes Mellitus, Experimental; Diab | 1987 |