prazosin has been researched along with Aging in 99 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats." | 7.69 | Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996) |
| " The Cmax was identical in the two groups, and the time to Cmax was 84 min in the elderly and 114 min in the young subjects." | 6.68 | The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin. ( Andros, E; Detmar-Hanna, D; Gal, J; Gerber, JG; Suteparuk, S, 1996) |
| "The effects of aging on alpha(1)-adrenoceptor (alpha(1)-AR)-mediated contractile response in endothelium-removed aortic preparations isolated from 5- to 40-week-old (5-, 6-, 8-, 10-, 20-, 40-weeks) mice were studied in the presence of propranolol." | 3.73 | Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation. ( Funabiki, M; Koike, K; Michikawa, H; Tanaka, Y, 2006) |
| "Blockade of alpha(1)-adrenoreceptors with prazosin produces bradycardia." | 3.71 | Age-related peculiarities of the effect of alpha-adrenoreceptor blockade on cardiac function in rats. ( Zefirov, AL; Zefirov, TL; Ziyatdinova, NI, 2002) |
| "To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats." | 3.69 | Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996) |
| "To study the effects of aging on the blood pressure potency of phenylephrine, 6-, 10- and 40-week-old rats were used." | 3.69 | Age-related changes in alpha-adrenoceptor-mediated blood pressure in the rat: relationship between the potency for phenylephrine and the maximum number of binding sites. ( Kanai, S; Koike, K; Ohtsuki, H; Satoh, M; Takayanagi, I, 1996) |
| " To test the hypothesis that hypoxia-induced developmental and vessel specific cerebral artery contractility changes are mediated, in part, by changes in alpha1-adrenergic receptor (alpha1-AR) density and/or NE-induced inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] responses, we performed the following study." | 3.69 | High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries. ( Longo, LD; Ueno, N; Zhang, L; Zhao, Y, 1997) |
| " We investigated, using rats at 2, 12 and 24 months of age, the effect of aging on ventricular alpha 1-adrenoceptor responsiveness by measuring the [3H]prazosin binding, [3H]inositol phosphate formation, the cholesterol/phospholipid ratio and membrane viscosity." | 3.67 | Age-related changes in [3H]prazosin binding and phosphoinositide hydrolysis in rat ventricular myocardium. ( Miyamoto, A; Ohshika, H, 1989) |
| "nilvadipine or terazosin was administered for 2 weeks in a randomized crossover manner." | 2.69 | Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke. ( Abe, I; Fujishima, M; Hasuo, Y; Nishino, Y; Onaka, U; Setoguchi, M, 1998) |
| "Prazosin and terazosin are two alpha 1-adrenoceptor blocking agents, their principal difference being the longer half-life of terazosin." | 2.66 | Effect of age on pharmacokinetics of and blood pressure responses to prazosin and terazosin. ( Conway, EL; Drummer, OH; Louis, WJ; McNeil, JJ; Workman, BS, 1987) |
| " For both routes of administration, the only pharmacokinetic variables significantly correlated with age were terminal elimination rate constant and the area under the plasma concentration-time curve (AUC)." | 2.66 | Effect of age on the pharmacokinetics of orally and intravenously administered terazosin. ( Glassman, HN; Jordan, DC; Luther, RR; Sennello, LT; Sonders, RC; Tolman, KG, 1988) |
| " Next, we determined norepinephrine dose-response relations before and after prazosin, yohimbine, and benextramine." | 1.29 | Effects of maturation on alpha-adrenergic receptor affinity and occupancy in small cerebral arteries. ( Elliott, SR; Pearce, WJ, 1994) |
| "Narcolepsy is a genetically determined disorder of sleep characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep that affects both humans and animals." | 1.29 | Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. ( Arrigoni, J; Ciaranello, RD; Dement, WC; Edgar, DM; Mignot, E; Nishino, S; Reid, MS; Sharp, LH; Siegel, JM, 1993) |
| "1." | 1.28 | Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. ( Christ, GJ; Maayani, S; Melman, A; Valcic, M, 1990) |
| "[3H]Prazosin binding was typical of an alpha 1-adrenergic receptor, and (-)epinephrine affinity for the [3H]prazosin-binding sites was not altered in the presence of 10(-5) M guanylyl-imidodiphosphate." | 1.27 | Normal ontogeny of alpha 1-adrenergic receptor in rat liver is thyroid hormone dependent. ( Noguchi, A, 1983) |
| " In young subjects the mean bioavailability was 65% and the mean terminal elimination half-lives were 9." | 1.27 | Clinical pharmacological studies with doxazosin. ( Elliott, HL; Meredith, PA; Reid, JL; Vincent, J, 1986) |
| " 258, 5103-5109) but did not affect the dose-response curves for norepinephrine-induced Ca2+ mobilization and phosphorylase activation in these cells." | 1.27 | Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age. ( Blackmore, PF; Charest, R; Exton, JH; Lynch, CJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (41.41) | 18.7374 |
| 1990's | 41 (41.41) | 18.2507 |
| 2000's | 12 (12.12) | 29.6817 |
| 2010's | 5 (5.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, A | 1 |
| Veeriah, V | 1 |
| Xi, P | 1 |
| Labella, R | 1 |
| Chen, J | 1 |
| Romeo, SG | 1 |
| Ramasamy, SK | 1 |
| Kusumbe, AP | 1 |
| Coccurello, R | 1 |
| Bielawski, A | 1 |
| Zelek-Molik, A | 1 |
| Vetulani, J | 1 |
| Kowalska, M | 1 |
| D'Amato, FR | 1 |
| Nalepa, I | 1 |
| Skelly, MJ | 1 |
| Chappell, AE | 1 |
| Carter, E | 1 |
| Weiner, JL | 1 |
| Dmitrieva, N | 1 |
| Zhang, G | 1 |
| Nagabukuro, H | 1 |
| Kluess, HA | 1 |
| Stone, AJ | 1 |
| Evanson, KW | 1 |
| Pelletier, A | 1 |
| Delanaud, S | 1 |
| Décima, P | 1 |
| Thuroczy, G | 1 |
| de Seze, R | 1 |
| Cerri, M | 1 |
| Bach, V | 1 |
| Libert, JP | 1 |
| Loos, N | 1 |
| Ziyatdinova, NI | 1 |
| Zefirov, AL | 1 |
| Zefirov, TL | 1 |
| Knauber, J | 2 |
| Müller, WE | 2 |
| Collier, TJ | 1 |
| Greene, JG | 1 |
| Felten, DL | 1 |
| Stevens, SY | 1 |
| Collier, KS | 1 |
| Moore, TL | 1 |
| Schettler, SP | 1 |
| Killiany, RJ | 1 |
| Herndon, JG | 1 |
| Luebke, JI | 1 |
| Moss, MB | 1 |
| Rosene, DL | 1 |
| Passmore, JC | 1 |
| Rowell, PP | 1 |
| Joshua, IG | 1 |
| Porter, JP | 1 |
| Patel, DH | 1 |
| Falcone, JC | 1 |
| Wallace, A | 1 |
| Knight, GE | 1 |
| Cowen, T | 1 |
| Burnstock, G | 1 |
| Tanaka, Y | 2 |
| Funabiki, M | 1 |
| Michikawa, H | 1 |
| Koike, K | 4 |
| Zhou, LW | 1 |
| Weiss, B | 1 |
| Freilich, JS | 1 |
| Greenberg, LH | 1 |
| Hamilton, CA | 1 |
| Howe, CA | 1 |
| Reid, JL | 2 |
| Prinsley, DM | 1 |
| Harris, A | 1 |
| Swamy, VC | 1 |
| Triggle, DJ | 1 |
| Waters, DH | 1 |
| Pulliam, JP | 1 |
| McCarron, DA | 1 |
| Dausse, JP | 2 |
| Le Quan-Bui, KH | 1 |
| Meyer, P | 2 |
| Morris, MJ | 1 |
| Devynck, MA | 1 |
| D'Armiento, M | 1 |
| Lacerna, F | 1 |
| Lauro, R | 1 |
| Modesti, A | 1 |
| Verna, R | 1 |
| Ceccarelli, G | 1 |
| Noguchi, A | 2 |
| Whitsett, JA | 1 |
| Dickman, L | 1 |
| Partilla, JS | 1 |
| Hoopes, MT | 1 |
| Ito, H | 1 |
| Dax, EM | 1 |
| Roth, GS | 3 |
| Morgan, NG | 1 |
| Blackmore, PF | 2 |
| Exton, JH | 2 |
| Moriyama, N | 4 |
| Kurimoto, S | 1 |
| Inagaki, O | 1 |
| Takanashi, M | 1 |
| Hamada, K | 1 |
| Kawabe, K | 3 |
| Simmons, KE | 1 |
| Jones, DJ | 1 |
| Brawer, MK | 1 |
| Tanaka, H | 1 |
| Manita, S | 1 |
| Matsuda, T | 1 |
| Adachi, M | 1 |
| Shigenobu, K | 1 |
| Nagao, T | 1 |
| Fujita, A | 1 |
| Takeuchi, T | 1 |
| Hata, F | 1 |
| Gascón, S | 1 |
| Dierssen, M | 1 |
| Màrmol, F | 1 |
| Vivas, NM | 2 |
| Badia, A | 1 |
| Elliott, SR | 1 |
| Pearce, WJ | 1 |
| Paolisso, G | 1 |
| Gambardella, A | 1 |
| Galzerano, D | 1 |
| Varricchio, M | 1 |
| Mignot, E | 1 |
| Nishino, S | 1 |
| Sharp, LH | 1 |
| Arrigoni, J | 1 |
| Siegel, JM | 1 |
| Reid, MS | 1 |
| Edgar, DM | 1 |
| Ciaranello, RD | 1 |
| Dement, WC | 1 |
| Riekkinen, P | 2 |
| Sirviö, J | 1 |
| Toivanen, L | 1 |
| Riekkinen, M | 1 |
| Lammintausta, R | 1 |
| Azuma, H | 1 |
| Huguet, F | 1 |
| Comoy, E | 1 |
| Piriou, A | 1 |
| Bohuon, C | 1 |
| Keeney, SE | 1 |
| Oelberg, DG | 1 |
| Liu, QY | 1 |
| Karpinski, E | 1 |
| Pang, PK | 1 |
| McCarty, R | 1 |
| Lee, JH | 1 |
| Andros, E | 1 |
| Detmar-Hanna, D | 1 |
| Suteparuk, S | 1 |
| Gal, J | 1 |
| Gerber, JG | 1 |
| Davidow, LW | 1 |
| Buñag, RD | 1 |
| Satoh, M | 1 |
| Kanai, S | 1 |
| Ohtsuki, H | 1 |
| Takayanagi, I | 4 |
| Chen, C | 1 |
| Noland, KA | 1 |
| Kalu, DN | 1 |
| Ueno, N | 1 |
| Zhao, Y | 1 |
| Zhang, L | 1 |
| Longo, LD | 1 |
| Vila, E | 1 |
| Tabernero, A | 1 |
| Giraldo, J | 1 |
| Arribas, SM | 1 |
| Setoguchi, M | 1 |
| Onaka, U | 1 |
| Abe, I | 1 |
| Hasuo, Y | 1 |
| Nishino, Y | 1 |
| Fujishima, M | 1 |
| Nigmatullina, RR | 1 |
| Abzalov, RA | 1 |
| Minnibaev, ESh | 1 |
| Masuda, Y | 2 |
| Suzuki, M | 1 |
| Akagawa, Y | 1 |
| Takemura, T | 1 |
| Suzuki, Y | 3 |
| Okaya, Y | 2 |
| Nishimatsu, H | 2 |
| Aisaka, K | 3 |
| Rudner, XL | 1 |
| Berkowitz, DE | 1 |
| Booth, JV | 1 |
| Funk, BL | 1 |
| Cozart, KL | 1 |
| D'Amico, EB | 1 |
| El-Moalem, H | 1 |
| Page, SO | 1 |
| Richardson, CD | 1 |
| Winters, B | 1 |
| Marucci, L | 1 |
| Schwinn, DA | 1 |
| Kanada, A | 1 |
| Ahmed, H | 1 |
| Fukasawa, R | 1 |
| Kitamura, T | 1 |
| Tatemichi, S | 1 |
| Akiyama, K | 1 |
| Iwase, M | 1 |
| Sandler, S | 1 |
| Carlsson, PO | 1 |
| Hellerström, C | 1 |
| Jansson, L | 1 |
| Abete, P | 1 |
| Testa, G | 1 |
| Ferrara, N | 1 |
| De Santis, D | 1 |
| Capaccio, P | 1 |
| Viati, L | 1 |
| Calabrese, C | 1 |
| Cacciatore, F | 1 |
| Longobardi, G | 1 |
| Condorelli, M | 1 |
| Napoli, C | 1 |
| Rengo, F | 1 |
| Charuel, C | 1 |
| Comby, P | 1 |
| Monro, AM | 1 |
| Rossolini, G | 1 |
| Viticchi, C | 1 |
| Basso, A | 1 |
| Zaia, A | 1 |
| Piantanelli, L | 1 |
| Atkinson, BN | 1 |
| Minneman, KP | 1 |
| Kimball, KA | 1 |
| Cornett, LE | 1 |
| Seifen, E | 1 |
| Kennedy, RH | 1 |
| Borst, SE | 3 |
| Narang, N | 1 |
| Crews, FT | 1 |
| Scarpace, PJ | 3 |
| Christ, GJ | 1 |
| Maayani, S | 1 |
| Valcic, M | 1 |
| Melman, A | 1 |
| Jagadeesh, G | 1 |
| Tian, WN | 1 |
| Gupta, S | 1 |
| Deth, RC | 1 |
| Johnson, MD | 1 |
| Wray, A | 1 |
| Miyamoto, A | 2 |
| Araiso, T | 1 |
| Koyama, T | 1 |
| Ohshika, H | 2 |
| Wagerle, LC | 1 |
| Kurth, CD | 1 |
| Roth, RA | 1 |
| Latifpour, J | 1 |
| Kondo, S | 1 |
| O'Hollaren, B | 1 |
| Morita, T | 1 |
| Weiss, RM | 1 |
| Mollace, V | 1 |
| Pelaggi, T | 1 |
| Nisticò, G | 1 |
| McNeil, JJ | 1 |
| Drummer, OH | 1 |
| Conway, EL | 1 |
| Workman, BS | 1 |
| Louis, WJ | 1 |
| Brunello, N | 1 |
| Riva, M | 1 |
| Rovescalli, AC | 1 |
| Galimberti, R | 1 |
| Racagni, G | 1 |
| Schoeffter, P | 1 |
| Godfraind, T | 1 |
| Ishikawa, Y | 1 |
| Gee, MV | 2 |
| Baum, BJ | 2 |
| Kitamura, Y | 1 |
| Zhao, XH | 1 |
| Ohnuki, T | 1 |
| Nomura, Y | 1 |
| Shinkai, M | 1 |
| Yamasawa, K | 1 |
| Rooney, TA | 1 |
| Nahorski, SR | 1 |
| Tsujimoto, G | 2 |
| Hashimoto, K | 2 |
| Lange, R | 1 |
| Hermsdorf, T | 1 |
| Dettmer, D | 1 |
| Hofmann, E | 1 |
| Nowak, G | 2 |
| Silberring, J | 1 |
| Kuyatt, BL | 1 |
| Helman, Y | 1 |
| Elliott, HL | 1 |
| Meredith, PA | 1 |
| Vincent, J | 1 |
| Maeda, O | 2 |
| Walters, DE | 1 |
| Carr, LA | 1 |
| Hård, E | 1 |
| Engel, J | 1 |
| Lindh, AS | 1 |
| Sennello, LT | 1 |
| Sonders, RC | 1 |
| Glassman, HN | 1 |
| Jordan, DC | 1 |
| Luther, RR | 1 |
| Tolman, KG | 1 |
| Zicha, J | 1 |
| Kunes, J | 1 |
| Lébl, M | 1 |
| Pohlová, I | 1 |
| Jelínek, J | 1 |
| Lynch, CJ | 1 |
| Charest, R | 1 |
| Arnsten, AF | 1 |
| Goldman-Rakic, PS | 1 |
| Tsujimoto, A | 1 |
| Kato, K | 1 |
| Slotkin, TA | 1 |
| Kavlock, RJ | 1 |
| Cowdery, T | 1 |
| Orband, L | 1 |
| Bartolome, M | 1 |
| Whitmore, WL | 1 |
| Bartolome, J | 1 |
| Docherty, JR | 2 |
| Hyland, L | 2 |
| Ishizuka, M | 1 |
| Mogilnicka, E | 1 |
| Klimek, V | 1 |
| Hanna, MK | 1 |
| Khairallah, PA | 1 |
| Warnock, P | 1 |
| Sebban, C | 1 |
| Tesolin, B | 1 |
| Shvaloff, A | 1 |
| Le Roch, K | 1 |
| Berthaux, P | 1 |
| Toda, N | 1 |
| Shimizu, I | 1 |
2 reviews available for prazosin and Aging
| Article | Year |
|---|---|
The role of alpha 1-blockade in benign prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Aging; Clinical Trials as Topic; Humans; Male; Phenoxybenzamine; Prazo | 1993 |
Insulin resistance and hypertension in the elderly. Optimal drug therapy.
Topics: Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diuretics; Glucose; | 1994 |
4 trials available for prazosin and Aging
| Article | Year |
|---|---|
The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Biological Availability; Blood | 1996 |
Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aging; Blood Pressure Monitoring, Ambulatory; | 1998 |
Effect of age on pharmacokinetics of and blood pressure responses to prazosin and terazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Aging; Blood Pressure; Humans; Kinetics; Middle Aged; Prazosin; | 1987 |
Effect of age on the pharmacokinetics of orally and intravenously administered terazosin.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Creatinine; Female; Humans; | 1988 |
93 other studies available for prazosin and Aging
| Article | Year |
|---|---|
Angiocrine signals regulate quiescence and therapy resistance in bone metastasis.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Antineoplastic Agents; Bone Marrow; Bone Ne | 2019 |
Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Apoptosis; Brain; Cyclin D1; Dioxanes; Fema | 2014 |
Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling.
Topics: Aging; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Central Nervous System Depressants; | 2015 |
Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Blotting, Western; Fluoresc | 2008 |
ATP overflow in skeletal muscle 1A arterioles.
Topics: Action Potentials; Adenosine Triphosphate; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 | 2010 |
Effects of chronic exposure to radiofrequency electromagnetic fields on energy balance in developing rats.
Topics: Aging; Animals; Body Temperature Regulation; Electromagnetic Fields; Feeding Behavior; Male; Prazosi | 2013 |
Age-related peculiarities of the effect of alpha-adrenoreceptor blockade on cardiac function in rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Bradycardia; Electric Stimulation; Heart Rate; Prazosi | 2002 |
Anseculin improves passive avoidance learning of aged mice.
Topics: Aging; Analysis of Variance; Animals; Avoidance Learning; Benzopyrans; Binding Sites; Dose-Response | 2003 |
Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals | 2004 |
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Aging; Analysis of Variance; A | 2005 |
Alpha 1 adrenergic receptor control of renal blood vessels during aging.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Down-Regulation; Male; Microcirculation; Muscle Contra | 2005 |
Changes in purinergic signalling in developing and ageing rat tail artery: importance for temperature control.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonis | 2006 |
Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Dose-Respo | 2006 |
Impaired recovery of alpha 1- and alpha 2-adrenergic receptors in brain tissue of aged rats.
Topics: Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Hypothalamus; Male; Phenoxybenzamine; Prazo | 1984 |
Changes in brain alpha-adrenoceptors with increasing age in rabbits.
Topics: Aging; Animals; Blood Pressure; Brain; Clonidine; Male; Prazosin; Rabbits; Receptors, Adrenergic, al | 1984 |
The older patient with hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Benzothiadiazines; Blood Pressure; Blood Pressure Determin | 1980 |
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In | 1980 |
Hypertension: special concerns in geriatric patients.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Calcium Channel Blockers; Captopril; Diet, Sodium-Restrict | 1984 |
Effect of neonatal 6-hydroxydopamine treatment on alpha 1- and alpha 2-adrenoceptors in rat cerebral cortex.
Topics: Aging; Animals; Animals, Newborn; Brain; Clonidine; Female; Hydroxydopamines; Kinetics; Prazosin; Pr | 1982 |
Ontogeny of alpha 1 and alpha 2-adrenoceptors in rat brain.
Topics: Aging; Animals; Brain; Clonidine; Female; Male; Norepinephrine; Prazosin; Rats; Receptors, Adrenergi | 1980 |
Effects of prazosin on the cAMP system in the spontaneously hypertensive rat (SHR) aorta.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Aorta; Blood Pressure; Cycli | 1980 |
Ontogeny of myocardial alpha 1-adrenergic receptor in the rat.
Topics: Aging; Animals; Animals, Newborn; Dihydroalprenolol; Heart; Myocardium; Organ Size; Prazosin; Rats; | 1981 |
Loss of rat ventricular alpha 1-adrenergic receptors during aging.
Topics: Aging; Animals; Heart; Heart Ventricles; Male; Myocardium; Prazosin; Rats; Rats, Inbred Strains; Rec | 1982 |
Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats.
Topics: Aging; Animals; Cyclic AMP; Epinephrine; Isoproterenol; Liver; Male; Prazosin; Propranolol; Rats; Ra | 1983 |
Normal ontogeny of alpha 1-adrenergic receptor in rat liver is thyroid hormone dependent.
Topics: Aging; Animals; Binding, Competitive; Cell Membrane; Female; Hypothyroidism; Kinetics; Liver; Male; | 1983 |
Renal aging change of alpha 1-adrenoceptor in Wistar rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Autoradiography; Binding Sites; Clonidine; Kidney; Kin | 1995 |
6-Hydroxydopamine treatment of neonatal rats. I. Effects on the development of the spinal cord noradrenergic system.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Cyclic AMP; Dihydroalprenolol; In Vit | 1993 |
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine; | 1995 |
Changes in neuronal contribution to contractile responses of vas deferens of young and adult guinea pigs.
Topics: Adenosine Triphosphate; Aging; Animals; Electric Stimulation; Guinea Pigs; Hypogastric Plexus; Male; | 1994 |
Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat.
Topics: Adrenergic alpha-Antagonists; Aging; Alkylating Agents; Animals; Binding, Competitive; Clonidine; Di | 1993 |
Effects of maturation on alpha-adrenergic receptor affinity and occupancy in small cerebral arteries.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Cerebral Arter | 1994 |
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.
Topics: Aging; Animals; Azepines; Biogenic Amines; Brain; Cataplexy; Chromosome Mapping; Crosses, Genetic; D | 1993 |
Alpha 1-adrenoceptor antagonist decreases alpha 2-adrenoceptor antagonist-induced high voltage spindle suppression in adult and aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Electroencephalography; Imi | 1993 |
Age-related alterations in receptor density and metabolic activity in the brain.
Topics: Aging; Animals; Brain; Choline O-Acetyltransferase; Down-Regulation; Glycolysis; Male; Oxygen Consum | 1993 |
Age-related changes of noradrenergic-NPY interaction in rat brain: norepinephrine, NPY levels and alpha-adrenoceptors.
Topics: Aging; Animals; Brain Stem; Hypothalamus; Male; Neuropeptide Y; Norepinephrine; Prazosin; Rats; Rats | 1993 |
Alpha 1-adrenergic and muscarinic receptors in adult and neonatal rat type II pneumocytes.
Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium Channels; Lung; Male; Prazosin; Pulmonary Alveoli | 1993 |
Changes in alpha 1-adrenoceptor coupling to Ca2+ channels during development in rat heart.
Topics: Aging; Animals; Animals, Newborn; Calcium Channels; Electric Conductivity; Heart; Membrane Potential | 1994 |
Preweanling administration of terazosin decreases blood pressure of hypertensive rats in adulthood.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Suckling; Blood Pressure; Drug Administration | 1996 |
Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aging; Angiotensin II; Animals; Ant | 1996 |
Age-related changes in alpha-adrenoceptor-mediated blood pressure in the rat: relationship between the potency for phenylephrine and the maximum number of binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta | 1996 |
Effects of aging and food restriction on alpha 1-adrenergic receptors and G-protein in the rat parotid gland.
Topics: Aging; Animals; Binding, Competitive; Body Weight; Cell Membrane; Eating; Epinephrine; Food Deprivat | 1997 |
High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries.
Topics: Acclimatization; Adrenergic alpha-Antagonists; Aging; Altitude; Animals; Cerebral Arteries; Female; | 1997 |
Alpha 1-adrenoceptor vasoconstriction in the tail artery during ageing.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1997 |
[Cardial output in rats of various ages during blocking of alpha1- and beta-adrenoreceptors].
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; | 1999 |
Developmental and pharmacological features of mouse emotional piloerection.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Behavior, Animal; Conditioning, Classical; Diazepam; E | 1999 |
Age-related change of the role of alpha1L-adrenoceptor in canine urethral smooth muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Aging; Animals; Autoradiograp | 1999 |
Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Aorta; Arteries; Celiac | 1999 |
The role of alpha 1L-adrenoceptor in rat urinary bladder: comparison between young adult and aged rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Cresols; In Vitro Technique | 1999 |
Contractile properties of urethral smooth muscles of young and aged female dogs: morphological and pharmacological aspects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Autoradiography; Dogs; Fema | 2000 |
The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production.
Topics: Adrenergic alpha-Antagonists; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihyperten | 2001 |
Subchronic treatment with prazosin improves passive avoidance learning in aged mice: possible relationships to alpha1-receptor up-regulation.
Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Avoidance Learning; Brain; Cell | 2000 |
Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Aging; Animals; Blood Flow Velocity; Bod | 2002 |
Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half-life: interplay of age and diurnal feeding pattern.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Do | 1992 |
Thymus-induced recovery of age-related decrease of brain cortex alpha- and beta-adrenoceptors.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Cerebral Cortex; Clonidine; Dihydroalprenolol; | 1991 |
Multiple adrenergic receptor subtypes controlling cyclic AMP formation: comparison of brain slices and primary neuronal and glial cultures.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Colfo | 1991 |
Aging: changes in cardiac alpha 1-adrenoceptor responsiveness and expression.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Binding Sites; Blotting, Northern; Cardiotonic Agents; He | 1991 |
Reduced alpha 1-adrenergic receptor-mediated inositide hydrolysis in cardiac atria of senescent rats.
Topics: Aging; Animals; Epinephrine; Female; Heart Atria; Hydrolysis; In Vitro Techniques; Inosine Nucleotid | 1990 |
Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Reduced high-affinity alpha 1-adrenoceptors in liver of senescent rats: implications of assessment at various temperatures.
Topics: Aging; Animals; Binding, Competitive; Female; In Vitro Techniques; Kinetics; Liver; Naphazoline; Pra | 1990 |
Alpha 1-adrenergic stimulation of inositide hydrolysis in liver of senescent rats.
Topics: Aging; Animals; Epinephrine; Female; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Phosphatidyli | 1990 |
Developmental changes in alpha 1-adrenoceptor coupling to G-protein in bovine aorta.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Aorta, Thoracic; Binding, Competitive; Cattle; Cold Tempe | 1990 |
Alpha 1 adrenergic receptor function in senescent Fischer 344 rat aorta.
Topics: Aging; Animals; Aorta; Calcium; Inositol Phosphates; Male; Norepinephrine; Prazosin; Rats; Rats, Inb | 1990 |
Membrane viscosity correlates with alpha 1-adrenergic signal transduction of the aged rat cerebral cortex.
Topics: Aging; Animals; Cerebral Cortex; Cholesterol; Inositol Phosphates; Male; Membrane Fluidity; Norepine | 1990 |
Sympathetic reactivity of cerebral arteries in developing fetal lamb and adult sheep.
Topics: Aging; Animals; Animals, Newborn; Arterioles; Cerebral Arteries; Cocaine; Electric Stimulation; Fetu | 1990 |
Autonomic receptors in urinary tract: sex and age differences.
Topics: Aging; Animals; Binding Sites; Binding, Competitive; Dihydroalprenolol; Female; Male; Muscle, Smooth | 1990 |
The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats.
Topics: Aging; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; M | 1990 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami | 1988 |
Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors.
Topics: Adult; Aged; Aging; Aspirin; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Female; Histamine; H | 1989 |
Decreased signal transduction in rat parotid cell aggregates during aging is not due to loss of alpha 1-adrenergic receptors.
Topics: Aging; Animals; Cell Aggregation; Cell Membrane; Epinephrine; Male; Parotid Gland; Prazosin; Rats; R | 1989 |
Ligand-binding characteristics of [3H]QNB, [3H]prazosin, [3H]rauwolscine, [3H]TCP and [3H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse.
Topics: Aging; Animals; Cerebral Cortex; Hippocampus; Male; Mice; Prazosin; Quinuclidines; Quinuclidinyl Ben | 1989 |
Age-related changes in [3H]prazosin binding and phosphoinositide hydrolysis in rat ventricular myocardium.
Topics: Aging; Animals; Cholesterol; Heart; Hydrolysis; Male; Membranes; Myocardium; Norepinephrine; Phospha | 1989 |
Effects of aging on alpha 1-adrenoceptor mechanisms and the inhibitory effect of diltiazem on noradrenaline maximum response in isolated rat aortic preparation.
Topics: Aging; Animals; Aorta, Thoracic; Diltiazem; In Vitro Techniques; Male; Muscle Contraction; Muscle, S | 1989 |
Postnatal ontogeny of agonist and depolarization-induced phosphoinositide hydrolysis in rat cerebral cortex.
Topics: Aging; Animals; Arecoline; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Hydrolysis; Male; N | 1987 |
Effects of triiodo-L-thyronine (T3)-induced hyperthyroidism on the cardiovascular alpha-adrenoceptor system in young and older rats.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cardiovascular System | 1987 |
Developmental changes of the alpha-1-adrenergic receptor system in rat liver.
Topics: Aging; Animals; Binding, Competitive; Blood Glucose; Calcimycin; Gluconeogenesis; Glucose; Guanylyl | 1987 |
Kinetics of [3H]-prazosin binding to the rat cortex during aging.
Topics: Aging; Animals; Cerebral Cortex; Male; Phentolamine; Phenylephrine; Prazosin; Rats; Rats, Inbred Str | 1988 |
Alpha 1-adrenergic responsiveness of young adult and aged rat submandibular cells in vitro.
Topics: Aging; Animals; Calcium; Epinephrine; Kinetics; Male; Prazosin; Rats; Rats, Inbred Strains; Receptor | 1985 |
Clinical pharmacological studies with doxazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aging; Antihypertensive Agents; Blood Pressure; Doxazosin | 1986 |
Postsynaptic alpha 1-adrenoceptor mechanisms in rat vas deferens and ageing.
Topics: Aging; Animals; In Vitro Techniques; Kinetics; Male; Microsomes; Muscle Contraction; Muscle, Smooth; | 1987 |
Perinatal exposure to cannabinoids alters neurochemical development in rat brain.
Topics: Aging; Animals; Brain; Brain Chemistry; Cannabinoids; Catecholamines; Corpus Striatum; Dronabinol; F | 1988 |
Effect of clonidine on ultrasonic vocalization in preweaning rats.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Body Temperature; Clonidine; Dioxanes; Dose-Response R | 1988 |
Haemodynamics and the participation of pressor systems in young and adult rats with age-dependent DOCA-salt hypertension.
Topics: Aging; Animals; Blood Pressure; Captopril; Desoxycorticosterone; Hemodynamics; Hypertension; Male; P | 1987 |
Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age.
Topics: Aging; Animals; Calcium; Cell Membrane; Cold Temperature; Egtazic Acid; Glucagon; Guanine Nucleotide | 1985 |
Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates.
Topics: Aging; Animals; Cerebral Cortex; Clonidine; Cognition; Female; Hydroxydopamines; Macaca mulatta; Mem | 1985 |
Developmental alteration in adrenergic regulation of hepatic glycogen phosphorylase.
Topics: Aging; Animals; Cyclic AMP; Epinephrine; In Vitro Techniques; Isoproterenol; Liver; Liver Glycogen; | 1986 |
Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat.
Topics: Aging; Animals; Animals, Newborn; Binding Sites; Female; Heart; Kidney; Liver; Lung; Male; Methylmer | 1986 |
Alpha-adrenoceptor responsiveness in the aged rat.
Topics: Aging; Anesthesia; Animals; Blood Pressure; Cocaine; Decerebrate State; Ethanolamines; Heart Rate; M | 1986 |
A difference in alpha-adrenoceptor mechanisms in vasa deferentia isolated from young and old rats.
Topics: Aging; Animals; In Vitro Techniques; Male; Norepinephrine; Phenoxybenzamine; Prazosin; Rats; Rats, I | 1986 |
Age-dependent day/night variations of alpha 1- and beta-adrenoceptors in the rat cerebral cortex.
Topics: Aging; Animals; Cerebral Cortex; Circadian Rhythm; Dihydroalprenolol; Exploratory Behavior; Male; Pr | 1986 |
Alterations of myocardial alpha 1-adrenergic receptors in hypertensive cardiac hypertrophy in the rat.
Topics: Aging; Animals; Blood Pressure; Cardiomegaly; Hypertension; Hypertension, Renal; Male; Myocardium; O | 1986 |
Age-related alterations in alpha 1- and beta-adrenoceptors mediated responsiveness of rat aorta.
Topics: Aging; Animals; Aorta, Thoracic; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vasc | 1987 |
Age-related variation of EEG responses to clonidine, prazosin and yohimbine in rats.
Topics: Aging; Animals; Brain; Clonidine; Electroencephalography; Electrophysiology; Prazosin; Rats; Yohimbi | 1987 |
Neuroeffector function in mesenteric arteries isolated from beagles of different ages.
Topics: Aging; Angiotensin II; Animals; Dogs; Female; Male; Mesenteric Arteries; Muscle Contraction; Norepin | 1987 |