Page last updated: 2024-11-03

prazosin and Aging

prazosin has been researched along with Aging in 99 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats."7.69Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996)
" The Cmax was identical in the two groups, and the time to Cmax was 84 min in the elderly and 114 min in the young subjects."6.68The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin. ( Andros, E; Detmar-Hanna, D; Gal, J; Gerber, JG; Suteparuk, S, 1996)
"The effects of aging on alpha(1)-adrenoceptor (alpha(1)-AR)-mediated contractile response in endothelium-removed aortic preparations isolated from 5- to 40-week-old (5-, 6-, 8-, 10-, 20-, 40-weeks) mice were studied in the presence of propranolol."3.73Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation. ( Funabiki, M; Koike, K; Michikawa, H; Tanaka, Y, 2006)
"Blockade of alpha(1)-adrenoreceptors with prazosin produces bradycardia."3.71Age-related peculiarities of the effect of alpha-adrenoreceptor blockade on cardiac function in rats. ( Zefirov, AL; Zefirov, TL; Ziyatdinova, NI, 2002)
"To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats."3.69Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996)
"To study the effects of aging on the blood pressure potency of phenylephrine, 6-, 10- and 40-week-old rats were used."3.69Age-related changes in alpha-adrenoceptor-mediated blood pressure in the rat: relationship between the potency for phenylephrine and the maximum number of binding sites. ( Kanai, S; Koike, K; Ohtsuki, H; Satoh, M; Takayanagi, I, 1996)
" To test the hypothesis that hypoxia-induced developmental and vessel specific cerebral artery contractility changes are mediated, in part, by changes in alpha1-adrenergic receptor (alpha1-AR) density and/or NE-induced inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] responses, we performed the following study."3.69High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries. ( Longo, LD; Ueno, N; Zhang, L; Zhao, Y, 1997)
" We investigated, using rats at 2, 12 and 24 months of age, the effect of aging on ventricular alpha 1-adrenoceptor responsiveness by measuring the [3H]prazosin binding, [3H]inositol phosphate formation, the cholesterol/phospholipid ratio and membrane viscosity."3.67Age-related changes in [3H]prazosin binding and phosphoinositide hydrolysis in rat ventricular myocardium. ( Miyamoto, A; Ohshika, H, 1989)
"nilvadipine or terazosin was administered for 2 weeks in a randomized crossover manner."2.69Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke. ( Abe, I; Fujishima, M; Hasuo, Y; Nishino, Y; Onaka, U; Setoguchi, M, 1998)
"Prazosin and terazosin are two alpha 1-adrenoceptor blocking agents, their principal difference being the longer half-life of terazosin."2.66Effect of age on pharmacokinetics of and blood pressure responses to prazosin and terazosin. ( Conway, EL; Drummer, OH; Louis, WJ; McNeil, JJ; Workman, BS, 1987)
" For both routes of administration, the only pharmacokinetic variables significantly correlated with age were terminal elimination rate constant and the area under the plasma concentration-time curve (AUC)."2.66Effect of age on the pharmacokinetics of orally and intravenously administered terazosin. ( Glassman, HN; Jordan, DC; Luther, RR; Sennello, LT; Sonders, RC; Tolman, KG, 1988)
" Next, we determined norepinephrine dose-response relations before and after prazosin, yohimbine, and benextramine."1.29Effects of maturation on alpha-adrenergic receptor affinity and occupancy in small cerebral arteries. ( Elliott, SR; Pearce, WJ, 1994)
"Narcolepsy is a genetically determined disorder of sleep characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep that affects both humans and animals."1.29Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. ( Arrigoni, J; Ciaranello, RD; Dement, WC; Edgar, DM; Mignot, E; Nishino, S; Reid, MS; Sharp, LH; Siegel, JM, 1993)
"1."1.28Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. ( Christ, GJ; Maayani, S; Melman, A; Valcic, M, 1990)
"[3H]Prazosin binding was typical of an alpha 1-adrenergic receptor, and (-)epinephrine affinity for the [3H]prazosin-binding sites was not altered in the presence of 10(-5) M guanylyl-imidodiphosphate."1.27Normal ontogeny of alpha 1-adrenergic receptor in rat liver is thyroid hormone dependent. ( Noguchi, A, 1983)
" In young subjects the mean bioavailability was 65% and the mean terminal elimination half-lives were 9."1.27Clinical pharmacological studies with doxazosin. ( Elliott, HL; Meredith, PA; Reid, JL; Vincent, J, 1986)
" 258, 5103-5109) but did not affect the dose-response curves for norepinephrine-induced Ca2+ mobilization and phosphorylase activation in these cells."1.27Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age. ( Blackmore, PF; Charest, R; Exton, JH; Lynch, CJ, 1985)

Research

Studies (99)

TimeframeStudies, this research(%)All Research%
pre-199041 (41.41)18.7374
1990's41 (41.41)18.2507
2000's12 (12.12)29.6817
2010's5 (5.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Singh, A1
Veeriah, V1
Xi, P1
Labella, R1
Chen, J1
Romeo, SG1
Ramasamy, SK1
Kusumbe, AP1
Coccurello, R1
Bielawski, A1
Zelek-Molik, A1
Vetulani, J1
Kowalska, M1
D'Amato, FR1
Nalepa, I1
Skelly, MJ1
Chappell, AE1
Carter, E1
Weiner, JL1
Dmitrieva, N1
Zhang, G1
Nagabukuro, H1
Kluess, HA1
Stone, AJ1
Evanson, KW1
Pelletier, A1
Delanaud, S1
Décima, P1
Thuroczy, G1
de Seze, R1
Cerri, M1
Bach, V1
Libert, JP1
Loos, N1
Ziyatdinova, NI1
Zefirov, AL1
Zefirov, TL1
Knauber, J2
Müller, WE2
Collier, TJ1
Greene, JG1
Felten, DL1
Stevens, SY1
Collier, KS1
Moore, TL1
Schettler, SP1
Killiany, RJ1
Herndon, JG1
Luebke, JI1
Moss, MB1
Rosene, DL1
Passmore, JC1
Rowell, PP1
Joshua, IG1
Porter, JP1
Patel, DH1
Falcone, JC1
Wallace, A1
Knight, GE1
Cowen, T1
Burnstock, G1
Tanaka, Y2
Funabiki, M1
Michikawa, H1
Koike, K4
Zhou, LW1
Weiss, B1
Freilich, JS1
Greenberg, LH1
Hamilton, CA1
Howe, CA1
Reid, JL2
Prinsley, DM1
Harris, A1
Swamy, VC1
Triggle, DJ1
Waters, DH1
Pulliam, JP1
McCarron, DA1
Dausse, JP2
Le Quan-Bui, KH1
Meyer, P2
Morris, MJ1
Devynck, MA1
D'Armiento, M1
Lacerna, F1
Lauro, R1
Modesti, A1
Verna, R1
Ceccarelli, G1
Noguchi, A2
Whitsett, JA1
Dickman, L1
Partilla, JS1
Hoopes, MT1
Ito, H1
Dax, EM1
Roth, GS3
Morgan, NG1
Blackmore, PF2
Exton, JH2
Moriyama, N4
Kurimoto, S1
Inagaki, O1
Takanashi, M1
Hamada, K1
Kawabe, K3
Simmons, KE1
Jones, DJ1
Brawer, MK1
Tanaka, H1
Manita, S1
Matsuda, T1
Adachi, M1
Shigenobu, K1
Nagao, T1
Fujita, A1
Takeuchi, T1
Hata, F1
Gascón, S1
Dierssen, M1
Màrmol, F1
Vivas, NM2
Badia, A1
Elliott, SR1
Pearce, WJ1
Paolisso, G1
Gambardella, A1
Galzerano, D1
Varricchio, M1
Mignot, E1
Nishino, S1
Sharp, LH1
Arrigoni, J1
Siegel, JM1
Reid, MS1
Edgar, DM1
Ciaranello, RD1
Dement, WC1
Riekkinen, P2
Sirviö, J1
Toivanen, L1
Riekkinen, M1
Lammintausta, R1
Azuma, H1
Huguet, F1
Comoy, E1
Piriou, A1
Bohuon, C1
Keeney, SE1
Oelberg, DG1
Liu, QY1
Karpinski, E1
Pang, PK1
McCarty, R1
Lee, JH1
Andros, E1
Detmar-Hanna, D1
Suteparuk, S1
Gal, J1
Gerber, JG1
Davidow, LW1
Buñag, RD1
Satoh, M1
Kanai, S1
Ohtsuki, H1
Takayanagi, I4
Chen, C1
Noland, KA1
Kalu, DN1
Ueno, N1
Zhao, Y1
Zhang, L1
Longo, LD1
Vila, E1
Tabernero, A1
Giraldo, J1
Arribas, SM1
Setoguchi, M1
Onaka, U1
Abe, I1
Hasuo, Y1
Nishino, Y1
Fujishima, M1
Nigmatullina, RR1
Abzalov, RA1
Minnibaev, ESh1
Masuda, Y2
Suzuki, M1
Akagawa, Y1
Takemura, T1
Suzuki, Y3
Okaya, Y2
Nishimatsu, H2
Aisaka, K3
Rudner, XL1
Berkowitz, DE1
Booth, JV1
Funk, BL1
Cozart, KL1
D'Amico, EB1
El-Moalem, H1
Page, SO1
Richardson, CD1
Winters, B1
Marucci, L1
Schwinn, DA1
Kanada, A1
Ahmed, H1
Fukasawa, R1
Kitamura, T1
Tatemichi, S1
Akiyama, K1
Iwase, M1
Sandler, S1
Carlsson, PO1
Hellerström, C1
Jansson, L1
Abete, P1
Testa, G1
Ferrara, N1
De Santis, D1
Capaccio, P1
Viati, L1
Calabrese, C1
Cacciatore, F1
Longobardi, G1
Condorelli, M1
Napoli, C1
Rengo, F1
Charuel, C1
Comby, P1
Monro, AM1
Rossolini, G1
Viticchi, C1
Basso, A1
Zaia, A1
Piantanelli, L1
Atkinson, BN1
Minneman, KP1
Kimball, KA1
Cornett, LE1
Seifen, E1
Kennedy, RH1
Borst, SE3
Narang, N1
Crews, FT1
Scarpace, PJ3
Christ, GJ1
Maayani, S1
Valcic, M1
Melman, A1
Jagadeesh, G1
Tian, WN1
Gupta, S1
Deth, RC1
Johnson, MD1
Wray, A1
Miyamoto, A2
Araiso, T1
Koyama, T1
Ohshika, H2
Wagerle, LC1
Kurth, CD1
Roth, RA1
Latifpour, J1
Kondo, S1
O'Hollaren, B1
Morita, T1
Weiss, RM1
Mollace, V1
Pelaggi, T1
Nisticò, G1
McNeil, JJ1
Drummer, OH1
Conway, EL1
Workman, BS1
Louis, WJ1
Brunello, N1
Riva, M1
Rovescalli, AC1
Galimberti, R1
Racagni, G1
Schoeffter, P1
Godfraind, T1
Ishikawa, Y1
Gee, MV2
Baum, BJ2
Kitamura, Y1
Zhao, XH1
Ohnuki, T1
Nomura, Y1
Shinkai, M1
Yamasawa, K1
Rooney, TA1
Nahorski, SR1
Tsujimoto, G2
Hashimoto, K2
Lange, R1
Hermsdorf, T1
Dettmer, D1
Hofmann, E1
Nowak, G2
Silberring, J1
Kuyatt, BL1
Helman, Y1
Elliott, HL1
Meredith, PA1
Vincent, J1
Maeda, O2
Walters, DE1
Carr, LA1
Hård, E1
Engel, J1
Lindh, AS1
Sennello, LT1
Sonders, RC1
Glassman, HN1
Jordan, DC1
Luther, RR1
Tolman, KG1
Zicha, J1
Kunes, J1
Lébl, M1
Pohlová, I1
Jelínek, J1
Lynch, CJ1
Charest, R1
Arnsten, AF1
Goldman-Rakic, PS1
Tsujimoto, A1
Kato, K1
Slotkin, TA1
Kavlock, RJ1
Cowdery, T1
Orband, L1
Bartolome, M1
Whitmore, WL1
Bartolome, J1
Docherty, JR2
Hyland, L2
Ishizuka, M1
Mogilnicka, E1
Klimek, V1
Hanna, MK1
Khairallah, PA1
Warnock, P1
Sebban, C1
Tesolin, B1
Shvaloff, A1
Le Roch, K1
Berthaux, P1
Toda, N1
Shimizu, I1

Reviews

2 reviews available for prazosin and Aging

ArticleYear
The role of alpha 1-blockade in benign prostatic hyperplasia.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:9

    Topics: Adrenergic alpha-Antagonists; Aging; Clinical Trials as Topic; Humans; Male; Phenoxybenzamine; Prazo

1993
Insulin resistance and hypertension in the elderly. Optimal drug therapy.
    Drugs & aging, 1994, Volume: 4, Issue:5

    Topics: Aged; Aging; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diuretics; Glucose;

1994

Trials

4 trials available for prazosin and Aging

ArticleYear
The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin.
    European journal of clinical pharmacology, 1996, Volume: 50, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Biological Availability; Blood

1996
Comparative efficacies of a calcium antagonist and an alpha1 blocker in elderly hypertensive patients with stroke.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1998, Volume: 20, Issue:7

    Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aging; Blood Pressure Monitoring, Ambulatory;

1998
Effect of age on pharmacokinetics of and blood pressure responses to prazosin and terazosin.
    Journal of cardiovascular pharmacology, 1987, Volume: 10, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aging; Blood Pressure; Humans; Kinetics; Middle Aged; Prazosin;

1987
Effect of age on the pharmacokinetics of orally and intravenously administered terazosin.
    Clinical therapeutics, 1988, Volume: 10, Issue:5

    Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Creatinine; Female; Humans;

1988

Other Studies

93 other studies available for prazosin and Aging

ArticleYear
Angiocrine signals regulate quiescence and therapy resistance in bone metastasis.
    JCI insight, 2019, 07-11, Volume: 4, Issue:13

    Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Antineoplastic Agents; Bone Marrow; Bone Ne

2019
Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Jan-03, Volume: 48

    Topics: Adrenergic alpha-1 Receptor Antagonists; Aging; Animals; Apoptosis; Brain; Cyclin D1; Dioxanes; Fema

2014
Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling.
    Neuropharmacology, 2015, Volume: 97

    Topics: Aging; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Central Nervous System Depressants;

2015
Increased alpha1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats.
    World journal of urology, 2008, Volume: 26, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Blotting, Western; Fluoresc

2008
ATP overflow in skeletal muscle 1A arterioles.
    The Journal of physiology, 2010, Aug-15, Volume: 588, Issue:Pt 16

    Topics: Action Potentials; Adenosine Triphosphate; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1

2010
Effects of chronic exposure to radiofrequency electromagnetic fields on energy balance in developing rats.
    Environmental science and pollution research international, 2013, Volume: 20, Issue:5

    Topics: Aging; Animals; Body Temperature Regulation; Electromagnetic Fields; Feeding Behavior; Male; Prazosi

2013
Age-related peculiarities of the effect of alpha-adrenoreceptor blockade on cardiac function in rats.
    Bulletin of experimental biology and medicine, 2002, Volume: 133, Issue:6

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Bradycardia; Electric Stimulation; Heart Rate; Prazosi

2002
Anseculin improves passive avoidance learning of aged mice.
    Pharmacological research, 2003, Volume: 47, Issue:3

    Topics: Aging; Analysis of Variance; Animals; Avoidance Learning; Benzopyrans; Binding Sites; Dose-Response

2003
Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats.
    Neurobiology of aging, 2004, Volume: 25, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals

2004
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.
    Behavioural brain research, 2005, May-28, Volume: 160, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Aging; Analysis of Variance; A

2005
Alpha 1 adrenergic receptor control of renal blood vessels during aging.
    Canadian journal of physiology and pharmacology, 2005, Volume: 83, Issue:4

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Down-Regulation; Male; Microcirculation; Muscle Contra

2005
Changes in purinergic signalling in developing and ageing rat tail artery: importance for temperature control.
    Neuropharmacology, 2006, Volume: 50, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonis

2006
Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2006, Volume: 42, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Aorta, Thoracic; Dose-Respo

2006
Impaired recovery of alpha 1- and alpha 2-adrenergic receptors in brain tissue of aged rats.
    Journal of gerontology, 1984, Volume: 39, Issue:5

    Topics: Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Hypothalamus; Male; Phenoxybenzamine; Prazo

1984
Changes in brain alpha-adrenoceptors with increasing age in rabbits.
    Brain research, 1984, Nov-19, Volume: 322, Issue:1

    Topics: Aging; Animals; Blood Pressure; Brain; Clonidine; Male; Prazosin; Rabbits; Receptors, Adrenergic, al

1984
The older patient with hypertension.
    Australian family physician, 1980, Volume: 9, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Aging; Benzothiadiazines; Blood Pressure; Blood Pressure Determin

1980
Responses to noradrenaline of portal vein strips from normotensive and spontaneously hypertensive rats.
    Journal of autonomic pharmacology, 1980, Volume: 1, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Blood Pressure; Dioxanes; Gallopamil; Hypertension; In

1980
Hypertension: special concerns in geriatric patients.
    Geriatrics, 1984, Volume: 39, Issue:8

    Topics: Adrenergic beta-Antagonists; Aged; Aging; Calcium Channel Blockers; Captopril; Diet, Sodium-Restrict

1984
Effect of neonatal 6-hydroxydopamine treatment on alpha 1- and alpha 2-adrenoceptors in rat cerebral cortex.
    Journal of cardiovascular pharmacology, 1982, Volume: 4 Suppl 1

    Topics: Aging; Animals; Animals, Newborn; Brain; Clonidine; Female; Hydroxydopamines; Kinetics; Prazosin; Pr

1982
Ontogeny of alpha 1 and alpha 2-adrenoceptors in rat brain.
    Brain research, 1980, May-19, Volume: 190, Issue:1

    Topics: Aging; Animals; Brain; Clonidine; Female; Male; Norepinephrine; Prazosin; Rats; Receptors, Adrenergi

1980
Effects of prazosin on the cAMP system in the spontaneously hypertensive rat (SHR) aorta.
    European journal of pharmacology, 1980, Jul-25, Volume: 65, Issue:2-3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Aorta; Blood Pressure; Cycli

1980
Ontogeny of myocardial alpha 1-adrenergic receptor in the rat.
    Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Dihydroalprenolol; Heart; Myocardium; Organ Size; Prazosin; Rats;

1981
Loss of rat ventricular alpha 1-adrenergic receptors during aging.
    Life sciences, 1982, Nov-29, Volume: 31, Issue:22

    Topics: Aging; Animals; Heart; Heart Ventricles; Male; Myocardium; Prazosin; Rats; Rats, Inbred Strains; Rec

1982
Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats.
    The Journal of biological chemistry, 1983, Apr-25, Volume: 258, Issue:8

    Topics: Aging; Animals; Cyclic AMP; Epinephrine; Isoproterenol; Liver; Male; Prazosin; Propranolol; Rats; Ra

1983
Normal ontogeny of alpha 1-adrenergic receptor in rat liver is thyroid hormone dependent.
    Endocrinology, 1983, Volume: 113, Issue:2

    Topics: Aging; Animals; Binding, Competitive; Cell Membrane; Female; Hypothyroidism; Kinetics; Liver; Male;

1983
Renal aging change of alpha 1-adrenoceptor in Wistar rats.
    General pharmacology, 1995, Volume: 26, Issue:2

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Autoradiography; Binding Sites; Clonidine; Kidney; Kin

1995
6-Hydroxydopamine treatment of neonatal rats. I. Effects on the development of the spinal cord noradrenergic system.
    Brain research, 1993, May-21, Volume: 611, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Cyclic AMP; Dihydroalprenolol; In Vit

1993
Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate.
    British journal of pharmacology, 1995, Volume: 114, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Atropine;

1995
Changes in neuronal contribution to contractile responses of vas deferens of young and adult guinea pigs.
    Journal of the autonomic nervous system, 1994, Dec-01, Volume: 50, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Electric Stimulation; Guinea Pigs; Hypogastric Plexus; Male;

1994
Effects of age on alpha 1-adrenoceptor subtypes in the heart ventricular muscle of the rat.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:10

    Topics: Adrenergic alpha-Antagonists; Aging; Alkylating Agents; Animals; Binding, Competitive; Clonidine; Di

1993
Effects of maturation on alpha-adrenergic receptor affinity and occupancy in small cerebral arteries.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Cerebral Arter

1994
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:3

    Topics: Aging; Animals; Azepines; Biogenic Amines; Brain; Cataplexy; Chromosome Mapping; Crosses, Genetic; D

1993
Alpha 1-adrenoceptor antagonist decreases alpha 2-adrenoceptor antagonist-induced high voltage spindle suppression in adult and aged rats.
    European journal of pharmacology, 1993, Apr-28, Volume: 235, Issue:2-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Electroencephalography; Imi

1993
Age-related alterations in receptor density and metabolic activity in the brain.
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1993, Volume: 13, Issue:3

    Topics: Aging; Animals; Brain; Choline O-Acetyltransferase; Down-Regulation; Glycolysis; Male; Oxygen Consum

1993
Age-related changes of noradrenergic-NPY interaction in rat brain: norepinephrine, NPY levels and alpha-adrenoceptors.
    Brain research, 1993, Oct-22, Volume: 625, Issue:2

    Topics: Aging; Animals; Brain Stem; Hypothalamus; Male; Neuropeptide Y; Norepinephrine; Prazosin; Rats; Rats

1993
Alpha 1-adrenergic and muscarinic receptors in adult and neonatal rat type II pneumocytes.
    Lung, 1993, Volume: 171, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium Channels; Lung; Male; Prazosin; Pulmonary Alveoli

1993
Changes in alpha 1-adrenoceptor coupling to Ca2+ channels during development in rat heart.
    FEBS letters, 1994, Jan-31, Volume: 338, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Calcium Channels; Electric Conductivity; Heart; Membrane Potential

1994
Preweanling administration of terazosin decreases blood pressure of hypertensive rats in adulthood.
    Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Animals, Suckling; Blood Pressure; Drug Administration

1996
Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aging; Angiotensin II; Animals; Ant

1996
Age-related changes in alpha-adrenoceptor-mediated blood pressure in the rat: relationship between the potency for phenylephrine and the maximum number of binding sites.
    Pharmacology, 1996, Volume: 52, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Aorta

1996
Effects of aging and food restriction on alpha 1-adrenergic receptors and G-protein in the rat parotid gland.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1997, Volume: 52, Issue:2

    Topics: Aging; Animals; Binding, Competitive; Body Weight; Cell Membrane; Eating; Epinephrine; Food Deprivat

1997
High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries.
    The American journal of physiology, 1997, Volume: 272, Issue:2 Pt 2

    Topics: Acclimatization; Adrenergic alpha-Antagonists; Aging; Altitude; Animals; Cerebral Arteries; Female;

1997
Alpha 1-adrenoceptor vasoconstriction in the tail artery during ageing.
    British journal of pharmacology, 1997, Volume: 121, Issue:5

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon

1997
[Cardial output in rats of various ages during blocking of alpha1- and beta-adrenoreceptors].
    Biulleten' eksperimental'noi biologii i meditsiny, 1999, Volume: 127, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists;

1999
Developmental and pharmacological features of mouse emotional piloerection.
    Experimental animals, 1999, Volume: 48, Issue:3

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Behavior, Animal; Conditioning, Classical; Diazepam; E

1999
Age-related change of the role of alpha1L-adrenoceptor in canine urethral smooth muscle.
    General pharmacology, 1999, Volume: 33, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Aging; Animals; Autoradiograp

1999
Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.
    Circulation, 1999, Dec-07, Volume: 100, Issue:23

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Aorta; Arteries; Celiac

1999
The role of alpha 1L-adrenoceptor in rat urinary bladder: comparison between young adult and aged rats.
    Life sciences, 1999, Volume: 65, Issue:24

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Cresols; In Vitro Technique

1999
Contractile properties of urethral smooth muscles of young and aged female dogs: morphological and pharmacological aspects.
    International journal of urology : official journal of the Japanese Urological Association, 2000, Volume: 7, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Autoradiography; Dogs; Fema

2000
The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production.
    European journal of endocrinology, 2001, Volume: 144, Issue:2

    Topics: Adrenergic alpha-Antagonists; Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihyperten

2001
Subchronic treatment with prazosin improves passive avoidance learning in aged mice: possible relationships to alpha1-receptor up-regulation.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:12

    Topics: Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Avoidance Learning; Brain; Cell

2000
Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Aging; Animals; Blood Flow Velocity; Bod

2002
Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half-life: interplay of age and diurnal feeding pattern.
    Journal of applied toxicology : JAT, 1992, Volume: 12, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Do

1992
Thymus-induced recovery of age-related decrease of brain cortex alpha- and beta-adrenoceptors.
    The International journal of neuroscience, 1991, Volume: 59, Issue:1-3

    Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Cerebral Cortex; Clonidine; Dihydroalprenolol;

1991
Multiple adrenergic receptor subtypes controlling cyclic AMP formation: comparison of brain slices and primary neuronal and glial cultures.
    Journal of neurochemistry, 1991, Volume: 56, Issue:2

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Colfo

1991
Aging: changes in cardiac alpha 1-adrenoceptor responsiveness and expression.
    European journal of pharmacology, 1991, Nov-13, Volume: 208, Issue:3

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Binding Sites; Blotting, Northern; Cardiotonic Agents; He

1991
Reduced alpha 1-adrenergic receptor-mediated inositide hydrolysis in cardiac atria of senescent rats.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:3

    Topics: Aging; Animals; Epinephrine; Female; Heart Atria; Hydrolysis; In Vitro Techniques; Inosine Nucleotid

1990
Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues.
    British journal of pharmacology, 1990, Volume: 101, Issue:2

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1990
Reduced high-affinity alpha 1-adrenoceptors in liver of senescent rats: implications of assessment at various temperatures.
    British journal of pharmacology, 1990, Volume: 101, Issue:3

    Topics: Aging; Animals; Binding, Competitive; Female; In Vitro Techniques; Kinetics; Liver; Naphazoline; Pra

1990
Alpha 1-adrenergic stimulation of inositide hydrolysis in liver of senescent rats.
    Mechanisms of ageing and development, 1990, Volume: 56, Issue:3

    Topics: Aging; Animals; Epinephrine; Female; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Phosphatidyli

1990
Developmental changes in alpha 1-adrenoceptor coupling to G-protein in bovine aorta.
    European journal of pharmacology, 1990, Jul-31, Volume: 189, Issue:1

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Aorta, Thoracic; Binding, Competitive; Cattle; Cold Tempe

1990
Alpha 1 adrenergic receptor function in senescent Fischer 344 rat aorta.
    Life sciences, 1990, Volume: 46, Issue:5

    Topics: Aging; Animals; Aorta; Calcium; Inositol Phosphates; Male; Norepinephrine; Prazosin; Rats; Rats, Inb

1990
Membrane viscosity correlates with alpha 1-adrenergic signal transduction of the aged rat cerebral cortex.
    Journal of neurochemistry, 1990, Volume: 55, Issue:1

    Topics: Aging; Animals; Cerebral Cortex; Cholesterol; Inositol Phosphates; Male; Membrane Fluidity; Norepine

1990
Sympathetic reactivity of cerebral arteries in developing fetal lamb and adult sheep.
    The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 2

    Topics: Aging; Animals; Animals, Newborn; Arterioles; Cerebral Arteries; Cocaine; Electric Stimulation; Fetu

1990
Autonomic receptors in urinary tract: sex and age differences.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:2

    Topics: Aging; Animals; Binding Sites; Binding, Competitive; Dihydroalprenolol; Female; Male; Muscle, Smooth

1990
The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats.
    British journal of pharmacology, 1990, Volume: 100, Issue:3

    Topics: Aging; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; M

1990
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:3

    Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami

1988
Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors.
    Experientia, 1989, May-15, Volume: 45, Issue:5

    Topics: Adult; Aged; Aging; Aspirin; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Female; Histamine; H

1989
Decreased signal transduction in rat parotid cell aggregates during aging is not due to loss of alpha 1-adrenergic receptors.
    Experimental gerontology, 1989, Volume: 24, Issue:1

    Topics: Aging; Animals; Cell Aggregation; Cell Membrane; Epinephrine; Male; Parotid Gland; Prazosin; Rats; R

1989
Ligand-binding characteristics of [3H]QNB, [3H]prazosin, [3H]rauwolscine, [3H]TCP and [3H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse.
    Neuroscience letters, 1989, Dec-04, Volume: 106, Issue:3

    Topics: Aging; Animals; Cerebral Cortex; Hippocampus; Male; Mice; Prazosin; Quinuclidines; Quinuclidinyl Ben

1989
Age-related changes in [3H]prazosin binding and phosphoinositide hydrolysis in rat ventricular myocardium.
    General pharmacology, 1989, Volume: 20, Issue:5

    Topics: Aging; Animals; Cholesterol; Heart; Hydrolysis; Male; Membranes; Myocardium; Norepinephrine; Phospha

1989
Effects of aging on alpha 1-adrenoceptor mechanisms and the inhibitory effect of diltiazem on noradrenaline maximum response in isolated rat aortic preparation.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:11

    Topics: Aging; Animals; Aorta, Thoracic; Diltiazem; In Vitro Techniques; Male; Muscle Contraction; Muscle, S

1989
Postnatal ontogeny of agonist and depolarization-induced phosphoinositide hydrolysis in rat cerebral cortex.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Aging; Animals; Arecoline; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Hydrolysis; Male; N

1987
Effects of triiodo-L-thyronine (T3)-induced hyperthyroidism on the cardiovascular alpha-adrenoceptor system in young and older rats.
    Japanese journal of pharmacology, 1987, Volume: 44, Issue:4

    Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cardiovascular System

1987
Developmental changes of the alpha-1-adrenergic receptor system in rat liver.
    Biomedica biochimica acta, 1987, Volume: 46, Issue:11

    Topics: Aging; Animals; Binding, Competitive; Blood Glucose; Calcimycin; Gluconeogenesis; Glucose; Guanylyl

1987
Kinetics of [3H]-prazosin binding to the rat cortex during aging.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; Male; Phentolamine; Phenylephrine; Prazosin; Rats; Rats, Inbred Str

1988
Alpha 1-adrenergic responsiveness of young adult and aged rat submandibular cells in vitro.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1985, Volume: 81, Issue:1

    Topics: Aging; Animals; Calcium; Epinephrine; Kinetics; Male; Prazosin; Rats; Rats, Inbred Strains; Receptor

1985
Clinical pharmacological studies with doxazosin.
    British journal of clinical pharmacology, 1986, Volume: 21 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aging; Antihypertensive Agents; Blood Pressure; Doxazosin

1986
Postsynaptic alpha 1-adrenoceptor mechanisms in rat vas deferens and ageing.
    The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:9

    Topics: Aging; Animals; In Vitro Techniques; Kinetics; Male; Microsomes; Muscle Contraction; Muscle, Smooth;

1987
Perinatal exposure to cannabinoids alters neurochemical development in rat brain.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:1

    Topics: Aging; Animals; Brain; Brain Chemistry; Cannabinoids; Catecholamines; Corpus Striatum; Dronabinol; F

1988
Effect of clonidine on ultrasonic vocalization in preweaning rats.
    Journal of neural transmission, 1988, Volume: 73, Issue:3

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Body Temperature; Clonidine; Dioxanes; Dose-Response R

1988
Haemodynamics and the participation of pressor systems in young and adult rats with age-dependent DOCA-salt hypertension.
    Physiologia Bohemoslovaca, 1987, Volume: 36, Issue:1

    Topics: Aging; Animals; Blood Pressure; Captopril; Desoxycorticosterone; Hemodynamics; Hypertension; Male; P

1987
Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age.
    The Journal of biological chemistry, 1985, Feb-10, Volume: 260, Issue:3

    Topics: Aging; Animals; Calcium; Cell Membrane; Cold Temperature; Egtazic Acid; Glucagon; Guanine Nucleotide

1985
Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates.
    Science (New York, N.Y.), 1985, Dec-13, Volume: 230, Issue:4731

    Topics: Aging; Animals; Cerebral Cortex; Clonidine; Cognition; Female; Hydroxydopamines; Macaca mulatta; Mem

1985
Developmental alteration in adrenergic regulation of hepatic glycogen phosphorylase.
    Japanese journal of pharmacology, 1986, Volume: 40, Issue:1

    Topics: Aging; Animals; Cyclic AMP; Epinephrine; In Vitro Techniques; Isoproterenol; Liver; Liver Glycogen;

1986
Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat.
    Toxicology, 1986, Volume: 41, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Binding Sites; Female; Heart; Kidney; Liver; Lung; Male; Methylmer

1986
Alpha-adrenoceptor responsiveness in the aged rat.
    European journal of pharmacology, 1986, Jul-15, Volume: 126, Issue:1-2

    Topics: Aging; Anesthesia; Animals; Blood Pressure; Cocaine; Decerebrate State; Ethanolamines; Heart Rate; M

1986
A difference in alpha-adrenoceptor mechanisms in vasa deferentia isolated from young and old rats.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:4

    Topics: Aging; Animals; In Vitro Techniques; Male; Norepinephrine; Phenoxybenzamine; Prazosin; Rats; Rats, I

1986
Age-dependent day/night variations of alpha 1- and beta-adrenoceptors in the rat cerebral cortex.
    Physiology & behavior, 1986, Volume: 38, Issue:1

    Topics: Aging; Animals; Cerebral Cortex; Circadian Rhythm; Dihydroalprenolol; Exploratory Behavior; Male; Pr

1986
Alterations of myocardial alpha 1-adrenergic receptors in hypertensive cardiac hypertrophy in the rat.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 283, Issue:1

    Topics: Aging; Animals; Blood Pressure; Cardiomegaly; Hypertension; Hypertension, Renal; Male; Myocardium; O

1986
Age-related alterations in alpha 1- and beta-adrenoceptors mediated responsiveness of rat aorta.
    Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 335, Issue:1

    Topics: Aging; Animals; Aorta, Thoracic; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vasc

1987
Age-related variation of EEG responses to clonidine, prazosin and yohimbine in rats.
    Medical biology, 1987, Volume: 65, Issue:5-6

    Topics: Aging; Animals; Brain; Clonidine; Electroencephalography; Electrophysiology; Prazosin; Rats; Yohimbi

1987
Neuroeffector function in mesenteric arteries isolated from beagles of different ages.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1

    Topics: Aging; Angiotensin II; Animals; Dogs; Female; Male; Mesenteric Arteries; Muscle Contraction; Norepin

1987