prazosin has been researched along with Aggression in 8 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prazosin was well tolerated and improved behavioral symptoms in patients with agitation/aggression in AD." | 9.14 | Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. ( Hart, KL; Hoff, DJ; McFall, YH; Peskind, ER; Raskind, MA; Rohde, K; Shofer, JB; Wang, LY, 2009) |
| "Prazosin was well tolerated and improved behavioral symptoms in patients with agitation/aggression in AD." | 5.14 | Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. ( Hart, KL; Hoff, DJ; McFall, YH; Peskind, ER; Raskind, MA; Rohde, K; Shofer, JB; Wang, LY, 2009) |
| "Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder precipitated by exposure to extreme traumatic stress." | 1.37 | The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder. ( Defino, MC; Hague, C; Olson, VG; Peskind, ER; Raskind, MA; Redila, VA; Reh, RK; Rockett, HR; Szot, P; Tran, PM; Venkov, HA, 2011) |
| "Tianeptine (TIA) is an antidepressant drug which enhances the reuptake of serotonin but, in contrast to tricyclics, shows no affinity for neurotransmitter receptors." | 1.31 | Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system. ( Dlaboga, D; Dziedzicka-Wasylewska, M; Maj, J; Rogóz, Z; Skuza, G, 2001) |
| "Mirtazapine (MIR) is an antidepressant which enhances noradrenergic and serotonergic 5-HT1A neurotransmission via antagomism of central alpha2-adrenergic autoreceptors and heteroreceptors." | 1.31 | Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors. ( Dlaboga, D; Dziedzicka-Wasylewska, M; Maj, J; Rogoz, Z; Wrobel, A, 2002) |
| "Desipramine-induced increase in aggressive behavior was blocked by phentolamine (3 mg/kg, IP) and yohimbine (0." | 1.28 | Desipramine enhances isolation-induced aggressive behavior in mice. ( Cai, B; Matsumoto, K; Ohta, H; Satoh, T; Watanabe, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, LY | 1 |
| Shofer, JB | 1 |
| Rohde, K | 1 |
| Hart, KL | 1 |
| Hoff, DJ | 1 |
| McFall, YH | 1 |
| Raskind, MA | 2 |
| Peskind, ER | 2 |
| Olson, VG | 1 |
| Rockett, HR | 1 |
| Reh, RK | 1 |
| Redila, VA | 1 |
| Tran, PM | 1 |
| Venkov, HA | 1 |
| Defino, MC | 1 |
| Hague, C | 1 |
| Szot, P | 1 |
| Sharp, SI | 1 |
| Ballard, CG | 1 |
| Chen, CP | 1 |
| Francis, PT | 1 |
| Cai, B | 2 |
| Matsumoto, K | 2 |
| Ohta, H | 2 |
| Watanabe, H | 2 |
| Rogóz, Z | 2 |
| Skuza, G | 1 |
| Dlaboga, D | 2 |
| Maj, J | 2 |
| Dziedzicka-Wasylewska, M | 2 |
| Wrobel, A | 1 |
| Satoh, T | 1 |
| Fujiwara, Y | 1 |
| Takeda, T | 1 |
| Kazahaya, Y | 1 |
| Otsuki, S | 1 |
| Sandyk, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Alzheimer's in Long-Term Care--Treatment for Agitation[NCT00161473] | 24 participants (Actual) | Interventional | 2001-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Brief Psychiatric Rating Scale (BPRS) is an 18-item scale that rates psychiatric symptoms. Each item ranges from 1 to 7. Therefore, the Brief Psychiatric Rating Scale total score ranges from a minimum of 0 to a maximum of 126, where 126 indicates higher levels of behavioral symptoms.~A change Brief Psychiatric Rating Scale score that is a negative number (that is, a Brief Psychiatric Rating Scale score decrease), indicates behavioral improvement." (NCT00161473)
Timeframe: Weeks 2, 4, 6, and 8 (change from Baseline)
| Intervention | units on a scale (Mean) |
|---|---|
| Prazosin | -9 |
| Placebo | -3 |
"The Neuropsychiatric Inventory (NPI) is a 12-item scale that assesses the frequency and severity of behavioral symptoms in patients with dementia. Each Neuropsychiatric Inventory item ranges from 0 to 12. Therefore the Neuropsychiatric Inventory total score has a minimum total value of 0 and maximum 144, where 144 indicates higher levels of behavioral symptoms.~A change in Neuropsychiatric Inventory total score that is a negative number (that is, an Neuropsychiatric Inventory score decrease), indicates behavioral improvement." (NCT00161473)
Timeframe: Weeks 2, 4, 6, and 8 (change from Baseline)
| Intervention | units on a scale (Mean) |
|---|---|
| Prazosin | -19 |
| Placebo | -2 |
"The Clinical Global Impression of Change (CGIC) is a 7 point scale, where 1 indicates markedly improved, 4 indicates no change, and 7 indicates markedly worse." (NCT00161473)
Timeframe: Week 8
| Intervention | units on a scale (Mean) |
|---|---|
| Prazosin | 2.6 |
| Placebo | 4.5 |
This measure reflects the length of time participants remained in the study. There were 6 behavioral assessment visits included in the protocol. (NCT00161473)
Timeframe: Last behavioral assessment (Baseline, Weeks 1, 2, 4, 6, or 8)
| Intervention | number of visits (Mean) |
|---|---|
| Prazosin | 4.8 |
| Placebo | 4.5 |
1 trial available for prazosin and Aggression
| Article | Year |
|---|---|
Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Behavioral Sym | 2009 |
7 other studies available for prazosin and Aggression
| Article | Year |
|---|---|
The role of norepinephrine in differential response to stress in an animal model of posttraumatic stress disorder.
Topics: Acoustic Stimulation; Aggression; Animals; Brain Mapping; Clonidine; Disease Models, Animal; Electri | 2011 |
Aggressive behavior and neuroleptic medication are associated with increased number of alpha1-adrenoceptors in patients with Alzheimer disease.
Topics: Aggression; Alzheimer Disease; Antipsychotic Agents; Binding Sites; Cell Count; Cerebellum; Frontal | 2007 |
Biphasic effects of typical antidepressants and mianserin, an atypical antidepressant, on aggressive behavior in socially isolated mice.
Topics: Aggression; Amitriptyline; Animals; Antidepressive Agents; Brain Chemistry; Clomipramine; Male; Mapr | 1993 |
Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aggression; Animals; Binding, Competitive; | 2001 |
Effect of repeated treatment with mirtazapine on the central alpha1-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aggression; Animals; Antidepressive Agents, | 2002 |
Desipramine enhances isolation-induced aggressive behavior in mice.
Topics: Aggression; Animals; Clonidine; Desipramine; Imipramine; Male; Mice; Mice, Inbred Strains; Motor Act | 1991 |
Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in mice.
Topics: Adenosine; Aggression; Animals; Behavior, Animal; Caffeine; Carbamazepine; Clonidine; Haloperidol; M | 1988 |