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prazosin and ANS (Autonomic Nervous System) Diseases

prazosin has been researched along with ANS (Autonomic Nervous System) Diseases in 12 studies

Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.

Research Excerpts

ExcerptRelevanceReference
"Prazosin was well tolerated and did not produce a significant lowering of resting blood pressure."2.67A study of the alpha-1 adrenoceptor blocker prazosin in the prophylactic management of autonomic dysreflexia in high spinal cord injury patients. ( Brown, DJ; Howes, LG; Krum, H; Louis, WJ, 1992)
"Treatment with hydralazine at hypotensive dose for 12 weeks also failed to affect the proteinuria in 5 of 6 nephrectomized CKD rats."1.40Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats. ( Ayajiki, K; Funai, A; Kobuchi, S; Matsumura, Y; Ohkita, M; Suzuki, R; Tanaka, R; Tsutsui, H; Yazawa, M, 2014)
"The mechanism of autonomic hyperreflexia has been thought to be an acute general autonomic overactivity in response to cutaneous or visceral stimuli, but it remains uncertain."1.30[Induction of noradrenergic supersensitivity following cordotomy in neonatal rat spinal motoneurons]. ( Kadotani, H, 1999)
"Terazosin was evaluated in 21 normotensive spinal cord injured patients with autonomic dysreflexia."1.29Prospective evaluation of terazosin for the treatment of autonomic dysreflexia. ( Chancellor, MB; Erhard, MJ; Hirsch, IH; Stass, WE, 1994)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19902 (16.67)18.7374
1990's7 (58.33)18.2507
2000's2 (16.67)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kobuchi, S1
Tanaka, R1
Funai, A1
Suzuki, R1
Yazawa, M1
Tsutsui, H1
Ohkita, M1
Ayajiki, K1
Matsumura, Y1
Osborn, JW2
Collister, JP1
Guzman, P1
Santajuliana, D1
Zukowska-Grojec, Z1
Rivas, DA1
Chancellor, MB2
Huang, B1
Salzman, SK1
Erhard, MJ1
Hirsch, IH1
Stass, WE1
Murray, A1
Pearson, GT1
Cottrell, DF1
Vaidyanathan, S1
Soni, BM1
Sett, P1
Watt, JW1
Oo, T1
Bingley, J1
Kadotani, H1
Gallego, M1
Casis, E1
Izquierdo, MJ1
Casis, O1
Krum, H1
Louis, WJ1
Brown, DJ1
Howes, LG1
Rochette, G1
Lecomte, J1
Onrot, J1
Goldberg, MR1
Biaggioni, I1
Hollister, AS1
Kincaid, D1
Robertson, D1

Trials

2 trials available for prazosin and ANS (Autonomic Nervous System) Diseases

ArticleYear
Pathophysiology of autonomic dysreflexia: long-term treatment with terazosin in adult and paediatric spinal cord injury patients manifesting recurrent dysreflexic episodes.
    Spinal cord, 1998, Volume: 36, Issue:11

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Autonomic Nervous System Diseases; Child; Dose-Resp

1998
A study of the alpha-1 adrenoceptor blocker prazosin in the prophylactic management of autonomic dysreflexia in high spinal cord injury patients.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1992, Volume: 2, Issue:2

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Autonomic Nervous System Diseases; Blood Pressure;

1992

Other Studies

10 other studies available for prazosin and ANS (Autonomic Nervous System) Diseases

ArticleYear
Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats.
    Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Autonom

2014
Effect of peripheral sympathetic nerve dysfunction on salt sensitivity of arterial pressure.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:3

    Topics: Animals; Antihypertensive Agents; Autonomic Nervous System Diseases; Blood Pressure; Dose-Response R

2008
Contribution of alpha- and beta- adrenoceptors and neuropeptide-Y to autonomic dysreflexia.
    Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 1995, Volume: 5, Issue:2

    Topics: Animals; Autonomic Nervous System Diseases; Blood Pressure; Ganglionic Blockers; Heart Rate; Hexamet

1995
Autonomic dysreflexia in a rat model spinal cord injury and the effect of pharmacologic agents.
    Neurourology and urodynamics, 1995, Volume: 14, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System Diseases; Calcium Channel Blockers;

1995
Prospective evaluation of terazosin for the treatment of autonomic dysreflexia.
    The Journal of urology, 1994, Volume: 151, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Autonomic Nervous System Diseases; Humans; Male; Middle Aged; Praz

1994
In vitro responses to noradrenaline of small intestine taken from normal and grass sickness-affected horses.
    Veterinary research communications, 1997, Volume: 21, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System Diseases;

1997
[Induction of noradrenergic supersensitivity following cordotomy in neonatal rat spinal motoneurons].
    Nihon Ika Daigaku zasshi, 1999, Volume: 66, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Autonomic Nervou

1999
Restoration of cardiac transient outward potassium current by norepinephrine in diabetic rats.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 441, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autonomic Nervous System Disease

2000
[Several cardiovascular manifestations induced by vibrational stimuli].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1985, Volume: 179, Issue:4

    Topics: Adult; Autonomic Nervous System Diseases; Cardiovascular Diseases; Fingers; Humans; Hypertension; Me

1985
Postjunctional vascular smooth muscle alpha-2 adrenoreceptors in human autonomic failure.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1987, Volume: 10, Issue:1

    Topics: Aged; Autonomic Nervous System Diseases; Blood Platelets; Blood Pressure; Clonidine; Dose-Response R

1987