Page last updated: 2024-11-03

praziquantel and Seizures

praziquantel has been researched along with Seizures in 25 studies

azinox: Russian drug

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Children with persistent neurocysticercosis were randomized into 3 groups-albendazole (n = 19), albendazole and praziquantel (n = 21), and placebo (n = 20)-for 30 days and followed up at 3 and 6 months for resolution and recurrence of seizures."9.51Efficacy of Combination Therapy of Albendazole and Praziquantel vs Albendazole Monotherapy in Children With Persistent Neurocysticercosis: A Randomized Controlled Trial. ( Khandelwal, N; Saini, AG; Singh, K; Singhi, P, 2022)
"To evaluate the efficacy and safety of a combination of albendazole and praziquantel in children with seizures and single small enhancing computerized tomographic lesions."9.14Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial. ( Kaur, S; Khandelwal, N; Singhi, P; Singhi, S, 2009)
"55%; P = 0."6.43Meta-analysis: Cysticidal drugs for neurocysticercosis: albendazole and praziquantel. ( Coffey, CS; Del Brutto, OH; García, HH; Roos, KL, 2006)
"Children with persistent neurocysticercosis were randomized into 3 groups-albendazole (n = 19), albendazole and praziquantel (n = 21), and placebo (n = 20)-for 30 days and followed up at 3 and 6 months for resolution and recurrence of seizures."5.51Efficacy of Combination Therapy of Albendazole and Praziquantel vs Albendazole Monotherapy in Children With Persistent Neurocysticercosis: A Randomized Controlled Trial. ( Khandelwal, N; Saini, AG; Singh, K; Singhi, P, 2022)
"To evaluate the efficacy and safety of a combination of albendazole and praziquantel in children with seizures and single small enhancing computerized tomographic lesions."5.14Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial. ( Kaur, S; Khandelwal, N; Singhi, P; Singhi, S, 2009)
"Plasma praziquantel concentrations were measured in 11 Thai patients with active neurocysticercosis (8 males and 3 females)."5.08Plasma concentrations of praziquantel during the therapy of neurocysticerosis with praziquantel, in the presence of antiepileptics and dexamethasone. ( Karbwang, J; Na-Bangchang, K; Vanijanonta, S, 1995)
"Anthelminthic treatment with albendazole provides improved rates of seizure freedom and hastens resolution of the granuloma."4.89Drug therapy for solitary cysticercus granuloma: a systematic review and meta-analysis. ( Otte, WM; Sander, JW; Singh, G; Singla, M, 2013)
"Cyst resolution was unsatisfactory with albendazole monotherapy but was very high when it was followed by a combination of albendazole and praziquantel."4.31Efficacy and safety of antiparasitic therapy for neurocysticercosis in rural Tanzania: a prospective cohort study. ( Bottieau, E; Carabin, H; Dorny, P; Fleury, A; Gabriël, S; Jackson, E; Magnussen, P; Makasi, C; Mwape, KE; Ngowi, BJ; Prazeres da Costa, C; Prodjinotho, UF; Ruether, C; Schmidt, V; Stelzle, D; Trevisan, C; Van Damme, I; Winkler, AS; Zulu, G, 2023)
" Lastly, widespread neurocysticercosis may be a concern in mass treatment programs that provide praziquantel (for managing schistosomiasis) or albendazole (for managing intestinal worms or lymphatic filariasis) because these drugs may kill cerebral cysticerci, resulting in severe adverse events."3.74Could neurocysticercosis be the cause of "onchocerciasis-associated" epileptic seizures? ( Eberhard, M; Habumogisha, P; Katabarwa, M; Lakwo, T; Richards, F, 2008)
"Neurocysticercosis is a parasitic infection of the central nervous system by the larval stage of the pork tapeworm and is a common cause of seizures and epilepsy in endemic areas."2.72Anthelmintics for people with neurocysticercosis. ( Abba, K; Monk, EJM; Ranganathan, LN, 2021)
"55%; P = 0."2.43Meta-analysis: Cysticidal drugs for neurocysticercosis: albendazole and praziquantel. ( Coffey, CS; Del Brutto, OH; García, HH; Roos, KL, 2006)
"Praziquantel was not used."2.37Intraparenchymal cerebral cysticercosis in children: diagnosis and treatment. ( Crawford, TO; Mitchell, WG, 1988)
"When she presented with further seizures 6 months later, attempts to arrange neuroimaging and specialist assessment were unsuccessful owing to restrictions on routine healthcare services during the SARS-CoV-2 nationwide lockdown."1.62Hydatid brain cyst: A delayed diagnosis in a rural setting during COVID-19. ( Brink, AJ; Da Fonseca, SP; Enslin, JMN; Nuttall, J; Opperman, CJ; Tootla, HD, 2021)
"Neurocysticercosis is an unusual cause of seizure in the New Zealand setting."1.38Neurocysticercosis: an unusual cause of seizure in the New Zealand setting. ( Heron, P; Pybus, M, 2012)
"In Japan neurocysticercosis is a rare disease."1.31[A case of neurocysticercosis presenting as focal seizure]. ( Higuchi, H; Kobayashi, N; Okada, T; Sugiyama, M; Teramoto, A; Yabe, Y, 2000)
"After medical treatment of neurocysticercosis, there is usually remission or marked improvement in the associated seizure disorder."1.28The course of seizures after treatment for cerebral cysticercosis. ( Sotelo, J; Vazquez, V, 1992)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.00)18.7374
1990's4 (16.00)18.2507
2000's7 (28.00)29.6817
2010's6 (24.00)24.3611
2020's5 (20.00)2.80

Authors

AuthorsStudies
Opperman, CJ1
Enslin, JMN1
Nuttall, J1
Brink, AJ1
Da Fonseca, SP1
Tootla, HD1
Singh, K1
Saini, AG1
Khandelwal, N2
Singhi, P2
Stelzle, D1
Makasi, C1
Schmidt, V1
Trevisan, C1
Van Damme, I1
Ruether, C1
Dorny, P1
Magnussen, P1
Zulu, G1
Mwape, KE1
Bottieau, E1
Prazeres da Costa, C1
Prodjinotho, UF1
Carabin, H1
Jackson, E1
Fleury, A1
Gabriël, S1
Ngowi, BJ1
Winkler, AS1
Landzberg, DR1
Dhir, A1
Jillella, DV1
Monk, EJM1
Abba, K1
Ranganathan, LN1
Garcia, HH2
Del Brutto, OH3
Kaur, S1
Singhi, S1
George, J1
Rose, D1
Hazrati, LN1
Majl, L1
Hodaie, M1
Hewagama, SS1
Darby, JD1
Sheorey, H1
Daffy, JR1
Pybus, M1
Heron, P1
Takayanagui, OM1
Odashima, NS1
Bonato, PS1
Lima, JE1
Lanchote, VL1
Otte, WM1
Singla, M1
Sander, JW2
Singh, G2
Narula, G1
Bawa, KS1
Roos, KL1
Coffey, CS1
Katabarwa, M1
Lakwo, T1
Habumogisha, P1
Richards, F1
Eberhard, M1
Hayashi, M1
Matsuda, H1
Tormis, LC1
Nosenas, JS1
Blas, BL1
Shandera, WX1
White, AC1
Chen, JC1
Diaz, P1
Armstrong, R1
Na-Bangchang, K1
Vanijanonta, S1
Karbwang, J1
Buitrago, M1
Edwards, B1
Rosner, F1
Sugiyama, M1
Okada, T1
Higuchi, H1
Yabe, Y1
Kobayashi, N1
Teramoto, A1
Vazquez, V1
Sotelo, J1
Mitchell, WG1
Crawford, TO1
Rosenthal, RE1
Emsellem, HA1
Kline, PP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Characteristics of Patients With Symptomatic Active Neurocysticercosis and Effect of Treatment on Symptoms, Lesions and Quality of Life in Resource-poor Rural Areas of Eastern Africa - TOPANA, a Multi-centre Prospective Cohort Study.[NCT03834337]63 participants (Actual)Observational2019-04-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for praziquantel and Seizures

ArticleYear
Anthelmintics for people with neurocysticercosis.
    The Cochrane database of systematic reviews, 2021, 06-01, Volume: 6

    Topics: Adult; Albendazole; Anticestodal Agents; Bias; Brain Diseases; Child; Humans; Neurocysticercosis; Pl

2021
Antiparasitic treatment of neurocysticercosis - The effect of cyst destruction in seizure evolution.
    Epilepsy & behavior : E&B, 2017, Volume: 76

    Topics: Albendazole; Anticestodal Agents; Antiparasitic Agents; Brain; Cysts; Epilepsy; Female; Humans; Infl

2017
Medical management of neurocysticercosis.
    Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:18

    Topics: Albendazole; Animals; Anthelmintics; Brain Diseases; Humans; Life Cycle Stages; Magnetic Resonance I

2011
Drug therapy for solitary cysticercus granuloma: a systematic review and meta-analysis.
    Neurology, 2013, Jan-08, Volume: 80, Issue:2

    Topics: Adolescent; Albendazole; Anthelmintics; Anti-Inflammatory Agents; Calcinosis; Child; Child, Preschoo

2013
Neurocysticercosis--New Millennium, ancient disease and unending debate.
    Indian journal of pediatrics, 2003, Volume: 70, Issue:4

    Topics: Albendazole; Animals; Anthelmintics; Anticonvulsants; Humans; Neurocysticercosis; Praziquantel; Seiz

2003
Meta-analysis: Cysticidal drugs for neurocysticercosis: albendazole and praziquantel.
    Annals of internal medicine, 2006, Jul-04, Volume: 145, Issue:1

    Topics: Albendazole; Anthelmintics; Humans; Neurocysticercosis; Praziquantel; Radiography; Secondary Prevent

2006
Intraparenchymal cerebral cysticercosis in children: diagnosis and treatment.
    Pediatrics, 1988, Volume: 82, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Animals; Black People; Brain Diseases; Calcinosis; Carbamazepine;

1988

Trials

3 trials available for praziquantel and Seizures

ArticleYear
Efficacy of Combination Therapy of Albendazole and Praziquantel vs Albendazole Monotherapy in Children With Persistent Neurocysticercosis: A Randomized Controlled Trial.
    Journal of child neurology, 2022, Volume: 37, Issue:5

    Topics: Adolescent; Albendazole; Anthelmintics; Child; Child, Preschool; Drug Therapy, Combination; Humans;

2022
Combination therapy with albendazole and praziquantel versus albendazole alone in children with seizures and single lesion neurocysticercosis: a randomized, placebo-controlled double blind trial.
    The Pediatric infectious disease journal, 2009, Volume: 28, Issue:5

    Topics: Adolescent; Albendazole; Animals; Anthelmintics; Child; Child, Preschool; Double-Blind Method; Drug

2009
Plasma concentrations of praziquantel during the therapy of neurocysticerosis with praziquantel, in the presence of antiepileptics and dexamethasone.
    The Southeast Asian journal of tropical medicine and public health, 1995, Volume: 26, Issue:1

    Topics: Adult; Anticonvulsants; Antiplatyhelmintic Agents; Biological Availability; Brain Diseases; Cysticer

1995

Other Studies

15 other studies available for praziquantel and Seizures

ArticleYear
Hydatid brain cyst: A delayed diagnosis in a rural setting during COVID-19.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2021, 11-05, Volume: 111, Issue:11

    Topics: Albendazole; Anticestodal Agents; Brain Diseases; Child; COVID-19; Delayed Diagnosis; Echinococcosis

2021
Efficacy and safety of antiparasitic therapy for neurocysticercosis in rural Tanzania: a prospective cohort study.
    Infection, 2023, Volume: 51, Issue:4

    Topics: Albendazole; Anthelmintics; Antiparasitic Agents; Cysts; Humans; Neurocysticercosis; Praziquantel; P

2023
Radiographic Improvement of Larval Cysts in Neurocysticercosis.
    Annals of neurology, 2021, Volume: 89, Issue:2

    Topics: Adult; Albendazole; Anthelmintics; Anticonvulsants; Brain; Humans; Magnetic Resonance Imaging; Male;

2021
Cerebral schistosomiasis--an unusual presentation of an intracranial mass lesion.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2009, Volume: 36, Issue:2

    Topics: Adult; Animals; Anthelmintics; Anti-Inflammatory Agents; Anticonvulsants; Antitubercular Agents; Bra

2009
Seizures related to praziquantel therapy in neurocysticercosis.
    The Medical journal of Australia, 2010, Aug-16, Volume: 193, Issue:4

    Topics: Anthelmintics; Humans; Male; Neurocysticercosis; Praziquantel; Seizures; Young Adult

2010
Neurocysticercosis: an unusual cause of seizure in the New Zealand setting.
    Journal of paediatrics and child health, 2012, Volume: 48, Issue:3

    Topics: Anthelmintics; Child; Humans; Male; Neurocysticercosis; New Zealand; Praziquantel; Radiography; Seiz

2012
Neurocysticercosis in Australia: still free of autochthonous cases?
    The Medical journal of Australia, 2012, Apr-02, Volume: 196, Issue:6

    Topics: Anthelmintics; Female; Frontal Lobe; Humans; Male; Neurocysticercosis; Praziquantel; Refugees; Seizu

2012
Anticysticercal treatment and seizures in neurocysticercosis.
    The Lancet. Neurology, 2004, Volume: 3, Issue:4

    Topics: Albendazole; Animals; Anthelmintics; Clinical Trials as Topic; Humans; Neurocysticercosis; Praziquan

2004
Could neurocysticercosis be the cause of "onchocerciasis-associated" epileptic seizures?
    The American journal of tropical medicine and hygiene, 2008, Volume: 78, Issue:3

    Topics: Albendazole; Animals; Anthelmintics; Epilepsy; Humans; Neurocysticercosis; Onchocerca; Onchocerciasi

2008
Clinical study on cerebral schistosomiasis japonica on Leyte Island, Philippines: follow-up study 6 years after treatment with antischistosomal drugs.
    The Southeast Asian journal of tropical medicine and public health, 1984, Volume: 15, Issue:4

    Topics: Adult; Anticonvulsants; Benzenesulfonates; Brain Diseases; Drug Therapy, Combination; Female; Humans

1984
Neurocysticercosis in Houston, Texas. A report of 112 cases.
    Medicine, 1994, Volume: 73, Issue:1

    Topics: Adolescent; Adult; Animals; Brain Diseases; Child; Cysticercosis; Female; Humans; Male; Middle Aged;

1994
Neurocysticercosis: Report of fifteen cases.
    The Mount Sinai journal of medicine, New York, 1995, Volume: 62, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiplatyhelmintic Agents; Brain Diseases; Child; Cystic

1995
[A case of neurocysticercosis presenting as focal seizure].
    No shinkei geka. Neurological surgery, 2000, Volume: 28, Issue:9

    Topics: Adult; Albendazole; Anthelmintics; Brain Diseases; Combined Modality Therapy; Humans; Male; Neurocys

2000
The course of seizures after treatment for cerebral cysticercosis.
    The New England journal of medicine, 1992, Sep-03, Volume: 327, Issue:10

    Topics: Adult; Albendazole; Brain; Brain Diseases; Cysticercosis; Epilepsy; Female; Follow-Up Studies; Human

1992
Truncal seizures: an unusual presentation of cerebral cysticercosis.
    Annals of emergency medicine, 1986, Volume: 15, Issue:11

    Topics: Adult; Carbamazepine; Cysticercosis; Female; Humans; Movement Disorders; Praziquantel; Prednisone; S

1986