pravastatin has been researched along with Pregnancy in 95 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (5.26) | 18.2507 |
| 2000's | 5 (5.26) | 29.6817 |
| 2010's | 53 (55.79) | 24.3611 |
| 2020's | 32 (33.68) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, MS; Fokina, VM; König, J; Nanovskaya, T; Noguchi, S; Patrikeeva, S; Tomi, M; Wang, XM | 1 |
| Costantine, MM; Smith, DD | 1 |
| Aschenbrenner, DS | 1 |
| Abe, S; Kaneko, K; Kawasaki, H; Murashima, A; Sago, H; Saito, J; Suzuki, T; Yakuwa, N; Yamatani, A | 1 |
| Costantine, MM; Lawrence-Cleary, K; Saade, G; Wapner, RJ | 1 |
| Nguyen, L; Pham, A; Polic, A; Thompson, JL | 1 |
| Arena, V; De Carolis, S; Dell'Aquila, M; Di Stasio, E; Ferrazzani, S; Fruci, S; Gallini, F; Lanzone, A; Moresi, S; Salvi, S | 1 |
| Costantine, MM; Eid, J; Rood, KM | 1 |
| Boekhoudt, TM; Caritis, SN; Clifton, RG; Costantine, MM; Grobman, W; Gyamfi-Bannerman, C; Hebert, MF; Lawrence, K; Longo, M; Saade, GR; Simhan, HN; Wisner, KL | 1 |
| Clifton, RG; Costantine, MM; Saade, GR | 1 |
| Ahmad, S; Ahmed, A; Cheed, V; Daniels, JP; Hewett, P; Khan, KS; Middleton, LJ; Spencer, K; Vince, AT; Wang, K; Williams, DJ | 1 |
| Alasztics, B; Csomó, KB; Czizel, R; Djurecz, M; Hrabák, A; Kecskeméti, A; Kovács, B; Kukor, Z; Pánczél, Z; Supák, D; Valent, S | 1 |
| Birukov, A; Dechend, R; Geisberger, S; Golic, M; Haase, N; Herse, F; Heuser, A; Kräker, K; Müller, DN; O'Driscoll, JM; Patey, O; Schütte, T; Thilaganathan, B; Verlohren, S | 1 |
| Costantine, MM | 3 |
| Gueta, I; Markovits, N; Schacham, YN | 1 |
| Cervar-Zivkovic, M; Mayer-Pickel, K; Moertl, M; Schöll, W; Stern, C | 1 |
| Kovács, B; Kukor, Z; Pánczél, Z; Supák, D; Valent, S | 1 |
| Beard, S; Binder, NK; Brownfoot, FC; de Alwis, N; Hannan, NJ; Kaitu'u-Lino, TJ; Mangwiro, YT; Tong, S | 1 |
| Voto, LS; Zeitune, MG | 1 |
| Fujii, T; Iriyama, T; Kumasawa, K; Nagamatsu, T; Osuga, Y | 1 |
| Alijotas-Reig, J; Bonacina, E; Carreras, E; Ferrer-Oliveras, R; Garcia-Manau, P; Mendoza, M; Rodo, C | 1 |
| Contento, G; Girardi, G; Jurisic, A; Jurisic, Z; Lefkou, E; Pombo, J; Varoudi, K | 1 |
| Brownfoot, F; Cluver, C; Hannan, N; Hastie, R; Kaitu'u-Lino, TJ; Tong, S | 1 |
| Beck, C; Giussani, DA; Itani, N; Katzilieris-Petras, G; Niu, Y; Skeffington, KL; Smith, N | 1 |
| Girardi, G; Jurisic, A; Jurisic, Z; Lefkou, E | 1 |
| Huai, J; Wang, GJ; Xiang, QQ; Yang, Z | 1 |
| Akbar, MIA; Amani, FZ; Dachlan, EG; Dekker, GA; Dikman Angsar, M; Fadhilah, NL; Pratama, RE; Sulistyowati, S; Yosediputra, A | 1 |
| Heinonen, T; Huttala, O; Laivuori, H; Tihtonen, K; Toimela, T; Uotila, J; Virtanen, A | 1 |
| Chen, H; Chen, L; Li, B; Li, W; Lu, K; Ni, Q; Tan, Y; Wang, H | 1 |
| Ahmed, MS; Caritis, S; Clark, S; Costantine, MM; Rytting, E; Stika, CS; Venkataramanan, R; Wang, X; West, H; Wisner, KL | 1 |
| Asher-Landsberg, J; Gamzu, R; Kliger, C; Kupferminc, MJ; Rimon, E; Skornick-Rapaport, A; Yogev, Y | 1 |
| Akolekar, R; Bartha, JL; Cicero, S; Ciobanu, A; De Paco Matallana, C; Del Mar Gil, M; Döbert, M; Greco, E; Janga, D; Jani, JC; Maclagan, K; Mu, AC; Nicolaides, KH; Singh, M; Syngelaki, A; Varouxaki, AN; Wright, D | 1 |
| Bomba-Opoń, D; Kozłowski, S; Lipa, J; Lipa, M | 1 |
| Girardi, G | 3 |
| Gembruch, U; Kühr, M; Merz, WM; Otten, LA; van der Ven, K | 1 |
| Alijotas-Reig, J; Baraldès-Farré, A; Esteve-Valverde, E; Ferrer-Oliveras, R; Gil-Aliberas, N; Llurba, E | 1 |
| Huai, J; Wang, GJ; Yang, Z; Yi, YH | 2 |
| Weber, ML | 1 |
| Bomba-Opon, DA; Gajzlerska-Majewska, W; Wielgos, M | 1 |
| Clark, JE; Garrett, N; Girardi, G; Pombo, J; Simmons, M; Umpierrez, M | 1 |
| Girardi, G; Jurisic, A; Jurisic, Z; Lefkou, E; Pombo, J | 1 |
| Abdel-Rahman, SZ; Afrouzian, M; Ahmed, MS; Al-Lahham, R; Costantine, M; Fischer, WG; Fokina, V; Nanovskaya, T; Patrikeeva, S; Xu, M | 1 |
| Chimini, JS; da Silva, MLS; Dias-Junior, CA; Possomato-Vieira, JS | 1 |
| Burgess, J; Casey, KM; Druzin, ML; Kalish, F; Nayak, NR; Stevenson, DK; Tsur, A; Wong, RJ; Zhao, H | 1 |
| Banek, CT; Bauer, AJ; Capoccia, S; Gilbert, JS; Gillham, H; Needham, K; Regal, JF | 1 |
| Cagampang, FR; Elahi, MM; Hanson, MA; Ohri, SK | 1 |
| Berger, H; DeGorter, MK; Kim, RB; Koren, G; Laskin, CA; Lubetsky, A; Zarek, J | 1 |
| Costantine, MM; Hankins, GD; Kechichian, T; Longo, M; Saad, AF; Saade, GR; Sbrana, E; Tamayo, E; Wen, M; Yin, H | 1 |
| Ahmed, MS; Costantine, MM; Hankins, GD; Nanovskaya, TN; Patrikeeva, SL; Paul, J | 1 |
| Girardi, G; Gonzalez, JM; Jansen, MA; Lennen, RJ; Marshall, I; Pedroni, SM; Serio, A; Wade, J | 1 |
| Carver, AR; Costantine, MM; Hankins, GD; Perez-Polo, JR; Saade, GR; Tamayo, E | 1 |
| Costantine, MM; Gamble, P; Hankins, GD; Kechichian, T; Longo, M; McDonnold, M; Saade, GR; Tamayo, E | 1 |
| Dagklis, T; Fragakis, N; Girardi, G; Lefkou, E; Mamopoulos, A; Nounopoulos, E; Rousso, D; Vosnakis, C | 1 |
| Girardi, G; Gonzalez, JM; Pedroni, SM | 1 |
| Andrikopoulou, M; Burd, I; Carver, AR; Costantine, MM; Gamble, P; Hou, Z; Lei, J; Mori, S; Saade, GR; Tamayo, E; Zhang, J | 1 |
| Brownfoot, FC; Hannan, N; Kaitu'u-Lino, T; Onda, K; Tong, S | 1 |
| Elahi, MM; Matata, BM | 1 |
| Gangooly, S; Jauniaux, E; Muttukrishna, S | 1 |
| Aplin, JD; Forbes, K; Gibson, JM; Shah, VK; Siddals, K; Westwood, M | 1 |
| Cleary, KL; Costantine, M; Roney, K | 1 |
| Chaemsaithong, P; Chaiworapongsa, T; DeCherney, AH; Hassan, SS; Hernandez-Andrade, E; Kim, CJ; Korzeniewski, SJ; McCoy, MC; Romero, R; Segars, JH; Yeo, L | 2 |
| Binder, NK; Brownfoot, FC; Cannon, P; Hannan, NJ; Hastie, R; Kaitu'u-Lino, TJ; Onda, K; Tong, S; Walker, SP | 1 |
| Ahmed, MS; Costantine, M; Hankins, GD; Nanovskaya, TN; Vernikovskaya, DI; Wang, X; Zhang, X | 1 |
| Ahmed, MS; Brown, LM; Caritis, SN; Cleary, K; Costantine, MM; D'Alton, M; Easterling, TR; Haas, DM; Haneline, LS; Hankins, G; Hebert, MF; Ren, Z; Venkataramanan, R; West, H | 1 |
| Clark, SM; Costantine, MM; Diken, ZM; Kechichian, TB; Olson, GL; Saad, AF; Saade, GR | 1 |
| Chapman, KE; Holmes, MC; Miller, MR; Moran, CM; Noble, J; Rog-Zielinska, EA; Seckl, JR; Tesic, D; Thomson, A; Wyrwoll, CS | 1 |
| Brownfoot, FC; Cannon, P; Hannan, NJ; Hastie, R; Kaitu'u-Lino, TJ; Tong, S | 1 |
| Dagklis, T; Girardi, G; Lefkou, E; Mamopoulos, A; Rousso, D; Vosnakis, C | 1 |
| Costantine, MM; Marrs, CC | 1 |
| Balan, A; Beharier, O; Dukler, D; Feinshtein, V; Holcberg, G; Huleihel, M; Swissa, SS; Szaingurten-Solodkin, I | 1 |
| Girardi, G; Redecha, P; Torry, D; van Rooijen, N | 1 |
| Bytautiene, E; Costantine, MM; Hankins, GDV; Longo, M; Lu, F; Saade, GR; Tamayo, E | 1 |
| Ahmed, A; Girardi, G; Khan, Y; Seshan, SV; Singh, J | 1 |
| Hasuwa, H; Ikawa, M; Kidoya, H; Kimura, T; Kumasawa, K; Morioka, Y; Okabe, M; Saito-Fujita, T; Takakura, N | 1 |
| Aubuchon, M; Schulz, LC; Schust, DJ | 1 |
| Ahmed, A; Girardi, G; Singh, J | 1 |
| Bytautiene, E; Costantine, MM; Fox, KA; Hankins, GD; Kechichian, T; Longo, M; Saade, GR; Tamayo, E | 1 |
| Heijmans, BT; Jukema, JW; Kremer, D; Lumey, LH; Putter, H; Sattar, N; Slagboom, PE; Talens, RP; Trompet, S; Westendorp, RG | 1 |
| Giussani, DA; Hansell, JA; Herrera, EA; Kane, AD | 1 |
| Basraon, SK; Costantine, MM; Hankins, GD; Longo, M; Makhlouf, M; Menon, R; Saade, GR | 1 |
| Cleary, K; Costantine, MM | 1 |
| Anthony, FW; Cagampang, FR; Curzen, N; Elahi, MM; Hanson, MA; Ohri, SK | 1 |
| Pickering, TG | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA; Palmoski, MJ; Wang-Iverson, D | 1 |
| Desager, JP; Horsmans, Y | 1 |
| Durham, SK; Flint, OP; Gregg, RE; Masters, BA | 2 |
| Higashi, H; Hirai, A; Kitagawa, M; Nakayama, K; Narumiya, S; Noguchi, Y; Oeda, T; Saito, Y; Tanaka, T; Tatsuno, I; Uchida, D; Yasuda, T | 1 |
| Caroli-Bosc, C; Caroli-Bosc, FX; Delabre, B; Delmont, JP; Demarquay, JF; Le Gall, P; Montet, JC; Pugliese, P; Rampal, P | 1 |
8 review(s) available for pravastatin and Pregnancy
| Article | Year |
|---|---|
Statins in Pregnancy: Can We Justify Early Treatment of Reproductive Aged Women?
Topics: Adult; Atherosclerosis; Cardiovascular Diseases; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Newborn; Lactation; Pravastatin; Pregnancy | 2022 |
Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy.
Topics: Aspirin; Female; Humans; Hypertension; Infant, Newborn; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy, High-Risk | 2023 |
Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia.
Topics: Antibodies, Monoclonal; Antioxidants; Antithrombin III; Biological Products; Blood Component Removal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Micronutrients; Placenta Growth Factor; Plant Extracts; Pravastatin; Pre-Eclampsia; Pregnancy; Proton Pump Inhibitors; Recombinant Proteins; RNA, Small Interfering; Sulfasalazine; Vascular Endothelial Growth Factor Receptor-1 | 2022 |
Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies.
Topics: Animals; Anticholesteremic Agents; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fetal Development; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy | 2017 |
Pravastatin for Preventing and Treating Preeclampsia: A Systematic Review.
Topics: Animals; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Placenta; Placentation; Pravastatin; Pre-Eclampsia; Pregnancy; Randomized Controlled Trials as Topic; Severity of Illness Index | 2018 |
Is pravastatin a milestone in the prevention and treatment of preeclampsia?
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Newborn; Models, Biological; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Safety | 2018 |
Challenges of studying drugs in pregnancy for off-label indications: pravastatin for preeclampsia prevention.
Topics: Abnormalities, Drug-Induced; Biomedical Research; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Off-Label Use; Pravastatin; Pre-Eclampsia; Pregnancy | 2014 |
Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.
Topics: Aged; Cholesterol; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins; Lovastatin; Male; Pravastatin; Pregnancy; Simvastatin | 1996 |
7 trial(s) available for pravastatin and Pregnancy
| Article | Year |
|---|---|
Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial.
Topics: Adult; Double-Blind Method; Female; Gestational Age; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1 | 2020 |
Pravastatin suppresses inflammatory cytokines and endothelial activation in patients at risk of developing preeclampsia: INOVASIA study.
Topics: Biomarkers; Cohort Studies; Cytokines; Female; Humans; Infant, Newborn; Interleukin-6; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor A | 2022 |
A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia.
Topics: Adult; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pilot Projects; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Second; Prenatal Care; Treatment Outcome; Young Adult | 2021 |
Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia.
Topics: Adult; Biomarkers; Comorbidity; Female; Gestational Age; Humans; Incidence; Kaplan-Meier Estimate; Mass Screening; Medication Adherence; Placebos; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prognosis; Risk Assessment; Risk Factors; Treatment Outcome; Young Adult | 2021 |
Quantitative determination of pravastatin and its metabolite 3α-hydroxy pravastatin in plasma and urine of pregnant patients by LC-MS/MS.
Topics: Anticholesteremic Agents; Chromatography, High Pressure Liquid; Female; Humans; Limit of Detection; Liquid-Liquid Extraction; Pravastatin; Pregnancy; Tandem Mass Spectrometry | 2016 |
Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial.
Topics: Adult; Birth Weight; Cholesterol; Double-Blind Method; Female; Fetal Blood; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Newborn; Pilot Projects; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy, High-Risk | 2016 |
Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction.
Topics: Aged; Aged, 80 and over; DNA Methylation; Epigenesis, Genetic; Female; Fetal Nutrition Disorders; Follow-Up Studies; Gene-Environment Interaction; Genetic Loci; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Myocardial Infarction; Pravastatin; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Risk Factors | 2012 |
80 other study(ies) available for pravastatin and Pregnancy
| Article | Year |
|---|---|
Role of Uptake Transporters OAT4, OATP2A1, and OATP1A2 in Human Placental Bio-disposition of Pravastatin.
Topics: Biological Transport; Female; HEK293 Cells; Humans; Organic Anion Transporters; Placenta; Pravastatin; Pregnancy | 2022 |
Reply: Timing of pravastatin initiation for preeclampsia prevention.
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pre-Eclampsia; Pregnancy | 2022 |
Statins No Longer Contraindicated in Pregnancy.
Topics: Atorvastatin; Cardiovascular Diseases; Contraindications; Drug Approval; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pregnancy; United States; United States Food and Drug Administration | 2021 |
Pravastatin concentrations in maternal serum, umbilical cord serum, breast milk and neonatal serum during pregnancy and lactation: A case study.
Topics: Antiphospholipid Syndrome; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant; Infant, Newborn; Lactation; Milk, Human; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Umbilical Cord | 2022 |
Letter by Costantine et al Regarding Article, "Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia".
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pre-Eclampsia; Pregnancy | 2022 |
Pravastatin for severe preeclampsia with growth restriction: Placental findings and infant follow-up.
Topics: Female; Fetal Growth Retardation; Follow-Up Studies; Humans; Infant; Infant, Newborn; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome | 2023 |
Long-term neurodevelopmental follow-up of children exposed to pravastatin in utero.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Male; Mothers; Parturition; Pravastatin; Pre-Eclampsia; Pregnancy | 2023 |
Reply: Investigations of pravastatin for the prevention of preeclampsia.
Topics: Animals; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1 | 2023 |
Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas.
Topics: Adult; Arginine; Benzoquinones; Case-Control Studies; Citrulline; Enzyme Inhibitors; Female; Humans; Lactams, Macrocyclic; Microsomes; Nitric Oxide Synthase Type III; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy | 2019 |
Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia.
Topics: Animals; Cardiac Output; Cardiovascular Diseases; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Postpartum Period; Pravastatin; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2020 |
Pravastatin to ameliorate early-onset pre-eclampsia: promising but not there yet.
Topics: Female; Humans; Pravastatin; Pre-Eclampsia; Pregnancy | 2020 |
Re: Pravastatin to ameliorate early-onset pre-eclampsia: promising but not there yet.
Topics: Female; Humans; Pravastatin; Pre-Eclampsia; Pregnancy | 2020 |
Preeclampsia before fetal viability in women with primary antiphospholipid syndrome- materno-fetal outcomes in a series of 7 cases.
Topics: Adult; Antiphospholipid Syndrome; Female; Fetal Viability; Gestational Age; Heparin, Low-Molecular-Weight; Humans; Hydroxychloroquine; Infant, Premature; Plasma Exchange; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Premature Birth; Respiratory Distress Syndrome, Newborn; Retrospective Studies; Severity of Illness Index; Time Factors | 2020 |
[Effect of pravastatin on tetrahydrobiopterin-sensitive and -resistant NO synthase activity of preeclamptic placentas].
Topics: Biopterins; Female; Humans; Nitric Oxide Synthase; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy | 2020 |
Author's reply re: Pravastatin to ameliorate early onset pre-eclampsia: promising but not there yet.
Topics: Female; Humans; Pravastatin; Pre-Eclampsia; Pregnancy | 2020 |
Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction.
Topics: Cell Survival; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Pravastatin; Pre-Eclampsia; Pregnancy; Rosuvastatin Calcium; Simvastatin; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor Receptor-1 | 2020 |
Re: Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial.
Topics: Dietary Supplements; Double-Blind Method; Female; Humans; Pravastatin; Pre-Eclampsia; Pregnancy | 2020 |
Pravastatin for preeclampsia: From animal to human.
Topics: Animals; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Newborn; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Premature Birth; Proteinuria | 2020 |
Evaluating the Effect of Pravastatin in Early-Onset Fetal Growth Restriction: A Nonrandomized and Historically Controlled Pilot Study.
Topics: Biomarkers; Birth Weight; Female; Fetal Development; Fetal Growth Retardation; Historically Controlled Study; Humans; Infant, Newborn; Pilot Projects; Placenta Growth Factor; Pravastatin; Pregnancy; Pregnancy Outcome; Ultrasonography, Doppler; Ultrasonography, Prenatal; Vascular Endothelial Growth Factor Receptor-1 | 2021 |
Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fetal Growth Retardation; Hemodynamics; Heparin, Low-Molecular-Weight; Humans; Mice; Mice, Inbred C57BL; Nitric Oxide; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome | 2020 |
Protective effects of pravastatin on the embryonic cardiovascular system during hypoxic development.
Topics: Animals; Antioxidants; Chickens; Embryo, Nonmammalian; Female; Heart; Hypoxia; Nitric Oxide; Oxidative Stress; Pravastatin; Pregnancy; Protective Agents | 2020 |
Pravastatin plus L-arginine prevents adverse pregnancy outcomes in women with uteroplacental vascular dysfunction.
Topics: Adult; Arginine; Drug Therapy, Combination; Female; Fetal Growth Retardation; Hemodynamics; Humans; Live Birth; Pilot Projects; Placental Circulation; Placental Insufficiency; Pravastatin; Pre-Eclampsia; Pregnancy; Time Factors; Treatment Outcome; Ultrasonography, Doppler; Ultrasonography, Prenatal | 2021 |
Pravastatin alleviates oxidative stress and decreases placental trophoblastic cell apoptosis through IL-6/STAT3 signaling pathway in preeclampsia rats.
Topics: Animals; Apoptosis; Female; Injections, Intraperitoneal; Interleukin-6; Male; Oxidative Stress; Pravastatin; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Trophoblasts | 2020 |
Angiogenic Effect of Pravastatin Alone and with Sera from Healthy and Complicated Pregnancies Studied by in vitro Vasculogenesis/Angiogenesis Assay.
Topics: Adult; Angiogenesis Inhibitors; Angiogenic Proteins; Case-Control Studies; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Female; Fetal Growth Retardation; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Neovascularization, Physiologic; Pravastatin; Pre-Eclampsia; Pregnancy; Stromal Cells; Young Adult | 2021 |
Pravastatin ameliorated osteoarthritis susceptibility in male offspring rats induced by prenatal ethanol exposure.
Topics: Animals; Cartilage, Articular; Chondrocytes; Ethanol; Female; Male; Osteoarthritis; Pravastatin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2021 |
Pravastatin is useful for prevention of recurrent severe placenta-mediated complications - a pilot study.
Topics: Abruptio Placentae; Aspirin; Female; Fetal Growth Retardation; Heparin, Low-Molecular-Weight; Humans; Pilot Projects; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Retrospective Studies; Stillbirth | 2022 |
An experimental administration of pravastatin in patient with previous, multiple pregnancy losses.
Topics: Abortion, Habitual; Adult; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pregnancy; Pregnancy, High-Risk | 2017 |
Pravastatin for prevention of HELLP syndrome: A case report.
Topics: Adult; Female; Gestational Age; HELLP Syndrome; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Live Birth; Pravastatin; Pregnancy; Recurrence; Term Birth; Treatment Outcome | 2017 |
Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Pravastatin; Pre-Eclampsia; Pregnancy | 2018 |
[Can Pravastatin influence Pregnancies at High-risk for Preeclampsia?]
Topics: Anticholesteremic Agents; Double-Blind Method; Feasibility Studies; Female; Fetal Development; Gestational Age; Humans; Infant, Newborn; Neovascularization, Physiologic; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Second; Pregnancy, High-Risk; Regional Blood Flow; Ultrasonography, Prenatal; Uterus | 2018 |
Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Endothelin-1; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Mice; Mice, Inbred C57BL; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Risk Factors; Vascular Remodeling | 2018 |
Pravastatin and-L-arginine combination improves umbilical artery blood flow and neonatal outcomes in dichorionic twin pregnancies through an nitric oxide-dependent vasorelaxant effect.
Topics: Adult; Animals; Arginine; Blood Flow Velocity; Drug Combinations; Female; Fetal Growth Retardation; Gestational Age; Humans; In Vitro Techniques; Infant, Newborn; Infant, Premature; Live Birth; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Pilot Projects; Pravastatin; Pregnancy; Pregnancy, Twin; Premature Birth; Treatment Outcome; Twins, Dizygotic; Ultrasonography, Prenatal; Umbilical Arteries; Vascular Resistance; Vasodilation; Vasodilator Agents | 2018 |
Role of the efflux transporters BCRP and MRP1 in human placental bio-disposition of pravastatin.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Female; Gene Expression Regulation; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy | 2018 |
Placental nitric oxide formation and endothelium-dependent vasodilation underlie pravastatin effects against angiogenic imbalance, hypertension in pregnancy and intrauterine growth restriction.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Female; Fetal Growth Retardation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pregnancy-Induced; Neovascularization, Physiologic; Nitric Oxide; Oxidative Stress; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Rats; Rats, Wistar; Vasodilation | 2019 |
Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.
Topics: Animals; Drug Evaluation, Preclinical; Female; Heme Oxygenase-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Membrane Proteins; Mice; Placentation; Pravastatin; Pre-Eclampsia; Pregnancy; Random Allocation | 2019 |
Role of mammalian target of rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin.
Topics: Animals; Blotting, Western; Fatty Acids; Female; Immunohistochemistry; Liver; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Pravastatin attenuates hypertension, oxidative stress, and angiogenic imbalance in rat model of placental ischemia-induced hypertension.
Topics: Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Ischemia; Neovascularization, Physiologic; Oxidative Stress; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Trophoblasts; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2013 |
Long-term statin administration to dams on high-fat diet protects not only them but also their offspring from cardiovascular risk.
Topics: Animals; C-Reactive Protein; Cardiovascular Diseases; Diet, High-Fat; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Kidney; Lactation; Lipids; Male; Maternal Nutritional Physiological Phenomena; Mice; Mice, Inbred C57BL; Pravastatin; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Weaning | 2013 |
The transfer of pravastatin in the dually perfused human placenta.
Topics: Female; Half-Life; Humans; Maternal-Fetal Exchange; Perfusion; Placenta; Pravastatin; Pregnancy | 2013 |
Effects of pravastatin on angiogenic and placental hypoxic imbalance in a mouse model of preeclampsia.
Topics: Adenoviridae; Animals; Cell Hypoxia; Disease Models, Animal; Endoglin; Female; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mice; Neovascularization, Physiologic; Placenta; Placenta Growth Factor; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; RNA, Messenger; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Transplacental transfer and distribution of pravastatin.
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Maternal-Fetal Exchange; Placenta; Pravastatin; Pregnancy | 2013 |
Complement inhibition and statins prevent fetal brain cortical abnormalities in a mouse model of preterm birth.
Topics: Animals; Antibodies, Neutralizing; Cells, Cultured; Cerebral Cortex; Complement Activation; Complement C5a; Female; Fetus; Gene Expression Regulation; Glutamic Acid; Humans; Infant, Newborn; Mice; Models, Animal; Neurons; Pravastatin; Pregnancy; Premature Birth; Receptor, Anaphylatoxin C5a; Receptors, Glutamate; Signal Transduction; Simvastatin | 2014 |
The effect of maternal pravastatin therapy on adverse sensorimotor outcomes of the offspring in a murine model of preeclampsia.
Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Disease Models, Animal; Female; Fetal Development; Gait Disorders, Neurologic; Humans; Male; Mice; Postural Balance; Pravastatin; Pre-Eclampsia; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Disorders; Reflex; Sex Factors; Transduction, Genetic; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
The effect of prenatal pravastatin treatment on altered fetal programming of postnatal growth and metabolic function in a preeclampsia-like murine model.
Topics: Analysis of Variance; Animals; Area Under Curve; Blood Glucose; Body Weight; Cell Cycle Proteins; Disease Models, Animal; Female; Fetal Development; Insulin; Male; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Receptors, G-Protein-Coupled; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Clinical improvement and successful pregnancy in a preeclamptic patient with antiphospholipid syndrome treated with pravastatin.
Topics: Adult; Antiphospholipid Syndrome; Blood Pressure; Comorbidity; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Treatment Outcome | 2014 |
Statins prevent cervical remodeling, myometrial contractions and preterm labor through a mechanism that involves hemoxygenase-1 and complement inhibition.
Topics: Adult; Animals; CD55 Antigens; Cervix Uteri; Complement C5a; Connexin 43; Enzyme Inhibitors; Female; Gene Expression Regulation; Heme Oxygenase-1; Humans; Lipopolysaccharides; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Myometrium; Obstetric Labor, Premature; Pravastatin; Pregnancy; Protoporphyrins; Uterine Contraction | 2014 |
Maternal pravastatin prevents altered fetal brain development in a preeclamptic CD-1 mouse model.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Female; Fetal Development; Fetus; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Magnetic Resonance Imaging; Male; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells.
Topics: Adult; Antigens, CD; Case-Control Studies; Drug Evaluation, Preclinical; Endoglin; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Liver X Receptors; Orphan Nuclear Receptors; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Receptors, Cell Surface; Sterols; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Gender differences in the expression of genes involved during cardiac development in offspring from dams on high fat diet.
Topics: Analysis of Variance; Animals; Blood Pressure; Cornified Envelope Proline-Rich Proteins; Cyclin G1; Diet, High-Fat; DNA Primers; Female; Gene Expression Regulation, Developmental; Heart; Heart Ventricles; Male; Maternal Exposure; Mice; Mice, Inbred C57BL; Natriuretic Peptide, Brain; Organ Size; Pravastatin; Pregnancy; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics | 2014 |
In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia.
Topics: Activins; Angiogenic Proteins; Antigens, CD; Antihypertensive Agents; Chorionic Gonadotropin; Chorionic Villi; Dose-Response Relationship, Drug; Endoglin; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydralazine; Labetalol; Methyldopa; Placenta; Placental Hormones; Pravastatin; Pre-Eclampsia; Pregnancy; Receptors, Cell Surface; Time Factors; Tissue Culture Techniques; Vascular Endothelial Growth Factor Receptor-1 | 2014 |
Statins inhibit insulin-like growth factor action in first trimester placenta by altering insulin-like growth factor 1 receptor glycosylation.
Topics: Female; Glycosylation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin-Like Growth Factor I; Placenta; Pravastatin; Pregnancy; Pregnancy Trimester, First; Pyridines; Receptor, IGF Type 1; Signal Transduction | 2015 |
Pravastatin to prevent recurrent fetal death in massive perivillous fibrin deposition of the placenta (MPFD).
Topics: Abortion, Habitual; Adult; Animals; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulins, Intravenous; Placenta Diseases; Pravastatin; Pregnancy; Vascular Endothelial Growth Factor Receptor-1 | 2016 |
Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia.
Topics: Adult; Antigens, CD; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Endoglin; Endothelial Cells; Endothelium, Vascular; Female; Humans; Immunoglobulins; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Receptors, Cell Surface; Signal Transduction; Treatment Outcome; Trophoblasts; Vascular Endothelial Growth Factor Receptor-1; Young Adult | 2015 |
Pravastatin for the prevention of adverse pregnancy outcome: preeclampsia and more?
Topics: Female; Humans; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Vascular Endothelial Growth Factor Receptor-1 | 2017 |
Pravastatin Effects on Placental Prosurvival Molecular Pathways in a Mouse Model of Preeclampsia.
Topics: Animals; Apoptosis; Disease Models, Animal; Female; HSP27 Heat-Shock Proteins; MAP Kinase Signaling System; Mice; Phosphorylation; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; STAT3 Transcription Factor; Vascular Endothelial Growth Factor Receptor-1 | 2016 |
Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Anticholesteremic Agents; Female; Fetal Growth Retardation; Glucocorticoids; Heart Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Placenta Diseases; Pravastatin; Pregnancy; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2016 |
Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta.
Topics: Endoglin; Female; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Rosuvastatin Calcium; Simvastatin; Trophoblasts; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 | 2016 |
Pravastatin to prevent obstetrical complications in women with antiphospholipid syndrome.
Topics: Antiphospholipid Syndrome; Aspirin; Female; Humans; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Complications | 2016 |
Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy.
Topics: Adult; Antiphospholipid Syndrome; Endothelium; Enoxaparin; Female; Fibrinolytic Agents; Gestational Age; Hemodynamics; Heparin, Low-Molecular-Weight; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Risk Factors; Tinzaparin; Uterine Artery | 2016 |
Should We Add Pravastatin to Aspirin for Preeclampsia Prevention in High-risk Women?
Topics: Aspirin; Female; Fibrinolytic Agents; Humans; Pravastatin; Pre-Eclampsia; Pregnancy; Risk Factors | 2017 |
The effects of pravastatin on the normal human placenta: Lessons from ex-vivo models.
Topics: Anticholesteremic Agents; Endoglin; Female; Gene Expression; Humans; In Vitro Techniques; Models, Biological; Nitric Oxide Synthase Type III; Phosphorylation; Placenta; Placenta Growth Factor; Pravastatin; Pregnancy; Vascular Endothelial Growth Factor Receptor-1 | 2017 |
Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury.
Topics: Abortion, Spontaneous; Animals; Animals, Newborn; Anticoagulants; Antithrombin III; Cells, Cultured; Disease Models, Animal; Female; Humans; Infant, Newborn; Male; Mice; Monocytes; Nitrogen Oxides; Oxidative Stress; Placenta; Pravastatin; Pregnancy; Protein Binding; Thrombin; Thromboplastin; Trophoblasts; Vascular Endothelial Growth Factor Receptor-1 | 2009 |
Pravastatin prevents miscarriages in antiphospholipid antibody-treated mice.
Topics: Abortion, Habitual; Animals; Antibodies, Antiphospholipid; Female; Injections, Intraperitoneal; Mice; Mice, Knockout; Mice, Transgenic; Neutrophil Activation; Neutrophils; Pravastatin; Pregnancy; Receptor, PAR-2; Simvastatin; Thromboplastin | 2009 |
Using pravastatin to improve the vascular reactivity in a mouse model of soluble fms-like tyrosine kinase-1-induced preeclampsia.
Topics: Acetylcholine; Animals; Female; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1; Vasomotor System | 2010 |
A new mouse model to explore therapies for preeclampsia.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Leptin; Mice; Mice, Inbred CBA; Mice, Inbred DBA; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Vascular Endothelial Growth Factor A | 2010 |
Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model.
Topics: Animals; Animals, Newborn; Cell Line; Disease Models, Animal; Female; HEK293 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Lentivirus; Male; Mice; Mice, Transgenic; Placenta; Placenta Growth Factor; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Transduction, Genetic; Vascular Endothelial Growth Factor Receptor-1 | 2011 |
Preeclampsia: animal models for a human cure.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lentivirus; Male; Mice; Mice, Transgenic; Placenta; Placenta Growth Factor; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Transduction, Genetic; Vascular Endothelial Growth Factor Receptor-1 | 2011 |
Role of tissue factor in pregnancy complications: crosstalk between coagulation and inflammation.
Topics: Abortion, Habitual; Animals; Anticholesteremic Agents; Blood Coagulation; Complement Activation; Complement System Proteins; Female; Humans; Inflammation; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Thromboplastin | 2011 |
Role of complement component C1q in the onset of preeclampsia in mice.
Topics: Animals; Blood Pressure; Cell Movement; Collagenases; Complement C1q; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Knockout; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Regional Blood Flow; Trophoblasts; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2011 |
Effects of pravastatin on mediators of vascular function in a mouse model of soluble Fms-like tyrosine kinase-1-induced preeclampsia.
Topics: Animals; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1 | 2011 |
Statin treatment depresses the fetal defence to acute hypoxia via increasing nitric oxide bioavailability.
Topics: Animals; Anticholesteremic Agents; Biological Availability; Blood Gas Analysis; Cardiovascular System; Catecholamines; Endocrine System; Female; Fetus; Hypoxia; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Pravastatin; Pregnancy; Sheep; Vasomotor System | 2012 |
Can statins reduce the inflammatory response associated with preterm birth in an animal model?
Topics: Animals; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mice; Pravastatin; Pregnancy; Premature Birth; Simvastatin | 2012 |
Pravastatin for the prevention of preeclampsia in high-risk pregnant women.
Topics: Clinical Trials as Topic; Female; Humans; Pravastatin; Pre-Eclampsia; Pregnancy; Risk Factors | 2013 |
Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring.
Topics: Animals; Anticholesteremic Agents; Blood Pressure; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Female; Hypercholesterolemia; Hypertension; Mice; Mice, Inbred C57BL; Motor Activity; Pravastatin; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors | 2008 |
The Food and Drug Administration and over-the-counter statins: an opportunity lost?
Topics: Adult; Aged; Cardiovascular Diseases; Contraindications; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Nonprescription Drugs; Pravastatin; Pregnancy; Self Administration; United States; United States Food and Drug Administration | 2008 |
In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes.
Topics: Animals; Anticholesteremic Agents; Blood Proteins; Cells, Cultured; Cholesterol; Drug Stability; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Simvastatin | 1995 |
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Butylamines; Cells, Cultured; Cholesterol; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Prodrugs; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Squalene; Sulfonic Acids | 1997 |
HMG CoA reductase inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Autoradiography; Cells, Cultured; Cholesterol; Densitometry; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isotope Labeling; Lovastatin; Mevalonic Acid; Molecular Weight; Muscle Proteins; Muscle, Skeletal; Polyisoprenyl Phosphates; Pravastatin; Pregnancy; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Scintillation Counting; Sesquiterpenes; Tritium | 1997 |
Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression.
Topics: ADP Ribose Transferases; Animals; Astrocytes; Biological Transport; Blood; Botulinum Toxins; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Replication; Enzyme Activation; Female; Gene Expression Regulation, Enzymologic; GTP Phosphohydrolases; Hydroxymethylglutaryl CoA Reductases; Pravastatin; Pregnancy; Protein Prenylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley | 1998 |
Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation: epidemiological study in an unselected population.
Topics: Anticholesteremic Agents; Cholelithiasis; Double-Blind Method; Female; Fenofibrate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Middle Aged; Pravastatin; Pregnancy; Risk Factors; Simvastatin | 2001 |