Compounds > pravastatin
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pravastatin and Genetic Predisposition

pravastatin has been researched along with Genetic Predisposition in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (71.43)29.6817
2010's4 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arnett, DK; Boerwinkle, E; Cheng, S; Davis, BR; Eckfeldt, JH; Ford, CE; Leiendecker-Foster, C; Lynch, AI; Maitland-van der Zee, AH; Peters, BJ1
Buckley, BM; de Craen, AJ; Ford, I; Hegele, RA; Jukema, JW; Packard, C; Peter, I; Polisecki, E; Robertson, M; Schaefer, EJ; Shepherd, J; Simon, JS; Westendorp, RG1
Crosslin, DR; Ginsburg, GS; Messer, C; Reed, CR; Salisbury, BA; Shah, SH; Voora, D; Zhai, J1
King, S; Superko, HR1
Campos, H; Devlin, JJ; Iakoubova, OA; Kirchgessner, TG; Louie, JZ; Sabatine, MS; Sacks, FM; Shiffman, D1
Buckley, BM; Catanese, JJ; de Craen, AJ; Devlin, JJ; Ford, I; Iakoubova, OA; Jukema, JW; Kirchgessner, TG; Louie, JZ; Packard, CJ; Rowland, CM; Sacks, FM; Sattar, N; Shiffman, D; Slagboom, PE; Stott, DJ; Trompet, S; Westendorp, RG1
Agema, WR; Boekholdt, SM; Jukema, JW; Kastelein, JJ; Peters, RJ; Reitsma, PH; van der Wall, EE; Zwinderman, AH1
Agema, WR; Boer, JM; de Maat, MP; Feskens, EJ; Jukema, JW; Kastelein, JJ; Rabelink, TJ; van Boven, AJ; van der Wall, EE; Zwinderman, AH1
Hofman, MK; Jukema, JW; Princen, HM; Zwinderman, AH1
Braunwald, E; DelMonte, T; Devlin, JJ; Dracopoli, NC; Hui, L; Iakoubova, OA; Kirchgessner, TG; Ranade, K; Sabatine, MS; Sacks, FM; Shaw, PM; Tsuchihashi, Z; Vishnupad, P; White, TJ1
De Boer, A; De Knijff, P; Hallman, DM; Jukema, JW; Kastelein, JJ; Maitland-van der Zee, AH; Zwinderman, AH1
Campos, H; Catanese, JJ; Chokkalingam, AP; Devlin, JJ; Iakoubova, OA; Kirchgessner, TG; Leong, DU; Lew, D; Louie, JZ; Luke, MM; Packard, CJ; Ploughman, LM; Rowland, CM; Sabatine, MS; Sacks, FM; Shaw, PM; Shepherd, J; Tong, CH; Tsuchihashi, Z; Young, BA; Zerba, KE1
Buckley, BM; de Craen, AJ; Ford, I; Jukema, JW; Maeda, N; McMahon, AD; Muallem, H; Ordovas, JM; Packard, C; Peter, I; Polisecki, E; Robertson, M; Schaefer, EJ; Shepherd, J; Westendorp, RG1
Blauw, GJ; Buckley, BM; de Craen, AJ; Ford, I; Jukema, JW; McMahon, AD; Murphy, MB; Ordovas, JM; Packard, C; Peter, I; Polisecki, E; Robertson, M; Schaefer, EJ; Shepherd, J; Trompet, S; Westendorp, RG1

Trials

11 trial(s) available for pravastatin and Genetic Predisposition

ArticleYear
The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.
    Pharmacogenetics and genomics, 2009, Volume: 19, Issue:5

    Topics: Aged; Blood Coagulation Factors; Coronary Disease; Drug Resistance; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Hypolipidemic Agents; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; Pravastatin; Treatment Outcome

2009
Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.
    Journal of lipid research, 2010, Volume: 51, Issue:5

    Topics: Aged; Aged, 80 and over; Coronary Disease; Female; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Humans; Lipoproteins; Male; Membrane Proteins; Membrane Transport Proteins; Polymorphism, Single Nucleotide; Pravastatin; Risk; Treatment Outcome

2010
Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.
    Circulation. Cardiovascular genetics, 2008, Volume: 1, Issue:2

    Topics: Adolescent; Adult; Aged; Alleles; Anticholesteremic Agents; Apolipoprotein E3; Atorvastatin; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cholesterol, LDL; Dose-Response Relationship, Drug; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Middle Aged; Polymorphism, Single Nucleotide; Pravastatin; Pyrroles; Regression Analysis; Simvastatin

2008
Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial.
    The American journal of cardiology, 2010, May-01, Volume: 105, Issue:9

    Topics: Alleles; Atherosclerosis; Cholesterol; DNA; Dose-Response Relationship, Drug; Double-Blind Method; Female; Genetic Predisposition to Disease; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinesins; Male; Middle Aged; Myocardial Infarction; Polymerase Chain Reaction; Polymorphism, Genetic; Pravastatin; Prevalence; Prospective Studies; Risk Factors; Secondary Prevention; Survival Rate; Treatment Outcome; United States

2010
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Aged; Coronary Disease; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Pravastatin

2012
Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events.
    Circulation, 2003, May-20, Volume: 107, Issue:19

    Topics: Amino Acid Substitution; Cohort Studies; Coronary Artery Disease; Disease Progression; Disease-Free Survival; Drosophila Proteins; Gene Frequency; Genetic Carrier Screening; Genetic Predisposition to Disease; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Membrane Glycoproteins; Multicenter Studies as Topic; Polymorphism, Genetic; Pravastatin; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Cell Surface; Risk Assessment; Toll-Like Receptor 4; Toll-Like Receptors; Treatment Outcome

2003
An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men.
    Clinical science (London, England : 1979), 2004, Volume: 107, Issue:3

    Topics: Anticholesteremic Agents; Case-Control Studies; Coronary Angiography; Coronary Disease; Disease Progression; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Pravastatin; Statistics, Nonparametric

2004
Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events.
    Clinical science (London, England : 1979), 2005, Volume: 108, Issue:6

    Topics: Analysis of Variance; Chi-Square Distribution; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Coronary Artery Disease; Double-Blind Method; Gene Frequency; Genetic Predisposition to Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Middle Aged; Polymorphism, Genetic; Pravastatin; Promoter Regions, Genetic; Risk Assessment; Triglycerides

2005
Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS).
    Acta cardiologica, 2006, Volume: 61, Issue:3

    Topics: Aged; Anticholesteremic Agents; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Genetic Carrier Screening; Genetic Predisposition to Disease; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Polymorphism, Genetic; Pravastatin; Regression Analysis; Statistics as Topic; Treatment Outcome; Triglycerides

2006
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.
    Atherosclerosis, 2008, Volume: 200, Issue:1

    Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Female; Genetic Predisposition to Disease; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Polymorphism, Single Nucleotide; Pravastatin; Receptors, LDL; Risk Factors; Triglycerides

2008
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.
    Atherosclerosis, 2008, Volume: 200, Issue:1

    Topics: Aged; Aged, 80 and over; Cholesterol, LDL; Coronary Disease; Female; Genetic Predisposition to Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Linkage Disequilibrium; Male; Odds Ratio; Polymorphism, Single Nucleotide; Pravastatin; Proprotein Convertase 9; Proprotein Convertases; Serine Endopeptidases

2008

Other Studies

3 other study(ies) available for pravastatin and Genetic Predisposition

ArticleYear
Letter by Superko and King regarding article, "Lipid Treatment Assessment Project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals".
    Circulation, 2010, Mar-09, Volume: 121, Issue:9

    Topics: Atorvastatin; C-Reactive Protein; Cholesterol, LDL; Female; Genetic Predisposition to Disease; Goals; Guideline Adherence; Health Care Surveys; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kinesins; Male; Middle Aged; Mutation, Missense; Patient Selection; Pravastatin; Pyrroles; Risk

2010
Evaluation of the paraoxonases as candidate genes for stroke: Gln192Arg polymorphism in the paraoxonase 1 gene is associated with increased risk of stroke.
    Stroke, 2005, Volume: 36, Issue:11

    Topics: Arginine; Aryldialkylphosphatase; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Glutamine; Heterozygote; Homozygote; Humans; Lipoproteins, LDL; Male; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Pravastatin; Risk; Risk Factors; Stroke

2005
Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:12

    Topics: Alleles; Anticholesteremic Agents; Antigens, CD; Asparagine; Aspartic Acid; Coronary Disease; Genetic Predisposition to Disease; Genotype; Humans; Male; Myocardial Infarction; Odds Ratio; Polymorphism, Single Nucleotide; Pravastatin; Receptors, Fc; Risk Factors; Scotland

2006