pravastatin and Disease Models, Animal

Topics: Animals; Anticholesteremic Agents; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fetal Development; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy

Topics: Animals; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Placenta; Placentation; Pravastatin; Pre-Eclampsia; Pregnancy; Randomized Controlled Trials as Topic; Severity of Illness Index

Topics: Adjuvants, Immunologic; Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Anticholesteremic Agents; Antineoplastic Agents, Hormonal; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cyclohexanes; Disease Models, Animal; Genetic Therapy; Humans; Immunotherapy; Liver Neoplasms; Meta-Analysis as Topic; Mice; Multicenter Studies as Topic; O-(Chloroacetylcarbamoyl)fumagillol; Octreotide; Pilot Projects; Pravastatin; Primary Prevention; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Sesquiterpenes; Tamoxifen; Thymus Extracts; Time Factors

Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection

Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger

Topics: Animals; Atorvastatin; Combinatorial Chemistry Techniques; Disease Models, Animal; Fluorobenzenes; Hepatocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Molecular Structure; Muscle Cells; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides

Topics: Animals; Antimalarials; Artemisinins; Artesunate; Atorvastatin; Disease Models, Animal; Drug Synergism; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Malaria, Cerebral; Malaria, Falciparum; Mice; Neuroprotective Agents; Pravastatin; Pyrroles; Simvastatin

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Acute Lung Injury; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Capillary Permeability; Caveolin 1; Disease Models, Animal; Endothelial Cells; Humans; Male; Mice; Nitric Oxide Synthase Type III; Pravastatin; Pulmonary Alveoli; Sepsis

Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Immunity, Innate; Interleukin-1 Receptor-Like 1 Protein; Interleukin-13; Interleukin-33; Intestinal Diseases; Lymphocytes; Male; Mice; Mice, Knockout; Pravastatin; Reperfusion Injury

Topics: Animals; Biopsy; Caco-2 Cells; Computational Biology; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Humans; Intestinal Diseases; Intestinal Mucosa; Male; Metallothionein; Mice; Pravastatin; Radiation Injuries; Radiation, Ionizing; Swine; Swine, Miniature; Tight Junctions

Topics: Animals; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Contrast Media; Diet, High-Fat; Disease Models, Animal; Elastin; Feasibility Studies; Ferrosoferric Oxide; Gadolinium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout, ApoE; Nitric Oxide; Plaque, Atherosclerotic; Pravastatin; Sensitivity and Specificity

Topics: Animals; Cardiac Output; Cardiovascular Diseases; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Postpartum Period; Pravastatin; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Ventricular Remodeling

Topics: Animals; Disease Models, Animal; Gene Dosage; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Pravastatin

Topics: Animals; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Disease Models, Animal; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Plant Extracts; Plaque, Atherosclerotic; Pravastatin; Prosopis; Rabbits; Triglycerides

Topics: Animals; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes; Mice; Pravastatin; Proctitis; THP-1 Cells; Thrombomodulin

Topics: 5' Untranslated Regions; Animals; Betaxolol; Cell Line; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Internal Ribosome Entry Sites; Mice; Mice, Inbred mdx; Mice, Knockout; Muscular Dystrophy, Duchenne; Myoblasts; Peptide Elongation Factor 1; Pravastatin; Protein Biosynthesis; Up-Regulation; Utrophin

Topics: Aging; Animals; Bone and Bones; Bone Density Conservation Agents; Cartilage; Disease Models, Animal; Femur; Glycosaminoglycans; Joints; Lamin Type A; Mice; Mice, Transgenic; Mutation; Osteoarthritis; Phenotype; Piperidines; Pravastatin; Progeria; Protein Processing, Post-Translational; Pyridines; X-Ray Microtomography; Zoledronic Acid

Topics: Animals; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Plaque, Atherosclerotic; Pravastatin

Topics: Animals; Anti-Inflammatory Agents; Aortitis; Atherosclerosis; Brachiocephalic Trunk; Collagen; Disease Models, Animal; Disease Progression; Inflammation Mediators; Interleukin-6; Lipid Metabolism; Male; Mice, Knockout, ApoE; Minocycline; Necrosis; Plaque, Atherosclerotic; Pravastatin; Time Factors

Topics: Age Factors; Animals; Aorta; Aortic Diseases; Atherosclerosis; Calcium; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipids; Mice, Inbred C57BL; Mice, Knockout, ApoE; Plaque, Atherosclerotic; Pravastatin; Rupture, Spontaneous; Time Factors; Vascular Calcification

Topics: Animals; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Myocardium; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA

Topics: Animals; Arterial Pressure; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Pravastatin; Pre-Eclampsia; Pregnancy

Topics: Animals; Blood Glucose; Body Weight; Diet, Carbohydrate Loading; Diet, High-Fat; Disease Models, Animal; Heart; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Insulin Resistance; Lipid Peroxidation; Male; Mitochondria; Mitochondrial Dynamics; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Obesity; Pravastatin; Rats; Rats, Wistar; Risk Factors

Topics: Adiponectin; Adipose Tissue; Animals; Anti-Asthmatic Agents; Antibodies; Asthma; Bronchoconstriction; Diet, High-Fat; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-17; Leptin; Lung; Mice, Inbred C57BL; Obesity; Pravastatin; Th17 Cells; Th2 Cells

Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Endothelin-1; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Mice; Mice, Inbred C57BL; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Risk Factors; Vascular Remodeling

Topics: Animals; Anticholesteremic Agents; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Cholesterol; Disease Models, Animal; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Plaque, Atherosclerotic; Pravastatin

Topics: Adaptor Proteins, Signal Transducing; Animals; Anticholesteremic Agents; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Hyperlipidemias; Interleukin-1; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Pravastatin; Triggering Receptor Expressed on Myeloid Cells-1; Tumor Necrosis Factor-alpha

Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Female; Fetal Growth Retardation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pregnancy-Induced; Neovascularization, Physiologic; Nitric Oxide; Oxidative Stress; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Rats; Rats, Wistar; Vasodilation

Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Cell Adhesion Molecules; Cholesterol, Dietary; Cilostazol; Cytokines; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Lipids; Male; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Pravastatin; Receptors, LDL

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cilostazol; Clopidogrel; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipopolysaccharides; Male; Mice; Platelet Aggregation Inhibitors; Pravastatin; Rosuvastatin Calcium; Treatment Outcome; Tumor Necrosis Factor-alpha

Topics: Animals; Blood Pressure; Cells, Cultured; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Ischemia; Neovascularization, Physiologic; Oxidative Stress; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Trophoblasts; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

Topics: Adenoviridae; Animals; Cell Hypoxia; Disease Models, Animal; Endoglin; Female; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mice; Neovascularization, Physiologic; Placenta; Placenta Growth Factor; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; RNA, Messenger; Signal Transduction; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Pravastatin; Tachycardia, Ventricular

Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Disease Models, Animal; Female; Fetal Development; Gait Disorders, Neurologic; Humans; Male; Mice; Postural Balance; Pravastatin; Pre-Eclampsia; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Disorders; Reflex; Sex Factors; Transduction, Genetic; Vascular Endothelial Growth Factor Receptor-1

Topics: Analysis of Variance; Animals; Area Under Curve; Blood Glucose; Body Weight; Cell Cycle Proteins; Disease Models, Animal; Female; Fetal Development; Insulin; Male; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Receptors, G-Protein-Coupled; Vascular Endothelial Growth Factor Receptor-1

Topics: Adipogenesis; Adipose Tissue; Adrenal Cortex Hormones; Animals; beta Catenin; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Femur Head; Femur Head Necrosis; Fibrinolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipids; Low Density Lipoprotein Receptor-Related Protein-5; Male; Methylprednisolone; Neovascularization, Physiologic; Osteogenesis; Osteonecrosis; PPAR gamma; Pravastatin; Rats; Rats, Wistar; Wnt Signaling Pathway; Wnt3A Protein

Topics: Animals; Apolipoproteins E; Carotid Artery Diseases; Carotid Stenosis; Disease Models, Animal; Drug Monitoring; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imaging, Three-Dimensional; Mice; Mice, Inbred C57BL; Mice, Knockout; Pravastatin; Random Allocation; Tomography, Optical Coherence

Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Aorta; Ceruloplasmin; Cholesterol; Coronary Artery Disease; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Nebivolol; NG-Nitroarginine Methyl Ester; Pravastatin; Rats; Rats, Wistar; Triglycerides; Uric Acid

Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Female; Fetal Development; Fetus; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Magnetic Resonance Imaging; Male; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1

Topics: Alkylating Agents; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma in Situ; Carcinoma, Ductal, Breast; Carcinoma, Papillary; Disease Models, Animal; Drug Synergism; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Pravastatin; Rats, Sprague-Dawley

Topics: Animals; Apoptosis; Blood Pressure; Body Weight; Bone Marrow Cells; Bone Marrow Transplantation; Cell Movement; Chemokine CXCL5; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glomerular Filtration Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Male; Pravastatin; Rats; Rats, Inbred Lew; Renal Insufficiency, Chronic; Tissue Donors; Transplantation, Homologous

Topics: Administration, Intravenous; Administration, Oral; Animals; Body Fluids; Carbamates; Cell Separation; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Feces; Hepatocytes; Intestinal Absorption; Liver; Male; Paroxetine; Piperidines; Pravastatin; Rats, Sprague-Dawley; Tissue Distribution

Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cardiomegaly; Cell Proliferation; Cells, Cultured; Chemokines; Cytoskeletal Proteins; Disease Models, Animal; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Myocytes, Cardiac; Pravastatin; Random Allocation; Rats; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Role; Species Specificity

Topics: Animals; Apoptosis; Disease Models, Animal; Female; HSP27 Heat-Shock Proteins; MAP Kinase Signaling System; Mice; Phosphorylation; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; STAT3 Transcription Factor; Vascular Endothelial Growth Factor Receptor-1

Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Anticholesteremic Agents; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, Western; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Male; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Phosphorylation; Pravastatin; Signal Transduction; Transcription Factor AP-2

Topics: Animals; Bone Density Conservation Agents; Cell Nucleus; Diphosphonates; Disease Models, Animal; Drug Therapy, Combination; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Lamin Type A; Longevity; Mice; Mice, Knockout; Nuclear Proteins; Pravastatin; Prenylation; Progeria; Protein Precursors; Tumor Suppressor Protein p53; Zoledronic Acid

Topics: Animals; Cholesterol; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Inflammation; Interleukin-6; Kidney; Mice; Pravastatin; Reperfusion Injury

Topics: Actins; Animals; Bone Marrow Cells; CD18 Antigens; Cell Differentiation; Cells, Cultured; Chemokine CXCL12; Disease Models, Animal; Down-Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Hypoxia; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Proto-Oncogene Proteins c-kit; Receptors, CXCR4; Stem Cells; Vascular Endothelial Growth Factor Receptor-2

Topics: AC133 Antigen; Animals; Antigens, CD; Bone Marrow Cells; Cell Movement; Cell Proliferation; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Dose-Response Relationship, Drug; GATA4 Transcription Factor; Glycoproteins; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mitosis; Muscle Development; Myocardial Contraction; Myocytes, Cardiac; Peptides; Pravastatin; Proto-Oncogene Proteins c-kit; Regeneration; Stem Cells; Swine

Topics: Animals; Connexin 43; Coxsackievirus Infections; Disease Models, Animal; Interferon-gamma; Interleukin-10; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Pravastatin

Topics: Animals; Atorvastatin; Disease Models, Animal; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Male; Monocrotaline; Phosphodiesterase Inhibitors; Pravastatin; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Simvastatin

Topics: Animals; Blood Vessels; Cell Communication; Chemokine CCL2; Chemokine CXCL1; Disease Models, Animal; E-Selectin; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Pravastatin; Radiodermatitis; Radiotherapy; Skin

Topics: Abortion, Spontaneous; Animals; Animals, Newborn; Anticoagulants; Antithrombin III; Cells, Cultured; Disease Models, Animal; Female; Humans; Infant, Newborn; Male; Mice; Monocytes; Nitrogen Oxides; Oxidative Stress; Placenta; Pravastatin; Pregnancy; Protein Binding; Thrombin; Thromboplastin; Trophoblasts; Vascular Endothelial Growth Factor Receptor-1

Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anticholesteremic Agents; Apolipoprotein A-I; Astrocytes; Chemokine CCL2; Cholesterol; Cognition; Disease Models, Animal; Drug Therapy, Combination; Hippocampus; Interleukin-1beta; Male; Maze Learning; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Pravastatin; Protease Nexins; Receptors, Cell Surface; Tumor Necrosis Factor-alpha

Topics: Animals; Coronary Vessels; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Male; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Superoxides

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Animals; Cell Survival; Disease Models, Animal; Dopamine; Humans; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neuroglia; Neurons; Neuroprotective Agents; Neurotransmitter Agents; NF-kappa B; Parkinson Disease; Parkinsonian Disorders; Pravastatin; Proto-Oncogene Proteins p21(ras); Simvastatin; Substantia Nigra

Topics: Animals; Apoptosis; Body Weight; Carbon Tetrachloride; Cell Line, Transformed; Disease Models, Animal; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Mitochondria; Organ Size; Pravastatin; Protein Kinase C; Protein Kinase Inhibitors; Thioacetamide

Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Choroid; Choroid Diseases; Disease Models, Animal; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Male; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Triglycerides

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cerebral Arteries; Circle of Willis; Corrosion Casting; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelial Cells; Hydralazine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Intracranial Aneurysm; Microscopy, Electron, Scanning; Pravastatin; Rats; Tetrazoles; Treatment Outcome; Vasodilator Agents

Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Heart; Humans; In Vitro Techniques; Male; Myocardial Infarction; Myocytes, Cardiac; Potassium Channels; Pravastatin; Protective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species

Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blotting, Western; Bosentan; Cardiac Pacing, Artificial; Connexin 43; Disease Models, Animal; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Maleimides; Mevalonic Acid; Myocardial Infarction; Myocardium; Pravastatin; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Time Factors; Ultrasonography

Topics: Animals; Apolipoprotein A-I; Apolipoproteins E; Bone Density; Chemokines; Cytokines; Disease Models, Animal; fas Receptor; Female; Immunoglobulin G; Lipids; Lupus Erythematosus, Systemic; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptides; Plaque, Atherosclerotic; Pravastatin

Topics: Animals; Antigens, Differentiation; Atherosclerosis; Cell Line; Disease Models, Animal; DNA-Binding Proteins; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Eukaryotic Initiation Factor-2; Fatty Acids; Heat-Shock Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice; Mice, Knockout; Phosphorylation; Pravastatin; Receptors, LDL; Regulatory Factor X Transcription Factors; Simvastatin; Stress, Physiological; Transcription Factors

Topics: Animals; Anticholesteremic Agents; Aorta; Coronary Vessels; Disease Models, Animal; Guanosine Triphosphate; Injections, Intravenous; Male; NADPH Oxidases; Nitric Oxide Synthase Type III; Pravastatin; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; rhoA GTP-Binding Protein; Signal Transduction; Thrombin; Vasodilation

Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Connective Tissue Growth Factor; Cyclin D1; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression; Hydroxyproline; Mice; Mice, Inbred C57BL; Pravastatin; Pulmonary Fibrosis; Respiratory Distress Syndrome; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Transforming Growth Factor beta1

Topics: Animals; Collateral Circulation; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Portal; Indomethacin; Male; Nitric Oxide Synthase; Nitroarginine; Portal System; Pravastatin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Time Factors; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents

Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Leptin; Mice; Mice, Inbred CBA; Mice, Inbred DBA; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Vascular Endothelial Growth Factor A

Topics: Analysis of Variance; Animals; Antiprotozoal Agents; Body Weight; Cricetinae; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leishmania mexicana; Leishmaniasis, Cutaneous; Male; Mesocricetus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pravastatin; Statistics, Nonparametric; Survival Rate

Topics: Animals; Animals, Newborn; Cell Line; Disease Models, Animal; Female; HEK293 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Lentivirus; Male; Mice; Mice, Transgenic; Placenta; Placenta Growth Factor; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Transduction, Genetic; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lentivirus; Male; Mice; Mice, Transgenic; Placenta; Placenta Growth Factor; Pravastatin; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Transduction, Genetic; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Bile Acids and Salts; Cholestasis; Cholesterol; Chronic Disease; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Homeostasis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Male; Membrane Transport Proteins; Permeability; Pravastatin; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transcription Factors

Topics: Animals; Apoptosis; Brain; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Estrogens; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Intracranial Aneurysm; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin

Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Pravastatin; Rats; Rats, Wistar; Simvastatin; Streptozocin

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Disease Models, Animal; Hepatic Encephalopathy; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Failure, Acute; Male; Nitric Oxide; Nitric Oxide Synthase; Pravastatin; Rats; Rats, Sprague-Dawley; Thioacetamide

Topics: Animals; Blood Pressure; Cell Movement; Collagenases; Complement C1q; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Knockout; Placenta; Pravastatin; Pre-Eclampsia; Pregnancy; Regional Blood Flow; Trophoblasts; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Aortic Diseases; Dilatation, Pathologic; Disease Models, Animal; Elastin; Endoplasmic Reticulum; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Losartan; Male; Marfan Syndrome; Mice; Mice, Mutant Strains; Muscle, Smooth, Vascular; Pravastatin; Treatment Outcome; Tunica Media

Topics: Animals; Antimicrobial Cationic Peptides; Cation Transport Proteins; Cholestasis; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase-1; Hepcidins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iron; Liver; Male; Pravastatin; Rats; Rats, Wistar

Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Colony Count, Microbial; Disease Models, Animal; Farnesol; Female; Mice; Mice, Inbred C3H; Pravastatin; Survival Analysis; Virulence Factors

Topics: Animals; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Pravastatin; Pre-Eclampsia; Pregnancy; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Cicatrix, Hypertrophic; Disease Models, Animal; Ear; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Rabbits; Simvastatin; Wound Healing

Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Bone Marrow; Disease Models, Animal; Drinking Water; Femur Head Necrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Lipid Metabolism; Male; Methylprednisolone; Methylprednisolone Acetate; Oxidative Stress; Pravastatin; Rats; Rats, Inbred SHR

Topics: Animals; Anticholesteremic Agents; Disease Models, Animal; Hypercholesterolemia; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pravastatin; Proto-Oncogene Proteins c-akt; Rabbits; Simvastatin

Topics: Animals; Aorta, Thoracic; Aortic Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pravastatin; Protein Kinases; Protein Phosphatase 2; Rats; Rats, Inbred OLETF; Signal Transduction; src-Family Kinases; Time Factors; Vasoconstriction; Vasoconstrictor Agents

Topics: Animals; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mice; Pravastatin; Pregnancy; Premature Birth; Simvastatin

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticholesteremic Agents; Aorta; Aorta, Abdominal; Atherosclerosis; Cholesterol; Cholesterol, LDL; Diet, High-Fat; Disease Models, Animal; Histamine; Hyperlipidemias; Male; Plaque, Atherosclerotic; Pravastatin; Rabbits; Thrombosis; Thromboxane B2; Triglycerides; Viper Venoms

Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred ICR; Neutropenia; NF-kappa B; Pravastatin; Pulmonary Edema; Respiratory Distress Syndrome; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

Topics: Animals; Cell Adhesion Molecules; Cell Membrane Permeability; Cholesterol; Colitis; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Hydroxymethylglutaryl CoA Reductases; Immunoglobulins; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucoproteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pravastatin; RNA, Messenger

Topics: Administration, Oral; Animals; Atorvastatin; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Glucose; Glucose Tolerance Test; Heptanoic Acids; Injections, Intravenous; Insulin; Insulin Secretion; Male; Pravastatin; Pyrroles; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors

Topics: Animals; Aorta, Abdominal; Arteriosclerosis; Cold Temperature; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Isoantigens; Male; Pravastatin; Rats; Rats, Inbred BN; Rats, Inbred Lew; Transplantation, Homologous; Transplantation, Isogeneic; Tunica Intima

Topics: Animals; Bile Ducts; Cholestasis; Disease Models, Animal; Hyperbilirubinemia; Male; Pravastatin; Rats; Rats, Sprague-Dawley; Thiazepines

Topics: Animals; Blood Glucose; Chemokine CCL2; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA Primers; Glucose Tolerance Test; Hydroxymethylglutaryl CoA Reductases; Immunohistochemistry; Insulin; Leptin; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pravastatin; Rats; Rats, Inbred OLETF; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha; Ventricular Remodeling

Topics: Adenosine Triphosphate; Animals; Anticholesteremic Agents; Disease Models, Animal; Heart; Hypercholesterolemia; Hypertrophy, Left Ventricular; Male; Potassium Channels; Pravastatin; Rabbits

Topics: Animals; Anions; Area Under Curve; ATP-Binding Cassette Transporters; Blood Proteins; Creatine Kinase; Disease Models, Animal; Folic Acid Antagonists; Half-Life; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperbilirubinemia; Male; Methotrexate; Muscle, Skeletal; Pravastatin; Protein Binding; Rats; Rats, Inbred Strains; Toxicity Tests; Weight Gain

Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glomerular Filtration Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pravastatin; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Circulation; Renal Insufficiency; Triglycerides; Urine

Topics: Animals; C-Reactive Protein; Cyclosporine; Disease Models, Animal; Fibrosis; Inflammation; Kidney; Kidney Diseases; Losartan; Male; Pravastatin; Rats; Rats, Sprague-Dawley

Topics: Animals; Blood Platelets; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Inhibitory Concentration 50; Leukocytes, Mononuclear; Macrophages, Peritoneal; Male; Mice; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitro Compounds; P-Selectin; Platelet Adhesiveness; Platelet Aggregation; Pravastatin; Pulmonary Embolism; RNA, Messenger; Spleen; Thromboplastin

Topics: Animals; Biopsy, Needle; Cell Proliferation; Disease Models, Animal; Graft Rejection; Graft Survival; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Jugular Veins; Male; Pravastatin; Preoperative Care; Probability; Protein Serine-Threonine Kinases; Rabbits; Random Allocation; Reference Values; rho-Associated Kinases; Risk Factors; Sensitivity and Specificity; Tunica Intima; Vascular Surgical Procedures

Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Eicosapentaenoic Acid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperbilirubinemia; Muscle, Skeletal; Platelet Aggregation Inhibitors; Pravastatin; Rats; Rhabdomyolysis; Severity of Illness Index; Treatment Outcome

Topics: Animals; Atherosclerosis; Blood Platelets; Disease Models, Animal; Male; Nitric Oxide; Nitric Oxide Synthase; Pravastatin; Rabbits; RNA, Messenger

Topics: Acetic Acid; Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Male; Malondialdehyde; Nitric Oxide; Pravastatin; Rats; Rats, Sprague-Dawley; Superoxide Dismutase

Topics: Animals; Basement Membrane; Biomarkers; Blood-Brain Barrier; Cerebral Arterial Diseases; Cerebral Arteries; Cerebral Infarction; Collagen Type IV; Disease Models, Animal; Down-Regulation; Hemoglobins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperemia; Ischemic Attack, Transient; Male; Microcirculation; Pravastatin; Rats; Rats, Wistar; Reperfusion Injury

Topics: Animals; Axons; Cytoprotection; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Male; Neuroprotective Agents; Oxidative Stress; Peripheral Nerves; Pravastatin; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sciatic Neuropathy; Time Factors; Treatment Outcome; Wallerian Degeneration

Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Biological Availability; C-Reactive Protein; Disease Models, Animal; Down-Regulation; Drug Interactions; Electrocardiography; Heart Conduction System; Heart Rate; Inflammation; Interferon-gamma; Interleukin-10; Male; Mycobacterium; Nitrites; Pravastatin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Time Factors

Topics: Animals; Arthritis, Experimental; Aspartate Aminotransferases; Blood Urea Nitrogen; Chemokine CCL2; Chemokines; Collagen Type II; Corticosterone; Creatine Kinase; Creatinine; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred DBA; Pravastatin; RNA, Messenger; Synovial Membrane

Topics: Animals; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Imidazoles; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Pravastatin; Rats; Rats, Inbred Dahl; Reference Values; Risk Factors; Sensitivity and Specificity; Sodium Chloride, Dietary; Tetrazoles; Vascular Diseases

Topics: Adiponectin; Adipose Tissue; Animals; Anticholesteremic Agents; Atorvastatin; Chemokine CCL2; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; Glucose; Heptanoic Acids; Hypertriglyceridemia; Insulin Resistance; Leptin; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Pravastatin; Pyrroles; Rats; Rats, Long-Evans; Rats, Mutant Strains; RNA, Messenger; Transforming Growth Factor beta1; Ventricular Dysfunction, Left

Topics: Animals; Aorta, Thoracic; Atherosclerosis; Calcium Channel Blockers; Cholesterol; Dihydropyridines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperplasia; Male; Pravastatin; Rabbits; RNA, Messenger; Scavenger Receptors, Class E; Time Factors; Tunica Intima; Up-Regulation; Vascular Cell Adhesion Molecule-1; Vasodilation

Topics: Adipocytes; Adiponectin; Animals; Diabetes Mellitus; Disease Models, Animal; Glucose; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Obesity; Pravastatin

Topics: Animals; Biomarkers; Disease Models, Animal; Female; Follow-Up Studies; Gastric Mucosa; Gastritis; Gene Expression; Helicobacter Infections; Helicobacter pylori; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Interleukin-1beta; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Pravastatin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Treatment Outcome; Tumor Necrosis Factor-alpha

Topics: Animals; Brain Ischemia; Bromodeoxyuridine; Cell Count; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Male; Microtubule-Associated Proteins; Neurologic Examination; Neurons; Neuropeptides; Neuroprotective Agents; Phosphopyruvate Hydratase; Pravastatin; Rats; Rats, Wistar; Time Factors

Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GAP-43 Protein; Glyburide; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; KATP Channels; Ligation; Male; Myocardial Infarction; Myocardium; Neurofilament Proteins; Nicorandil; Norepinephrine; Pinacidil; Polymerase Chain Reaction; Potassium Channel Blockers; Pravastatin; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Tachycardia, Ventricular; Time Factors; Tyrosine 3-Monooxygenase; Ventricular Fibrillation; Ventricular Remodeling

Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Mitochondria, Heart; Myocardial Infarction; Nitric Oxide; Pravastatin; Protein Kinase C; Rabbits; Reactive Oxygen Species; Superoxides

Topics: Acetylcysteine; Adiponectin; Administration, Oral; Animals; Animals, Newborn; Antioxidants; Blood Glucose; Cells, Cultured; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids; Glucose; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Resistance; Ligation; Lipids; Male; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Pravastatin; Rats; Rats, Sprague-Dawley; Receptors, Adiponectin; Recombinant Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Time Factors; Tumor Necrosis Factor-alpha

Topics: Animals; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infarction, Middle Cerebral Artery; Male; Pravastatin; Rats; Rats, Wistar

Topics: Anabolic Agents; Animals; Animals, Newborn; Bone and Bones; Bone Resorption; Cells, Cultured; Disease Models, Animal; Female; Hydrophobic and Hydrophilic Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Inbred BALB C; Osteoclasts; Osteoporosis; Ovariectomy; Pravastatin; Protein Prenylation; Pyridines; Rabbits; rap1 GTP-Binding Proteins; Signal Transduction; Simvastatin; Water

Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Down-Regulation; Hepatolenticular Degeneration; Jejunum; Male; Mannitol; Pravastatin; Probenecid; Rats; Rats, Inbred LEC; Rats, Wistar; RNA, Messenger; Species Specificity; Sulfobromophthalein

Topics: Angiotensin II; Animals; Blood Pressure; Cholesterol; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart Failure, Diastolic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Pravastatin; rho-Associated Kinases; Ventricular Remodeling

Topics: Animals; Apolipoproteins B; Cells, Cultured; Cholesterol Esters; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Liver; Male; Pravastatin; Rabbits; Receptors, LDL

Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Anticholesteremic Agents; Binding, Competitive; Cells, Cultured; Cholesterol; Disease Models, Animal; Dogs; Drug Administration Schedule; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Iodine Radioisotopes; Isotope Labeling; Liver; Male; Pravastatin; Rabbits; Receptors, LDL; Species Specificity; Up-Regulation

Topics: Animals; Anticholesteremic Agents; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Captopril; Cardiovascular Diseases; Cholesterol; Coronary Vessels; Disease Models, Animal; Disease Progression; Dogs; Drug Therapy, Combination; Heart; Insulin; Insulin Resistance; Linear Models; Male; Multivariate Analysis; Myocardium; Obesity; Pravastatin; Triglycerides

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arteriosclerosis; Carotid Arteries; Chickens; Cholesterol; Disease Models, Animal; Herpesvirus 2, Gallid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Isoquinolines; Lymphocytes; Marek Disease; Pravastatin; Quinapril; Tetrahydroisoquinolines

Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Blood Glucose; Cholesterol, LDL; Chromans; Coronary Vessels; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Glucose Tolerance Test; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperinsulinism; Hyperlipoproteinemia Type II; Hypoglycemic Agents; Insulin Resistance; Male; Pravastatin; Rabbits; Thiazoles; Thiazolidinediones; Troglitazone; Xanthomatosis

Topics: 5'-Nucleotidase; Animals; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Pravastatin; Rabbits; Treatment Outcome; Triglycerides

Topics: Administration, Oral; Animals; Anticholesteremic Agents; Cardiomyopathies; Cricetinae; Disease Models, Animal; Female; Lovastatin; Male; Pravastatin; Sex Factors; Survival Analysis; Ubiquinone

Topics: Actins; Animals; Cholesterol; Disease Models, Animal; Fatty Acids, Monounsaturated; Fibrosis; Fluvastatin; Gene Expression; Glycation End Products, Advanced; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney; Membrane Proteins; Mice; Nephritis, Interstitial; Oxidative Stress; Pravastatin; RNA, Messenger; Triglycerides; Ureteral Obstruction

Topics: Allosteric Site; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Disease Models, Animal; Drug Design; Humans; Integrin alpha4beta1; Integrins; Intercellular Adhesion Molecule-1; Lovastatin; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Mice; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Naphthalenes; Peritonitis; Pravastatin; Protein Binding; Receptors, Lymphocyte Homing; T-Lymphocytes

Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Cardiomyopathies; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Pravastatin; Rats; Rats, Wistar; Thromboxane B2

Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Blood Pressure; Chemokine CCL2; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Lipids; Macrophages; Male; Monocytes; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Nitroarginine; Peptidyl-Dipeptidase A; Pravastatin; Proliferating Cell Nuclear Antigen; Pyridines; Rats; Rats, Inbred WKY; rhoA GTP-Binding Protein; RNA, Messenger; Systole; Transforming Growth Factor beta; Transforming Growth Factor beta1

Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Disease Models, Animal; Fatty Acids, Monounsaturated; Fluvastatin; Indoles; Lipids; Pravastatin; Rabbits

Topics: Animals; Anticholesteremic Agents; Cholesterol; Cricetinae; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mesocricetus; Pravastatin; Quinuclidines

Topics: Actins; Animals; Anticholesteremic Agents; Antioxidants; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Diet, Atherogenic; Disease Models, Animal; Elasticity; Hypercholesterolemia; Male; Membrane Transport Proteins; Muscle, Smooth, Vascular; Myosin Heavy Chains; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Pravastatin; Probucol; Protein Isoforms; Rabbits; Smooth Muscle Myosins; Superoxides

Topics: Animals; Bile; Bile Acids and Salts; Cholelithiasis; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Phospholipids; Pravastatin; Sciuridae

Topics: Animals; Anticholesteremic Agents; Apolipoproteins; Body Weight; Cholesterol; Coconut Oil; Diabetes Complications; Diabetes Mellitus; Diet, Atherogenic; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Male; Naphthalenes; Plant Oils; Pravastatin; Rabbits; Triglycerides

Topics: Animals; Cholelithiasis; Cholesterol; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Sciuridae

Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Cholesterol Esters; Cholestyramine Resin; Disease Models, Animal; Foam Cells; Heptanoic Acids; Hyperlipidemia, Familial Combined; Lipoproteins, LDL; Liver; Macrophages; Mice; Naphthalenes; Pravastatin; Probucol; Rabbits; Receptors, Cell Surface; Receptors, Lipoprotein