Page last updated: 2024-08-23

pravastatin and Cardiomegaly

pravastatin has been researched along with Cardiomegaly in 10 studies

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (10.00)	18.2507
2000's	4 (40.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Li, J; Liu, X; Wu, W; Zhao, M	1
Elnakish, MT; Hassanain, HH; Janssen, PM; Khan, M; Moldovan, L	1
Fukumoto, Y; Kudo, S; Liao, JK; Minami, T; Nochioka, K; Shiba, N; Shimokawa, H; Takai, Y; Tanaka, S; Williams, CL	1
Ikeda, S; Kikuchi, N; Kudo, S; Kurosawa, R; Minami, T; Miyata, S; Nogi, M; Omura, J; Satoh, K; Satoh, T; Shimokawa, H; Sunamura, S; Suzuki, K	1
Asakura, M; Asano, Y; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Liao, Y; Minamino, T; Takashima, S; Zhao, H	1
Alhaj, MA; Elnakish, MT; Hassanain, HH; Hassona, MD; Janssen, PM; Khan, M; Moldovan, L	1
Granberry, MC; Kennedy, RH; Liu, H; Melchert, RB	1
Ikeda, U; Kobayashi, E; Mano, H; Ogata, Y; Ookawara, S; Shimada, K; Takahashi, M; Takeuchi, K; Ueno, S	1
Arai, H; Matsuo, K; Miura, S; Nishikawa, H; Saku, K; Shimomura, H; Tsuchiya, Y; Zhang, B	1
Haneda, T; Kashiwagi, Y; Kawabe, J; Kikuchi, K; Nakamura, Y; Oi, S; Osaki, J	1

Trials

1 trial(s) available for pravastatin and Cardiomegaly

Article	Year
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation. Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:7 Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection	2013

Article

Year

Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.

Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:7

Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection

2013

Other Studies

9 other study(ies) available for pravastatin and Cardiomegaly

Article	Year
Involvement of TRPC1 in Nampt-induced cardiomyocyte hypertrophy through the activation of ER stress. Cellular and molecular biology (Noisy-le-Grand, France), 2017, Apr-29, Volume: 63, Issue:4 Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Endoplasmic Reticulum Stress; Gene Expression Regulation; Humans; Myocytes, Cardiac; Natriuretic Peptide, Brain; Nicotinamide Phosphoribosyltransferase; Pravastatin; Rats; RNA, Small Interfering; Transfection; TRPC Cation Channels	2017
Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles. Journal of cardiovascular pharmacology, 2013, Volume: 61, Issue:6 Topics: Animals; Cardiomegaly; Echocardiography; Electrocardiography; Heart; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Myocardial Contraction; Myocytes, Cardiac; Neuropeptides; Papillary Muscles; Pravastatin; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Thyroxine	2013
SmgGDS as a Crucial Mediator of the Inhibitory Effects of Statins on Cardiac Hypertrophy and Fibrosis: Novel Mechanism of the Pleiotropic Effects of Statins. Hypertension (Dallas, Tex. : 1979), 2016, Volume: 67, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Cardiomegaly; Cell Proliferation; Cells, Cultured; Chemokines; Cytoskeletal Proteins; Disease Models, Animal; Fibrosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Myocytes, Cardiac; Pravastatin; Random Allocation; Rats; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Role; Species Specificity	2016
Inhibition of cardiac remodeling by pravastatin is associated with amelioration of endoplasmic reticulum stress. Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:10 Topics: Animals; Apoptosis; Cardiomegaly; Endoplasmic Reticulum; Fibrosis; Heart Failure; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Molecular Chaperones; Myocardium; Myocytes, Cardiac; Pravastatin; Signal Transduction; Stress, Physiological; Tumor Necrosis Factor-alpha; Ventricular Pressure; Ventricular Remodeling	2008
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis. PloS one, 2012, Volume: 7, Issue:8 Topics: Animals; Apoptosis; Blotting, Western; Carbazoles; Cardiomegaly; Cardiomyopathies; Carvedilol; Echocardiography; Female; Fibrosis; Male; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Pravastatin; Propanolamines; rac GTP-Binding Proteins; Thyroxine; Vasodilator Agents	2012
Lovastatin inhibits phenylephrine-induced ERK activation and growth of cardiac. Cardiovascular toxicology, 2001, Volume: 1, Issue:3 Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Blotting, Western; Cardiomegaly; Cells, Cultured; Coloring Agents; Enzyme Activation; Heart; Lovastatin; Mitogen-Activated Protein Kinases; Myocardium; Phenylephrine; Phosphorylation; Pravastatin; Propidium; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles	2001
Fluvastatin induces apoptosis in rat neonatal cardiac myocytes: a possible mechanism of statin-attenuated cardiac hypertrophy. Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:6 Topics: Animals; Animals, Newborn; Apoptosis; Cardiomegaly; Cells, Cultured; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Indoles; Monomeric GTP-Binding Proteins; Myocytes, Cardiac; Pravastatin; Rats; Rats, Sprague-Dawley; Signal Transduction	2002
Statins induce the regression of left ventricular mass in patients with angina. Circulation journal : official journal of the Japanese Circulation Society, 2004, Volume: 68, Issue:2 Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Cardiomegaly; Case-Control Studies; Constriction, Pathologic; Drug Evaluation; Female; Heart Ventricles; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Middle Aged; Pravastatin; Retrospective Studies; Simvastatin	2004
Lovastatin prevents angiotensin II-induced cardiac hypertrophy in cultured neonatal rat heart cells. European journal of pharmacology, 1999, Jul-02, Volume: 376, Issue:1-2 Topics: Angiotensin II; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cell Division; Cell Membrane; Cells, Cultured; DNA; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Myocardium; Naphthalenes; Pravastatin; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; RNA; Simvastatin	1999