Page last updated: 2024-09-03

pramipexole and Amyotrophic Lateral Sclerosis

pramipexole has been researched along with Amyotrophic Lateral Sclerosis in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (21.43)	29.6817
2010's	10 (71.43)	24.3611
2020's	1 (7.14)	2.80

Authors

Authors	Studies
Desaphy, JF; Lentini, G; Majoral, JP; Mignani, S	1
Eijkemans, MJC; Ferguson, TA; Liu, D; Nikolakopoulos, S; van den Berg, LH; van Eijk, RPA	1
Gordon, PH	1
Archibald, D; Bozik, ME; Cudkowicz, ME; Dong, Y; Farwell, WR; Hardiman, O; Ingersoll, EW; Kerr, DA; Ludolph, A; Meyers, AL; Mitsumoto, H; Mora, JS; Shefner, JM; van den Berg, LH	1
He, P; Kerr, D; Stecher, S; Wei, D; Wu, C; Yang, L	1
Finkbeiner, S; Gill, A; Kidd, JD; LaDow, E; Levine, B; Moreno, A; Perrin, S; Thompson, K; Vieira, FG	1
Cudkowicz, M; Ferguson, T; Johns, DR; Leitner, ML; Liu, D; Schoenfeld, D; Shefner, JM	1
Ascherio, A; Cudkowicz, ME; Johns, DR; Leitner, M; Liu, D; O'Reilly, ÉJ; Paganoni, S; Schwarzschild, MA	1
Bozik, ME; Gribkoff, VK	1
Cheah, BC; Kiernan, MC	1
Amburgey, C; Archibald, D; Bozik, ME; Cudkowicz, M; Gribkoff, VK; Ingersoll, EW; Mather, JL; Miller, R; Mitsumoto, H; Moore, DH; Moritz, J; Schoenfeld, D; Shefner, J; Sullivan, M	1
Archibald, D; Berry, JD; Cudkowicz, ME; Dong, Y; Ingersoll, E; Kerr, DA; Rudnicki, SA	1
Bennett, JP; Gerber, RE; Pattee, GL; Post, GR	1
Bennett, JP; Burns, TM; Conaway, MA; Keller, KE; Lacomis, D; Larriviere, KS; Pattee, GL; Phillips, LH; Solenski, NJ; Wang, H; Ware, KA; Zivkovic, SA	1

Reviews

4 review(s) available for pramipexole and Amyotrophic Lateral Sclerosis

Article	Year
From Riluzole to Dexpramipexole via Substituted-Benzothiazole Derivatives for Amyotrophic Lateral Sclerosis Disease Treatment: Case Studies. Molecules (Basel, Switzerland), 2020, Jul-22, Volume: 25, Issue:15 Topics: Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Clinical Trials as Topic; Drug Approval; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Pramipexole; Riluzole; Small Molecule Libraries; Toluene; Treatment Outcome	2020
Increasing the efficiency of clinical trials in neurodegenerative disorders using group sequential trial designs. Journal of clinical epidemiology, 2018, Volume: 98 Topics: Amyotrophic Lateral Sclerosis; Central Nervous System Agents; Confidence Intervals; Early Termination of Clinical Trials; Equivalence Trials as Topic; Humans; Medical Futility; Neurodegenerative Diseases; Placebos; Pramipexole; Randomized Controlled Trials as Topic; Research Design; Time Factors	2018
KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the treatment of amyotrophic lateral sclerosis. CNS neuroscience & therapeutics, 2008,Fall, Volume: 14, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Dopamine Agonists; Humans; Mitochondria; Neuroprotective Agents; Pramipexole; Stereoisomerism	2008
Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs : the investigational drugs journal, 2010, Volume: 13, Issue:12 Topics: Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Dopamine Agonists; Drugs, Investigational; Humans; Isomerism; Pramipexole	2010

Trials

7 trial(s) available for pramipexole and Amyotrophic Lateral Sclerosis

Article	Year
Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial. The Lancet. Neurology, 2013, Volume: 12, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Antioxidants; Benzothiazoles; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Placebos; Pramipexole; Treatment Outcome; Young Adult	2013
Chiral liquid chromatography-tandem mass spectrometry assay to determine that dexpramipexole is not converted to pramipexole in vivo after administered in humans. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Nov-15, Volume: 971 Topics: Amyotrophic Lateral Sclerosis; Benzothiazoles; Chromatography, Liquid; Drug Stability; Humans; Placebos; Pramipexole; Quality Control; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry	2014
Quantitative strength testing in ALS clinical trials. Neurology, 2016, Aug-09, Volume: 87, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Benzothiazoles; Ceftriaxone; Female; Humans; Male; Muscle Strength Dynamometer; Outcome Assessment, Health Care; Pramipexole	2016
Serum urate at trial entry and ALS progression in EMPOWER. Amyotrophic lateral sclerosis & frontotemporal degeneration, 2017, Volume: 18, Issue:1-2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Antioxidants; Benzothiazoles; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Humans; International Cooperation; Male; Middle Aged; Pramipexole; Sex Factors; Survival Analysis; Uric Acid; Young Adult	2017
The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nature medicine, 2011, Nov-20, Volume: 17, Issue:12 Topics: Aged; Amyotrophic Lateral Sclerosis; Benzothiazoles; Double-Blind Method; Female; Humans; Male; Middle Aged; Mitochondria; Muscle Strength; Muscles; Pramipexole; Riluzole; Single-Blind Method	2011
Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics. Amyotrophic lateral sclerosis & frontotemporal degeneration, 2013, Volume: 14, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Benzothiazoles; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Pramipexole; Prevalence; Recovery of Function; Risk Factors; Survival Analysis; Survival Rate; Treatment Outcome; United States; Young Adult	2013
Reduction of oxidative stress in amyotrophic lateral sclerosis following pramipexole treatment. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2003, Volume: 4, Issue:2 Topics: Aged; Amyotrophic Lateral Sclerosis; Antioxidants; Benzothiazoles; Humans; Hydroxybenzoates; Middle Aged; Oxidative Stress; Patient Dropouts; Pramipexole; Thiazoles	2003

Other Studies

3 other study(ies) available for pramipexole and Amyotrophic Lateral Sclerosis

Article	Year
The murky path to drug discovery in ALS becomes clearer. The Lancet. Neurology, 2013, Volume: 12, Issue:11 Topics: Amyotrophic Lateral Sclerosis; Antioxidants; Benzothiazoles; Female; Humans; Male; Pramipexole	2013
Dexpramipexole is ineffective in two models of ALS related neurodegeneration. PloS one, 2014, Volume: 9, Issue:12 Topics: Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Benzothiazoles; Cells, Cultured; DNA-Binding Proteins; Humans; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pramipexole; Rats; Rats, Long-Evans; Superoxide Dismutase; Superoxide Dismutase-1	2014
R+ pramipexole as a mitochondrially focused neuroprotectant: initial early phase studies in ALS. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2008, Volume: 9, Issue:1 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Benzothiazoles; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Mitochondria; Neuroprotective Agents; Pramipexole; Time Factors	2008