Compounds > pralnacasan
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pralnacasan and Colitis

pralnacasan has been researched along with Colitis in 2 studies

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bauer, C; Dauer, M; Eigler, A; Endres, S; Landauer, N; Lehr, HA; Loher, F; Schmall, K; Schoenharting, M; Siegmund, B1
Bauer, C; Dauer, M; Eigler, A; Endres, S; Hallwachs, R; Lehr, HA; Loher, F; Mayer, C; Schönharting, M1

Other Studies

2 other study(ies) available for pralnacasan and Colitis

ArticleYear
The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:2

    Topics: Animals; Azepines; Caspase Inhibitors; Colitis; Colon; Dextran Sulfate; Drug Interactions; Female; Interferon-gamma; Interleukin-1; Interleukin-18; Isoquinolines; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Para-Aortic Bodies; Pyridazines; Spleen; T-Lymphocytes, Helper-Inducer

2004
The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:7

    Topics: Animals; Azepines; Caspase 1; Caspase Inhibitors; Chemokine CCL2; Chemokine CXCL1; Chemokine CXCL10; Chemokines, CXC; Colitis; Colon; Dextran Sulfate; Epithelium; Female; Interferon-gamma; Interleukin-18; Isoquinolines; Mice; Mice, Inbred C57BL; Pyridazines; RNA, Messenger; Th1 Cells; Tumor Necrosis Factor-alpha

2007